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Aliases for CPA2 Gene

Aliases for CPA2 Gene

  • Carboxypeptidase A2 (Pancreatic) 2 3
  • EC 3.4.17.15 4
  • EC 3.4.17 64

External Ids for CPA2 Gene

Summaries for CPA2 Gene

Entrez Gene Summary for CPA2 Gene

  • Three different forms of human pancreatic procarboxypeptidase A have been isolated. The encoded protein represents the A2 form, which is a monomeric protein with different biochemical properties from the A1 and A3 forms. The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues and is a secreted protein. [provided by RefSeq, Dec 2008]

GeneCards Summary for CPA2 Gene

CPA2 (Carboxypeptidase A2 (Pancreatic)) is a Protein Coding gene. Among its related pathways are Pancreatic secretion and Protein digestion and absorption. GO annotations related to this gene include metallocarboxypeptidase activity and carboxypeptidase activity. An important paralog of this gene is CPA3.

Gene Wiki entry for CPA2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPA2 Gene

Genomics for CPA2 Gene

Genomic Location for CPA2 Gene

Start:
130,266,827 bp from pter
End:
130,289,798 bp from pter
Size:
22,972 bases
Orientation:
Plus strand

Genomic View for CPA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPA2 Gene

Regulatory Elements for CPA2 Gene

Proteins for CPA2 Gene

  • Protein details for CPA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48052-CBPA2_HUMAN
    Recommended name:
    Carboxypeptidase A2
    Protein Accession:
    P48052
    Secondary Accessions:
    • A4D1M4
    • C9JIK1
    • Q53XS1
    • Q96A12
    • Q96QN3
    • Q9UCF1

    Protein attributes for CPA2 Gene

    Size:
    419 amino acids
    Molecular mass:
    47030 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA74425.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH07009.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH14571.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH15140.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAL24092.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CPA2 Gene

neXtProt entry for CPA2 Gene

Proteomics data for CPA2 Gene at MOPED

Selected DME Specific Peptides for CPA2 Gene

Post-translational modifications for CPA2 Gene

No Post-translational modifications

Other Protein References for CPA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for CPA2 Gene

Gene Families for CPA2 Gene

UniProtKB/Swiss-Prot:

CBPA2_HUMAN
Family:
  • Belongs to the peptidase M14 family.:
    • P48052
genes like me logo Genes that share domains with CPA2: view

Function for CPA2 Gene

Molecular function for CPA2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Similar to that of carboxypeptidase A (EC 3.4.17.1), but with a preference for bulkier C-terminal residues

Enzyme Numbers (IUBMB) for CPA2 Gene

Gene Ontology (GO) - Molecular Function for CPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity IDA 2920728
GO:0004181 metallocarboxypeptidase activity IDA 2920728
GO:0008270 zinc ion binding IDA 2920728
genes like me logo Genes that share ontologies with CPA2: view

Phenotypes for CPA2 Gene

genes like me logo Genes that share phenotypes with CPA2: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CPA2 Gene

Localization for CPA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPA2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPA2 Gene COMPARTMENTS Subcellular localization image for CPA2 gene
Compartment Confidence
extracellular 5
golgi apparatus 2
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 2920728
genes like me logo Genes that share ontologies with CPA2: view

Pathways for CPA2 Gene

genes like me logo Genes that share pathways with CPA2: view

Pathways by source for CPA2 Gene

Gene Ontology (GO) - Biological Process for CPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007039 protein catabolic process in the vacuole TAS 2920728
genes like me logo Genes that share ontologies with CPA2: view

Transcripts for CPA2 Gene

mRNA/cDNA for CPA2 Gene

Unigene Clusters for CPA2 Gene

Carboxypeptidase A2 (pancreatic):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPA2 Gene

No ASD Table

Relevant External Links for CPA2 Gene

GeneLoc Exon Structure for
CPA2
ECgene alternative splicing isoforms for
CPA2

Expression for CPA2 Gene

mRNA expression in normal human tissues for CPA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPA2 Gene

This gene is overexpressed in Pancreas (52.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CPA2 Gene

SOURCE GeneReport for Unigene cluster for CPA2 Gene Hs.490038

genes like me logo Genes that share expressions with CPA2: view

Orthologs for CPA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CPA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPA2 36
  • 99.68 (n)
  • 99.76 (a)
CPA2 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPA2 36
  • 89.29 (n)
  • 90.41 (a)
mouse
(Mus musculus)
Mammalia Cpa2 36
  • 85.53 (n)
  • 86.33 (a)
Cpa2 16
Cpa2 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 56 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 75 (a)
OneToMany
-- 37
  • 81 (a)
OneToMany
-- 37
  • 90 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cpa2 36
  • 85.61 (n)
  • 87.53 (a)
chicken
(Gallus gallus)
Aves CPA2 36
  • 72.26 (n)
  • 70.74 (a)
CPA2 37
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 68 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii cpa2 37
  • 54 (a)
ManyToMany
cpa4 36
  • 64.5 (n)
  • 62.65 (a)
cpa4 37
  • 62 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011434 36
  • 48.55 (n)
  • 40.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12374 37
  • 25 (a)
ManyToMany
CG14820 37
  • 29 (a)
ManyToMany
CG17633 37
  • 31 (a)
ManyToMany
CG18417 37
  • 30 (a)
ManyToMany
CG18585 37
  • 30 (a)
ManyToMany
CG2915 37
  • 27 (a)
ManyToMany
CG32379 37
  • 29 (a)
ManyToMany
CG4017 37
  • 34 (a)
ManyToMany
CG4408 37
  • 27 (a)
ManyToMany
CG7025 36
  • 48.6 (n)
  • 38.62 (a)
CG7025 37
  • 32 (a)
ManyToMany
CG8539 37
  • 25 (a)
ManyToMany
CG8560 37
  • 34 (a)
ManyToMany
CG8562 37
  • 31 (a)
ManyToMany
CG8563 37
  • 28 (a)
ManyToMany
CG8564 37
  • 18 (a)
ManyToMany
CG3097 38
  • 34 (a)
CG8563 38
  • 33 (a)
CG8539 38
  • 31 (a)
CG3108 38
  • 35 (a)
CG8560 38
  • 35 (a)
CG18585 38
  • 32 (a)
CG15769 38
  • 28 (a)
CG14820 38
  • 31 (a)
CG18415 38
  • 29 (a)
CG17633 38
  • 35 (a)
CG8945 38
  • 26 (a)
CG8562 38
  • 30 (a)
CG2915 38
  • 31 (a)
CG12374 38
  • 29 (a)
CG4408 38
  • 30 (a)
CG4017 38
  • 36 (a)
CG7025 38
  • 36 (a)
CG18417 38
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea F02D8.4 37
  • 30 (a)
ManyToMany
suro-1 37
  • 21 (a)
ManyToMany
T06A4.1 37
  • 26 (a)
ManyToMany
T06A4.3 37
  • 29 (a)
ManyToMany
W01A8.6 37
  • 29 (a)
ManyToMany
Y18H1A.9 36
  • 50.26 (n)
  • 41.03 (a)
Y18H1A.9 37
  • 32 (a)
ManyToMany
Y47G6A.19 37
  • 30 (a)
ManyToMany
ZC434.9 37
  • 21 (a)
ManyToMany
R11A5.7 38
  • 32 (a)
Y18H1A.9 38
  • 37 (a)
T06A4.3 38
  • 32 (a)
Y59C2A.1 38
  • 32 (a)
ZC434.9 38
  • 34 (a)
Y47G6A.19 38
  • 34 (a)
W01A8.6 38
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM14 37
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 41 (a)
ManyToMany
-- 37
  • 40 (a)
ManyToMany
CSA.11311 37
  • 41 (a)
ManyToMany
CSA.4005 37
  • 22 (a)
ManyToMany
Species with no ortholog for CPA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CPA2 Gene

ENSEMBL:
Gene Tree for CPA2 (if available)
TreeFam:
Gene Tree for CPA2 (if available)

Paralogs for CPA2 Gene

Paralogs for CPA2 Gene

Selected SIMAP similar genes for CPA2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CPA2: view

Variants for CPA2 Gene

Sequence variations from dbSNP and Humsavar for CPA2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs17590 -- 130,276,675(+) CTGGA(C/T)GCCCT synonymous-codon, reference
rs17591 -- 130,279,503(+) TACCA(C/T)GGACC reference, synonymous-codon
rs729332 -- 130,277,290(+) TTAGA(A/G)AGAGC intron-variant
rs1006975 -- 130,274,953(-) ATGCA(A/T)GTGTA intron-variant
rs1528179 -- 130,284,219(-) ACTGG(A/C)CCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPA2 Gene

Variant ID Type Subtype PubMed ID
nsv508481 CNV Loss 20534489
esv2673566 CNV Deletion 23128226

Relevant External Links for CPA2 Gene

HapMap Linkage Disequilibrium report
CPA2

Disorders for CPA2 Gene

Relevant External Links for CPA2

Genetic Association Database (GAD)
CPA2
Human Genome Epidemiology (HuGE) Navigator
CPA2
genes like me logo Genes that share disorders with CPA2: view

No data available for UniProtKB/Swiss-Prot for CPA2 Gene

Publications for CPA2 Gene

  1. The sequence and conformation of human pancreatic procarboxypeptidase A2. cDNA cloning, sequence analysis, and three-dimensional model. (PMID: 7896805) Catasus L. … Billeter M. (J. Biol. Chem. 1995) 2 3 4 23
  2. Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2. (PMID: 8806703) Laethem R.M. … Smith G.K. (Arch. Biochem. Biophys. 1996) 3 4 23
  3. Characterisation and preliminary X-ray diffraction analysis of human pancreatic procarboxypeptidase A2. (PMID: 9450539) Reverter D. … Aviles F.X. (FEBS Lett. 1997) 3 4 23
  4. Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2. (PMID: 10742178) Reverter D. … Aviles F.X. (Nat. Struct. Biol. 2000) 3 4 23
  5. Purification and properties of five different forms of human procarboxypeptidases. (PMID: 2920728) Pascual R. … Aviles F.X. (Eur. J. Biochem. 1989) 3 4

Products for CPA2 Gene

Sources for CPA2 Gene

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