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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COX7B2 Gene

protein-coding   GIFtS: 51
GCID: GC04M046652

cytochrome c oxidase subunit VIIb2
 Explore 5 diseases affiliated with
COX7B2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for COX7B2    

Aliases
for COX7B2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cytochrome C Oxidase Subunit VIIb21 2
Cytochrome C Oxidase Polypeptide VIIb22 3
Cytochrome C Oxidase Subunit 7B2, Mitochondrial2

External Ids:    HGNC: 243811   Entrez Gene: 1707122   Ensembl: ENSG000001705167   OMIM: 6098115   UniProtKB: Q8TF083   

Export aliases for COX7B2 gene to outside databases

Previous GC identifers: GC04M046807 GC04M047046 GC04M046586 GC04M046577 GC04M046431 GC04M046055


Summaries
for COX7B2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CX7B2_HUMAN, Q8TF08
Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in
mitochondrial electron transport




Genomic Views
for COX7B2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006238.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COX7B2 gene promoter:
         Oct-B1   SRF   oct-B3   oct-B2   Pbx1a   SRF (504 AA)   AP-4   POU2F2   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: COX7B2 promoter sequence
   Search SABiosciences Chromatin IP Primers for COX7B2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COX7B2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p12   Ensembl cytogenetic band:  4p12   HGNC cytogenetic band: 4p12

COX7B2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COX7B2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M046652:  view genomic region     (about GC identifiers)

Start:
 46,736,844 bp from pter      End:
 46,911,252 bp from pter
Size:
 174,409 bases      Orientation:
 minus strand

Proteins
for COX7B2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CX7B2_HUMAN, Q8TF08 (See protein sequence)
Recommended Name: Cytochrome c oxidase subunit 7B2, mitochondrial precursor  
Size: 81 amino acids; 9077 Da
Subcellular location: Mitochondrion inner membrane (By similarity)
Sequence caution: Sequence=AAH35923.1; Type=Erroneous initiation; Sequence=AAI07856.1; Type=Erroneous initiation;
Sequence=AAL75946.1; Type=Erroneous initiation;
Secondary accessions: Q32Q40

Explore the universe of human proteins at neXtProt for COX7B2: NX_Q8TF08

COX7B2 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_570972.2  
ENSEMBL proteins: 
 ENSP00000347799   ENSP00000379784   ENSP00000423519   ENSP00000305964   ENSP00000437439  

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Uscn Proteins for COX7B2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005746mitochondrial respiratory chain IEA--
GO:0016021integral to membrane IEA--


COX7B2 for ontologies           About GeneDecksing



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Protein Domains /
Families
for COX7B2 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
COX7B2 for domains           About GeneDecksing

2 InterPro domains/families:
 IPR023272 Cyt_c_oxidase_suVIIB_dom
 IPR008433 Cyt_c_oxidase_suVIIB

Graphical View of Domain Structure for InterPro Entry Q8TF08

ProtoNet protein and cluster: Q8TF08

1 Blocks protein family: IPB008433 Cytochrome C oxidase chain VIIB

UniProtKB/Swiss-Prot: CX7B2_HUMAN, Q8TF08
Similarity: Belongs to the cytochrome c oxidase VIIb family


Function
for COX7B2 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: CX7B2_HUMAN, Q8TF08
Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in
mitochondrial electron transport

miRNA
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Cell Line
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In Situ Assay
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004129cytochrome-c oxidase activity IEA--


COX7B2 for ontologies           About GeneDecksing



Pathways & Interactions
for COX7B2 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Oxidative phosphorylation0.63
Alzheimer's disease0.43
Parkinson's disease0.61
Huntington's disease0.40
2AMPK Enzyme Complex Pathway
AMPK Enzyme Complex Pathway1.00
3Cardiac muscle contraction
Cardiac muscle contraction1.00
4Metabolism
Metabolic pathways0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for COX7B2
    AMPK Enzyme Complex Pathway


5/6         Kegg Pathways  (Kegg details for COX7B2) (see all 6):
    Oxidative phosphorylation
Metabolic pathways
Cardiac muscle contraction
Alzheimer's disease
Parkinson's disease


COX7B2 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COX7B2

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/14 Interacting proteins for COX7B2 (ENSP000003059644) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
InteractantInteraction Details
GeneCardExternal ID(s)
MT-CO1ENSP000003544994STRING: ENSP00000354499
COX5AENSP000003177804STRING: ENSP00000317780
MT-CO2ENSP000003548764STRING: ENSP00000354876
MT-CO3ENSP000003549824STRING: ENSP00000354982
COX6CENSP000002975644STRING: ENSP00000297564
About this table

Drugs & Compounds
for COX7B2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for COX7B2

2 HMDB Compounds for COX7B2    About this table
CompoundSynonyms CAS #PubMed Ids
OxygenOxygen (see all 5)7782-44-7--
WaterDihydrogen oxide (see all 2)7732-18-5--
Search CenterWatch for drugs/clinical trials and news about COX7B2 / CX7B2 

Transcripts
for COX7B2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for COX7B2 gene: 
NM_130902.2  

Unigene Cluster for COX7B2:

Cytochrome c oxidase subunit VIIb2
Hs.479656  [show with all ESTs]
Unigene Representative Sequence: BI829607
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000355591(uc003gxf.3) ENST00000396533(uc010ige.3) ENST00000505102
ENST00000302930 ENST00000543208

miRNA
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Inhib. RNA
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Clone
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Primer
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COX7B2

Additional cDNA sequence: 

AF125109.1 BC035923.1 BC107855.1 

5 DOTS entries:

DT.97783069  DT.311366  DT.92424831  DT.92424835  DT.95365661 

24/46 AceView cDNA sequences (see all 46):

AA971256 AA935137 AA909863 AF125109 AW664696 AI040938 NM_130902 AI025233 
AI419946 BM800781 AA960902 AA910035 BG207061 AA781167 BG207062 BG202327 
BG181654 AI632188 AI653201 BG198733 AW663461 AA890092 AA723824 AW304005 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for COX7B2    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:                                    
SP2:              -                     


ECgene alternative splicing isoforms for COX7B2

Expression
for COX7B2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

COX7B2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAGCACTCT

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

COX7B2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell 
Tissue Anatomical Compartment CellCategory (developmental path)
BoneMandibular ProcessBone
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See COX7B2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COX7B2

SOURCE GeneReport for Unigene cluster: Hs.479656
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Primer
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In Situ
Assay Products: 
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Orthologs
for COX7B2 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for COX7B2 gene from 2/7 species (see all 7)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
mouse
(Mus musculus)		 Mammalia Cox7b25 cytochrome c oxidase subunit VIIb2   --   5 (37.98 cM) 71442824 
chicken
(Gallus gallus)		 Aves --
 Uncharacterized protein
 51(a)
 1 → many
 4(13000791-13001589)


ENSEMBL Gene Tree for COX7B2 (if available)
TreeFam Gene Tree for COX7B2 (if available) 

Paralogs
for COX7B2 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for COX7B2 gene
COX7B2  
1 SIMAP similar gene for COX7B2 using alignment to 2 protein entries:     CX7B2_HUMAN (see all proteins):
COX7B

COX7B2 for paralogs           About GeneDecksing



Genomic Variants
for COX7B2 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for COX7B2
     2 CNVs: 44163 98704
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COX7B2
DNA2.0 Custom Variant and Variant Library Synthesis for COX7B2

Disorders / Diseases
for COX7B2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
COX7B2 for disorders           About GeneDecksing

OMIM gene information: 609811    OMIM disorders: --

5 diseases for COX7B2:    About MalaCards
huntington's disease    parkinson's disease    nasopharyngitis    prostatitis
carcinoma

Human Genome Epidemiology (HuGE) Navigator: COX7B2 (1 document)

Export disorders for COX7B2 gene to outside databases

Publications
for COX7B2 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for COX7B2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with COX7B2)		    Utopia: connect your pdf to the dynamic
world of online information

  1. A rare polymorphism of the COX7B2 gene in a Cantonese family with nasopharyngeal carcinoma. (PubMed id 15623157)1, 2, 3, 9 Liang H.... Zeng Y. (2004)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. HIV-1 Tat protein directly induces mitochondrial membr ane permeabilization and inactivates cytochrome c oxidase. (PubMed id 22419111)1 Lecoeur H....Jacotot E. (2012)
  4. Polymorphisms in mitochondrial genes and prostate can cer risk. (PubMed id 19064571)1 Wang L....Thibodeau S.N. (2008)
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  7. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

External Searches for COX7B2 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing COX7B2 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 170712 HGNC: 24381 AceView: COX7B2 Ensembl:ENSG00000170516 euGenes: HUgn170712
ECgene: COX7B2 Kegg: 170712 H-InvDB: COX7B2

Other Databases showing COX7B2 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing COX7B2 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for COX7B2 Pharmacogenomics, SNPs, Pathways

Intellectual Property
for COX7B2 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for COX7B2 gene:
Search GeneIP for patents involving COX7B2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for COX7B2 gene

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In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

 
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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COX7B2
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 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COX7B2
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COX7B2
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COX7B2
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 GenScript Custom Purified and Recombinant Proteins Services for COX7B2 GenScript cDNA clones with any tag delivered in your preferred vector for COX7B2
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 Regulatory tfbs in COX7B2 promoter
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
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 Browse SwitchGear 3'UTR luciferase reporter plasmids for COX7B2
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX7B2
       
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