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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPB1 Gene

protein-coding   GIFtS: 67
GCID: GC03P148508

Carboxypeptidase B1 (Tissue)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carboxypeptidase B1 (Tissue)1 2     PASP2 3
Pancreatic Carboxypeptidase B1 2     PCPB2 3
protaminase1 2     EC 3.4.17.23 8
Tissue Carboxypeptidase B1 2     Carboxypeptidase B2
Pancreas-Specific Protein2 3     Procarboxypeptidase B2
CPB2 3     EC 3.4.178

External Ids:    HGNC: 22991   Entrez Gene: 13602   Ensembl: ENSG000001530027   OMIM: 1148525   UniProtKB: P150863   

Export aliases for CPB1 gene to outside databases

Previous GC identifers: GC03P145494 GC03P149430 GC03P149827 GC03P149866 GC03P150028 GC03P145918


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CPB1 Gene:
Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2
forms differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein
and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated
in pancreatic carcinoma. (provided by RefSeq, Jul 2008)

GeneCards Summary for CPB1 Gene: 
CPB1 (carboxypeptidase B1 (tissue)) is a protein-coding gene. Diseases associated with CPB1 include trachea leiomyoma, and tricuspid valve insufficiency, and among its related super-pathways are Renin-angiotensin system and Insulin Processing. GO annotations related to this gene include metallocarboxypeptidase activity and carboxypeptidase activity. An important paralog of this gene is CPO.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPB1 gene promoter:
         HOXA9   HOXA9B   NCX/Ncx   Lmo2   C/EBPalpha   POU2F1   HNF-1   POU2F1a   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CPB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q24   Ensembl cytogenetic band:  3q24   HGNC cytogenetic band: 3q24

CPB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPB1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P148508:  view genomic region     (about GC identifiers)

Start:
148,508,889 bp from pter      End:
148,577,974 bp from pter
Size:
69,086 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CBPB1_HUMAN, P15086 (See protein sequence)
Recommended Name: Carboxypeptidase B precursor  
Size: 417 amino acids; 47368 Da
Cofactor: Binds 1 zinc ion per subunit
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for CPB1:
1KWM (3D)        1ZLI (3D)    
Secondary accessions: O60834 Q53XJ0 Q96BQ8

Explore the universe of human proteins at neXtProt for CPB1: NX_P15086

Explore proteomics data for CPB1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P15086

  • 4/7 DME Specific Peptides for CPB1 (P15086) (see all 7)
     FELRDTG  WETIEAW  YTYGPGA  HAREWIS 

    CPB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CPB1 Protein Expression
    REFSEQ proteins: NP_001862.2  
    ENSEMBL proteins: 
     ENSP00000417222   ENSP00000419114   ENSP00000417117   ENSP00000419427   ENSP00000282957  
    Reactome Protein details: P15086
    Human Recombinant Protein Products for CPB1: 
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    Sino Biological Recombinant Protein for CPB1
    Sino Biological Cell Lysate for CPB1 
    ProSpec Recombinant Protein for CPB1
    Cloud-Clone Corp. Proteins for CPB1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    CPB1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for CPB1 
    Cloud-Clone Corp. CLIAs for CPB1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: Carboxypeptidase B1 (tissue) 
    Metallocarboxypeptidases

    3 InterPro protein domains:
     IPR003146 Prot_inh_M14A
     IPR000834 Peptidase_M14
     IPR009020 Prot_inh_propept

    Graphical View of Domain Structure for InterPro Entry P15086

    ProtoNet protein and cluster: P15086

    2 Blocks protein domains:
    IPB000834 Zinc carboxypeptidase A metalloprotease (M14)
    IPB003146 Carboxypeptidase activation peptide


    UniProtKB/Swiss-Prot: CBPB1_HUMAN, P15086
    Similarity: Belongs to the peptidase M14 family


    CPB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBPB1_HUMAN, P15086
    Catalytic activity: Preferential release of a C-terminal lysine or arginine amino acid

         Genatlas biochemistry entry for CPB1:
    carboxypeptidase B1 (tissue)

         Enzyme Numbers (IUBMB): EC 3.4.17.21 2 EC 3.4.172

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004180carboxypeptidase activity TAS1370825
    GO:0004181metallocarboxypeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    CPB1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CPB1:
     Decreased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CPB1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CPB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPB1 
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    miRNA
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPB1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CPB1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Renin-angiotensin system
    Metabolism of Angiotensinogen to Angiotensins0.43
    2Insulin Processing
    Peptide hormone metabolism0.39
    3Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    4Protein digestion and absorption
    Protein digestion and absorption
    5Pancreatic secretion
    Pancreatic secretion

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3        Reactome Pathways for CPB1
        Metabolism of Angiotensinogen to Angiotensins
    Metabolism of proteins
    Peptide hormone metabolism


    2         Kegg Pathways  (Kegg details for CPB1):
        Pancreatic secretion
    Protein digestion and absorption


    CPB1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CPB1

    2 Interacting proteins for CPB1 (P150863) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619813I2D: score=2 
    KIAA1279Q96EK53I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    CPB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CPB1 for compounds           About GeneDecksing

    EMD Millipore small molecules for CPB1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CPB1 (CBPB1)

    1 HMDB Compound for CPB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--

    8 DrugBank Compounds for CPB1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2S)-2-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-3-[(S)-HYDROXY(3-PHENYLPROPYL)PHOSPHORYL]PROPANOIC ACID-- --target--10592235
    (2S)-2-[3-(AMINOMETHYL)PHENYL]-3-[(R)-HYDROXY{(1R)-2-METHYL-1-[(PHENYLSULFONYL)AMINO]PROPYL}PHOSPHORYL]PROPANOIC ACID-- --target--10592235
    (2S)-2-[3-(AMINOMETHYL)PHENYL]-3-[(R)-[(1R)-1-{[(BENZYLOXY)CARBONYL]AMINO}-2-METHYLPROPYL](HYDROXY)PHOSPHORYL]PROPANOIC ACID-- --target--10592235
    (2S)-2-[3-(AMINOMETHYL)PHENYL]-3-{(R)-HYDROXY[(1R)-2-METHYL-1-{[(3-PHENYLPROPYL)SULFONYL]AMINO}PROPYL]PHOSPHORYL}PROPANOIC ACID-- --target--10592235
    (2S)-2-[3-(AMINOMETHYL)PHENYL]-3-{(S)-HYDROXY[(1R)-2-METHYL-1-{[(2-PHENYLETHYL)SULFONYL]AMINO}PROPYL]PHOSPHORYL}PROPANOIC ACID-- --target--10592235
    (5R,6S,8S)-8-[3-(AMINOMETHYL)PHENYL]-6-HYDROXY-5-ISOPROPYL-3-OXO-1-PHENYL-2,7-DIOXA-4-AZA-6-PHOSPHANONAN-9-OIC ACID 6-OXIDE-- --target--10592235
    2-(3-GUANIDINOPHENYL)-3-MERCAPTOPROPANOIC ACID-- --target--10592235
    Citric Acid-- 77-92-9target----

    3 Novoseek inferred chemical compound relationships for CPB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pcbs 59.3 31 7727441 (4), 9261609 (4), 1370825 (3), 8322019 (2) (see all 5)
    lysine 51.1 6 11127872 (2), 1776140 (1), 7727441 (1), 11027681 (1)
    arginine 9.44 3 7727441 (1), 8428004 (1)

    Search CenterWatch for drugs/clinical trials and news about CPB1 / CBPB1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CPB1 gene: 
    NM_001871.2  

    Unigene Cluster for CPB1:

    Carboxypeptidase B1 (tissue)
    Hs.477891  [show with all ESTs]
    Unigene Representative Sequence: CR749369
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491148(uc003ewl.3) ENST00000494888 ENST00000462345 ENST00000468341
    ENST00000465718 ENST00000484877 ENST00000473621 ENST00000498639 ENST00000476847
    ENST00000282957
    miRNA
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    Additional mRNA sequence: 

    AJ224866.1 AK313940.1 BC015338.1 BT009910.1 CR749369.1 M81057.1 

    24/25 DOTS entries (see all 25):

    DT.86858510  DT.100033489  DT.120929362  DT.100793616  DT.102833416  DT.91793463  DT.100793609  DT.121641595 
    DT.95248364  DT.100793618  DT.100033483  DT.99938959  DT.100793619  DT.120929274  DT.120929288  DT.120929299 
    DT.120929309  DT.120929328  DT.120929345  DT.120929348  DT.120929370  DT.120929371  DT.120929372  DT.95248361 

    24/474 AceView cDNA sequences (see all 474):

    BQ788040 CA776267 CA950367 CA865622 CA865889 CA772140 CR623808 CA840967 
    BC015338 BQ417229 BM310685 CA773892 CB068014 AA363790 AA835579 BQ287891 
    BQ778158 BU785542 BM090587 BU952568 BM313236 CA868303 CA777529 BE045796 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CPB1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b
    SP1:              -                 -                                                           -     -                           
    SP2:              -                 -           -     -     -     -     -     -                 -     -                           
    SP3:                                                                                                                              
    SP4:                                -                                                                                             
    SP5:                                                                                                  -                           


    ECgene alternative splicing isoforms for CPB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CPB1 expression in normal human tissues (normalized intensities)      CPB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGAGAGTG
    CPB1 Expression
    About this image


    CPB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
             Pancreatic Islet   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             neonatal small intestine   
     
     Adrenal Gland (Endocrine System)
             adrenal cortex   
     
     Colon (Gastrointestinal Tract)
             rectum mucosa   
     
     Ovary (Reproductive System)
             oocyte   

    See CPB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CPB1

    SOURCE GeneReport for Unigene cluster: Hs.477891

    UniProtKB/Swiss-Prot: CBPB1_HUMAN, P15086
    Tissue specificity: Pancreas

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CPB1 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpb11 , 5 carboxypeptidase B1 (tissue)1, 5 78.07(n)1
    74.46(a)1
      3 (6.29 cM)5
    767031  NM_029706.11  NP_083982.11 
     202482645 
    chicken
    (Gallus gallus)
    Aves CPB11 carboxypeptidase B1 (tissue) 69.06(n)
    67.87(a)
      424888  XM_422699.3  XP_422699.1 
    lizard
    (Anolis carolinensis)
    Reptilia CPB16
    Uncharacterized protein
    70(a)
    1 ↔ 1
    3(19235202-19261456)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.260012 Xenopus laevis transcribed sequence with weak similarity more 74.57(n)    CF284662.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb60d072 wufb60d07 75.19(n)   322412  CA470865.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG184173
    CG40171
    CG40171 35(a)
    (best of 16)3
    45.84(n)1
    37.02(a)1
      65F113
    342961  NM_135465.31  NP_609309.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y18H1A.93   -- 33(a)
    (best of 6)
      I(748486-756927)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ECM146
    Putative metalloprotease with similarity to the zi...
    26(a)
    1 → many
    VIII(368502-369794)


    ENSEMBL Gene Tree for CPB1 (if available)
    TreeFam Gene Tree for CPB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CPB1 gene
    CPO2  CPA22  CPA12  CPA62  CPA32  CPA52  CPB22  CPA42  
    9 SIMAP similar genes for CPB1 using alignment to 4 protein entries:     CBPB1_HUMAN (see all proteins):
    DKFZp779K1333    CPO    CPA1    CPA3    CPA6    CPB2
    CPA4    CPA2    CPA5

    CPB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/779 SNPs in CPB1 are shown (see all 779)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1440462161,2
    --148543643(+) ACATTG/TCTAGA 1 -- us2k10--------
    rs2008408891,2
    C--148543837(+) ATTTT-/AAAAAT 1 -- us2k10--------
    rs1995150321,2
    --148543839(+) TTTAA-/AAATG 
            
    AATGA
    1 -- us2k10--------
    rs1412472651,2
    C--148543841(+) TAAAA-/ATGAAT
            
    GATTC
    1 -- us2k10--------
    rs2005429831,2
    C--148543843(+) AAAAT-/GAATG 
            
    ATTCA
    1 -- us2k10--------
    rs1913460411,2
    --148543864(+) ACACTA/GAAGAC 1 -- us2k10--------
    rs606844571,2
    C,F--148544021(+) TATCAA/GAATTA 1 -- us2k13Minor allele frequency- G:0.12WA NA 240
    rs117106331,2
    C,F,H--148544051(+) acataA/Ccatta 1 -- us2k111Minor allele frequency- C:0.24NS EA NA CSA WA 760
    rs787772171,2
    F--148544079(+) GCCACA/TTACTG 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs766865061,2
    C,F--148544107(+) ATATAT/GTTCTA 1 -- us2k11Minor allele frequency- G:0.05WA 118

    HapMap Linkage Disequilibrium report for CPB1 (148508889 - 148577974 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CPB1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2507087CNV Deletion19546169
    esv1937920CNV Deletion18987734
    esv1368988CNV Deletion17803354
    esv2726034CNV Deletion23290073
    esv998869CNV Deletion20482838
    esv5048CNV Deletion18987735
    dgv127n6CNV Loss16902084
    nsv829751CNV Loss17160897
    esv6949CNV Loss19470904

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 114852    OMIM disorders: --

    13 diseases for CPB1:    About MalaCards
    trachea leiomyoma    tricuspid valve insufficiency    pancreatitis    acute pancreatitis
    leiomyoma    diabetes mellitus    type 1 diabetes    hepatitis b
    hypertension    alcoholism    pancreatic cancer    hepatitis
    endotheliitis

    4 diseases from the University of Copenhagen DISEASES database for CPB1:
    Tricuspid valve insufficiency     Pulmonary hypertension     Pancreatitis     Trachea leiomyoma

    CPB1 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for CPB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatitis alcoholic 66.6 1 7510410 (1)
    acute pancreatitis 64.8 15 1688389 (3), 8322019 (3), 7510410 (2), 9524066 (1) (see all 6)
    pancreatitis 50.6 9 1688389 (4), 7624299 (3), 9261609 (2)
    pancreatic cancer 44.1 2 1688389 (1), 9261609 (1)
    diabetes mellitus insulin-dependent 24.7 1 1584208 (1)

    Genetic Association Database (GAD): CPB1
    Human Genome Epidemiology (HuGE) Navigator: CPB1 (1 document)

    Export disorders for CPB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CPB1 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with CPB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a cDNA encoding a human serum marker for acute pancreatitis. Identification of pancreas-specific protein as pancreatic procarboxypeptidase B. (PubMed id 1370825)1, 2, 9 Yamamoto K.K....French C.K. (1992)
    2. Comparative analysis of the sequences and three-dimensional models of human procarboxypeptidases A1, A2 and B. (PubMed id 9524066)1, 2, 9 Aloy P....Aviles F.X. (1998)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Human procarboxypeptidase B: three-dimensional structure and implications for thrombin-activatable fibrinolysis inhibitor (TAFI). (PubMed id 12162965)1, 2 Barbosa-Pereira P.J.... Vendrell J. (2002)
    6. Purification and properties of five different forms of human procarboxypeptidases. (PubMed id 2920728)1, 2 Pascual R.... Aviles F.X. (1989)
    7. Isoforms of procarboxypeptidase B, (pancreas-specific protein, PASP) in human serum, pancreatic tissue and juice. (PubMed id 8322019)1, 9 Fernstad R....Pousette A. (1993)
    8. The NMR structure and dynamics of the two-domain tick carboxypeptidase inhibitor reveal flexibility in its free form and stiffness upon binding to human carboxypeptidase B. (PubMed id 18558717)1 Pantoja-Uceda D....Blanco F.J. (2008)
    9. TAFI and pancreatic carboxypeptidase B modulate in vitro capillary tube formation by human microvascular endothelial cells. (PubMed id 17673703)1 Guimaraes A.H....Rijken D.C. (2007)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1360 HGNC: 2299 AceView: CPB1 Ensembl:ENSG00000153002 euGenes: HUgn1360
    ECgene: CPB1 Kegg: 1360 H-InvDB: CPB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CPB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CPB1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CPB1 gene:
    Search GeneIP for patents involving CPB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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