Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPA5 Gene

protein-coding   GIFtS: 52
GCID: GC07P129986

carboxypeptidase A5

 Explore 5 diseases affiliated with
CPA5 via our new
 Human Malady Compendium 
Biological research products
for CPA5
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Carboxypeptidase A51 2
EC 3.4.17.13 8
EC 3.4.178

External Ids:    HGNC: 157221   Entrez Gene: 939792   Ensembl: ENSG000001585257   OMIM: 6095615   UniProtKB: Q8WXQ83   

Export aliases for CPA5 gene to outside databases

Previous GC identifers: GC07P128462 GC07P129523 GC07P129537 GC07P129578 GC07P129772 GC07P124346


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CPA5:
Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides.
Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region
that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme
(Wei et al., 2002 (PubMed 11836249)).(supplied by OMIM, Mar 2008)

Gene Wiki entry for CPA5


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPA5 gene promoter:
         AML1a   GATA-3   FOXD3   GATA-2   GATA-1   Egr-4   FOXL1   IRF-7A   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPA5 promoter sequence
   Search SABiosciences Chromatin IP Primers for CPA5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32   Ensembl cytogenetic band:  7q32.2   HGNC cytogenetic band: 7q32

CPA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPA5 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P129986:  view genomic region     (about GC identifiers)

Start:
129,984,630 bp from pter      End:
130,008,571 bp from pter
Size:
23,942 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 129,370,012-129,393,954     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CBPA5_HUMAN, Q8WXQ8 (See protein sequence)
Recommended Name: Carboxypeptidase A5 precursor  
Size: 436 amino acids; 49036 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Secreted (By similarity)
Secondary accessions: G3V0G8 Q6ZNI6 Q86SE2 Q86XM3 Q8NA08
Alternative splicing: 3 isoforms:  Q8WXQ8-1   Q8WXQ8-2   Q8WXQ8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CPA5: NX_Q8WXQ8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WXQ8

  • 4 DME Specific Peptides for CPA5 (Q8WXQ8)
     FELRDTG  YHTLEEI  GIHSREW  VLKFSTG 

    CPA5 Protein expression data from MOPED and PaxDb:    About this image 
    CPA5 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001120913.1  NP_001120914.1  NP_525124.3  

    ENSEMBL proteins: 
     ENSP00000419013   ENSP00000420060   ENSP00000418183   ENSP00000419778   ENSP00000419025  
     ENSP00000420237   ENSP00000393045   ENSP00000417314   ENSP00000376907   ENSP00000417886  
     ENSP00000347549  

    Human Recombinant Protein Products for CPA5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CPA5
    OriGene Protein Over-expression Lysate (see all 3): CPA5
    OriGene Custom Protein Services for CPA5 
    GenScript Custom Purified and Recombinant Proteins Services for CPA5
    Novus Biologicals CPA5 Protein
    Novus Biologicals CPA5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CPA5

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    CPA5 for ontologies           About GeneDecksing



    CPA5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CPA5 
    GenScript Custom Superior Antibodies Services for CPA5
    Novus Biologicals CPA5 Antibodies
    Abcam antibodies for CPA5 
    Uscn Antibodies for CPA5
    ThermoFisher Antibodies for CPA5

    Assay Products for CPA5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CPA5
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CPA5


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CPA5 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR003146 Prot_inh_M14A
     IPR000834 Peptidase_M14
     IPR009020 Prot_inh_propept

    Graphical View of Domain Structure for InterPro Entry Q8WXQ8

    ProtoNet protein and cluster: Q8WXQ8

    2 Blocks protein families:
    IPB000834 Zinc carboxypeptidase A metalloprotease (M14)
    IPB003146 Carboxypeptidase activation peptide


    UniProtKB/Swiss-Prot: CBPA5_HUMAN, Q8WXQ8
    Similarity: Belongs to the peptidase M14 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBPA5_HUMAN, Q8WXQ8
    Catalytic activity: Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro

         Enzyme Numbers (IUBMB): EC 3.4.17.11 2 EC 3.4.172

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004180carboxypeptidase activity ----
    GO:0004181metallocarboxypeptidase activity IEA--
    GO:0008233peptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    CPA5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CPA5:
     Increased Salmonella enterica   Proliferating cells 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CPA5 

    miRNA
    Products:
        
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPA5
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CPA5
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPA5 (see all 7)
    OriGene shRNA RFP: CPA5
    OriGene siRNA: CPA5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPA5
    Sirion Biotech Custom design and validation of potent shRNA sequences against CPA5 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CPA5
    Sirion Biotech Customized adenovirus for overexpression of CPA5 
    Sirion Biotech Customized adenovirus for potent knockdown of CPA5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPA5 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPA5 (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): CPA5 (NM_001127442)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPA5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CPA5
    Search LifeMap BioReagents cell lines for CPA5
    Sirion Biotech Customized stable knockdown cell line services for CPA5 
    Sirion Biotech Customized inducible knockdown cell line services for CPA5
    Sirion Biotech Customized stable overexpressing cell line services for CPA5
    Sirion Biotech Customized inducible overexpressing cell line services for CPA5

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPA5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPA5

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    CPA5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CPA5

    5 HMDB Compounds for CPA5    About this table
    CompoundSynonyms CAS #PubMed Ids
    KinetensinIle-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu 103131-69-7--
    Kinetensin 1-8Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe;KT(1-8) 51833-69-3--
    Neuromedin NIle-Pro-Tyr-Ile-Leu;NN 102577-25-3--
    Neuromedin N (1-4)Ile-Pro-Tyr-Ile ----
    ZincZinc (see all 2)7440-66-6--
    Search CenterWatch for drugs/clinical trials and news about CPA5 / CBPA5 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CPA5 gene (3 alternative transcripts): 
    NM_001127441.1  NM_001127442.1  NM_080385.4  

    Unigene Cluster for CPA5:

    Carboxypeptidase A5
    Hs.567642  [show with all ESTs]
    Unigene Representative Sequence: BC042996
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497503 ENST00000463587 ENST00000461828 ENST00000495736 ENST00000494311
    ENST00000466363 ENST00000485477(uc003vpu.1) ENST00000431780 ENST00000474905
    ENST00000393213 ENST00000479492 ENST00000355388(uc010lmd.1 uc003vps.2 uc003vpt.2 uc010lme.1)


    miRNA
    Products:
         
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPA5
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CPA5
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPA5 (see all 7)
    OriGene shRNA RFP: CPA5
    OriGene siRNA: CPA5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPA5
    Sirion Biotech Custom design and validation of potent shRNA sequences against CPA5 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPA5 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPA5 (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): CPA5 (NM_001127442)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPA5 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CPA5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CPA5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPA5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPA5

    Additional cDNA sequence: 

    AF384667.1 AK093288.1 AK131191.1 AK315256.1 AY155228.1 AY155229.1 AY155230.1 BC039362.1 
    BC042996.1 BC053681.1 

    7 DOTS entries:

    DT.438272  DT.91804677  DT.99999929  DT.100757534  DT.95105695  DT.121112280  DT.97791336 

    24/32 AceView cDNA sequences (see all 32):

    AI191876 BC053681 AF384667 BI829757 BK000187 BC042996 BC039362 AY155229 
    AI873306 AA628217 AW072465 BI460963 BX115674 AY155228 AK131191 AK093288 
    BI829108 NM_080385 BI560982 AY155230 AX748034 BI832381 AI688734 AW184014 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CPA5 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a ·
    SP1:                                      -           -           -                                                                                             
    SP2:                                      -           -     -                                                                                                   
    SP3:                                                  -     -     -                                                                                             
    SP4:                                      -     -     -     -                                                                                         -         
    SP5:                                -     -     -     -     -     -     -                                                                                       

    ExUns: 15b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for CPA5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CPA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCTCATCCC
    CPA5 Expression
    About this image
    See CPA5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CPA5

    SOURCE GeneReport for Unigene cluster: Hs.567642

    UniProtKB/Swiss-Prot: CBPA5_HUMAN, Q8WXQ8
    Tissue specificity: Expression is very low or not detectable

        SABiosciences Custom PCR Arrays for CPA5
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CPA5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CPA5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPA5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPA5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPA5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CPA5 gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CPA51 carboxypeptidase A5 66.11(n)
    60.05(a)
      416683  NM_001252256.1  NP_001239185.1 
    lizard
    (Anolis carolinensis)
    Reptilia CPA56
    --
    59(a)
    1 ↔ 1
    GL343819.1(71830-89774)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG40173 carboxypeptidase A 37(a)
    (best of 14)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea Y18H1A.93   -- 34(a)
    (best of 7)
      I(748486-756927)   --


    ENSEMBL Gene Tree for CPA5 (if available)
    TreeFam Gene Tree for CPA5 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CPA5 gene
    CPA62  CPA32  CPB22  CPA42  CPA22  CPO2  CPA12  CPB12  
    9 SIMAP similar genes for CPA5 using alignment to 5 protein entries:     CBPA5_HUMAN (see all proteins):
    CPA1    DKFZp779K1333    CPA2    CPA4    CPA3    CPB1
    CPO    CPA6    CPB2

    CPA5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/517 NCBI SNPs in CPA5 are shown (see all 517    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs746066771,2
    --129982712(+) AAAGAA/GACCAG 3 -- us2k10--------
    rs1812624611,2
    --129982728(+) AAGAGA/CGGTCA 3 -- us2k10--------
    rs1864926891,2
    --129982732(+) GAGGTA/CACCTT 3 -- us2k10--------
    rs1433270921,2
    --129982894(+) TAATTA/CTTTCT 3 -- us2k10--------
    rs359847961,2
    C--129982917(+) TTTTC-/TCTT  
            
    TCTTT
    3 -- us2k10--------
    rs1408272991,2
    C--129982939(+) CTTCT-/TCTTTCT 3 -- us2k10--------
    rs97849771,2
    C,A--129982951(+) ttcttT/Ccttcc 3 -- us2k1 trp31Minor allele frequency- C:0.00NA 2
    rs2013023361,2
    --129982952(+) TCTTT-/CTTC  
            
    CTTCC
    3 -- us2k10--------
    rs1507593681,2
    C--129982972(+) CTTCT-/TTCTTCTT 3 -- us2k10--------
    rs102400471,2
    C--129982986(+) tctttC/Tttttt 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for CPA5 (129984630 - 130008571 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CPA5
         2 CNVs: 70042 52091

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CPA5
    DNA2.0 Custom Variant and Variant Library Synthesis for CPA5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CPA5 for disorders           About GeneDecksing

    OMIM gene information: 609561    OMIM disorders: --

    5 diseases for CPA5:    About MalaCards
    silver-russell syndrome    amebiasis    hermaphroditism    pancreatitis
    carcinoma


    Export disorders for CPA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CPA5 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with CPA5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of three members of the human metallocarboxypeptidase gene family. (PubMed id 11836249)1, 2, 3 Wei S.... Fricker L.D. (2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    5. The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver- Russell syndrome. (PubMed id 12676894)1, 2 Bentley L.... Moore G.E. (2003)
    6. Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region. (PubMed id 11920156)1, 2 Bonora E....Maestrini E. (2002)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium. (PubMed id 9546821)1 (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 93979 HGNC: 15722 AceView: CPA5 Ensembl:ENSG00000158525 euGenes: HUgn93979
    ECgene: CPA5 H-InvDB: CPA5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CPA5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CPA5 gene:
    Search GeneIP for patents involving CPA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for CPA5  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPA5   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CPA5  
     OriGene Protein Over-expression Lysate for CPA5   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CPA5   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPA5   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPA5  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for CPA5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CPA5   OriGene Custom Protein Services for CPA5  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CPA5
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CPA5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPA5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPA5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPA5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPA5
     GenScript Custom Purified and Recombinant Proteins Services for CPA5 GenScript cDNA clones with any tag delivered in your preferred vector for CPA5
     GenScript Custom Assay Services for CPA5 GenScript Custom Superior Antibodies Services for CPA5
     GenScript Custom overexpressing Cell Line Services for CPA5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CPA5 promoter
     Search Chromatin IP Primers for CPA5
     RT2 qPCR Primer Assay in human, mouse, rat CPA5
     Search GNC Networks for CPA5
     SABiosciences Custom PCR Arrays for CPA5
     Search Tocris compounds for CPA5
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CPA5 antibodies
     CPA5 proteins
     CPA5 lysates
     Antibodies for CPA5
     See all of Abcam's Antibodies, Kits and Proteins for CPA5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CPA5 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CPA5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPA5
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CPA5
     SwitchGear Promoter luciferase reporter plasmids for CPA5
     ThermoFisher Antibodies for CPA5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPA5
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CPA5
    Sirion Biotech Customized:
     stable knockdown cell line services for CPA5
     inducible knockdown cell line services for CPA5
     design and validation of potent shRNA sequences against CPA5
     adenovirus for potent knockdown of CPA5
     adenovirus for overexpression of CPA5
     stable overexpressing cell line services for CPA5
     inducible overexpressing cell line services for CPA5
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CPA5 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4