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Aliases for COX8A Gene

Aliases for COX8A Gene

  • Cytochrome C Oxidase Subunit 8A 2 3
  • Cytochrome C Oxidase Subunit VIIIA (Ubiquitous) 2 3 5
  • Cytochrome C Oxidase Polypeptide VIII-Liver/Heart 3 4
  • Cytochrome C Oxidase Subunit VIII 2 3
  • Cytochrome C Oxidase Subunit 8-2 3 4
  • COX8L 3 4
  • COX8 3 4
  • Cytochrome C Oxidase Subunit 8A (Ubiquitous) 3
  • COX8-2 3
  • VIII-L 3
  • VIII 3
  • COX 3

External Ids for COX8A Gene

Previous HGNC Symbols for COX8A Gene

  • COX8

Previous GeneCards Identifiers for COX8A Gene

  • GC11P063518
  • GC11P063498
  • GC11P063742
  • GC11P060070

Summaries for COX8A Gene

Entrez Gene Summary for COX8A Gene

  • The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. [provided by RefSeq, Jul 2008]

GeneCards Summary for COX8A Gene

COX8A (Cytochrome C Oxidase Subunit 8A) is a Protein Coding gene. Diseases associated with COX8A include mitochondrial complex iv deficiency and isolated cytochrome c oxidase deficiency. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include cytochrome-c oxidase activity. An important paralog of this gene is ENSG00000256100.

UniProtKB/Swiss-Prot for COX8A Gene

  • This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX8A Gene

Genomics for COX8A Gene

Regulatory Elements for COX8A Gene

Promoters for COX8A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COX8A on UCSC Golden Path with GeneCards custom track

Genomic Location for COX8A Gene

Chromosome:
11
Start:
63,974,607 bp from pter
End:
63,976,543 bp from pter
Size:
1,937 bases
Orientation:
Plus strand

Genomic View for COX8A Gene

Genes around COX8A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX8A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX8A Gene

Proteins for COX8A Gene

  • Protein details for COX8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10176-COX8A_HUMAN
    Recommended name:
    Cytochrome c oxidase subunit 8A, mitochondrial
    Protein Accession:
    P10176
    Secondary Accessions:
    • P15955

    Protein attributes for COX8A Gene

    Size:
    69 amino acids
    Molecular mass:
    7579 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX8A Gene

Proteomics data for COX8A Gene at MOPED

Post-translational modifications for COX8A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COX8A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COX8A Gene

Domains & Families for COX8A Gene

Protein Domains for COX8A Gene

Suggested Antigen Peptide Sequences for COX8A Gene

Graphical View of Domain Structure for InterPro Entry

P10176

UniProtKB/Swiss-Prot:

COX8A_HUMAN :
  • Belongs to the cytochrome c oxidase VIII family.
Family:
  • Belongs to the cytochrome c oxidase VIII family.
genes like me logo Genes that share domains with COX8A: view

Function for COX8A Gene

Molecular function for COX8A Gene

UniProtKB/Swiss-Prot Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
genes like me logo Genes that share phenotypes with COX8A: view

Animal Model Products

miRNA for COX8A Gene

miRTarBase miRNAs that target COX8A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COX8A Gene

Localization for COX8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX8A Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COX8A Gene COMPARTMENTS Subcellular localization image for COX8A gene
Compartment Confidence
mitochondrion 5
cytosol 1
extracellular 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for COX8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005751 mitochondrial respiratory chain complex IV IBA --
genes like me logo Genes that share ontologies with COX8A: view

Pathways & Interactions for COX8A Gene

genes like me logo Genes that share pathways with COX8A: view

Gene Ontology (GO) - Biological Process for COX8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen IBA,TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0098779 mitophagy in response to mitochondrial depolarization IGI 22020285
genes like me logo Genes that share ontologies with COX8A: view

No data available for SIGNOR curated interactions for COX8A Gene

Drugs & Compounds for COX8A Gene

(2) Drugs for COX8A Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cholic acid Approved Pharma Full agonist, Agonist, Target 0
N-Formylmethionine Experimental Pharma Target 0

(2) Additional Compounds for COX8A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with COX8A: view

Transcripts for COX8A Gene

mRNA/cDNA for COX8A Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1333) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for COX8A Gene

Cytochrome c oxidase subunit VIIIA (ubiquitous):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COX8A Gene

No ASD Table

Relevant External Links for COX8A Gene

GeneLoc Exon Structure for
COX8A
ECgene alternative splicing isoforms for
COX8A

Expression for COX8A Gene

mRNA expression in normal human tissues for COX8A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for COX8A Gene

This gene is overexpressed in Nasal epithelium (39.8) and Hair follicle (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for COX8A Gene



SOURCE GeneReport for Unigene cluster for COX8A Gene Hs.743989

genes like me logo Genes that share expression patterns with COX8A: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for COX8A Gene

Orthologs for COX8A Gene

This gene was present in the common ancestor of mammals.

Orthologs for COX8A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COX8A 35
  • 98.55 (n)
  • 98.55 (a)
COX8A 36
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia COX8A 36
  • 72 (a)
OneToMany
LOC783202 35
  • 80.68 (n)
  • 73.91 (a)
dog
(Canis familiaris)
Mammalia COX8A 35
  • 80.19 (n)
  • 69.57 (a)
-- 36
  • 65 (a)
ManyToMany
COX8A 36
  • 68 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Cox8a 16
Cox8a 36
  • 67 (a)
OneToMany
Cox8a 35
  • 78.74 (n)
  • 68.12 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 44 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cox8a 35
  • 76.81 (n)
  • 66.67 (a)
Species with no ortholog for COX8A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for COX8A Gene

ENSEMBL:
Gene Tree for COX8A (if available)
TreeFam:
Gene Tree for COX8A (if available)

Paralogs for COX8A Gene

Paralogs for COX8A Gene

(2) SIMAP similar genes for COX8A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with COX8A: view

Variants for COX8A Gene

Sequence variations from dbSNP and Humsavar for COX8A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1187867 -- 63,973,737(+) caatc(C/T)cggct upstream-variant-2KB
rs1803315 -- 63,976,374(+) CCATC(C/T)TGGTC utr-variant-3-prime
rs7130187 -- 63,974,702(+) CGCTG(C/T)TGCTG reference, synonymous-codon
rs10751004 -- 63,974,038(+) ACCTC(A/T)GATGA upstream-variant-2KB
rs10897469 -- 63,973,876(+) GTTGG(C/T)CAGTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for COX8A Gene

Variant ID Type Subtype PubMed ID
dgv1155n71 CNV Loss 21882294
dgv1156n71 CNV Loss 21882294
nsv897639 CNV Loss 21882294
esv29993 CNV Loss 17803354

Variation tolerance for COX8A Gene

Residual Variation Intolerance Score: 60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COX8A Gene

HapMap Linkage Disequilibrium report
COX8A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX8A Gene

Disorders for COX8A Gene

MalaCards: The human disease database

(2) MalaCards diseases for COX8A Gene - From: ClinVar and Orphanet

Disorder Aliases PubMed IDs
mitochondrial complex iv deficiency
  • cytochrome-c oxidase deficiency disease
isolated cytochrome c oxidase deficiency
  • isolated cox deficiency
- elite association - COSMIC cancer census association via MalaCards
Search COX8A in MalaCards View complete list of genes associated with diseases

Relevant External Links for COX8A

Genetic Association Database (GAD)
COX8A
Human Genome Epidemiology (HuGE) Navigator
COX8A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COX8A
genes like me logo Genes that share disorders with COX8A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for COX8A Gene

Publications for COX8A Gene

  1. A gene specifying subunit VIII of human cytochrome c oxidase is localized to chromosome 11 and is expressed in both muscle and non- muscle tissues. (PMID: 2543673) Rizzuto R. … Schon E.A. (J. Biol. Chem. 1989) 2 3 4 67
  2. A third isoform of cytochrome c oxidase subunit VIII is present in mammals. (PMID: 12909344) Huettemann M. … Grossman L.I. (Gene 2003) 3 23
  3. The Protein Data Bank. (PMID: 10592235) Berman H.M. … Bourne P.E. (Nucleic Acids Res. 2000) 25 26
  4. Human heart cytochrome c oxidase subunit VIII. Purification and determination of the complete amino acid sequence. (PMID: 2847943) van Kuilenburg A.B.P. … van Beeumen J.J. (FEBS Lett. 1988) 2 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for COX8A Gene

Sources for COX8A Gene

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