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CPB1 Gene

protein-coding   GIFtS: 67
GCID: GC03P148508

Carboxypeptidase B1 (Tissue)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carboxypeptidase B1 (Tissue)1 2     PASP2 3
Pancreatic Carboxypeptidase B1 2     PCPB2 3
protaminase1 2     EC 3.4.17.23 8
Tissue Carboxypeptidase B1 2     Carboxypeptidase B2
Pancreas-Specific Protein2 3     Procarboxypeptidase B2
CPB2 3     EC 3.4.178

External Ids:    HGNC: 22991   Entrez Gene: 13602   Ensembl: ENSG000001530027   OMIM: 1148525   UniProtKB: P150863   

Export aliases for CPB1 gene to outside databases

Previous GC identifers: GC03P145494 GC03P149430 GC03P149827 GC03P149866 GC03P150028 GC03P145918


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CPB1 Gene:
Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2
forms differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein
and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated
in pancreatic carcinoma. (provided by RefSeq, Jul 2008)

GeneCards Summary for CPB1 Gene:
CPB1 (carboxypeptidase B1 (tissue)) is a protein-coding gene. Diseases associated with CPB1 include trachea leiomyoma, and tricuspid valve insufficiency. GO annotations related to this gene include metallocarboxypeptidase activity and carboxypeptidase activity. An important paralog of this gene is CPO.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CPB1 gene promoter:
         HOXA9   HOXA9B   NCX/Ncx   Lmo2   C/EBPalpha   POU2F1   HNF-1   POU2F1a   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPB1 promoter sequence
   Search Chromatin IP Primers for CPB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q24   Ensembl cytogenetic band:  3q24   HGNC cytogenetic band: 3q24

CPB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPB1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P148508:  view genomic region     (about GC identifiers)

Start:
148,508,889 bp from pter      End:
148,577,974 bp from pter
Size:
69,086 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CBPB1_HUMAN, P15086 (See protein sequence)
Recommended Name: Carboxypeptidase B precursor  
Size: 417 amino acids; 47368 Da
Cofactor: Binds 1 zinc ion per subunit
2 PDB 3D structures from and Proteopedia for CPB1:
1KWM (3D)        1ZLI (3D)    
Secondary accessions: O60834 Q53XJ0 Q96BQ8

Explore the universe of human proteins at neXtProt for CPB1: NX_P15086

Explore proteomics data for CPB1 at MOPED

Selected DME Specific Peptides for CPB1 (P15086) (see all 7)
 FELRDTG  WETIEAW  YTYGPGA  HAREWIS 


See CPB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001862.2  
ENSEMBL proteins: 
 ENSP00000417222   ENSP00000419114   ENSP00000417117   ENSP00000419427   ENSP00000282957  
Reactome Protein details: P15086

CPB1 Human Recombinant Protein Products:

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CPB1 Antibody Products:

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Cloud-Clone Corp. CLIAs for CPB1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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IUPHAR Guide to PHARMACOLOGY protein family classification: Carboxypeptidase B1 (tissue)
Metallocarboxypeptidases

3 InterPro protein domains:
 IPR003146 Prot_inh_M14A
 IPR000834 Peptidase_M14
 IPR009020 Prot_inh_propept

Graphical View of Domain Structure for InterPro Entry P15086

ProtoNet protein and cluster: P15086

2 Blocks protein domains:
IPB000834 Zinc carboxypeptidase A metalloprotease (M14)
IPB003146 Carboxypeptidase activation peptide


UniProtKB/Swiss-Prot: CBPB1_HUMAN, P15086
Similarity: Belongs to the peptidase M14 family


CPB1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CBPB1_HUMAN, P15086
Catalytic activity: Preferential release of a C-terminal lysine or arginine amino acid

     Genatlas biochemistry entry for CPB1:
carboxypeptidase B1 (tissue)

     Enzyme Numbers (IUBMB): EC 3.4.17.21 2 EC 3.4.172

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004180carboxypeptidase activity TAS1370825
GO:0004181metallocarboxypeptidase activity IEA--
GO:0008270zinc ion binding IEA--
     
CPB1 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for CPB1:
 Decreased number of cells in m 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CPB1
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   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPB1

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPB1

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPB1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CBPB1_HUMAN, P15086: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
endoplasmic reticulum2
cytosol1
endosome1
lysosome1
plasma membrane1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

CPB1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CPB1 About    
See pathways by source

SuperPathContained pathways About
1Peptide hormone metabolism
Peptide hormone metabolism0.30
Metabolism of Angiotensinogen to Angiotensins0.00
2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins0.30
3Protein digestion and absorption
Protein digestion and absorption
4Pancreatic secretion
Pancreatic secretion

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



1 Reactome Pathway for CPB1
    Metabolism of Angiotensinogen to Angiotensins


2 Kegg Pathways  (Kegg details for CPB1):
    Pancreatic secretion
Protein digestion and absorption


CPB1 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CPB1
Interactions:

    GeneGlobe Interaction Network for CPB1

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

Selected Interacting proteins for CPB1 (P150863 ENSP000002829574) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
InteractantInteraction Details
GeneCardExternal ID(s)
YWHAGP619813I2D: score=2 
KIAA1279Q96EK53I2D: score=1 
NCLENSP000003181954STRING: ENSP00000318195
CELA2AENSP000003526394STRING: ENSP00000352639
CELA2BENSP000003650754STRING: ENSP00000365075
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006508proteolysis ----

CPB1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CPB1 (CBPB1)

1 HMDB Compound for CPB1    About this table
CompoundSynonyms CAS #PubMed Ids
ZincZinc (see all 2)7440-66-6--

8 DrugBank Compounds for CPB1    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
(2S)-2-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-3-[(S)-HYDROXY(3-PHENYLPROPYL)PHOSPHORYL]PROPANOIC ACID-- --target--10592235
(2S)-2-[3-(AMINOMETHYL)PHENYL]-3-[(R)-HYDROXY{(1R)-2-METHYL-1-[(PHENYLSULFONYL)AMINO]PROPYL}PHOSPHORYL]PROPANOIC ACID-- --target--10592235
(2S)-2-[3-(AMINOMETHYL)PHENYL]-3-[(R)-[(1R)-1-{[(BENZYLOXY)CARBONYL]AMINO}-2-METHYLPROPYL](HYDROXY)PHOSPHORYL]PROPANOIC ACID-- --target--10592235
(2S)-2-[3-(AMINOMETHYL)PHENYL]-3-{(R)-HYDROXY[(1R)-2-METHYL-1-{[(3-PHENYLPROPYL)SULFONYL]AMINO}PROPYL]PHOSPHORYL}PROPANOIC ACID-- --target--10592235
(2S)-2-[3-(AMINOMETHYL)PHENYL]-3-{(S)-HYDROXY[(1R)-2-METHYL-1-{[(2-PHENYLETHYL)SULFONYL]AMINO}PROPYL]PHOSPHORYL}PROPANOIC ACID-- --target--10592235
(5R,6S,8S)-8-[3-(AMINOMETHYL)PHENYL]-6-HYDROXY-5-ISOPROPYL-3-OXO-1-PHENYL-2,7-DIOXA-4-AZA-6-PHOSPHANONAN-9-OIC ACID 6-OXIDE-- --target--10592235
2-(3-GUANIDINOPHENYL)-3-MERCAPTOPROPANOIC ACID-- --target--10592235
Citric Acid-- 77-92-9target----

3 Novoseek inferred chemical compound relationships for CPB1 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
pcbs 59.3 31 7727441 (4), 9261609 (4), 1370825 (3), 8322019 (2) (see all 5)
lysine 51.1 6 11127872 (2), 1776140 (1), 7727441 (1), 11027681 (1)
arginine 9.44 3 7727441 (1), 8428004 (1)



CPB1 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CPB1 gene: 
NM_001871.2  

Unigene Cluster for CPB1:

Carboxypeptidase B1 (tissue)
Hs.477891  [show with all ESTs]
Unigene Representative Sequence: CR749369
10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000491148(uc003ewl.3) ENST00000494888 ENST00000462345 ENST00000468341
ENST00000465718 ENST00000484877 ENST00000473621 ENST00000498639 ENST00000476847
ENST00000282957
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  QuantiFast Probe-based Assays in human, mouse, rat CPB1

Additional mRNA sequence: 

AJ224866.1 AK313940.1 BC015338.1 BT009910.1 CR749369.1 M81057.1 

Selected DOTS entries (see all 25):

DT.86858510  DT.100033489  DT.120929362  DT.100793616  DT.102833416  DT.91793463  DT.100793609  DT.121641595 
DT.95248364  DT.100793618  DT.100033483  DT.99938959  DT.100793619  DT.120929274  DT.120929288  DT.120929299 
DT.120929309  DT.120929328  DT.120929345  DT.120929348  DT.120929370  DT.120929371  DT.120929372  DT.95248361 

Selected AceView cDNA sequences (see all 474):

AA385943 BQ786925 BX496340 BI711373 BQ271384 BU785404 CA775919 AW583613 
BU786536 CA778131 BM505358 CA950237 CA844279 BQ786975 AA366318 BU072780 
CA941479 CA775860 BI467265 CA848196 CA867103 BQ269608 CA865622 BU784799 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for CPB1 (see all 6)    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b
SP1:              -                 -                                                           -     -                           
SP2:              -                 -           -     -     -     -     -     -                 -     -                           
SP3:                                                                                                                              
SP4:                                -                                                                                             
SP5:                                                                                                  -                           


ECgene alternative splicing isoforms for CPB1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CPB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCAGAGAGTG
CPB1 Expression
About this image

CPB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CPB1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.477891

UniProtKB/Swiss-Prot: CBPB1_HUMAN, P15086
Tissue specificity: Pancreas

    Custom PCR Arrays for CPB1
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QuantiFast Probe-based Assays in human, mouse, rat CPB1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPB1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for CPB1 gene from Selected species (see all 17)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cpb11 , 5 carboxypeptidase B1 (tissue)1, 5 78.07(n)1
74.46(a)1
  3 (6.29 cM)5
767031  NM_029706.11  NP_083982.11 
 202482645 
chicken
(Gallus gallus)
Aves CPB11 carboxypeptidase B1 (tissue) 69.06(n)
67.87(a)
  424888  NM_001277445.1  NP_001264374.1 
lizard
(Anolis carolinensis)
Reptilia CPB16
carboxypeptidase B1 (tissue)
70(a)
1 ↔ 1
3(19235202-19261456)
African clawed frog
(Xenopus laevis)
Amphibia Xl.260012 Xenopus laevis transcribed sequence with weak similarity more 74.57(n)    CF284662.1 
zebrafish
(Danio rerio)
Actinopterygii wufb60d072 wufb60d07 75.19(n)   322412  CA470865.1 
fruit fly
(Drosophila melanogaster)
Insecta CG184173
CG40171
CG40171 35(a)
(best of 16)3
45.93(n)1
37.02(a)1
  65F113
342961  NM_135465.41  NP_609309.11 
worm
(Caenorhabditis elegans)
Secernentea Y18H1A.93   -- 33(a)
(best of 6)
  I(748486-756927)   --
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM146
Putative metalloprotease with similarity to the zi...
27(a)
1 → many
VIII(368502-369794) YHR132C


ENSEMBL Gene Tree for CPB1 (if available)
TreeFam Gene Tree for CPB1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CPB1 gene
CPO2  CPA22  CPA12  CPA62  CPA32  CPA52  CPB22  CPA42  
9 SIMAP similar genes for CPB1 using alignment to 4 protein entries:     CBPB1_HUMAN (see all proteins):
DKFZp779K1333    CPO    CPA1    CPA3    CPA6    CPB2
CPA4    CPA2    CPA5

CPB1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CPB1 (see all 779)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1440462161,2
--148543643(+) ACATTG/TCTAGA 1 -- us2k10--------
rs2008408891,2
C--148543837(+) ATTTT-/AAAAAT 1 -- us2k10--------
rs1995150321,2
--148543839(+) TTTAA-/AAATG 
        
AATGA
1 -- us2k10--------
rs1412472651,2
C--148543841(+) TAAAA-/ATGAAT
        
GATTC
1 -- us2k10--------
rs2005429831,2
C--148543843(+) AAAAT-/GAATG 
        
ATTCA
1 -- us2k10--------
rs1913460411,2
--148543864(+) ACACTA/GAAGAC 1 -- us2k10--------
rs606844571,2
C,F--148544021(+) TATCAA/GAATTA 1 -- us2k13Minor allele frequency- G:0.12WA NA 240
rs117106331,2
C,F,H--148544051(+) acataA/Ccatta 1 -- us2k111Minor allele frequency- C:0.24NS EA NA CSA WA 760
rs787772171,2
F--148544079(+) GCCACA/TTACTG 1 -- us2k11Minor allele frequency- T:0.04WA 118
rs766865061,2
C,F--148544107(+) ATATAT/GTTCTA 1 -- us2k11Minor allele frequency- G:0.05WA 118

HapMap Linkage Disequilibrium report for CPB1 (148508889 - 148577974 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for CPB1:    About this table    
Variant IDTypeSubtypePubMed ID
esv2507087CNV Deletion19546169
esv1937920CNV Deletion18987734
esv1368988CNV Deletion17803354
esv2726034CNV Deletion23290073
esv998869CNV Deletion20482838
esv5048CNV Deletion18987735
dgv127n6CNV Loss16902084
nsv829751CNV Loss17160897
esv6949CNV Loss19470904

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 114852    OMIM disorders: --

12 diseases for CPB1:    
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trachea leiomyoma    tricuspid valve insufficiency    pancreatitis    acute pancreatitis
leiomyoma    diabetes mellitus    pancreatic cancer    hypertension
type 1 diabetes    hepatitis b    hepatitis    endotheliitis

4 diseases from the University of Copenhagen DISEASES database for CPB1:
Tricuspid valve insufficiency     Pulmonary hypertension     Pancreatitis     Trachea leiomyoma

CPB1 for disorders           About GeneDecksing

5 Novoseek inferred disease relationships for CPB1 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
pancreatitis alcoholic 66.6 1 7510410 (1)
acute pancreatitis 64.8 15 1688389 (3), 8322019 (3), 7510410 (2), 9524066 (1) (see all 6)
pancreatitis 50.6 9 1688389 (4), 7624299 (3), 9261609 (2)
pancreatic cancer 44.1 2 1688389 (1), 9261609 (1)
diabetes mellitus insulin-dependent 24.7 1 1584208 (1)

Genetic Association Database (GAD): CPB1
Human Genome Epidemiology (HuGE) Navigator: CPB1 (1 document)

Export disorders for CPB1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CPB1 gene, integrated from 10 sources (see all 38):
(articles sorted by number of sources associating them with CPB1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Isolation of a cDNA encoding a human serum marker for acute pancreatitis. Identification of pancreas-specific protein as pancreatic procarboxypeptidase B. (PubMed id 1370825)1, 2, 9 Yamamoto K.K....French C.K. (J. Biol. Chem. 1992)
  2. Comparative analysis of the sequences and three-dimensional models of human procarboxypeptidases A1, A2 and B. (PubMed id 9524066)1, 2, 9 Aloy P....Aviles F.X. (Biol. Chem. 1998)
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Human procarboxypeptidase B: three-dimensional structure and implications for thrombin-activatable fibrinolysis inhibitor (TAFI). (PubMed id 12162965)1, 2 Barbosa-Pereira P.J.... Vendrell J. (J. Mol. Biol. 2002)
  6. Purification and properties of five different forms of human procarboxypeptidases. (PubMed id 2920728)1, 2 Pascual R.... Aviles F.X. (Eur. J. Biochem. 1989)
  7. Isoforms of procarboxypeptidase B, (pancreas-specific protein, PASP) in human serum, pancreatic tissue and juice. (PubMed id 8322019)1, 9 Fernstad R....Pousette A. (Scand. J. Clin. Lab. Invest. Suppl. 1993)
  8. The NMR structure and dynamics of the two-domain tick carboxypeptidase inhibitor reveal flexibility in its free form and stiffness upon binding to human carboxypeptidase B. (PubMed id 18558717)1 Pantoja-Uceda D....Blanco F.J. (Biochemistry 2008)
  9. TAFI and pancreatic carboxypeptidase B modulate in vitro capillary tube formation by human microvascular endothelial cells. (PubMed id 17673703)1 GuimarALes A.H....Rijken D.C. (Arterioscler. Thromb. Vasc. Biol. 2007)
  10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1360 HGNC: 2299 AceView: CPB1 Ensembl:ENSG00000153002 euGenes: HUgn1360
ECgene: CPB1 Kegg: 1360 H-InvDB: CPB1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CPB1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CPB1 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CPB1 gene:
Search GeneIP for patents involving CPB1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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