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CPA5 Gene

protein-coding   GIFtS: 52
GCID: GC07P129986

Carboxypeptidase A5

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carboxypeptidase A51 2
EC 3.4.17.13 8
EC 3.4.178

External Ids:    HGNC: 157221   Entrez Gene: 939792   Ensembl: ENSG000001585257   OMIM: 6095615   UniProtKB: Q8WXQ83   

Export aliases for CPA5 gene to outside databases

Previous GC identifers: GC07P128462 GC07P129523 GC07P129537 GC07P129578 GC07P129772 GC07P124346


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CPA5 Gene:
Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine
peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid
pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region
activates the enzyme (Wei et al., 2002 (PubMed 11836249)).(supplied by OMIM, Mar 2008)

GeneCards Summary for CPA5 Gene:
CPA5 (carboxypeptidase A5) is a protein-coding gene. GO annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPO.

Gene Wiki entry for CPA5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CPA5 gene promoter:
         AML1a   GATA-3   FOXD3   GATA-2   GATA-1   Egr-4   FOXL1   IRF-7A   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPA5 promoter sequence
   Search Chromatin IP Primers for CPA5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32   Ensembl cytogenetic band:  7q32.2   HGNC cytogenetic band: 7q32

CPA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPA5 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P129986:  view genomic region     (about GC identifiers)

Start:
129,984,630 bp from pter      End:
130,008,571 bp from pter
Size:
23,942 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 129,370,012-129,393,954     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CBPA5_HUMAN, Q8WXQ8 (See protein sequence)
Recommended Name: Carboxypeptidase A5 precursor  
Size: 436 amino acids; 49036 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Secondary accessions: G3V0G8 Q6ZNI6 Q86SE2 Q86XM3 Q8NA08
Alternative splicing: 3 isoforms:  Q8WXQ8-1   Q8WXQ8-2   Q8WXQ8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CPA5: NX_Q8WXQ8

Explore proteomics data for CPA5 at MOPED

4 DME Specific Peptides for CPA5 (Q8WXQ8)
 FELRDTG  YHTLEEI  GIHSREW  VLKFSTG 


See CPA5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001120913.1  NP_001120914.1  NP_525124.3  

ENSEMBL proteins: 
 ENSP00000419013   ENSP00000420060   ENSP00000418183   ENSP00000419778   ENSP00000419025  
 ENSP00000420237   ENSP00000393045   ENSP00000417314   ENSP00000376907   ENSP00000417886  
 ENSP00000347549  

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antibodies-online peptides for CPA5

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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IUPHAR Guide to PHARMACOLOGY protein family classification: Carboxypeptidase A5
Metallocarboxypeptidases

3 InterPro protein domains:
 IPR003146 Prot_inh_M14A
 IPR000834 Peptidase_M14
 IPR009020 Prot_inh_propept

Graphical View of Domain Structure for InterPro Entry Q8WXQ8

ProtoNet protein and cluster: Q8WXQ8

2 Blocks protein domains:
IPB000834 Zinc carboxypeptidase A metalloprotease (M14)
IPB003146 Carboxypeptidase activation peptide


UniProtKB/Swiss-Prot: CBPA5_HUMAN, Q8WXQ8
Similarity: Belongs to the peptidase M14 family


Find genes that share domains with CPA5           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CBPA5_HUMAN, Q8WXQ8
Catalytic activity: Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or
-Pro

     Enzyme Numbers (IUBMB): EC 3.4.17.11 2 EC 3.4.172

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004180carboxypeptidase activity ----
GO:0004181metallocarboxypeptidase activity IEA--
GO:0008233peptidase activity ----
GO:0008270zinc ion binding IEA--
     
Find genes that share ontologies with CPA5           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for CPA5:
 Increased Salmonella enterica   Proliferating cells 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for CPA5

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CBPA5_HUMAN, Q8WXQ8: Secreted (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular2
endoplasmic reticulum1
lysosome1
mitochondrion1
peroxisome1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

Find genes that share ontologies with CPA5           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CPA5
Interactions:

    Search GeneGlobe Interaction Network for CPA5

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

Selected Interacting proteins for CPA5 (ENSP000003475494) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
InteractantInteraction Details
GeneCardExternal ID(s)
CELA3AENSP000002901224STRING: ENSP00000290122
CELA3BENSP000003383694STRING: ENSP00000338369
CELA2AENSP000003526394STRING: ENSP00000352639
CELA2BENSP000003650754STRING: ENSP00000365075
CTRCENSP000003651164STRING: ENSP00000365116
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006508proteolysis ----

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CPA5 (CBPA5)

5 HMDB Compounds for CPA5    About this table
CompoundSynonyms CAS #PubMed Ids
KinetensinIle-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu 103131-69-7--
Kinetensin 1-8Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe;KT(1-8) 51833-69-3--
Neuromedin NIle-Pro-Tyr-Ile-Leu;NN 102577-25-3--
Neuromedin N (1-4)Ile-Pro-Tyr-Ile ----
ZincZinc (see all 2)7440-66-6--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CPA5 gene (3 alternative transcripts): 
NM_001127441.1  NM_001127442.1  NM_080385.4  

Unigene Cluster for CPA5:

Carboxypeptidase A5
Hs.567642  [show with all ESTs]
Unigene Representative Sequence: BC042996
12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000497503 ENST00000463587 ENST00000461828 ENST00000495736 ENST00000494311
ENST00000466363 ENST00000485477(uc003vpu.1) ENST00000431780 ENST00000474905
ENST00000393213 ENST00000479492 ENST00000355388(uc010lmd.1 uc003vps.2 uc003vpt.2 uc010lme.1)

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Additional mRNA sequence: 

AF384667.1 AK093288.1 AK131191.1 AK315256.1 AY155228.1 AY155229.1 AY155230.1 BC039362.1 
BC042996.1 BC053681.1 

7 DOTS entries:

DT.438272  DT.91804677  DT.99999929  DT.100757534  DT.95105695  DT.121112280  DT.97791336 

Selected AceView cDNA sequences (see all 32):

BC053681 AI191876 BK000187 BI829757 AF384667 AY155229 BC042996 AX748034 
AY155228 AK131191 NM_080385 AK093288 AW072465 BI560982 AY155230 AI873306 
BC039362 BX115674 BI460963 AA628217 BI829108 BI459441 BI832381 AI188127 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for CPA5 (see all 8)    About this scheme

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a ·
SP1:                                      -           -           -                                                                                             
SP2:                                      -           -     -                                                                                                   
SP3:                                                  -     -     -                                                                                             
SP4:                                      -     -     -     -                                                                                         -         
SP5:                                -     -     -     -     -     -     -                                                                                       

ExUns: 15b
SP1:      
SP2:      
SP3:      
SP4:      
SP5:      


ECgene alternative splicing isoforms for CPA5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CPA5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCCTCATCCC
CPA5 Expression
About this image

CPA5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CPA5 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.567642

UniProtKB/Swiss-Prot: CBPA5_HUMAN, Q8WXQ8
Tissue specificity: Expression is very low or not detectable

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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for CPA5 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cpa51 , 5 carboxypeptidase A51, 5 84.24(n)1
84.8(a)1
  6 (12.52 cM)5
746491  NM_144537.31  NP_653120.11 
 306110105 
chicken
(Gallus gallus)
Aves CPA51 carboxypeptidase A5 66.11(n)
60.05(a)
  416683  NM_001252256.1  NP_001239185.1 
lizard
(Anolis carolinensis)
Reptilia CPA56
carboxypeptidase A5
58(a)
1 ↔ 1
GL343819.1(71453-89806)
fruit fly
(Drosophila melanogaster)
Insecta CG40173 carboxypeptidase A 37(a)
(best of 14)
    --
worm
(Caenorhabditis elegans)
Secernentea Y18H1A.93   -- 34(a)
(best of 7)
  I(748486-756927)   --
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM146
Putative metalloprotease with similarity to the zi...
24(a)
1 → many
VIII(368502-369794) YHR132C


ENSEMBL Gene Tree for CPA5 (if available)
TreeFam Gene Tree for CPA5 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CPA5 gene
CPO2  CPA22  CPA12  CPB12  CPA62  CPA32  CPB22  CPA42  
9 SIMAP similar genes for CPA5 using alignment to 5 protein entries:     CBPA5_HUMAN (see all proteins):
CPA1    DKFZp779K1333    CPA2    CPA4    CPA3    CPB1
CPO    CPA6    CPB2

Find genes that share paralogs with CPA5           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CPA5 (see all 644)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs746066771,2
C--129982712(+) AAAGAA/GACCAG 3 -- us2k10--------
rs1812624611,2
--129982728(+) AAGAGA/CGGTCA 3 -- us2k10--------
rs1864926891,2
--129982732(+) GAGGTA/CACCTT 3 -- us2k10--------
rs1433270921,2
--129982894(+) TAATTA/CTTTCT 3 -- us2k10--------
rs359847961,2
C--129982917(+) TTTTC-/TCTT  
        
TCTTT
3 -- us2k10--------
rs2002778271,2
C--129982934(+) TCTTT-/CTTCTT 3 -- us2k10--------
rs97849771,2
C,F,A--129982951(+) ttcttT/Ccttcc 3 -- us2k1 trp31Minor allele frequency- C:0.00NA 2
rs2013023361,2
C--129982952(+) TCTTT-/CTTC  
        
CTTCC
3 -- us2k10--------
rs1507593681,2
C--129982972(+) CTTCT-/TTCTTCTT 3 -- us2k10--------
rs102400471,2
C--129982986(+) tctttC/Tttttt 3 -- us2k10--------

HapMap Linkage Disequilibrium report for CPA5 (129984630 - 130008571 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for CPA5:    About this table    
Variant IDTypeSubtypePubMed ID
esv2735153CNV Deletion23290073
esv23964CNV Gain19812545
nsv515945CNV Gain+Loss19592680

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CPA5
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 609561    OMIM disorders: --


Find genes that share disorders with CPA5           About GenesLikeMe

Genetic Association Database (GAD): CPA5

Export disorders for CPA5 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CPA5 gene, integrated from 10 sources (see all 13):
(articles sorted by number of sources associating them with CPA5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification and characterization of three members of the human metallocarboxypeptidase gene family. (PubMed id 11836249)1, 2, 3 Wei S.... Fricker L.D. (J. Biol. Chem. 2002)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
  5. The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver- Russell syndrome. (PubMed id 12676894)1, 2 Bentley L.... Moore G.E. (J. Med. Genet. 2003)
  6. Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region. (PubMed id 11920156)1, 2 Bonora E....Maestrini E. (Mol. Psychiatry 2002)
  7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  10. A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium. (PubMed id 9546821)1 (Hum. Mol. Genet. 1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 93979 HGNC: 15722 AceView: CPA5 Ensembl:ENSG00000158525 euGenes: HUgn93979
ECgene: CPA5 H-InvDB: CPA5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CPA5 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CPA5 gene:
Search GeneIP for patents involving CPA5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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