CPA4 Gene

Aliases
for CPA4 gene

Previous GC identifers: GC07P128409 GC07P129472 GC07P129485 GC07P129526 GC07P129720 GC07P124295

Summaries
for CPA4 gene

Genomic Views
for CPA4 gene

RefSeq DNA sequence:

NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  

SwitchGear Promoter luciferase reporter plasmid: CPA4 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPA4

CPA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P129932:  view genomic region     (about GC identifiers)

Proteins
for CPA4 gene

4 PDB 3D structures from and Proteopedia for CPA4:

2BO9 (3D)        2BOA (3D)        2PCU (3D)        4A94 (3D)    

Explore the universe of human proteins at neXtProt for CPA4: NX_Q9UI42

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CPA4 (Carboxypeptidase A4/CPA4)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CPA4 OriGene Protein Over-expression Lysate (see all 2): CPA4 OriGene Custom Protein Services for CPA4
	GenScript Custom Purified and Recombinant Proteins Services for CPA4
	Novus Biologicals CPA4 Protein Novus Biologicals CPA4 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CPA4

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for CPA4
	GenScript Custom Superior Antibodies Services for CPA4
	Novus Biologicals CPA4 Antibodies
	Abcam antibodies for CPA4
	Uscn Antibodies for CPA4
	ThermoFisher Antibodies for CPA4

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CPA4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CPA4

Protein Domains /
Families
for CPA4 gene

ProtoNet protein and cluster: Q9UI42

Function
for CPA4 gene

Enzyme Numbers (IUBMB): EC 3.4.17² EC 3.4.17.-¹ EC 3.4.17.1²

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CPA4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPA4
		8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate CPA4 (see all 29):
		hsa-miR-34b* hsa-miR-362-3p hsa-let-7d hsa-miR-3616-5p hsa-miR-202 hsa-let-7c hsa-miR-3190 hsa-let-7g
		SwitchGear 3'UTR luciferase reporter plasmid: CPA4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CPA4 (see all 7) OriGene shRNA RFP: CPA4 OriGene siRNA: CPA4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPA4

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CPA4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CPA4 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CPA4 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CPA4 (NM_016352)
		Sino Biological Human cDNA Clone for CPA4
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPA4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPA4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CPA4
		Search LifeMap BioReagents cell lines for CPA4

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPA4

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for CPA4 gene

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for CPA4 gene

Transcripts
for CPA4 gene

Expression
for CPA4 gene

CPA4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Stem Cell Differentiation: 5 LifeMap Cells
	Name			Category
	PureStem™ progenitor T42 (Embryonic Progenitor Cell)
	PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
	PureStem™ progenitor T36 (Embryonic Progenitor Cell)
	PureStem™ progenitor W10 (Embryonic Progenitor Cell)
	PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CPA4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CPA4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPA4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPA4

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPA4

Orthologs
for CPA4 gene

Paralogs
for CPA4 gene

Paralogs for CPA4 gene

CPA6²  CPA3²  CPB2²  CPA2²  CPO²  CPA1²  CPB1²  CPA5²  

9 SIMAP similar genes for CPA4 using alignment to 7 protein entries:     CBPA4_HUMAN (see all proteins):

CPA1    DKFZp779K1333    CPA5    CPA2    CPO    CPA6

CPA3    CPB1    CPB2

CPA4 for paralogs           About GeneDecksing

Genomic Variants
for CPA4 gene

10/637 NCBI SNPs in CPA4 are shown (see all 637)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1130004251,2		--	129316700(+)	GTTCTC/TGTTGC	2	--	us2k1		1		CSA	2
rs24029921,2	C,F,H,	--	129316894(+)	CTGCAC/GCCTCC	2	--	us2k1 trp3		11		NS EA NA CSA WA	760
rs802678271,2	F,	--	129316956(+)	CCTGCG/AAAGTC	2	--	us2k1		1		NA	120
rs752223991,2	C,	--	129317157(+)	TAGCCA/GTGGTC	2	--	us2k1		2		NA	122
rs624895011,2	F,	--	129317392(+)	TGTCTT/GCCATT	2	--	us2k1		4		NA CSA WA	242
rs561553121,2	C,F,	--	129317505(+)	TCTGTC/TGCCCA	2	--	us2k1		2		NA	4
rs561920271,2		--	129317733(+)	CAGGCA/GTGAGC	2	--	us2k1		0	--	--	--	--
rs624895021,2	C,F,	--	129318010(+)	TCTTGC/ATTTGA	2	--	us2k1		3		NA	124
rs767460371,2	F,	--	129318222(+)	TAAATT/CGAGAT	2	--	us2k1		1		NA	120
rs731467841,2	C,F,	--	129318332(+)	TTGAGG/TACTTG	2	--	us2k1		1		NA	120

HapMap Linkage Disequilibrium report for CPA4 (129932974 - 129964020 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for CPA4: --
Human Gene Mutation Database (HGMD): CPA4

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CPA4

DNA2.0 Custom Variant and Variant Library Synthesis for CPA4

Disorders / Diseases
for CPA4 gene

Publications
for CPA4 gene

PubMed articles for CPA4 gene, integrated from 9 sources (see all 19): (articles sorted by number of sources associating them with CPA4)

Utopia: connect your pdf to the dynamic world of online information

1. Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells. (PubMed id 10383164)^{1, 2, 3} Huang H.... Smith D.I. (1999)
2. Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin. (PubMed id 15738388)^{1, 2, 9} Pallares I.... Gomis-Rueth F.-X. (2005)
3. Detailed molecular comparison between the inhibition mode of A/B-type carboxypeptidases in the zymogen state and by the endogenous inhibitor latexin. (PubMed id 16091843)^{1, 2} Garcia-Castellanos R.... Gomis-Rueth F.-X. (2005)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
6. The novel imprinted carboxypeptidase A4 gene (CPA4) in the 7q32 imprinting domain. (PubMed id 12552318)^{1, 2} Kayashima T.... Kishino T. (2003)
7. Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32. (PubMed id 10860668)^{1, 3} Hayashida S....Kishino T. (2000)
8. Characterization of the substrate specificity of huma n carboxypeptidase A4 and implications for a role in extracellular peptide proc essing. (PubMed id 20385563)^{1, 9} Tanco S....Fricker L.D. (2010)
9. Carboxypeptidase 4 gene variants and early-onset intermediate-to-high risk prostate cancer. (PubMed id 19245716)^{1, 9} Ross P.L....Witte J.S. (2009)
10. Crystal structure of novel metallocarboxypeptidase inh ibitor from marine mollusk Nerita versicolor in complex with human carboxypeptid ase A4. (PubMed id 22294694)¹ Covaleda G....Reverter D. (2012)

External Searches for CPA4 gene

Genome Databases showing CPA4 gene

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Specialized Databases showing CPA4 gene

Products
for CPA4 gene