Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



COX8A Gene

protein-coding   GIFtS: 51
GCID: GC11P063742

Cytochrome C Oxidase Subunit VIIIA (Ubiquitous)

(Previous names: cytochrome c oxidase subunit VIII, cytochrome c oxidase...)
(Previous symbol: COX8)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cytochrome C Oxidase Subunit VIIIA (Ubiquitous)1 2     COX8L2 3
COX81 2 3 5     COX2
Cytochrome C Oxidase Subunit 8A (Ubiquitous)1 2     COX8-22
Cytochrome C Oxidase Subunit VIII1 2     VIII2
Cytochrome C Oxidase Polypeptide VIII-Liver/Heart2 3     VIII-L2
Cytochrome C Oxidase Subunit 8-22 3     Cytochrome C Oxidase Subunit 8A, Mitochondrial2

External Ids:    HGNC: 22941   Entrez Gene: 13512   Ensembl: ENSG000001763407   OMIM: 1238705   UniProtKB: P101763   

Export aliases for COX8A gene to outside databases

Previous GC identifers: GC11P063518 GC11P063498 GC11P060070


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for COX8A Gene:
The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of
electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical
gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which
perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in
number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be
involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits.
(provided by RefSeq, Jul 2008)

GeneCards Summary for COX8A Gene:
COX8A (cytochrome c oxidase subunit VIIIA (ubiquitous)) is a protein-coding gene. Diseases associated with COX8A include malignant glioma, and huntington's disease. GO annotations related to this gene include cytochrome-c oxidase activity. An important paralog of this gene is ENSG00000256100.

UniProtKB/Swiss-Prot: COX8A_HUMAN, P10176
Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal
oxidase in mitochondrial electron transport




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the COX8A gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B2   Olf-1   POU2F2   AREB6   POU2F1   POU2F1a   POU2F2B   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOX8A promoter sequence
   Search Chromatin IP Primers for COX8A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COX8A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12-q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q12-q13

COX8A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COX8A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P063742:  view genomic region     (about GC identifiers)

Start:
63,742,079 bp from pter      End:
63,744,015 bp from pter
Size:
1,937 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: COX8A_HUMAN, P10176 (See protein sequence)
Recommended Name: Cytochrome c oxidase subunit 8A, mitochondrial precursor  
Size: 69 amino acids; 7579 Da
Secondary accessions: P15955

Explore the universe of human proteins at neXtProt for COX8A: NX_P10176

Explore proteomics data for COX8A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See COX8A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004065.1  
    ENSEMBL proteins: 
     ENSP00000321260  
    Reactome Protein details: P10176

    COX8A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for COX8A
    GenScript Custom Purified and Recombinant Proteins Services for COX8A
    Novus Biologicals COX8A Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    COX8A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for COX8A
    OriGene Custom Antibody Services for COX8A
    Novus Biologicals COX8A Antibody
    Search for Antibodies for COX8A at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for COX8A
    Search LSBio for Antibodies for COX8A

    COX8A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for COX8A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for COX8A
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    comIV: Mitochondrial respiratory chain complex / Complex IV

    2 InterPro protein domains:
     IPR003205 Cyt_c_oxidase_su8
     IPR016070 Cyt_c_oxidase_su8/PSI_RC_su9

    Graphical View of Domain Structure for InterPro Entry P10176

    ProtoNet protein and cluster: P10176

    1 Blocks protein domain: IPB003205 Cytochrome oxidase c

    UniProtKB/Swiss-Prot: COX8A_HUMAN, P10176
    Similarity: Belongs to the cytochrome c oxidase VIII family


    COX8A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COX8A_HUMAN, P10176
    Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal
    oxidase in mitochondrial electron transport

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004129cytochrome-c oxidase activity IEA--
         
    COX8A for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COX8A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for COX8A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COX8A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COX8A

    miRNA
    Products:
        
    miRTarBase miRNAs that target COX8A:
    hsa-mir-484 (MIRT042264), hsa-mir-26b-5p (MIRT030182)

    Block miRNA regulation of human, mouse, rat COX8A using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate COX8A:
    hsa-miR-433 hsa-miR-298 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidCOX8A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for COX8A
    Predesigned siRNA for gene silencing in human, mouse, rat COX8A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for COX8A

    Clone
    Products:
         
    OriGene clones in human, mouse for COX8A (see all 6)
    OriGene ORF clones in mouse, rat for COX8A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COX8A (NM_004074)
    Sino Biological Human cDNA Clone for COX8A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COX8A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX8A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for COX8A
    Browse ESI BIO Cell Lines and PureStem Progenitors for COX8A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX8A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    COX8A_HUMAN, P10176: Mitochondrion inner membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol1
    extracellular1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005743mitochondrial inner membrane TAS--
    GO:0016021integral component of membrane IEA--

    COX8A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for COX8A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Oxidative phosphorylation0.64
    Respiratory electron transport0.81
    Parkinson's disease0.57
    Electron Transport Chain0.75
    Huntington's disease0.45
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Alzheimer's disease
    Alzheimer's disease0.44
    4Cardiac muscle contraction
    Cardiac muscle contraction
    5Arachidonate Epoxygenase / Epoxide Hydrolase
    Arachidonate Epoxygenase / Epoxide Hydrolase

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for COX8A
        AMPK Enzyme Complex Pathway

    2 BioSystems Pathways for COX8A
        Arachidonate Epoxygenase / Epoxide Hydrolase
    Electron Transport Chain


    1 Reactome Pathway for COX8A
        Respiratory electron transport


    Selected Kegg Pathways  (Kegg details for COX8A) (see all 7):
        Oxidative phosphorylation
    Metabolic pathways
    Cardiac muscle contraction
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease


    COX8A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including COX8A: 
              Mitochondrial Energy Metabolism in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for COX8A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for COX8A (ENSP000003212604) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COX4I1ENSP000002534524STRING: ENSP00000253452
    COX5AENSP000003177804STRING: ENSP00000317780
    COX5BENSP000002584244STRING: ENSP00000258424
    COX6B1ENSP000002465544STRING: ENSP00000246554
    COX6CENSP000002975644STRING: ENSP00000297564
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006091generation of precursor metabolites and energy TAS2543673
    GO:0022904respiratory electron transport chain TAS--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:1902600hydrogen ion transmembrane transport TAS2543673

    COX8A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COX8A

    2 HMDB Compounds for COX8A    About this table
    CompoundSynonyms CAS #PubMed Ids
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for COX8A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cholic Acid-- 81-25-4target--10592235
    N-Formylmethionine-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for COX8A gene: 
    NM_004074.2  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000314133(uc001nye.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat COX8A using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate COX8A:
    hsa-miR-433 hsa-miR-298 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidCOX8A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for COX8A
    Predesigned siRNA for gene silencing in human, mouse, rat COX8A
    Clone
    Products:
         
    OriGene clones in human, mouse for COX8A (see all 6)
    OriGene ORF clones in mouse, rat for COX8A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COX8A (NM_004074)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COX8A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX8A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for COX8A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COX8A
      QuantiTect SYBR Green Assays in human, mouse, rat COX8A
      QuantiFast Probe-based Assays in human, mouse, rat COX8A

    Selected AceView cDNA sequences (see all 1333):

    BE877230 BM782621 BE045671 BG326513 BU162844 BG327806 AI373150 BE855419 
    CR609784 CD244568 F28133 BQ896785 BQ056861 CR620541 CB112348 AA323553 
    F26706 BQ687690 CR604649 BM783268 F29137 BX394130 CR407687 CB109704 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    COX8A expression in normal human tissues (normalized intensities)      COX8A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGACCTCCT
    COX8A Expression
    About this image


    COX8A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    COX8A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COX8A Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Arrays including COX8A: 
              Mitochondrial Energy Metabolism in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for COX8A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COX8A
    QuantiTect SYBR Green Assays in human, mouse, rat COX8A
    QuantiFast Probe-based Assays in human, mouse, rat COX8A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX8A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for COX8A gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cox8a1 , 5 cytochrome c oxidase, subunit VIIIa5
    cytochrome c oxidase subunit VIIIa1
    78.74(n)1
    68.12(a)1
      19 (5.28 cM)5
    128681  NM_007750.21  NP_031776.11 
     72151585 


    ENSEMBL Gene Tree for COX8A (if available)
    TreeFam Gene Tree for COX8A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for COX8A gene
    ENSG000002561002  
    2 SIMAP similar genes for COX8A using alignment to 1 protein entry:     COX8A_HUMAN:
    COX8    COX8C

    COX8A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for COX8A (see all 107)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs680802151,2
    C--60073014(+) TGTGT-/GTGT  
      GTGTGT
    GTGTC
    1 -- ds50011Minor allele frequency- GTGTGTGTGT:0.00NA 2
    rs1926492381,2
    --63740185(+) TAGCCA/GGGCAT 1 -- us2k10--------
    rs778794571,2
    C--63740297(+) TCCAGAG/-CCTGG 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1828152541,2
    --63740312(+) AACAGC/TGCAAG 1 -- us2k10--------
    rs1874617551,2
    --63740379(+) GTAATC/TCCAGC 1 -- us2k10--------
    rs1486663091,2
    --63740578(+) GCAGGG/TTCGAA 1 -- us2k10--------
    rs1421524231,2
    C--63740590(+) GTGTGC/GAATAT 1 -- us2k10--------
    rs1140599061,2
    C,F--63740629(+) AGTGAC/TATCCG 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1468254671,2
    --63740634(+) CATCCA/GGGAAT 1 -- us2k10--------
    rs2015817501,2
    C--63740870(+) CGGAG-/GCCT  
            
    GCCTG
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for COX8A (63742079 - 63744015 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for COX8A:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1156n71CNV Loss21882294
    dgv1155n71CNV Loss21882294
    esv29993CNV Loss17803354
    nsv897639CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COX8A
    DNA2.0 Custom Variant and Variant Library Synthesis for COX8A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 123870    OMIM disorders: --

    11 diseases for COX8A:    About MalaCards
    malignant glioma    huntington's disease    fatty liver disease    hepatitis c virus
    hepatitis c    parkinson's disease    liver disease    alzheimer's disease
    hepatitis    hiv-1    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for COX8A:
    Malignant glioma

    COX8A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): COX8A
    Human Genome Epidemiology (HuGE) Navigator: COX8A (1 document)

    Export disorders for COX8A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for COX8A gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with COX8A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A gene specifying subunit VIII of human cytochrome c oxidase is localized to chromosome 11 and is expressed in both muscle and non- muscle tissues. (PubMed id 2543673)1, 2, 3 Rizzuto R.... Schon E.A. (J. Biol. Chem. 1989)
    2. Human heart cytochrome c oxidase subunit VIII. Purification and determination of the complete amino acid sequence. (PubMed id 2847943)1, 2, 3 van Kuilenburg A.B.P....van Beeumen J.J. (FEBS Lett. 1988)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. A third isoform of cytochrome c oxidase subunit VIII is present in mammals. (PubMed id 12909344)1, 9 Huettemann M.... Grossman L.I. (Gene 2003)
    6. HIV-1 Tat protein directly induces mitochondrial membrane permeabilization and inactivates cytochrome c oxidase. (PubMed id 22419111)1 Lecoeur H....Jacotot E. (amp 2012)
    7. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (Nucleic Acids Res. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1351 HGNC: 2294 AceView: COX8AandOTUB1 Ensembl:ENSG00000176340 euGenes: HUgn1351
    ECgene: COX8A Kegg: 1351 H-InvDB: COX8A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for COX8A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for COX8A gene:
    Search GeneIP for patents involving COX8A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for COX8A   OriGene RNAi products in human, mouse, rat for COX8A  
     OriGene qPCR primer pairs and template standards for COX8A   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for COX8A  
     Browse OriGene qSTAR qPCR primer pairs   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for COX8A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for COX8A   OriGene Custom Protein Services for COX8A  

     
     
     Block miRNA regulation of human, mouse, rat COX8A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing COX8A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COX8A Predesigned siRNA for gene silencing in human, mouse, rat COX8A
     QuantiFast Probe-based Assays in human, mouse, rat COX8A QuantiTect SYBR Green Assays in human, mouse, rat COX8A
     PCR Arrays including human, mouse, rat COX8A Search Chromatin IP Primers for COX8A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COX8A  Search GeneGlobe Interaction Network for COX8A
     Regulatory tfbs in COX8A promoter
     GenScript Custom Purified and Recombinant Proteins Services for COX8A GenScript cDNA clones with any tag delivered in your preferred vector for COX8A
     GenScript Custom Assay Services for COX8A GenScript Custom overexpressing Cell Line Services for COX8A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for COX8A
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for COX8A
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     COX8A antibodies
     COX8A proteins
     Search for Antibodies for COX8A at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for COX8A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for COX8A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX8A
     SwitchGear 3'UTR luciferase reporter plasmids for COX8A
     SwitchGear Promoter luciferase reporter plasmids for COX8A
     Search ThermoFisher Antibodies for COX8A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX8A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COX8A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for COX8A
     Search LSBio for Antibodies for COX8A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      COX8A gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4