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Aliases for COX8C Gene

Aliases for COX8C Gene

  • Cytochrome C Oxidase Subunit VIIIC 2 3
  • Cytochrome C Oxidase Subunit 8-3 3 4
  • COX VIII-3 3 4
  • Cytochrome C Oxidase Polypeptide VIII Isoform 3 4
  • Cytochrome C Oxidase Polypeptide 8 Isoform 3 4
  • Cytochrome C Oxidase Subunit VIII Isoform 3 2
  • Cytochrome C Oxidase Polypeptide VIII 3
  • Cytochrome C Oxidase Polypeptide 8 3
  • Cytochrome C Oxidase Subunit VIII 3
  • Cytochrome C Oxidase Subunit 8C 2
  • COX8-3 3

External Ids for COX8C Gene

Previous GeneCards Identifiers for COX8C Gene

  • GC14P091803
  • GC14P092883
  • GC14P093813
  • GC14P073993

Summaries for COX8C Gene

GeneCards Summary for COX8C Gene

COX8C (Cytochrome C Oxidase Subunit VIIIC) is a Protein Coding gene. Among its related pathways are Metabolism and AMPK Enzyme Complex Pathway. GO annotations related to this gene include cytochrome-c oxidase activity.

UniProtKB/Swiss-Prot for COX8C Gene

  • This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX8C Gene

Genomics for COX8C Gene

Regulatory Elements for COX8C Gene

Genomic Location for COX8C Gene

Chromosome:
14
Start:
93,347,191 bp from pter
End:
93,348,356 bp from pter
Size:
1,166 bases
Orientation:
Plus strand

Genomic View for COX8C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COX8C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX8C Gene

Proteins for COX8C Gene

  • Protein details for COX8C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4L0-COX8C_HUMAN
    Recommended name:
    Cytochrome c oxidase subunit 8C, mitochondrial
    Protein Accession:
    Q7Z4L0
    Secondary Accessions:
    • Q495K7

    Protein attributes for COX8C Gene

    Size:
    72 amino acids
    Molecular mass:
    8129 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX8C Gene

Proteomics data for COX8C Gene at MOPED

Post-translational modifications for COX8C Gene

No Post-translational modifications

Other Protein References for COX8C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COX8C Gene

Domains & Families for COX8C Gene

Protein Domains for COX8C Gene

Suggested Antigen Peptide Sequences for COX8C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z4L0

UniProtKB/Swiss-Prot:

COX8C_HUMAN :
  • Belongs to the cytochrome c oxidase VIII family.
Family:
  • Belongs to the cytochrome c oxidase VIII family.
genes like me logo Genes that share domains with COX8C: view

Function for COX8C Gene

Molecular function for COX8C Gene

UniProtKB/Swiss-Prot Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Gene Ontology (GO) - Molecular Function for COX8C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 cytochrome-c oxidase activity IBA --
genes like me logo Genes that share ontologies with COX8C: view
genes like me logo Genes that share phenotypes with COX8C: view

Animal Model Products

miRNA for COX8C Gene

miRTarBase miRNAs that target COX8C

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COX8C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for COX8C Gene

Localization for COX8C Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX8C Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COX8C Gene COMPARTMENTS Subcellular localization image for COX8C gene
Compartment Confidence
mitochondrion 5

Gene Ontology (GO) - Cellular Components for COX8C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 12762575
GO:0005743 mitochondrial inner membrane --
GO:0005751 mitochondrial respiratory chain complex IV IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with COX8C: view

Pathways & Interactions for COX8C Gene

genes like me logo Genes that share pathways with COX8C: view

Pathways by source for COX8C Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Mitochondrial Energy Metabolism in human,mouse,rat

Interacting Proteins for COX8C Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000340568%0d%0a9606.ENSP00000321260%0d%0a
Selected Interacting proteins: ENSP00000340568 for COX8C Gene via STRING

Symbol External ID(s) Details
COX8A

Gene Ontology (GO) - Biological Process for COX8C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen IBA --
GO:1902600 hydrogen ion transmembrane transport IBA --
genes like me logo Genes that share ontologies with COX8C: view

No data available for SIGNOR curated interactions for COX8C Gene

Drugs & Compounds for COX8C Gene

(2) Additional Compounds for COX8C Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with COX8C: view

Transcripts for COX8C Gene

mRNA/cDNA for COX8C Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for COX8C Gene

Cytochrome c oxidase subunit VIIIC:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COX8C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COX8C Gene

No ASD Table

Relevant External Links for COX8C Gene

GeneLoc Exon Structure for
COX8C
ECgene alternative splicing isoforms for
COX8C

Expression for COX8C Gene

mRNA expression in normal human tissues for COX8C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COX8C Gene

This gene is overexpressed in Testis (x45.2).

SOURCE GeneReport for Unigene cluster for COX8C Gene Hs.666459

mRNA Expression by UniProt/SwissProt for COX8C Gene

Q7Z4L0-COX8C_HUMAN
Tissue specificity: It is not yet known where COX8C is expressed
genes like me logo Genes that share expression patterns with COX8C: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for COX8C Gene

Orthologs for COX8C Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for COX8C Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Cox8c 16
chimpanzee
(Pan troglodytes)
Mammalia COX8C 36
  • 89 (a)
OneToOne
Species with no ortholog for COX8C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for COX8C Gene

ENSEMBL:
Gene Tree for COX8C (if available)
TreeFam:
Gene Tree for COX8C (if available)

Paralogs for COX8C Gene

(2) SIMAP similar genes for COX8C Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for COX8C Gene

genes like me logo Genes that share paralogs with COX8C: view

No data available for Paralogs for COX8C Gene

Variants for COX8C Gene

Variation tolerance for COX8C Gene

Residual Variation Intolerance Score: 65.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.75; 33.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COX8C Gene

HapMap Linkage Disequilibrium report
COX8C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for COX8C Gene

Disorders for COX8C Gene

Relevant External Links for COX8C

Genetic Association Database (GAD)
COX8C
Human Genome Epidemiology (HuGE) Navigator
COX8C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COX8C
genes like me logo Genes that share disorders with COX8C: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX8C Gene

Publications for COX8C Gene

  1. A third isoform of cytochrome c oxidase subunit VIII is present in mammals. (PMID: 12909344) Huettemann M. … Grossman L.I. (Gene 2003) 2 67
  2. HIV-1 Tat protein directly induces mitochondrial membrane permeabilization and inactivates cytochrome c oxidase. (PMID: 22419111) Lecoeur H. … Jacotot E. (Cell Death Dis 2012) 67
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Genetic aspects of susceptibility to air pollution. (PMID: 12762575) Kleeberger S.R. (Eur Respir J Suppl 2003) 67

Products for COX8C Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Mitochondrial Energy Metabolism in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate COX8C
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for COX8C
    • Block miRNA regulation of COX8C using miScript Target Protectors

    Sources for COX8C Gene

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