CPA5 Gene
protein-coding GIFtS: 52
GCID: GC07P129986
|
|
carboxypeptidase A5
| |
Aliases for CPA5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Carboxypeptidase A51 2 | | EC 3.4.17.13 8 | | EC 3.4.178 |
Export aliases for CPA5 gene to outside databasesPrevious GC identifers: GC07P128462 GC07P129523 GC07P129537 GC07P129578 GC07P129772 GC07P124346 |
Summaries for CPA5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for CPA5: Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides.Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro regionthat assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme(Wei et al., 2002 (PubMed 11836249)).(supplied by OMIM, Mar 2008) Gene Wiki entry for CPA5
|
Genomic Views for CPA5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CPA5 gene promoter: AML1a GATA-3 FOXD3 GATA-2 GATA-1 Egr-4 FOXL1 IRF-7A Ik-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for CPA5
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPA5 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q32 Ensembl cytogenetic band: 7q32.2 HGNC cytogenetic band: 7q32CPA5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P129986: view genomic region
(about GC identifiers)
Start:
|
129,984,630 bp from pter |
End:
|
130,008,571 bp from pter |
Size:
|
23,942 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 129,370,012-129,393,954 |
|
Proteins for CPA5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: CBPA5_HUMAN, Q8WXQ8 (See
protein sequence)Recommended Name: Carboxypeptidase A5 precursor Size: 436 amino acids; 49036 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Secreted (By similarity)
Secondary accessions: G3V0G8 Q6ZNI6 Q86SE2 Q86XM3 Q8NA08Alternative splicing: 3 isoforms: Q8WXQ8-1 Q8WXQ8-2 Q8WXQ8-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CPA5: NX_Q8WXQ8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WXQ8 4 DME Specific Peptides for CPA5 (Q8WXQ8)
CPA5 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins (3 alternative transcripts):
NP_001120913.1 NP_001120914.1 NP_525124.3 ENSEMBL proteins: ENSP00000419013 ENSP00000420060 ENSP00000418183 ENSP00000419778 ENSP00000419025 ENSP00000420237 ENSP00000393045 ENSP00000417314 ENSP00000376907 ENSP00000417886 ENSP00000347549 Human Recombinant Protein Products for CPA5:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
CPA5 for ontologies About GeneDecksing
CPA5 Antibody Products: Assay Products for CPA5: |
Protein
Domains / Families for CPA5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CPA5 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WXQ8ProtoNet protein and cluster: Q8WXQ8 2 Blocks protein families: IPB000834 Zinc carboxypeptidase A metalloprotease (M14) IPB003146 Carboxypeptidase activation peptide
UniProtKB/Swiss-Prot: CBPA5_HUMAN, Q8WXQ8Similarity: Belongs to the peptidase M14 family |
Function for CPA5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: CBPA5_HUMAN, Q8WXQ8Catalytic activity: Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro Enzyme Numbers (IUBMB): EC 3.4.17.11 2 EC 3.4.172
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
CPA5 for ontologies About GeneDecksing
Phenotypes: 2 GenomeRNAi human phenotypes for CPA5: Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPA5 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPA5 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPA5 |
|
Pathways & Interactions for CPA5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPA5
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- |
CPA5 for ontologies About GeneDecksing
|
Drugs & Compounds for CPA5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for CPA5
5 HMDB Compounds for CPA5 About this table Search CenterWatch for drugs/clinical trials and news about CPA5 / CBPA5 
|
Transcripts for CPA5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for CPA5 gene (3 alternative transcripts): NM_001127441.1 NM_001127442.1 NM_080385.4 Unigene Cluster for CPA5: Carboxypeptidase A5 Hs.567642 [show with all ESTs]Unigene Representative Sequence: BC04299612 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000497503 ENST00000463587 ENST00000461828 ENST00000495736 ENST00000494311 ENST00000466363 ENST00000485477(uc003vpu.1) ENST00000431780 ENST00000474905 ENST00000393213 ENST00000479492 ENST00000355388(uc010lmd.1 uc003vps.2 uc003vpt.2 uc010lme.1)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPA5 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPA5 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Additional cDNA sequence: AF384667.1 AK093288.1 AK131191.1 AK315256.1 AY155228.1 AY155229.1 AY155230.1 BC039362.1 BC042996.1 BC053681.1 7 DOTS entries: DT.438272 DT.91804677 DT.99999929 DT.100757534 DT.95105695 DT.121112280 DT.97791336 24/32 AceView cDNA sequences (see all 32): AI191876 BC053681 AF384667 BI829757 BK000187 BC042996 BC039362 AY155229 AI873306 AA628217 AW072465 BI460963 BX115674 AY155228 AK131191 AK093288 BI829108 NM_080385 BI560982 AY155230 AX748034 BI832381 AI688734 AW184014 GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CPA5 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | |
| SP1: | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |
| SP5: | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 15b | |
| SP1: | |   | |
| SP2: | |   | |
| SP3: | |   | |
| SP4: | |   | |
| SP5: | |   |
ECgene alternative splicing isoforms for CPA5
|
Expression for CPA5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CPA5 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: CCCTCATCCC
 About this image See CPA5 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CPA5
SOURCE GeneReport for Unigene cluster: Hs.567642
UniProtKB/Swiss-Prot: CBPA5_HUMAN, Q8WXQ8Tissue specificity: Expression is very low or not detectable SABiosciences Custom PCR Arrays for CPA5
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CPA5 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CPA5 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPA5 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPA5 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPA5 |
Orthologs for CPA5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CPA5 gene from 4/17 species (see all 17) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
CPA51 |
carboxypeptidase A5 |
66.11(n) 60.05(a) |
  |
416683 NM_001252256.1 NP_001239185.1 |
lizard (Anolis carolinensis) |
Reptilia |
CPA56 |
-- |
59(a) |
1 ↔ 1 |
GL343819.1(71830-89774) |
fruit fly (Drosophila melanogaster) |
Insecta |
CG40173 |
carboxypeptidase A |
37(a) (best of 14) |
  |
-- |
worm (Caenorhabditis elegans) |
Secernentea |
Y18H1A.93 |
-- |
34(a) (best of 7) |
  |
I(748486-756927) -- |
ENSEMBL Gene Tree for CPA5 (if available) TreeFam Gene Tree for CPA5 (if available)  |
Paralogs for CPA5 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for CPA5 gene
- CPA62 CPA32 CPB22 CPA42 CPA22 CPO2 CPA12 CPB12
9 SIMAP similar genes for CPA5 using alignment to 5 protein entries: CBPA5_HUMAN (see all proteins):CPA1 DKFZp779K1333 CPA2 CPA4 CPA3 CPB1 CPO CPA6 CPB2
CPA5 for paralogs About GeneDecksing
|
Genomic Variants for CPA5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 7 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for CPA5 (129984630 - 130008571 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for CPA5 2 CNVs: 70042 52091  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CPA5 |
|
Disorders
/ Diseases for CPA5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CPA5 for disorders About GeneDecksing
OMIM gene information: 609561
OMIM disorders: --
5 diseases for CPA5: About MalaCardssilver-russell syndrome amebiasis hermaphroditism pancreatitis carcinoma Export disorders for CPA5 gene to outside databases
|
Publications for CPA5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CPA5 gene, integrated from 9 sources (see all 13): (articles sorted by number of sources associating them with CPA5) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Identification and characterization of three members of the human metallocarboxypeptidase gene family. (PubMed id 11836249)1, 2, 3 Wei S.... Fricker L.D. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver- Russell syndrome. (PubMed id 12676894)1, 2 Bentley L.... Moore G.E. (2003)
- Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region. (PubMed id 11920156)1, 2 Bonora E....Maestrini E. (2002)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium. (PubMed id 9546821)1 (1998)
|
External Searches for CPA5 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing CPA5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CPA5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CPA5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for CPA5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CPA5 gene: Search GeneIP for patents involving CPA5
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for CPA5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
 | |
 | |
 |
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