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Aliases for COX7B2 Gene

Aliases for COX7B2 Gene

  • Cytochrome C Oxidase Subunit VIIb2 2 3
  • Cytochrome C Oxidase Polypeptide VIIb2 4

External Ids for COX7B2 Gene

Previous GeneCards Identifiers for COX7B2 Gene

  • GC04M046807
  • GC04M047046
  • GC04M046586
  • GC04M046577
  • GC04M046431
  • GC04M046055

Summaries for COX7B2 Gene

GeneCards Summary for COX7B2 Gene

COX7B2 (Cytochrome C Oxidase Subunit VIIb2) is a Protein Coding gene. Among its related pathways are Metabolism and AMPK Enzyme Complex Pathway. GO annotations related to this gene include cytochrome-c oxidase activity. An important paralog of this gene is COX7B.

UniProtKB/Swiss-Prot for COX7B2 Gene

  • This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX7B2 Gene

Genomics for COX7B2 Gene

Regulatory Elements for COX7B2 Gene

Genomic Location for COX7B2 Gene

Start:
46,734,827 bp from pter
End:
46,909,235 bp from pter
Size:
174,409 bases
Orientation:
Minus strand

Genomic View for COX7B2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COX7B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX7B2 Gene

Proteins for COX7B2 Gene

  • Protein details for COX7B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF08-CX7B2_HUMAN
    Recommended name:
    Cytochrome c oxidase subunit 7B2, mitochondrial
    Protein Accession:
    Q8TF08
    Secondary Accessions:
    • Q32Q40

    Protein attributes for COX7B2 Gene

    Size:
    81 amino acids
    Molecular mass:
    9077 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH35923.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI07856.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL75946.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for COX7B2 Gene

Proteomics data for COX7B2 Gene at MOPED

Post-translational modifications for COX7B2 Gene

No Post-translational modifications

Other Protein References for COX7B2 Gene

Antibody Products

No data available for DME Specific Peptides for COX7B2 Gene

Domains for COX7B2 Gene

Gene Families for COX7B2 Gene

HGNC:
  • comIV :Mitochondrial respiratory chain complex / Complex IV

Protein Domains for COX7B2 Gene

Suggested Antigen Peptide Sequences for COX7B2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TF08

UniProtKB/Swiss-Prot:

CX7B2_HUMAN :
  • Q8TF08
Family:
  • Belongs to the cytochrome c oxidase VIIb family.
genes like me logo Genes that share domains with COX7B2: view

Function for COX7B2 Gene

Molecular function for COX7B2 Gene

UniProtKB/Swiss-Prot Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Gene Ontology (GO) - Molecular Function for COX7B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 cytochrome-c oxidase activity IEA --
genes like me logo Genes that share ontologies with COX7B2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COX7B2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for COX7B2 Gene

Localization for COX7B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX7B2 Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COX7B2 Gene COMPARTMENTS Subcellular localization image for COX7B2 gene
Compartment Confidence
mitochondrion 3

Gene Ontology (GO) - Cellular Components for COX7B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005746 mitochondrial respiratory chain IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with COX7B2: view

Pathways for COX7B2 Gene

genes like me logo Genes that share pathways with COX7B2: view

Pathways by source for COX7B2 Gene

Interacting Proteins for COX7B2 Gene

Gene Ontology (GO) - Biological Process for COX7B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1902600 hydrogen ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with COX7B2: view

Compounds for COX7B2 Gene

(2) HMDB Compounds for COX7B2 Gene

Compound Synonyms Cas Number PubMed IDs
Oxygen
  • Oxygen
7782-44-7
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with COX7B2: view

Transcripts for COX7B2 Gene

Unigene Clusters for COX7B2 Gene

Cytochrome c oxidase subunit VIIb2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COX7B2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COX7B2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for COX7B2 Gene

GeneLoc Exon Structure for
COX7B2
ECgene alternative splicing isoforms for
COX7B2

Expression for COX7B2 Gene

mRNA expression in normal human tissues for COX7B2 Gene

mRNA differential expression in normal tissues according to GTEx for COX7B2 Gene

This gene is overexpressed in Testis (52.4).

SOURCE GeneReport for Unigene cluster for COX7B2 Gene Hs.479656

genes like me logo Genes that share expressions with COX7B2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for COX7B2 Gene

Orthologs for COX7B2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COX7B2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia COX7B2 35
  • 82.92 (n)
  • 73.75 (a)
COX7B2 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC100615314 35
  • 98.77 (n)
  • 98.77 (a)
COX7B2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cox7b2 16
Cox7b2 36
  • 57 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COX7B 36
  • 71 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 35 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 48 (a)
OneToMany
Species with no ortholog for COX7B2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for COX7B2 Gene

ENSEMBL:
Gene Tree for COX7B2 (if available)
TreeFam:
Gene Tree for COX7B2 (if available)

Paralogs for COX7B2 Gene

Paralogs for COX7B2 Gene

Selected SIMAP similar genes for COX7B2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with COX7B2: view

Variants for COX7B2 Gene

Sequence variations from dbSNP and Humsavar for COX7B2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs925479 -- 46,837,351(-) TATAT(C/T)ACTTC intron-variant
rs1002190 -- 46,861,777(+) cagct(A/G)tgcca intron-variant
rs1123700 -- 46,864,083(-) ccctt(G/T)ttgga intron-variant
rs1124442 -- 46,864,234(+) CAGGG(A/G)ATCAC intron-variant
rs1355578 -- 46,897,604(+) CCCCT(C/T)GGTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COX7B2 Gene

Variant ID Type Subtype PubMed ID
dgv5541n71 CNV Loss 21882294
esv2727525 CNV Deletion 23290073
esv2727526 CNV Deletion 23290073
nsv292736 CNV Insertion 16902084
nsv291043 CNV Insertion 16902084
esv2657595 CNV Deletion 23128226
esv273230 CNV Insertion 20981092
esv2450256 CNV Deletion 19546169
esv2410412 CNV Deletion 18987734
esv2666146 CNV Deletion 23128226
nsv879001 CNV Loss 21882294
esv2672767 CNV Deletion 23128226

Relevant External Links for COX7B2 Gene

HapMap Linkage Disequilibrium report
COX7B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX7B2 Gene

Disorders for COX7B2 Gene

Relevant External Links for COX7B2

Genetic Association Database (GAD)
COX7B2
Human Genome Epidemiology (HuGE) Navigator
COX7B2

No disorders were found for COX7B2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for COX7B2 Gene

Publications for COX7B2 Gene

  1. A rare polymorphism of the COX7B2 gene in a Cantonese family with nasopharyngeal carcinoma. (PMID: 15623157) Liang H. … Zeng Y. (Sci. China, Ser. C, Life Sci. 2004) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 48
  4. HIV-1 Tat protein directly induces mitochondrial membrane permeabilization and inactivates cytochrome c oxidase. (PMID: 22419111) Lecoeur H. … Jacotot E. (Cell Death Dis 2012) 3
  5. Genome-wide meta-analysis identifies new susceptibility loci for migraine. (PMID: 23793025) Anttila V. … . (Nat. Genet. 2013) 3

Products for COX7B2 Gene

Sources for COX7B2 Gene

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