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Aliases for COX7A2L Gene

Aliases for COX7A2L Gene

  • Cytochrome C Oxidase Subunit VIIa Polypeptide 2 Like 2 3
  • COX7RP 3 4 6
  • EB1 3 4 6
  • Cytochrome C Oxidase Subunit VIIa-Related Protein 3 4
  • COX7a-Related Protein 3 4
  • COX7AR 3 4
  • Cytochrome C Oxidase Subunit 7A-Related Protein, Mitochondrial 3
  • Cytochrome C Oxidase Subunit VII-Related Protein 3
  • Estrogen Receptor Binding CpG Island 3
  • SIG81 3

External Ids for COX7A2L Gene

Previous GeneCards Identifiers for COX7A2L Gene

  • GC02M042566
  • GC02M042746
  • GC02M042552
  • GC02M042489

Summaries for COX7A2L Gene

Entrez Gene Summary for COX7A2L Gene

  • Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. [provided by RefSeq, Jul 2008]

GeneCards Summary for COX7A2L Gene

COX7A2L (Cytochrome C Oxidase Subunit VIIa Polypeptide 2 Like) is a Protein Coding gene. Diseases associated with COX7A2L include breast cancer. Among its related pathways are Metabolism and Alzheimers disease. GO annotations related to this gene include electron carrier activity and cytochrome-c oxidase activity. An important paralog of this gene is COX7A2.

UniProtKB/Swiss-Prot for COX7A2L Gene

  • Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity).

Gene Wiki entry for COX7A2L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX7A2L Gene

Genomics for COX7A2L Gene

Regulatory Elements for COX7A2L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COX7A2L Gene

Start:
42,333,546 bp from pter
End:
42,425,088 bp from pter
Size:
91,543 bases
Orientation:
Minus strand

Genomic View for COX7A2L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COX7A2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX7A2L Gene

Proteins for COX7A2L Gene

  • Protein details for COX7A2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14548-COX7R_HUMAN
    Recommended name:
    Cytochrome c oxidase subunit 7A-related protein, mitochondrial
    Protein Accession:
    O14548
    Secondary Accessions:
    • Q9P118

    Protein attributes for COX7A2L Gene

    Size:
    114 amino acids
    Molecular mass:
    12615 Da
    Quaternary structure:
    • Interacts with the mitochondrial respiratory supercomplex.

neXtProt entry for COX7A2L Gene

Proteomics data for COX7A2L Gene at MOPED

Post-translational modifications for COX7A2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COX7A2L Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for COX7A2L Gene

Domains for COX7A2L Gene

Protein Domains for COX7A2L Gene

Graphical View of Domain Structure for InterPro Entry

O14548

UniProtKB/Swiss-Prot:

COX7R_HUMAN :
  • O14548
Family:
  • Belongs to the cytochrome c oxidase VIIa family.
genes like me logo Genes that share domains with COX7A2L: view

No data available for Gene Families for COX7A2L Gene

Function for COX7A2L Gene

Molecular function for COX7A2L Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity).
UniProtKB/Swiss-Prot Induction:
By estrogen

Gene Ontology (GO) - Molecular Function for COX7A2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 cytochrome-c oxidase activity IEA --
GO:0009055 electron carrier activity --
genes like me logo Genes that share ontologies with COX7A2L: view

Phenotypes for COX7A2L Gene

genes like me logo Genes that share phenotypes with COX7A2L: view

Animal Model Products

CRISPR Products

miRNA for COX7A2L Gene

miRTarBase miRNAs that target COX7A2L

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COX7A2L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for COX7A2L Gene

Localization for COX7A2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX7A2L Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COX7A2L Gene COMPARTMENTS Subcellular localization image for COX7A2L gene
Compartment Confidence
mitochondrion 4
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for COX7A2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005746 mitochondrial respiratory chain IEA --
genes like me logo Genes that share ontologies with COX7A2L: view

Pathways for COX7A2L Gene

genes like me logo Genes that share pathways with COX7A2L: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for COX7A2L Gene

Gene Ontology (GO) - Biological Process for COX7A2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0010467 gene expression TAS --
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with COX7A2L: view

Compounds for COX7A2L Gene

(2) HMDB Compounds for COX7A2L Gene

Compound Synonyms Cas Number PubMed IDs
Oxygen
  • Oxygen
7782-44-7
Water
  • Dihydrogen oxide
7732-18-5

(1) Novoseek inferred chemical compound relationships for COX7A2L Gene

Compound -log(P) Hits PubMed IDs
estrogen 31.7 1
genes like me logo Genes that share compounds with COX7A2L: view

Transcripts for COX7A2L Gene

Unigene Clusters for COX7A2L Gene

Cytochrome c oxidase subunit VIIa polypeptide 2 like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COX7A2L

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COX7A2L Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: - - -
SP3: -
SP4: - - - - - - -
SP5: -
SP6: - -

Relevant External Links for COX7A2L Gene

GeneLoc Exon Structure for
COX7A2L
ECgene alternative splicing isoforms for
COX7A2L

Expression for COX7A2L Gene

mRNA expression in normal human tissues for COX7A2L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for COX7A2L Gene

This gene is overexpressed in Frontal cortex (10.7) and Peripheral blood mononuclear cells (9.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COX7A2L Gene

SOURCE GeneReport for Unigene cluster for COX7A2L Gene Hs.339639

genes like me logo Genes that share expressions with COX7A2L: view

Expression partners for COX7A2L Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COX7A2L Gene

Orthologs for COX7A2L Gene

This gene was present in the common ancestor of chordates.

Orthologs for COX7A2L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COX7A2L 35
  • 91.23 (n)
  • 90.35 (a)
COX7A2L 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COX7A2L 35
  • 90.06 (n)
  • 89.47 (a)
COX7A2L 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cox7a2l 35
  • 89.79 (n)
  • 90.99 (a)
Cox7a2l 16
Gm10242 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COX7A2L 35
  • 100 (n)
  • 100 (a)
COX7A2L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cox7a2l 35
  • 87.41 (n)
  • 88.89 (a)
oppossum
(Monodelphis domestica)
Mammalia COX7A2L 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COX7A2L 36
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves COX7A2L 35
  • 71.35 (n)
  • 71.05 (a)
COX7A2L 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COX7A2L 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cox7a2l 35
  • 71.98 (n)
  • 74.34 (a)
Str.8113 35
zebrafish
(Danio rerio)
Actinopterygii cox7a3 35
  • 64.33 (n)
  • 64.91 (a)
wufp89f04 35
cox7a3 36
  • 63 (a)
OneToOne
Species with no ortholog for COX7A2L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COX7A2L Gene

ENSEMBL:
Gene Tree for COX7A2L (if available)
TreeFam:
Gene Tree for COX7A2L (if available)

Paralogs for COX7A2L Gene

Paralogs for COX7A2L Gene

Selected SIMAP similar genes for COX7A2L Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for COX7A2L Gene

genes like me logo Genes that share paralogs with COX7A2L: view

Variants for COX7A2L Gene

Sequence variations from dbSNP and Humsavar for COX7A2L Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1997 -- 42,350,666(+) AATAA(A/T)TACAC utr-variant-3-prime
rs4181 -- 42,350,663(+) GGAAT(-/AAATACACAC)AATTA utr-variant-3-prime
rs8162 -- 42,351,009(-) AGAAA(C/T)GGTGC utr-variant-3-prime
rs1047051 -- 42,350,658(-) ATTCC(A/C)CCGTG utr-variant-3-prime
rs1047124 -- 42,350,585(-) GTGCC(A/C)CAAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for COX7A2L Gene

Variant ID Type Subtype PubMed ID
nsv873970 CNV Gain 21882294
nsv524679 CNV Loss 19592680

Relevant External Links for COX7A2L Gene

HapMap Linkage Disequilibrium report
COX7A2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX7A2L Gene

Disorders for COX7A2L Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for COX7A2L Gene in MalaCards »

(1) Diseases for COX7A2L Gene including...

(1) University of Copenhagen DISEASES for COX7A2L Gene

Relevant External Links for COX7A2L

Genetic Association Database (GAD)
COX7A2L
Human Genome Epidemiology (HuGE) Navigator
COX7A2L
genes like me logo Genes that share disorders with COX7A2L: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for COX7A2L Gene

Publications for COX7A2L Gene

  1. Isolation of estrogen-responsive genes with a CpG island library. (PMID: 9418891) Watanabe T. … Muramatsu M. (Mol. Cell. Biol. 1998) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Molecular evolution of the COX7A gene family in primates. (PMID: 10335655) Schmidt T.R. … Grossman L.I. (Mol. Biol. Evol. 1999) 3 4
  4. A genomewide linkage-disequilibrium scan localizes the Saguenay-Lac- Saint-Jean cytochrome oxidase deficiency to 2p16. (PMID: 11156535) Lee N. … Rioux J.D. (Am. J. Hum. Genet. 2001) 3 4
  5. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 48

Products for COX7A2L Gene

Sources for COX7A2L Gene

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