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Aliases for CPA4 Gene

Aliases for CPA4 Gene

  • Carboxypeptidase A4 2 3
  • Carboxypeptidase A3 2 3 4
  • CPA3 3 4
  • EC 63
  • EC 3.4.17.- 4
  • EC 3.4.17 63

External Ids for CPA4 Gene

Previous GeneCards Identifiers for CPA4 Gene

  • GC07P128409
  • GC07P129472
  • GC07P129485
  • GC07P129526
  • GC07P129720
  • GC07P129932
  • GC07P124295

Summaries for CPA4 Gene

Entrez Gene Summary for CPA4 Gene

  • This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPA4 Gene

CPA4 (Carboxypeptidase A4) is a Protein Coding gene. Diseases associated with CPA4 include silver-russell syndrome and gliosarcoma. Among its related pathways are Transport to the Golgi and subsequent modification and Pancreatic secretion. GO annotations related to this gene include metallocarboxypeptidase activity and carboxypeptidase activity. An important paralog of this gene is CPA3.

UniProtKB/Swiss-Prot for CPA4 Gene

  • Metalloprotease that could be involved in the histone hyperacetylation pathway.

Gene Wiki entry for CPA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPA4 Gene

Genomics for CPA4 Gene

Regulatory Elements for CPA4 Gene

Genomic Location for CPA4 Gene

130,293,134 bp from pter
130,324,180 bp from pter
31,047 bases
Plus strand

Genomic View for CPA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPA4 Gene

Proteins for CPA4 Gene

  • Protein details for CPA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carboxypeptidase A4
    Protein Accession:
    Secondary Accessions:
    • B7Z576
    • Q86UY9

    Protein attributes for CPA4 Gene

    421 amino acids
    Molecular mass:
    47351 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Monomer. Interacts with LXN.

    Three dimensional structures from OCA and Proteopedia for CPA4 Gene

    Alternative splice isoforms for CPA4 Gene


neXtProt entry for CPA4 Gene

Proteomics data for CPA4 Gene at MOPED

Selected DME Specific Peptides for CPA4 Gene

Post-translational modifications for CPA4 Gene

  • Glycosylation at Asn 260
  • Modification sites at PhosphoSitePlus

Other Protein References for CPA4 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for CPA4

Domains & Families for CPA4 Gene

Gene Families for CPA4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M14 family.
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPA4: view

Function for CPA4 Gene

Molecular function for CPA4 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=55.6 uM for 3-(2-furyl)acryloyl-Phe-Phe {ECO:0000269 PubMed:20385563}; KM=19.4 uM for 3-(2-furyl)acryloyl-Phe-Leu {ECO:0000269 PubMed:20385563}; KM=23.3 uM for 3-(2-furyl)acryloyl-Phe-Ile {ECO:0000269 PubMed:20385563}; KM=40.4 uM for 3-(2-furyl)acryloyl-Phe-Met {ECO:0000269 PubMed:20385563}; KM=57.3 uM for 3-(2-furyl)acryloyl-Phe-Val {ECO:0000269 PubMed:20385563}; KM=0.329 uM for neurotensin {ECO:0000269 PubMed:20385563}; KM=9.23 uM for Met-enkephalin-Arg-Phe {ECO:0000269 PubMed:20385563}; pH dependence: Optimum pH is 8.5-9. {ECO:0000269 PubMed:20385563};
UniProtKB/Swiss-Prot CatalyticActivity:
Release of a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by interaction with the metallocarboxypeptidase inhibitor (MCPI) from N.versicolor that binds to the catalytic zinc ion.
UniProtKB/Swiss-Prot Function:
Metalloprotease that could be involved in the histone hyperacetylation pathway.
UniProtKB/Swiss-Prot Induction:
Up-regulated by inhibitors of histone dacetylation.

Enzyme Numbers (IUBMB) for CPA4 Gene

Gene Ontology (GO) - Molecular Function for CPA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity --
GO:0004181 metallocarboxypeptidase activity NAS 10383164
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CPA4: view

Phenotypes for CPA4 Gene

GenomeRNAi human phenotypes for CPA4:
genes like me logo Genes that share phenotypes with CPA4: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPA4

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CPA4 Gene

Localization for CPA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPA4 Gene


Subcellular locations from

Jensen Localization Image for CPA4 Gene COMPARTMENTS Subcellular localization image for CPA4 gene
Compartment Confidence
extracellular 3
cytoskeleton 2
cytosol 2
nucleus 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CPA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CPA4: view

Pathways & Interactions for CPA4 Gene

genes like me logo Genes that share pathways with CPA4: view

Gene Ontology (GO) - Biological Process for CPA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IBA --
GO:0016573 histone acetylation NAS 10383164
genes like me logo Genes that share ontologies with CPA4: view

No data available for SIGNOR curated interactions for CPA4 Gene

Drugs & Compounds for CPA4 Gene

No Compound Related Data Available

Transcripts for CPA4 Gene

Unigene Clusters for CPA4 Gene

Carboxypeptidase A4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPA4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPA4 Gene

No ASD Table

Relevant External Links for CPA4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CPA4 Gene

mRNA expression in normal human tissues for CPA4 Gene

mRNA differential expression in normal tissues according to GTEx for CPA4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x11.0), Skin - Sun Exposed (Lower leg) (x9.1), Esophagus - Mucosa (x7.1), Minor Salivary Gland (x5.9), and Cervix - Ectocervix (x4.6).

Protein differential expression in normal tissues from HIPED for CPA4 Gene

This gene is overexpressed in Bone (36.8) and Amniocyte (25.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPA4 Gene

SOURCE GeneReport for Unigene cluster for CPA4 Gene Hs.93764

mRNA Expression by UniProt/SwissProt for CPA4 Gene

Tissue specificity: Fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver and lung. Except for fetal brain that shows no imprinting, expression was found preferentially from the maternal allele
genes like me logo Genes that share expression patterns with CPA4: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for CPA4 Gene

Orthologs for CPA4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CPA4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CPA4 35
  • 81.27 (n)
  • 71.67 (a)
CPA4 36
  • 72 (a)
(Canis familiaris)
Mammalia CPA4 35
  • 89.15 (n)
  • 88.84 (a)
CPA4 36
  • 89 (a)
(Mus musculus)
Mammalia Cpa4 35
  • 85.08 (n)
  • 84.05 (a)
Cpa4 16
Cpa4 36
  • 84 (a)
(Pan troglodytes)
Mammalia CPA4 35
  • 99.13 (n)
  • 98.81 (a)
CPA4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cpa4 35
  • 84.92 (n)
  • 84.76 (a)
(Monodelphis domestica)
Mammalia CPA4 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
-- 36
  • 50 (a)
(Gallus gallus)
Aves CPA2 36
  • 60 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
(Danio rerio)
Actinopterygii cpa2 36
  • 51 (a)
cpa4 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12374 37
  • 30 (a)
CG14820 37
  • 30 (a)
CG15769 37
  • 26 (a)
CG17633 37
  • 33 (a)
CG18415 37
  • 30 (a)
CG18417 37
  • 36 (a)
CG18585 37
  • 31 (a)
CG2915 37
  • 28 (a)
CG3097 37
  • 35 (a)
CG3108 37
  • 37 (a)
CG4017 37
  • 35 (a)
CG4408 37
  • 31 (a)
CG7025 37
  • 36 (a)
CG8539 37
  • 30 (a)
CG8560 37
  • 33 (a)
CG8562 37
  • 29 (a)
CG8563 37
  • 33 (a)
CG8945 37
  • 26 (a)
CG3108 35
  • 50.36 (n)
  • 39.07 (a)
CG12374 36
  • 28 (a)
CG14820 36
  • 30 (a)
CG17633 36
  • 30 (a)
CG18417 36
  • 29 (a)
CG18585 36
  • 30 (a)
CG2915 36
  • 26 (a)
CG32379 36
  • 29 (a)
CG4017 36
  • 33 (a)
CG4408 36
  • 26 (a)
CG7025 36
  • 31 (a)
CG8539 36
  • 25 (a)
CG8560 36
  • 32 (a)
CG8562 36
  • 29 (a)
CG8563 36
  • 32 (a)
CG8564 36
  • 17 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000621 35
  • 48.88 (n)
  • 39.95 (a)
(Caenorhabditis elegans)
Secernentea R11A5.7 37
  • 31 (a)
T06A4.3 37
  • 30 (a)
W01A8.6 37
  • 31 (a)
Y18H1A.9 37
  • 35 (a)
Y47G6A.19 37
  • 33 (a)
Y59C2A.1 37
  • 32 (a)
ZC434.9 37
  • 31 (a)
F02D8.4 36
  • 28 (a)
suro-1 36
  • 21 (a)
T06A4.1 36
  • 25 (a)
T06A4.3 36
  • 27 (a)
W01A8.6 36
  • 28 (a)
Y18H1A.9 36
  • 31 (a)
Y47G6A.19 36
  • 29 (a)
ZC434.9 36
  • 19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM14 36
  • 28 (a)
ECM14 38
bread mold
(Neurospora crassa)
Ascomycetes NCU07536 35
  • 49.34 (n)
  • 39.16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
-- 36
  • 39 (a)
CSA.11311 36
  • 38 (a)
CSA.4005 36
  • 20 (a)
Species with no ortholog for CPA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CPA4 Gene

Gene Tree for CPA4 (if available)
Gene Tree for CPA4 (if available)

Paralogs for CPA4 Gene

Paralogs for CPA4 Gene

(9) SIMAP similar genes for CPA4 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CPA4: view

Variants for CPA4 Gene

Sequence variations from dbSNP and Humsavar for CPA4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs729167 -- 130,311,268(+) CACTG(C/T)TTGCC intron-variant
rs901798 -- 130,291,174(+) CTATG(A/G)TCGCA upstream-variant-2KB
rs901799 -- 130,291,562(+) CAGTT(G/T)AAGTG upstream-variant-2KB
rs901800 -- 130,311,039(+) CTGGC(A/G)CTGCT intron-variant
rs1038627 -- 130,305,154(+) ACACC(A/G)ATGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPA4 Gene

Variant ID Type Subtype PubMed ID
esv272094 CNV Insertion 20981092

Variation tolerance for CPA4 Gene

Residual Variation Intolerance Score: 85.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.46; 97.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPA4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPA4 Gene

Disorders for CPA4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CPA4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
silver-russell syndrome
  • silver russell dwarfism
  • glioblastoma with sarcomatous component
- elite association
Search CPA4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CPA4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CPA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPA4 Gene

Publications for CPA4 Gene

  1. Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing. (PMID: 20385563) Tanco S. … Fricker L.D. (J. Biol. Chem. 2010) 23 67
  2. Carboxypeptidase 4 gene variants and early-onset intermediate-to-high risk prostate cancer. (PMID: 19245716) Ross P.L. … Witte J.S. (BMC Cancer 2009) 23 67
  3. Caught after the Act: a human A-type metallocarboxypeptidase in a product complex with a cleaved hexapeptide. (PMID: 17506531) BayAcs A. … Gomis-RA1th F.X. (Biochemistry 2007) 23 67
  4. Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking. (PMID: 16249216) Mouradov D. … Huber T. (Protein Eng. Des. Sel. 2006) 23 67
  5. Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin. (PMID: 15738388) Pallares I. … Gomis-Rueth F.-X. (Proc. Natl. Acad. Sci. U.S.A. 2005) 23 67

Products for CPA4 Gene

Sources for CPA4 Gene

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