Free for academic non-profit institutions. Other users need a Commercial license

Aliases for COX7C Gene

Aliases for COX7C Gene

  • Cytochrome C Oxidase Subunit VIIc 2 3
  • Cytochrome C Oxidase Polypeptide VIIc 4

External Ids for COX7C Gene

Summaries for COX7C Gene

Entrez Gene Summary for COX7C Gene

  • Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13. [provided by RefSeq, Jul 2008]

GeneCards Summary for COX7C Gene

COX7C (Cytochrome C Oxidase Subunit VIIc) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include cytochrome-c oxidase activity.

UniProtKB/Swiss-Prot for COX7C Gene

  • This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Gene Wiki entry for COX7C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX7C Gene

Genomics for COX7C Gene

Genomic Location for COX7C Gene

Start:
86,617,904 bp from pter
End:
86,620,962 bp from pter
Size:
3,059 bases
Orientation:
Plus strand

Genomic View for COX7C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COX7C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX7C Gene

Regulatory Elements for COX7C Gene

Proteins for COX7C Gene

  • Protein details for COX7C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15954-COX7C_HUMAN
    Recommended name:
    Cytochrome c oxidase subunit 7C, mitochondrial
    Protein Accession:
    P15954
    Secondary Accessions:
    • Q6NR81

    Protein attributes for COX7C Gene

    Size:
    63 amino acids
    Molecular mass:
    7246 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX7C Gene

Proteomics data for COX7C Gene at MOPED

Post-translational modifications for COX7C Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys25

Other Protein References for COX7C Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for COX7C Gene

Domains for COX7C Gene

Gene Families for COX7C Gene

HGNC:
  • comIV :Mitochondrial respiratory chain complex / Complex IV

Protein Domains for COX7C Gene

UniProtKB/Swiss-Prot:

COX7C_HUMAN
Family:
  • Belongs to the cytochrome c oxidase VIIc family.:
    • P15954
genes like me logo Genes that share domains with COX7C: view

Function for COX7C Gene

Molecular function for COX7C Gene

GENATLAS Biochemistry: cytochrome c oxidase,subunit VIIc,component of the complex IV,terminal enzyme complex for electron transfer,oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Gene Ontology (GO) - Molecular Function for COX7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 cytochrome-c oxidase activity IEA --
genes like me logo Genes that share ontologies with COX7C: view

miRNA for COX7C Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for COX7C Gene

Localization for COX7C Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX7C Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COX7C Gene COMPARTMENTS Subcellular localization image for COX7C gene
Compartment Confidence
mitochondrion 4
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for COX7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 20833797
GO:0005743 mitochondrial inner membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with COX7C: view

Pathways for COX7C Gene

genes like me logo Genes that share pathways with COX7C: view

Gene Ontology (GO) - Biological Process for COX7C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy TAS 2155413
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0010467 gene expression TAS --
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
genes like me logo Genes that share ontologies with COX7C: view

Compounds for COX7C Gene

(2) HMDB Compounds for COX7C Gene

Compound Synonyms Cas Number PubMed IDs
Oxygen
  • Oxygen
7782-44-7
Water
  • Dihydrogen oxide
7732-18-5

(2) Drugbank Compounds for COX7C Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cholic Acid
81-25-4 target
N-Formylmethionine
target
genes like me logo Genes that share compounds with COX7C: view

Transcripts for COX7C Gene

mRNA/cDNA for COX7C Gene

Unigene Clusters for COX7C Gene

Cytochrome c oxidase subunit VIIc:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COX7C Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3
SP1: -
SP2: -

Relevant External Links for COX7C Gene

GeneLoc Exon Structure for
COX7C
ECgene alternative splicing isoforms for
COX7C

Expression for COX7C Gene

mRNA expression in normal human tissues for COX7C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COX7C Gene

SOURCE GeneReport for Unigene cluster for COX7C Gene Hs.430075

genes like me logo Genes that share expressions with COX7C: view

Orthologs for COX7C Gene

This gene was present in the common ancestor of animals.

Orthologs for COX7C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COX7C 36
  • 100 (n)
  • 100 (a)
COX7C 37
  • 100 (a)
OneToMany
COX7C 37
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia COX7C 37
  • 84 (a)
OneToMany
COX7C 37
  • 84 (a)
OneToMany
COX7C 37
  • 84 (a)
OneToMany
dog
(Canis familiaris)
Mammalia COX7C 37
  • 82 (a)
OneToOne
LOC100686264 36
  • 88.17 (n)
  • 87.1 (a)
mouse
(Mus musculus)
Mammalia Cox7c 16
Gm20091 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COX7C 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COX7C 37
  • 34 (a)
OneToOne
chicken
(Gallus gallus)
Aves COX7C 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COX7C 37
  • 76 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cox7c 37
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CoVIIc 37
  • 45 (a)
OneToOne
Species with no ortholog for COX7C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COX7C Gene

ENSEMBL:
Gene Tree for COX7C (if available)
TreeFam:
Gene Tree for COX7C (if available)

Paralogs for COX7C Gene

genes like me logo Genes that share paralogs with COX7C: view

No data available for Paralogs for COX7C Gene

Variants for COX7C Gene

Sequence variations from dbSNP and Humsavar for COX7C Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs10059868 -- 86,616,740(+) TCTCT(C/T)CCAAA upstream-variant-2KB
rs10462454 -- 86,616,797(+) ATGCC(C/G)TTTTC upstream-variant-2KB
rs13161296 -- 86,617,233(+) ttgga(C/T)aatgt upstream-variant-2KB
rs13176061 -- 86,616,295(+) TTTTG(G/T)ATTTA upstream-variant-2KB
rs16902281 -- 86,617,929(+) CCCCA(C/T)TTCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for COX7C Gene

Variant ID Type Subtype PubMed ID
nsv882334 CNV Gain 21882294
nsv882351 CNV Gain 21882294
nsv830375 CNV Gain 17160897

Relevant External Links for COX7C Gene

HapMap Linkage Disequilibrium report
COX7C

Disorders for COX7C Gene

Relevant External Links for COX7C

Genetic Association Database (GAD)
COX7C
Human Genome Epidemiology (HuGE) Navigator
COX7C
genes like me logo Genes that share disorders with COX7C: view

No data available for UniProtKB/Swiss-Prot for COX7C Gene

Publications for COX7C Gene

  1. Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping. (PMID: 10072584) Hofmann S. … Meitinger T. (Cytogenet. Cell Genet. 1998) 2 3 4
  2. Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart. (PMID: 1309697) van Kuilenburg A.B.P. … Muijsers A.O. (Eur. J. Biochem. 1992) 3 4
  3. Sequence of a cDNA specifying subunit VIIc of human cytochrome c oxidase. (PMID: 2155413) Koga Y. … Schon E.A. (Nucleic Acids Res. 1990) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells. (PMID: 17516841) Sirchia R. … Luparello C. (Biol. Chem. 2007) 3

Products for COX7C Gene

Sources for COX7C Gene

Back to Top

Content