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COX7C Gene

protein-coding   GIFtS: 59
GCID: GC05P085913

Cytochrome C Oxidase Subunit VIIc

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome C Oxidase Subunit VIIc1 2
Cytochrome C Oxidase Polypeptide VIIc2 3
Cytochrome C Oxidase Subunit 7C, Mitochondrial2
Cytochrome-C Oxidase Chain VIIc2

External Ids:    HGNC: 22921   Entrez Gene: 13502   Ensembl: ENSG000001271847   OMIM: 6037745   UniProtKB: P159543   

Export aliases for COX7C gene to outside databases

Previous GC identifers: GC05P084829 GC05P086101 GC05P085952 GC05P085997 GC05P085949 GC05P081115


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COX7C Gene:
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron
transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic
subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The
mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in
the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85%
amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A
pseudogene COX7CP1 has been found on chromosome 13. (provided by RefSeq, Jul 2008)

GeneCards Summary for COX7C Gene:
COX7C (cytochrome c oxidase subunit VIIc) is a protein-coding gene. GO annotations related to this gene include cytochrome-c oxidase activity.

UniProtKB/Swiss-Prot: COX7C_HUMAN, P15954
Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal
oxidase in mitochondrial electron transport

Gene Wiki entry for COX7C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the COX7C gene promoter:
         Nkx3-1   TBP   STAT1   Pbx1a   STAT5A   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   HOXA5   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOX7C promoter sequence
   Search Chromatin IP Primers for COX7C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COX7C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q14   Ensembl cytogenetic band:  5q14.3   HGNC cytogenetic band: 5q14

COX7C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COX7C gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P085913:  view genomic region     (about GC identifiers)

Start:
85,913,721 bp from pter      End:
85,916,779 bp from pter
Size:
3,059 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: COX7C_HUMAN, P15954 (See protein sequence)
Recommended Name: Cytochrome c oxidase subunit 7C, mitochondrial precursor  
Size: 63 amino acids; 7246 Da
Secondary accessions: Q6NR81

Explore the universe of human proteins at neXtProt for COX7C: NX_P15954

Explore proteomics data for COX7C at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys25
  • Modification sites at PhosphoSitePlus

  • See COX7C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001858.1  
    ENSEMBL proteins: 
     ENSP00000247655   ENSP00000425759   ENSP00000422012  
    Reactome Protein details: P15954

    COX7C Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for COX7C (2 products) 

     
    antibodies-online peptides for COX7C

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    antibodies-online kits for COX7C (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    comIV: Mitochondrial respiratory chain complex / Complex IV

    1 InterPro protein domain:
     IPR004202 COX7C/Cox8

    Graphical View of Domain Structure for InterPro Entry P15954

    ProtoNet protein and cluster: P15954

    1 Blocks protein domain: IPB004202 Cytochrome c oxidase subunit VIIc

    UniProtKB/Swiss-Prot: COX7C_HUMAN, P15954
    Similarity: Belongs to the cytochrome c oxidase VIIc family


    Find genes that share domains with COX7C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COX7C_HUMAN, P15954
    Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal
    oxidase in mitochondrial electron transport

         Genatlas biochemistry entry for COX7C:
    cytochrome c oxidase,subunit VIIc,component of the complex IV,terminal enzyme complex for electron
    transfer,oxidative phosphorylation (OXPHOS),inner mitochondrial membrane

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004129cytochrome-c oxidase activity IEA--
         
    Find genes that share ontologies with COX7C           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Cox7c (no phenotypes)

    Find genes that share phenotypes with COX7C           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for COX7C

    miRNA
    Products:
        
    miRTarBase miRNAs that target COX7C:
    hsa-mir-193b-3p (MIRT041272), hsa-mir-324-3p (MIRT042980), hsa-mir-125b-5p (MIRT045951), hsa-mir-331-3p (MIRT043481)

    Block miRNA regulation of human, mouse, rat COX7C using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate COX7C:
    hsa-miR-640
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX7C

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COX7C_HUMAN, P15954: Mitochondrion inner membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion4
    cytosol1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with COX7C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for COX7C About    
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Oxidative phosphorylation0.64
    Respiratory electron transport0.81
    Parkinson's disease0.57
    Electron Transport Chain0.75
    Huntington's disease0.45
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Alzheimer's disease
    Alzheimer's disease0.44
    4Cardiac muscle contraction
    Cardiac muscle contraction
    5AMPK Enzyme Complex Pathway
    AMPK Enzyme Complex Pathway


    Find genes that share SuperPaths with COX7C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for COX7C
        AMPK Enzyme Complex Pathway

    1 BioSystems Pathway for COX7C
        Electron Transport Chain

    1 Reactome Pathway for COX7C
        Respiratory electron transport


    Selected Kegg Pathways  (Kegg details for COX7C) (see all 7):
        Oxidative phosphorylation
    Metabolic pathways
    Cardiac muscle contraction
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for COX7C
    Interactions:

        Search GeneGlobe Interaction Network for COX7C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COX7C (P159543 ENSP000002476554) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MT-CO2P004033, ENSP000003548764I2D: score=1 STRING: ENSP00000354876
    COX4I1ENSP000002534524STRING: ENSP00000253452
    COX7A2LENSP000002343014STRING: ENSP00000234301
    COX8AENSP000003212604STRING: ENSP00000321260
    UQCRFS1ENSP000003063974STRING: ENSP00000306397
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006091generation of precursor metabolites and energy TAS2155413
    GO:0022904respiratory electron transport chain TAS--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with COX7C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COX7C

    2 HMDB Compounds for COX7C    About this table
    CompoundSynonyms CAS #PubMed Ids
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for COX7C    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cholic Acid-- 81-25-4target--10592235
    N-Formylmethionine-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for COX7C gene: 
    NM_001867.2  

    Unigene Cluster for COX7C:

    Cytochrome c oxidase subunit VIIc
    Hs.430075  [show with all ESTs]
    Unigene Representative Sequence: BM544659
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000247655(uc003kir.3) ENST00000511472 ENST00000505430 ENST00000509578
    ENST00000515763 ENST00000513124 ENST00000510447
    miRNA
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    hsa-miR-640
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat COX7C
      QuantiFast Probe-based Assays in human, mouse, rat COX7C

    Additional mRNA sequence: 

    AK026505.1 AK309192.1 BC001005.2 BC007498.2 BT007098.1 X16560.1 

    Selected DOTS entries (see all 32):

    DT.120304  DT.91911310  DT.100890805  DT.92026260  DT.101987320  DT.120859006  DT.100890809  DT.101987318 
    DT.120764317  DT.92008652  DT.100039390  DT.100039389  DT.121434583  DT.100801575  DT.120305  DT.120764295 
    DT.120859019  DT.100890788  DT.100890789  DT.95363345  DT.100890787  DT.100890794  DT.100890801  DT.120858991 

    Selected AceView cDNA sequences (see all 942):

    BM090582 AI948437 AA732005 BM693307 CB151411 BM786649 BM818189 BQ058535 
    BI836377 AI203961 F21632 AW189111 CB128434 AA514647 AI814267 AI879841 
    BM781811 N64343 T59441 AA627855 BM764579 W32092 BE873665 AA214498 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for COX7C    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3
    SP1:                          -         
    SP2:              -                     


    ECgene alternative splicing isoforms for COX7C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COX7C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    COX7C Expression
    About this image


    COX7C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Thymus (Hematopoietic System)
             Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Neural Tube (Nervous System)
             Telencephalon
    COX7C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COX7C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.430075
        Custom PCR Arrays for COX7C
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX7C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for COX7C gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cox7c5 cytochrome c oxidase, subunit VIIc   --   13 (45.10 cM) 86044816 
    chicken
    (Gallus gallus)
    Aves COX7C6
    cytochrome c oxidase subunit VIIc
    76(a)
    1 ↔ 1
    Z(61059202-61062815)
    lizard
    (Anolis carolinensis)
    Reptilia COX7C6
    cytochrome c oxidase subunit VIIc
    76(a)
    1 ↔ 1
    2(20639198-20642735)
    African clawed frog
    (Xenopus laevis)
    Amphibia AJ009281.12   -- 70.62(n)    AJ009281.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cox7c6
    cytochrome c oxidase, subunit VIIc
    75(a)
    1 ↔ 1
    5(48696789-48698411) ENSDARG00000053382
    fruit fly
    (Drosophila melanogaster)
    Insecta CoVIIc6
    Cytochrome c oxidase subunit VIIc
    45(a)
    1 ↔ 1
    2R(5936985-5938379)


    ENSEMBL Gene Tree for COX7C (if available)
    TreeFam Gene Tree for COX7C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for COX7C gene

    Find genes that share paralogs with COX7C           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for COX7C
    PGOHUM00000238644 PGOHUM00000238837 PGOHUM00000242907 PGOHUM00000248707 PGOHUM00000244390


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COX7C (see all 70)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs343221921,2
    C--85911791(+) TAAAC-/TTTTTT 1 -- us2k10--------
    rs1885427591,2
    --85911824(+) GTCTCA/GCTCTG 1 -- us2k10--------
    rs1455875061,2
    C--85911884(+) GCCTCC/TCGGGT 1 -- us2k10--------
    rs1906896781,2
    --85911891(+) GGGTTC/GACACC 1 -- us2k10--------
    rs1833096951,2
    --85911906(+) TCCTGC/TCCCCG 1 -- us2k10--------
    rs1879929221,2
    --85912083(+) CACCGC/GGCCCG 1 -- us2k10--------
    rs1118876751,2
    C--85912119(+) TTTAAG/CTTACC 1 -- us2k11Minor allele frequency- C:0.50WA 2
    rs1914023111,2
    --85912163(+) CCATAC/TTCTGG 1 -- us2k10--------
    rs1836493431,2
    C--85912172(+) GGAATA/CTCTGC 1 -- us2k10--------
    rs1484585571,2
    --85912187(+) CAGGTA/CCCTAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for COX7C (85913721 - 85916779 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for COX7C:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830375CNV Gain17160897
    nsv882351CNV Gain21882294
    nsv882334CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COX7C
    DNA2.0 Custom Variant and Variant Library Synthesis for COX7C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603774    OMIM disorders: --


    Find genes that share disorders with COX7C           About GenesLikeMe

    Genetic Association Database (GAD): COX7C
    Human Genome Epidemiology (HuGE) Navigator: COX7C (1 document)

    Export disorders for COX7C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COX7C gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with COX7C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping. (PubMed id 10072584)1, 2, 3 Hofmann S.... Meitinger T. (Cytogenet. Cell Genet. 1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart. (PubMed id 1309697)1, 2 van Kuilenburg A.B.P....Muijsers A.O. (Eur. J. Biochem. 1992)
    4. Sequence of a cDNA specifying subunit VIIc of human cytochrome c oxidase. (PubMed id 2155413)1, 2 Koga Y.... Schon E.A. (Nucleic Acids Res. 1990)
    5. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. (PubMed id 23720494)1 Evans D.M....Whitfield J.B. (Hum. Mol. Genet. 2013)
    6. HIV-1 Tat protein directly induces mitochondrial membrane permeabilization and inactivates cytochrome c oxidase. (PubMed id 22419111)1 Lecoeur H....Jacotot E. (amp 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells. (PubMed id 17516841)1 Sirchia R. and Luparello C. (Biol. Chem. 2007)
    10. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1350 HGNC: 2292 AceView: COX7C Ensembl:ENSG00000127184 euGenes: HUgn1350
    ECgene: COX7C Kegg: 1350 H-InvDB: COX7C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for COX7C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for COX7C gene:
    Search GeneIP for patents involving COX7C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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