COX8A Gene
protein-coding GIFtS: 52
GCID: GC11P063742
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cytochrome c oxidase subunit VIIIA (ubiquitous)(Previous names: cytochrome c oxidase subunit VIII, cytochrome c oxidase...)
(Previous symbol: COX8)
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Aliases
for COX8A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cytochrome C Oxidase Subunit VIIIA (Ubiquitous)1 2 | | VIII-L1 2 | | COX81 2 3 5 | | Cytochrome C Oxidase Subunit 8A (Ubiquitous)1 2 | | COX8L1 2 3 | | Cytochrome C Oxidase Subunit VIII1 2 | | COX1 2 | | Cytochrome C Oxidase Polypeptide VIII-Liver/Heart2 3 | | COX8-21 2 | | Cytochrome C Oxidase Subunit 8-22 3 | | VIII1 2 | | Cytochrome C Oxidase Subunit 8A, Mitochondrial2 |
Export aliases for COX8A gene to outside databasesPrevious GC identifers: GC11P063518 GC11P063498 GC11P060070 |
Summaries
for COX8A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for COX8A:
The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electronsfrom cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across theinner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function,the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 inmammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalyticfunction. This gene encodes one of the nuclear-encoded subunits. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: COX8A_HUMAN, P10176Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase inmitochondrial electron transport
|
Genomic Views
for COX8A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the COX8A gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B2 Olf-1 POU2F2 AREB6 POU2F1 POU2F1a POU2F2B Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for COX8A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COX8A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q12-q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q12-q13COX8A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P063742: view genomic region
(about GC identifiers)
Start:
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63,742,079 bp from pter |
End:
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63,744,015 bp from pter |
Size:
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1,937 bases |
Orientation:
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plus strand |
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Proteins
for COX8A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: COX8A_HUMAN, P10176 (See
protein sequence)Recommended Name: Cytochrome c oxidase subunit 8A, mitochondrial precursor Size: 69 amino acids; 7579 Da
Subcellular location: Mitochondrion inner membrane
Secondary accessions: P15955Explore the universe of human proteins at neXtProt for COX8A: NX_P10176
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P10176
COX8A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004065.1
ENSEMBL proteins: ENSP00000321260 Reactome Protein details: P10176
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
COX8A for ontologies About GeneDecksing
COX8A Antibody Products:
Assay Products for COX8A: |
Protein
Domains /
Families
for COX8A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
COX8A for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P10176ProtoNet protein and cluster: P10176 1 Blocks protein family: IPB003205 Cytochrome oxidase c
UniProtKB/Swiss-Prot: COX8A_HUMAN, P10176Similarity: Belongs to the cytochrome c oxidase VIII family |
Function
for COX8A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: COX8A_HUMAN, P10176Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase inmitochondrial electron transport
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COX8A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COX8A
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Synthesis Service for COX8A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX8A |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004129 | cytochrome-c oxidase activity |
IEA | -- |
COX8A for ontologies About GeneDecksing
|
Pathways & Interactions
for COX8A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 2 | Metabolism | | | 3 | Cardiac muscle contraction | | | 4 | Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for COX8A
4 
Reactome Pathways for COX8A
5/6 
Kegg Pathways (Kegg details for COX8A) (see all 6):
COX8A for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COX8A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 23)
5/23 Interacting proteins for COX8A (ENSP000003212604) via UniProtKB, MINT, STRING, and/or I2D (see all 23)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006091 | generation of precursor metabolites and energy |
TAS | 2543673 | | GO:0022904 | respiratory electron transport chain |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
COX8A for ontologies About GeneDecksing
|
Drugs & Compounds
for COX8A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for COX8A
2 HMDB Compounds for COX8A About this table
2 DrugBank Compounds for COX8A About this table
Search CenterWatch for drugs/clinical trials and news about COX8A
|
Transcripts
for COX8A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for COX8A gene: NM_004074.2 Unigene Cluster for COX8A: Cytochrome c oxidase subunit VIIIA (ubiquitous) Hs.743989 [show with all ESTs]Unigene Representative Sequence: CD5559871 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000314133(uc001nye.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COX8A (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COX8A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: COX8A (NM_004074) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COX8A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX8A |
Additional cDNA sequence: AK311934.1 BC000501.1 BC063025.1 BT009803.1 CR407687.1 18 DOTS entries: DT.101971358 DT.100886580 DT.100045241 DT.120741946 DT.91673279 DT.100045240 DT.100886564 DT.219944 DT.100886572 DT.100886573 DT.100886558 DT.120741959 DT.100886562 DT.120741903 DT.120741910 DT.95149702 DT.95333829 DT.97856606 24/1333 AceView cDNA sequences (see all 1333): BQ027343 BG326513 AA380475 BU857744 F29044 F26706 CR620541 BI759987 BG683128 CR609784 BF038997 AY177200 AI571351 F25631 AW162410 CR617783 BM707585 BQ218109 BG820247 BF873267 BE887772 BU857217 BU162844 AI097371
GeneLoc Exon Structure
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Expression
for COX8A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| COX8A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGACCTCCT
About this image
See COX8A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COX8A
SOURCE GeneReport for Unigene cluster: Hs.743989
SABiosciences Expression via Pathway-Focused PCR Arrays including COX8A:
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COX8A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COX8A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COX8A |
Orthologs
for COX8A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for COX8A gene from 1/5 species (see all 5) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Cox8a1 , 5 |
cytochrome c oxidase, subunit VIIIa5
cytochrome c oxidase subunit VIIIa1 |
78.74(n)1
68.12(a)1 |
|
19 (5.28 cM)5
128681 NM_007750.21 NP_031776.11
72151585 |
ENSEMBL Gene Tree for COX8A (if available)
TreeFam Gene Tree for COX8A (if available) |
Paralogs
for COX8A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for COX8A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for COX8A (63742079 - 63744015 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for COX8A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COX8A |
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Disorders
/ Diseases
for COX8A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
COX8A for disorders About GeneDecksing
OMIM gene information: 123870
OMIM disorders: --
5  diseases for COX8A: About MalaCardshepatitis c huntington's disease parkinson's disease hepatitis
pancreatitis
1 disease from the University of Copenhagen DISEASES database for COX8A:Malignant glioma Human Genome Epidemiology (HuGE) Navigator: COX8A (1 document)
Export disorders for COX8A gene to outside databases
|
Publications
for COX8A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for COX8A gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with COX8A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A gene specifying subunit VIII of human cytochrome c oxidase is localized to chromosome 11 and is expressed in both muscle and non- muscle tissues. (PubMed id 2543673)1, 2, 3 Rizzuto R.... Schon E.A. (1989)
- Human heart cytochrome c oxidase subunit VIII. Purification and determination of the complete amino acid sequence. (PubMed id 2847943)1, 2, 3 van Kuilenburg A.B.P....van Beeumen J.J. (1988)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A third isoform of cytochrome c oxidase subunit VIII is present in mammals. (PubMed id 12909344)1, 9 Huettemann M.... Grossman L.I. (2003)
- HIV-1 Tat protein directly induces mitochondrial membr ane permeabilization and inactivates cytochrome c oxidase. (PubMed id 22419111)1 Lecoeur H....Jacotot E. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (2000)
- Peptide nucleic acid delivery to human mitochondria. (PubMed id 10637443)1 Chinnery P.F....Lightowlers R.N. (1999)
|
External Searches for COX8A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing COX8A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing COX8A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COX8A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for COX8A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for COX8A gene:
Search GeneIP for patents involving COX8A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for COX8A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for COX8A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COX8A | | Browse OriGene genome-wide validated SYBR primer pairs | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for COX8A | | OriGene 3'-UTR Clone for COX8A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COX8A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COX8A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for COX8A | | OriGene Custom Protein Services for COX8A | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COX8A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COX8A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COX8A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COX8A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COX8A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COX8A |
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| | | | Search Tocris compounds for COX8A |
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 | | | COX8A Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for COX8A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX8A |
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