Free for academic non-profit institutions. Other users need a Commercial license

Aliases for COX8A Gene

Aliases for COX8A Gene

  • Cytochrome C Oxidase Subunit 8A 2 3 5
  • Cytochrome C Oxidase Polypeptide VIII-Liver/Heart 3 4
  • Cytochrome C Oxidase Subunit VIIIA (Ubiquitous) 2 3
  • Cytochrome C Oxidase Subunit VIII 2 3
  • Cytochrome C Oxidase Subunit 8-2 3 4
  • COX8L 3 4
  • COX8 3 4
  • Cytochrome C Oxidase Subunit 8A, Mitochondrial 3
  • Cytochrome C Oxidase Subunit 8A (Ubiquitous) 3
  • COX8-2 3
  • VIII-L 3
  • VIII 3
  • COX 3

External Ids for COX8A Gene

Previous HGNC Symbols for COX8A Gene

  • COX8

Previous GeneCards Identifiers for COX8A Gene

  • GC11P063518
  • GC11P063498
  • GC11P063742
  • GC11P060070

Summaries for COX8A Gene

Entrez Gene Summary for COX8A Gene

  • The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. [provided by RefSeq, Jul 2008]

GeneCards Summary for COX8A Gene

COX8A (Cytochrome C Oxidase Subunit 8A) is a Protein Coding gene. Diseases associated with COX8A include Mitochondrial Complex Iv Deficiency and Leigh-Like Syndrome. Among its related pathways are Arachidonate Epoxygenase / Epoxide Hydrolase and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include cytochrome-c oxidase activity. An important paralog of this gene is ENSG00000256100.

UniProtKB/Swiss-Prot for COX8A Gene

  • This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX8A Gene

Genomics for COX8A Gene

Regulatory Elements for COX8A Gene

Enhancers for COX8A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G063944 1.2 Ensembl ENCODE 12.4 -29.2 -29176 2.3 RB1 ARID4B DEAF1 THRB RAD21 RARA ZNF143 RELB EGR2 THAP11 ENSG00000256100 RNU6-45P COX8A RNU6-1306P ENSG00000256341 OTUB1 NAA40 GC11P063971
GH11G064152 1.2 Ensembl ENCODE 11 +178.9 178946 1.7 ARID4B DMAP1 ZNF143 DEK SP3 NFYC REST SSRP1 MIER3 ETV4 TRMT112 TRPT1 STIP1 ENSG00000256341 FLRT1 COX8A ENSG00000256100 RNU6-45P ENSG00000256481 FERMT3
GH11G063950 1 Ensembl ENCODE 12.4 -22.7 -22697 2.3 WRNIP1 ASH2L MAX EBF1 POLR2A NFYB EED SCRT2 ZNF143 RELB ENSG00000256100 COX8A MARK2 RNU6-1306P C11orf84 MACROD1 ENSG00000256481 ENSG00000256341 ENSG00000257086 PLCB3
GH11G064156 0.8 ENCODE dbSUPER 11 +182.2 182177 0.2 CTCF TFAP4 SAP130 POLR2A SMARCA4 HNRNPL STIP1 ENSG00000256341 FLRT1 ENSG00000256100 COX8A RNU6-45P ENSG00000256481 FERMT3 MARK2 ENSG00000256116
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around COX8A on UCSC Golden Path with GeneCards custom track

Promoters for COX8A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for COX8A Gene

63,974,607 bp from pter
63,976,543 bp from pter
1,937 bases
Plus strand

Genomic View for COX8A Gene

Genes around COX8A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX8A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX8A Gene

Proteins for COX8A Gene

  • Protein details for COX8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome c oxidase subunit 8A, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • P15955

    Protein attributes for COX8A Gene

    69 amino acids
    Molecular mass:
    7579 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX8A Gene

Post-translational modifications for COX8A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COX8A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COX8A Gene

Domains & Families for COX8A Gene

Protein Domains for COX8A Gene

Suggested Antigen Peptide Sequences for COX8A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome c oxidase VIII family.
  • Belongs to the cytochrome c oxidase VIII family.
genes like me logo Genes that share domains with COX8A: view

Function for COX8A Gene

Molecular function for COX8A Gene

UniProtKB/Swiss-Prot Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Gene Ontology (GO) - Molecular Function for COX8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 cytochrome-c oxidase activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with COX8A: view
genes like me logo Genes that share phenotypes with COX8A: view

Animal Model Products

CRISPR Products

miRNA for COX8A Gene

miRTarBase miRNAs that target COX8A

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for COX8A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COX8A Gene

Localization for COX8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX8A Gene

Mitochondrion inner membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COX8A gene
Compartment Confidence
mitochondrion 5
plasma membrane 1
extracellular 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for COX8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005751 mitochondrial respiratory chain complex IV IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with COX8A: view

Pathways & Interactions for COX8A Gene

genes like me logo Genes that share pathways with COX8A: view

Gene Ontology (GO) - Biological Process for COX8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy TAS 2543673
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen TAS --
GO:1902600 hydrogen ion transmembrane transport IEA,IBA --
genes like me logo Genes that share ontologies with COX8A: view

No data available for SIGNOR curated interactions for COX8A Gene

Drugs & Compounds for COX8A Gene

(4) Drugs for COX8A Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cholic acid Approved Pharma Full agonist, Agonist, Target 0
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
N-Formylmethionine Experimental Pharma Target 0
genes like me logo Genes that share compounds with COX8A: view

Transcripts for COX8A Gene

mRNA/cDNA for COX8A Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1333) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for COX8A Gene

Cytochrome c oxidase subunit VIIIA (ubiquitous):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for COX8A

Alternative Splicing Database (ASD) splice patterns (SP) for COX8A Gene

No ASD Table

Relevant External Links for COX8A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COX8A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COX8A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for COX8A Gene

This gene is overexpressed in Nasal epithelium (39.8) and Hair follicle (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for COX8A Gene

NURSA nuclear receptor signaling pathways regulating expression of COX8A Gene:


SOURCE GeneReport for Unigene cluster for COX8A Gene:


Evidence on tissue expression from TISSUES for COX8A Gene

  • Heart(4.7)
  • Pancreas(4.5)
  • Liver(4.4)
  • Nervous system(4.1)
  • Muscle(3.3)
  • Lung(3.2)
  • Eye(3.1)
  • Blood(2.3)
  • Kidney(2.3)
  • Stomach(2.2)
  • Thyroid gland(2.1)
  • Adrenal gland(2)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with COX8A: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for COX8A Gene

Orthologs for COX8A Gene

This gene was present in the common ancestor of mammals.

Orthologs for COX8A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COX8A 34 35
  • 98.55 (n)
(Bos Taurus)
Mammalia LOC783202 34
  • 80.68 (n)
COX8A 35
  • 72 (a)
(Canis familiaris)
Mammalia COX8A 34 35
  • 80.19 (n)
-- 35
  • 65 (a)
(Mus musculus)
Mammalia Cox8a 34 16 35
  • 78.74 (n)
(Rattus norvegicus)
Mammalia Cox8a 34
  • 76.81 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 44 (a)
Species where no ortholog for COX8A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for COX8A Gene

Gene Tree for COX8A (if available)
Gene Tree for COX8A (if available)

Paralogs for COX8A Gene

Paralogs for COX8A Gene

(2) SIMAP similar genes for COX8A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with COX8A: view

Variants for COX8A Gene

Sequence variations from dbSNP and Humsavar for COX8A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs869025575 Pathogenic 63,976,224(+) GTGTA(C/G)GAATT splice-acceptor-variant
rs1001707448 -- 63,976,386(+) TGTTA(A/C)TGCAT utr-variant-3-prime
rs1002159789 -- 63,976,994(+) TTTTT(-/C)TTTTT downstream-variant-500B
rs1003160916 -- 63,975,289(+) TTCTC(C/T)TGCCT intron-variant
rs1005259418 -- 63,972,788(+) GAGGC(A/G)GAGGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for COX8A Gene

Variant ID Type Subtype PubMed ID
esv29993 CNV loss 17803354
nsv1042075 CNV loss 25217958
nsv555181 CNV loss 21841781
nsv951010 CNV deletion 24416366

Variation tolerance for COX8A Gene

Residual Variation Intolerance Score: 60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COX8A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX8A Gene

Disorders for COX8A Gene

MalaCards: The human disease database

(3) MalaCards diseases for COX8A Gene - From: ClinVar, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
mitochondrial complex iv deficiency
  • cytochrome-c oxidase deficiency disease
leigh-like syndrome
cardiomyopathy, hypertrophic, 4
  • hypertrophic cardiomyopathy 4
- elite association - COSMIC cancer census association via MalaCards
Search COX8A in MalaCards View complete list of genes associated with diseases

Relevant External Links for COX8A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with COX8A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for COX8A Gene

Publications for COX8A Gene

  1. A gene specifying subunit VIII of human cytochrome c oxidase is localized to chromosome 11 and is expressed in both muscle and non- muscle tissues. (PMID: 2543673) Rizzuto R. … Schon E.A. (J. Biol. Chem. 1989) 2 3 4 64
  2. Human heart cytochrome c oxidase subunit VIII. Purification and determination of the complete amino acid sequence. (PMID: 2847943) van Kuilenburg A.B.P. … van Beeumen J.J. (FEBS Lett. 1988) 2 3 4 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. A third isoform of cytochrome c oxidase subunit VIII is present in mammals. (PMID: 12909344) Huettemann M. … Grossman L.I. (Gene 2003) 3 22 64

Products for COX8A Gene

  • Addgene plasmids for COX8A

Sources for COX8A Gene

Loading form....