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CPA1 Gene

protein-coding   GIFtS: 67
GCID: GC07P130020

Carboxypeptidase A1 (Pancreatic)


(Previous symbol: CPA)
  See CPA1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carboxypeptidase A1 (Pancreatic)1 2
CPA1 2 3
Pancreatic Carboxypeptidase A1 2
EC 3.4.17.13 8
Carboxypeptidase A12
EC 3.4.178

External Ids:    HGNC: 22961   Entrez Gene: 13572   Ensembl: ENSG000000917047   OMIM: 1148505   UniProtKB: P150853   

Export aliases for CPA1 gene to outside databases

Previous GC identifers: GC07P128496 GC07P129559 GC07P129573 GC07P129614 GC07P129807 GC07P124382


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CPA1 Gene:
Three different forms of human pancreatic procarboxypeptidase A have been isolated. This gene encodes a monomeric
pancreatic exopeptidase involved in zymogen inhibition. (provided by RefSeq, Jan 2009)

GeneCards Summary for CPA1 Gene:
CPA1 (carboxypeptidase A1 (pancreatic)) is a protein-coding gene. Diseases associated with CPA1 include tracheal stenosis, and pancreatitis, chronic. GO annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPO.

UniProtKB/Swiss-Prot: CBPA1_HUMAN, P15085
Function: Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with
-Asp, -Glu, -Arg, -Lys or -Pro

Gene Wiki entry for CPA1 (Carboxypeptidase A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CPA1 gene promoter:
         SREBP-1a   SREBP-1c   p300   Lmo2   STAT3   LUN-1   SREBP-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CPA1 promoter sequence
   Search Chromatin IP Primers for CPA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CPA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32   Ensembl cytogenetic band:  7q32.2   HGNC cytogenetic band: 7q32

CPA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CPA1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P130020:  view genomic region     (about GC identifiers)

Start:
130,020,180 bp from pter      End:
130,027,955 bp from pter
Size:
7,776 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 129,405,674-129,413,334     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CBPA1_HUMAN, P15085 (See protein sequence)
Recommended Name: Carboxypeptidase A1 precursor  
Size: 419 amino acids; 47140 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Monomer. May form a complex with proelastase 2
2 PDB 3D structures from and Proteopedia for CPA1:
2V77 (3D)        3FJU (3D)    
Secondary accessions: A4D1M1 Q53XU0 Q9BS67 Q9UCF2

Explore the universe of human proteins at neXtProt for CPA1: NX_P15085

Explore proteomics data for CPA1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CPA1 (P15085) (see all 11)
     YHTLEEI  GIHSREW  VLKFSTG  FELRDTG 


    See CPA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001859.1  
    ENSEMBL proteins: 
     ENSP00000420218   ENSP00000011292   ENSP00000475021   ENSP00000419408   ENSP00000419497  

    CPA1 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for CPA1
    Sino Biological Cell Lysate for CPA1
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    Cloud-Clone Corp. Proteins for CPA1

     
    Search eBioscience for Proteins for CPA1 

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CPA1
    Cloud-Clone Corp. CLIAs for CPA1
    Search eBioscience for ELISAs for CPA1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Carboxypeptidase A1 (pancreatic)
    Metallocarboxypeptidases

    3 InterPro protein domains:
     IPR003146 Prot_inh_M14A
     IPR000834 Peptidase_M14
     IPR009020 Prot_inh_propept

    Graphical View of Domain Structure for InterPro Entry P15085

    ProtoNet protein and cluster: P15085

    2 Blocks protein domains:
    IPB000834 Zinc carboxypeptidase A metalloprotease (M14)
    IPB003146 Carboxypeptidase activation peptide


    UniProtKB/Swiss-Prot: CBPA1_HUMAN, P15085
    Similarity: Belongs to the peptidase M14 family


    Find genes that share domains with CPA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CBPA1_HUMAN, P15085
    Function: Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with
    -Asp, -Glu, -Arg, -Lys or -Pro
    Catalytic activity: Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or
    -Pro

         Genatlas biochemistry entry for CPA1:
    carboxypeptidase A1,pancreatic

         Enzyme Numbers (IUBMB): EC 3.4.17.11 2 EC 3.4.172

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004180carboxypeptidase activity ----
    GO:0004181metallocarboxypeptidase activity IEA--
    GO:0008238exopeptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with CPA1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CPA1:
     Increased viability after born 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Cpa1):
     normal 

    Find genes that share phenotypes with CPA1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cpa1tm1Lex for CPA1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CPA1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CPA1

    miRNA
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    miRTarBase miRNAs that target CPA1:
    hsa-mir-26b-5p (MIRT028882)

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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CPA1 (NM_001868)
    Sino Biological Human cDNA Clone for CPA1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CBPA1_HUMAN, P15085: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane2
    lysosome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA2920728

    Find genes that share ontologies with CPA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CPA1 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein digestion and absorption
    Protein digestion and absorption
    2Pancreatic secretion
    Pancreatic secretion


    Find genes that share SuperPaths with CPA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2 Kegg Pathways  (Kegg details for CPA1):
        Pancreatic secretion
    Protein digestion and absorption

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CPA1: 
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CPA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for CPA1 (P150853 ENSP000000112924) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARRB1P494073I2D: score=1 
    NCLENSP000003181954STRING: ENSP00000318195
    CELA2AENSP000003526394STRING: ENSP00000352639
    CELA2BENSP000003650754STRING: ENSP00000365075
    CELA3AENSP000002901224STRING: ENSP00000290122
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS2920728

    Find genes that share ontologies with CPA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CPA1 (CBPA1)

    5 HMDB Compounds for CPA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    KinetensinIle-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu 103131-69-7--
    Kinetensin 1-8Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe;KT(1-8) 51833-69-3--
    Neuromedin NIle-Pro-Tyr-Ile-Leu;NN 102577-25-3--
    Neuromedin N (1-4)Ile-Pro-Tyr-Ile ----
    ZincZinc (see all 2)7440-66-6--

    Selected DrugBank Compounds for CPA1 (see all 13)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    D-Cysteine-- 921-01-7target--17139284 17016423 10592235
    (2R)-2-benzyl-3-nitropropanoic acid-- --target--10592235
    (2R)-4,4-dihydroxy-5-nitro-2-(phenylmethyl)pentanoic acid-- --target--10592235
    2-Benzyl-3-Iodopropanoic Acid-- --target--10592235
    Alpha-Hydroxy-Beta-Phenyl-Propionic Acid-- --target--10592235
    D-[(Amino)Carbonyl]Phenylalanine-- --target--10592235
    D-[(N-Hydroxyamino)Carbonyl]Phenylalanine-- --target--10592235
    L-BENZYLSUCCINIC ACID-- --target--10592235
    L-[(N-Hydroxyamino)Carbonyl]Phenylalanine-- --target--10592235
    O-(((1R)-((N-(PHENYL-METHOXY-CARBONYL)-ALANYL)-AMINO)METHYL)HYDROXYPHOSPHINYL)3-L-PHENYLLACTATE-- --target--10592235

    8 Novoseek inferred chemical compound relationships for CPA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    1-aminocyclohexane-1-carboxylic acid 89.6 1 17366528 (1)
    zinc 49.9 8 15320722 (3), 12369980 (1), 2300547 (1), 18566513 (1) (see all 5)
    phenylalanine 45.1 1 1629626 (1)
    methotrexate 29.9 4 9188478 (1), 9893962 (1), 10022548 (1)
    sulfur 22.5 1 17366528 (1)
    silver 19.8 2 17366528 (2)
    leucine 19 2 9793838 (1), 1629626 (1)
    tyrosine 14.3 4 1629626 (1), 17366528 (1)



    Find genes that share compounds with CPA1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CPA1 gene: 
    NM_001868.2  

    Unigene Cluster for CPA1:

    Carboxypeptidase A1 (pancreatic)
    Hs.2879  [show with all ESTs]
    Unigene Representative Sequence: AK124421
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481342 ENST00000011292(uc003vpw.2 uc003vpx.3) ENST00000491460(uc011kpf.1)
    ENST00000604896 ENST00000476062 ENST00000484324 ENST00000470838 ENST00000479106
    ENST00000478096
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat CPA1

    Additional mRNA sequence: 

    AK124421.1 AK131054.1 AK291493.1 AK293366.1 BC005279.1 BT007313.1 X67318.1 

    20 DOTS entries:

    DT.219484  DT.97764269  DT.95284142  DT.100764118  DT.100661019  DT.100009621  DT.100774136  DT.102831301 
    DT.100774266  DT.121112301  DT.121112271  DT.121112286  DT.121112311  DT.121112324  DT.121112334  DT.121112337 
    DT.121112343  DT.121112346  DT.121112351  DT.95284139 

    Selected AceView cDNA sequences (see all 290):

    AA366652 BQ549118 AA366570 AA366640 AA835139 AA366479 BI771092 BU786919 
    AA366369 AW874324 AA367205 AA367177 AW583682 AA295627 BI769906 AA366474 
    BI769758 T29243 BU783396 CR626683 AA363665 AA367365 AA366289 BM055384 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CPA1 (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^
    SP1:                          -     -                                                                                                                 -         
    SP2:                                -                                                                                                                           
    SP3:              -     -     -     -                                                                                                                           
    SP4:                    -     -     -                                                                                                                           
    SP5:                          -     -                 -     -     -     -     -     -     -     -     -     -     -                                   -         

    ExUns: 12a · 12b ^ 13a · 13b
    SP1:        -               
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for CPA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CPA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCACACCC
    CPA1 Expression
    About this image


    CPA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 4 entries
             Acinar Cells Pancreatic Acini
             Pancreatic-like cells
     
     Epithelial Cells
             Acinar Cells Pancreatic Acini
     
     Kidney (Urinary System)
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
     
     Heart (Cardiovascular System)
     
     Lung (Respiratory System)
    CPA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CPA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2879
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CPA1: 
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CPA1
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    QuantiFast Probe-based Assays in human, mouse, rat CPA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CPA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CPA1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cpa11 , 5 carboxypeptidase A1, pancreatic1, 5 83.54(n)1
    82.06(a)1
      6 (12.52 cM)5
    1096971  NM_025350.31  NP_079626.21 
     306392185 
    chicken
    (Gallus gallus)
    Aves CPA11 carboxypeptidase A1 (pancreatic) 75(n)
    73.5(a)
      395276  NM_204584.1  NP_989915.1 
    lizard
    (Anolis carolinensis)
    Reptilia CPA16
    carboxypeptidase A1 (pancreatic)
    71(a)
    1 ↔ 1
    GL343819.1(51165-66599)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC645262 hypothetical protein MGC64526 77.54(n)    BC056856.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cpa2 carboxypeptidase A 77.68(n)   246092  BC056300.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG185853
    CG176331
    CG176331 35(a)
    (best of 17)3
    53.03(n)1
    36.04(a)1
      28C13
    342971  NM_135466.41  NP_609310.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y18H1A.93   -- 36(a)
    (best of 7)
      I(748486-756927)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ECM146
    Putative metalloprotease with similarity to the zi...
    27(a)
    1 → many
    VIII(368502-369794) YHR132C


    ENSEMBL Gene Tree for CPA1 (if available)
    TreeFam Gene Tree for CPA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CPA1 gene
    CPO2  CPA22  CPB12  CPA62  CPA32  CPA52  CPB22  CPA42  
    9 SIMAP similar genes for CPA1 using alignment to 5 protein entries:     CBPA1_HUMAN (see all proteins):
    CPA5    CPA2    CPA4    DKFZp779K1333    CPB1    CPA3
    CPO    CPA6    CPB2

    Find genes that share paralogs with CPA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CPA1 (see all 250)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1902697151,2
    --130018297(+) AAGACC/TTAAGT 1 -- us2k10--------
    rs1159873931,2
    F--130018361(+) GAGGGT/CTGCAT 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1147495581,2
    F--130018402(+) ACATAG/ATGAGA 1 -- us2k12Minor allele frequency- A:0.03WA NA 238
    rs1819279271,2
    --130018408(+) TGAGAC/TTCCAT 1 -- us2k10--------
    rs1465030751,2
    --130018443(+) AGCCAA/GGTGTG 1 -- us2k10--------
    rs37574051,2
    C--130018544(+) ggtgcC/Tactgc 1 -- us2k10--------
    rs734845291,2
    C,F--130018559(+) CACAGC/ACTGGG 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs344697521,2
    C--130018587(+) GTCTT-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1177324431,2
    F--130018604(+) AAGGCC/TTAGGT 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1162107661,2
    C,F--130018693(+) CATACC/AACATC 1 -- us2k11Minor allele frequency- A:0.04WA 118

    HapMap Linkage Disequilibrium report for CPA1 (130020180 - 130027955 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CPA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv23964CNV Gain19812545
    nsv515945CNV Gain+Loss19592680

    Human Gene Mutation Database (HGMD): CPA1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CPA1
    DNA2.0 Custom Variant and Variant Library Synthesis for CPA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 114850    OMIM disorders: --

    2 diseases for CPA1:    
    About MalaCards
    tracheal stenosis    pancreatitis, chronic

    1 disease from the University of Copenhagen DISEASES database for CPA1:
    Tracheal stenosis

    Find genes that share disorders with CPA1           About GenesLikeMe

    1 Novoseek inferred disease relationship for CPA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 18171715 (1)

    Genetic Association Database (GAD): CPA1

    Export disorders for CPA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for CPA1 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with CPA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid). (PubMed id 18566513)1, 2, 9 Pallares I.... Vendrell J. (Acta Crystallogr. D 2008)
    2. Human carboxypeptidase A identifies a BglII RFLP and maps to 7q31- qter. (PubMed id 1969228)1, 2, 9 Stewart E.A.... Bowcock A.M. (Am. J. Hum. Genet. 1990)
    3. Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2. (PubMed id 8806703)1, 2, 9 Laethem R.M.... Smith G.K. (Arch. Biochem. Biophys. 1996)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    6. cDNA cloning and sequence analysis of human pancreatic procarboxypeptidase A1. (PubMed id 1417781)1, 2 Catasus L....Puigserver A. (Biochem. J. 1992)
    7. Further studies on the human pancreatic binary complexes involving procarboxypeptidase A. (PubMed id 2307232)1, 2 Moulard M.... Chapus C. (FEBS Lett. 1990)
    8. Purification and properties of five different forms of human procarboxypeptidases. (PubMed id 2920728)1, 2 Pascual R.... Aviles F.X. (Eur. J. Biochem. 1989)
    9. Mammalian metallopeptidase inhibition at the defense barrier of Ascaris parasite. (PubMed id 19179285)2, 9 Sanglas L.... Arolas J.L. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    10. Variants in CPA1 are strongly associated with early onset chronic pancreatitis. (PubMed id 23955596)1 Witt H....Sahin-TA^th M. (Nat. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 1357 HGNC: 2296 AceView: CPA1 Ensembl:ENSG00000091704 euGenes: HUgn1357
    ECgene: CPA1 Kegg: 1357 H-InvDB: CPA1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CPA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CPA1 gene:
    Search GeneIP for patents involving CPA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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