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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CPA6 Gene

protein-coding GIFtS: 52
GCID: GC08M068384

carboxypeptidase A6

Explore 24 diseases affiliated with
CPA6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Carboxypeptidase A6¹ ²		FEB11²
CPAH¹ ² ³		EC 3.4.17.1³
Carboxypeptidase B² ³		EC 3.4.17⁸
ETL5²

External Ids:	HGNC: 17245¹	Entrez Gene: 57094²	Ensembl: ENSG00000165078⁷	OMIM: 609562⁵	UniProtKB: Q8N4T0³

Export aliases for CPA6 gene to outside databases

Previous GC identifers: GC08M067463 GC08M068273 GC08M068057 GC08M068496 GC08M063826

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CPA6:

The protein encoded by this gene belongs to the family of carboxypeptidases, which catalyze the release of C-terminal

amino acid, and have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides.

Polymorphic variants and a reciprocal translocation t(6;8)(q26;q13) involving this gene, have been associated with

Duane retraction syndrome.(provided by RefSeq, Sep 2010)

UniProtKB/Swiss-Prot: CBPA6_HUMAN, Q8N4T0

Function: May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May

convert inactive angiotensin I into the biologically active angiotensin II

Gene Wiki entry for CPA6 (Carboxypeptidase A6)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008183.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CPA6 gene promoter:
TBP STAT1 FOXD3 STAT1beta STAT1alpha HSF2 FOXJ2 (long isoform) STAT3 Cart-1 FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CPA6 promoter sequence

Search SABiosciences Chromatin IP Primers for CPA6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPA6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13.2 Ensembl cytogenetic band: 8q13.2 HGNC cytogenetic band: 8q12.3

CPA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPA6 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M068384: view genomic region (about GC identifiers)

Start:	68,334,360 bp from pter	End:	68,658,620 bp from pter
Size:	324,261 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CBPA6_HUMAN, Q8N4T0 (See protein sequence)

Recommended Name: Carboxypeptidase A6 precursor

Size: 437 amino acids; 51008 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Subcellular location: Secreted, extracellular space, extracellular matrix

Secondary accessions: Q8NEX8 Q8TDE8 Q9NRI9

Alternative splicing: 3 isoforms: Q8N4T0-1 Q8N4T0-2 Q8N4T0-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CPA6: NX_Q8N4T0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N4T0

4 DME Specific Peptides for CPA6 (Q8N4T0)

FELRDTG

PESEPEV

AFCQWFV

GIHAREW

CPA6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_065094.3

ENSEMBL proteins:

ENSP00000419016 ENSP00000297770 ENSP00000431112 ENSP00000297769

Human Recombinant Protein Products for CPA6:

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	Uscn Proteins for CPA6

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	IEA	--

CPA6 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CPA6 for domains About GeneDecksing

3 InterPro domains/families:

IPR003146 Prot_inh_M14A

IPR000834 Peptidase_M14

IPR009020 Prot_inh_propept

Graphical View of Domain Structure for InterPro Entry Q8N4T0

ProtoNet protein and cluster: Q8N4T0

2 Blocks protein families:

IPB000834 Zinc carboxypeptidase A metalloprotease (M14)

IPB003146 Carboxypeptidase activation peptide

UniProtKB/Swiss-Prot: CBPA6_HUMAN, Q8N4T0

Similarity: Belongs to the peptidase M14 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CBPA6_HUMAN, Q8N4T0

Function: May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May

convert inactive angiotensin I into the biologically active angiotensin II

Catalytic activity: Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro

Enzyme Numbers (IUBMB): EC 3.4.17² EC 3.4.17.1¹

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004181	metallocarboxypeptidase activity	NAS	11836249
GO:0008270	zinc ion binding	IEA	--

CPA6 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CPA6

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		hsa-miR-526b hsa-miR-570
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPA6

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CPA6

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--

CPA6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CPA6 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CPA6

5 HMDB Compounds for CPA6 About this table

Compound	Synonyms	CAS #	PubMed Ids
Kinetensin	Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu	103131-69-7	--
Kinetensin 1-8	Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe;KT(1-8)	51833-69-3	--
Neuromedin N	Ile-Pro-Tyr-Ile-Leu;NN	102577-25-3	--
Neuromedin N (1-4)	Ile-Pro-Tyr-Ile	--	--
Zinc	Zinc (see all 2)	7440-66-6	--

10/11 Novoseek chemical compound relationships for CPA6 gene (see all 11) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
epsilon aminocaproic acid	78.6	8	8112348 (1), 17606760 (1), 9102401 (1), 1677272 (1) (see all 7)
deae-sephadex a-25	74.6	1	8765230 (1)
lysine	70.3	23	8112348 (2), 11071275 (1), 11442827 (1), 15737740 (1) (see all 16)
trypsinogen	64.5	7	11167870 (2), 16437625 (2), 15211118 (2), 15850341 (1)
c-peptide	44.9	6	1414126 (1), 8862001 (1), 14614535 (1), 16894482 (1)
fibrinogen	32.6	1	11012092 (1)
pcbs	30.2	3	1370825 (1), 8322019 (1)
arginine	28.8	8	8244278 (1), 2096887 (1), 1952934 (1), 8428004 (1) (see all 6)
agarose	10.9	2	9058653 (1), 10885198 (1)
cysteine	0.887	1	10861591 (1)

Search CenterWatch for drugs/clinical trials and news about CPA6 / CBPA6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CPA6 gene (2 alternative transcripts):

NM_020361.4 NM_001127445.1

Unigene Cluster for CPA6:

Carboxypeptidase A6

Hs.658850 [show with all ESTs]

Unigene Representative Sequence: NM_020361

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000479862 ENST00000297770(uc003xxq.4) ENST00000518549(uc003xxs.2)

ENST00000297769(uc003xxr.4)

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		hsa-miR-526b hsa-miR-570
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPA6

Additional cDNA sequence:

AF221594.1 AY044833.1 BC033684.1

3 DOTS entries:

DT.206265 DT.100695623 DT.206266

9 AceView cDNA sequences:

BK000188 AF221594 NM_020361 BI756197 H86480 BC033684 BF445564 H84399

BI758481

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for CPA6 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11a	·	11b
SP1:																	-
SP2:
SP3:					-												-		-		-

ECgene alternative splicing isoforms for CPA6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CPA6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCTCAATTA

About this image

CPA6 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Zeugopod Epiphyseal End

Chondrocytes

Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CPA6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CPA6

SOURCE GeneReport for Unigene cluster: Hs.658850

UniProtKB/Swiss-Prot: CBPA6_HUMAN, Q8N4T0

Tissue specificity: Expressed in the hippocampus, nucleus raphe, and cortex

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CPA6 gene from 7/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cpa6^{1 , 5}	carboxypeptidase A6^{1, 5}	86.35(n)¹ 84.44(a)¹		1 (2.45 cM)⁵ 329093¹ NM_177834.3¹ NP_808502.2¹ 10324720⁵
chicken (Gallus gallus)	Aves	CPA6¹	carboxypeptidase A6	77.81(n) 82.58(a)		420171 NM_001006344.1 NP_001006344.1
lizard (Anolis carolinensis)	Reptilia	CPA6⁶	--	79(a)	1 ↔ 1	4(31271222-31313396)
African clawed frog (Xenopus laevis)	Amphibia	cpa6-prov²	carboxypeptidase A6	75.95(n)		BC041315.1
zebrafish (Danio rerio)	Actinopterygii	LOC100002342¹	carboxypeptidase A6-like	67.16(n) 69.29(a)		100002342 XM_001342113.4 XP_001342149.4
fruit fly (Drosophila melanogaster)	Insecta	CG3097¹	CG3097	43.05(n) 35.57(a)		31503 NM_132031.2 NP_572259.1
worm (Caenorhabditis elegans)	Secernentea	Y18H1A.9⁶ Y59C2A.1⁶ (see all 9)	Protein Y59C2A.1 (see all 9)	28(a) 28(a) (see all 9)	possible ortholog possible ortholog (see all 9)	I(748231-757013) II(2208117-2212868)

ENSEMBL Gene Tree for CPA6 (if available)
TreeFam Gene Tree for CPA6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CPA6 gene

CPA3² CPB2² CPA4² CPA2² CPO² CPA1² CPB1² CPA5²

9 SIMAP similar genes for CPA6 using alignment to 2 protein entries: CBPA6_HUMAN (see all proteins):

DKFZp779K1333 CPA3 CPB1 CPO CPA4 CPA2

CPA1 CPB2 CPA5

CPA6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs77633499^1,2	C	--	63826008(+)	`ATGTTG/TCTCTA`	1	--	ds500¹		2		WA	120
rs56364242^1,2	C,F	--	63826146(+)	`CAGCTC/TACTGC`	1	--	ds500¹		3		WA CSA	6
rs28641561^1,2		--	63826229(+)	`CACCAC/TGCCCA`	1	--	ds500¹		1		NA	2
rs3395^1,2	C,F,O,H	--	63826472(+)	`CCTAAT/CTGAGG`	1	--	ut3¹ ese³		15		MN NA NS EA	1604
rs112875997^1,2	C,F	--	63826917(+)	`TCACGT/CAGTTC`	2	/L	syn¹		2		CSA NA	4552
rs10091944^1,2	C,F	--	63827070(+)	`GTATCC/TGCTTA`	1	--	int¹		6		NA WA CSA	128
rs79526414^1,2	F	--	63827150(+)	`ATCTGG/CTGCAT`	1	--	int¹		1		WA	118
rs79940194^1,2	F	--	63827725(+)	`CACTCC/TGGCTT`	1	--	int¹		1		WA	118
rs73691986^1,2	C	--	63828108(+)	`CTAGAT/CCAGGG`	1	--	int¹		2		WA	120
rs11776412^1,2	C,H	--	63828424(+)	`tgtctC/Tccatc`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CPA6 (68334360 - 68584360 bp, first 250kb of CPA6)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 12 variations for CPA6
10 CNVs: 1204 8607 82638 38724 95488 33045 8606 95487 65158 95489
2 Indels: 95491 95490
Human Gene Mutation Database (HGMD): CPA6

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CPA6

DNA2.0 Custom Variant and Variant Library Synthesis for CPA6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CPA6 for disorders About GeneDecksing

OMIM gene information: 609562 OMIM disorders: --

UniProtKB/Swiss-Prot: CBPA6_HUMAN, Q8N4T0

Note=A chromosomal aberration involving CPA6 was found in a patient with Duane retraction syndrome.

Translocation t(6;8)(q26;q13)

Defects in CPA6 are the cause of epilepsy, familial temporal lobe, type 5 (ETL5) [MIM:614417]. ETL5 is a focal

form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe. Seizures are

usually accompanied by sensory symptoms, most often auditory in nature

Defects in CPA6 are the cause of familial febrile convulsions type 11 (FEB11) [MIM:614418]. FEB11 consists of

seizures associated with febrile episodes in childhood without any evidence of intracranial infection or defined

pathologic or traumatic cause. It is a common condition, affecting 2-5% of children aged 3 months to 5 years. The

majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less

than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or

more than one seizure in a 24 hour period. The likelihood of developing epilepsy following simple febrile seizures is

low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy

20/24 diseases for CPA6 (see all 24): About MalaCards

duane retraction syndrome tricuspid valve insufficiency temporal lobe epilepsy cluster headache

febrile seizures generalized epilepsy systemic lupus erythematosus lupus erythematosus

headache acute pancreatitis convulsions alzheimer's disease

seizures rheumatoid arthritis leishmaniasis hepatitis b

hermaphroditism pancreatitis arthritis pharyngitis

1 disease from the University of Copenhagen DISEASES database for CPA6:

Acute pancreatitis

3 Novoseek disease relationships for CPA6 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
acute pancreatitis	54.2	11	16437625 (2), 15211118 (2), 18849642 (1), 9505893 (1) (see all 8)
pancreatitis	9.81	1	15850341 (1)
alzheimers disease	0	1	12705322 (1)

Human Genome Epidemiology (HuGE) Navigator: CPA6 (144 documents)

Export disorders for CPA6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CPA6 gene, integrated from 9 sources (see all 130):
(articles sorted by number of sources associating them with CPA6)

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Identification and characterization of three members of the human metallocarboxypeptidase gene family. (PubMed id 11836249)^{1, 2, 3} Wei S.... Fricker L.D. (2002)
Characterization of carboxypeptidase A6, an extracellular matrix peptidase. (PubMed id 18178555)^{1, 2, 9} Lyons P.J....Fricker L.D. (2008)
A peptidase gene in chromosome 8q is disrupted by a balanced translocation in a duane syndrome patient. (PubMed id 12454025)^{1, 2, 9} Pizzuti A.... Dallapiccola B. (2002)
Carboxypeptidase A6 gene (CPA6) mutations in a recessive familial form of febrile seizures and temporal lobe epilepsy and in sporadic temporal lobe epilepsy. (PubMed id 21922598)^{1, 2} Salzmann A.... Malafosse A. (2011)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Naturally occurring carboxypeptidase A6 mutations: eff ect on enzyme function and association with epilepsy. (PubMed id 23105115)¹ Sapio M.R....Fricker L.D. (2012)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
Substrate specificity of human carboxypeptidase A6. (PubMed id 20855895)¹ Lyons P.J. and Fricker L.D. (2010)
Thrombin-activatable carboxypeptidase B cleavage of o steopontin regulates neutrophil survival and synoviocyte binding in rheumatoid arthritis. (PubMed id 19790060)¹ Sharif S.A....Leung L.L. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57094	HGNC: 17245	AceView: CPA6	Ensembl:ENSG00000165078	euGenes: HUgn57094
ECgene: CPA6	H-InvDB: CPA6

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CPA6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CPA6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CPA6 gene:
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carboxypeptidase A6

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