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Aliases for COX7C Gene

Aliases for COX7C Gene

  • Cytochrome C Oxidase Subunit 7C 2 3 5
  • Cytochrome C Oxidase Polypeptide VIIc 4
  • Cytochrome C Oxidase Subunit VIIc 2

External Ids for COX7C Gene

Previous GeneCards Identifiers for COX7C Gene

  • GC05P084829
  • GC05P086101
  • GC05P085952
  • GC05P085997
  • GC05P085949
  • GC05P081115
  • GC05P085913

Summaries for COX7C Gene

Entrez Gene Summary for COX7C Gene

  • Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13. [provided by RefSeq, Jul 2008]

GeneCards Summary for COX7C Gene

COX7C (Cytochrome C Oxidase Subunit 7C) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include cytochrome-c oxidase activity.

UniProtKB/Swiss-Prot for COX7C Gene

  • This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Gene Wiki entry for COX7C Gene

Additional gene information for COX7C Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX7C Gene

Genomics for COX7C Gene

Regulatory Elements for COX7C Gene

Enhancers for COX7C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H086643 0.6 ENCODE dbSUPER 11.4 +26.7 26651 2.5 CTBP2 COX7C RASA1 RNU6-804P GC05M086664 PIR43647
GH05H086880 0.7 ENCODE 9.5 +263.1 263147 1.2 SMARCA5 CTCF ZNF654 STAT1 FOXA2 TEAD1 TRIM22 REST MIER2 RAD21 COX7C RPL10AP9 PIR36643 GC05P086855
GH05H087002 0.4 FANTOM5 9.5 +384.8 384769 0.3 FOXP2 COX7C LOC101929380 GC05P087050
GH05H086537 0.3 FANTOM5 10.5 -80.0 -80029 0.1 COX7C GC05M086541 PIR44300
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around COX7C on UCSC Golden Path with GeneCards custom track

Promoters for COX7C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000183552 496 1601 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 ZNF143

Genomic Locations for COX7C Gene

Genomic Locations for COX7C Gene
3,059 bases
Plus strand

Genomic View for COX7C Gene

Genes around COX7C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX7C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX7C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX7C Gene

Proteins for COX7C Gene

  • Protein details for COX7C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome c oxidase subunit 7C, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q6NR81

    Protein attributes for COX7C Gene

    63 amino acids
    Molecular mass:
    7246 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX7C Gene

Post-translational modifications for COX7C Gene

  • Ubiquitination at isoforms=25
  • Modification sites at PhosphoSitePlus

Other Protein References for COX7C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COX7C Gene

Domains & Families for COX7C Gene

Gene Families for COX7C Gene

Protein Domains for COX7C Gene

Suggested Antigen Peptide Sequences for COX7C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome c oxidase VIIc family.
  • Belongs to the cytochrome c oxidase VIIc family.
genes like me logo Genes that share domains with COX7C: view

Function for COX7C Gene

Molecular function for COX7C Gene

GENATLAS Biochemistry:
cytochrome c oxidase,subunit VIIc,component of the complex IV,terminal enzyme complex for electron transfer,oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Gene Ontology (GO) - Molecular Function for COX7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 contributes_to cytochrome-c oxidase activity IBA --
genes like me logo Genes that share ontologies with COX7C: view
genes like me logo Genes that share phenotypes with COX7C: view

miRNA for COX7C Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COX7C Gene

Localization for COX7C Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX7C Gene

Mitochondrion inner membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COX7C gene
Compartment Confidence
mitochondrion 5
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for COX7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA,IEA 20833797
GO:0005743 mitochondrial inner membrane TAS --
GO:0005751 mitochondrial respiratory chain complex IV IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with COX7C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for COX7C Gene

Pathways & Interactions for COX7C Gene

genes like me logo Genes that share pathways with COX7C: view

Gene Ontology (GO) - Biological Process for COX7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy TAS 2155413
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen TAS,IBA --
GO:1902600 hydrogen ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with COX7C: view

No data available for SIGNOR curated interactions for COX7C Gene

Drugs & Compounds for COX7C Gene

(4) Drugs for COX7C Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cholic acid Approved Pharma Full agonist, Agonist, Target 0
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
N-Formylmethionine Experimental Pharma Target 0
genes like me logo Genes that share compounds with COX7C: view

Transcripts for COX7C Gene

Unigene Clusters for COX7C Gene

Cytochrome c oxidase subunit VIIc:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for COX7C Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3
SP1: -
SP2: -

Relevant External Links for COX7C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COX7C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COX7C Gene

Protein differential expression in normal tissues from HIPED for COX7C Gene

This gene is overexpressed in Bone (20.3), Peripheral blood mononuclear cells (9.0), and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for COX7C Gene

Protein tissue co-expression partners for COX7C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of COX7C Gene:


SOURCE GeneReport for Unigene cluster for COX7C Gene:


Evidence on tissue expression from TISSUES for COX7C Gene

  • Heart(4.8)
  • Muscle(4.8)
  • Lung(4.7)
  • Nervous system(3.7)
  • Liver(3.1)
  • Intestine(2.8)
  • Kidney(2.8)
  • Spleen(2.6)
  • Adrenal gland(2.3)
  • Eye(2.3)
  • Pancreas(2.3)
  • Thyroid gland(2.3)
  • Lymph node(2.2)
  • Stomach(2.2)
  • Gall bladder(2.1)
  • Bone marrow(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with COX7C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for COX7C Gene

Orthologs for COX7C Gene

This gene was present in the common ancestor of animals.

Orthologs for COX7C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COX7C 33 34 34
  • 100 (n)
(Canis familiaris)
Mammalia LOC100686264 33
  • 88.17 (n)
COX7C 34
  • 82 (a)
(Bos Taurus)
Mammalia COX7C 34 34 34
  • 84 (a)
(Monodelphis domestica)
Mammalia COX7C 34
  • 81 (a)
(Mus musculus)
Mammalia Gm20091 34
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia COX7C 34
  • 34 (a)
(Gallus gallus)
Aves COX7C 34
  • 76 (a)
(Anolis carolinensis)
Reptilia COX7C 34
  • 76 (a)
(Danio rerio)
Actinopterygii cox7c 34
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CoVIIc 34
  • 45 (a)
Species where no ortholog for COX7C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COX7C Gene

Gene Tree for COX7C (if available)
Gene Tree for COX7C (if available)

Paralogs for COX7C Gene

genes like me logo Genes that share paralogs with COX7C: view

No data available for Paralogs for COX7C Gene

Variants for COX7C Gene

Sequence variations from dbSNP and Humsavar for COX7C Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000433990 -- 86,618,363(+) GCCAC(C/T)TGACG intron-variant
rs1000465045 -- 86,618,621(+) AGTAA(C/T)AATCT intron-variant, upstream-variant-2KB
rs1000630921 -- 86,617,281(+) TTCTT(C/T)TCTTA upstream-variant-2KB
rs1000795389 -- 86,617,435(+) TCATA(C/T)CAGAC upstream-variant-2KB
rs1001435985 -- 86,619,810(+) CATAA(C/T)TAGTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for COX7C Gene

Variant ID Type Subtype PubMed ID
nsv830375 CNV gain 17160897
nsv598839 CNV gain 21841781
esv3890667 CNV gain 25118596

Variation tolerance for COX7C Gene

Residual Variation Intolerance Score: 47.7% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COX7C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX7C Gene

Disorders for COX7C Gene

Relevant External Links for COX7C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for COX7C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX7C Gene

Publications for COX7C Gene

  1. Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping. (PMID: 10072584) Hofmann S … Meitinger T (Cytogenetics and cell genetics 1998) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart. (PMID: 1309697) Van Kuilenburg AB … Muijsers AO (European journal of biochemistry 1992) 3 4 60
  4. Sequence of a cDNA specifying subunit VIIc of human cytochrome c oxidase. (PMID: 2155413) Koga Y … Schon EA (Nucleic acids research 1990) 3 4 60
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 60

Products for COX7C Gene

Sources for COX7C Gene

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