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Aliases for COX7B2 Gene

Aliases for COX7B2 Gene

  • Cytochrome C Oxidase Subunit 7B2 2 3
  • Cytochrome C Oxidase Subunit VIIb2 2 5
  • Cytochrome C Oxidase Polypeptide VIIb2 4

External Ids for COX7B2 Gene

Previous GeneCards Identifiers for COX7B2 Gene

  • GC04M046807
  • GC04M047046
  • GC04M046586
  • GC04M046577
  • GC04M046431
  • GC04M046055

Summaries for COX7B2 Gene

GeneCards Summary for COX7B2 Gene

COX7B2 (Cytochrome C Oxidase Subunit 7B2) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include cytochrome-c oxidase activity. An important paralog of this gene is COX7B.

UniProtKB/Swiss-Prot for COX7B2 Gene

  • This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX7B2 Gene

Genomics for COX7B2 Gene

Regulatory Elements for COX7B2 Gene

Enhancers for COX7B2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around COX7B2 on UCSC Golden Path with GeneCards custom track

Genomic Location for COX7B2 Gene

46,734,827 bp from pter
46,909,267 bp from pter
174,441 bases
Minus strand

Genomic View for COX7B2 Gene

Genes around COX7B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX7B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX7B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX7B2 Gene

Proteins for COX7B2 Gene

  • Protein details for COX7B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome c oxidase subunit 7B2, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q32Q40

    Protein attributes for COX7B2 Gene

    81 amino acids
    Molecular mass:
    9077 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH35923.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI07856.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL75946.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for COX7B2 Gene

Proteomics data for COX7B2 Gene at MOPED

Post-translational modifications for COX7B2 Gene

No Post-translational modifications

Other Protein References for COX7B2 Gene

No data available for DME Specific Peptides for COX7B2 Gene

Domains & Families for COX7B2 Gene

Protein Domains for COX7B2 Gene

Suggested Antigen Peptide Sequences for COX7B2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome c oxidase VIIb family.
  • Belongs to the cytochrome c oxidase VIIb family.
genes like me logo Genes that share domains with COX7B2: view

Function for COX7B2 Gene

Molecular function for COX7B2 Gene

UniProtKB/Swiss-Prot Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
genes like me logo Genes that share phenotypes with COX7B2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for COX7B2 Gene

Localization for COX7B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX7B2 Gene

Mitochondrion inner membrane.

Subcellular locations from

Jensen Localization Image for COX7B2 Gene COMPARTMENTS Subcellular localization image for COX7B2 gene
Compartment Confidence
mitochondrion 5

Gene Ontology (GO) - Cellular Components for COX7B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with COX7B2: view

Pathways & Interactions for COX7B2 Gene

genes like me logo Genes that share pathways with COX7B2: view

Pathways by source for COX7B2 Gene

Interacting Proteins for COX7B2 Gene

Gene Ontology (GO) - Biological Process for COX7B2 Gene


No data available for SIGNOR curated interactions for COX7B2 Gene

Drugs & Compounds for COX7B2 Gene

(2) Additional Compounds for COX7B2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with COX7B2: view

Transcripts for COX7B2 Gene

Unigene Clusters for COX7B2 Gene

Cytochrome c oxidase subunit VIIb2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COX7B2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP2: -

Relevant External Links for COX7B2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COX7B2 Gene

mRNA expression in normal human tissues for COX7B2 Gene

mRNA differential expression in normal tissues according to GTEx for COX7B2 Gene

This gene is overexpressed in Testis (x52.4).

SOURCE GeneReport for Unigene cluster for COX7B2 Gene Hs.479656

genes like me logo Genes that share expression patterns with COX7B2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for COX7B2 Gene

Orthologs for COX7B2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COX7B2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia COX7B2 35
  • 82.92 (n)
  • 73.75 (a)
COX7B2 36
  • 75 (a)
(Pan troglodytes)
Mammalia LOC100615314 35
  • 98.77 (n)
  • 98.77 (a)
COX7B2 36
  • 99 (a)
(Bos Taurus)
Mammalia COX7B 36
  • 71 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 35 (a)
(Mus musculus)
Mammalia Cox7b2 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
(Gallus gallus)
Aves -- 36
  • 48 (a)
Species with no ortholog for COX7B2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for COX7B2 Gene

Gene Tree for COX7B2 (if available)
Gene Tree for COX7B2 (if available)

Paralogs for COX7B2 Gene

Paralogs for COX7B2 Gene

(1) SIMAP similar genes for COX7B2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with COX7B2: view

Variants for COX7B2 Gene

Sequence variations from dbSNP and Humsavar for COX7B2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs201505906 - 46,735,112(+) TTTAC(A/T)TGGCT reference, missense
rs1123700 -- 46,864,083(-) ccctt(G/T)ttgga intron-variant
rs1124442 -- 46,864,234(+) CAGGG(A/G)ATCAC intron-variant
rs1002190 -- 46,861,777(+) cagct(A/G)tgcca intron-variant
rs925479 -- 46,837,351(-) TATAT(C/T)ACTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COX7B2 Gene

Variant ID Type Subtype PubMed ID
dgv5541n71 CNV Loss 21882294
esv2727525 CNV Deletion 23290073
esv2727526 CNV Deletion 23290073
nsv292736 CNV Insertion 16902084
nsv291043 CNV Insertion 16902084
esv2657595 CNV Deletion 23128226
esv273230 CNV Insertion 20981092
esv2450256 CNV Deletion 19546169
esv2410412 CNV Deletion 18987734
esv2666146 CNV Deletion 23128226
nsv879001 CNV Loss 21882294
esv2672767 CNV Deletion 23128226

Variation tolerance for COX7B2 Gene

Residual Variation Intolerance Score: 51.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.98% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for COX7B2 Gene

Disorders for COX7B2 Gene

Relevant External Links for COX7B2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for COX7B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX7B2 Gene

Publications for COX7B2 Gene

  1. A rare polymorphism of the COX7B2 gene in a Cantonese family with nasopharyngeal carcinoma. (PMID: 15623157) Liang H. … Zeng Y. (Sci. China, Ser. C, Life Sci. 2004) 2 3 4 23 67
  2. Genome-wide meta-analysis identifies new susceptibility loci for migraine. (PMID: 23793025) Anttila V. … . (Nat. Genet. 2013) 3
  3. A Genome-Wide Search for Type 2 Diabetes Susceptibility Genes in an Extended Arab Family. (PMID: 23937595) Al Safar H.S. … Blackwell J.M. (Ann. Hum. Genet. 2013) 3
  4. HIV-1 Tat protein directly induces mitochondrial membrane permeabilization and inactivates cytochrome c oxidase. (PMID: 22419111) Lecoeur H. … Jacotot E. (Cell Death Dis 2012) 3
  5. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3

Products for COX7B2 Gene

Sources for COX7B2 Gene