Aliases for CPA1 Gene
External Ids for CPA1 Gene
Previous HGNC Symbols for CPA1 Gene
Previous GeneCards Identifiers for CPA1 Gene
This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. This enzyme is produced in the pancreas and preferentially cleaves C-terminal branched-chain and aromatic amino acids from dietary proteins. This gene and several family members are present in a gene cluster on chromosome 7. Mutations in this gene may be linked to chronic pancreatitis, while elevated protein levels may be associated with pancreatic cancer. [provided by RefSeq, Jan 2015]
GeneCards Summary for CPA1 Gene
CPA1 (Carboxypeptidase A1 (Pancreatic)) is a Protein Coding gene. Diseases associated with CPA1 include borna disease and pancreatitis, hereditary. Among its related pathways are Pancreatic secretion and Protein digestion and absorption. GO annotations related to this gene include metallocarboxypeptidase activity and exopeptidase activity. An important paralog of this gene is CPA3.
UniProtKB/Swiss-Prot for CPA1 Gene
Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.