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Aliases for COX7B2 Gene

Aliases for COX7B2 Gene

  • Cytochrome C Oxidase Subunit 7B2 2 3 5
  • Cytochrome C Oxidase Polypeptide VIIb2 4
  • Cytochrome C Oxidase Subunit VIIb2 2

External Ids for COX7B2 Gene

Previous GeneCards Identifiers for COX7B2 Gene

  • GC04M046807
  • GC04M047046
  • GC04M046586
  • GC04M046577
  • GC04M046431
  • GC04M046055

Summaries for COX7B2 Gene

GeneCards Summary for COX7B2 Gene

COX7B2 (Cytochrome C Oxidase Subunit 7B2) is a Protein Coding gene. Among its related pathways are Cardiac muscle contraction and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include cytochrome-c oxidase activity. An important paralog of this gene is COX7B.

UniProtKB/Swiss-Prot for COX7B2 Gene

  • This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX7B2 Gene

Genomics for COX7B2 Gene

Regulatory Elements for COX7B2 Gene

Enhancers for COX7B2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F046993 0.2 Ensembl 11.9 -84.4 -84434 0.2 RNF2 SUZ12 MLLT1 EZH2 COX7B2 GABRB1 GC04M046919
GH04F047010 0.5 Ensembl ENCODE 7.8 -101.9 -101934 0.8 IRF2 BMI1 ZNF316 MAFK MTA2 TRIM22 MAFG JUNB TBX21 EP300 COX7B2 GABRA4 LOC105374442
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around COX7B2 on UCSC Golden Path with GeneCards custom track

Genomic Location for COX7B2 Gene

Chromosome:
4
Start:
46,734,827 bp from pter
End:
46,909,267 bp from pter
Size:
174,441 bases
Orientation:
Minus strand

Genomic View for COX7B2 Gene

Genes around COX7B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX7B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX7B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX7B2 Gene

Proteins for COX7B2 Gene

  • Protein details for COX7B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF08-CX7B2_HUMAN
    Recommended name:
    Cytochrome c oxidase subunit 7B2, mitochondrial
    Protein Accession:
    Q8TF08
    Secondary Accessions:
    • Q32Q40

    Protein attributes for COX7B2 Gene

    Size:
    81 amino acids
    Molecular mass:
    9077 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH35923.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI07856.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL75946.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for COX7B2 Gene

Post-translational modifications for COX7B2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for COX7B2 Gene

Domains & Families for COX7B2 Gene

Protein Domains for COX7B2 Gene

Suggested Antigen Peptide Sequences for COX7B2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TF08

UniProtKB/Swiss-Prot:

CX7B2_HUMAN :
  • Belongs to the cytochrome c oxidase VIIb family.
Family:
  • Belongs to the cytochrome c oxidase VIIb family.
genes like me logo Genes that share domains with COX7B2: view

Function for COX7B2 Gene

Molecular function for COX7B2 Gene

UniProtKB/Swiss-Prot Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Gene Ontology (GO) - Molecular Function for COX7B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 cytochrome-c oxidase activity IEA --
genes like me logo Genes that share ontologies with COX7B2: view
genes like me logo Genes that share phenotypes with COX7B2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for COX7B2 Gene

Localization for COX7B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX7B2 Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COX7B2 Gene COMPARTMENTS Subcellular localization image for COX7B2 gene
Compartment Confidence
mitochondrion 5

Gene Ontology (GO) - Cellular Components for COX7B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IBA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005746 mitochondrial respiratory chain IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with COX7B2: view

Pathways & Interactions for COX7B2 Gene

genes like me logo Genes that share pathways with COX7B2: view

Pathways by source for COX7B2 Gene

Interacting Proteins for COX7B2 Gene

Selected Interacting proteins: Q8TF08-CX7B2_HUMAN for COX7B2 Gene via IID

Symbol External ID(s) Details
CRYZL1

Gene Ontology (GO) - Biological Process for COX7B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1902600 hydrogen ion transmembrane transport IEA,IBA --
genes like me logo Genes that share ontologies with COX7B2: view

No data available for SIGNOR curated interactions for COX7B2 Gene

Drugs & Compounds for COX7B2 Gene

(2) Drugs for COX7B2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with COX7B2: view

Transcripts for COX7B2 Gene

Unigene Clusters for COX7B2 Gene

Cytochrome c oxidase subunit VIIb2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COX7B2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for COX7B2 Gene

GeneLoc Exon Structure for
COX7B2
ECgene alternative splicing isoforms for
COX7B2

Expression for COX7B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for COX7B2 Gene

mRNA differential expression in normal tissues according to GTEx for COX7B2 Gene

This gene is overexpressed in Testis (x52.4).

NURSA nuclear receptor signaling pathways regulating expression of COX7B2 Gene:

COX7B2

SOURCE GeneReport for Unigene cluster for COX7B2 Gene:

Hs.479656
genes like me logo Genes that share expression patterns with COX7B2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for COX7B2 Gene

Orthologs for COX7B2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COX7B2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COX7B2 35
  • 99 (a)
OneToOne
LOC100615314 34
  • 98.77 (n)
dog
(Canis familiaris)
Mammalia COX7B2 34 35
  • 82.92 (n)
cow
(Bos Taurus)
Mammalia COX7B 35
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 63 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cox7b2 35
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 35 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 48 (a)
OneToMany
Species where no ortholog for COX7B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for COX7B2 Gene

ENSEMBL:
Gene Tree for COX7B2 (if available)
TreeFam:
Gene Tree for COX7B2 (if available)

Paralogs for COX7B2 Gene

Paralogs for COX7B2 Gene

(1) SIMAP similar genes for COX7B2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with COX7B2: view

Variants for COX7B2 Gene

Sequence variations from dbSNP and Humsavar for COX7B2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10001459 -- 46,749,524(+) AAAAA(C/T)ATTGT intron-variant
rs10001484 -- 46,749,600(+) TTGCA(A/T)CTGAA intron-variant
rs10005129 -- 46,745,077(+) CATTT(C/T)GCATT intron-variant
rs10006790 -- 46,773,406(+) AAGAC(A/G)TGTTT intron-variant
rs10008793 -- 46,887,323(+) AAAAA(A/T)ATTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COX7B2 Gene

Variant ID Type Subtype PubMed ID
esv2410412 CNV deletion 18987734
esv2450256 CNV deletion 19546169
esv2657595 CNV deletion 23128226
esv2666146 CNV deletion 23128226
esv2672767 CNV deletion 23128226
esv2727525 CNV deletion 23290073
esv2727526 CNV deletion 23290073
esv3308957 CNV mobile element insertion 20981092
esv3393492 CNV insertion 20981092
esv3563820 CNV deletion 23714750
esv3600436 CNV loss 21293372
esv3600438 CNV loss 21293372
esv3600439 CNV loss 21293372
esv3600440 CNV loss 21293372
nsv1123781 CNV deletion 24896259
nsv1136844 CNV deletion 24896259
nsv1161081 CNV duplication 26073780
nsv291043 CNV insertion 16902084
nsv292736 CNV insertion 16902084
nsv594117 CNV loss 21841781
nsv958247 CNV deletion 24416366

Variation tolerance for COX7B2 Gene

Residual Variation Intolerance Score: 51.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COX7B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COX7B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX7B2 Gene

Disorders for COX7B2 Gene

Relevant External Links for COX7B2

Genetic Association Database (GAD)
COX7B2
Human Genome Epidemiology (HuGE) Navigator
COX7B2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COX7B2

No disorders were found for COX7B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX7B2 Gene

Publications for COX7B2 Gene

  1. A rare polymorphism of the COX7B2 gene in a Cantonese family with nasopharyngeal carcinoma. (PMID: 15623157) Liang H. … Zeng Y. (Sci. China, Ser. C, Life Sci. 2004) 2 3 4 22 64
  2. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Genome-wide meta-analysis identifies new susceptibility loci for migraine. (PMID: 23793025) Anttila V. … . (Nat. Genet. 2013) 3 64
  5. A Genome-Wide Search for Type 2 Diabetes Susceptibility Genes in an Extended Arab Family. (PMID: 23937595) Al Safar H.S. … Blackwell J.M. (Ann. Hum. Genet. 2013) 3 64

Products for COX7B2 Gene

Sources for COX7B2 Gene

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