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Aliases for CPA5 Gene

Aliases for CPA5 Gene

  • Carboxypeptidase A5 2 3 5
  • EC 3.4.17.1 63
  • EC 3.4.17.- 4
  • EC 3.4.17 63

External Ids for CPA5 Gene

Previous GeneCards Identifiers for CPA5 Gene

  • GC07P128462
  • GC07P129523
  • GC07P129537
  • GC07P129578
  • GC07P129772
  • GC07P129986
  • GC07P124346

Summaries for CPA5 Gene

Entrez Gene Summary for CPA5 Gene

  • Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002 [PubMed 11836249]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CPA5 Gene

CPA5 (Carboxypeptidase A5) is a Protein Coding gene. Diseases associated with CPA5 include Silver-Russell Syndrome and Amebiasis. GO annotations related to this gene include peptidase activity and carboxypeptidase activity. An important paralog of this gene is CPA3.

Gene Wiki entry for CPA5 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPA5 Gene

Genomics for CPA5 Gene

Regulatory Elements for CPA5 Gene

Enhancers for CPA5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CPA5 on UCSC Golden Path with GeneCards custom track

Genomic Location for CPA5 Gene

Chromosome:
7
Start:
130,344,790 bp from pter
End:
130,374,709 bp from pter
Size:
29,920 bases
Orientation:
Plus strand

Genomic View for CPA5 Gene

Genes around CPA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPA5 Gene

Proteins for CPA5 Gene

  • Protein details for CPA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXQ8-CBPA5_HUMAN
    Recommended name:
    Carboxypeptidase A5
    Protein Accession:
    Q8WXQ8
    Secondary Accessions:
    • G3V0G8
    • Q6ZNI6
    • Q86SE2
    • Q86XM3
    • Q8NA08

    Protein attributes for CPA5 Gene

    Size:
    436 amino acids
    Molecular mass:
    49036 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CPA5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPA5 Gene

Proteomics data for CPA5 Gene at MOPED

Selected DME Specific Peptides for CPA5 Gene

Post-translational modifications for CPA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CPA5 Gene

Gene Families for CPA5 Gene

Suggested Antigen Peptide Sequences for CPA5 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WXQ8

UniProtKB/Swiss-Prot:

CBPA5_HUMAN :
  • Belongs to the peptidase M14 family.
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPA5: view

Function for CPA5 Gene

Enzyme Numbers (IUBMB) for CPA5 Gene

Gene Ontology (GO) - Molecular Function for CPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with CPA5: view
genes like me logo Genes that share phenotypes with CPA5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CPA5

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CPA5 Gene

Localization for CPA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPA5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPA5 Gene COMPARTMENTS Subcellular localization image for CPA5 gene
Compartment Confidence
extracellular 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CPA5 Gene

Pathways & Interactions for CPA5 Gene

SuperPathways for CPA5 Gene

No Data Available

Interacting Proteins for CPA5 Gene

Gene Ontology (GO) - Biological Process for CPA5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CPA5 Gene

Drugs & Compounds for CPA5 Gene

(1) Drugs for CPA5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 2102
genes like me logo Genes that share compounds with CPA5: view

Transcripts for CPA5 Gene

Unigene Clusters for CPA5 Gene

Carboxypeptidase A5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPA5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a ·
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - - -
SP8: - -

ExUns: 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for CPA5 Gene

GeneLoc Exon Structure for
CPA5
ECgene alternative splicing isoforms for
CPA5

Expression for CPA5 Gene

mRNA expression in normal human tissues for CPA5 Gene

mRNA differential expression in normal tissues according to GTEx for CPA5 Gene

This gene is overexpressed in Testis (x46.7).

Protein differential expression in normal tissues from HIPED for CPA5 Gene

This gene is overexpressed in Pancreatic juice (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CPA5 Gene



SOURCE GeneReport for Unigene cluster for CPA5 Gene Hs.567642

mRNA Expression by UniProt/SwissProt for CPA5 Gene

Q8WXQ8-CBPA5_HUMAN
Tissue specificity: Expression is very low or not detectable.
genes like me logo Genes that share expression patterns with CPA5: view

Protein tissue co-expression partners for CPA5 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CPA5 Gene

Orthologs for CPA5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CPA5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CPA5 35
  • 87.57 (n)
  • 85.84 (a)
CPA5 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPA5 35
  • 89.76 (n)
  • 87.61 (a)
CPA5 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpa5 35
  • 84.24 (n)
  • 84.8 (a)
Cpa5 16
Cpa5 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CPA5 35
  • 99.08 (n)
  • 99.08 (a)
CPA5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpa5 35
  • 82.98 (n)
  • 83.85 (a)
oppossum
(Monodelphis domestica)
Mammalia CPA5 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPA5 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPA5 35
  • 66.11 (n)
  • 60.05 (a)
CPA5 36
  • 60 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia CPA5 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12374 37
  • 30 (a)
CG14820 37
  • 34 (a)
CG15769 37
  • 27 (a)
CG17633 37
  • 30 (a)
CG18415 37
  • 29 (a)
CG18585 37
  • 32 (a)
CG2915 37
  • 30 (a)
CG3097 37
  • 33 (a)
CG3108 37
  • 35 (a)
CG4017 37
  • 37 (a)
CG4408 37
  • 29 (a)
CG7025 37
  • 36 (a)
CG8539 37
  • 26 (a)
CG8945 37
  • 25 (a)
CG12374 36
  • 27 (a)
ManyToMany
CG14820 36
  • 32 (a)
ManyToMany
CG17633 36
  • 28 (a)
ManyToMany
CG18417 36
  • 24 (a)
ManyToMany
CG18585 36
  • 31 (a)
ManyToMany
CG2915 36
  • 27 (a)
ManyToMany
CG32379 36
  • 27 (a)
ManyToMany
CG4017 36
  • 31 (a)
ManyToMany
CG4408 36
  • 26 (a)
ManyToMany
CG7025 36
  • 30 (a)
ManyToMany
CG8539 36
  • 23 (a)
ManyToMany
CG8560 36
  • 26 (a)
ManyToMany
CG8562 36
  • 26 (a)
ManyToMany
CG8563 36
  • 26 (a)
ManyToMany
CG8564 36
  • 17 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea R11A5.7 37
  • 30 (a)
T06A4.3 37
  • 28 (a)
W01A8.6 37
  • 29 (a)
Y18H1A.9 37
  • 34 (a)
Y47G6A.19 37
  • 30 (a)
Y59C2A.1 37
  • 31 (a)
ZC434.9 37
  • 29 (a)
F02D8.4 36
  • 25 (a)
ManyToMany
suro-1 36
  • 19 (a)
ManyToMany
T06A4.1 36
  • 23 (a)
ManyToMany
T06A4.3 36
  • 26 (a)
ManyToMany
W01A8.6 36
  • 25 (a)
ManyToMany
Y18H1A.9 36
  • 28 (a)
ManyToMany
Y47G6A.19 36
  • 26 (a)
ManyToMany
ZC434.9 36
  • 18 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM14 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
CSA.11311 36
  • 36 (a)
ManyToMany
CSA.4005 36
  • 20 (a)
ManyToMany
Species with no ortholog for CPA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CPA5 Gene

ENSEMBL:
Gene Tree for CPA5 (if available)
TreeFam:
Gene Tree for CPA5 (if available)

Paralogs for CPA5 Gene

Paralogs for CPA5 Gene

(9) SIMAP similar genes for CPA5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CPA5: view

Variants for CPA5 Gene

Sequence variations from dbSNP and Humsavar for CPA5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs17388190 - 130,350,011(+) GCCTC(C/T)CTGTG nc-transcript-variant, reference, missense
VAR_017192 -
VAR_017193 -
VAR_048596 -
rs888397 -- 130,351,481(+) CAGCC(C/T)CGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPA5 Gene

Variant ID Type Subtype PubMed ID
esv23964 CNV Gain 19812545
nsv515945 CNV Gain+Loss 19592680
esv2735153 CNV Deletion 23290073

Variation tolerance for CPA5 Gene

Residual Variation Intolerance Score: 93.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.65; 89.15% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CPA5 Gene

Disorders for CPA5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CPA5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
silver-russell syndrome
  • silver russell dwarfism
amebiasis
  • amoebiasis
- elite association - COSMIC cancer census association via MalaCards
Search CPA5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CPA5

Genetic Association Database (GAD)
CPA5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPA5
genes like me logo Genes that share disorders with CPA5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPA5 Gene

Publications for CPA5 Gene

  1. Identification and characterization of three members of the human metallocarboxypeptidase gene family. (PMID: 11836249) Wei S. … Fricker L.D. (J. Biol. Chem. 2002) 2 3 4 67
  2. A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells. (PMID: 23284306) Xie L. … Green M.R. (PLoS Genet. 2012) 3
  3. Carboxypeptidase A5 identifies a novel mast cell lineage in the zebrafish providing new insight into mast cell fate determination. (PMID: 18635811) Dobson J.T. … Berman J.N. (Blood 2008) 23
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for CPA5 Gene

Sources for CPA5 Gene

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