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Aliases for CPB1 Gene

Aliases for CPB1 Gene

  • Carboxypeptidase B1 (Tissue) 2 3
  • Pancreatic Carboxypeptidase B 2 3
  • Tissue Carboxypeptidase B 2 3
  • Pancreas-Specific Protein 3 4
  • Protaminase 2 3
  • EC 3.4.17.2 4 64
  • PASP 3 4
  • PCPB 3 4
  • CPB 3 4
  • Procarboxypeptidase B 3
  • Carboxypeptidase B 3
  • EC 3.4.17 64

External Ids for CPB1 Gene

Summaries for CPB1 Gene

Entrez Gene Summary for CPB1 Gene

  • Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPB1 Gene

CPB1 (Carboxypeptidase B1 (Tissue)) is a Protein Coding gene. Diseases associated with CPB1 include tricuspid valve insufficiency and trachea leiomyoma. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Pancreatic secretion. GO annotations related to this gene include metallocarboxypeptidase activity and carboxypeptidase activity. An important paralog of this gene is CPA3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPB1 Gene

Genomics for CPB1 Gene

Genomic Location for CPB1 Gene

Start:
148,791,102 bp from pter
End:
148,860,192 bp from pter
Size:
69,091 bases
Orientation:
Plus strand

Genomic View for CPB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPB1 Gene

Regulatory Elements for CPB1 Gene

Proteins for CPB1 Gene

  • Protein details for CPB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15086-CBPB1_HUMAN
    Recommended name:
    Carboxypeptidase B
    Protein Accession:
    P15086
    Secondary Accessions:
    • O60834
    • Q53XJ0
    • Q96BQ8

    Protein attributes for CPB1 Gene

    Size:
    417 amino acids
    Molecular mass:
    47368 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CPB1 Gene

neXtProt entry for CPB1 Gene

Proteomics data for CPB1 Gene at MOPED

Selected DME Specific Peptides for CPB1 Gene

Post-translational modifications for CPB1 Gene

No Post-translational modifications

Other Protein References for CPB1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CPB1 Gene

Gene Families for CPB1 Gene

UniProtKB/Swiss-Prot:

CBPB1_HUMAN
Family:
  • Belongs to the peptidase M14 family.:
    • P15086
genes like me logo Genes that share domains with CPB1: view

Function for CPB1 Gene

Molecular function for CPB1 Gene

GENATLAS Biochemistry: carboxypeptidase B1 (tissue)
UniProtKB/Swiss-Prot CatalyticActivity: Preferential release of a C-terminal lysine or arginine amino acid

Enzyme Numbers (IUBMB) for CPB1 Gene

Gene Ontology (GO) - Molecular Function for CPB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity TAS 1370825
GO:0004181 metallocarboxypeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CPB1: view

Phenotypes for CPB1 Gene

genes like me logo Genes that share phenotypes with CPB1: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CPB1 Gene

Localization for CPB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPB1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPB1 Gene COMPARTMENTS Subcellular localization image for CPB1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
cytosol 1
endosome 1
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CPB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CPB1: view

Pathways for CPB1 Gene

genes like me logo Genes that share pathways with CPB1: view

Pathways by source for CPB1 Gene

Gene Ontology (GO) - Biological Process for CPB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with CPB1: view

Transcripts for CPB1 Gene

Unigene Clusters for CPB1 Gene

Carboxypeptidase B1 (tissue):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPB1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b
SP1: - - - -
SP2: - - - - - - - - - -
SP3:
SP4: -
SP5: -
SP6:

Relevant External Links for CPB1 Gene

GeneLoc Exon Structure for
CPB1
ECgene alternative splicing isoforms for
CPB1

Expression for CPB1 Gene

mRNA expression in normal human tissues for CPB1 Gene

mRNA differential expression in normal tissues according to GTEx for CPB1 Gene

This gene is overexpressed in Pancreas (52.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CPB1 Gene

SOURCE GeneReport for Unigene cluster for CPB1 Gene Hs.477891

mRNA Expression by UniProt/SwissProt for CPB1 Gene

P15086-CBPB1_HUMAN
Tissue specificity: Pancreas
genes like me logo Genes that share expressions with CPB1: view

Orthologs for CPB1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CPB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPB1 36
  • 98.96 (n)
  • 98.32 (a)
CPB1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPB1 36
  • 86.25 (n)
  • 82.49 (a)
CPB1 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPB1 36
  • 87.66 (n)
  • 84.34 (a)
CPB1 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpb1 36
  • 78.07 (n)
  • 74.46 (a)
Cpb1 16
Cpb1 37
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPB1 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 73 (a)
OneToMany
-- 37
  • 73 (a)
OneToMany
-- 37
  • 78 (a)
OneToMany
-- 37
  • 59 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cpb1 36
  • 79.2 (n)
  • 76.14 (a)
chicken
(Gallus gallus)
Aves CPB1 36
  • 69.06 (n)
  • 67.87 (a)
CPB1 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPB1 37
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.26001 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494117 36
  • 58.82 (n)
  • 51.46 (a)
Str.5708 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2214 36
zebrafish
(Danio rerio)
Actinopterygii cpb1 36
  • 69.44 (n)
  • 67.8 (a)
cpb1 37
  • 58 (a)
OneToMany
wufb60d07 36
fruit fly
(Drosophila melanogaster)
Insecta CG12374 37
  • 26 (a)
ManyToMany
CG14820 37
  • 29 (a)
ManyToMany
CG17633 37
  • 30 (a)
ManyToMany
CG18417 37
  • 32 (a)
ManyToMany
CG18585 37
  • 31 (a)
ManyToMany
CG2915 37
  • 27 (a)
ManyToMany
CG32379 37
  • 30 (a)
ManyToMany
CG4017 36
  • 45.93 (n)
  • 37.02 (a)
CG4017 37
  • 33 (a)
ManyToMany
CG4408 37
  • 25 (a)
ManyToMany
CG7025 37
  • 32 (a)
ManyToMany
CG8539 37
  • 25 (a)
ManyToMany
CG8560 37
  • 32 (a)
ManyToMany
CG8562 37
  • 32 (a)
ManyToMany
CG8563 37
  • 27 (a)
ManyToMany
CG8564 37
  • 18 (a)
ManyToMany
CG3097 38
  • 28 (a)
CG8539 38
  • 28 (a)
CG3108 38
  • 35 (a)
CG8560 38
  • 32 (a)
CG18585 38
  • 32 (a)
CG15769 38
  • 30 (a)
CG14820 38
  • 30 (a)
CG18415 38
  • 29 (a)
CG17633 38
  • 33 (a)
CG8562 38
  • 32 (a)
CG2915 38
  • 31 (a)
CG12374 38
  • 30 (a)
CG4408 38
  • 28 (a)
CG4017 38
  • 35 (a)
CG7025 38
  • 32 (a)
CG18417 38
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea F02D8.4 37
  • 28 (a)
ManyToMany
suro-1 37
  • 20 (a)
ManyToMany
T06A4.1 37
  • 24 (a)
ManyToMany
T06A4.3 37
  • 25 (a)
ManyToMany
W01A8.6 37
  • 27 (a)
ManyToMany
Y18H1A.9 37
  • 29 (a)
ManyToMany
Y47G6A.19 37
  • 28 (a)
ManyToMany
ZC434.9 37
  • 19 (a)
ManyToMany
R11A5.7 38
  • 32 (a)
Y18H1A.9 38
  • 33 (a)
Y59C2A.1 38
  • 29 (a)
ZC434.9 38
  • 31 (a)
Y47G6A.19 38
  • 31 (a)
W01A8.6 38
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM14 37
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 36 (a)
ManyToMany
-- 37
  • 35 (a)
ManyToMany
CSA.11311 37
  • 35 (a)
ManyToMany
CSA.4005 37
  • 18 (a)
ManyToMany
Species with no ortholog for CPB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPB1 Gene

ENSEMBL:
Gene Tree for CPB1 (if available)
TreeFam:
Gene Tree for CPB1 (if available)

Paralogs for CPB1 Gene

Paralogs for CPB1 Gene

Selected SIMAP similar genes for CPB1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CPB1: view

Variants for CPB1 Gene

Sequence variations from dbSNP and Humsavar for CPB1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs968894 -- 148,852,493(+) AATAA(A/C)TATAA intron-variant
rs1059502 - 148,844,523(+) TTCTC(A/G)ACAAG missense, reference
rs1318579 -- 148,835,773(+) TAGCC(G/T)ATATA intron-variant
rs1352897 -- 148,825,624(+) ATATT(A/G)ACTAT intron-variant
rs1356259 -- 148,857,654(+) CACAG(C/T)AAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPB1 Gene

Variant ID Type Subtype PubMed ID
nsv829751 CNV Loss 17160897
esv2507087 CNV Deletion 19546169
esv1937920 CNV Deletion 18987734
esv5048 CNV Deletion 18987735
esv2726034 CNV Deletion 23290073
dgv127n6 CNV Loss 16902084
esv998869 CNV Deletion 20482838
esv6949 CNV Loss 19470904
esv1368988 CNV Deletion 17803354

Relevant External Links for CPB1 Gene

HapMap Linkage Disequilibrium report
CPB1

Disorders for CPB1 Gene

(5) Novoseek inferred disease relationships for CPB1 Gene

Disease -log(P) Hits PubMed IDs
pancreatitis alcoholic 66.6 1
acute pancreatitis 64.8 11
pancreatitis 50.6 9
pancreatic cancer 44.1 2
diabetes mellitus insulin-dependent 24.7 1

Relevant External Links for CPB1

Genetic Association Database (GAD)
CPB1
Human Genome Epidemiology (HuGE) Navigator
CPB1
genes like me logo Genes that share disorders with CPB1: view

No data available for UniProtKB/Swiss-Prot for CPB1 Gene

Publications for CPB1 Gene

  1. Isolation of a cDNA encoding a human serum marker for acute pancreatitis. Identification of pancreas-specific protein as pancreatic procarboxypeptidase B. (PMID: 1370825) Yamamoto K.K. … French C.K. (J. Biol. Chem. 1992) 3 4 23
  2. Comparative analysis of the sequences and three-dimensional models of human procarboxypeptidases A1, A2 and B. (PMID: 9524066) Aloy P. … Aviles F.X. (Biol. Chem. 1998) 3 4 23
  3. Purification and properties of five different forms of human procarboxypeptidases. (PMID: 2920728) Pascual R. … Aviles F.X. (Eur. J. Biochem. 1989) 3 4
  4. Human procarboxypeptidase B: three-dimensional structure and implications for thrombin-activatable fibrinolysis inhibitor (TAFI). (PMID: 12162965) Barbosa-Pereira P.J. … Vendrell J. (J. Mol. Biol. 2002) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CPB1 Gene

Sources for CPB1 Gene

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