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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPB1 Gene

protein-coding   GIFtS: 65
GCID: GC03P148508

carboxypeptidase B1 (tissue)
 Explore 8 diseases affiliated with
CPB1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CPB1    

Aliases
for CPB1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Carboxypeptidase B1 (Tissue)1 2     Carboxypeptidase B2
Pancreas-Specific Protein2 3     Pancreatic Carboxypeptidase B2
CPB2 3     Procarboxypeptidase B2
PASP2 3     Protaminase1
PCPB2 3     Tissue Carboxypeptidase B2
EC 3.4.17.23 8     EC 3.4.178

External Ids:    HGNC: 22991   Entrez Gene: 13602   Ensembl: ENSG000001530027   OMIM: 1148525   UniProtKB: P150863   

Export aliases for CPB1 gene to outside databases

Previous GC identifers: GC03P145494 GC03P149430 GC03P149827 GC03P149866 GC03P150028 GC03P145918


Summaries
for CPB1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CPB1:
Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms
differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein and is a
useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic
carcinoma. (provided by RefSeq, Jul 2008)




Genomic Views
for CPB1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPB1 gene promoter:
         HOXA9   HOXA9B   NCX/Ncx   Lmo2   C/EBPalpha   POU2F1   HNF-1   POU2F1a   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CPB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CPB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q24   Ensembl cytogenetic band:  3q24   HGNC cytogenetic band: 3q24

CPB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPB1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P148508:  view genomic region     (about GC identifiers)

Start:
 148,508,889 bp from pter      End:
 148,577,974 bp from pter
Size:
 69,086 bases      Orientation:
 plus strand

Proteins
for CPB1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CBPB1_HUMAN, P15086 (See protein sequence)
Recommended Name: Carboxypeptidase B precursor  
Size: 417 amino acids; 47368 Da
Cofactor: Binds 1 zinc ion per subunit
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for CPB1:
1KWM (3D)        1ZLI (3D)    
Secondary accessions: O60834 Q53XJ0 Q96BQ8

Explore the universe of human proteins at neXtProt for CPB1: NX_P15086

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P15086

    • 4/7 DME Specific Peptides for CPB1 (P15086) (see all 7)
     FELRDTG  WETIEAW  YTYGPGA  HAREWIS 

    CPB1 Protein expression data from MOPED and PaxDb:    About this image 
    CPB1 Protein Expression
    REFSEQ proteins: NP_001862.2  
    ENSEMBL proteins: 
     ENSP00000417222   ENSP00000419114   ENSP00000417117   ENSP00000419427   ENSP00000282957  

    Human Recombinant Protein Products for CPB1: 
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    Novus Biologicals CPB1 Proteins
    Novus Biologicals CPB1 Lysates
    Sino Biological Recombinant Protein for CPB1
    ProSpec Recombinant Protein for CPB1
    Uscn Proteins for CPB1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    CPB1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CPB1

    Protein Domains /
    Families
    for CPB1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CPB1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR003146 Prot_inh_M14A
     IPR000834 Peptidase_M14
     IPR009020 Prot_inh_propept

    Graphical View of Domain Structure for InterPro Entry P15086

    ProtoNet protein and cluster: P15086

    2 Blocks protein families:
    IPB000834 Zinc carboxypeptidase A metalloprotease (M14)
    IPB003146 Carboxypeptidase activation peptide


    UniProtKB/Swiss-Prot: CBPB1_HUMAN, P15086
    Similarity: Belongs to the peptidase M14 family


    Function
    for CPB1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBPB1_HUMAN, P15086
    Catalytic activity: Preferential release of a C-terminal lysine or arginine amino acid

         Genatlas biochemistry entry for CPB1:
    carboxypeptidase B1 (tissue)

         Enzyme Numbers (IUBMB): EC 3.4.17.21 2 EC 3.4.172

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004180carboxypeptidase activity TAS1370825
    GO:0004181metallocarboxypeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    CPB1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CPB1:
     Decreased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CPB1 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: CPB1
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    SwitchGear 3'UTR luciferase reporter plasmid: CPB1 3' UTR sequence
    Inhib. RNA
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    Sirion Biotech Custom design and validation of potent shRNA sequences against CPB1 

    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPB1


    Pathways & Interactions
    for CPB1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Protein digestion and absorption
    		Protein digestion and absorption1.00
    2Pancreatic secretion
    		Pancreatic secretion1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    2         Kegg Pathways  (Kegg details for CPB1):
        Pancreatic secretion
    Protein digestion and absorption


    CPB1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CPB1

    2 Interacting proteins for CPB1 (P150863) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619813I2D: score=2 
    KIAA1279Q96EK53I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    CPB1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CPB1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CPB1 for compounds           About GeneDecksing

    EMD Millipore small molecules for CPB1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CPB1

    1 HMDB Compound for CPB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--

    8 DrugBank Compounds for CPB1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2S)-2-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-3-[(S)-HYDROXY(3-PHENYLPROPYL)PHOSPHORYL]PROPANOIC ACID-- --target--10592235
    (2S)-2-[3-(AMINOMETHYL)PHENYL]-3-[(R)-HYDROXY{(1R)-2-METHYL-1-[(PHENYLSULFONYL)AMINO]PROPYL}PHOSPHORYL]PROPANOIC ACID-- --target--10592235
    (2S)-2-[3-(AMINOMETHYL)PHENYL]-3-[(R)-[(1R)-1-{[(BENZYLOXY)CARBONYL]AMINO}-2-METHYLPROPYL](HYDROXY)PHOSPHORYL]PROPANOIC ACID-- --target--10592235
    (2S)-2-[3-(AMINOMETHYL)PHENYL]-3-{(R)-HYDROXY[(1R)-2-METHYL-1-{[(3-PHENYLPROPYL)SULFONYL]AMINO}PROPYL]PHOSPHORYL}PROPANOIC ACID-- --target--10592235
    (2S)-2-[3-(AMINOMETHYL)PHENYL]-3-{(S)-HYDROXY[(1R)-2-METHYL-1-{[(2-PHENYLETHYL)SULFONYL]AMINO}PROPYL]PHOSPHORYL}PROPANOIC ACID-- --target--10592235
    (5R,6S,8S)-8-[3-(AMINOMETHYL)PHENYL]-6-HYDROXY-5-ISOPROPYL-3-OXO-1-PHENYL-2,7-DIOXA-4-AZA-6-PHOSPHANONAN-9-OIC ACID 6-OXIDE-- --target--10592235
    2-(3-GUANIDINOPHENYL)-3-MERCAPTOPROPANOIC ACID-- --target--10592235
    Citric Acid-- 77-92-9target----

    3 Novoseek chemical compound relationships for CPB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pcbs 59.3 31 7727441 (4), 9261609 (4), 1370825 (3), 8322019 (2) (see all 5)
    lysine 51.1 6 11127872 (2), 1776140 (1), 7727441 (1), 11027681 (1)
    arginine 9.44 3 7727441 (1), 8428004 (1)

    Search CenterWatch for drugs/clinical trials and news about CPB1 / CBPB1 

    Transcripts
    for CPB1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CPB1 gene: 
    NM_001871.2  

    Unigene Cluster for CPB1:

    Carboxypeptidase B1 (tissue)
    Hs.477891  [show with all ESTs]
    Unigene Representative Sequence: CR749369
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491148(uc003ewl.3) ENST00000494888 ENST00000462345 ENST00000468341
    ENST00000465718 ENST00000484877 ENST00000473621 ENST00000498639 ENST00000476847
    ENST00000282957

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPB1
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    SwitchGear 3'UTR luciferase reporter plasmid: CPB1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPB1 (see all 7)
    OriGene shRNA RFP: CPB1
    OriGene siRNA: CPB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPB1
    Sirion Biotech Custom design and validation of potent shRNA sequences against CPB1 
    Clone
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    GenScript: all cDNA clones in your preferred vector: CPB1 (NM_001871)
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    Additional cDNA sequence: 

    AJ224866.1 AK313940.1 BC015338.1 BT009910.1 CR749369.1 M81057.1 

    24/25 DOTS entries (see all 25):

    DT.86858510  DT.100033489  DT.120929362  DT.100793616  DT.102833416  DT.91793463  DT.100793609  DT.121641595 
    DT.95248364  DT.100793618  DT.100033483  DT.99938959  DT.100793619  DT.120929274  DT.120929288  DT.120929299 
    DT.120929309  DT.120929328  DT.120929345  DT.120929348  DT.120929370  DT.120929371  DT.120929372  DT.95248361 

    24/474 AceView cDNA sequences (see all 474):

    CB068014 BI325027 CA776267 BU074501 CA950367 CA941264 AA363749 BM313236 
    BQ778158 CA773892 BU072780 BU952568 CA778131 BM090815 BE045796 BQ778328 
    CA772437 BQ776523 BM091383 CB070362 AA845160 BQ778502 CA844236 CA865622 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CPB1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b
    SP1:              -                 -                                                           -     -                           
    SP2:              -                 -           -     -     -     -     -     -                 -     -                           
    SP3:                                                                                                                              
    SP4:                                -                                                                                             
    SP5:                                                                                                  -                           


    ECgene alternative splicing isoforms for CPB1

    Expression
    for CPB1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CPB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCAGAGAGTG
    CPB1 Expression
    About this image

    CPB1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PancreasIslets of LangerhansMature Beta CellsPancreas
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See CPB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CPB1

    SOURCE GeneReport for Unigene cluster: Hs.477891

    UniProtKB/Swiss-Prot: CBPB1_HUMAN, P15086
    Tissue specificity: Pancreas

        SABiosciences Custom PCR Arrays for CPB1
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPB1

    Orthologs
    for CPB1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CPB1 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CPB11 carboxypeptidase B1 (tissue) 69.06(n)
    67.87(a)    		   424888  XM_422699.3  XP_422699.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CPB16
    		 --
    		 70(a)
    		 1 ↔ 1
    		 3(19235285-19261444)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.260012 Xenopus laevis transcribed sequence with weak similarity more 74.57(n)    CF284662.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb60d072 wufb60d07 75.19(n)   322412  CA470865.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG184173
    CG40171    		 CG40171 35(a)
    (best of 16)3
    45.84(n)1
    37.02(a)1    		   65F113
    342961  NM_135465.31  NP_609309.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y18H1A.93   -- 33(a)
    (best of 6)    		   I(748486-756927)   --


    ENSEMBL Gene Tree for CPB1 (if available)
    TreeFam Gene Tree for CPB1 (if available) 

    Paralogs
    for CPB1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CPB1 gene
    CPO2  CPA22  CPA12  CPA62  CPA32  CPA52  CPB22  CPA42  
    9 SIMAP similar genes for CPB1 using alignment to 4 protein entries:     CBPB1_HUMAN (see all proteins):
    DKFZp779K1333    CPO    CPA1    CPA3    CPA6    CPB2
    CPA4    CPA2    CPA5

    CPB1 for paralogs           About GeneDecksing



    Genomic Variants
    for CPB1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/643 NCBI SNPs in CPB1 are shown (see all 643)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1440462161,2
    		--148543643(+) ACATTG/TCTAGA 1 -- us2k10--------
    rs2008408891,2
    		--148543837(+) ATTTT-/AAAAAT 1 -- us2k10--------
    rs1995150321,2
    		--148543839(+) TTTAA-/AAATG 
                AATGA     		1 -- us2k10--------
    rs1412472651,2
    		C--148543841(+) TAAAA-/ATGAAT
                GATTC     		1 -- us2k10--------
    rs2005429831,2
    		--148543843(+) AAAAT-/GAATG 
                ATTCA     		1 -- us2k10--------
    rs1913460411,2
    		--148543864(+) ACACTA/GAAGAC 1 -- us2k10--------
    rs606844571,2
    		C--148544021(+) TATCAA/GAATTA 1 -- us2k13Minor allele frequency- G:0.12WA NA 240
    rs117106331,2
    		C,F,H--148544051(+) ACATAA/CCATTA 1 -- us2k111Minor allele frequency- C:0.24NS EA NA CSA WA 760
    rs787772171,2
    		F--148544079(+) GCCACA/TTACTG 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs766865061,2
    		C,F--148544107(+) ATATAT/GTTCTA 1 -- us2k11Minor allele frequency- G:0.05WA 118

    HapMap Linkage Disequilibrium report for CPB1 (148508889 - 148577974 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for CPB1
         1 CNV: 98482
         7 Indels: 27182 12340 41961 62111 46305 12341 40570

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    Disorders / Diseases
    for CPB1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CPB1 for disorders           About GeneDecksing

    OMIM gene information: 114852    OMIM disorders: --

    8 diseases for CPB1:    About MalaCards
    pancreatitis    acute pancreatitis    pancreatic carcinoma    carcinoma
    diabetes mellitus    hepatitis b    hermaphroditism    hepatitis

    4 diseases from the University of Copenhagen DISEASES database for CPB1:
    Tricuspid valve insufficiency     Pulmonary hypertension     Pancreatitis     Trachea leiomyoma

    5 Novoseek disease relationships for CPB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatitis alcoholic 66.6 1 7510410 (1)
    acute pancreatitis 64.8 15 1688389 (3), 8322019 (3), 7510410 (2), 9524066 (1) (see all 6)
    pancreatitis 50.6 9 1688389 (4), 7624299 (3), 9261609 (2)
    pancreatic cancer 44.1 2 1688389 (1), 9261609 (1)
    diabetes mellitus insulin-dependent 24.7 1 1584208 (1)

    Human Genome Epidemiology (HuGE) Navigator: CPB1 (1 document)

    Export disorders for CPB1 gene to outside databases

    Publications
    for CPB1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CPB1 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with CPB1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a cDNA encoding a human serum marker for acute pancreatitis. Identification of pancreas-specific protein as pancreatic procarboxypeptidase B. (PubMed id 1370825)1, 2, 9 Yamamoto K.K....French C.K. (1992)
    2. Comparative analysis of the sequences and three-dimensional models of human procarboxypeptidases A1, A2 and B. (PubMed id 9524066)1, 2, 9 Aloy P....Aviles F.X. (1998)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Human procarboxypeptidase B: three-dimensional structure and implications for thrombin-activatable fibrinolysis inhibitor (TAFI). (PubMed id 12162965)1, 2 Barbosa-Pereira P.J.... Vendrell J. (2002)
    5. Purification and properties of five different forms of human procarboxypeptidases. (PubMed id 2920728)1, 2 Pascual R.... Aviles F.X. (1989)
    6. Isoforms of procarboxypeptidase B, (pancreas-specific protein, PASP) in human serum, pancreatic tissue and juice. (PubMed id 8322019)1, 9 Fernstad R....Pousette A. (1993)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. The NMR structure and dynamics of the two-domain tick carboxypeptidase inhibitor reveal flexibility in its free form and stiffness upon binding to human carboxypeptidase B. (PubMed id 18558717)1 Pantoja-Uceda D....Blanco F.J. (2008)
    9. TAFI and pancreatic carboxypeptidase B modulate in vitro capillary tube formation by human microvascular endothelial cells. (PubMed id 17673703)1 Guimaraes A.H....Rijken D.C. (2007)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for CPB1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing CPB1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1360 HGNC: 2299 AceView: CPB1 Ensembl:ENSG00000153002 euGenes: HUgn1360
    ECgene: CPB1 Kegg: 1360 H-InvDB: CPB1

    Other Databases showing CPB1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CPB1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CPB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CPB1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CPB1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CPB1 gene:
    Search GeneIP for patents involving CPB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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