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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPA4 Gene

protein-coding   GIFtS: 61
GCID: GC07P129932

Carboxypeptidase A4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carboxypeptidase A41 2
Carboxypeptidase A31 2 3
CPA32 3 5
EC 3.4.17.-3
EC 3.4.178
EC 3.4.17.18

External Ids:    HGNC: 157401   Entrez Gene: 512002   Ensembl: ENSG000001285107   OMIM: 6076355   UniProtKB: Q9UI423   

Export aliases for CPA4 gene to outside databases

Previous GC identifers: GC07P128409 GC07P129472 GC07P129485 GC07P129526 GC07P129720 GC07P124295


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CPA4 Gene:
This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other
family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of
carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This
gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate
gene for prostate cancer aggressiveness. (provided by RefSeq, Jul 2008)

GeneCards Summary for CPA4 Gene: 
CPA4 (carboxypeptidase A4) is a protein-coding gene. Diseases associated with CPA4 include silver-russell syndrome, and gliosarcoma. GO annotations related to this gene include metallocarboxypeptidase activity and zinc ion binding. An important paralog of this gene is CPO.

UniProtKB/Swiss-Prot: CBPA4_HUMAN, Q9UI42
Function: Metalloprotease that could be involved in the histone hyperacetylation pathway

Gene Wiki entry for CPA4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPA4 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   LCR-F1   E2F-1   E2F   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPA4 promoter sequence
   Search SABiosciences Chromatin IP Primers for CPA4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32   Ensembl cytogenetic band:  7q32.2   HGNC cytogenetic band: 7q32

CPA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPA4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P129932:  view genomic region     (about GC identifiers)

Start:
129,932,974 bp from pter      End:
129,964,020 bp from pter
Size:
31,047 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 129,318,357-129,349,405     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CBPA4_HUMAN, Q9UI42 (See protein sequence)
Recommended Name: Carboxypeptidase A4 precursor  
Size: 421 amino acids; 47351 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Interacts with LXN
Subcellular location: Secreted (By similarity)
4 PDB 3D structures from and Proteopedia for CPA4:
2BO9 (3D)        2BOA (3D)        2PCU (3D)        4A94 (3D)    
Secondary accessions: B7Z576 Q86UY9
Alternative splicing: 2 isoforms:  Q9UI42-1   Q9UI42-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CPA4: NX_Q9UI42

Explore proteomics data for CPA4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UI42

  • 4/6 DME Specific Peptides for CPA4 (Q9UI42) (see all 6)
     PTAEETW  FELRDTG  GIHSREW  HSYSQLL 

    CPA4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CPA4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001156918.1  NP_057436.2  

    ENSEMBL proteins: 
     ENSP00000222482   ENSP00000419455   ENSP00000417255   ENSP00000418392   ENSP00000419660  
     ENSP00000418276   ENSP00000412947  

    Human Recombinant Protein Products for CPA4: 
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    Novus Biologicals CPA4 Protein
    Novus Biologicals CPA4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CPA4 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--

    CPA4 for ontologies           About GeneDecksing



    CPA4 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: Carboxypeptidase A4 
    Metallocarboxypeptidases

    3 InterPro protein domains:
     IPR003146 Prot_inh_M14A
     IPR000834 Peptidase_M14
     IPR009020 Prot_inh_propept

    Graphical View of Domain Structure for InterPro Entry Q9UI42

    ProtoNet protein and cluster: Q9UI42

    2 Blocks protein domains:
    IPB000834 Zinc carboxypeptidase A metalloprotease (M14)
    IPB003146 Carboxypeptidase activation peptide


    UniProtKB/Swiss-Prot: CBPA4_HUMAN, Q9UI42
    Similarity: Belongs to the peptidase M14 family


    CPA4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBPA4_HUMAN, Q9UI42
    Function: Metalloprotease that could be involved in the histone hyperacetylation pathway
    Induction: Up-regulated by inhibitors of histone dacetylation

         Enzyme Numbers (IUBMB): EC 3.4.172 EC 3.4.17.-1 EC 3.4.17.12

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004180carboxypeptidase activity ----
    GO:0004181metallocarboxypeptidase activity NAS10383164
    GO:0008270zinc ion binding IEA--
         
    CPA4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CPA4:
     Decreased viability 

         1 MGI phenotypic allele for Cpa4 (no phenotypes)

    CPA4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cpa4tm1Lex for CPA4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CPA4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CPA4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPA4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPA4 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPA4
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate CPA4 (see all 29):
    hsa-miR-34b* hsa-miR-362-3p hsa-let-7d hsa-miR-3616-5p hsa-miR-202 hsa-let-7c hsa-miR-3190 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidCPA4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CPA4
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    Gene Editing
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                         Customized lentivirus expression plasmids for stable overexpression of CPA4 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPA4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPA4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/7 Interacting proteins for CPA4 (Q9UI423 ENSP000002224824) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LXNQ9BS403, ENSP000002642654I2D: score=2 STRING: ENSP00000264265
    ATP6V0D1P614213I2D: score=5 
    GPX4P369693I2D: score=1 
    KAT5Q929933I2D: score=1 
    PRKAB1Q9Y4783I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis NAS--
    GO:0016573histone acetylation NAS10383164

    CPA4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CPA4 (CBPA4)

    Search CenterWatch for drugs/clinical trials and news about CPA4 / CBPA4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CPA4 gene (2 alternative transcripts): 
    NM_001163446.1  NM_016352.3  

    Unigene Cluster for CPA4:

    Carboxypeptidase A4
    Hs.93764  [show with all ESTs]
    Unigene Representative Sequence: NM_016352
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222482(uc003vpr.3 uc011kpe.2) ENST00000497388 ENST00000470542
    ENST00000474254 ENST00000492072 ENST00000490117 ENST00000473956 ENST00000493259
    ENST00000486598 ENST00000488025 ENST00000445470(uc011kpd.2)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPA4
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate CPA4 (see all 29):
    hsa-miR-34b* hsa-miR-362-3p hsa-let-7d hsa-miR-3616-5p hsa-miR-202 hsa-let-7c hsa-miR-3190 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidCPA4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CPA4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPA4
    Clone
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    OriGene clones in human, mouse for CPA4 (see all 13)
    OriGene ORF clones in mouse, rat for CPA4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CPA4 (NM_016352)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPA4
    Sirion Biotech Customized lentivirus for stable overexpression of CPA4 
                         Customized lentivirus expression plasmids for stable overexpression of CPA4 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CPA4
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPA4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPA4

    Additional mRNA sequence: 

    AF095719.1 AK290993.1 AK298550.1 AK298553.1 AK299023.1 AK310933.1 AY358699.1 BC052289.1 

    2 DOTS entries:

    DT.97841387  DT.121077055 

    24/58 AceView cDNA sequences (see all 58):

    CN483165 CN483227 BM739740 BU183339 BE378215 BM756444 AY358699 BM739971 
    BM738894 AU280759 BM744173 BX344093 BE156038 BE156046 BM739962 BG750409 
    BM739012 BM739050 BM747861 BM739049 BM739061 AW606336 BC052289 BM747422 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CPA4 expression in normal human tissues (normalized intensities)      CPA4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CPA4 Expression
    About this image


    CPA4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Human Umbillical Artery Smooth Muscle Cells (HUASMC)   
     
     Epithelium
             Human Iris Pigment Epithelial Cells (HIPEpiC)   
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem Progenitor ES-263
     
     Fibroblast (Uncategorized)    fully expand to see all 2 entries
             Human Ovarian Fibroblasts (HOF)   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Human Pulmonary Artery Smooth Muscle Cells (HPASMC)   

    See CPA4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CPA4

    SOURCE GeneReport for Unigene cluster: Hs.93764

    UniProtKB/Swiss-Prot: CBPA4_HUMAN, Q9UI42
    Tissue specificity: Fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver and lung. Except
    for fetal brain that shows no imprinting, expression was found preferentially from the maternal allele

        SABiosciences Custom PCR Arrays for CPA4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPA4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CPA4 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpa41 , 5 carboxypeptidase A41, 5 85.08(n)1
    84.05(a)1
      6 (12.52 cM)5
    717911  NM_027926.21  NP_082202.11 
     305683695 
    chicken
    (Gallus gallus)
    Aves CPA26
    Uncharacterized protein
    60(a)
    1 → many
    1(902989-909381)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    58(a)
    1 → many
    GL343819.1(99048-121685)
    zebrafish
    (Danio rerio)
    Actinopterygii cpa46
    cpa26
    carboxypeptidase A2 (pancreatic)
    57(a)
    51(a)
    many ↔ many
    many ↔ many
    25(16939228-16946517)
    25(16947692-16957867)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG31081 , 3 metallocarboxypeptidase3
    CG31081
    37(a)
    (best of 18)3
    50.23(n)1
    39.02(a)1
      5C23
    315061  NM_132034.11  NP_572262.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y18H1A.93   -- 35(a)
    (best of 7)
      I(748486-756927)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ECM14(YHR132C)4 Putative metalloprotease with similarity to the zinc more   --   8(369794-368502) 856533  NP_012000.1 


    ENSEMBL Gene Tree for CPA4 (if available)
    TreeFam Gene Tree for CPA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CPA4 gene
    CPO2  CPA22  CPA12  CPA62  CPB12  CPA32  CPA52  CPB22  
    9 SIMAP similar genes for CPA4 using alignment to 7 protein entries:     CBPA4_HUMAN (see all proteins):
    CPA1    DKFZp779K1333    CPA5    CPA2    CPO    CPA6
    CPA3    CPB1    CPB2

    CPA4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/778 SNPs in CPA4 are shown (see all 778)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2017070361,2
    --129316452(+) AAAAA-/ACAAACA 2 -- us2k10--------
    rs113479401,2
    C--129328486(+) CGAACT/-TTTTT 2 -- int1 trp32Minor allele frequency- -:0.25NA CSA 4
    rs58874671,2
    C,F--129931062(+) GTCTCA/-AAAAA 2 -- us2k1 tfbs33Minor allele frequency- -:0.50NA CSA 6
    rs711785711,2
    C--129932081(-) ATCTCAAAT/-  
            
    AAATA
    2 -- us2k11Minor allele frequency- -:0.00NA 2
    rs670859551,2
    C--129936533(+) TTTTT-/TTT   
      
    /TTTTT
    TTTTT
    4 -- int1 cds11NA 2
    rs724069041,2
    C--129947082(+) GATAG-/AAAAAA 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs562873151,2
    C--129947095(+) AAAAA-/ACCCTA 2 -- int10--------
    rs615285471,2
    C--129950074(+) TTCAT-/ACACACA 2 -- int10--------
    rs1407189451,2
    C--129951774(+) GGGGG-/GCTGAG 2 -- int10--------
    rs558115031,2
    C--129955271(+) TTTTTT/-AGAAT 2 -- int11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for CPA4 (129932974 - 129964020 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CPA4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv272094CNV Insertion20981092


    Human Gene Mutation Database (HGMD): CPA4
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607635    OMIM disorders: --

    5 diseases for CPA4:    About MalaCards
    silver-russell syndrome    gliosarcoma    prostate cancer    prostatitis
    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for CPA4:
    Silver-Russell syndrome

    CPA4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CPA4
    Human Genome Epidemiology (HuGE) Navigator: CPA4 (3 documents)

    Export disorders for CPA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CPA4 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with CPA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells. (PubMed id 10383164)1, 2, 3 Huang H.... Smith D.I. (1999)
    2. Carboxypeptidase 4 gene variants and early-onset intermediate-to-high risk prostate cancer. (PubMed id 19245716)1, 4, 9 Ross P.L....Witte J.S. (2009)
    3. Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin. (PubMed id 15738388)1, 2, 9 Pallares I.... Gomis-Rueth F.-X. (2005)
    4. Detailed molecular comparison between the inhibition mode of A/B-type carboxypeptidases in the zymogen state and by the endogenous inhibitor latexin. (PubMed id 16091843)1, 2 Garcia-Castellanos R.... Gomis-Rueth F.-X. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. The novel imprinted carboxypeptidase A4 gene (CPA4) in the 7q32 imprinting domain. (PubMed id 12552318)1, 2 Kayashima T.... Kishino T. (2003)
    8. Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32. (PubMed id 10860668)1, 3 Hayashida S....Kishino T. (2000)
    9. Characterization of the substrate specificity of huma n carboxypeptidase A4 and implications for a role in extracellular peptide proc essing. (PubMed id 20385563)1, 9 Tanco S....Fricker L.D. (2010)
    10. Crystal structure of novel metallocarboxypeptidase inh ibitor from marine mollusk Nerita versicolor in complex with human carboxypeptid ase A4. (PubMed id 22294694)1 Covaleda G....Reverter D. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51200 HGNC: 15740 AceView: CPA4 Ensembl:ENSG00000128510 euGenes: HUgn51200
    ECgene: CPA4 H-InvDB: CPA4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CPA4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CPA4 gene:
    Search GeneIP for patents involving CPA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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