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Aliases for COX7A2L Gene

Aliases for COX7A2L Gene

  • Cytochrome C Oxidase Subunit 7A2 Like 2 3
  • Cytochrome C Oxidase Subunit VIIa Polypeptide 2 Like 2 3 5
  • Cytochrome C Oxidase Subunit VIIa-Related Protein 3 4
  • COX7a-Related Protein 3 4
  • COX7AR 3 4
  • COX7RP 3 4
  • EB1 3 4
  • Cytochrome C Oxidase Subunit VII-Related Protein 3
  • Estrogen Receptor Binding CpG Island 3
  • SIG81 3

External Ids for COX7A2L Gene

Previous GeneCards Identifiers for COX7A2L Gene

  • GC02M042566
  • GC02M042746
  • GC02M042552
  • GC02M042489

Summaries for COX7A2L Gene

Entrez Gene Summary for COX7A2L Gene

  • Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]

GeneCards Summary for COX7A2L Gene

COX7A2L (Cytochrome C Oxidase Subunit 7A2 Like) is a Protein Coding gene. Among its related pathways are Gene Expression and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include electron carrier activity and cytochrome-c oxidase activity. An important paralog of this gene is COX7A2.

UniProtKB/Swiss-Prot for COX7A2L Gene

  • Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity).

Gene Wiki entry for COX7A2L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX7A2L Gene

Genomics for COX7A2L Gene

Regulatory Elements for COX7A2L Gene

Enhancers for COX7A2L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around COX7A2L on UCSC Golden Path with GeneCards custom track

Genomic Location for COX7A2L Gene

42,333,546 bp from pter
42,425,088 bp from pter
91,543 bases
Minus strand

Genomic View for COX7A2L Gene

Genes around COX7A2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX7A2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX7A2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX7A2L Gene

Proteins for COX7A2L Gene

  • Protein details for COX7A2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome c oxidase subunit 7A-related protein, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q9P118

    Protein attributes for COX7A2L Gene

    114 amino acids
    Molecular mass:
    12615 Da
    Quaternary structure:
    • Interacts with the mitochondrial respiratory supercomplex.

neXtProt entry for COX7A2L Gene

Proteomics data for COX7A2L Gene at MOPED

Post-translational modifications for COX7A2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for COX7A2L Gene

Domains & Families for COX7A2L Gene

Protein Domains for COX7A2L Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome c oxidase VIIa family.
  • Belongs to the cytochrome c oxidase VIIa family.
genes like me logo Genes that share domains with COX7A2L: view

No data available for Gene Families for COX7A2L Gene

Function for COX7A2L Gene

Molecular function for COX7A2L Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity).
UniProtKB/Swiss-Prot Induction:
By estrogen.
genes like me logo Genes that share phenotypes with COX7A2L: view

Animal Model Products

  • Taconic Biosciences Mouse Models for COX7A2L

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COX7A2L Gene

Localization for COX7A2L Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX7A2L Gene

Mitochondrion inner membrane.

Subcellular locations from

Jensen Localization Image for COX7A2L Gene COMPARTMENTS Subcellular localization image for COX7A2L gene
Compartment Confidence
mitochondrion 5
nucleus 3
cytosol 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for COX7A2L Gene

Pathways & Interactions for COX7A2L Gene

genes like me logo Genes that share pathways with COX7A2L: view

Interacting Proteins for COX7A2L Gene

Gene Ontology (GO) - Biological Process for COX7A2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen TAS --
GO:0022904 respiratory electron transport chain TAS --
GO:0044281 small molecule metabolic process TAS --
GO:1902600 hydrogen ion transmembrane transport TAS 9418891
genes like me logo Genes that share ontologies with COX7A2L: view

No data available for SIGNOR curated interactions for COX7A2L Gene

Drugs & Compounds for COX7A2L Gene

(1) Drugs for COX7A2L Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for COX7A2L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with COX7A2L: view

Transcripts for COX7A2L Gene

Unigene Clusters for COX7A2L Gene

Cytochrome c oxidase subunit VIIa polypeptide 2 like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COX7A2L Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: - - -
SP3: -
SP4: - - - - - - -
SP5: -
SP6: - -

Relevant External Links for COX7A2L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COX7A2L Gene

mRNA expression in normal human tissues for COX7A2L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for COX7A2L Gene

This gene is overexpressed in Frontal cortex (10.7) and Peripheral blood mononuclear cells (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COX7A2L Gene

SOURCE GeneReport for Unigene cluster for COX7A2L Gene Hs.339639

genes like me logo Genes that share expression patterns with COX7A2L: view

Protein tissue co-expression partners for COX7A2L Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COX7A2L Gene

Orthologs for COX7A2L Gene

This gene was present in the common ancestor of chordates.

Orthologs for COX7A2L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia COX7A2L 35
  • 91.23 (n)
  • 90.35 (a)
COX7A2L 36
  • 90 (a)
(Canis familiaris)
Mammalia COX7A2L 35
  • 90.06 (n)
  • 89.47 (a)
COX7A2L 36
  • 89 (a)
(Mus musculus)
Mammalia Cox7a2l 35
  • 89.79 (n)
  • 90.99 (a)
Cox7a2l 16
Gm10242 36
  • 73 (a)
(Pan troglodytes)
Mammalia COX7A2L 35
  • 100 (n)
  • 100 (a)
COX7A2L 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cox7a2l 35
  • 87.41 (n)
  • 88.89 (a)
(Monodelphis domestica)
Mammalia COX7A2L 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia COX7A2L 36
  • 52 (a)
(Gallus gallus)
Aves COX7A2L 35
  • 71.35 (n)
  • 71.05 (a)
COX7A2L 36
  • 69 (a)
(Anolis carolinensis)
Reptilia COX7A2L 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cox7a2l 35
  • 71.98 (n)
  • 74.34 (a)
Str.8113 35
(Danio rerio)
Actinopterygii cox7a3 35
  • 64.33 (n)
  • 64.91 (a)
wufp89f04 35
cox7a3 36
  • 63 (a)
Species with no ortholog for COX7A2L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COX7A2L Gene

Gene Tree for COX7A2L (if available)
Gene Tree for COX7A2L (if available)

Paralogs for COX7A2L Gene

Paralogs for COX7A2L Gene

(3) SIMAP similar genes for COX7A2L Gene using alignment to 5 proteins: Pseudogenes for COX7A2L Gene

genes like me logo Genes that share paralogs with COX7A2L: view

Variants for COX7A2L Gene

Sequence variations from dbSNP and Humsavar for COX7A2L Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1981664 -- 42,350,030(-) TTTCC(C/T)CCAAG downstream-variant-500B
rs3039172 -- 42,350,080(+) AGAGA(-/GG)TATCA downstream-variant-500B
rs1992259 -- 42,369,380(-) ACACT(A/G)TGTAC upstream-variant-2KB
rs1047051 -- 42,350,658(-) ATTCC(A/C)CCGTG utr-variant-3-prime
rs1047124 -- 42,350,585(-) GTGCC(A/C)CAAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for COX7A2L Gene

Variant ID Type Subtype PubMed ID
nsv873970 CNV Gain 21882294
nsv524679 CNV Loss 19592680

Variation tolerance for COX7A2L Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.44% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for COX7A2L Gene

Disorders for COX7A2L Gene

Relevant External Links for COX7A2L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for COX7A2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX7A2L Gene

Publications for COX7A2L Gene

  1. Isolation of estrogen-responsive genes with a CpG island library. (PMID: 9418891) Watanabe T. … Muramatsu M. (Mol. Cell. Biol. 1998) 2 3 4 23 67
  2. Identification of an additional member of the cytochrome c oxidase subunit VIIa family of proteins. (PMID: 8647836) Segade F. … Lazo P.S. (J. Biol. Chem. 1996) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome. (PMID: 26465331) Grose J.H. … Benjamin I.J. (PLoS ONE 2015) 3
  5. TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex. (PMID: 24344204) Guarani V. … Harper J.W. (Mol. Cell. Biol. 2014) 3

Products for COX7A2L Gene

Sources for COX7A2L Gene