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Aliases for COX8A Gene

Aliases for COX8A Gene

  • Cytochrome C Oxidase Subunit VIIIA (Ubiquitous) 2 3
  • COX8 3 4 6
  • Cytochrome C Oxidase Polypeptide VIII-Liver/Heart 3 4
  • Cytochrome C Oxidase Subunit 8A (Ubiquitous) 2 3
  • Cytochrome C Oxidase Subunit VIII 2 3
  • Cytochrome C Oxidase Subunit 8-2 3 4
  • COX8L 3 4
  • Cytochrome C Oxidase Subunit 8A, Mitochondrial 3
  • COX8-2 3
  • VIII-L 3
  • VIII 3
  • COX 3

External Ids for COX8A Gene

Previous HGNC Symbols for COX8A Gene

  • COX8

Previous GeneCards Identifiers for COX8A Gene

  • GC11P063518
  • GC11P063498
  • GC11P063742
  • GC11P060070

Summaries for COX8A Gene

Entrez Gene Summary for COX8A Gene

  • The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. [provided by RefSeq, Jul 2008]

GeneCards Summary for COX8A Gene

COX8A (Cytochrome C Oxidase Subunit VIIIA (Ubiquitous)) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include cytochrome-c oxidase activity. An important paralog of this gene is ENSG00000256100.

UniProtKB/Swiss-Prot for COX8A Gene

  • This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX8A Gene

Genomics for COX8A Gene

Regulatory Elements for COX8A Gene

Genomic Location for COX8A Gene

63,974,607 bp from pter
63,976,543 bp from pter
1,937 bases
Plus strand

Genomic View for COX8A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COX8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX8A Gene

Proteins for COX8A Gene

  • Protein details for COX8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome c oxidase subunit 8A, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • P15955

    Protein attributes for COX8A Gene

    69 amino acids
    Molecular mass:
    7579 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX8A Gene

Proteomics data for COX8A Gene at MOPED

Post-translational modifications for COX8A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COX8A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for COX8A Gene

Domains for COX8A Gene

Gene Families for COX8A Gene

  • comIV :Mitochondrial respiratory chain complex / Complex IV

Protein Domains for COX8A Gene

Suggested Antigen Peptide Sequences for COX8A Gene

Graphical View of Domain Structure for InterPro Entry



  • P10176
  • Belongs to the cytochrome c oxidase VIII family.
genes like me logo Genes that share domains with COX8A: view

Function for COX8A Gene

Molecular function for COX8A Gene

UniProtKB/Swiss-Prot Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Gene Ontology (GO) - Molecular Function for COX8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 cytochrome-c oxidase activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with COX8A: view

miRNA for COX8A Gene

miRTarBase miRNAs that target COX8A

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for COX8A Gene

Localization for COX8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX8A Gene

Mitochondrion inner membrane.

Subcellular locations from

Jensen Localization Image for COX8A Gene COMPARTMENTS Subcellular localization image for COX8A gene
Compartment Confidence
mitochondrion 5
cytosol 1
extracellular 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for COX8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with COX8A: view

Pathways for COX8A Gene

genes like me logo Genes that share pathways with COX8A: view

Gene Ontology (GO) - Biological Process for COX8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006091 generation of precursor metabolites and energy TAS 2543673
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0010467 gene expression TAS --
GO:0022904 respiratory electron transport chain TAS --
genes like me logo Genes that share ontologies with COX8A: view

Compounds for COX8A Gene

(2) HMDB Compounds for COX8A Gene

Compound Synonyms Cas Number PubMed IDs
  • Oxygen
  • Dihydrogen oxide

(2) Drugbank Compounds for COX8A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cholic Acid
81-25-4 target
genes like me logo Genes that share compounds with COX8A: view

Transcripts for COX8A Gene

mRNA/cDNA for COX8A Gene

(1333) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for COX8A Gene

Cytochrome c oxidase subunit VIIIA (ubiquitous):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COX8A Gene

No ASD Table

Relevant External Links for COX8A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COX8A Gene

mRNA expression in normal human tissues for COX8A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for COX8A Gene

SOURCE GeneReport for Unigene cluster for COX8A Gene Hs.743989

genes like me logo Genes that share expressions with COX8A: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COX8A Gene

Orthologs for COX8A Gene

This gene was present in the common ancestor of mammals.

Orthologs for COX8A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COX8A 35
  • 98.55 (n)
  • 98.55 (a)
COX8A 36
  • 99 (a)
(Bos Taurus)
Mammalia COX8A 36
  • 72 (a)
LOC783202 35
  • 80.68 (n)
  • 73.91 (a)
(Canis familiaris)
Mammalia -- 36
  • 65 (a)
COX8A 35
  • 80.19 (n)
  • 69.57 (a)
COX8A 36
  • 68 (a)
(Mus musculus)
Mammalia Cox8a 35
  • 78.74 (n)
  • 68.12 (a)
Cox8a 16
Cox8a 36
  • 67 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 44 (a)
(Rattus norvegicus)
Mammalia Cox8a 35
  • 76.81 (n)
  • 66.67 (a)
Species with no ortholog for COX8A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for COX8A Gene

Gene Tree for COX8A (if available)
Gene Tree for COX8A (if available)

Paralogs for COX8A Gene

Paralogs for COX8A Gene

Selected SIMAP similar genes for COX8A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with COX8A: view

Variants for COX8A Gene

Sequence variations from dbSNP and Humsavar for COX8A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs8360 -- 63,976,358(+) GACCA(C/G)CCCCA utr-variant-3-prime
rs1140595 -- 63,974,779(+) GAGGG(A/G)AAGCT synonymous-codon, reference
rs1187867 -- 63,973,737(+) caatc(C/T)cggct upstream-variant-2KB
rs1803315 -- 63,976,374(+) CCATC(C/T)TGGTC utr-variant-3-prime
rs7127354 -- 63,976,680(+) GTGCT(G/T)CTGTA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for COX8A Gene

Variant ID Type Subtype PubMed ID
dgv1155n71 CNV Loss 21882294
dgv1156n71 CNV Loss 21882294
nsv897639 CNV Loss 21882294
esv29993 CNV Loss 17803354

Relevant External Links for COX8A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX8A Gene

Disorders for COX8A Gene

(1) University of Copenhagen DISEASES for COX8A Gene

Relevant External Links for COX8A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with COX8A: view

No data available for UniProtKB/Swiss-Prot for COX8A Gene

Publications for COX8A Gene

  1. A gene specifying subunit VIII of human cytochrome c oxidase is localized to chromosome 11 and is expressed in both muscle and non- muscle tissues. (PMID: 2543673) Rizzuto R. … Schon E.A. (J. Biol. Chem. 1989) 2 3 4
  2. Human heart cytochrome c oxidase subunit VIII. Purification and determination of the complete amino acid sequence. (PMID: 2847943) van Kuilenburg A.B.P. … van Beeumen J.J. (FEBS Lett. 1988) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. A third isoform of cytochrome c oxidase subunit VIII is present in mammals. (PMID: 12909344) Huettemann M. … Grossman L.I. (Gene 2003) 3 23

Products for COX8A Gene

Sources for COX8A Gene

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