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Aliases for CPA1 Gene

Aliases for CPA1 Gene

  • Carboxypeptidase A1 2 3 5
  • Carboxypeptidase A1 (Pancreatic) 2 3
  • Pancreatic Carboxypeptidase A 2 3
  • EC 3.4.17.1 4 61
  • CPA 3 4
  • EC 3.4.17 61

External Ids for CPA1 Gene

Previous HGNC Symbols for CPA1 Gene

  • CPA

Previous GeneCards Identifiers for CPA1 Gene

  • GC07P128496
  • GC07P129559
  • GC07P129573
  • GC07P129614
  • GC07P129807
  • GC07P130020
  • GC07P124382

Summaries for CPA1 Gene

Entrez Gene Summary for CPA1 Gene

  • This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. This enzyme is produced in the pancreas and preferentially cleaves C-terminal branched-chain and aromatic amino acids from dietary proteins. This gene and several family members are present in a gene cluster on chromosome 7. Mutations in this gene may be linked to chronic pancreatitis, while elevated protein levels may be associated with pancreatic cancer. [provided by RefSeq, Jan 2015]

GeneCards Summary for CPA1 Gene

CPA1 (Carboxypeptidase A1) is a Protein Coding gene. Diseases associated with CPA1 include Pancreatitis and Borna Disease. Among its related pathways are Protein digestion and absorption and Pancreatic secretion. GO annotations related to this gene include metallocarboxypeptidase activity and exopeptidase activity. An important paralog of this gene is CPA2.

UniProtKB/Swiss-Prot for CPA1 Gene

  • Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.

Gene Wiki entry for CPA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPA1 Gene

Genomics for CPA1 Gene

Regulatory Elements for CPA1 Gene

Enhancers for CPA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F130362 1.6 VISTA FANTOM5 Ensembl ENCODE 52.3 -11.3 -11259 12.7 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 CPA5 CPA1 CPA2 MEST CDC26P1 KLHDC10 ENSG00000273329 CEP41 CPA4 TMEM209
GH07F130409 1 Ensembl ENCODE 12 +29.6 29626 1.6 ZNF362 PKNOX1 ZBTB2 HLF ZBTB11 PBX2 ZBTB17 CPA5 CPA1 MEST CEP41 CPA4 KLHDC10 CPA2 GC07M130398 LOC105375505
GH07F130349 0.9 Ensembl ENCODE 11.9 -28.4 -28359 4.5 HDGF PKNOX1 TBL1XR1 ZFP64 RAD21 YY1 RARA FOS CREM ZNF263 CPA5 MEST CPA1 CPA4 CPA2 COPG2 LOC101928632
GH07F130354 0.8 Ensembl ENCODE 11.9 -22.8 -22779 5.7 PKNOX1 ZNF133 SIN3A FEZF1 GLI4 ZNF2 ZNF121 FOS YY2 REST CPA5 MEST CPA1 KLHDC10 CPA4 CPA2 COPG2 LOC101928632 LOC105375504
GH07F130344 1.3 Ensembl ENCODE 11.8 -34.9 -34893 2.5 ATF1 ZNF76 INSM2 KLF17 ZEB1 ZNF366 ZNF138 ZNF391 FOS CREM CPA5 CPA1 CPA4 ENSG00000270953 LOC101928632
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CPA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CPA1 Gene

Chromosome:
7
Start:
130,380,339 bp from pter
End:
130,388,114 bp from pter
Size:
7,776 bases
Orientation:
Plus strand

Genomic View for CPA1 Gene

Genes around CPA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPA1 Gene

Proteins for CPA1 Gene

  • Protein details for CPA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15085-CBPA1_HUMAN
    Recommended name:
    Carboxypeptidase A1
    Protein Accession:
    P15085
    Secondary Accessions:
    • A4D1M1
    • Q53XU0
    • Q9BS67
    • Q9UCF2

    Protein attributes for CPA1 Gene

    Size:
    419 amino acids
    Molecular mass:
    47140 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Monomer. May form a complex with proelastase 2.

    Three dimensional structures from OCA and Proteopedia for CPA1 Gene

neXtProt entry for CPA1 Gene

Post-translational modifications for CPA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CPA1 Gene

Domains & Families for CPA1 Gene

Gene Families for CPA1 Gene

Suggested Antigen Peptide Sequences for CPA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15085

UniProtKB/Swiss-Prot:

CBPA1_HUMAN :
  • Belongs to the peptidase M14 family.
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPA1: view

Function for CPA1 Gene

Molecular function for CPA1 Gene

GENATLAS Biochemistry:
carboxypeptidase A1,pancreatic
UniProtKB/Swiss-Prot CatalyticActivity:
Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
UniProtKB/Swiss-Prot Function:
Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.

Enzyme Numbers (IUBMB) for CPA1 Gene

Gene Ontology (GO) - Molecular Function for CPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004181 metallocarboxypeptidase activity IEA --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008238 exopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CPA1: view
genes like me logo Genes that share phenotypes with CPA1: view

Human Phenotype Ontology for CPA1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for CPA1

miRNA for CPA1 Gene

miRTarBase miRNAs that target CPA1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CPA1 Gene

Localization for CPA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPA1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPA1 Gene COMPARTMENTS Subcellular localization image for CPA1 gene
Compartment Confidence
extracellular 3
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 2920728
genes like me logo Genes that share ontologies with CPA1: view

Pathways & Interactions for CPA1 Gene

genes like me logo Genes that share pathways with CPA1: view

Pathways by source for CPA1 Gene

Interacting Proteins for CPA1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000011292%0d%0a9606.ENSP00000290122%0d%0a9606.ENSP00000338369%0d%0a9606.ENSP00000365075%0d%0a9606.ENSP00000365116%0d%0a9606.ENSP00000352639%0d%0a
Selected Interacting proteins: ENSP00000011292 P15085-CBPA1_HUMAN for CPA1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with CPA1: view

No data available for SIGNOR curated interactions for CPA1 Gene

Drugs & Compounds for CPA1 Gene

(20) Drugs for CPA1 Gene - From: DrugBank, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2R)-2-benzyl-3-nitropropanoic acid Experimental Pharma Target 0
(2R)-4,4-dihydroxy-5-nitro-2-(phenylmethyl)pentanoic acid Experimental Pharma Target 0
2-Benzyl-3-Iodopropanoic Acid Experimental Pharma Target 0
Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Experimental Pharma Target 0
D-[(Amino)Carbonyl]Phenylalanine Experimental Pharma Target 0

(2) Additional Compounds for CPA1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CPA1 Gene

Compound Action Cas Number
CPA inhibitor Potent carboxypeptidase A (CPA) inhibitor 223532-02-3
genes like me logo Genes that share compounds with CPA1: view

Transcripts for CPA1 Gene

Unigene Clusters for CPA1 Gene

Carboxypeptidase A1 (pancreatic):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CPA1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^
SP1: - - -
SP2: -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - - -
SP10: - - - - - - - - - -
SP11:
SP12:
SP13:

ExUns: 12a · 12b ^ 13a · 13b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:

Relevant External Links for CPA1 Gene

GeneLoc Exon Structure for
CPA1
ECgene alternative splicing isoforms for
CPA1

Expression for CPA1 Gene

mRNA expression in normal human tissues for CPA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPA1 Gene

This gene is overexpressed in Pancreas (x52.9).

Protein differential expression in normal tissues from HIPED for CPA1 Gene

This gene is overexpressed in Pancreatic juice (60.9) and Pancreas (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CPA1 Gene



Protein tissue co-expression partners for CPA1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CPA1 Gene:

CPA1

SOURCE GeneReport for Unigene cluster for CPA1 Gene:

Hs.2879
genes like me logo Genes that share expression patterns with CPA1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CPA1 Gene

Orthologs for CPA1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CPA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CPA1 34 35
  • 98.81 (n)
dog
(Canis familiaris)
Mammalia CPA1 34 35
  • 89.27 (n)
cow
(Bos Taurus)
Mammalia CPA1 34 35
  • 86.48 (n)
rat
(Rattus norvegicus)
Mammalia Cpa1 34
  • 83.62 (n)
mouse
(Mus musculus)
Mammalia Cpa1 34 16 35
  • 83.54 (n)
oppossum
(Monodelphis domestica)
Mammalia CPA1 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPA1 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPA1 34 35
  • 75 (n)
lizard
(Anolis carolinensis)
Reptilia CPA1 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpa1 34
  • 65.67 (n)
Str.8435 34
African clawed frog
(Xenopus laevis)
Amphibia MGC64526 34
zebrafish
(Danio rerio)
Actinopterygii cpa5 34 35
  • 67.9 (n)
cpa1 35
  • 62 (a)
OneToMany
cpa 34
fruit fly
(Drosophila melanogaster)
Insecta CG17633 36 34 35
  • 53.03 (n)
CG18585 36 35
  • 35 (a)
CG7025 36 35
  • 35 (a)
CG14820 36 35
  • 34 (a)
CG8563 36 35
  • 34 (a)
CG3097 36 35
  • 33 (a)
CG4017 36 35
  • 33 (a)
CG3108 36 35
  • 32 (a)
CG18415 36
  • 30 (a)
CG8560 36 35
  • 30 (a)
CG12374 36 35
  • 29 (a)
CG8539 36 35
  • 29 (a)
CG15769 36
  • 28 (a)
CG2915 36 35
  • 28 (a)
CG4408 36 35
  • 28 (a)
CG8562 36 35
  • 28 (a)
CG32379 35
  • 28 (a)
ManyToMany
CG8945 36 35
  • 26 (a)
CG18417 35
  • 26 (a)
ManyToMany
CG42264 35
  • 18 (a)
ManyToMany
CG8564 35
  • 16 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta CBPA1_ANOGA 34
  • 51.9 (n)
worm
(Caenorhabditis elegans)
Secernentea Y18H1A.9 36 35
  • 36 (a)
Y47G6A.19 36 35
  • 31 (a)
Y59C2A.1 36 35
  • 31 (a)
ZC434.9 36 35
  • 31 (a)
W01A8.6 36 35
  • 30 (a)
R11A5.7 36
  • 29 (a)
T06A4.3 36 35
  • 28 (a)
F02D8.4 35
  • 27 (a)
ManyToMany
T06A4.1 35
  • 24 (a)
ManyToMany
suro-1 35
  • 19 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM14 35
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
CSA.11311 35
  • 37 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
CSA.4005 35
  • 21 (a)
ManyToMany
Species where no ortholog for CPA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CPA1 Gene

ENSEMBL:
Gene Tree for CPA1 (if available)
TreeFam:
Gene Tree for CPA1 (if available)

Paralogs for CPA1 Gene

Paralogs for CPA1 Gene

(9) SIMAP similar genes for CPA1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CPA1: view

Variants for CPA1 Gene

Sequence variations from dbSNP and Humsavar for CPA1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1126899 Benign 130,381,647(+) CGGGG(C/G)CCTGC reference, synonymous-codon
rs12706927 Benign 130,383,698(+) GACTA(C/T)GGGCA reference, synonymous-codon
rs201705049 Benign 130,385,141(+) CCCCC(A/C/G)ACAGT intron-variant
rs968404 Benign 130,382,200(+) ATTTA(C/T)GTGCT reference, synonymous-codon
rs10215193 -- 130,387,410(+) AAGGG(A/G)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CPA1 Gene

Variant ID Type Subtype PubMed ID
esv23964 CNV gain 19812545
nsv515945 CNV gain+loss 19592680

Variation tolerance for CPA1 Gene

Residual Variation Intolerance Score: 86.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 28.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPA1 Gene

Human Gene Mutation Database (HGMD)
CPA1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CPA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPA1 Gene

Disorders for CPA1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CPA1 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pancreatitis
borna disease
  • enzootic encephalomyelitis
splenic infarction
  • splenic infarct
pancreatitis, hereditary
  • pancreatitis, chronic
tracheomalacia
  • congenital tracheomalacia
- elite association - COSMIC cancer census association via MalaCards
Search CPA1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CPA1

Genetic Association Database (GAD)
CPA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPA1
genes like me logo Genes that share disorders with CPA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CPA1 Gene

Publications for CPA1 Gene

  1. Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid). (PMID: 18566513) Pallares I. … Vendrell J. (Acta Crystallogr. D 2008) 3 4 22 64
  2. Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2. (PMID: 8806703) Laethem R.M. … Smith G.K. (Arch. Biochem. Biophys. 1996) 3 4 22 64
  3. Human carboxypeptidase A identifies a BglII RFLP and maps to 7q31- qter. (PMID: 1969228) Stewart E.A. … Bowcock A.M. (Am. J. Hum. Genet. 1990) 3 4 22 64
  4. Mammalian metallopeptidase inhibition at the defense barrier of Ascaris parasite. (PMID: 19179285) Sanglas L. … Arolas J.L. (Proc. Natl. Acad. Sci. U.S.A. 2009) 4 22 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for CPA1 Gene

Sources for CPA1 Gene

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