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Aliases for COX8C Gene

Aliases for COX8C Gene

  • Cytochrome C Oxidase Subunit 8C 2 3 5
  • Cytochrome C Oxidase Subunit VIIIC 2 3 4
  • Cytochrome C Oxidase Subunit 8-3 3 4
  • COX VIII-3 3 4
  • COX8-3 3 4
  • Cytochrome C Oxidase Polypeptide VIII Isoform 3 4
  • Cytochrome C Oxidase Subunit 8C, Mitochondrial 3
  • Cytochrome C Oxidase Polypeptide 8 Isoform 3 4
  • Cytochrome C Oxidase Subunit VIII Isoform 3 2
  • Cytochrome C Oxidase Polypeptide VIII 3
  • Cytochrome C Oxidase Polypeptide 8 3
  • Cytochrome C Oxidase Subunit VIII 3

External Ids for COX8C Gene

Previous GeneCards Identifiers for COX8C Gene

  • GC14P091803
  • GC14P092883
  • GC14P093813
  • GC14P073993

Summaries for COX8C Gene

GeneCards Summary for COX8C Gene

COX8C (Cytochrome C Oxidase Subunit 8C) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and AMPK Enzyme Complex Pathway. GO annotations related to this gene include cytochrome-c oxidase activity.

UniProtKB/Swiss-Prot for COX8C Gene

  • This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX8C Gene

Genomics for COX8C Gene

Regulatory Elements for COX8C Gene

Enhancers for COX8C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G093322 1.3 Ensembl ENCODE dbSUPER 11.3 -23.4 -23413 2.1 HDAC1 CTCF PKNOX1 BACH1 RAD21 ZNF316 SCRT2 NFE2 MAFK EZH2 COX8C UNC79 OTUB2 UBR7 BTBD7 ENSG00000241499
GH14G093298 1.3 Ensembl ENCODE dbSUPER 11 -44.2 -44202 9.4 PKNOX1 ZSCAN4 FEZF1 ZNF2 ZNF121 SCRT2 FOS ZNF362 ZEB2 NR2F2 BTBD7 UNC79 COX8C UBR7 ENSG00000241499
GH14G093316 1.2 Ensembl ENCODE dbSUPER 10.8 -29.3 -29254 3.1 SIX4 JUN BACH1 CHD7 ZNF664 ZNF316 GATA3 NFE2 FOS MAFK COX8C BTBD7 UNC79 ENSG00000241499
GH14G093375 1.1 FANTOM5 ENCODE 10.8 +28.8 28816 1.5 PKNOX1 TBL1XR1 WRNIP1 BMI1 CBX5 ZNF143 RELB IKZF2 CREM JUNB COX8C RNU6-1258P BTBD7 UNC79 GC14M093398 ENSG00000202306
GH14G093368 1 Ensembl ENCODE 11.7 +22.6 22552 1.5 RELA ARID3A EED ZNF207 ETV6 RELB IKZF2 SRF STAT1 MTA2 COX8C RNU6-1258P BTBD7 ITPK1 GC14M093398 ENSG00000202306
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around COX8C on UCSC Golden Path with GeneCards custom track

Genomic Location for COX8C Gene

Chromosome:
14
Start:
93,347,191 bp from pter
End:
93,348,356 bp from pter
Size:
1,166 bases
Orientation:
Plus strand

Genomic View for COX8C Gene

Genes around COX8C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX8C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX8C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX8C Gene

Proteins for COX8C Gene

  • Protein details for COX8C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4L0-COX8C_HUMAN
    Recommended name:
    Cytochrome c oxidase subunit 8C, mitochondrial
    Protein Accession:
    Q7Z4L0
    Secondary Accessions:
    • Q495K7

    Protein attributes for COX8C Gene

    Size:
    72 amino acids
    Molecular mass:
    8129 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX8C Gene

Post-translational modifications for COX8C Gene

No Post-translational modifications

Other Protein References for COX8C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COX8C Gene

Domains & Families for COX8C Gene

Protein Domains for COX8C Gene

Suggested Antigen Peptide Sequences for COX8C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z4L0

UniProtKB/Swiss-Prot:

COX8C_HUMAN :
  • Belongs to the cytochrome c oxidase VIII family.
Family:
  • Belongs to the cytochrome c oxidase VIII family.
genes like me logo Genes that share domains with COX8C: view

Function for COX8C Gene

Molecular function for COX8C Gene

UniProtKB/Swiss-Prot Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Gene Ontology (GO) - Molecular Function for COX8C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 cytochrome-c oxidase activity IBA --
genes like me logo Genes that share ontologies with COX8C: view
genes like me logo Genes that share phenotypes with COX8C: view

Animal Model Products

CRISPR Products

miRNA for COX8C Gene

miRTarBase miRNAs that target COX8C

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COX8C Gene

Localization for COX8C Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX8C Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COX8C gene
Compartment Confidence
mitochondrion 5
extracellular 2

Gene Ontology (GO) - Cellular Components for COX8C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 12762575
GO:0005743 mitochondrial inner membrane IEA --
GO:0005751 mitochondrial respiratory chain complex IV IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with COX8C: view

Pathways & Interactions for COX8C Gene

genes like me logo Genes that share pathways with COX8C: view

Pathways by source for COX8C Gene

Interacting Proteins for COX8C Gene

Gene Ontology (GO) - Biological Process for COX8C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen IBA --
GO:1902600 hydrogen ion transmembrane transport IBA --
genes like me logo Genes that share ontologies with COX8C: view

No data available for SIGNOR curated interactions for COX8C Gene

Drugs & Compounds for COX8C Gene

(2) Drugs for COX8C Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with COX8C: view

Transcripts for COX8C Gene

mRNA/cDNA for COX8C Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for COX8C Gene

Cytochrome c oxidase subunit VIIIC:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for COX8C Gene

No ASD Table

Relevant External Links for COX8C Gene

GeneLoc Exon Structure for
COX8C
ECgene alternative splicing isoforms for
COX8C

Expression for COX8C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COX8C Gene

mRNA differential expression in normal tissues according to GTEx for COX8C Gene

This gene is overexpressed in Testis (x45.2).

NURSA nuclear receptor signaling pathways regulating expression of COX8C Gene:

COX8C

SOURCE GeneReport for Unigene cluster for COX8C Gene:

Hs.666459

mRNA Expression by UniProt/SwissProt for COX8C Gene:

Q7Z4L0-COX8C_HUMAN
Tissue specificity: It is not yet known where COX8C is expressed.
genes like me logo Genes that share expression patterns with COX8C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for COX8C Gene

Orthologs for COX8C Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for COX8C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COX8C 35
  • 89 (a)
OneToOne
Species where no ortholog for COX8C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for COX8C Gene

ENSEMBL:
Gene Tree for COX8C (if available)
TreeFam:
Gene Tree for COX8C (if available)

Paralogs for COX8C Gene

(2) SIMAP similar genes for COX8C Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for COX8C Gene

genes like me logo Genes that share paralogs with COX8C: view

No data available for Paralogs for COX8C Gene

Variants for COX8C Gene

Sequence variations from dbSNP and Humsavar for COX8C Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1003634299 -- 93,348,162(+) AAACT(C/T)TCAGA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1003963761 -- 93,346,168(+) CTACA(G/T)CAAAA intron-variant, upstream-variant-2KB
rs1005694353 -- 93,348,551(+) TTTAT(A/G)TTCTA intron-variant, nc-transcript-variant, downstream-variant-500B
rs1007716748 -- 93,346,071(+) ATTTA(A/C)ATGGA intron-variant, upstream-variant-2KB
rs1008311054 -- 93,347,599(+) GTCGT(C/T)GGGCA intron-variant

Variation tolerance for COX8C Gene

Residual Variation Intolerance Score: 65.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.75; 33.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COX8C Gene

Human Gene Mutation Database (HGMD)
COX8C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
COX8C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for COX8C Gene

Disorders for COX8C Gene

Relevant External Links for COX8C

Genetic Association Database (GAD)
COX8C
Human Genome Epidemiology (HuGE) Navigator
COX8C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COX8C

No disorders were found for COX8C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX8C Gene

Publications for COX8C Gene

  1. A third isoform of cytochrome c oxidase subunit VIII is present in mammals. (PMID: 12909344) Huettemann M. … Grossman L.I. (Gene 2003) 2 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. HIV-1 Tat protein directly induces mitochondrial membrane permeabilization and inactivates cytochrome c oxidase. (PMID: 22419111) Lecoeur H. … Jacotot E. (Cell Death Dis 2012) 3 64
  5. Genetic aspects of susceptibility to air pollution. (PMID: 12762575) Kleeberger S.R. (Eur Respir J Suppl 2003) 3 64

Products for COX8C Gene

Sources for COX8C Gene

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