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CPA4 Gene

protein-coding   GIFtS: 61
GCID: GC07P129932

Carboxypeptidase A4

  See CPA4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carboxypeptidase A41 2
Carboxypeptidase A31 2 3
CPA32 3 5
EC 3.4.17.-3
EC 3.4.178
EC 3.4.17.18

External Ids:    HGNC: 157401   Entrez Gene: 512002   Ensembl: ENSG000001285107   OMIM: 6076355   UniProtKB: Q9UI423   

Export aliases for CPA4 gene to outside databases

Previous GC identifers: GC07P128409 GC07P129472 GC07P129485 GC07P129526 GC07P129720 GC07P124295


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CPA4 Gene:
This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other
family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of
carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This
gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate
gene for prostate cancer aggressiveness. (provided by RefSeq, Jul 2008)

GeneCards Summary for CPA4 Gene:
CPA4 (carboxypeptidase A4) is a protein-coding gene. Diseases associated with CPA4 include richter's syndrome, and silver-russell syndrome. GO annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPO.

UniProtKB/Swiss-Prot: CBPA4_HUMAN, Q9UI42
Function: Metalloprotease that could be involved in the histone hyperacetylation pathway

Gene Wiki entry for CPA4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CPA4 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   LCR-F1   E2F-1   E2F   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCPA4 promoter sequence
   Search Chromatin IP Primers for CPA4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32   Ensembl cytogenetic band:  7q32.2   HGNC cytogenetic band: 7q32

CPA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPA4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P129932:  view genomic region     (about GC identifiers)

Start:
129,932,974 bp from pter      End:
129,964,020 bp from pter
Size:
31,047 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 129,318,357-129,349,405     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CBPA4_HUMAN, Q9UI42 (See protein sequence)
Recommended Name: Carboxypeptidase A4 precursor  
Size: 421 amino acids; 47351 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Monomer. Interacts with LXN
5 PDB 3D structures from and Proteopedia for CPA4:
2BO9 (3D)        2BOA (3D)        2PCU (3D)        4A94 (3D)        4BD9 (3D)    
Secondary accessions: B7Z576 Q86UY9
Alternative splicing: 2 isoforms:  Q9UI42-1   Q9UI42-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CPA4: NX_Q9UI42

Explore proteomics data for CPA4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn260
  • Selected DME Specific Peptides for CPA4 (Q9UI42) (see all 6)
     PTAEETW  FELRDTG  GIHSREW  HSYSQLL 


    See CPA4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001156918.1  NP_057436.2  

    ENSEMBL proteins: 
     ENSP00000222482   ENSP00000419455   ENSP00000417255   ENSP00000418392   ENSP00000419660  
     ENSP00000418276   ENSP00000412947  

    CPA4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CPA4

     
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    antibodies-online proteins for CPA4 (6 products) 

     
    antibodies-online peptides for CPA4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Carboxypeptidase A4
    Metallocarboxypeptidases

    3 InterPro protein domains:
     IPR003146 Prot_inh_M14A
     IPR000834 Peptidase_M14
     IPR009020 Prot_inh_propept

    Graphical View of Domain Structure for InterPro Entry Q9UI42

    ProtoNet protein and cluster: Q9UI42

    2 Blocks protein domains:
    IPB000834 Zinc carboxypeptidase A metalloprotease (M14)
    IPB003146 Carboxypeptidase activation peptide


    UniProtKB/Swiss-Prot: CBPA4_HUMAN, Q9UI42
    Similarity: Belongs to the peptidase M14 family


    Find genes that share domains with CPA4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBPA4_HUMAN, Q9UI42
    Function: Metalloprotease that could be involved in the histone hyperacetylation pathway
    Enzyme regulation: Inhibited by interaction with the metallocarboxypeptidase inhibitor (MCPI) from N.versicolor
    that binds to the catalytic zinc ion
    Induction: Up-regulated by inhibitors of histone dacetylation

         Enzyme Numbers (IUBMB): EC 3.4.172 EC 3.4.17.-1 EC 3.4.17.12

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004180carboxypeptidase activity ----
    GO:0004181metallocarboxypeptidase activity NAS10383164
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with CPA4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CPA4:
     Decreased viability 

         1 MGI phenotypic allele for Cpa4 (no phenotypes)

    Find genes that share phenotypes with CPA4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cpa4tm1Lex for CPA4

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    hsa-mir-98-5p (MIRT027514), hsa-mir-26b-5p (MIRT029046)

    Block miRNA regulation of human, mouse, rat CPA4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CPA4 (see all 29):
    hsa-miR-34b* hsa-miR-362-3p hsa-let-7d hsa-miR-3616-5p hsa-miR-202 hsa-let-7c hsa-miR-3190 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidCPA4 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CBPA4_HUMAN, Q9UI42: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    cytoskeleton1
    cytosol1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with CPA4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CPA4
    Interactions:

        Search GeneGlobe Interaction Network for CPA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for CPA4 (Q9UI423 ENSP000002224824) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LXNQ9BS403, ENSP000002642654I2D: score=2 STRING: ENSP00000264265
    ATP6V0D1P614213I2D: score=5 
    GPX4P369693I2D: score=1 
    KAT5Q929933I2D: score=1 
    PRKAB1Q9Y4783I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0016573histone acetylation NAS10383164

    Find genes that share ontologies with CPA4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CPA4 (CBPA4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CPA4 gene (2 alternative transcripts): 
    NM_001163446.1  NM_016352.3  

    Unigene Cluster for CPA4:

    Carboxypeptidase A4
    Hs.93764  [show with all ESTs]
    Unigene Representative Sequence: NM_016352
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222482(uc003vpr.3 uc011kpe.2) ENST00000497388 ENST00000470542
    ENST00000474254 ENST00000492072 ENST00000490117 ENST00000473956 ENST00000493259
    ENST00000486598 ENST00000488025 ENST00000445470(uc011kpd.2)
    miRNA
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    hsa-miR-34b* hsa-miR-362-3p hsa-let-7d hsa-miR-3616-5p hsa-miR-202 hsa-let-7c hsa-miR-3190 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidCPA4 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat CPA4

    Additional mRNA sequence: 

    AF095719.1 AK290993.1 AK298550.1 AK298553.1 AK299023.1 AK310933.1 AY358699.1 BC052289.1 

    2 DOTS entries:

    DT.97841387  DT.121077055 

    Selected AceView cDNA sequences (see all 58):

    CN483165 CN483227 BM739971 AU280759 BM739061 BC052289 BM747861 BU183339 
    BQ953478 BM760081 BQ773508 BM739049 BM760178 BE156046 BE378215 BM752091 
    BG750409 BM744173 BM739050 AW606336 BM756444 BE156038 BX344093 BM739962 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CPA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CPA4 Expression
    About this image

    CPA4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CPA4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.93764

    UniProtKB/Swiss-Prot: CBPA4_HUMAN, Q9UI42
    Tissue specificity: Fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver and lung. Except
    for fetal brain that shows no imprinting, expression was found preferentially from the maternal allele

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CPA4 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpa41 , 5 carboxypeptidase A41, 5 85.08(n)1
    84.05(a)1
      6 (12.52 cM)5
    717911  NM_027926.21  NP_082202.11 
     305683695 
    chicken
    (Gallus gallus)
    Aves CPA26
    Gallus gallus carboxypeptidase A2 (pancreatic) (CP...
    60(a)
    1 → many
    1(902989-909381)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    59(a)
    1 → many
    GL343819.1(99048-121685)
    zebrafish
    (Danio rerio)
    Actinopterygii cpa46
    cpa26
    carboxypeptidase A2 (pancreatic)
    57(a)
    51(a)
    many ↔ many
    many ↔ many
    25(16939228-16946517) ENSDARG00000043722
    25(16947692-16957867) ENSDARG00000010146
    fruit fly
    (Drosophila melanogaster)
    Insecta CG31081 , 3 metallocarboxypeptidase3
    CG31081
    37(a)
    (best of 18)3
    50.36(n)1
    39.07(a)1
      5C23
    315061  NM_132034.11  NP_572262.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y18H1A.93   -- 35(a)
    (best of 7)
      I(748486-756927)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ECM14(YHR132C)4 Putative metalloprotease with similarity to the zinc more   --   8(369794-368502) 856533  NP_012000.1 


    ENSEMBL Gene Tree for CPA4 (if available)
    TreeFam Gene Tree for CPA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CPA4 gene
    CPO2  CPA22  CPA12  CPB12  CPA62  CPA32  CPA52  CPB22  
    9 SIMAP similar genes for CPA4 using alignment to 7 protein entries:     CBPA4_HUMAN (see all proteins):
    CPA1    DKFZp779K1333    CPA5    CPA2    CPO    CPA6
    CPA3    CPB1    CPB2

    Find genes that share paralogs with CPA4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CPA4 (see all 778)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2017070361,2
    --129316452(+) AAAAA-/ACAAACA 2 -- us2k10--------
    rs113479401,2
    C--129328486(+) CGAACT/-TTTTT 2 -- int1 trp32Minor allele frequency- -:0.25NA CSA 4
    rs58874671,2
    C,F--129931062(+) GTCTCA/-AAAAA 2 -- us2k1 tfbs33Minor allele frequency- -:0.50NA CSA 6
    rs711785711,2
    C--129932081(-) ATCTCAAAT/-  
            
    AAATA
    2 -- us2k11Minor allele frequency- -:0.00NA 2
    rs670859551,2
    C--129936533(+) TTTTT-/TTT   
      
    /TTTTT
    TTTTT
    4 -- int1 cds11NA 2
    rs724069041,2
    C--129947082(+) GATAG-/AAAAAA 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs562873151,2
    C--129947095(+) AAAAA-/ACCCTA 2 -- int10--------
    rs615285471,2
    C--129950074(+) TTCAT-/ACACACA 2 -- int10--------
    rs1407189451,2
    C--129951774(+) GGGGG-/GCTGAG 2 -- int10--------
    rs558115031,2
    C--129955271(+) TTTTTT/-AGAAT 2 -- int11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for CPA4 (129932974 - 129964020 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CPA4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv272094CNV Insertion20981092

    Human Gene Mutation Database (HGMD): CPA4
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607635    OMIM disorders: --

    3 diseases for CPA4:    
    About MalaCards
    richter's syndrome    silver-russell syndrome    prostate cancer

    1 disease from the University of Copenhagen DISEASES database for CPA4:
    Silver-Russell syndrome

    Find genes that share disorders with CPA4           About GenesLikeMe

    Genetic Association Database (GAD): CPA4
    Human Genome Epidemiology (HuGE) Navigator: CPA4 (3 documents)

    Export disorders for CPA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CPA4 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with CPA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells. (PubMed id 10383164)1, 2, 3 Huang H.... Smith D.I. (Cancer Res. 1999)
    2. Carboxypeptidase 4 gene variants and early-onset intermediate-to-high risk prostate cancer. (PubMed id 19245716)1, 4, 9 Ross P.L....Witte J.S. (BMC Cancer 2009)
    3. Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin. (PubMed id 15738388)1, 2, 9 Pallares I.... Gomis-Rueth F.-X. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    4. Crystal structure of novel metallocarboxypeptidase inhibitor from marine mollusk Nerita versicolor in complex with human carboxypeptidase A4. (PubMed id 22294694)1, 2 Covaleda G....Reverter D. (J. Biol. Chem. 2012)
    5. Detailed molecular comparison between the inhibition mode of A/B-type carboxypeptidases in the zymogen state and by the endogenous inhibitor latexin. (PubMed id 16091843)1, 2 Garcia-Castellanos R.... Gomis-Rueth F.-X. (Cell. Mol. Life Sci. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. The novel imprinted carboxypeptidase A4 gene (CPA4) in the 7q32 imprinting domain. (PubMed id 12552318)1, 2 Kayashima T.... Kishino T. (Hum. Genet. 2003)
    9. Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32. (PubMed id 10860668)1, 3 Hayashida S....Kishino T. (Genomics 2000)
    10. Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing. (PubMed id 20385563)1, 9 Tanco S....Fricker L.D. (J. Biol. Chem. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51200 HGNC: 15740 AceView: CPA4 Ensembl:ENSG00000128510 euGenes: HUgn51200
    ECgene: CPA4 H-InvDB: CPA4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CPA4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CPA4 gene:
    Search GeneIP for patents involving CPA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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