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Aliases for COX7A2L Gene

Aliases for COX7A2L Gene

  • Cytochrome C Oxidase Subunit 7A2 Like 2 3 5
  • Cytochrome C Oxidase Subunit VIIa Polypeptide 2 Like 2 3
  • Cytochrome C Oxidase Subunit VIIa-Related Protein 3 4
  • COX7a-Related Protein 3 4
  • COX7AR 3 4
  • COX7RP 3 4
  • EB1 3 4
  • Cytochrome C Oxidase Subunit 7A-Related Protein, Mitochondrial 3
  • Cytochrome C Oxidase Subunit VII-Related Protein 3
  • Estrogen Receptor Binding CpG Island 3
  • SIG81 3

External Ids for COX7A2L Gene

Previous GeneCards Identifiers for COX7A2L Gene

  • GC02M042566
  • GC02M042746
  • GC02M042552
  • GC02M042489

Summaries for COX7A2L Gene

Entrez Gene Summary for COX7A2L Gene

  • Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]

GeneCards Summary for COX7A2L Gene

COX7A2L (Cytochrome C Oxidase Subunit 7A2 Like) is a Protein Coding gene. Among its related pathways are Metabolism and Cardiac muscle contraction. GO annotations related to this gene include electron carrier activity and cytochrome-c oxidase activity. An important paralog of this gene is COX7A2.

UniProtKB/Swiss-Prot for COX7A2L Gene

  • Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity).

Gene Wiki entry for COX7A2L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX7A2L Gene

Genomics for COX7A2L Gene

Regulatory Elements for COX7A2L Gene

Enhancers for COX7A2L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F042335 1.1 FANTOM5 Ensembl ENCODE 67.1 +84.8 84761 9.5 PKNOX1 SIN3A ARID4B DMAP1 ZNF48 ZNF143 FOS PAF1 ZNF263 JUNB COX7A2L EML4 LOC102723824 OXER1 GC02M042355 GC02P042307
GH02F042371 0.9 ENCODE 48.8 +53.0 52996 1.7 CTCF HDGF BMI1 ZBTB40 RAD21 POLR2A NR2F6 CREM MAFK MTA2 COX7A2L EML4 HAAO GC02M042355 GC02P042392
GH02F042256 1 Ensembl ENCODE 45.7 +168.3 168319 1.5 PAF1 PKNOX1 ETV6 TBX21 SPI1 COX7A2L EML4 LOC102723824 GC02P042259 GC02M042239
GH02F042419 1.1 Ensembl ENCODE 41.7 +4.1 4141 2.5 KLF1 JUN FEZF1 RAD21 HIC1 ZNF366 SCRT2 NFE2 TRIM24 ZNF600 COX7A2L EML4 LOC105374537 GC02M042414
GH02F042240 0.2 Ensembl 39.9 +183.2 183188 2.2 PAF1 GATA3 ZNF366 ZNF652 COX7A2L EML4 LOC102723824 GC02M042239 GC02P042259
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around COX7A2L on UCSC Golden Path with GeneCards custom track

Genomic Location for COX7A2L Gene

Chromosome:
2
Start:
42,333,546 bp from pter
End:
42,425,088 bp from pter
Size:
91,543 bases
Orientation:
Minus strand

Genomic View for COX7A2L Gene

Genes around COX7A2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX7A2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX7A2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX7A2L Gene

Proteins for COX7A2L Gene

  • Protein details for COX7A2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14548-COX7R_HUMAN
    Recommended name:
    Cytochrome c oxidase subunit 7A-related protein, mitochondrial
    Protein Accession:
    O14548
    Secondary Accessions:
    • Q9P118

    Protein attributes for COX7A2L Gene

    Size:
    114 amino acids
    Molecular mass:
    12615 Da
    Quaternary structure:
    • Interacts with the mitochondrial respiratory supercomplex.

neXtProt entry for COX7A2L Gene

Post-translational modifications for COX7A2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for COX7A2L Gene

Domains & Families for COX7A2L Gene

Protein Domains for COX7A2L Gene

Graphical View of Domain Structure for InterPro Entry

O14548

UniProtKB/Swiss-Prot:

COX7R_HUMAN :
  • Belongs to the cytochrome c oxidase VIIa family.
Family:
  • Belongs to the cytochrome c oxidase VIIa family.
genes like me logo Genes that share domains with COX7A2L: view

No data available for Gene Families for COX7A2L Gene

Function for COX7A2L Gene

Molecular function for COX7A2L Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity).
UniProtKB/Swiss-Prot Induction:
By estrogen.

Gene Ontology (GO) - Molecular Function for COX7A2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 cytochrome-c oxidase activity IEA --
GO:0009055 electron carrier activity IEA --
genes like me logo Genes that share ontologies with COX7A2L: view
genes like me logo Genes that share phenotypes with COX7A2L: view

Animal Model Products

  • Taconic Biosciences Mouse Models for COX7A2L

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COX7A2L Gene

Localization for COX7A2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX7A2L Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COX7A2L Gene COMPARTMENTS Subcellular localization image for COX7A2L gene
Compartment Confidence
mitochondrion 5
nucleus 3
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for COX7A2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IEA,TAS --
GO:0005746 mitochondrial respiratory chain IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with COX7A2L: view

Pathways & Interactions for COX7A2L Gene

genes like me logo Genes that share pathways with COX7A2L: view

Gene Ontology (GO) - Biological Process for COX7A2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen TAS --
GO:1902600 hydrogen ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with COX7A2L: view

No data available for SIGNOR curated interactions for COX7A2L Gene

Drugs & Compounds for COX7A2L Gene

(3) Drugs for COX7A2L Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with COX7A2L: view

Transcripts for COX7A2L Gene

Unigene Clusters for COX7A2L Gene

Cytochrome c oxidase subunit VIIa polypeptide 2 like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COX7A2L Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: - - -
SP3: -
SP4: - - - - - - -
SP5: -
SP6: - -

Relevant External Links for COX7A2L Gene

GeneLoc Exon Structure for
COX7A2L
ECgene alternative splicing isoforms for
COX7A2L

Expression for COX7A2L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for COX7A2L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for COX7A2L Gene

This gene is overexpressed in Frontal cortex (10.7) and Peripheral blood mononuclear cells (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for COX7A2L Gene



Protein tissue co-expression partners for COX7A2L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of COX7A2L Gene:

COX7A2L

SOURCE GeneReport for Unigene cluster for COX7A2L Gene:

Hs.339639
genes like me logo Genes that share expression patterns with COX7A2L: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COX7A2L Gene

Orthologs for COX7A2L Gene

This gene was present in the common ancestor of chordates.

Orthologs for COX7A2L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COX7A2L 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia COX7A2L 34 35
  • 91.23 (n)
dog
(Canis familiaris)
Mammalia COX7A2L 34 35
  • 90.06 (n)
mouse
(Mus musculus)
Mammalia Cox7a2l 34 16
  • 89.79 (n)
Gm10242 35
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cox7a2l 34
  • 87.41 (n)
oppossum
(Monodelphis domestica)
Mammalia COX7A2L 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COX7A2L 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves COX7A2L 34 35
  • 71.35 (n)
lizard
(Anolis carolinensis)
Reptilia COX7A2L 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cox7a2l 34
  • 71.98 (n)
Str.8113 34
zebrafish
(Danio rerio)
Actinopterygii cox7a3 34 35
  • 64.33 (n)
wufp89f04 34
Species where no ortholog for COX7A2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COX7A2L Gene

ENSEMBL:
Gene Tree for COX7A2L (if available)
TreeFam:
Gene Tree for COX7A2L (if available)

Paralogs for COX7A2L Gene

Paralogs for COX7A2L Gene

(3) SIMAP similar genes for COX7A2L Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for COX7A2L Gene

genes like me logo Genes that share paralogs with COX7A2L: view

Variants for COX7A2L Gene

Sequence variations from dbSNP and Humsavar for COX7A2L Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10178208 -- 42,358,314(+) GATGC(C/T)TTTCA intron-variant
rs10179225 -- 42,355,873(+) GGTGC(A/G)CGCCA intron-variant
rs10183278 -- 42,344,346(+) CAACT(C/T)TGTCC intron-variant
rs10187553 -- 42,357,458(+) TACGC(G/T)TCACC intron-variant
rs10189710 -- 42,345,962(+) CCAAC(C/G)TGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COX7A2L Gene

Variant ID Type Subtype PubMed ID
esv3583758 CNV loss 25503493
nsv524679 CNV loss 19592680

Variation tolerance for COX7A2L Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COX7A2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COX7A2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX7A2L Gene

Disorders for COX7A2L Gene

Relevant External Links for COX7A2L

Genetic Association Database (GAD)
COX7A2L
Human Genome Epidemiology (HuGE) Navigator
COX7A2L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COX7A2L

No disorders were found for COX7A2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX7A2L Gene

Publications for COX7A2L Gene

  1. Isolation of estrogen-responsive genes with a CpG island library. (PMID: 9418891) Watanabe T. … Muramatsu M. (Mol. Cell. Biol. 1998) 2 3 4 22 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler H.E. … Kim S.K. (PLoS Genet. 2009) 3 46 64
  4. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for COX7A2L Gene

Sources for COX7A2L Gene

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