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Aliases for CPA4 Gene

Aliases for CPA4 Gene

  • Carboxypeptidase A4 2 3
  • Carboxypeptidase A3 2 3 4
  • CPA3 3 4 6
  • EC 3.4.17.1 64
  • EC 3.4.17.- 4
  • EC 3.4.17 64

External Ids for CPA4 Gene

Summaries for CPA4 Gene

Entrez Gene Summary for CPA4 Gene

  • This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness. [provided by RefSeq, Jul 2008]

GeneCards Summary for CPA4 Gene

CPA4 (Carboxypeptidase A4) is a Protein Coding gene. Diseases associated with CPA4 include prostate cancer and richters syndrome. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Pancreatic secretion. GO annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPA3.

UniProtKB/Swiss-Prot for CPA4 Gene

  • Metalloprotease that could be involved in the histone hyperacetylation pathway.

Gene Wiki entry for CPA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPA4 Gene

Genomics for CPA4 Gene

Genomic Location for CPA4 Gene

Start:
130,293,134 bp from pter
End:
130,324,180 bp from pter
Size:
31,047 bases
Orientation:
Plus strand

Genomic View for CPA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPA4 Gene

Regulatory Elements for CPA4 Gene

Proteins for CPA4 Gene

  • Protein details for CPA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UI42-CBPA4_HUMAN
    Recommended name:
    Carboxypeptidase A4
    Protein Accession:
    Q9UI42
    Secondary Accessions:
    • B7Z576
    • Q86UY9

    Protein attributes for CPA4 Gene

    Size:
    421 amino acids
    Molecular mass:
    47351 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Monomer. Interacts with LXN.

    Three dimensional structures from OCA and Proteopedia for CPA4 Gene

    Alternative splice isoforms for CPA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CPA4 Gene

Proteomics data for CPA4 Gene at MOPED

Selected DME Specific Peptides for CPA4 Gene

Post-translational modifications for CPA4 Gene

Other Protein References for CPA4 Gene

Domains for CPA4 Gene

Gene Families for CPA4 Gene

UniProtKB/Swiss-Prot:

CBPA4_HUMAN
Family:
  • Belongs to the peptidase M14 family.:
    • Q9UI42
genes like me logo Genes that share domains with CPA4: view

Function for CPA4 Gene

Molecular function for CPA4 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=55.6 uM for 3-(2-furyl)acryloyl-Phe-Phe {ECO:0000269 PubMed:20385563}; KM=19.4 uM for 3-(2-furyl)acryloyl-Phe-Leu {ECO:0000269 PubMed:20385563}; KM=23.3 uM for 3-(2-furyl)acryloyl-Phe-Ile {ECO:0000269 PubMed:20385563}; KM=40.4 uM for 3-(2-furyl)acryloyl-Phe-Met {ECO:0000269 PubMed:20385563}; KM=57.3 uM for 3-(2-furyl)acryloyl-Phe-Val {ECO:0000269 PubMed:20385563}; KM=0.329 uM for neurotensin {ECO:0000269 PubMed:20385563}; KM=9.23 uM for Met-enkephalin-Arg-Phe {ECO:0000269 PubMed:20385563}; pH dependence: Optimum pH is 8.5-9. {ECO:0000269 PubMed:20385563};
UniProtKB/Swiss-Prot CatalyticActivity: Release of a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by interaction with the metallocarboxypeptidase inhibitor (MCPI) from N.versicolor that binds to the catalytic zinc ion.
UniProtKB/Swiss-Prot Function: Metalloprotease that could be involved in the histone hyperacetylation pathway.
UniProtKB/Swiss-Prot Induction: Up-regulated by inhibitors of histone dacetylation.

Enzyme Numbers (IUBMB) for CPA4 Gene

Gene Ontology (GO) - Molecular Function for CPA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity --
GO:0004181 metallocarboxypeptidase activity NAS 10383164
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CPA4: view

Phenotypes for CPA4 Gene

GenomeRNAi human phenotypes for CPA4:
genes like me logo Genes that share phenotypes with CPA4: view

miRNA for CPA4 Gene

miRTarBase miRNAs that target CPA4

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CPA4 Gene

Localization for CPA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPA4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPA4 Gene COMPARTMENTS Subcellular localization image for CPA4 gene
Compartment Confidence
extracellular 3
cytoskeleton 1
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CPA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CPA4: view

Pathways for CPA4 Gene

genes like me logo Genes that share pathways with CPA4: view

Gene Ontology (GO) - Biological Process for CPA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0016573 histone acetylation NAS 10383164
genes like me logo Genes that share ontologies with CPA4: view

Transcripts for CPA4 Gene

Unigene Clusters for CPA4 Gene

Carboxypeptidase A4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPA4 Gene

No ASD Table

Relevant External Links for CPA4 Gene

GeneLoc Exon Structure for
CPA4
ECgene alternative splicing isoforms for
CPA4

Expression for CPA4 Gene

mRNA expression in normal human tissues for CPA4 Gene

mRNA differential expression in normal tissues according to GTEx for CPA4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (11.0), Skin - Sun Exposed (Lower leg) (9.1), Esophagus - Mucosa (7.1), Minor Salivary Gland (5.9), and Cervix - Ectocervix (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CPA4 Gene

SOURCE GeneReport for Unigene cluster for CPA4 Gene Hs.93764

mRNA Expression by UniProt/SwissProt for CPA4 Gene

Q9UI42-CBPA4_HUMAN
Tissue specificity: Fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver and lung. Except for fetal brain that shows no imprinting, expression was found preferentially from the maternal allele
genes like me logo Genes that share expressions with CPA4: view

Orthologs for CPA4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CPA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPA4 36
  • 99.13 (n)
  • 98.81 (a)
CPA4 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPA4 36
  • 81.27 (n)
  • 71.67 (a)
CPA4 37
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPA4 36
  • 89.15 (n)
  • 88.84 (a)
CPA4 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpa4 36
  • 85.08 (n)
  • 84.05 (a)
Cpa4 16
Cpa4 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPA4 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 73 (a)
OneToMany
-- 37
  • 50 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cpa4 36
  • 84.92 (n)
  • 84.76 (a)
chicken
(Gallus gallus)
Aves CPA2 37
  • 60 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 59 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii cpa2 37
  • 51 (a)
ManyToMany
cpa4 37
  • 57 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000621 36
  • 48.88 (n)
  • 39.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12374 37
  • 28 (a)
ManyToMany
CG14820 37
  • 30 (a)
ManyToMany
CG17633 37
  • 30 (a)
ManyToMany
CG18417 37
  • 29 (a)
ManyToMany
CG18585 37
  • 30 (a)
ManyToMany
CG2915 37
  • 26 (a)
ManyToMany
CG3108 36
  • 50.36 (n)
  • 39.07 (a)
CG32379 37
  • 29 (a)
ManyToMany
CG4017 37
  • 33 (a)
ManyToMany
CG4408 37
  • 26 (a)
ManyToMany
CG7025 37
  • 31 (a)
ManyToMany
CG8539 37
  • 25 (a)
ManyToMany
CG8560 37
  • 32 (a)
ManyToMany
CG8562 37
  • 29 (a)
ManyToMany
CG8563 37
  • 32 (a)
ManyToMany
CG8564 37
  • 17 (a)
ManyToMany
CG3097 38
  • 35 (a)
CG8563 38
  • 33 (a)
CG8539 38
  • 30 (a)
CG3108 38
  • 37 (a)
CG8560 38
  • 33 (a)
CG18585 38
  • 31 (a)
CG15769 38
  • 26 (a)
CG14820 38
  • 30 (a)
CG18415 38
  • 30 (a)
CG17633 38
  • 33 (a)
CG8945 38
  • 26 (a)
CG8562 38
  • 29 (a)
CG2915 38
  • 28 (a)
CG12374 38
  • 30 (a)
CG4408 38
  • 31 (a)
CG4017 38
  • 35 (a)
CG7025 38
  • 36 (a)
CG18417 38
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea F02D8.4 37
  • 28 (a)
ManyToMany
suro-1 37
  • 21 (a)
ManyToMany
T06A4.1 37
  • 25 (a)
ManyToMany
T06A4.3 37
  • 27 (a)
ManyToMany
W01A8.6 37
  • 28 (a)
ManyToMany
Y18H1A.9 37
  • 31 (a)
ManyToMany
Y47G6A.19 37
  • 29 (a)
ManyToMany
ZC434.9 37
  • 19 (a)
ManyToMany
R11A5.7 38
  • 31 (a)
Y18H1A.9 38
  • 35 (a)
T06A4.3 38
  • 30 (a)
Y59C2A.1 38
  • 32 (a)
ZC434.9 38
  • 31 (a)
Y47G6A.19 38
  • 33 (a)
W01A8.6 38
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM14 37
  • 28 (a)
OneToMany
ECM14 39
bread mold
(Neurospora crassa)
Ascomycetes NCU07536 36
  • 49.34 (n)
  • 39.16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
ManyToMany
-- 37
  • 39 (a)
ManyToMany
CSA.11311 37
  • 38 (a)
ManyToMany
CSA.4005 37
  • 20 (a)
ManyToMany
Species with no ortholog for CPA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CPA4 Gene

ENSEMBL:
Gene Tree for CPA4 (if available)
TreeFam:
Gene Tree for CPA4 (if available)

Paralogs for CPA4 Gene

Paralogs for CPA4 Gene

Selected SIMAP similar genes for CPA4 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CPA4: view

Variants for CPA4 Gene

Sequence variations from dbSNP and Humsavar for CPA4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs729167 -- 130,311,268(+) CACTG(C/T)TTGCC intron-variant
rs737344 -- 130,321,102(-) tcctc(A/C)cacct intron-variant
rs901798 -- 130,291,174(+) CTATG(A/G)TCGCA upstream-variant-2KB
rs901799 -- 130,291,562(+) CAGTT(G/T)AAGTG upstream-variant-2KB
rs901800 -- 130,311,039(+) CTGGC(A/G)CTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPA4 Gene

Variant ID Type Subtype PubMed ID
esv272094 CNV Insertion 20981092

Relevant External Links for CPA4 Gene

HapMap Linkage Disequilibrium report
CPA4
Human Gene Mutation Database (HGMD)
CPA4

Disorders for CPA4 Gene

(1) University of Copenhagen DISEASES for CPA4 Gene

Relevant External Links for CPA4

Genetic Association Database (GAD)
CPA4
Human Genome Epidemiology (HuGE) Navigator
CPA4
genes like me logo Genes that share disorders with CPA4: view

No data available for UniProtKB/Swiss-Prot for CPA4 Gene

Publications for CPA4 Gene

  1. Carboxypeptidase 4 gene variants and early-onset intermediate-to-high risk prostate cancer. (PMID: 19245716) Ross P.L. … Witte J.S. (BMC Cancer 2009) 3 23 49
  2. Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing. (PMID: 20385563) Tanco S. … Fricker L.D. (J. Biol. Chem. 2010) 3 4 23
  3. Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells. (PMID: 10383164) Huang H. … Smith D.I. (Cancer Res. 1999) 2 3 4
  4. Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin. (PMID: 15738388) Pallares I. … Gomis-Rueth F.-X. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 23
  5. The novel imprinted carboxypeptidase A4 gene (CPA4) in the 7q32 imprinting domain. (PMID: 12552318) Kayashima T. … Kishino T. (Hum. Genet. 2003) 3 4

Products for CPA4 Gene

Sources for CPA4 Gene

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