COX8C Gene
protein-coding GIFtS: 41
GCID: GC14P093813
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cytochrome c oxidase subunit VIIIC(Previous name: cytochrome c oxidase subunit 8C )
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Aliases
for COX8C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cytochrome C Oxidase Subunit VIIIC1 2 | | Cytochrome C Oxidase Polypeptide VIII2 | | COX8-31 2 | | Cytochrome C Oxidase Subunit 8C, Mitochondrial2 | | Cytochrome C Oxidase Subunit 8-32 3 | | Cytochrome C Oxidase Subunit VIII2 | | COX VIII-32 3 | | Cytochrome C Oxidase Polypeptide 8 Isoform 33 | | Cytochrome C Oxidase Subunit 8C1 | | Cytochrome C Oxidase Polypeptide VIII Isoform 33 | | Cytochrome C Oxidase Polypeptide 82 | | |
Export aliases for COX8C gene to outside databasesPrevious GC identifers: GC14P091803 GC14P092883 GC14P073993 |
Summaries
for COX8C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: COX8C_HUMAN, Q7Z4L0Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase inmitochondrial electron transport
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Genomic Views
for COX8C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the COX8C gene promoter:
TBP Spz1 Sp1 LUN-1 GATA-1 MEF-2A HSF2 aMEF-2 TGIF Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for COX8C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COX8C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.12 Ensembl cytogenetic band: 14q32.12 HGNC cytogenetic band: 14q32.13COX8C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P093813: view genomic region
(about GC identifiers)
Start:
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93,813,537 bp from pter |
End:
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93,814,702 bp from pter |
Size:
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1,166 bases |
Orientation:
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plus strand |
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Proteins
for COX8C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: COX8C_HUMAN, Q7Z4L0 (See
protein sequence)Recommended Name: Cytochrome c oxidase subunit 8C, mitochondrial precursor Size: 72 amino acids; 8129 Da
Subcellular location: Mitochondrion inner membrane
Secondary accessions: Q495K7Explore the universe of human proteins at neXtProt for COX8C: NX_Q7Z4L0
COX8C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_892016.1
ENSEMBL proteins: ENSP00000340568
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
COX8C for ontologies About GeneDecksing
COX8C Antibody Products:
Assay Products for COX8C: |
Protein
Domains /
Families
for COX8C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
COX8C for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7Z4L0ProtoNet protein and cluster: Q7Z4L0 1 Blocks protein family: IPB003205 Cytochrome oxidase c
UniProtKB/Swiss-Prot: COX8C_HUMAN, Q7Z4L0Similarity: Belongs to the cytochrome c oxidase VIII family |
Function
for COX8C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: COX8C_HUMAN, Q7Z4L0Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase inmitochondrial electron transport
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COX8C (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COX8C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: COX8C (NM_182971) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COX8C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX8C |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004129 | cytochrome-c oxidase activity |
IEA | -- |
COX8C for ontologies About GeneDecksing
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Pathways & Interactions
for COX8C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 2 | Cardiac muscle contraction | | | 3 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/6 
Kegg Pathways (Kegg details for COX8C) (see all 6):
COX8C for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COX8C
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Drugs & Compounds
for COX8C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for COX8C
2 HMDB Compounds for COX8C About this table
Search CenterWatch for drugs/clinical trials and news about COX8C
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Transcripts
for COX8C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for COX8C gene: NM_182971.2 Unigene Cluster for COX8C: Cytochrome c oxidase subunit VIIIC Hs.666459 [show with all ESTs]Unigene Representative Sequence: AY1610041 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000342144(uc001ybt.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COX8C (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COX8C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: COX8C (NM_182971) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COX8C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX8C |
Additional cDNA sequence: AY161004.1 BC101125.2 BC101126.2 1 DOTS entry: DT.40127627 12 AceView cDNA sequences: AW182519 BE466670 AI217106 AI217104 NM_182971 AW269756 AY161004 AA983928 AW104540 AW173010 AW269746 AI808907
GeneLoc Exon Structure
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Expression
for COX8C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| COX8C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTATGATGA
About this image
See COX8C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COX8C
SOURCE GeneReport for Unigene cluster: Hs.666459
UniProtKB/Swiss-Prot: COX8C_HUMAN, Q7Z4L0Tissue specificity: It is not yet known where COX8C is expressed
SABiosciences Expression via Pathway-Focused PCR Array including COX8C: | Mitochondrial Energy Metabolism in human mouse rat |
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat COX8C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COX8C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COX8C |
Orthologs
for COX8C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for COX8C gene from 1 species (see representative species ) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Cox8c5 |
cytochrome c oxidase, subunit VIIIc |
-- |
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12 (52.55 cM) 102899306 |
ENSEMBL Gene Tree for COX8C (if available)
TreeFam Gene Tree for COX8C (if available) |
Paralogs
for COX8C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for COX8C gene
2 SIMAP similar genes for COX8C using alignment to 1 protein entry: COX8C_HUMAN:COX8 COX8A
COX8C for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for COX8C
PGOHUM00000243106 PGOHUM00000235964 PGOHUM00000245313
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Genomic Variants
for COX8C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COX8C |
|
Disorders
/ Diseases
for COX8C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
COX8C for disorders About GeneDecksing
2  diseases for COX8C: About MalaCardshuntington's disease parkinson's disease
Human Genome Epidemiology (HuGE) Navigator: COX8C (1 document)
Export disorders for COX8C gene to outside databases
|
Publications
for COX8C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for COX8C gene integrated from 9 sources:
(articles sorted by number of sources associating them with COX8C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A third isoform of cytochrome c oxidase subunit VIII is present in mammals. (PubMed id 12909344)1, 2, 3 Huettemann M.... Grossman L.I. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- HIV-1 Tat protein directly induces mitochondrial membr ane permeabilization and inactivates cytochrome c oxidase. (PubMed id 22419111)1 Lecoeur H....Jacotot E. (2012)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Genetic aspects of susceptibility to air pollution. (PubMed id 12762575)1 Kleeberger S.R. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for COX8C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing COX8C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing COX8C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COX8C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for COX8C | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for COX8C gene:
Search GeneIP for patents involving COX8C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for COX8C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for COX8C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COX8C | | Browse OriGene genome-wide validated SYBR primer pairs | | | OriGene Protein Over-expression Lysate for COX8C | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for COX8C | | OriGene 3'-UTR Clone for COX8C | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COX8C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COX8C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for COX8C | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for COX8C | | OriGene Custom Protein Services for COX8C | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COX8C | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COX8C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COX8C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COX8C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COX8C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COX8C |
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 |  |  |  | |
| | | | Search Tocris compounds for COX8C |
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 | | | COX8C Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for COX8C |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX8C |
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