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Aliases for COX7C Gene

Aliases for COX7C Gene

  • Cytochrome C Oxidase Subunit 7C 2 3
  • Cytochrome C Oxidase Subunit VIIc 2 5
  • Cytochrome C Oxidase Polypeptide VIIc 4

External Ids for COX7C Gene

Previous GeneCards Identifiers for COX7C Gene

  • GC05P084829
  • GC05P086101
  • GC05P085952
  • GC05P085997
  • GC05P085949
  • GC05P081115
  • GC05P085913

Summaries for COX7C Gene

Entrez Gene Summary for COX7C Gene

  • Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13. [provided by RefSeq, Jul 2008]

GeneCards Summary for COX7C Gene

COX7C (Cytochrome C Oxidase Subunit 7C) is a Protein Coding gene. Among its related pathways are Gene Expression and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include cytochrome-c oxidase activity.

UniProtKB/Swiss-Prot for COX7C Gene

  • This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Gene Wiki entry for COX7C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX7C Gene

Genomics for COX7C Gene

Regulatory Elements for COX7C Gene

Promoters for COX7C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COX7C on UCSC Golden Path with GeneCards custom track

Genomic Location for COX7C Gene

86,617,904 bp from pter
86,620,962 bp from pter
3,059 bases
Plus strand

Genomic View for COX7C Gene

Genes around COX7C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX7C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX7C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX7C Gene

Proteins for COX7C Gene

  • Protein details for COX7C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome c oxidase subunit 7C, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q6NR81

    Protein attributes for COX7C Gene

    63 amino acids
    Molecular mass:
    7246 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX7C Gene

Proteomics data for COX7C Gene at MOPED

Post-translational modifications for COX7C Gene

  • Ubiquitination at Lys 25
  • Modification sites at PhosphoSitePlus

Other Protein References for COX7C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COX7C Gene

Domains & Families for COX7C Gene

Protein Domains for COX7C Gene

Suggested Antigen Peptide Sequences for COX7C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome c oxidase VIIc family.
  • Belongs to the cytochrome c oxidase VIIc family.
genes like me logo Genes that share domains with COX7C: view

Function for COX7C Gene

Molecular function for COX7C Gene

GENATLAS Biochemistry:
cytochrome c oxidase,subunit VIIc,component of the complex IV,terminal enzyme complex for electron transfer,oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
genes like me logo Genes that share phenotypes with COX7C: view

Animal Model Products

miRNA for COX7C Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COX7C Gene

Localization for COX7C Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX7C Gene

Mitochondrion inner membrane.

Subcellular locations from

Jensen Localization Image for COX7C Gene COMPARTMENTS Subcellular localization image for COX7C gene
Compartment Confidence
mitochondrion 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for COX7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 20833797
genes like me logo Genes that share ontologies with COX7C: view

Pathways & Interactions for COX7C Gene

genes like me logo Genes that share pathways with COX7C: view

Gene Ontology (GO) - Biological Process for COX7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0022904 respiratory electron transport chain TAS --
GO:1902600 hydrogen ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with COX7C: view

No data available for SIGNOR curated interactions for COX7C Gene

Drugs & Compounds for COX7C Gene

(2) Drugs for COX7C Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cholic acid Approved Pharma Full agonist, Agonist, Target 0
N-Formylmethionine Experimental Pharma Target 0

(2) Additional Compounds for COX7C Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with COX7C: view

Transcripts for COX7C Gene

Unigene Clusters for COX7C Gene

Cytochrome c oxidase subunit VIIc:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COX7C Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3
SP1: -
SP2: -

Relevant External Links for COX7C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COX7C Gene

mRNA expression in normal human tissues for COX7C Gene

Protein differential expression in normal tissues from HIPED for COX7C Gene

This gene is overexpressed in Bone (20.3), Peripheral blood mononuclear cells (9.0), and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COX7C Gene

SOURCE GeneReport for Unigene cluster for COX7C Gene Hs.430075

genes like me logo Genes that share expression patterns with COX7C: view

Protein tissue co-expression partners for COX7C Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COX7C Gene

Orthologs for COX7C Gene

This gene was present in the common ancestor of animals.

Orthologs for COX7C Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC100686264 35
  • 88.17 (n)
  • 87.1 (a)
COX7C 36
  • 82 (a)
(Pan troglodytes)
Mammalia COX7C 35
  • 100 (n)
  • 100 (a)
COX7C 36
  • 100 (a)
COX7C 36
  • 100 (a)
(Bos Taurus)
Mammalia COX7C 36
  • 84 (a)
COX7C 36
  • 84 (a)
COX7C 36
  • 84 (a)
(Monodelphis domestica)
Mammalia COX7C 36
  • 81 (a)
(Mus musculus)
Mammalia Gm20091 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia COX7C 36
  • 34 (a)
(Gallus gallus)
Aves COX7C 36
  • 76 (a)
(Anolis carolinensis)
Reptilia COX7C 36
  • 76 (a)
(Danio rerio)
Actinopterygii cox7c 36
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CoVIIc 36
  • 45 (a)
Species with no ortholog for COX7C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COX7C Gene

Gene Tree for COX7C (if available)
Gene Tree for COX7C (if available)

Paralogs for COX7C Gene

genes like me logo Genes that share paralogs with COX7C: view

No data available for Paralogs for COX7C Gene

Variants for COX7C Gene

Sequence variations from dbSNP and Humsavar for COX7C Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10462454 -- 86,616,797(+) ATGCC(C/G)TTTTC upstream-variant-2KB
rs13161296 -- 86,617,233(+) ttgga(C/T)aatgt upstream-variant-2KB
rs34322192 -- 86,615,974(+) TAAAC(-/T)TTTTT upstream-variant-2KB
rs13176061 -- 86,616,295(+) TTTTG(G/T)ATTTA upstream-variant-2KB
rs111395116 -- 86,616,238(+) CCAAA(A/G)TGCTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for COX7C Gene

Variant ID Type Subtype PubMed ID
nsv882334 CNV Gain 21882294
nsv882351 CNV Gain 21882294
nsv830375 CNV Gain 17160897

Variation tolerance for COX7C Gene

Residual Variation Intolerance Score: 47.7% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for COX7C Gene

Disorders for COX7C Gene

Relevant External Links for COX7C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for COX7C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX7C Gene

Publications for COX7C Gene

  1. Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping. (PMID: 10072584) Hofmann S. … Meitinger T. (Cytogenet. Cell Genet. 1998) 2 3 4 67
  2. The Protein Data Bank. (PMID: 10592235) Berman H.M. … Bourne P.E. (Nucleic Acids Res. 2000) 25 26
  3. Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus. (PMID: 25505242) Fernandez J. … Arhel N.J. (J. Biol. Chem. 2015) 3
  4. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. (PMID: 23720494) Evans D.M. … Whitfield J.B. (Hum. Mol. Genet. 2013) 3
  5. HIV-1 Tat protein directly induces mitochondrial membrane permeabilization and inactivates cytochrome c oxidase. (PMID: 22419111) Lecoeur H. … Jacotot E. (Cell Death Dis 2012) 3

Products for COX7C Gene

Sources for COX7C Gene