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Aliases for CPA1 Gene

Aliases for CPA1 Gene

  • Carboxypeptidase A1 (Pancreatic) 2 3
  • Pancreatic Carboxypeptidase A 2 3
  • EC 3.4.17.1 4 63
  • CPA 3 4
  • Carboxypeptidase A1 3
  • EC 3.4.17 63

External Ids for CPA1 Gene

Previous HGNC Symbols for CPA1 Gene

  • CPA

Previous GeneCards Identifiers for CPA1 Gene

  • GC07P128496
  • GC07P129559
  • GC07P129573
  • GC07P129614
  • GC07P129807
  • GC07P130020
  • GC07P124382

Summaries for CPA1 Gene

Entrez Gene Summary for CPA1 Gene

  • This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. This enzyme is produced in the pancreas and preferentially cleaves C-terminal branched-chain and aromatic amino acids from dietary proteins. This gene and several family members are present in a gene cluster on chromosome 7. Mutations in this gene may be linked to chronic pancreatitis, while elevated protein levels may be associated with pancreatic cancer. [provided by RefSeq, Jan 2015]

GeneCards Summary for CPA1 Gene

CPA1 (Carboxypeptidase A1 (Pancreatic)) is a Protein Coding gene. Diseases associated with CPA1 include tracheal stenosis and pancreatitis, hereditary. Among its related pathways are Pancreatic secretion and Protein digestion and absorption. GO annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPA3.

UniProtKB/Swiss-Prot for CPA1 Gene

  • Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.

Gene Wiki entry for CPA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPA1 Gene

Genomics for CPA1 Gene

Regulatory Elements for CPA1 Gene

Genomic Location for CPA1 Gene

Start:
130,380,339 bp from pter
End:
130,388,114 bp from pter
Size:
7,776 bases
Orientation:
Plus strand

Genomic View for CPA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CPA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPA1 Gene

Proteins for CPA1 Gene

  • Protein details for CPA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15085-CBPA1_HUMAN
    Recommended name:
    Carboxypeptidase A1
    Protein Accession:
    P15085
    Secondary Accessions:
    • A4D1M1
    • Q53XU0
    • Q9BS67
    • Q9UCF2

    Protein attributes for CPA1 Gene

    Size:
    419 amino acids
    Molecular mass:
    47140 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Monomer. May form a complex with proelastase 2.

    Three dimensional structures from OCA and Proteopedia for CPA1 Gene

neXtProt entry for CPA1 Gene

Proteomics data for CPA1 Gene at MOPED

Post-translational modifications for CPA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPA1 Gene

Antibody Products

  • R&D Systems Antibodies for CPA1 (Carboxypeptidase A1/CPA1)

Domains for CPA1 Gene

Gene Families for CPA1 Gene

Suggested Antigen Peptide Sequences for CPA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15085

UniProtKB/Swiss-Prot:

CBPA1_HUMAN :
  • P15085
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPA1: view

Function for CPA1 Gene

Molecular function for CPA1 Gene

GENATLAS Biochemistry: carboxypeptidase A1,pancreatic
UniProtKB/Swiss-Prot CatalyticActivity: Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
UniProtKB/Swiss-Prot Function: Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.

Enzyme Numbers (IUBMB) for CPA1 Gene

Gene Ontology (GO) - Molecular Function for CPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity --
GO:0004181 metallocarboxypeptidase activity IEA --
GO:0008238 exopeptidase activity --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CPA1: view

Phenotypes for CPA1 Gene

MGI mutant phenotypes for CPA1:
inferred from 1 alleles
GenomeRNAi human phenotypes for CPA1:
genes like me logo Genes that share phenotypes with CPA1: view

Animal Model Products

CRISPR Products

miRNA for CPA1 Gene

miRTarBase miRNAs that target CPA1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPA1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CPA1 Gene

Localization for CPA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPA1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPA1 Gene COMPARTMENTS Subcellular localization image for CPA1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
lysosome 1

Gene Ontology (GO) - Cellular Components for CPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 2920728
genes like me logo Genes that share ontologies with CPA1: view

Pathways for CPA1 Gene

genes like me logo Genes that share pathways with CPA1: view

Pathways by source for CPA1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for CPA1 Gene

Gene Ontology (GO) - Biological Process for CPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with CPA1: view

Compounds for CPA1 Gene

(5) HMDB Compounds for CPA1 Gene

Compound Synonyms Cas Number PubMed IDs
Kinetensin
  • Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu
103131-69-7
Kinetensin 1-8
  • Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe
51833-69-3
Neuromedin N
  • Ile-Pro-Tyr-Ile-Leu
102577-25-3
Neuromedin N (1-4)
  • Ile-Pro-Tyr-Ile
Not Available
Zinc
  • Zinc
7440-66-6

(8) Novoseek inferred chemical compound relationships for CPA1 Gene

Compound -log(P) Hits PubMed IDs
1-aminocyclohexane-1-carboxylic acid 89.6 1
zinc 49.9 7
phenylalanine 45.1 1
methotrexate 29.9 3
sulfur 22.5 1
genes like me logo Genes that share compounds with CPA1: view

Transcripts for CPA1 Gene

Unigene Clusters for CPA1 Gene

Carboxypeptidase A1 (pancreatic):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CPA1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPA1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^
SP1: - - -
SP2: -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - - -
SP10: - - - - - - - - - -
SP11:
SP12:
SP13:

ExUns: 12a · 12b ^ 13a · 13b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:

Relevant External Links for CPA1 Gene

GeneLoc Exon Structure for
CPA1
ECgene alternative splicing isoforms for
CPA1

Expression for CPA1 Gene

mRNA expression in normal human tissues for CPA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPA1 Gene

This gene is overexpressed in Pancreas (52.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CPA1 Gene

SOURCE GeneReport for Unigene cluster for CPA1 Gene Hs.2879

genes like me logo Genes that share expressions with CPA1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CPA1 Gene

Orthologs for CPA1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CPA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPA1 35
  • 98.81 (n)
  • 99.05 (a)
CPA1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPA1 35
  • 86.48 (n)
  • 81.86 (a)
CPA1 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPA1 35
  • 89.27 (n)
  • 88.86 (a)
CPA1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpa1 35
  • 83.54 (n)
  • 82.06 (a)
Cpa1 16
Cpa1 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPA1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPA1 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpa1 35
  • 83.62 (n)
  • 84.28 (a)
chicken
(Gallus gallus)
Aves CPA1 35
  • 75 (n)
  • 73.5 (a)
CPA1 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPA1 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC64526 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cpa1 35
  • 65.67 (n)
  • 67.08 (a)
Str.8435 35
zebrafish
(Danio rerio)
Actinopterygii cpa 35
cpa1 36
  • 62 (a)
OneToMany
cpa5 35
  • 67.9 (n)
  • 65.02 (a)
cpa5 36
  • 64 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta CBPA1_ANOGA 35
  • 51.9 (n)
  • 38.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12374 36
  • 27 (a)
ManyToMany
CG14820 36
  • 32 (a)
ManyToMany
CG17633 35
  • 53.03 (n)
  • 36.04 (a)
CG17633 36
  • 30 (a)
ManyToMany
CG18417 36
  • 26 (a)
ManyToMany
CG18585 36
  • 35 (a)
ManyToMany
CG2915 36
  • 26 (a)
ManyToMany
CG3097 36
  • 29 (a)
ManyToMany
CG3108 36
  • 11 (a)
ManyToMany
CG32379 36
  • 28 (a)
ManyToMany
CG4017 36
  • 34 (a)
ManyToMany
CG42264 36
  • 18 (a)
ManyToMany
CG4408 36
  • 25 (a)
ManyToMany
CG7025 36
  • 34 (a)
ManyToMany
CG8539 36
  • 24 (a)
ManyToMany
CG8560 36
  • 28 (a)
ManyToMany
CG8562 36
  • 27 (a)
ManyToMany
CG8563 36
  • 29 (a)
ManyToMany
CG8564 36
  • 16 (a)
ManyToMany
CG8945 36
  • 8 (a)
ManyToMany
CG3097 37
  • 33 (a)
CG8563 37
  • 34 (a)
CG8539 37
  • 29 (a)
CG3108 37
  • 32 (a)
CG8560 37
  • 30 (a)
CG18585 37
  • 35 (a)
CG15769 37
  • 28 (a)
CG14820 37
  • 34 (a)
CG18415 37
  • 30 (a)
CG17633 37
  • 33 (a)
CG8945 37
  • 26 (a)
CG8562 37
  • 28 (a)
CG2915 37
  • 28 (a)
CG12374 37
  • 29 (a)
CG4408 37
  • 28 (a)
CG4017 37
  • 33 (a)
CG7025 37
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea F02D8.4 36
  • 27 (a)
ManyToMany
suro-1 36
  • 19 (a)
ManyToMany
T06A4.1 36
  • 24 (a)
ManyToMany
T06A4.3 36
  • 27 (a)
ManyToMany
W01A8.6 36
  • 27 (a)
ManyToMany
Y18H1A.9 36
  • 31 (a)
ManyToMany
Y47G6A.19 36
  • 27 (a)
ManyToMany
Y59C2A.1 36
  • 29 (a)
ManyToMany
ZC434.9 36
  • 19 (a)
ManyToMany
R11A5.7 37
  • 29 (a)
Y18H1A.9 37
  • 36 (a)
T06A4.3 37
  • 28 (a)
Y59C2A.1 37
  • 31 (a)
ZC434.9 37
  • 31 (a)
Y47G6A.19 37
  • 31 (a)
W01A8.6 37
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM14 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
CSA.11311 36
  • 37 (a)
ManyToMany
CSA.4005 36
  • 21 (a)
ManyToMany
Species with no ortholog for CPA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPA1 Gene

ENSEMBL:
Gene Tree for CPA1 (if available)
TreeFam:
Gene Tree for CPA1 (if available)

Paralogs for CPA1 Gene

Paralogs for CPA1 Gene

Selected SIMAP similar genes for CPA1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CPA1: view

Variants for CPA1 Gene

Sequence variations from dbSNP and Humsavar for CPA1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs741486 -- 130,384,169(-) AAAAA(C/T)AGAAG intron-variant
rs741487 -- 130,384,276(-) CCATA(C/G)GATGG intron-variant
rs968404 -- 130,382,200(+) ATTTA(C/T)GTGCT reference, synonymous-codon
rs1126899 -- 130,381,647(+) CGGGG(C/G/T)CCTGC synonymous-codon, reference
rs2239604 -- 130,381,490(+) TCTGG(C/T)CCTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPA1 Gene

Variant ID Type Subtype PubMed ID
esv23964 CNV Gain 19812545
nsv515945 CNV Gain+Loss 19592680

Relevant External Links for CPA1 Gene

HapMap Linkage Disequilibrium report
CPA1
Human Gene Mutation Database (HGMD)
CPA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPA1 Gene

Disorders for CPA1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for CPA1 Gene including...

Search for CPA1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CPA1 Gene

(1) Novoseek inferred disease relationships for CPA1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for CPA1

Genetic Association Database (GAD)
CPA1
genes like me logo Genes that share disorders with CPA1: view

No data available for UniProtKB/Swiss-Prot for CPA1 Gene

Publications for CPA1 Gene

  1. Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2. (PMID: 8806703) Laethem R.M. … Smith G.K. (Arch. Biochem. Biophys. 1996) 3 4 23
  2. Human carboxypeptidase A identifies a BglII RFLP and maps to 7q31- qter. (PMID: 1969228) Stewart E.A. … Bowcock A.M. (Am. J. Hum. Genet. 1990) 3 4 23
  3. Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid). (PMID: 18566513) Pallares I. … Vendrell J. (Acta Crystallogr. D 2008) 3 4 23
  4. Mammalian metallopeptidase inhibition at the defense barrier of Ascaris parasite. (PMID: 19179285) Sanglas L. … Arolas J.L. (Proc. Natl. Acad. Sci. U.S.A. 2009) 4 23
  5. cDNA cloning and sequence analysis of human pancreatic procarboxypeptidase A1. (PMID: 1417781) Catasus L. … Puigserver A. (Biochem. J. 1992) 3 4

Products for CPA1 Gene

Sources for CPA1 Gene

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