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CPA2 Gene

protein-coding   GIFtS: 59
GCID: GC07P129906

Carboxypeptidase A2 (Pancreatic)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carboxypeptidase A2 (Pancreatic)1 2
Carboxypeptidase A22
EC 3.4.17.153
EC 3.4.178

External Ids:    HGNC: 22971   Entrez Gene: 13582   Ensembl: ENSG000001585167   OMIM: 6006885   UniProtKB: P480523   

Export aliases for CPA2 gene to outside databases

Previous GC identifers: GC07P128383 GC07P129445 GC07P129459 GC07P129500 GC07P129693 GC07P124269


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CPA2 Gene:
Three different forms of human pancreatic procarboxypeptidase A have been isolated. The encoded protein represents
the A2 form, which is a monomeric protein with different biochemical properties from the A1 and A3 forms. The A2
form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues and is a secreted protein. (provided
by RefSeq, Dec 2008)

GeneCards Summary for CPA2 Gene:
CPA2 (carboxypeptidase A2 (pancreatic)) is a protein-coding gene. Diseases associated with CPA2 include silver-russell syndrome, and pancreatitis. GO annotations related to this gene include metallocarboxypeptidase activity and carboxypeptidase activity. An important paralog of this gene is CPO.

Gene Wiki entry for CPA2 (Carboxypeptidase A2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CPA2 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   E2F-2   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CPA2 promoter sequence
   Search Chromatin IP Primers for CPA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32   Ensembl cytogenetic band:  7q32.2   HGNC cytogenetic band: 7q32

CPA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPA2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P129906:  view genomic region     (about GC identifiers)

Start:
129,906,667 bp from pter      End:
129,929,638 bp from pter
Size:
22,972 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 129,292,077-129,315,021     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CBPA2_HUMAN, P48052 (See protein sequence)
Recommended Name: Carboxypeptidase A2 precursor  
Size: 419 amino acids; 47030 Da
Cofactor: Binds 1 zinc ion per subunit
Sequence caution: Sequence=AAA74425.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH07009.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH14571.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH15140.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=EAL24092.1; Type=Erroneous gene model prediction;
3 PDB 3D structures from and Proteopedia for CPA2:
1AYE (3D)        1DTD (3D)        1O6X (3D)    
Secondary accessions: A4D1M4 C9JIK1 Q53XS1 Q96A12 Q96QN3 Q9UCF1

Explore the universe of human proteins at neXtProt for CPA2: NX_P48052

Explore proteomics data for CPA2 at MOPED

Selected DME Specific Peptides for CPA2 (P48052) (see all 9)
 YHTLEEI  VLKFSTG  FELRDTG  PTAEETW 


See CPA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001860.2  
ENSEMBL proteins: 
 ENSP00000222481   ENSP00000395582  

CPA2 Human Recombinant Protein Products:

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CPA2 Antibody Products:

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LSBio Antibodies in human, mouse, rat for CPA2

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Cloud-Clone Corp. ELISAs for CPA2
Cloud-Clone Corp. CLIAs for CPA2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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IUPHAR Guide to PHARMACOLOGY protein family classification: Carboxypeptidase A2 (pancreatic)
Metallocarboxypeptidases

3 InterPro protein domains:
 IPR003146 Prot_inh_M14A
 IPR000834 Peptidase_M14
 IPR009020 Prot_inh_propept

Graphical View of Domain Structure for InterPro Entry P48052

ProtoNet protein and cluster: P48052

2 Blocks protein domains:
IPB000834 Zinc carboxypeptidase A metalloprotease (M14)
IPB003146 Carboxypeptidase activation peptide


UniProtKB/Swiss-Prot: CBPA2_HUMAN, P48052
Similarity: Belongs to the peptidase M14 family


CPA2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CBPA2_HUMAN, P48052
Catalytic activity: Similar to that of carboxypeptidase A (EC 3.4.17.1), but with a preference for bulkier
C-terminal residues

     Enzyme Numbers (IUBMB): EC 3.4.17.151 EC 3.4.172

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004180carboxypeptidase activity IDA2920728
GO:0004181metallocarboxypeptidase activity IDA2920728
GO:0008270zinc ion binding IDA2920728
     
CPA2 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for CPA2:
 Decreased homologous recombina  Increased cell death in HCC-19 

     1 MGI phenotypic allele for Cpa2 (no phenotypes)

CPA2 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CPA2
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPA2
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPA2

miRNA
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Predesigned siRNA for gene silencing in human, mouse, rat CPA2

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPA2

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CBPA2_HUMAN, P48052: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
golgi apparatus2
lysosome1
mitochondrion1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IDA2920728

CPA2 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CPA2 About                                                                                                See pathways by source

SuperPathContained pathways About
1Protein digestion and absorption
Protein digestion and absorption
2Pancreatic secretion
Pancreatic secretion

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways




2 Kegg Pathways  (Kegg details for CPA2):
    Pancreatic secretion
Protein digestion and absorption


CPA2 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CPA2
Interactions:

    Search GeneGlobe Interaction Network for CPA2

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

Selected Interacting proteins for CPA2 (P480522 ENSP000002224814) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
InteractantInteraction Details
GeneCardExternal ID(s)
NCLENSP000003181954STRING: ENSP00000318195
CELA2AENSP000003526394STRING: ENSP00000352639
CELA2BENSP000003650754STRING: ENSP00000365075
CELA3AENSP000002901224STRING: ENSP00000290122
CELA3BENSP000003383694STRING: ENSP00000338369
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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006508proteolysis ----
GO:0007039vacuolar protein catabolic process TAS2920728

CPA2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CPA2 (CBPA2)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CPA2 gene: 
NM_001869.2  

Unigene Cluster for CPA2:

Carboxypeptidase A2 (pancreatic)
Hs.490038  [show with all ESTs]
Unigene Representative Sequence: BC007009
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000222481(uc003vpq.3) ENST00000480781 ENST00000487259(uc011kpc.1)
ENST00000416698
miRNA
Products:
     
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Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat CPA2
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CPA2 (NM_001869)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPA2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPA2
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CPA2
OriGene qSTAR qPCR primer pairs in human, mouse for CPA2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CPA2
  QuantiTect SYBR Green Assays in human, mouse, rat CPA2
  QuantiFast Probe-based Assays in human, mouse, rat CPA2

Additional mRNA sequence: 

AK293378.1 BC007009.1 BC014571.1 BC015140.1 BT007403.1 U19977.1 

5 DOTS entries:

DT.114086  DT.100780895  DT.121110016  DT.95070335  DT.86854275 

Selected AceView cDNA sequences (see all 99):

AA366335 BQ478105 CD613167 BC014571 BM967213 AA844831 BQ777569 AA366648 
AA294920 BC015140 AI961047 CK823467 AA363672 BM310372 AA363706 AA835145 
NM_001869 AA363644 AA366439 AA835098 BI766188 BX498146 AA366803 AI937229 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CPA2 expression in normal human tissues (normalized intensities)      CPA2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGCGAGACCA
CPA2 Expression
About this image


CPA2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 7) fully expand
 
 Pancreas (Endocrine System)
         Acinar Cells Pancreatic Acini
 
 Epithelial Cells
         Acinar Cells Pancreatic Acini
 
 Ovary (Reproductive System)    fully expand to see all 3 entries
         Pre-Granulosa Cells Primordial Follicle
 
 Endothelium (Cardiovascular System)    fully expand to see all 2 entries
         Endothelial Cells Blood Brain Barrier
 
 Brain (Nervous System)    fully expand to see all 2 entries
         Endothelial Cells Blood Brain Barrier
CPA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CPA2 Protein Expression

Genevestigator expression for CPA2

SOURCE GeneReport for Unigene cluster: Hs.490038
    Custom PCR Arrays for CPA2
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QuantiFast Probe-based Assays in human, mouse, rat CPA2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPA2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for CPA2 gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cpa21 , 5 carboxypeptidase A2, pancreatic1, 5 85.53(n)1
86.33(a)1
  6 (12.52 cM)5
2326801  NM_001024698.21  NP_001019869.11 
 305415825 
chicken
(Gallus gallus)
Aves CPA21 carboxypeptidase A2 (pancreatic) 72.26(n)
70.74(a)
  416682  NM_001257214.1  NP_001244143.1 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
68(a)
1 → many
GL343819.1(99048-121685)
zebrafish
(Danio rerio)
Actinopterygii cpa41 carboxypeptidase A4 64.5(n)
62.65(a)
  431764  NM_001002217.1  NP_001002217.1 
fruit fly
(Drosophila melanogaster)
Insecta CG40173
CG70251
carboxypeptidase A3
CG70251
36(a)
(best of 18)3
48.6(n)1
38.62(a)1
  340421  NM_135289.31  NP_609133.21 
worm
(Caenorhabditis elegans)
Secernentea Y18H1A.91 , 3 Y18H1A.91 37(a)
(best of 7)3
50.26(n)1
41.03(a)1
  I(748486-756927)3
1716661  NM_058375.41  NP_490776.21 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM146
Putative metalloprotease with similarity to the zi...
26(a)
1 → many
VIII(368502-369794) YHR132C


ENSEMBL Gene Tree for CPA2 (if available)
TreeFam Gene Tree for CPA2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CPA2 gene
CPO2  CPA12  CPB12  CPA62  CPA32  CPA52  CPB22  CPA42  
9 SIMAP similar genes for CPA2 using alignment to 2 protein entries:     CBPA2_HUMAN (see all proteins):
CPA1    CPA5    CPA4    DKFZp779K1333    CPO    CPA3
CPA6    CPB1    CPB2

CPA2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CPA2 (see all 544)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1384689301,2
Cuntested1129909557(+) ACGTCC/TGAGTT 2 R * stg11Minor allele frequency- T:0.00NA 4550
rs1829783041,2
--129905001(+) CCCTGA/GTTCCC 1 -- us2k10--------
rs1485636841,2
--129905036(+) CCAGAA/TATCCA 1 -- us2k10--------
rs1874461831,2
--129905050(+) TCTTTC/TCACAT 1 -- us2k10--------
rs37574021,2
C,F--129905200(+) TTCTCC/ATGCCT 1 -- us2k12Minor allele frequency- A:0.50NA 4
rs1122991161,2
C--129905257(+) GCTAAC/TTTTTT 1 -- us2k11Minor allele frequency- T:0.50NA 2
rs1923607801,2
--129905314(+) TCGATC/TTCCTG 1 -- us2k10--------
rs37574031,2
C,F--129905360(+) CTGGGA/GTTACA 1 -- us2k13Minor allele frequency- G:0.33NA 6
rs1162985681,2
F--129905734(+) ATAACG/ATGTAT 1 -- us2k11Minor allele frequency- A:0.02WA 118
rs1435447101,2
--129905881(+) GTATAC/TGTGAT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for CPA2 (129906667 - 129929638 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for CPA2:    About this table    
Variant IDTypeSubtypePubMed ID
esv2673566CNV Deletion23128226
nsv508481CNV Loss20534489

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CPA2
DNA2.0 Custom Variant and Variant Library Synthesis for CPA2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 600688    OMIM disorders: --

4 diseases for CPA2:    About MalaCards
silver-russell syndrome    pancreatitis    malaria    endotheliitis


CPA2 for disorders           About GeneDecksing

Genetic Association Database (GAD): CPA2
Human Genome Epidemiology (HuGE) Navigator: CPA2 (2 documents)

Export disorders for CPA2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CPA2 gene, integrated from 10 sources (see all 22):
(articles sorted by number of sources associating them with CPA2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The sequence and conformation of human pancreatic procarboxypeptidase A2. cDNA cloning, sequence analysis, and three-dimensional model. (PubMed id 7896805)1, 2, 3, 9 Catasus L....Billeter M. (J. Biol. Chem. 1995)
  2. Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2. (PubMed id 10742178)1, 2, 9 Reverter D.... Aviles F.X. (Nat. Struct. Biol. 2000)
  3. Characterisation and preliminary X-ray diffraction analysis of human pancreatic procarboxypeptidase A2. (PubMed id 9450539)1, 2, 9 Reverter D....Aviles F.X. (FEBS Lett. 1997)
  4. Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2. (PubMed id 8806703)1, 2, 9 Laethem R.M.... Smith G.K. (Arch. Biochem. Biophys. 1996)
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  6. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PubMed id 19401682)1, 4 Maestrini E....Monaco A.P. (Mol. Psychiatry 2010)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  8. NMR solution structure of the activation domain of human procarboxypeptidase A2. (PubMed id 12538893)1, 2 Jimenez M.A.... Rico M. (Protein Sci. 2003)
  9. A large scale test of computational protein design: folding and stability of nine completely redesigned globular proteins. (PubMed id 12948494)1, 2 Dantas G.... Baker D. (J. Mol. Biol. 2003)
  10. Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32. (PubMed id 10860668)1, 3 Hayashida S....Kishino T. (Genomics 2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1358 HGNC: 2297 AceView: CPA2 Ensembl:ENSG00000158516 euGenes: HUgn1358
ECgene: CPA2 Kegg: 1358 H-InvDB: CPA2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CPA2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CPA2 gene:
Search GeneIP for patents involving CPA2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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