Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CP Gene

protein-coding   GIFtS: 68
GCID: GC03M148880

Ceruloplasmin (Ferroxidase)

  See CP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ceruloplasmin (Ferroxidase)1 2
EC 1.16.3.13 8
CP-22
ceruloplasmin2
Ferroxidase3

External Ids:    HGNC: 22951   Entrez Gene: 13562   Ensembl: ENSG000000474577   OMIM: 1177005   UniProtKB: P004503   

Export aliases for CP gene to outside databases

Previous GC identifers: GC03M145840 GC03M149776 GC03M150161 GC03M150212 GC03M150211 GC03M150374 GC03M146261


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CP Gene:
The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in
the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia,
which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic
abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for
this gene. (provided by RefSeq, Feb 2012)

GeneCards Summary for CP Gene:
CP (ceruloplasmin (ferroxidase)) is a protein-coding gene. Diseases associated with CP include cerebellar ataxia, and aceruloplasminemia. GO annotations related to this gene include copper ion binding and ferroxidase activity. An important paralog of this gene is HEPHL1.

UniProtKB/Swiss-Prot: CERU_HUMAN, P00450
Function: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase
activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport
across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan
sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By
similarity)

Gene Wiki entry for CP (Ceruloplasmin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CP gene promoter:
         TBP   AP-1   ATF-2   Pax-2   Pax-2a   XBP-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCP promoter sequence
   Search Chromatin IP Primers for CP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q23-q25   Ensembl cytogenetic band:  3q25.1   HGNC cytogenetic band: 3q23-q25

CP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CP gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M148880:  view genomic region     (about GC identifiers)

Start:
148,880,197 bp from pter      End:
148,939,842 bp from pter
Size:
59,646 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CERU_HUMAN, P00450 (See protein sequence)
Recommended Name: Ceruloplasmin precursor  
Size: 1065 amino acids; 122205 Da
Cofactor: Binds 6 copper ions per monomer
4 PDB 3D structures from and Proteopedia for CP:
1KCW (3D)        2J5W (3D)        4EJX (3D)        4ENZ (3D)    
Secondary accessions: Q14063 Q2PP18 Q9UKS4

Explore the universe of human proteins at neXtProt for CP: NX_P00450

Explore proteomics data for CP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys906
  • Glycosylation2 at Asn138, Asn358, Asn397, Ser492, Asn588, Asn762, Asn926
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CP (P00450) (see all 10)
     YKKVVYR  YYSAVDP  HLGILGP  HCHVTDH 


    See CP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000087.1  
    ENSEMBL proteins: 
     ENSP00000418773   ENSP00000420367   ENSP00000264613   ENSP00000420545   ENSP00000426888  
    Reactome Protein details: P00450

    CP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for CP
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CP
    GenScript Custom Purified and Recombinant Proteins Services for CP
    Novus Biologicals CP Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CP

     
    Search eBioscience for Proteins for CP 

    CP Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CP
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CP
    OriGene Custom Antibody Services for CP
    Novus Biologicals CP Antibodies
    Abcam antibodies for CP
    Cloud-Clone Corp. Antibodies for CP
    ThermoFisher Antibodies for CP
    LSBio Antibodies in human, mouse, rat for CP

    CP Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CP
    Cloud-Clone Corp. CLIAs for CP
    Search eBioscience for ELISAs for CP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 6):
     IPR011707 Cu-oxidase_3
     IPR027150 CP
     IPR011706 Cu-oxidase_2
     IPR008972 Cupredoxin
     IPR002355 Cu_oxidase_Cu_BS

    Graphical View of Domain Structure for InterPro Entry P00450

    ProtoNet protein and cluster: P00450

    2 Blocks protein domains:
    IPB001117 Multicopper oxidase
    IPB011706 Multicopper oxidase


    UniProtKB/Swiss-Prot: CERU_HUMAN, P00450
    Similarity: Belongs to the multicopper oxidase family
    Similarity: Contains 3 F5/8 type A domains
    Similarity: Contains 6 plastocyanin-like domains


    Find genes that share domains with CP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CERU_HUMAN, P00450
    Function: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase
    activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport
    across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan
    sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By
    similarity)
    Catalytic activity: 4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O

         Genatlas biochemistry entry for CP:
    ceruloplasmin (130kDa),alpha-2-glycoprotein,with retinal and glial cell specific expression,essential for iron
    homeostasis and neuronal survival

         Enzyme Number (IUBMB): EC 1.16.3.11 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004322ferroxidase activity IEA--
    GO:0005507copper ion binding IEA--
    GO:0016491oxidoreductase activity ----
    GO:0051087chaperone binding IPI19996109
         
    Find genes that share ontologies with CP           About GenesLikeMe


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Cp):
     behavior/neurological  cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  nervous system  pigmentation  vision/eye 

    Find genes that share phenotypes with CP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CP: Cptm1Yos Cptm1Hrs Cptm1Samd

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CP

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CP using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CP:
    hsa-miR-33a* hsa-miR-520d-5p hsa-miR-15b* hsa-miR-524-5p hsa-miR-3157-5p
    SwitchGear 3'UTR luciferase reporter plasmidCP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CP
    Predesigned siRNA for gene silencing in human, mouse, rat CP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CP

    Clone
    Products:
         
    OriGene clones in human, mouse for CP (see all 6)
    OriGene ORF clones in mouse, rat for CP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for CP
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CP

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CP
    Browse ESI BIO Cell Lines and PureStem Progenitors for CP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CERU_HUMAN, P00450: Secreted. Note=Colocalizes with GCP1 in secretory intracellular compartments (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol2
    endoplasmic reticulum2
    golgi apparatus2
    mitochondrion2
    nucleus2
    plasma membrane2
    cytoskeleton1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA19996109
    GO:0005765lysosomal membrane IDA17897319
    GO:0070062extracellular vesicular exosome IDA19056867
    GO:0072562blood microparticle IDA--

    Find genes that share ontologies with CP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CP About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47
    2Insulin receptor recycling
    Iron uptake and transport0.70
    3Metabolism of porphyrins
    Porphyrin and chlorophyll metabolism0.56
    4NOD-like Receptor Signaling Pathways
    Immune response IL 1 signaling pathway0.42
    5Mechanisms of CFTR activation by S nitrosoglutathione normal and CF
    Mechanisms of CFTR activation by S nitrosoglutathione normal and CF 0.37


    Find genes that share SuperPaths with CP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for CP
        Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Immune response IL-1 signaling pathway

    1 BioSystems Pathway for CP
        HIF-1-alpha transcription factor network

    2 Reactome Pathways for CP
        Iron uptake and transport
    Metal ion SLC transporters


    1 Kegg Pathway  (Kegg details for CP):
        Porphyrin and chlorophyll metabolism

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CP: 
              Nephrotoxicity in human mouse rat
              Lung Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for CP (P004503 ENSP000002646134) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MPOP051643, ENSP000002252754I2D: score=2 STRING: ENSP00000225275
    SLC40A1Q9NP593, ENSP000002610244I2D: score=2 STRING: ENSP00000261024
    ATP7AQ046563, ENSP000003457284I2D: score=1 STRING: ENSP00000345728
    PROCP040703, ENSP000002340714I2D: score=1 STRING: ENSP00000234071
    GASTP013503, ENSP000003313584I2D: score=1 STRING: ENSP00000331358
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006825copper ion transport IEA--
    GO:0006879cellular iron ion homeostasis TAS--
    GO:0055085transmembrane transport TAS--
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with CP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CP (CERU)

    4 HMDB Compounds for CP    About this table
    CompoundSynonyms CAS #PubMed Ids
    CopperCu (see all 2)7440-50-8--
    IronArmco iron (see all 19)7439-89-6--
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for CP    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Drotrecogin alfaAnticoagulant protein C (see all 4)60202-16-6target--17016423 17139284

    Selected Novoseek inferred chemical compound relationships for CP gene (see all 108)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    copper 91 1304 2002050 (7), 17697957 (7), 11580917 (7), 16252197 (7) (see all 99)
    iron 82.7 745 16806171 (8), 16475160 (8), 10777486 (7), 11019827 (6) (see all 99)
    o-dianisidine dihydrochloride 78.8 2 10949969 (1), 15668637 (1)
    d penicillamine 72.7 7 8615370 (1), 1370162 (1), 8221705 (1), 8162007 (1) (see all 6)
    tetrathiomolybdate 72.6 8 10656425 (2), 12738719 (2), 12545680 (1), 19595438 (1) (see all 5)
    superoxide 70.3 170 1649082 (6), 12480800 (4), 12924803 (3), 9612901 (2) (see all 99)
    copper histidine 70 4 1616932 (1), 10400645 (1), 15902551 (1)
    apotransferrin 66.8 10 9210294 (2), 9247149 (2), 7951057 (1), 1742318 (1) (see all 6)
    malondialdehyde 64.9 127 9855215 (5), 15207835 (3), 15372879 (3), 18553110 (3) (see all 59)
    stellacyanin 64.3 4 15212551 (1), 17804076 (1), 1793005 (1), 10550695 (1)



    Find genes that share compounds with CP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CP gene: 
    NM_000096.3  

    Unigene Cluster for CP:

    Ceruloplasmin (ferroxidase)
    Hs.558314  [show with all ESTs]
    Unigene Representative Sequence: NM_000096
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481169 ENST00000479771 ENST00000460674(uc003eww.4) ENST00000264613(uc011bnr.2 uc003ewx.4 uc003ewy.4 uc003ewz.3)
    ENST00000494544 ENST00000474204 ENST00000473296 ENST00000463556 ENST00000490639
    ENST00000497902 ENST00000462336 ENST00000489736(uc010hvf.1) ENST00000497797
    ENST00000471356 ENST00000455472
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CP using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CP:
    hsa-miR-33a* hsa-miR-520d-5p hsa-miR-15b* hsa-miR-524-5p hsa-miR-3157-5p
    SwitchGear 3'UTR luciferase reporter plasmidCP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CP
    Predesigned siRNA for gene silencing in human, mouse, rat CP
    Clone
    Products:
         
    OriGene clones in human, mouse for CP (see all 6)
    OriGene ORF clones in mouse, rat for CP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for CP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CP
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CP
      QuantiTect SYBR Green Assays in human, mouse, rat CP
      QuantiFast Probe-based Assays in human, mouse, rat CP

    Additional mRNA sequence: 

    AK095290.1 AK291219.1 AK299272.1 AK309279.1 BC039239.1 BC061702.1 BC070304.1 BC094709.1 
    BC142714.1 BC146663.1 BC146801.1 BX647327.1 M13536.1 M13699.1 NR_046371.1 X04135.1 
    X04136.1 X04137.1 X04138.1 X69706.1 

    Selected DOTS entries (see all 27):

    DT.120917730  DT.40253489  DT.451537  DT.95368343  DT.75102599  DT.100645314  DT.100828135  DT.409489 
    DT.95368345  DT.99938433  DT.100035622  DT.101978061  DT.40106072  DT.40113246  DT.75139281  DT.100037817 
    DT.95265921  DT.95265924  DT.100037816  DT.100828131  DT.120917721  DT.120917775  DT.121472397  DT.97781982 

    Selected AceView cDNA sequences (see all 440):

    T39961 BM856196 AA603131 BM706008 AA872345 CB305427 BM693027 BG533467 
    BU738514 CD723929 AI985661 CA393024 BM914294 AI288268 BG618879 BE392045 
    CD252024 AU134073 AI922198 AW440530 AI648426 BQ574900 CA396025 BG564741 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CP (see all 14)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a ·
    SP1:                                                                                -                                                                           
    SP2:                                                                                -                                                                           
    SP3:                                                                                -                                                                           
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 17b ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c ^ 23a · 23b
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for CP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCCAACAA
    CP Expression
    About this image


    CP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Late Floor Plate Cells Mesencephalic Floor Plate
             Diencephalic Roof Plate
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
             Oligodendrocyte-like cells
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
    CP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.558314

    UniProtKB/Swiss-Prot: CERU_HUMAN, P00450
    Tissue specificity: Expressed by the liver and secreted in plasma

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CP: 
              Nephrotoxicity in human mouse rat
              Lung Cancer in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CP
    QuantiTect SYBR Green Assays in human, mouse, rat CP
    QuantiFast Probe-based Assays in human, mouse, rat CP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for CP gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cp1 , 5 ceruloplasmin1, 5 84.18(n)1
    83.65(a)1
      3 (6.10 cM)5
    128701  NM_001276248.11  NP_001263177.11 
     199570545 
    chicken
    (Gallus gallus)
    Aves CP1 ceruloplasmin (ferroxidase) 67.02(n)
    61.6(a)
      771940  XM_001235148.3  XP_001235149.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    70(a)
    61(a)
    many → 1
    many → 1
    AAWZ02041447(3315-5643)
    3(19046295-19074760)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cp1 ceruloplasmin (ferroxidase) 63.34(n)
    57.74(a)
      100492836  XM_002937329.2  XP_002937375.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cp2 ceruloplasmin 75.7(n)   84702  BC048037.1 


    ENSEMBL Gene Tree for CP (if available)
    TreeFam Gene Tree for CP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CP gene
    HEPHL12  HEPH2  
    7 SIMAP similar genes for CP using alignment to 7 protein entries:     CERU_HUMAN (see all proteins):
    factor V    HEPHL1    F8c    F8C    HEPH    F8
    F5

    Find genes that share paralogs with CP           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for CP
    PGOHUM00000237811 PGOHUM00000250263 PGOHUM00000249743


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CP (see all 1539)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1396333881,2
    C,Funtested1148879202(+) GGGGGC/GCAATT 3 A G mis12Minor allele frequency- G:0.00NA EU 5431
    rs1457849491,2
    C,Funtested1148885959(+) CTGCCG/ACCTGC 3 /R /W mis11Minor allele frequency- A:0.00NA 4550
    rs617334581,2
    C,Funtested1148899031(+) GCCCAG/ATGAAT 3 /T /I mis13Minor allele frequency- A:0.02NS NA EU 5911
    rs2006834331,2
    Cuntested1148913218(+) TTCATC/GTGTGT 3 H D mis11Minor allele frequency- G:0.00EU 1235
    rs30706071,2
    C--146282076(+) CACAC-/AC    
       
    /ACAC
    GCATA
    2 -- int10--------
    rs342392801,2
    C--146285807(+) AAAGT-/AAAAAA 2 -- int10--------
    rs3701239051,2
    C--146291678(+) TGTTT-/GTCTTTTT 2 -- int10--------
    rs730190151,2
    C,F--148862565(+) GTAAGA/GCAGTC 1 -- int13Minor allele frequency- G:0.13WA CSA 122
    rs616150921,2
    C,F--148862684(+) TCTAAA/GATGGA 1 -- int18Minor allele frequency- G:0.45WA NA CSA EA 372
    rs579432581,2
    C,F--148862689(+) AATGGA/GCAATC 1 -- int15Minor allele frequency- G:0.22WA NA EA 362

    HapMap Linkage Disequilibrium report for CP (148880197 - 148939842 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv269498CNV Insertion20981092
    esv273611CNV Insertion20981092
    nsv4055CNV Loss18451855
    nsv528012CNV Loss19592680
    nsv877639CNV Gain21882294

    Human Gene Mutation Database (HGMD): CP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CP
    DNA2.0 Custom Variant and Variant Library Synthesis for CP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 117700   
    OMIM disorders: 604290  
    UniProtKB/Swiss-Prot: CERU_HUMAN, P00450
  • Aceruloplasminemia (ACERULOP) [MIM:604290]: An autosomal recessive disorder of iron metabolism
    characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the
    triad of retinal degeneration, diabetes mellitus and neurological disturbances. Note=The disease is caused by
    mutations affecting the gene represented in this entry
  • Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into
    ceruloplasmin in liver because of defects in the copper-transporting ATPase 2

  • Selected diseases for CP (see all 28):    
    About MalaCards
    cerebellar ataxia    aceruloplasminemia    hemosiderosis    thyroid gland disease
    pneumoconiosis    swayback    boutonneuse fever    wilson disease
    athetosis    neuroacanthocytosis    desmoplastic infantile ganglioglioma    pili torti
    toxic oil syndrome    hair disease    granulocytopenia    granulosa cell tumor of the ovary
    fascioliasis    eales disease    menkes disease    prostatitis

    11 diseases from the University of Copenhagen DISEASES database for CP:
    Wilson disease     Aceruloplasminemia     Menkes disease     Anemia
    Liver cirrhosis     Hepatitis     Autosomal recessive disease     Brain disease
    Swayback     Neurodegenerative disease     Hemochromatosis

    Find genes that share disorders with CP           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CP gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wilson disease 90.6 108 16644258 (5), 1883396 (3), 15607310 (3), 18845768 (2) (see all 68)
    menkes disease 81.8 7 1638075 (1), 15122050 (1), 9396570 (1), 11040994 (1) (see all 6)
    hypercupremia 77.9 1 16815276 (1)
    response acute phase 70.6 20 10471781 (2), 8305889 (1), 1725175 (1), 10320628 (1) (see all 16)
    pili torti 70.3 2 1638075 (1), 17651950 (1)
    iron overload 67.3 36 12200392 (2), 17541408 (2), 11076887 (1), 16806171 (1) (see all 16)
    retinal degeneration 55.6 9 9438577 (2), 16639025 (1), 17065470 (1), 12724641 (1) (see all 7)
    anemia, hypochromic microcytic 49.4 1 20190976 (1)
    hemochromatosis 49 7 11783942 (1), 16797509 (1), 10520410 (1), 15105274 (1) (see all 5)
    inflammation 45.1 46 15781823 (3), 16267389 (2), 16629165 (2), 8425718 (2) (see all 35)

    Genatlas disease: CP
    hypoceruloplasminemia severe with progressive late-onset neurodegenerative syndrome of dysarthria,gait
    disturbance,non insulin-dependent diabetes mellitus,sytemic hemosiderosis

    GeneTests: CP
    GeneReviews: CP
    Genetic Association Database (GAD): CP
    Human Genome Epidemiology (HuGE) Navigator: CP (756 documents)

    Export disorders for CP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CP gene, integrated from 10 sources (see all 1224):
    (articles sorted by number of sources associating them with CP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ceruloplasmin gene variations and substantia nigra hyperechogenicity in Parkinson disease. (PubMed id 15557511)1, 2, 4, 9 Hochstrasser H.... Berg D. (Neurology 2004)
    2. Human ceruloplasmin. Tissue-specific expression of transcripts produced by alternative splicing. (PubMed id 2355023)1, 2, 9 Yang F.M.... Bowman B.H. (J. Biol. Chem. 1990)
    3. Functional relevance of ceruloplasmin mutations in Parkinson's disease. (PubMed id 16150804)1, 2, 9 Hochstrasser H.... Berg D. (FASEB J. 2005)
    4. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Dorak M.T. (Mol. Hum. Reprod. 2010)
    5. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
    6. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    7. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    8. Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PubMed id 14760718)1, 2 Bunkenborg J.... Wisniewski J.R. (Proteomics 2004)
    9. A proteomic analysis of human bile. (PubMed id 15084671)1, 2 Kristiansen T.Z.... Pandey A. (Mol. Cell. Proteomics 2004)
    10. Phenotype and allele frequencies of some serum protein polymorphisms in populations of the Balkans. (PubMed id 15648851)1, 4 Scheil H.G....Huckenbeck W. ( Bericht ├╝ber die biologisch-anthropologische Literatur 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1356 HGNC: 2295 AceView: CP Ensembl:ENSG00000047457 euGenes: HUgn1356
    ECgene: CP Kegg: 1356 H-InvDB: CP

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CP Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=CP[genesymbol]
    Wikipedia http://en.wikipedia.org/wiki/Ceruloplasmin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CP gene:
    Search GeneIP for patents involving CP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CP
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CP   OriGene RNAi products in human, mouse, rat for CP  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CP  
     OriGene qSTAR qPCR primer pairs in human, mouse for CP   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CP   OriGene Custom Protein Services for CP  

     
     
     Block miRNA regulation of human, mouse, rat CP using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CP
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CP Predesigned siRNA for gene silencing in human, mouse, rat CP
     QuantiFast Probe-based Assays in human, mouse, rat CP QuantiTect SYBR Green Assays in human, mouse, rat CP
     PCR Arrays including human, mouse, rat CP Search Chromatin IP Primers for CP
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CP  GeneGlobe Interaction Network for CP
     Regulatory tfbs in CP promoter
     GenScript Custom Purified and Recombinant Proteins Services for CP GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for CP
     GenScript Custom Assay Services for CP GenScript Custom overexpressing Cell Line Services for CP
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CP (CERU)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for CP
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CP antibodies
     CP proteins
     Antibodies for CP
     See all of Abcam's Antibodies, Kits and Proteins for CP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CP
     Antibodies for CP
     ELISAs for CP
     CLIAs for CP



     Browse ESI BIO Cell Lines and PureStem Progenitors for CP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CP
     SwitchGear 3'UTR luciferase reporter plasmids for CP
     SwitchGear Promoter luciferase reporter plasmids for CP
     ThermoFisher Antibodies for CP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CP
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CP
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CP
     LSBio Antibodies in human, mouse, rat for CP
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for CP
      Search eBioscience for proteins for CP
      Search eBioscience for elisas for CP
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CP gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4