Aliases for COX7A2L Gene
External Ids for COX7A2L Gene
Previous GeneCards Identifiers for COX7A2L Gene
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. [provided by RefSeq, Jul 2008]
GeneCards Summary for COX7A2L Gene
COX7A2L (Cytochrome C Oxidase Subunit VIIa Polypeptide 2 Like) is a Protein Coding gene. Diseases associated with COX7A2L include breast cancer. Among its related pathways are Metabolism and Alzheimers disease. GO annotations related to this gene include electron carrier activity and cytochrome-c oxidase activity. An important paralog of this gene is COX7A2.
UniProtKB/Swiss-Prot for COX7A2L Gene
Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity).