Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



COX7B Gene

protein-coding   GIFtS: 61
GCID: GC0XP077154

Cytochrome C Oxidase Subunit VIIb

  See COX7B-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cytochrome C Oxidase Subunit VIIb1 2
Cytochrome C Oxidase Polypeptide VIIb2 3
APLCC2 5
Cytochrome C Oxidase Subunit 7B, Mitochondrial2
Cytochrome-C Oxidase Chain VIIb2

External Ids:    HGNC: 22911   Entrez Gene: 13492   Ensembl: ENSG000001311747   OMIM: 3008855   UniProtKB: P243113   
ORGUL members:         

Export aliases for COX7B gene to outside databases

Previous GC identifers: GC0XP072700 GC0XP074116 GC0XP075196 GC0XP075910 GC0XP076961 GC0XP077041 GC0XP070740


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for COX7B Gene:
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron
transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic
subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The
mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in
the regulation and assembly of the complex. This nuclear gene encodes subunit VIIb, which is highly similar to
bovine COX VIIb protein and is found in all tissues. This gene may have several pseudogenes on chromosomes 1, 2,
20 and 22. (provided by RefSeq, Jun 2011)

GeneCards Summary for COX7B Gene:
COX7B (cytochrome c oxidase subunit VIIb) is a protein-coding gene. Diseases associated with COX7B include aplasia cutis congenita, reticulolinear, with mmicrocephaly, facial dysmorphism and other congenital anomalies. GO annotations related to this gene include cytochrome-c oxidase activity. An important paralog of this gene is COX7B2.

UniProtKB/Swiss-Prot: COX7B_HUMAN, P24311
Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal
oxidase in mitochondrial electron transport. Plays a role in proper central nervous system (CNS) development in
vertebrates

Gene Wiki entry for COX7B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the COX7B gene promoter:
         POU2F1   POU2F1a   TGIF   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOX7B promoter sequence
   Search Chromatin IP Primers for COX7B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COX7B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq21.1   Ensembl cytogenetic band:  Xq21.1   HGNC cytogenetic band: Xq21.1

COX7B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COX7B gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP077154:  view genomic region     (about GC identifiers)

Start:
77,154,935 bp from pter      End:
77,162,870 bp from pter
Size:
7,936 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: COX7B_HUMAN, P24311 (See protein sequence)
Recommended Name: Cytochrome c oxidase subunit 7B, mitochondrial precursor  
Size: 80 amino acids; 9161 Da
Secondary accessions: B2R4M3 Q6ICR1

Explore the universe of human proteins at neXtProt for COX7B: NX_P24311

Explore proteomics data for COX7B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys75
  • Modification sites at PhosphoSitePlus

  • See COX7B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001857.1  
    ENSEMBL proteins: 
     ENSP00000417656  
    Reactome Protein details: P24311

    COX7B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for COX7B
    GenScript Custom Purified and Recombinant Proteins Services for COX7B
    Novus Biologicals COX7B Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for COX7B 

     
    antibodies-online proteins for COX7B (2 products) 

     
    antibodies-online peptides for COX7B

    COX7B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for COX7B
    OriGene Custom Antibody Services for COX7B
    Novus Biologicals COX7B Antibodies
    Abcam antibodies for COX7B
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for COX7B
    antibodies-online antibodies for COX7B (6 products) 

    COX7B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for COX7B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for COX7B
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for COX7B 
    antibodies-online kits for COX7B (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    comIV: Mitochondrial respiratory chain complex / Complex IV

    2 InterPro protein domains:
     IPR023272 Cyt_c_oxidase_suVIIB_dom
     IPR008433 Cyt_c_oxidase_suVIIB

    Graphical View of Domain Structure for InterPro Entry P24311

    ProtoNet protein and cluster: P24311

    1 Blocks protein domain: IPB008433 Cytochrome C oxidase chain VIIB

    UniProtKB/Swiss-Prot: COX7B_HUMAN, P24311
    Similarity: Belongs to the cytochrome c oxidase VIIb family


    Find genes that share domains with COX7B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COX7B_HUMAN, P24311
    Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal
    oxidase in mitochondrial electron transport. Plays a role in proper central nervous system (CNS) development in
    vertebrates

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004129cytochrome-c oxidase activity IEA--
         
    Find genes that share ontologies with COX7B           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for COX7B:
     Increased circadian period len  Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cox7b):
     reproductive system 

    Find genes that share phenotypes with COX7B           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for COX7B

    miRNA
    Products:
        
    miRTarBase miRNAs that target COX7B:
    hsa-mir-17-5p (MIRT050893), hsa-let-7b-5p (MIRT032325), hsa-mir-10a-5p (MIRT047557), hsa-mir-18a-5p (MIRT050687), hsa-mir-18b-5p (MIRT042410)

    Block miRNA regulation of human, mouse, rat COX7B using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate COX7B:
    hsa-miR-607
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for COX7B
    Predesigned siRNA for gene silencing in human, mouse, rat COX7B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for COX7B

    Clone
    Products:
         
    OriGene clones in human, mouse for COX7B (see all 6)
    OriGene ORF clones in mouse, rat for COX7B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COX7B (NM_001866)
    Sino Biological Human cDNA Clone for COX7B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COX7B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX7B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for COX7B
    Browse ESI BIO Cell Lines and PureStem Progenitors for COX7B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX7B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    COX7B_HUMAN, P24311: Mitochondrion inner membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion4

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005746mitochondrial respiratory chain IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with COX7B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for COX7B About    
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Oxidative phosphorylation0.64
    Respiratory electron transport0.81
    Parkinson's disease0.57
    Electron Transport Chain0.75
    Huntington's disease0.45
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Alzheimer's disease
    Alzheimer's disease0.44
    4Cardiac muscle contraction
    Cardiac muscle contraction
    5AMPK Enzyme Complex Pathway
    AMPK Enzyme Complex Pathway


    Find genes that share SuperPaths with COX7B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for COX7B
        AMPK Enzyme Complex Pathway

    1 BioSystems Pathway for COX7B
        Electron Transport Chain


    1 Reactome Pathway for COX7B
        Respiratory electron transport


    Selected Kegg Pathways  (Kegg details for COX7B) (see all 7):
        Oxidative phosphorylation
    Metabolic pathways
    Cardiac muscle contraction
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease

        Pathway & Disease-focused RT2 Profiler PCR Array including COX7B: 
              Mitochondrial Energy Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for COX7B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COX7B (P243113 ENSP000004176564) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYBP102423I2D: score=1 
    COX4I1ENSP000002534524STRING: ENSP00000253452
    COX7A2LENSP000002343014STRING: ENSP00000234301
    COX8AENSP000003212604STRING: ENSP00000321260
    UQCRFS1ENSP000003063974STRING: ENSP00000306397
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007417central nervous system development IMP--
    GO:0022904respiratory electron transport chain TAS--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:1902600hydrogen ion transmembrane transport TAS8382530

    Find genes that share ontologies with COX7B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COX7B

    2 HMDB Compounds for COX7B    About this table
    CompoundSynonyms CAS #PubMed Ids
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for COX7B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cholic Acid-- 81-25-4target--10592235
    N-Formylmethionine-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for COX7B gene: 
    NM_001866.2  

    Unigene Cluster for COX7B:

    Cytochrome c oxidase subunit VIIb
    Hs.522699  [show with all ESTs]
    Unigene Representative Sequence: BG179412
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373335 ENST00000481445(uc004ecu.1) ENST00000475465
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat COX7B using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate COX7B:
    hsa-miR-607
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for COX7B
    Predesigned siRNA for gene silencing in human, mouse, rat COX7B
    Clone
    Products:
         
    OriGene clones in human, mouse for COX7B (see all 6)
    OriGene ORF clones in mouse, rat for COX7B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COX7B (NM_001866)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COX7B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX7B
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for COX7B
    OriGene qSTAR qPCR primer pairs in human, mouse for COX7B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COX7B
      QuantiTect SYBR Green Assays in human, mouse, rat COX7B
      QuantiFast Probe-based Assays in human, mouse, rat COX7B

    Additional mRNA sequence: 

    AK311879.1 BC018386.1 BT009767.1 CR450332.1 CR542124.1 Z14244.1 

    17 DOTS entries:

    DT.452860  DT.95337838  DT.100666783  DT.121301147  DT.95337846  DT.121301169  DT.92441857  DT.97859158 
    DT.101976238  DT.98131771  DT.95337803  DT.100824906  DT.121430977  DT.121635024  DT.92441853  DT.95337835 
    DT.91849803 

    Selected AceView cDNA sequences (see all 344):

    BC018386 BM798949 AI832784 BG032191 N50520 F35499 F25447 CD676950 
    AA328050 CR542124 CD676651 AI250898 BG033616 BM760510 AV682604 AI719097 
    AI799736 AI189185 AW005526 F27273 AI417083 CR450332 BX505966 BM851473 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for COX7B    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5
    SP1:                          -           -         
    SP2:                    -     -           -         
    SP3:                                      -         
    SP4:                    -     -                     


    ECgene alternative splicing isoforms for COX7B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    COX7B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACATATGTA
    COX7B Expression
    About this image


    COX7B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Eye (Sensory Organs)
             Lens
     
     Colon (Gastrointestinal Tract)
     
     Adipose (Muscoskeletal System)
     
     Liver (Hepatobiliary System)
    COX7B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COX7B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522699
        Pathway & Disease-focused RT2 Profiler PCR Array including COX7B: 
              Mitochondrial Energy Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for COX7B
    OriGene qSTAR qPCR primer pairs in human, mouse for COX7B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COX7B
    QuantiTect SYBR Green Assays in human, mouse, rat COX7B
    QuantiFast Probe-based Assays in human, mouse, rat COX7B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX7B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for COX7B gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cox7b1 , 5 cytochrome c oxidase subunit VIIb1, 5 85(n)1
    78.75(a)1
      X (47.36 cM)5
    661421  NM_025379.21  NP_079655.11 
     1060157005 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    54(a)
    1 → many
    4(12862011-12864443)
    African clawed frog
    (Xenopus laevis)
    Amphibia AW635929.12   -- 73.4(n)    AW635929.1 


    ENSEMBL Gene Tree for COX7B (if available)
    TreeFam Gene Tree for COX7B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for COX7B gene
    COX7B22  
    1 SIMAP similar gene for COX7B using alignment to 1 protein entry:     COX7B_HUMAN:
    COX7B2

    Find genes that share paralogs with COX7B           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for COX7B (see all 11)
    PGOHUM00000238476 PGOHUM00000242439 PGOHUM00000242879 PGOHUM00000239744 PGOHUM00000244317


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for COX7B (see all 106)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1836082051,2
    --77124143(+) CAAAAC/TGTTAC 1 -- us2k10--------
    rs1881489351,2
    --77124343(+) GGAGAC/TTGACT 1 -- us2k10--------
    rs1929129151,2
    --77124676(+) AAGCAG/TTTAGT 1 -- us2k10--------
    rs1838247161,2
    --77124791(+) TGGGAC/TAGGTC 1 -- us2k10--------
    rs1866986941,2
    --77124892(+) CTGGGA/GTTAGA 1 -- us2k10--------
    rs1911607261,2
    --77124956(+) TTGCCA/GTGTTG 1 -- us2k10--------
    rs2005627931,2
    C--77124982(+) TCTTT-/TTTTC 
            
    TTTCT
    1 -- us2k10--------
    rs2010634511,2
    --77124999(+) TTCTT-/TTCTTTTT 1 -- us2k10--------
    rs1847958331,2
    --77125032(+) GCTCTA/GTCACC 1 -- us2k10--------
    rs1892582931,2
    --77125155(+) ACGCCC/TAGCTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for COX7B (77154935 - 77162870 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for COX7B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv511668CNV Loss21212237

    Human Gene Mutation Database (HGMD): COX7B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COX7B
    DNA2.0 Custom Variant and Variant Library Synthesis for COX7B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 300885   
    OMIM disorders: 300887  
    UniProtKB/Swiss-Prot: COX7B_HUMAN, P24311
  • Aplasia cutis congenita, reticulolinear, with microcephaly, facial dysmorphism and other congenital
    anomalies (APLCC) [MIM:300887]: A distinct form of aplasia cutis congenita presenting as multiple linear skin
    defects on the face and neck associated with poor growth, microcephaly, and facial dysmorphism. Additional
    features include intellectual disability, nail dystrophy, short stature and cardiac abnormalities. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 1 disease for COX7B:    
    About MalaCards
    aplasia cutis congenita, reticulolinear, with mmicrocephaly, facial dysmorphism and other congenital anomalies


    Find genes that share disorders with COX7B           About GenesLikeMe


    Export disorders for COX7B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for COX7B gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with COX7B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a cDNA specifying subunit VIIb of human cytochrome c oxidase. (PubMed id 8382530)1, 2, 3 Sadlock J.E.... Schon E.A. (Biochim. Biophys. Acta 1993)
    2. Mutations in COX7B cause microphthalmia with linear skin lesions, an unconventional mitochondrial disease. (PubMed id 23122588)1, 2 Indrieri A.... Franco B. (Am. J. Hum. Genet. 2012)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart. (PubMed id 1309697)1, 2 van Kuilenburg A.B.P....Muijsers A.O. (Eur. J. Biochem. 1992)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. Interleukin-24 mediates apoptosis in human B-cells through early activation of cell cycle arrest followed by late induction of the mitochondrial apoptosis pathway. (PubMed id 22860893)1 Hadife N....Dalloul A. (amp 2013)
    8. HIV-1 Tat protein directly induces mitochondrial membrane permeabilization and inactivates cytochrome c oxidase. (PubMed id 22419111)1 Lecoeur H....Jacotot E. (amp 2012)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b. (PubMed id 20307258)1 Fornuskova D....Zeman J. (Biochem. J. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1349 HGNC: 2291 AceView: COX7B Ensembl:ENSG00000131174 euGenes: HUgn1349
    ECgene: COX7B Kegg: 1349 H-InvDB: COX7B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for COX7B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for COX7B gene:
    Search GeneIP for patents involving COX7B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for COX7B   OriGene RNAi products in human, mouse, rat for COX7B  
     OriGene qPCR primer pairs and template standards for COX7B   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for COX7B  
     OriGene qSTAR qPCR primer pairs in human, mouse for COX7B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for COX7B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for COX7B   OriGene Custom Protein Services for COX7B  

     
     
     Block miRNA regulation of human, mouse, rat COX7B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing COX7B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COX7B Predesigned siRNA for gene silencing in human, mouse, rat COX7B
     QuantiFast Probe-based Assays in human, mouse, rat COX7B QuantiTect SYBR Green Assays in human, mouse, rat COX7B
     PCR Arrays including human, mouse, rat COX7B Search Chromatin IP Primers for COX7B
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COX7B  Search GeneGlobe Interaction Network for COX7B
     Regulatory tfbs in COX7B promoter
     GenScript Custom Purified and Recombinant Proteins Services for COX7B GenScript cDNA clones with any tag delivered in your preferred vector for COX7B
     GenScript Custom Assay Services for COX7B GenScript Custom overexpressing Cell Line Services for COX7B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for COX7B
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for COX7B
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     COX7B antibodies
     COX7B proteins
     Antibodies for COX7B
     See all of Abcam's Antibodies, Kits and Proteins for COX7B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for COX7B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX7B
     Browse SwitchGear 3'UTR luciferase reporter plasmids for COX7B
     SwitchGear Promoter luciferase reporter plasmids for COX7B
     ThermoFisher Antibodies for COX7B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX7B
     Browse compounds at ApexBio
     Search Addgene for plasmids for COX7B
      Search eBioscience for proteins for COX7B
      Search eBioscience for elisas for COX7B
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for COX7B
     antibodies-online antibodies for COX7B (6 products)
     antibodies-online kits for COX7B (4 products)
     antibodies-online peptides for COX7B
     antibodies-online proteins for COX7B (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      COX7B gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4