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Aliases for CPA5 Gene

Aliases for CPA5 Gene

  • Carboxypeptidase A5 2 3 5
  • EC 61
  • EC 3.4.17.- 4
  • EC 3.4.17 61

External Ids for CPA5 Gene

Previous GeneCards Identifiers for CPA5 Gene

  • GC07P128462
  • GC07P129523
  • GC07P129537
  • GC07P129578
  • GC07P129772
  • GC07P129986
  • GC07P124346

Summaries for CPA5 Gene

Entrez Gene Summary for CPA5 Gene

  • Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002 [PubMed 11836249]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CPA5 Gene

CPA5 (Carboxypeptidase A5) is a Protein Coding gene. Diseases associated with CPA5 include Amebiasis and Silver-Russell Syndrome. GO annotations related to this gene include peptidase activity and carboxypeptidase activity. An important paralog of this gene is CPA1.

Gene Wiki entry for CPA5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPA5 Gene

Genomics for CPA5 Gene

Regulatory Elements for CPA5 Gene

Enhancers for CPA5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G130362 2.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 59.7 +24.3 24291 12.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 SLC30A9 ZNF143 ZNF263 MCM3 NFYC CPA5 CPA1 CPA2 MEST KLHDC10 CDC26P1 CEP41 CPA4 TMEM209 LOC105375504
GH07G130354 1.5 Ensembl ENCODE dbSUPER 34.4 +12.8 12771 5.7 PKNOX1 ZNF133 SIN3A FEZF1 GLI4 ZNF2 ZNF121 FOS YY2 TSHZ1 CPA5 MEST CPA1 KLHDC10 CPA4 CPA2 COPG2 LOC101928632 LOC105375504
GH07G130349 1.4 Ensembl ENCODE dbSUPER 31.3 +7.2 7191 4.5 HDGF PKNOX1 ZFP64 YY1 FOS ZNF263 MCM3 JUNB TBX21 NFIL3 CPA5 MEST CPA1 CPA4 CPA2 COPG2 LOC101928632
GH07G130409 0.9 ENCODE dbSUPER 19.5 +65.2 65175 1.6 ZNF362 PKNOX1 ZBTB2 ZBTB11 HLF EP300 ZNF507 PBX2 ZBTB17 CPA5 CPA1 MEST CEP41 CPA4 KLHDC10 CPA2 GC07M130398 LOC105375505
GH07G130382 1 dbSUPER 17.2 +40.3 40326 4.4 ATF1 PKNOX1 CREB3L1 ARNT SIN3A TCF12 ZNF766 GATA2 ELK1 FOS CPA5 MEST CPA1 GC07M130398
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CPA5 on UCSC Golden Path with GeneCards custom track

Genomic Location for CPA5 Gene

130,344,790 bp from pter
130,374,709 bp from pter
29,920 bases
Plus strand

Genomic View for CPA5 Gene

Genes around CPA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPA5 Gene

Proteins for CPA5 Gene

  • Protein details for CPA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carboxypeptidase A5
    Protein Accession:
    Secondary Accessions:
    • G3V0G8
    • Q6ZNI6
    • Q86SE2
    • Q86XM3
    • Q8NA08

    Protein attributes for CPA5 Gene

    436 amino acids
    Molecular mass:
    49036 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CPA5 Gene


neXtProt entry for CPA5 Gene

Selected DME Specific Peptides for CPA5 Gene


Post-translational modifications for CPA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CPA5 Gene

Gene Families for CPA5 Gene

Suggested Antigen Peptide Sequences for CPA5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M14 family.
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPA5: view

Function for CPA5 Gene

Enzyme Numbers (IUBMB) for CPA5 Gene

Gene Ontology (GO) - Molecular Function for CPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004181 metallocarboxypeptidase activity IBA,IEA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CPA5: view
genes like me logo Genes that share phenotypes with CPA5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CPA5

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CPA5 Gene

Localization for CPA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPA5 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CPA5 gene
Compartment Confidence
extracellular 4
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CPA5: view

Pathways & Interactions for CPA5 Gene

No Data Available

Interacting Proteins for CPA5 Gene

Gene Ontology (GO) - Biological Process for CPA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with CPA5: view

No data available for Pathways by source and SIGNOR curated interactions for CPA5 Gene

Drugs & Compounds for CPA5 Gene

(1) Drugs for CPA5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 2296
genes like me logo Genes that share compounds with CPA5: view

Transcripts for CPA5 Gene

Unigene Clusters for CPA5 Gene

Carboxypeptidase A5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPA5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a ·
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - - -
SP8: - -

ExUns: 15b

Relevant External Links for CPA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CPA5 Gene

mRNA differential expression in normal tissues according to GTEx for CPA5 Gene

This gene is overexpressed in Testis (x46.7).

Protein differential expression in normal tissues from HIPED for CPA5 Gene

This gene is overexpressed in Pancreatic juice (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CPA5 Gene

Protein tissue co-expression partners for CPA5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CPA5 Gene:


SOURCE GeneReport for Unigene cluster for CPA5 Gene:


mRNA Expression by UniProt/SwissProt for CPA5 Gene:

Tissue specificity: Expression is very low or not detectable.

Evidence on tissue expression from TISSUES for CPA5 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with CPA5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CPA5 Gene

Orthologs for CPA5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CPA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CPA5 34 35
  • 99.08 (n)
(Canis familiaris)
Mammalia CPA5 34 35
  • 89.76 (n)
(Bos Taurus)
Mammalia CPA5 34 35
  • 87.57 (n)
(Mus musculus)
Mammalia Cpa5 34 16 35
  • 84.24 (n)
(Rattus norvegicus)
Mammalia Cpa5 34
  • 82.98 (n)
(Monodelphis domestica)
Mammalia CPA5 35
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia CPA5 35
  • 64 (a)
(Gallus gallus)
Aves CPA5 34 35
  • 66.11 (n)
(Anolis carolinensis)
Reptilia CPA5 35
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4017 36 35
  • 37 (a)
CG7025 36 35
  • 36 (a)
CG3108 36
  • 35 (a)
CG14820 36 35
  • 34 (a)
CG3097 36
  • 33 (a)
CG18585 36 35
  • 32 (a)
CG12374 36 35
  • 30 (a)
CG17633 36 35
  • 30 (a)
CG2915 36 35
  • 30 (a)
CG18415 36
  • 29 (a)
CG4408 36 35
  • 29 (a)
CG15769 36
  • 27 (a)
CG32379 35
  • 27 (a)
CG8539 36 35
  • 26 (a)
CG8560 35
  • 26 (a)
CG8562 35
  • 26 (a)
CG8563 35
  • 26 (a)
CG8945 36
  • 25 (a)
CG18417 35
  • 24 (a)
CG8564 35
  • 17 (a)
(Caenorhabditis elegans)
Secernentea Y18H1A.9 36 35
  • 34 (a)
Y59C2A.1 36
  • 31 (a)
R11A5.7 36
  • 30 (a)
Y47G6A.19 36 35
  • 30 (a)
W01A8.6 36 35
  • 29 (a)
ZC434.9 36 35
  • 29 (a)
T06A4.3 36 35
  • 28 (a)
F02D8.4 35
  • 25 (a)
T06A4.1 35
  • 23 (a)
suro-1 35
  • 19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM14 35
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
-- 35
  • 38 (a)
CSA.11311 35
  • 36 (a)
CSA.4005 35
  • 20 (a)
Species where no ortholog for CPA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CPA5 Gene

Gene Tree for CPA5 (if available)
Gene Tree for CPA5 (if available)

Paralogs for CPA5 Gene

Paralogs for CPA5 Gene

(9) SIMAP similar genes for CPA5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CPA5: view

Variants for CPA5 Gene

Sequence variations from dbSNP and Humsavar for CPA5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000617180 -- 130,364,056(+) AAGGT(C/T)TCACT intron-variant
rs1000841071 -- 130,358,969(+) ACCAT(C/T)GGCAC intron-variant
rs1001440689 -- 130,360,611(+) TTCAT(A/G)TATTT intron-variant
rs1001891949 -- 130,361,015(+) TTAGA(C/T)CCTCG intron-variant
rs1001900491 -- 130,343,498(+) GATGC(A/G)TGCCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CPA5 Gene

Variant ID Type Subtype PubMed ID
esv23964 CNV gain 19812545
esv2735153 CNV deletion 23290073
nsv515945 CNV gain+loss 19592680

Variation tolerance for CPA5 Gene

Residual Variation Intolerance Score: 93.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.65; 89.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPA5 Gene

Disorders for CPA5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CPA5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • amoebiasis
silver-russell syndrome
  • srs
- elite association - COSMIC cancer census association via MalaCards
Search CPA5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CPA5

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CPA5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPA5 Gene

Publications for CPA5 Gene

  1. Identification and characterization of three members of the human metallocarboxypeptidase gene family. (PMID: 11836249) Wei S. … Fricker L.D. (J. Biol. Chem. 2002) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver- Russell syndrome. (PMID: 12676894) Bentley L. … Moore G.E. (J. Med. Genet. 2003) 3 4 64
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64

Products for CPA5 Gene

Sources for CPA5 Gene

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