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Aliases for CPA4 Gene

Aliases for CPA4 Gene

  • Carboxypeptidase A4 2 3 5
  • Carboxypeptidase A3 2 3 4
  • CPA3 3 4
  • EC 3.4.17.1 63
  • EC 3.4.17.- 4
  • EC 3.4.17 63

External Ids for CPA4 Gene

Previous GeneCards Identifiers for CPA4 Gene

  • GC07P128409
  • GC07P129472
  • GC07P129485
  • GC07P129526
  • GC07P129720
  • GC07P129932
  • GC07P124295

Summaries for CPA4 Gene

Entrez Gene Summary for CPA4 Gene

  • This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPA4 Gene

CPA4 (Carboxypeptidase A4) is a Protein Coding gene. Diseases associated with CPA4 include Silver-Russell Syndrome and Gliosarcoma. GO annotations related to this gene include metallocarboxypeptidase activity and carboxypeptidase activity. An important paralog of this gene is CPA3.

UniProtKB/Swiss-Prot for CPA4 Gene

  • Metalloprotease that could be involved in the histone hyperacetylation pathway.

Gene Wiki entry for CPA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPA4 Gene

Genomics for CPA4 Gene

Regulatory Elements for CPA4 Gene

Enhancers for CPA4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CPA4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CPA4 Gene

Chromosome:
7
Start:
130,293,134 bp from pter
End:
130,324,180 bp from pter
Size:
31,047 bases
Orientation:
Plus strand

Genomic View for CPA4 Gene

Genes around CPA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPA4 Gene

Proteins for CPA4 Gene

  • Protein details for CPA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UI42-CBPA4_HUMAN
    Recommended name:
    Carboxypeptidase A4
    Protein Accession:
    Q9UI42
    Secondary Accessions:
    • B7Z576
    • Q86UY9

    Protein attributes for CPA4 Gene

    Size:
    421 amino acids
    Molecular mass:
    47351 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Monomer. Interacts with LXN.

    Three dimensional structures from OCA and Proteopedia for CPA4 Gene

    Alternative splice isoforms for CPA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPA4 Gene

Proteomics data for CPA4 Gene at MOPED

Selected DME Specific Peptides for CPA4 Gene

Post-translational modifications for CPA4 Gene

  • Glycosylation at Asn 260
  • Modification sites at PhosphoSitePlus

Other Protein References for CPA4 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for CPA4

Domains & Families for CPA4 Gene

Gene Families for CPA4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UI42

UniProtKB/Swiss-Prot:

CBPA4_HUMAN :
  • Belongs to the peptidase M14 family.
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPA4: view

Function for CPA4 Gene

Molecular function for CPA4 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=55.6 uM for 3-(2-furyl)acryloyl-Phe-Phe {ECO:0000269 PubMed:20385563}; KM=19.4 uM for 3-(2-furyl)acryloyl-Phe-Leu {ECO:0000269 PubMed:20385563}; KM=23.3 uM for 3-(2-furyl)acryloyl-Phe-Ile {ECO:0000269 PubMed:20385563}; KM=40.4 uM for 3-(2-furyl)acryloyl-Phe-Met {ECO:0000269 PubMed:20385563}; KM=57.3 uM for 3-(2-furyl)acryloyl-Phe-Val {ECO:0000269 PubMed:20385563}; KM=0.329 uM for neurotensin {ECO:0000269 PubMed:20385563}; KM=9.23 uM for Met-enkephalin-Arg-Phe {ECO:0000269 PubMed:20385563}; pH dependence: Optimum pH is 8.5-9. {ECO:0000269 PubMed:20385563};
UniProtKB/Swiss-Prot CatalyticActivity:
Release of a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by interaction with the metallocarboxypeptidase inhibitor (MCPI) from N.versicolor that binds to the catalytic zinc ion.
UniProtKB/Swiss-Prot Function:
Metalloprotease that could be involved in the histone hyperacetylation pathway.
UniProtKB/Swiss-Prot Induction:
Up-regulated by inhibitors of histone dacetylation.

Enzyme Numbers (IUBMB) for CPA4 Gene

genes like me logo Genes that share phenotypes with CPA4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CPA4

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CPA4 Gene

Localization for CPA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPA4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPA4 Gene COMPARTMENTS Subcellular localization image for CPA4 gene
Compartment Confidence
extracellular 5
cytoskeleton 2
cytosol 2
nucleus 2
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CPA4 Gene

Pathways & Interactions for CPA4 Gene

SuperPathways for CPA4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CPA4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CPA4 Gene

Drugs & Compounds for CPA4 Gene

No Compound Related Data Available

Transcripts for CPA4 Gene

Unigene Clusters for CPA4 Gene

Carboxypeptidase A4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPA4 Gene

No ASD Table

Relevant External Links for CPA4 Gene

GeneLoc Exon Structure for
CPA4
ECgene alternative splicing isoforms for
CPA4

Expression for CPA4 Gene

mRNA expression in normal human tissues for CPA4 Gene

mRNA differential expression in normal tissues according to GTEx for CPA4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x11.0), Skin - Sun Exposed (Lower leg) (x9.1), Esophagus - Mucosa (x7.1), Minor Salivary Gland (x5.9), and Cervix - Ectocervix (x4.6).

Protein differential expression in normal tissues from HIPED for CPA4 Gene

This gene is overexpressed in Bone (36.8) and Amniocyte (25.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPA4 Gene



SOURCE GeneReport for Unigene cluster for CPA4 Gene Hs.93764

mRNA Expression by UniProt/SwissProt for CPA4 Gene

Q9UI42-CBPA4_HUMAN
Tissue specificity: Fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver and lung. Except for fetal brain that shows no imprinting, expression was found preferentially from the maternal allele.
genes like me logo Genes that share expression patterns with CPA4: view

Primer Products

No data available for Protein tissue co-expression partners for CPA4 Gene

Orthologs for CPA4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CPA4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CPA4 35
  • 81.27 (n)
  • 71.67 (a)
CPA4 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPA4 35
  • 89.15 (n)
  • 88.84 (a)
CPA4 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpa4 35
  • 85.08 (n)
  • 84.05 (a)
Cpa4 16
Cpa4 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CPA4 35
  • 99.13 (n)
  • 98.81 (a)
CPA4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpa4 35
  • 84.92 (n)
  • 84.76 (a)
oppossum
(Monodelphis domestica)
Mammalia CPA4 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
chicken
(Gallus gallus)
Aves CPA2 36
  • 60 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii cpa2 36
  • 51 (a)
ManyToMany
cpa4 36
  • 57 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12374 37
  • 30 (a)
CG14820 37
  • 30 (a)
CG15769 37
  • 26 (a)
CG17633 37
  • 33 (a)
CG18415 37
  • 30 (a)
CG18417 37
  • 36 (a)
CG18585 37
  • 31 (a)
CG2915 37
  • 28 (a)
CG3097 37
  • 35 (a)
CG3108 37
  • 37 (a)
CG4017 37
  • 35 (a)
CG4408 37
  • 31 (a)
CG7025 37
  • 36 (a)
CG8539 37
  • 30 (a)
CG8560 37
  • 33 (a)
CG8562 37
  • 29 (a)
CG8563 37
  • 33 (a)
CG8945 37
  • 26 (a)
CG3108 35
  • 50.36 (n)
  • 39.07 (a)
CG12374 36
  • 28 (a)
ManyToMany
CG14820 36
  • 30 (a)
ManyToMany
CG17633 36
  • 30 (a)
ManyToMany
CG18417 36
  • 29 (a)
ManyToMany
CG18585 36
  • 30 (a)
ManyToMany
CG2915 36
  • 26 (a)
ManyToMany
CG32379 36
  • 29 (a)
ManyToMany
CG4017 36
  • 33 (a)
ManyToMany
CG4408 36
  • 26 (a)
ManyToMany
CG7025 36
  • 31 (a)
ManyToMany
CG8539 36
  • 25 (a)
ManyToMany
CG8560 36
  • 32 (a)
ManyToMany
CG8562 36
  • 29 (a)
ManyToMany
CG8563 36
  • 32 (a)
ManyToMany
CG8564 36
  • 17 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000621 35
  • 48.88 (n)
  • 39.95 (a)
worm
(Caenorhabditis elegans)
Secernentea R11A5.7 37
  • 31 (a)
T06A4.3 37
  • 30 (a)
W01A8.6 37
  • 31 (a)
Y18H1A.9 37
  • 35 (a)
Y47G6A.19 37
  • 33 (a)
Y59C2A.1 37
  • 32 (a)
ZC434.9 37
  • 31 (a)
F02D8.4 36
  • 28 (a)
ManyToMany
suro-1 36
  • 21 (a)
ManyToMany
T06A4.1 36
  • 25 (a)
ManyToMany
T06A4.3 36
  • 27 (a)
ManyToMany
W01A8.6 36
  • 28 (a)
ManyToMany
Y18H1A.9 36
  • 31 (a)
ManyToMany
Y47G6A.19 36
  • 29 (a)
ManyToMany
ZC434.9 36
  • 19 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM14 36
  • 28 (a)
OneToMany
ECM14 38
bread mold
(Neurospora crassa)
Ascomycetes NCU07536 35
  • 49.34 (n)
  • 39.16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
CSA.11311 36
  • 38 (a)
ManyToMany
CSA.4005 36
  • 20 (a)
ManyToMany
Species with no ortholog for CPA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CPA4 Gene

ENSEMBL:
Gene Tree for CPA4 (if available)
TreeFam:
Gene Tree for CPA4 (if available)

Paralogs for CPA4 Gene

Paralogs for CPA4 Gene

(9) SIMAP similar genes for CPA4 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CPA4: view

Variants for CPA4 Gene

Sequence variations from dbSNP and Humsavar for CPA4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs3735051 - 130,304,562(+) ACCGG(A/C)CGATG reference, missense
rs2171492 - 130,310,900(+) TCAAG(G/T)GCTTC reference, missense
rs34587586 - 130,298,758(+) GTTTT(C/G/T)AGGAT reference, missense
rs3735053 - 130,305,877(+) TTCCC(A/G/T)AGAGT reference, missense
rs901798 -- 130,291,174(+) CTATG(A/G)TCGCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CPA4 Gene

Variant ID Type Subtype PubMed ID
esv272094 CNV Insertion 20981092

Variation tolerance for CPA4 Gene

Residual Variation Intolerance Score: 85.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.46; 97.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPA4 Gene

Human Gene Mutation Database (HGMD)
CPA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPA4 Gene

Disorders for CPA4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CPA4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
silver-russell syndrome
  • silver russell dwarfism
gliosarcoma
  • glioblastoma with sarcomatous component
- elite association - COSMIC cancer census association via MalaCards
Search CPA4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CPA4

Genetic Association Database (GAD)
CPA4
Human Genome Epidemiology (HuGE) Navigator
CPA4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPA4
genes like me logo Genes that share disorders with CPA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPA4 Gene

Publications for CPA4 Gene

  1. Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells. (PMID: 10383164) Huang H. … Smith D.I. (Cancer Res. 1999) 2 3 4 67
  2. Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing. (PMID: 20385563) Tanco S. … Fricker L.D. (J. Biol. Chem. 2010) 3 23
  3. Carboxypeptidase 4 gene variants and early-onset intermediate-to-high risk prostate cancer. (PMID: 19245716) Ross P.L. … Witte J.S. (BMC Cancer 2009) 3 23
  4. Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin. (PMID: 15738388) Pallares I. … Gomis-Rueth F.-X. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 23
  5. Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32. (PMID: 10860668) Hayashida S. … Kishino T. (Genomics 2000) 2 3

Products for CPA4 Gene

Sources for CPA4 Gene

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