 |
 | Services
| |
 |
Aliases & Descriptions for CPAMD8
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ42058 2 | | FLJ90618 2 | | K-CAP 1, 2 | | KIAA1283 1, 2, 3 | | VIP 1, 2 |
| | | Descriptions |
|---|
| C3 and PZP-like, alpha-2-macroglobulin domain containing 8 2 | | alpha-2 macroglobulin family protein VIP 2 |
|
| | Search outside databases for aliases for CPAMD8 genePrevious GC identifer: GC19M016866 |
Summaries for CPAMD8(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for CPAMD8: CPAMD8 belongs to the complement component-3 (C3; MIM 120700)/alpha-2-macroglobulin (A2M; MIM 103950) family of proteins, which are involved in innate immunity and damage control. Complement components recognize and eliminate pathogens by direct binding or by mediating opsonization/phagocytosis and intracellular killing, and A2M is a broad-spectrum protease inhibitor (Li et al., 2004 [PubMed 15177561]).[supplied by OMIM]
|
Genomic Location for CPAMD8
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.12CPAMD8 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M016867:
(about GC identifiers)
Start:
|
16,864,762 bp from pter |
End:
|
16,998,625 bp from pter |
Size:
|
133,864 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011295.10
| Proteins for CPAMD8
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: CPMD8_HUMAN, Q8IZJ3 (See
protein sequence)Recommended Name: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 precursor Size: 1885 amino acids; 206656 Da
Subunit: Interacts with heparin
Subcellular location: Secreted (Potential). Membrane. Note=Plasma membrane-associated
Secondary accessions: Q8NC09 Q9ULD7Alternative splicing: 2 isoforms: Q8IZJ3-1 Q8IZJ3-2 Post-translational modifications:
Appears to be proteolytically cleaved into two chains of about 70 and 130 kDa1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_056507.2
ENSEMBL proteins: ENSP00000291440 ENSP00000373577
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for CPAMD8: Assays for CPAMD8: | Protein
Domains/ Families for CPAMD8(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8IZJ3
ProtoNet protein and cluster: Q8IZJ3 3 Blocks protein families: IPB001599 Alpha-2-macroglobulin IPB002890 Alpha-2-macroglobulin IPB009048 Alpha-macroglobulin
UniProtKB/Swiss-Prot: CPMD8_HUMAN, Q8IZJ3Similarity: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) familySimilarity: Contains 1 Kazal-like domain | Gene Function for CPAMD8
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015692
Applied Biosystems Silencer® siRNAs for CPAMD8
Sigma-Aldrich siRNA for CPAMD8  Sigma-Aldrich shRNA for CPAMD8  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015692                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015692                                  untagged cDNA clones in CMV expression vector (see all 2): NM_015692 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_015692
UniProtKB/Swiss-Prot: CPMD8_HUMAN, Q8IZJ3Induction: Up-regulated by interleukin-1beta (IL-1beta) and 6 (IL-6)2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004867 | serine-type endopeptidase inhibitor activity |
IEA | -- | | GO:0005515 | protein binding |
IEA | -- | About this table | Pathways & Interactions for CPAMD8
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| -- |
Drugs & Compounds for CPAMD8(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for CPAMD8
|
Transcripts for CPAMD8(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015692
Sigma-Aldrich siRNA for CPAMD8  Sigma-Aldrich shRNA for CPAMD8  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_015692 REFSEQ mRNAs for CPAMD8 gene: NM_015692.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_015692               OriGene GFP tagged cDNA clone in CMV expression vector: NM_015692                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015692                                  untagged cDNA clones in CMV expression vector (see all 2): NM_015692  Additional cDNA sequence: AB033109.1 AK075099.1 AK092632.1 AY101765.1 BC067854.1 8 DOTS entries: DT.99950234 DT.100025239 DT.106740 DT.100025235 DT.100772000 DT.97784875 DT.100025233 DT.121477977 24/86 AceView cDNA sequences (see all 86
):AK124052 BF724694 CD243466 CA388683 BF726092 CA392927 CA388956 AI683732 CA388955 BF724846 CD244746 BM720454 BM723750 CA391121 CA392885 AI743501 AW130835 C00518 BF724845 NM_015692 BU739909 AI636733 CA396202 CA442525
highest scoring ESTs for CPAMD8:AI076780 AI636733 AW118028 AW172400 BC067854 BF724694 BF726092 BF848026 CA388683 CA388956 Unigene Cluster for CPAMD8: C3 and PZP-like, alpha-2-macroglobulin domain containing 8 Hs.631644 [show with all ESTs]Unigene Representative Sequence: NM_015692
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000291440
ENST00000388925
|
Expression for CPAMD8
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| CPAMD8 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for CPAMD8
1 / 2 / 3 3 probe-sets matching CPAMD8 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CAGTTGTGGG
SOURCE GeneReport for Unigene cluster: Hs.631644
Expression variation in blood from EXPOLDB for CPAMD8 UniProtKB/Swiss-Prot: CPMD8_HUMAN, Q8IZJ3Tissue specificity: Highly expressed in the kidney, brain and testis and to a lower extent in heart, liver and small intestine |
Orthologs for CPAMD8
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CPAMD8 gene from 5/6 species (see all 6
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
CPAMD81 |
-- |
C3 and PZP-like, alpha-2-macroglobulin domain containing more |
86.32(n) 86.48(a) |
484845 XM_847618.1 XP_852711.1 |
chimpanzee (Pan troglodytes) |
CPAMD81 |
-- |
C3 and PZP-like, alpha-2-macroglobulin domain containing more |
96.74(n) 95.73(a) |
472291 XM_527666.2 XP_527666.2 |
cow (Bos taurus) |
CPAMD81 |
-- |
C3 and PZP-like, alpha-2-macroglobulin domain containing more |
85.35(n) 85.67(a) |
531032 XM_609516.3 XP_609516.2 |
mouse (Mus musculus) |
Cpamd85 |
6 |
C3 and PZP-like, alpha-2-macroglobulin domain containing more |
-- |
M65238 |
zebrafish (Danio rerio) |
LOC5641821 |
-- |
similar to C3 and PZP-like alpha-2-macroglobulin domain-containing more |
65.2(n) 65.2(a) |
564182 XM_001919455.1 XP_001919490.1 |
About this table Species with no ortholog for CPAMD8
ENSEMBL Gene Tree for CPAMD8 | Paralogs for CPAMD8(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for CPAMD8 gene
- C52 tcag7.8932
|
SNPs/Variants for CPAMD8(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for CPAMD8 (up to first 250kb)
|
Disorders & Mutations for CPAMD8
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 608841
|
Medical News for CPAMD8(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for CPAMD8 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 8 PubMed articles for CPAMD8 gene: |
Search for CPAMD8
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing CPAMD8
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing CPAMD8
(According to HUGE)
About This Section
| |
Specialized Databases showing CPAMD8(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for CPAMD8(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for CPAMD8:

 | |
 | | | | |
|
 |  |  |
| | | | Search Tocris compounds for CPAMD8 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|