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Aliases for CPA1 Gene

Aliases for CPA1 Gene

  • Carboxypeptidase A1 2 3 5
  • Carboxypeptidase A1 (Pancreatic) 2 3
  • Pancreatic Carboxypeptidase A 2 3
  • EC 3.4.17.1 4 63
  • CPA 3 4
  • EC 3.4.17 63

External Ids for CPA1 Gene

Previous HGNC Symbols for CPA1 Gene

  • CPA

Previous GeneCards Identifiers for CPA1 Gene

  • GC07P128496
  • GC07P129559
  • GC07P129573
  • GC07P129614
  • GC07P129807
  • GC07P130020
  • GC07P124382

Summaries for CPA1 Gene

Entrez Gene Summary for CPA1 Gene

  • This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. This enzyme is produced in the pancreas and preferentially cleaves C-terminal branched-chain and aromatic amino acids from dietary proteins. This gene and several family members are present in a gene cluster on chromosome 7. Mutations in this gene may be linked to chronic pancreatitis, while elevated protein levels may be associated with pancreatic cancer. [provided by RefSeq, Jan 2015]

GeneCards Summary for CPA1 Gene

CPA1 (Carboxypeptidase A1) is a Protein Coding gene. Diseases associated with CPA1 include borna disease and pancreatitis. Among its related pathways are Protein digestion and absorption and Pancreatic secretion. GO annotations related to this gene include metallocarboxypeptidase activity and exopeptidase activity. An important paralog of this gene is CPA3.

UniProtKB/Swiss-Prot for CPA1 Gene

  • Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.

Gene Wiki entry for CPA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPA1 Gene

Genomics for CPA1 Gene

Regulatory Elements for CPA1 Gene

Genomic Location for CPA1 Gene

Chromosome:
7
Start:
130,380,339 bp from pter
End:
130,388,114 bp from pter
Size:
7,776 bases
Orientation:
Plus strand

Genomic View for CPA1 Gene

Genes around CPA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPA1 Gene

Proteins for CPA1 Gene

  • Protein details for CPA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15085-CBPA1_HUMAN
    Recommended name:
    Carboxypeptidase A1
    Protein Accession:
    P15085
    Secondary Accessions:
    • A4D1M1
    • Q53XU0
    • Q9BS67
    • Q9UCF2

    Protein attributes for CPA1 Gene

    Size:
    419 amino acids
    Molecular mass:
    47140 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Monomer. May form a complex with proelastase 2.

    Three dimensional structures from OCA and Proteopedia for CPA1 Gene

neXtProt entry for CPA1 Gene

Proteomics data for CPA1 Gene at MOPED

Post-translational modifications for CPA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPA1 Gene

Antibody Products

  • R&D Systems Antibodies for CPA1 (Carboxypeptidase A1/CPA1)

Domains & Families for CPA1 Gene

Gene Families for CPA1 Gene

Suggested Antigen Peptide Sequences for CPA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15085

UniProtKB/Swiss-Prot:

CBPA1_HUMAN :
  • Belongs to the peptidase M14 family.
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPA1: view

Function for CPA1 Gene

Molecular function for CPA1 Gene

GENATLAS Biochemistry:
carboxypeptidase A1,pancreatic
UniProtKB/Swiss-Prot CatalyticActivity:
Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
UniProtKB/Swiss-Prot Function:
Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.

Enzyme Numbers (IUBMB) for CPA1 Gene

Gene Ontology (GO) - Molecular Function for CPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008238 exopeptidase activity IEA --
genes like me logo Genes that share ontologies with CPA1: view
genes like me logo Genes that share phenotypes with CPA1: view

Human Phenotype Ontology for CPA1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for CPA1 Gene

miRTarBase miRNAs that target CPA1

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CPA1 Gene

Localization for CPA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPA1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPA1 Gene COMPARTMENTS Subcellular localization image for CPA1 gene
Compartment Confidence
extracellular 3
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CPA1 Gene

Pathways & Interactions for CPA1 Gene

genes like me logo Genes that share pathways with CPA1: view

Pathways by source for CPA1 Gene

Interacting Proteins for CPA1 Gene

Gene Ontology (GO) - Biological Process for CPA1 Gene

None

No data available for SIGNOR curated interactions for CPA1 Gene

Drugs & Compounds for CPA1 Gene

(18) Drugs for CPA1 Gene - From: Novoseek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2R)-2-benzyl-3-nitropropanoic acid Experimental Pharma Target 0
(2R)-4,4-dihydroxy-5-nitro-2-(phenylmethyl)pentanoic acid Experimental Pharma Target 0
2-Benzyl-3-Iodopropanoic Acid Experimental Pharma Target 0
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
D-[(Amino)Carbonyl]Phenylalanine Experimental Pharma Target 0

(3) Additional Compounds for CPA1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CPA1: view

Transcripts for CPA1 Gene

Unigene Clusters for CPA1 Gene

Carboxypeptidase A1 (pancreatic):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPA1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^
SP1: - - -
SP2: -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - - -
SP10: - - - - - - - - - -
SP11:
SP12:
SP13:

ExUns: 12a · 12b ^ 13a · 13b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:

Relevant External Links for CPA1 Gene

GeneLoc Exon Structure for
CPA1
ECgene alternative splicing isoforms for
CPA1

Expression for CPA1 Gene

mRNA expression in normal human tissues for CPA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPA1 Gene

This gene is overexpressed in Pancreas (x52.9).

Protein differential expression in normal tissues from HIPED for CPA1 Gene

This gene is overexpressed in Pancreatic juice (60.9) and Pancreas (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CPA1 Gene



SOURCE GeneReport for Unigene cluster for CPA1 Gene Hs.2879

genes like me logo Genes that share expression patterns with CPA1: view

Protein tissue co-expression partners for CPA1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CPA1 Gene

Orthologs for CPA1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CPA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPA1 35
  • 98.81 (n)
  • 99.05 (a)
CPA1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CPA1 36
  • 82 (a)
OneToOne
CPA1 35
  • 86.48 (n)
  • 81.86 (a)
dog
(Canis familiaris)
Mammalia CPA1 35
  • 89.27 (n)
  • 88.86 (a)
CPA1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpa1 36
  • 82 (a)
OneToOne
Cpa1 16
Cpa1 35
  • 83.54 (n)
  • 82.06 (a)
oppossum
(Monodelphis domestica)
Mammalia CPA1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPA1 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpa1 35
  • 83.62 (n)
  • 84.28 (a)
chicken
(Gallus gallus)
Aves CPA1 36
  • 71 (a)
OneToOne
CPA1 35
  • 75 (n)
  • 73.5 (a)
lizard
(Anolis carolinensis)
Reptilia CPA1 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC64526 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cpa1 35
  • 65.67 (n)
  • 67.08 (a)
Str.8435 35
zebrafish
(Danio rerio)
Actinopterygii cpa 35
cpa5 35
  • 67.9 (n)
  • 65.02 (a)
cpa1 36
  • 62 (a)
OneToMany
cpa5 36
  • 64 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta CBPA1_ANOGA 35
  • 51.9 (n)
  • 38.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12374 36
  • 27 (a)
ManyToMany
CG14820 36
  • 32 (a)
ManyToMany
CG17633 36
  • 30 (a)
ManyToMany
CG18417 36
  • 26 (a)
ManyToMany
CG18585 36
  • 35 (a)
ManyToMany
CG2915 36
  • 26 (a)
ManyToMany
CG3097 36
  • 29 (a)
ManyToMany
CG3108 36
  • 11 (a)
ManyToMany
CG32379 36
  • 28 (a)
ManyToMany
CG4017 36
  • 34 (a)
ManyToMany
CG42264 36
  • 18 (a)
ManyToMany
CG4408 36
  • 25 (a)
ManyToMany
CG7025 36
  • 34 (a)
ManyToMany
CG8539 36
  • 24 (a)
ManyToMany
CG8560 36
  • 28 (a)
ManyToMany
CG8562 36
  • 27 (a)
ManyToMany
CG8563 36
  • 29 (a)
ManyToMany
CG8564 36
  • 16 (a)
ManyToMany
CG8945 36
  • 8 (a)
ManyToMany
CG12374 37
  • 29 (a)
CG14820 37
  • 34 (a)
CG15769 37
  • 28 (a)
CG17633 37
  • 33 (a)
CG18415 37
  • 30 (a)
CG18585 37
  • 35 (a)
CG2915 37
  • 28 (a)
CG3097 37
  • 33 (a)
CG3108 37
  • 32 (a)
CG4017 37
  • 33 (a)
CG4408 37
  • 28 (a)
CG7025 37
  • 35 (a)
CG8539 37
  • 29 (a)
CG8560 37
  • 30 (a)
CG8562 37
  • 28 (a)
CG8563 37
  • 34 (a)
CG8945 37
  • 26 (a)
CG17633 35
  • 53.03 (n)
  • 36.04 (a)
worm
(Caenorhabditis elegans)
Secernentea F02D8.4 36
  • 27 (a)
ManyToMany
suro-1 36
  • 19 (a)
ManyToMany
T06A4.1 36
  • 24 (a)
ManyToMany
T06A4.3 36
  • 27 (a)
ManyToMany
W01A8.6 36
  • 27 (a)
ManyToMany
Y18H1A.9 36
  • 31 (a)
ManyToMany
Y47G6A.19 36
  • 27 (a)
ManyToMany
Y59C2A.1 36
  • 29 (a)
ManyToMany
ZC434.9 36
  • 19 (a)
ManyToMany
R11A5.7 37
  • 29 (a)
T06A4.3 37
  • 28 (a)
W01A8.6 37
  • 30 (a)
Y18H1A.9 37
  • 36 (a)
Y47G6A.19 37
  • 31 (a)
Y59C2A.1 37
  • 31 (a)
ZC434.9 37
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM14 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
CSA.11311 36
  • 37 (a)
ManyToMany
CSA.4005 36
  • 21 (a)
ManyToMany
Species with no ortholog for CPA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPA1 Gene

ENSEMBL:
Gene Tree for CPA1 (if available)
TreeFam:
Gene Tree for CPA1 (if available)

Paralogs for CPA1 Gene

Paralogs for CPA1 Gene

(9) SIMAP similar genes for CPA1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CPA1: view

Variants for CPA1 Gene

Sequence variations from dbSNP and Humsavar for CPA1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs34474469 - 130,383,720(+) TCACC(A/G)CCATT reference, missense
rs17849959 - 130,385,185(+) TTACC(A/G)CGGCA reference, missense
rs741486 -- 130,384,169(-) AAAAA(C/T)AGAAG intron-variant
rs741487 -- 130,384,276(-) CCATA(C/G)GATGG intron-variant
rs1126899 -- 130,381,647(+) CGGGG(A/C/G/T)CCTGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CPA1 Gene

Variant ID Type Subtype PubMed ID
esv23964 CNV Gain 19812545
nsv515945 CNV Gain+Loss 19592680

Variation tolerance for CPA1 Gene

Residual Variation Intolerance Score: 86.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 28.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPA1 Gene

HapMap Linkage Disequilibrium report
CPA1
Human Gene Mutation Database (HGMD)
CPA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPA1 Gene

Disorders for CPA1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CPA1 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
borna disease
  • enzootic encephalomyelitis
pancreatitis
pancreatitis, hereditary
  • pancreatitis, chronic
tracheomalacia
  • congenital tracheomalacia
silver-russell syndrome
  • silver russell dwarfism
- elite association - COSMIC cancer census association via MalaCards
Search CPA1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CPA1

Genetic Association Database (GAD)
CPA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPA1
genes like me logo Genes that share disorders with CPA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPA1 Gene

Publications for CPA1 Gene

  1. Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid). (PMID: 18566513) Pallares I. … Vendrell J. (Acta Crystallogr. D 2008) 3 4 23 67
  2. Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2. (PMID: 8806703) Laethem R.M. … Smith G.K. (Arch. Biochem. Biophys. 1996) 3 23
  3. Human carboxypeptidase A identifies a BglII RFLP and maps to 7q31- qter. (PMID: 1969228) Stewart E.A. … Bowcock A.M. (Am. J. Hum. Genet. 1990) 3 23
  4. Genetics of pancreatitis: the 2014 update. (PMID: 24522117) Masamune A. (Tohoku J. Exp. Med. 2014) 3
  5. Variants in CPA1 are strongly associated with early onset chronic pancreatitis. (PMID: 23955596) Witt H. … Sahin-TA^th M. (Nat. Genet. 2013) 3

Products for CPA1 Gene

Sources for CPA1 Gene

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