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Aliases for CPA5 Gene

Aliases for CPA5 Gene

  • Carboxypeptidase A5 2 3
  • EC 3.4.17.1 63
  • EC 3.4.17.- 4
  • EC 3.4.17 63

External Ids for CPA5 Gene

Summaries for CPA5 Gene

Entrez Gene Summary for CPA5 Gene

  • Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002 [PubMed 11836249]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CPA5 Gene

CPA5 (Carboxypeptidase A5) is a Protein Coding gene. GO annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPA3.

Gene Wiki entry for CPA5 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPA5 Gene

Genomics for CPA5 Gene

Genomic Location for CPA5 Gene

Start:
130,344,790 bp from pter
End:
130,368,730 bp from pter
Size:
23,941 bases
Orientation:
Plus strand

Genomic View for CPA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPA5 Gene

Regulatory Elements for CPA5 Gene

Proteins for CPA5 Gene

  • Protein details for CPA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXQ8-CBPA5_HUMAN
    Recommended name:
    Carboxypeptidase A5
    Protein Accession:
    Q8WXQ8
    Secondary Accessions:
    • G3V0G8
    • Q6ZNI6
    • Q86SE2
    • Q86XM3
    • Q8NA08

    Protein attributes for CPA5 Gene

    Size:
    436 amino acids
    Molecular mass:
    49036 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CPA5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPA5 Gene

Proteomics data for CPA5 Gene at MOPED

Selected DME Specific Peptides for CPA5 Gene

Post-translational modifications for CPA5 Gene

No Post-translational modifications

Domains for CPA5 Gene

Gene Families for CPA5 Gene

Suggested Antigen Peptide Sequences for CPA5 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WXQ8

UniProtKB/Swiss-Prot:

CBPA5_HUMAN
Family:
  • Belongs to the peptidase M14 family.:
    • Q8WXQ8
genes like me logo Genes that share domains with CPA5: view

Function for CPA5 Gene

Enzyme Numbers (IUBMB) for CPA5 Gene

Gene Ontology (GO) - Molecular Function for CPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity --
GO:0004181 metallocarboxypeptidase activity IEA --
GO:0008233 peptidase activity --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CPA5: view

Phenotypes for CPA5 Gene

genes like me logo Genes that share phenotypes with CPA5: view

No data available for Molecular function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CPA5 Gene

Localization for CPA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPA5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPA5 Gene COMPARTMENTS Subcellular localization image for CPA5 gene
Compartment Confidence
extracellular 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CPA5: view

Pathways for CPA5 Gene

SuperPathways for CPA5 Gene

No Data Available

Interacting Proteins for CPA5 Gene

Gene Ontology (GO) - Biological Process for CPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with CPA5: view

No data available for Pathways by source for CPA5 Gene

Compounds for CPA5 Gene

(5) HMDB Compounds for CPA5 Gene

Compound Synonyms Cas Number PubMed IDs
Kinetensin
  • Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu
103131-69-7
Kinetensin 1-8
  • Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe
51833-69-3
Neuromedin N
  • Ile-Pro-Tyr-Ile-Leu
102577-25-3
Neuromedin N (1-4)
  • Ile-Pro-Tyr-Ile
Not Available
Zinc
  • Zinc
7440-66-6
genes like me logo Genes that share compounds with CPA5: view

Transcripts for CPA5 Gene

Unigene Clusters for CPA5 Gene

Carboxypeptidase A5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPA5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a ·
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - - -
SP8: - -

ExUns: 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for CPA5 Gene

GeneLoc Exon Structure for
CPA5
ECgene alternative splicing isoforms for
CPA5

Expression for CPA5 Gene

mRNA expression in normal human tissues for CPA5 Gene

mRNA differential expression in normal tissues according to GTEx for CPA5 Gene

This gene is overexpressed in Testis (46.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CPA5 Gene

SOURCE GeneReport for Unigene cluster for CPA5 Gene Hs.567642

mRNA Expression by UniProt/SwissProt for CPA5 Gene

Q8WXQ8-CBPA5_HUMAN
Tissue specificity: Expression is very low or not detectable
genes like me logo Genes that share expressions with CPA5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CPA5 Gene

Orthologs for CPA5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CPA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPA5 35
  • 99.08 (n)
  • 99.08 (a)
CPA5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPA5 35
  • 87.57 (n)
  • 85.84 (a)
CPA5 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPA5 35
  • 89.76 (n)
  • 87.61 (a)
CPA5 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpa5 35
  • 84.24 (n)
  • 84.8 (a)
Cpa5 16
Cpa5 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPA5 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPA5 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpa5 35
  • 82.98 (n)
  • 83.85 (a)
chicken
(Gallus gallus)
Aves CPA5 35
  • 66.11 (n)
  • 60.05 (a)
CPA5 36
  • 60 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia CPA5 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12374 36
  • 27 (a)
ManyToMany
CG14820 36
  • 32 (a)
ManyToMany
CG17633 36
  • 28 (a)
ManyToMany
CG18417 36
  • 24 (a)
ManyToMany
CG18585 36
  • 31 (a)
ManyToMany
CG2915 36
  • 27 (a)
ManyToMany
CG32379 36
  • 27 (a)
ManyToMany
CG4017 36
  • 31 (a)
ManyToMany
CG4408 36
  • 26 (a)
ManyToMany
CG7025 36
  • 30 (a)
ManyToMany
CG8539 36
  • 23 (a)
ManyToMany
CG8560 36
  • 26 (a)
ManyToMany
CG8562 36
  • 26 (a)
ManyToMany
CG8563 36
  • 26 (a)
ManyToMany
CG8564 36
  • 17 (a)
ManyToMany
CG3097 37
  • 33 (a)
CG8539 37
  • 26 (a)
CG3108 37
  • 35 (a)
CG18585 37
  • 32 (a)
CG15769 37
  • 27 (a)
CG14820 37
  • 34 (a)
CG18415 37
  • 29 (a)
CG17633 37
  • 30 (a)
CG8945 37
  • 25 (a)
CG2915 37
  • 30 (a)
CG12374 37
  • 30 (a)
CG4408 37
  • 29 (a)
CG4017 37
  • 37 (a)
CG7025 37
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea F02D8.4 36
  • 25 (a)
ManyToMany
suro-1 36
  • 19 (a)
ManyToMany
T06A4.1 36
  • 23 (a)
ManyToMany
T06A4.3 36
  • 26 (a)
ManyToMany
W01A8.6 36
  • 25 (a)
ManyToMany
Y18H1A.9 36
  • 28 (a)
ManyToMany
Y47G6A.19 36
  • 26 (a)
ManyToMany
ZC434.9 36
  • 18 (a)
ManyToMany
R11A5.7 37
  • 30 (a)
Y18H1A.9 37
  • 34 (a)
T06A4.3 37
  • 28 (a)
Y59C2A.1 37
  • 31 (a)
ZC434.9 37
  • 29 (a)
Y47G6A.19 37
  • 30 (a)
W01A8.6 37
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM14 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
CSA.11311 36
  • 36 (a)
ManyToMany
CSA.4005 36
  • 20 (a)
ManyToMany
Species with no ortholog for CPA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CPA5 Gene

ENSEMBL:
Gene Tree for CPA5 (if available)
TreeFam:
Gene Tree for CPA5 (if available)

Paralogs for CPA5 Gene

Paralogs for CPA5 Gene

Selected SIMAP similar genes for CPA5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CPA5: view

Variants for CPA5 Gene

Sequence variations from dbSNP and Humsavar for CPA5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs748812 -- 130,367,757(-) AGCAT(C/T)TCCAG intron-variant
rs888397 -- 130,351,481(+) CAGCC(C/T)CGAGT intron-variant
rs918222 -- 130,352,700(+) TTGAG(G/T)TGGGG intron-variant
rs1009905 -- 130,348,848(+) aaaac(A/T)ttaaa intron-variant
rs1532044 -- 130,344,734(+) TCCTA(C/T)TGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CPA5 Gene

Variant ID Type Subtype PubMed ID
esv23964 CNV Gain 19812545
nsv515945 CNV Gain+Loss 19592680
esv2735153 CNV Deletion 23290073

Relevant External Links for CPA5 Gene

HapMap Linkage Disequilibrium report
CPA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPA5 Gene

Disorders for CPA5 Gene

Relevant External Links for CPA5

Genetic Association Database (GAD)
CPA5
genes like me logo Genes that share disorders with CPA5: view

No data available for UniProtKB/Swiss-Prot for CPA5 Gene

Publications for CPA5 Gene

  1. Identification and characterization of three members of the human metallocarboxypeptidase gene family. (PMID: 11836249) Wei S. … Fricker L.D. (J. Biol. Chem. 2002) 2 3 4
  2. Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region. (PMID: 11920156) Bonora E. … Maestrini E. (Mol. Psychiatry 2002) 3 4
  3. The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver- Russell syndrome. (PMID: 12676894) Bentley L. … Moore G.E. (J. Med. Genet. 2003) 3 4
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CPA5 Gene

Sources for CPA5 Gene

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