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Aliases for CPB1 Gene

Aliases for CPB1 Gene

  • Carboxypeptidase B1 2 3 5
  • Pancreatic Carboxypeptidase B 2 3
  • Carboxypeptidase B1 (Tissue) 2 3
  • Tissue Carboxypeptidase B 2 3
  • Pancreas-Specific Protein 3 4
  • Protaminase 2 3
  • EC 4 61
  • PASP 3 4
  • PCPB 3 4
  • CPB 3 4
  • Procarboxypeptidase B 3
  • Carboxypeptidase B 3
  • EC 3.4.17 61

External Ids for CPB1 Gene

Previous GeneCards Identifiers for CPB1 Gene

  • GC03P145494
  • GC03P149430
  • GC03P149827
  • GC03P149866
  • GC03P150028
  • GC03P148508
  • GC03P145918

Summaries for CPB1 Gene

Entrez Gene Summary for CPB1 Gene

  • Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPB1 Gene

CPB1 (Carboxypeptidase B1) is a Protein Coding gene. Diseases associated with CPB1 include Acute Pancreatitis and Pancreatitis. Among its related pathways are Protein digestion and absorption and Metabolism of proteins. GO annotations related to this gene include metallocarboxypeptidase activity and carboxypeptidase activity. An important paralog of this gene is CPA3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPB1 Gene

Genomics for CPB1 Gene

Regulatory Elements for CPB1 Gene

Enhancers for CPB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F148790 0.8 FANTOM5 ENCODE 0.8 +0.4 421 2.9 SMARCA4 POLR2A CPA3 CPB1 HMGB1P30
GH03F148789 1.1 Ensembl 0.8 -1.8 -1802 0.2 OSR2 CTBP1 SMARCA4 FOXP2 TRIM28 CPB1 AGTR1
GH03F148757 0.5 Ensembl 0.3 -33.5 -33502 1.2 MAX TRIM28 CPB1 AGTR1
GH03F148736 1.1 Ensembl ENCODE 0.2 -54.0 -53958 0.9 SMARCC1 NFIA CEBPB CEBPG EP300 NR2F2 YY1 ATF3 CEBPA STAT3 AGTR1 CPB1
GH03F148723 0.8 Ensembl ENCODE 0.2 -67.3 -67273 1.0 HLF SIN3A CEBPB CEBPG RARA NFIL3 JUND CEBPA SMAD4 FOS RPL38P1 AGTR1 CPB1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CPB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CPB1 Gene

148,791,102 bp from pter
148,860,192 bp from pter
69,091 bases
Plus strand

Genomic View for CPB1 Gene

Genes around CPB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPB1 Gene

Proteins for CPB1 Gene

  • Protein details for CPB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carboxypeptidase B
    Protein Accession:
    Secondary Accessions:
    • O60834
    • Q53XJ0
    • Q96BQ8

    Protein attributes for CPB1 Gene

    417 amino acids
    Molecular mass:
    47368 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CPB1 Gene

neXtProt entry for CPB1 Gene

Selected DME Specific Peptides for CPB1 Gene


Post-translational modifications for CPB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPB1 Gene

Antibody Products

  • R&D Systems Antibodies for CPB1 (Carboxypeptidase B1/CPB1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for CPB1

Domains & Families for CPB1 Gene

Gene Families for CPB1 Gene

Suggested Antigen Peptide Sequences for CPB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M14 family.
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPB1: view

Function for CPB1 Gene

Molecular function for CPB1 Gene

GENATLAS Biochemistry:
carboxypeptidase B1 (tissue)
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential release of a C-terminal lysine or arginine amino acid.

Enzyme Numbers (IUBMB) for CPB1 Gene

Gene Ontology (GO) - Molecular Function for CPB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity TAS 1370825
GO:0004181 metallocarboxypeptidase activity IEA,IBA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CPB1: view
genes like me logo Genes that share phenotypes with CPB1: view

Animal Models for CPB1 Gene

MGI Knock Outs for CPB1:
  • Cpb1 tm1.1(KOMP)Vlcg

Animal Model Products

  • Taconic Biosciences Mouse Models for CPB1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CPB1 Gene

Localization for CPB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPB1 Gene


Subcellular locations from

Jensen Localization Image for CPB1 Gene COMPARTMENTS Subcellular localization image for CPB1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
endosome 2
lysosome 2
vacuole 2
cytoskeleton 1
cytosol 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CPB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CPB1: view

Pathways & Interactions for CPB1 Gene

genes like me logo Genes that share pathways with CPB1: view

Pathways by source for CPB1 Gene

Interacting Proteins for CPB1 Gene

Gene Ontology (GO) - Biological Process for CPB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with CPB1: view

No data available for SIGNOR curated interactions for CPB1 Gene

Drugs & Compounds for CPB1 Gene

(11) Drugs for CPB1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 2231

(1) Additional Compounds for CPB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CPB1: view

Transcripts for CPB1 Gene

Unigene Clusters for CPB1 Gene

Carboxypeptidase B1 (tissue):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPB1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b
SP1: - - - -
SP2: - - - - - - - - - -
SP4: -
SP5: -

Relevant External Links for CPB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CPB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPB1 Gene

This gene is overexpressed in Pancreas (x52.6).

Protein differential expression in normal tissues from HIPED for CPB1 Gene

This gene is overexpressed in Pancreatic juice (61.5) and Pancreas (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CPB1 Gene

Protein tissue co-expression partners for CPB1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CPB1 Gene:


SOURCE GeneReport for Unigene cluster for CPB1 Gene:


mRNA Expression by UniProt/SwissProt for CPB1 Gene:

Tissue specificity: Pancreas.
genes like me logo Genes that share expression patterns with CPB1: view

Primer Products

Orthologs for CPB1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CPB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CPB1 34 35
  • 98.96 (n)
(Canis familiaris)
Mammalia CPB1 34 35
  • 87.66 (n)
(Bos Taurus)
Mammalia CPB1 34 35
  • 86.25 (n)
(Rattus norvegicus)
Mammalia Cpb1 34
  • 79.2 (n)
(Mus musculus)
Mammalia Cpb1 34 16 35
  • 78.07 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 78 (a)
-- 35
  • 73 (a)
-- 35
  • 73 (a)
-- 35
  • 59 (a)
(Monodelphis domestica)
Mammalia CPB1 35
  • 76 (a)
(Gallus gallus)
Aves CPB1 34 35
  • 69.06 (n)
(Anolis carolinensis)
Reptilia CPB1 35
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494117 34
  • 58.82 (n)
Str.5708 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.26001 34
(Danio rerio)
Actinopterygii cpb1 34 35
  • 69.44 (n)
wufb60d07 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2214 34
fruit fly
(Drosophila melanogaster)
Insecta CG4017 36 34 35
  • 45.93 (n)
CG18417 36 35
  • 35 (a)
CG3108 36
  • 35 (a)
CG17633 36 35
  • 33 (a)
CG18585 36 35
  • 32 (a)
CG7025 36 35
  • 32 (a)
CG8560 36 35
  • 32 (a)
CG8562 36 35
  • 32 (a)
CG2915 36 35
  • 31 (a)
CG12374 36 35
  • 30 (a)
CG14820 36 35
  • 30 (a)
CG15769 36
  • 30 (a)
CG32379 35
  • 30 (a)
CG18415 36
  • 29 (a)
CG3097 36
  • 28 (a)
CG4408 36 35
  • 28 (a)
CG8539 36 35
  • 28 (a)
CG8563 35
  • 27 (a)
CG8564 35
  • 18 (a)
(Caenorhabditis elegans)
Secernentea Y18H1A.9 36 35
  • 33 (a)
R11A5.7 36
  • 32 (a)
W01A8.6 36 35
  • 31 (a)
Y47G6A.19 36 35
  • 31 (a)
ZC434.9 36 35
  • 31 (a)
Y59C2A.1 36
  • 29 (a)
F02D8.4 35
  • 28 (a)
T06A4.3 35
  • 25 (a)
T06A4.1 35
  • 24 (a)
suro-1 35
  • 20 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM14 35
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
-- 35
  • 35 (a)
CSA.11311 35
  • 35 (a)
CSA.4005 35
  • 18 (a)
Species where no ortholog for CPB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPB1 Gene

Gene Tree for CPB1 (if available)
Gene Tree for CPB1 (if available)

Paralogs for CPB1 Gene

Paralogs for CPB1 Gene

(9) SIMAP similar genes for CPB1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CPB1: view

Variants for CPB1 Gene

Sequence variations from dbSNP and Humsavar for CPB1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1059502 -- 148,844,523(+) TTCTC(A/G)ACAAG reference, missense
rs10605555 -- 148,846,754(+) ATATA(-/TA)CATAT intron-variant
rs10605556 -- 148,846,768(+) ATATA(-/TA)TACAC intron-variant
rs10935727 -- 148,827,913(+) CTTTA(A/G)GGAGC intron-variant
rs111460292 -- 148,835,050(+) GTCTA(A/C/G)AGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPB1 Gene

Variant ID Type Subtype PubMed ID
dgv127n6 CNV deletion 16902084
dgv2618n106 CNV deletion 24896259
esv1368988 CNV deletion 17803354
esv1937920 CNV deletion 18987734
esv2507087 CNV deletion 19546169
esv2726034 CNV deletion 23290073
esv2833236 CNV deletion 24192839
esv3562699 CNV deletion 23714750
esv3598134 CNV loss 21293372
esv5048 CNV loss 18987735
esv6949 CNV loss 19470904
esv998869 CNV deletion 20482838
nsv1074632 CNV deletion 25765185
nsv1147810 CNV deletion 26484159
nsv829751 CNV loss 17160897
nsv955536 CNV deletion 24416366

Variation tolerance for CPB1 Gene

Residual Variation Intolerance Score: 61.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.48; 55.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPB1 Gene

Disorders for CPB1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CPB1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acute pancreatitis
  • acute necrotizing pancreatitis
trachea leiomyoma
  • tracheal neoplasm
tricuspid valve disease
  • disease of tricuspid valve
- elite association - COSMIC cancer census association via MalaCards
Search CPB1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CPB1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CPB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPB1 Gene

Publications for CPB1 Gene

  1. Comparative analysis of the sequences and three-dimensional models of human procarboxypeptidases A1, A2 and B. (PMID: 9524066) Aloy P. … Aviles F.X. (Biol. Chem. 1998) 3 4 22 64
  2. Isolation of a cDNA encoding a human serum marker for acute pancreatitis. Identification of pancreas-specific protein as pancreatic procarboxypeptidase B. (PMID: 1370825) Yamamoto K.K. … French C.K. (J. Biol. Chem. 1992) 3 4 22 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Human procarboxypeptidase B: three-dimensional structure and implications for thrombin-activatable fibrinolysis inhibitor (TAFI). (PMID: 12162965) Barbosa-Pereira P.J. … Vendrell J. (J. Mol. Biol. 2002) 3 4 64

Products for CPB1 Gene

Sources for CPB1 Gene

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