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Aliases for CPAMD8 Gene

Aliases for CPAMD8 Gene

  • C3 And PZP Like, Alpha-2-Macroglobulin Domain Containing 8 2 3 5
  • C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 8 3
  • Alpha-2 Macroglobulin Family Protein VIP 3
  • KIAA1283 4
  • K-CAP 3
  • VIP 3

External Ids for CPAMD8 Gene

Previous GeneCards Identifiers for CPAMD8 Gene

  • GC19M016866
  • GC19M016867
  • GC19M017003
  • GC07P009820

Summaries for CPAMD8 Gene

Entrez Gene Summary for CPAMD8 Gene

  • CPAMD8 belongs to the complement component-3 (C3; MIM 120700)/alpha-2-macroglobulin (A2M; MIM 103950) family of proteins, which are involved in innate immunity and damage control. Complement components recognize and eliminate pathogens by direct binding or by mediating opsonization/phagocytosis and intracellular killing, and A2M is a broad-spectrum protease inhibitor (Li et al., 2004 [PubMed 15177561]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CPAMD8 Gene

CPAMD8 (C3 And PZP Like, Alpha-2-Macroglobulin Domain Containing 8) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and endopeptidase inhibitor activity. An important paralog of this gene is CD109.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPAMD8 Gene

Genomics for CPAMD8 Gene

Regulatory Elements for CPAMD8 Gene

Enhancers for CPAMD8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F016956 1.1 Ensembl ENCODE 26.9 +69.7 69722 1.8 PKNOX1 FEZF1 ZBTB40 RAD21 ZNF366 ZNF143 ZNF207 THAP11 ZNF654 REST CPAMD8 ENSG00000269578 MVB12A ENSG00000268087 COLGALT1 ENSG00000267904 PLVAP RAB8A ENSG00000268743 GC19P019224
GH19F016961 0.7 ENCODE 27.3 +65.2 65190 0.9 GATAD2A KLF1 PKNOX1 CREB3L1 FOXA3 KLF17 ZIC2 ZNF2 ZFP69B ZNF692 CPAMD8 GC19P019224 GC19P019208
GH19F017072 1.6 FANTOM5 ENCODE 11.2 -50.4 -50437 8.6 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ENSG00000268743 MYO9B SIN3B ENSG00000269578 ENSG00000267904 HAUS8 ENSG00000268087 PLVAP CPAMD8 ANO8
GH19F016819 1.2 Ensembl ENCODE 11.3 +203.6 203638 6.5 ATF1 GLIS2 FOS SP3 YY2 ZNF518A SREBF1 SMARCA4 PBX2 GLIS1 ENSG00000269578 MVB12A ENSG00000268087 COLGALT1 CPAMD8 ENSG00000267904 PLVAP RAB8A ENSG00000268743 SIN3B
GH19F017239 1.2 ENCODE 10.5 -218.2 -218199 10.4 HDGF PKNOX1 CREB3L1 ARNT MLX ARID4B SIN3A DMAP1 ZNF2 YY1 MVB12A NR2F6 ENSG00000267904 ENSG00000268087 OCEL1 ENSG00000269578 ANO8 BST2 CPAMD8 RPL18A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CPAMD8 on UCSC Golden Path with GeneCards custom track

Promoters for CPAMD8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CPAMD8 Gene

16,892,947 bp from pter
17,026,818 bp from pter
133,872 bases
Minus strand

Genomic View for CPAMD8 Gene

Genes around CPAMD8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPAMD8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPAMD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPAMD8 Gene

Proteins for CPAMD8 Gene

  • Protein details for CPAMD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • Q8NC09
    • Q9ULD7

    Protein attributes for CPAMD8 Gene

    1885 amino acids
    Molecular mass:
    206702 Da
    Quaternary structure:
    • Interacts with heparin.
    • Sequence=BAC11400.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CPAMD8 Gene


neXtProt entry for CPAMD8 Gene

Post-translational modifications for CPAMD8 Gene

  • Proteolytically cleaved into 2 chains of about 70 and 130 kDa. The fragments are not connected by disulfide bonds.
  • Glycosylation at Asn 117, Asn 190, Asn 267, Asn 757, and Asn 1439
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CPAMD8 Gene

Domains & Families for CPAMD8 Gene

Suggested Antigen Peptide Sequences for CPAMD8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Kazal-like domain.
  • Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
  • Contains 1 Kazal-like domain.
  • Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
genes like me logo Genes that share domains with CPAMD8: view

Function for CPAMD8 Gene

Molecular function for CPAMD8 Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated by IL1B/interleukin-1 beta and IL6/interleukin-6.

Gene Ontology (GO) - Molecular Function for CPAMD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with CPAMD8: view
genes like me logo Genes that share phenotypes with CPAMD8: view

Animal Model Products

miRNA for CPAMD8 Gene

miRTarBase miRNAs that target CPAMD8

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPAMD8 Gene

Localization for CPAMD8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPAMD8 Gene

Secreted. Cell membrane; Peripheral membrane protein; Extracellular side.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPAMD8 gene
Compartment Confidence
plasma membrane 4
extracellular 2

Gene Ontology (GO) - Cellular Components for CPAMD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CPAMD8: view

Pathways & Interactions for CPAMD8 Gene

SuperPathways for CPAMD8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CPAMD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with CPAMD8: view

No data available for Pathways by source and SIGNOR curated interactions for CPAMD8 Gene

Transcripts for CPAMD8 Gene

Unigene Clusters for CPAMD8 Gene

C3 and PZP-like, alpha-2-macroglobulin domain containing 8:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPAMD8 Gene

No ASD Table

Relevant External Links for CPAMD8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPAMD8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CPAMD8 Gene

mRNA differential expression in normal tissues according to GTEx for CPAMD8 Gene

This gene is overexpressed in Prostate (x6.8).

Protein differential expression in normal tissues from HIPED for CPAMD8 Gene

This gene is overexpressed in Vitreous humor (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CPAMD8 Gene

Protein tissue co-expression partners for CPAMD8 Gene

NURSA nuclear receptor signaling pathways regulating expression of CPAMD8 Gene:


SOURCE GeneReport for Unigene cluster for CPAMD8 Gene:


mRNA Expression by UniProt/SwissProt for CPAMD8 Gene:

Tissue specificity: Highly expressed in the kidney, brain and testis and to a lower extent in heart, liver and small intestine.
genes like me logo Genes that share expression patterns with CPAMD8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CPAMD8 Gene

Orthologs for CPAMD8 Gene

This gene was present in the common ancestor of animals.

Orthologs for CPAMD8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC455828 34
  • 96.5 (n)
(Canis familiaris)
Mammalia CPAMD8 34 35
  • 85.57 (n)
(Bos Taurus)
Mammalia CPAMD8 34 35
  • 85.49 (n)
(Monodelphis domestica)
Mammalia CPAMD8 35
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia CPAMD8 35
  • 66 (a)
(Gallus gallus)
Aves CPAMD8 34 35
  • 70.05 (n)
(Anolis carolinensis)
Reptilia CPAMD8 35
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cpamd8 34
  • 64.08 (n)
(Danio rerio)
Actinopterygii cpamd8 34
  • 65.67 (n)
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mcr 35
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
Species where no ortholog for CPAMD8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CPAMD8 Gene

Gene Tree for CPAMD8 (if available)
Gene Tree for CPAMD8 (if available)

Paralogs for CPAMD8 Gene

Paralogs for CPAMD8 Gene

(5) SIMAP similar genes for CPAMD8 Gene using alignment to 6 proteins: Pseudogenes for CPAMD8 Gene

genes like me logo Genes that share paralogs with CPAMD8: view

Variants for CPAMD8 Gene

Sequence variations from dbSNP and Humsavar for CPAMD8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs869025231 Uncertain significance 16,906,964(-) GCCTG(A/G)CCATC reference, missense
rs10401666 -- 16,922,159(+) TACAC(C/T)CACAT intron-variant
rs10401721 -- 16,941,903(+) ggagg(C/T)tggag intron-variant
rs10401948 -- 17,002,205(+) AGCAG(C/T)GTGAT intron-variant
rs10402701 -- 17,020,165(+) GATGC(C/G)GTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPAMD8 Gene

Variant ID Type Subtype PubMed ID
nsv578736 CNV gain 21841781
nsv519740 CNV gain+loss 19592680
nsv472179 CNV novel sequence insertion 20440878
nsv2426 CNV insertion 18451855
nsv1148866 CNV duplication 26484159
nsv1136280 CNV deletion 24896259
nsv1118818 CNV deletion 24896259
nsv1078434 CNV duplication 25765185
esv3643807 CNV loss 21293372
esv3643806 CNV loss 21293372
esv3643805 CNV loss 21293372
esv3583265 CNV loss 25503493
esv3556112 CNV deletion 23714750
esv3556111 CNV deletion 23714750
esv3353965 CNV insertion 20981092
esv32733 CNV gain 17666407
esv29414 CNV loss 19812545
esv2718271 CNV deletion 23290073
esv2718270 CNV deletion 23290073
esv2675257 CNV deletion 23128226
esv2669422 CNV deletion 23128226
esv1011304 CNV loss 20482838
dgv1990e59 CNV duplication 20981092

Variation tolerance for CPAMD8 Gene

Residual Variation Intolerance Score: 98.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.40; 96.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPAMD8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPAMD8 Gene

Disorders for CPAMD8 Gene

Relevant External Links for CPAMD8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CPAMD8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPAMD8 Gene

Publications for CPAMD8 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PMID: 19010793) Baranzini S.E. … Oksenberg J.R. (Hum. Mol. Genet. 2009) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Identification and characterization of CPAMD8, a novel member of the complement 3/alpha2-macroglobulin family with a C-terminal Kazal domain. (PMID: 15177561) Li Z.-F. … Engvall E. (Genomics 2004) 3 4 64

Products for CPAMD8 Gene

Sources for CPAMD8 Gene

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