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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CPA2 Gene

protein-coding   GIFtS: 60
GCID: GC07P129906

Carboxypeptidase A2 (Pancreatic)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carboxypeptidase A2 (Pancreatic)1 2
Carboxypeptidase A22
EC 3.4.17.153
EC 3.4.178

External Ids:    HGNC: 22971   Entrez Gene: 13582   Ensembl: ENSG000001585167   OMIM: 6006885   UniProtKB: P480523   

Export aliases for CPA2 gene to outside databases

Previous GC identifers: GC07P128383 GC07P129445 GC07P129459 GC07P129500 GC07P129693 GC07P124269


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CPA2 Gene:
Three different forms of human pancreatic procarboxypeptidase A have been isolated. The encoded protein represents
the A2 form, which is a monomeric protein with different biochemical properties from the A1 and A3 forms. The A2
form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues and is a secreted protein. (provided
by RefSeq, Dec 2008)

GeneCards Summary for CPA2 Gene: 
CPA2 (carboxypeptidase A2 (pancreatic)) is a protein-coding gene. Diseases associated with CPA2 include silver-russell syndrome, and pancreatitis. GO annotations related to this gene include metallocarboxypeptidase activity and carboxypeptidase activity. An important paralog of this gene is CPO.

Gene Wiki entry for CPA2 (Carboxypeptidase A2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CPA2 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   E2F-2   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CPA2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CPA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CPA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32   Ensembl cytogenetic band:  7q32.2   HGNC cytogenetic band: 7q32

CPA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPA2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P129906:  view genomic region     (about GC identifiers)

Start:
129,906,667 bp from pter      End:
129,929,638 bp from pter
Size:
22,972 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 129,292,077-129,315,021     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CBPA2_HUMAN, P48052 (See protein sequence)
Recommended Name: Carboxypeptidase A2 precursor  
Size: 419 amino acids; 47030 Da
Cofactor: Binds 1 zinc ion per subunit
Subcellular location: Secreted
Sequence caution: Sequence=AAA74425.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH07009.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH14571.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH15140.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=EAL24092.1; Type=Erroneous gene model prediction;
3 PDB 3D structures from and Proteopedia for CPA2:
1AYE (3D)        1DTD (3D)        1O6X (3D)    
Secondary accessions: A4D1M4 C9JIK1 Q53XS1 Q96A12 Q96QN3 Q9UCF1

Explore the universe of human proteins at neXtProt for CPA2: NX_P48052

Explore proteomics data for CPA2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P48052

  • 4/9 DME Specific Peptides for CPA2 (P48052) (see all 9)
     YHTLEEI  VLKFSTG  FELRDTG  PTAEETW 

    CPA2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CPA2 Protein Expression
    REFSEQ proteins: NP_001860.2  
    ENSEMBL proteins: 
     ENSP00000222481   ENSP00000395582  

    Human Recombinant Protein Products for CPA2: 
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    Novus Biologicals CPA2 Protein
    Novus Biologicals CPA2 Lysates
    Sino Biological Recombinant Protein for CPA2
    Sino Biological Cell Lysate for CPA2 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CPA2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA2920728

    CPA2 for ontologies           About GeneDecksing



    CPA2 Antibody Products: 
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    Assay Products for CPA2: 
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    Cloud-Clone Corp. CLIAs for CPA2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: Carboxypeptidase A2 (pancreatic) 
    Metallocarboxypeptidases

    3 InterPro protein domains:
     IPR003146 Prot_inh_M14A
     IPR000834 Peptidase_M14
     IPR009020 Prot_inh_propept

    Graphical View of Domain Structure for InterPro Entry P48052

    ProtoNet protein and cluster: P48052

    2 Blocks protein domains:
    IPB000834 Zinc carboxypeptidase A metalloprotease (M14)
    IPB003146 Carboxypeptidase activation peptide


    UniProtKB/Swiss-Prot: CBPA2_HUMAN, P48052
    Similarity: Belongs to the peptidase M14 family


    CPA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBPA2_HUMAN, P48052
    Catalytic activity: Similar to that of carboxypeptidase A (EC 3.4.17.1), but with a preference for bulkier
    C-terminal residues

         Enzyme Numbers (IUBMB): EC 3.4.17.151 EC 3.4.172

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004180carboxypeptidase activity IDA2920728
    GO:0004181metallocarboxypeptidase activity IDA2920728
    GO:0008270zinc ion binding IDA2920728
         
    CPA2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CPA2:
     Decreased homologous recombina  Increased cell death in HCC-19 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CPA2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CPA2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CPA2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPA2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPA2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CPA2
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    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CPA2

    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of CPA2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPA2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CPA2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Protein digestion and absorption
    Protein digestion and absorption
    2Pancreatic secretion
    Pancreatic secretion

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2         Kegg Pathways  (Kegg details for CPA2):
        Pancreatic secretion
    Protein digestion and absorption


    CPA2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CPA2

    1 Interacting protein for CPA2 (P480522) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    --P815112MINT-24825
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0007039vacuolar protein catabolic process TAS2920728

    CPA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CPA2 (CBPA2)

    Search CenterWatch for drugs/clinical trials and news about CPA2 / CBPA2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CPA2 gene: 
    NM_001869.2  

    Unigene Cluster for CPA2:

    Carboxypeptidase A2 (pancreatic)
    Hs.490038  [show with all ESTs]
    Unigene Representative Sequence: BC007009
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222481(uc003vpq.3) ENST00000480781 ENST00000487259(uc011kpc.1)
    ENST00000416698
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CPA2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CPA2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CPA2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CPA2
    Clone
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    OriGene ORF clones in mouse, rat for CPA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CPA2 (NM_001869)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CPA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CPA2
    Sirion Biotech Customized lentivirus for stable overexpression of CPA2 
                         Customized lentivirus expression plasmids for stable overexpression of CPA2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CPA2
    OriGene qSTAR qPCR primer pairs in human, mouse for CPA2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CPA2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CPA2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CPA2

    Additional mRNA sequence: 

    AK293378.1 BC007009.1 BC014571.1 BC015140.1 BT007403.1 U19977.1 

    5 DOTS entries:

    DT.114086  DT.100780895  DT.121110016  DT.95070335  DT.86854275 

    24/99 AceView cDNA sequences (see all 99):

    BQ777569 BC014571 BQ478105 AA363672 AI961047 CK823467 BM967213 BC015140 
    AA294920 AA366648 CD613167 AA366335 AA844831 BM310372 AI937229 BM924292 
    AI434875 AA363706 BV198170 AA835098 BQ777868 AA366154 BM263014 BX106544 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CPA2 expression in normal human tissues (normalized intensities)      CPA2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCGAGACCA
    CPA2 Expression
    About this image


    CPA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 3 entries
             Acinar Cells Pancreatic Acini
             pancreas ; exocrine glandular cells   
             Pancreatic Islet   
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Blood Brain Barrier (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier

    See CPA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CPA2

    SOURCE GeneReport for Unigene cluster: Hs.490038
        SABiosciences Custom PCR Arrays for CPA2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CPA2 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpa21 , 5 carboxypeptidase A2, pancreatic1, 5 85.53(n)1
    86.33(a)1
      6 (12.52 cM)5
    2326801  NM_001024698.21  NP_001019869.11 
     305415825 
    chicken
    (Gallus gallus)
    Aves CPA26
    Uncharacterized protein
    69(a)
    1 → many
    1(902989-909381)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    68(a)
    1 → many
    GL343819.1(99048-121685)
    zebrafish
    (Danio rerio)
    Actinopterygii cpa41 carboxypeptidase A4 64.5(n)
    62.65(a)
      431764  NM_001002217.1  NP_001002217.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG40173
    CG70251
    carboxypeptidase A3
    CG70251
    36(a)
    (best of 18)3
    48.6(n)1
    38.62(a)1
      340421  NM_135289.31  NP_609133.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y18H1A.91 , 3 Protein Y18H1A.91 37(a)
    (best of 7)3
    50.26(n)1
    41.03(a)1
      I(748486-756927)3
    1716661  NM_058375.31  NP_490776.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ECM146
    Putative metalloprotease with similarity to the zi...
    26(a)
    1 → many
    VIII(368502-369794)


    ENSEMBL Gene Tree for CPA2 (if available)
    TreeFam Gene Tree for CPA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CPA2 gene
    CPO2  CPA12  CPA62  CPB12  CPA32  CPA52  CPB22  CPA42  
    9 SIMAP similar genes for CPA2 using alignment to 2 protein entries:     CBPA2_HUMAN (see all proteins):
    CPA1    CPA5    CPA4    DKFZp779K1333    CPO    CPA3
    CPA6    CPB1    CPB2

    CPA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/544 SNPs in CPA2 are shown (see all 544)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1384689301,2
    Cuntested1129909557(+) ACGTCC/TGAGTT 2 R * stg11Minor allele frequency- T:0.00NA 4550
    rs1829783041,2
    --129905001(+) CCCTGA/GTTCCC 1 -- us2k10--------
    rs1485636841,2
    --129905036(+) CCAGAA/TATCCA 1 -- us2k10--------
    rs1874461831,2
    --129905050(+) TCTTTC/TCACAT 1 -- us2k10--------
    rs37574021,2
    C,F--129905200(+) TTCTCC/ATGCCT 1 -- us2k12Minor allele frequency- A:0.50NA 4
    rs1122991161,2
    C--129905257(+) GCTAAC/TTTTTT 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1923607801,2
    --129905314(+) TCGATC/TTCCTG 1 -- us2k10--------
    rs37574031,2
    C,F--129905360(+) CTGGGA/GTTACA 1 -- us2k13Minor allele frequency- G:0.33NA 6
    rs1162985681,2
    F--129905734(+) ATAACG/ATGTAT 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1435447101,2
    --129905881(+) GTATAC/TGTGAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CPA2 (129906667 - 129929638 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CPA2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2673566CNV Deletion23128226
    nsv508481CNV Loss20534489

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CPA2
    DNA2.0 Custom Variant and Variant Library Synthesis for CPA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600688    OMIM disorders: --

    2 diseases for CPA2:    About MalaCards
    silver-russell syndrome    pancreatitis


    CPA2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CPA2
    Human Genome Epidemiology (HuGE) Navigator: CPA2 (2 documents)

    Export disorders for CPA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CPA2 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with CPA2)
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    1. The sequence and conformation of human pancreatic procarboxypeptidase A2. cDNA cloning, sequence analysis, and three-dimensional model. (PubMed id 7896805)1, 2, 3, 9 Catasus L....Billeter M. (1995)
    2. Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2. (PubMed id 10742178)1, 2, 9 Reverter D.... Aviles F.X. (2000)
    3. Characterisation and preliminary X-ray diffraction analysis of human pancreatic procarboxypeptidase A2. (PubMed id 9450539)1, 2, 9 Reverter D....Aviles F.X. (1997)
    4. Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2. (PubMed id 8806703)1, 2, 9 Laethem R.M.... Smith G.K. (1996)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PubMed id 19401682)1, 4 Maestrini E....Monaco A.P. (2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. NMR solution structure of the activation domain of human procarboxypeptidase A2. (PubMed id 12538893)1, 2 Jimenez M.A.... Rico M. (2003)
    9. A large scale test of computational protein design: folding and stability of nine completely redesigned globular proteins. (PubMed id 12948494)1, 2 Dantas G.... Baker D. (2003)
    10. Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32. (PubMed id 10860668)1, 3 Hayashida S....Kishino T. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1358 HGNC: 2297 AceView: CPA2 Ensembl:ENSG00000158516 euGenes: HUgn1358
    ECgene: CPA2 Kegg: 1358 H-InvDB: CPA2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CPA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CPA2 gene:
    Search GeneIP for patents involving CPA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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