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Aliases for CPAMD8 Gene

Aliases for CPAMD8 Gene

  • C3 And PZP-Like, Alpha-2-Macroglobulin Domain Containing 8 2 3
  • KIAA1283 4 6
  • C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 8 3
  • Alpha-2 Macroglobulin Family Protein VIP 3
  • K-CAP 3
  • VIP 3

External Ids for CPAMD8 Gene

Previous GeneCards Identifiers for CPAMD8 Gene

  • GC19M016866
  • GC19M016867
  • GC19M017003
  • GC07P009820

Summaries for CPAMD8 Gene

Entrez Gene Summary for CPAMD8 Gene

  • CPAMD8 belongs to the complement component-3 (C3; MIM 120700)/alpha-2-macroglobulin (A2M; MIM 103950) family of proteins, which are involved in innate immunity and damage control. Complement components recognize and eliminate pathogens by direct binding or by mediating opsonization/phagocytosis and intracellular killing, and A2M is a broad-spectrum protease inhibitor (Li et al., 2004 [PubMed 15177561]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CPAMD8 Gene

CPAMD8 (C3 And PZP-Like, Alpha-2-Macroglobulin Domain Containing 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is CD109.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPAMD8 Gene

Genomics for CPAMD8 Gene

Genomic Location for CPAMD8 Gene

16,892,947 bp from pter
17,026,815 bp from pter
133,869 bases
Minus strand

Genomic View for CPAMD8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPAMD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPAMD8 Gene

No data available for Regulatory Elements for CPAMD8 Gene

Proteins for CPAMD8 Gene

  • Protein details for CPAMD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • Q8NC09
    • Q9ULD7

    Protein attributes for CPAMD8 Gene

    1885 amino acids
    Molecular mass:
    206702 Da
    Quaternary structure:
    • Interacts with heparin.
    • Sequence=BAC11400.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CPAMD8 Gene


neXtProt entry for CPAMD8 Gene

Proteomics data for CPAMD8 Gene at MOPED

Post-translational modifications for CPAMD8 Gene

  • Proteolytically cleaved into 2 chains of about 70 and 130 kDa. The fragments are not connected by disulfide bonds.
  • Glycosylation at Asn117, Asn190, Asn267, Asn757, and Asn1439
  • Modification sites at PhosphoSitePlus

Other Protein References for CPAMD8 Gene

No data available for DME Specific Peptides for CPAMD8 Gene

Domains for CPAMD8 Gene

Suggested Antigen Peptide Sequences for CPAMD8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Kazal-like domain.
  • Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
  • Contains 1 Kazal-like domain.
  • Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
genes like me logo Genes that share domains with CPAMD8: view

No data available for Gene Families for CPAMD8 Gene

Function for CPAMD8 Gene

Molecular function for CPAMD8 Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated by IL1B/interleukin-1 beta and IL6/interleukin-6.

Gene Ontology (GO) - Molecular Function for CPAMD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004866 endopeptidase inhibitor activity --
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CPAMD8: view

Animal Model Products

CRISPR Products

miRNA for CPAMD8 Gene

miRTarBase miRNAs that target CPAMD8

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPAMD8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for CPAMD8 Gene

Localization for CPAMD8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPAMD8 Gene

Secreted. Cell membrane; Peripheral membrane protein; Extracellular side.

Subcellular locations from

Jensen Localization Image for CPAMD8 Gene COMPARTMENTS Subcellular localization image for CPAMD8 gene
Compartment Confidence
plasma membrane 5
extracellular 4
nucleus 1

Gene Ontology (GO) - Cellular Components for CPAMD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with CPAMD8: view

Pathways for CPAMD8 Gene

genes like me logo Genes that share pathways with CPAMD8: view

Pathways by source for CPAMD8 Gene

Interacting Proteins for CPAMD8 Gene

Gene Ontology (GO) - Biological Process for CPAMD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with CPAMD8: view

Transcripts for CPAMD8 Gene

Unigene Clusters for CPAMD8 Gene

C3 and PZP-like, alpha-2-macroglobulin domain containing 8:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPAMD8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPAMD8 Gene

No ASD Table

Relevant External Links for CPAMD8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPAMD8 Gene

mRNA expression in normal human tissues for CPAMD8 Gene

mRNA differential expression in normal tissues according to GTEx for CPAMD8 Gene

This gene is overexpressed in Prostate (6.8).

Protein differential expression in normal tissues for CPAMD8 Gene

This gene is overexpressed in Vitreous humor (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CPAMD8 Gene

SOURCE GeneReport for Unigene cluster for CPAMD8 Gene Hs.631644

mRNA Expression by UniProt/SwissProt for CPAMD8 Gene

Tissue specificity: Highly expressed in the kidney, brain and testis and to a lower extent in heart, liver and small intestine.
genes like me logo Genes that share expressions with CPAMD8: view

Expression partners for CPAMD8 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CPAMD8 Gene

Orthologs for CPAMD8 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPAMD8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CPAMD8 35
  • 85.49 (n)
  • 85.69 (a)
  • 86 (a)
(Canis familiaris)
Mammalia CPAMD8 35
  • 85.57 (n)
  • 85.5 (a)
  • 85 (a)
(Pan troglodytes)
Mammalia LOC455828 35
  • 96.5 (n)
  • 95.75 (a)
(Monodelphis domestica)
Mammalia CPAMD8 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia CPAMD8 36
  • 66 (a)
(Gallus gallus)
Aves CPAMD8 35
  • 70.05 (n)
  • 71.27 (a)
  • 67 (a)
(Anolis carolinensis)
Reptilia CPAMD8 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cpamd8 35
  • 64.08 (n)
  • 65.73 (a)
(Danio rerio)
Actinopterygii cpamd8 35
  • 65.67 (n)
  • 66.13 (a)
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mcr 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for CPAMD8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CPAMD8 Gene

Gene Tree for CPAMD8 (if available)
Gene Tree for CPAMD8 (if available)

Paralogs for CPAMD8 Gene

Paralogs for CPAMD8 Gene

(5) SIMAP similar genes for CPAMD8 Gene using alignment to 6 proteins: Pseudogenes for CPAMD8 Gene

genes like me logo Genes that share paralogs with CPAMD8: view

Variants for CPAMD8 Gene

Sequence variations from dbSNP and Humsavar for CPAMD8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs706761 - 16,914,482(+) GGACA(A/G)TGCCG reference, missense
rs706765 -- 16,903,109(-) CCCTA(A/G)ACTCA intron-variant
rs734567 -- 16,904,797(-) GGGTA(A/G)GGTTG intron-variant
rs734568 -- 16,904,875(-) GTCAG(A/G)AGGGA intron-variant
rs773853 -- 16,909,878(-) tgaga(C/T)tgttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPAMD8 Gene

Variant ID Type Subtype PubMed ID
nsv911168 CNV Loss 21882294
nsv911169 CNV Loss 21882294
nsv911170 CNV Loss 21882294
dgv3755n71 CNV Loss 21882294
nsv911172 CNV Loss 21882294
nsv911174 CNV Loss 21882294
esv29414 CNV Loss 19812545
esv2718270 CNV Deletion 23290073
nsv911175 CNV Loss 21882294
esv2669422 CNV Deletion 23128226
esv2675257 CNV Deletion 23128226
nsv2426 CNV Insertion 18451855
esv1011304 CNV Loss 20482838
nsv519740 CNV Gain+Loss 19592680
esv2718271 CNV Deletion 23290073
esv32733 CNV Gain 17666407

Relevant External Links for CPAMD8 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPAMD8 Gene

Disorders for CPAMD8 Gene

Relevant External Links for CPAMD8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for CPAMD8 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CPAMD8 Gene

Publications for CPAMD8 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Identification and characterization of CPAMD8, a novel member of the complement 3/alpha2-macroglobulin family with a C-terminal Kazal domain. (PMID: 15177561) Li Z.-F. … Engvall E. (Genomics 2004) 3 4
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PMID: 19010793) Baranzini S.E. … Oksenberg J.R. (Hum. Mol. Genet. 2009) 3 48

Products for CPAMD8 Gene

Sources for CPAMD8 Gene

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