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Aliases for CPB1 Gene

Aliases for CPB1 Gene

  • Carboxypeptidase B1 (Tissue) 2 3
  • Pancreatic Carboxypeptidase B 2 3
  • Tissue Carboxypeptidase B 2 3
  • Pancreas-Specific Protein 3 4
  • Protaminase 2 3
  • EC 3.4.17.2 4 63
  • PASP 3 4
  • PCPB 3 4
  • CPB 3 4
  • Procarboxypeptidase B 3
  • EC 3.4.17 63

External Ids for CPB1 Gene

Previous GeneCards Identifiers for CPB1 Gene

  • GC03P145494
  • GC03P149430
  • GC03P149827
  • GC03P149866
  • GC03P150028
  • GC03P148508
  • GC03P145918

Summaries for CPB1 Gene

Entrez Gene Summary for CPB1 Gene

  • Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPB1 Gene

CPB1 (Carboxypeptidase B1 (Tissue)) is a Protein Coding gene. Diseases associated with CPB1 include acute pancreatitis and tricuspid valve insufficiency. Among its related pathways are Transport to the Golgi and subsequent modification and Pancreatic secretion. GO annotations related to this gene include metallocarboxypeptidase activity and carboxypeptidase activity. An important paralog of this gene is CPA3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPB1 Gene

Genomics for CPB1 Gene

Regulatory Elements for CPB1 Gene

Genomic Location for CPB1 Gene

Chromosome:
3
Start:
148,791,102 bp from pter
End:
148,860,192 bp from pter
Size:
69,091 bases
Orientation:
Plus strand

Genomic View for CPB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPB1 Gene

Proteins for CPB1 Gene

  • Protein details for CPB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15086-CBPB1_HUMAN
    Recommended name:
    Carboxypeptidase B
    Protein Accession:
    P15086
    Secondary Accessions:
    • O60834
    • Q53XJ0
    • Q96BQ8

    Protein attributes for CPB1 Gene

    Size:
    417 amino acids
    Molecular mass:
    47368 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CPB1 Gene

neXtProt entry for CPB1 Gene

Proteomics data for CPB1 Gene at MOPED

Selected DME Specific Peptides for CPB1 Gene

Post-translational modifications for CPB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPB1 Gene

Antibody Products

  • R&D Systems Antibodies for CPB1 (Carboxypeptidase B1/CPB1)

Domains & Families for CPB1 Gene

Gene Families for CPB1 Gene

Suggested Antigen Peptide Sequences for CPB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15086

UniProtKB/Swiss-Prot:

CBPB1_HUMAN :
  • Belongs to the peptidase M14 family.
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPB1: view

Function for CPB1 Gene

Molecular function for CPB1 Gene

GENATLAS Biochemistry:
carboxypeptidase B1 (tissue)
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential release of a C-terminal lysine or arginine amino acid

Enzyme Numbers (IUBMB) for CPB1 Gene

Gene Ontology (GO) - Molecular Function for CPB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity TAS 1370825
GO:0004181 metallocarboxypeptidase activity IBA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CPB1: view
genes like me logo Genes that share phenotypes with CPB1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPB1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CPB1 Gene

Localization for CPB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPB1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPB1 Gene COMPARTMENTS Subcellular localization image for CPB1 gene
Compartment Confidence
extracellular 5
endosome 2
lysosome 2
vacuole 2
cytoskeleton 1
cytosol 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CPB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CPB1: view

Pathways & Interactions for CPB1 Gene

genes like me logo Genes that share pathways with CPB1: view

Pathways by source for CPB1 Gene

Gene Ontology (GO) - Biological Process for CPB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IBA --
genes like me logo Genes that share ontologies with CPB1: view

No data available for SIGNOR curated interactions for CPB1 Gene

Drugs & Compounds for CPB1 Gene

(11) Drugs for CPB1 Gene - From: HMDB, DrugBank, and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404
(2S)-2-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-3-[(S)-HYDROXY(3-PHENYLPROPYL)PHOSPHORYL]PROPANOIC ACID Experimental Pharma Target 0
(2S)-2-[3-(AMINOMETHYL)PHENYL]-3-[(R)-[(1R)-1-{[(BENZYLOXY)CARBONYL]AMINO}-2-METHYLPROPYL](HYDROXY)PHOSPHORYL]PROPANOIC ACID Experimental Pharma Target 0
(2S)-2-[3-(AMINOMETHYL)PHENYL]-3-[(R)-HYDROXY{(1R)-2-METHYL-1-[(PHENYLSULFONYL)AMINO]PROPYL}PHOSPHORYL]PROPANOIC ACID Experimental Pharma Target 0
(2S)-2-[3-(AMINOMETHYL)PHENYL]-3-{(R)-HYDROXY[(1R)-2-METHYL-1-{[(3-PHENYLPROPYL)SULFONYL]AMINO}PROPYL]PHOSPHORYL}PROPANOIC ACID Experimental Pharma Target 0

(1) Additional Compounds for CPB1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PCBS
genes like me logo Genes that share compounds with CPB1: view

Transcripts for CPB1 Gene

Unigene Clusters for CPB1 Gene

Carboxypeptidase B1 (tissue):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPB1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPB1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b
SP1: - - - -
SP2: - - - - - - - - - -
SP3:
SP4: -
SP5: -
SP6:

Relevant External Links for CPB1 Gene

GeneLoc Exon Structure for
CPB1
ECgene alternative splicing isoforms for
CPB1

Expression for CPB1 Gene

mRNA expression in normal human tissues for CPB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPB1 Gene

This gene is overexpressed in Pancreas (x52.6).

Protein differential expression in normal tissues from HIPED for CPB1 Gene

This gene is overexpressed in Pancreatic juice (61.5) and Pancreas (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CPB1 Gene



SOURCE GeneReport for Unigene cluster for CPB1 Gene Hs.477891

mRNA Expression by UniProt/SwissProt for CPB1 Gene

P15086-CBPB1_HUMAN
Tissue specificity: Pancreas
genes like me logo Genes that share expression patterns with CPB1: view

Protein tissue co-expression partners for CPB1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CPB1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CPB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CPB1 35
  • 86.25 (n)
  • 82.49 (a)
CPB1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPB1 35
  • 87.66 (n)
  • 84.34 (a)
CPB1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpb1 35
  • 78.07 (n)
  • 74.46 (a)
Cpb1 16
Cpb1 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CPB1 35
  • 98.96 (n)
  • 98.32 (a)
CPB1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpb1 35
  • 79.2 (n)
  • 76.14 (a)
oppossum
(Monodelphis domestica)
Mammalia CPB1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
-- 36
  • 59 (a)
OneToMany
chicken
(Gallus gallus)
Aves CPB1 35
  • 69.06 (n)
  • 67.87 (a)
CPB1 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPB1 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494117 35
  • 58.82 (n)
  • 51.46 (a)
Str.5708 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.26001 35
zebrafish
(Danio rerio)
Actinopterygii cpb1 35
  • 69.44 (n)
  • 67.8 (a)
wufb60d07 35
cpb1 36
  • 58 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2214 35
fruit fly
(Drosophila melanogaster)
Insecta CG12374 37
  • 30 (a)
CG14820 37
  • 30 (a)
CG15769 37
  • 30 (a)
CG17633 37
  • 33 (a)
CG18415 37
  • 29 (a)
CG18417 37
  • 35 (a)
CG18585 37
  • 32 (a)
CG2915 37
  • 31 (a)
CG3097 37
  • 28 (a)
CG3108 37
  • 35 (a)
CG4017 37
  • 35 (a)
CG4408 37
  • 28 (a)
CG7025 37
  • 32 (a)
CG8539 37
  • 28 (a)
CG8560 37
  • 32 (a)
CG8562 37
  • 32 (a)
CG4017 35
  • 45.93 (n)
  • 37.02 (a)
CG12374 36
  • 26 (a)
ManyToMany
CG14820 36
  • 29 (a)
ManyToMany
CG17633 36
  • 30 (a)
ManyToMany
CG18417 36
  • 32 (a)
ManyToMany
CG18585 36
  • 31 (a)
ManyToMany
CG2915 36
  • 27 (a)
ManyToMany
CG32379 36
  • 30 (a)
ManyToMany
CG4017 36
  • 33 (a)
ManyToMany
CG4408 36
  • 25 (a)
ManyToMany
CG7025 36
  • 32 (a)
ManyToMany
CG8539 36
  • 25 (a)
ManyToMany
CG8560 36
  • 32 (a)
ManyToMany
CG8562 36
  • 32 (a)
ManyToMany
CG8563 36
  • 27 (a)
ManyToMany
CG8564 36
  • 18 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea R11A5.7 37
  • 32 (a)
W01A8.6 37
  • 31 (a)
Y18H1A.9 37
  • 33 (a)
Y47G6A.19 37
  • 31 (a)
Y59C2A.1 37
  • 29 (a)
ZC434.9 37
  • 31 (a)
F02D8.4 36
  • 28 (a)
ManyToMany
suro-1 36
  • 20 (a)
ManyToMany
T06A4.1 36
  • 24 (a)
ManyToMany
T06A4.3 36
  • 25 (a)
ManyToMany
W01A8.6 36
  • 27 (a)
ManyToMany
Y18H1A.9 36
  • 29 (a)
ManyToMany
Y47G6A.19 36
  • 28 (a)
ManyToMany
ZC434.9 36
  • 19 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM14 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
CSA.11311 36
  • 35 (a)
ManyToMany
CSA.4005 36
  • 18 (a)
ManyToMany
Species with no ortholog for CPB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPB1 Gene

ENSEMBL:
Gene Tree for CPB1 (if available)
TreeFam:
Gene Tree for CPB1 (if available)

Paralogs for CPB1 Gene

Paralogs for CPB1 Gene

(9) SIMAP similar genes for CPB1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CPB1: view

Variants for CPB1 Gene

Sequence variations from dbSNP and Humsavar for CPB1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs968894 -- 148,852,493(+) AATAA(A/C)TATAA intron-variant
rs1059502 - 148,844,523(+) TTCTC(A/G)ACAAG missense, reference
rs1318579 -- 148,835,773(+) TAGCC(G/T)ATATA intron-variant
rs1352897 -- 148,825,624(+) ATATT(A/G)ACTAT intron-variant
rs1356259 -- 148,857,654(+) CACAG(C/T)AAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPB1 Gene

Variant ID Type Subtype PubMed ID
nsv829751 CNV Loss 17160897
esv2507087 CNV Deletion 19546169
esv1937920 CNV Deletion 18987734
esv5048 CNV Deletion 18987735
esv2726034 CNV Deletion 23290073
dgv127n6 CNV Loss 16902084
esv998869 CNV Deletion 20482838
esv6949 CNV Loss 19470904
esv1368988 CNV Deletion 17803354

Variation tolerance for CPB1 Gene

Residual Variation Intolerance Score: 61.38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.48; 55.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPB1 Gene

HapMap Linkage Disequilibrium report
CPB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPB1 Gene

Disorders for CPB1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CPB1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
acute pancreatitis
  • acute pancreatitis [ambiguous]
tricuspid valve insufficiency
  • tricuspid valve regurgitation
trachea leiomyoma
  • neoplasm of trachea
tricuspid valve disease
  • rheumatic tricuspid valve disease
pancreatitis
- elite association
Search CPB1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CPB1

Genetic Association Database (GAD)
CPB1
Human Genome Epidemiology (HuGE) Navigator
CPB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPB1
genes like me logo Genes that share disorders with CPB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPB1 Gene

Publications for CPB1 Gene

  1. Poly(adenylic acid) complementary DNA real-time polymerase chain reaction in pancreatic ductal juice in patients undergoing pancreaticoduodenectomy. (PMID: 19940796) Oliveira-Cunha M. … Siriwardena A.K. (Pancreas 2010) 23 67
  2. Attacking the source: anti-PDX-1 responses in type 1 diabetes. (PMID: 20038945) Luzardo Y. … Mathews C.E. (Lab. Invest. 2010) 23 67
  3. A new type of five-membered heterocyclic inhibitors of basic metallocarboxypeptidases. (PMID: 19386397) FernA!ndez D. … Vendrell J. (Eur J Med Chem 2009) 23 67
  4. [Thrombin activatable fibrinolysis inhibitor (TAFI) and its importance in the regulation of fibrinolysis]. (PMID: 15015228) Stasko J. … Kubisz P. (Vnitr Lek 2004) 23 67
  5. The p11 subunit of annexin II heterotetramer is regulated by basic carboxypeptidase. (PMID: 11939791) Fogg D.K. … Waisman D.M. (Biochemistry 2002) 23 67

Products for CPB1 Gene

Sources for CPB1 Gene

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