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Aliases for COX7A2 Gene

Aliases for COX7A2 Gene

  • Cytochrome C Oxidase Subunit VIIa Polypeptide 2 (Liver) 2 3
  • Cytochrome C Oxidase Subunit VIIa-Liver/Heart 3 4
  • Cytochrome C Oxidase Subunit VIIa-L 3 4
  • Cytochrome C Oxidase Subunit VIIaL 3 4
  • COX7AL 3 4
  • Cytochrome C Oxidase Polypeptide 7A2, Mitochondrial 3
  • Cytochrome C Oxidase Polypeptide VIIa-Liver/Heart 3
  • Cytochrome C Oxidase Subunit 7A2, Mitochondrial 3
  • Hepatic Cytochrome-C Oxidase Chain VIIa 3
  • COXVIIa-L 3
  • COXVIIAL 3
  • COX7AL1 3
  • VIIAL 3

External Ids for COX7A2 Gene

Previous GeneCards Identifiers for COX7A2 Gene

  • GC06M075895
  • GC06M075943
  • GC06M076004
  • GC06M075947
  • GC06M073146

Summaries for COX7A2 Gene

Entrez Gene Summary for COX7A2 Gene

  • Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4 and 14. [provided by RefSeq, Oct 2009]

GeneCards Summary for COX7A2 Gene

COX7A2 (Cytochrome C Oxidase Subunit VIIa Polypeptide 2 (Liver)) is a Protein Coding gene. Diseases associated with COX7A2 include barrett's adenocarcinoma. Among its related pathways are AMPK Enzyme Complex Pathway and Alzheimers disease. GO annotations related to this gene include electron carrier activity and cytochrome-c oxidase activity. An important paralog of this gene is COX7A2L.

UniProtKB/Swiss-Prot for COX7A2 Gene

  • This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Gene Wiki entry for COX7A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX7A2 Gene

Genomics for COX7A2 Gene

Regulatory Elements for COX7A2 Gene

Genomic Location for COX7A2 Gene

Start:
75,237,675 bp from pter
End:
75,250,323 bp from pter
Size:
12,649 bases
Orientation:
Minus strand

Genomic View for COX7A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COX7A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX7A2 Gene

Proteins for COX7A2 Gene

  • Protein details for COX7A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14406-CX7A2_HUMAN
    Recommended name:
    Cytochrome c oxidase subunit 7A2, mitochondrial
    Protein Accession:
    P14406
    Secondary Accessions:
    • B2R5E1
    • Q3MIH5
    • Q5TF59
    • Q6FGI2

    Protein attributes for COX7A2 Gene

    Size:
    83 amino acids
    Molecular mass:
    9396 Da
    Quaternary structure:
    • Interacts with PET100.
    SequenceCaution:
    • Sequence=CAI19899.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for COX7A2 Gene

Proteomics data for COX7A2 Gene at MOPED

Post-translational modifications for COX7A2 Gene

  • Ubiquitination at Lys33 and Lys46
  • Modification sites at PhosphoSitePlus

Other Protein References for COX7A2 Gene

No data available for DME Specific Peptides for COX7A2 Gene

Domains for COX7A2 Gene

Gene Families for COX7A2 Gene

HGNC:
  • comIV :Mitochondrial respiratory chain complex / Complex IV

Protein Domains for COX7A2 Gene

Graphical View of Domain Structure for InterPro Entry

P14406

UniProtKB/Swiss-Prot:

CX7A2_HUMAN :
  • P14406
Family:
  • Belongs to the cytochrome c oxidase VIIa family.
genes like me logo Genes that share domains with COX7A2: view

Function for COX7A2 Gene

Molecular function for COX7A2 Gene

GENATLAS Biochemistry: cytochrome c oxidase,subunit VIIa,polypeptide 2,liver,pseudogene,
UniProtKB/Swiss-Prot Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Gene Ontology (GO) - Molecular Function for COX7A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 cytochrome-c oxidase activity IEA --
GO:0009055 electron carrier activity --
genes like me logo Genes that share ontologies with COX7A2: view

Animal Model Products

CRISPR Products

miRNA for COX7A2 Gene

miRTarBase miRNAs that target COX7A2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COX7A2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for COX7A2 Gene

Localization for COX7A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX7A2 Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COX7A2 Gene COMPARTMENTS Subcellular localization image for COX7A2 gene
Compartment Confidence
mitochondrion 5
nucleus 1

Gene Ontology (GO) - Cellular Components for COX7A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane --
GO:0005746 mitochondrial respiratory chain IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with COX7A2: view

Pathways for COX7A2 Gene

genes like me logo Genes that share pathways with COX7A2: view

Pathways by source for COX7A2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Mitochondrial Energy Metabolism in human,mouse,rat
    • Molecular Toxicology PathwayFinder 384HT in human,mouse,rat

Interacting Proteins for COX7A2 Gene

Gene Ontology (GO) - Biological Process for COX7A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1902600 hydrogen ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with COX7A2: view

Compounds for COX7A2 Gene

(2) HMDB Compounds for COX7A2 Gene

Compound Synonyms Cas Number PubMed IDs
Oxygen
  • Oxygen
7782-44-7
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with COX7A2: view

Transcripts for COX7A2 Gene

Unigene Clusters for COX7A2 Gene

Cytochrome c oxidase subunit VIIa polypeptide 2 (liver):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COX7A2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COX7A2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b
SP1: - - -
SP2: - - -
SP3: - -
SP4: - -
SP5:

Relevant External Links for COX7A2 Gene

GeneLoc Exon Structure for
COX7A2
ECgene alternative splicing isoforms for
COX7A2

Expression for COX7A2 Gene

mRNA expression in normal human tissues for COX7A2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COX7A2 Gene

SOURCE GeneReport for Unigene cluster for COX7A2 Gene Hs.70312

genes like me logo Genes that share expressions with COX7A2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COX7A2 Gene

Orthologs for COX7A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COX7A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COX7A2 35
  • 99.42 (n)
  • 99.13 (a)
COX7A2 36
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COX7A2 35
  • 88.76 (n)
  • 84.34 (a)
COX7A2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COX7A2 36
  • 49 (a)
OneToOne
LOC611134 35
  • 89.96 (n)
  • 86.75 (a)
mouse
(Mus musculus)
Mammalia Cox7a2 35
  • 80.72 (n)
  • 80.72 (a)
Cox7a2 16
Cox7a2 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COX7A2 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COX7A2 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves COX7A2 35
  • 74.3 (n)
  • 69.88 (a)
COX7A2 36
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7570 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cox7a2 35
  • 71.49 (n)
  • 72.29 (a)
Str.16408 35
zebrafish
(Danio rerio)
Actinopterygii CABZ01013938.1 36
  • 57 (a)
OneToMany
cox7a2a 35
  • 58.63 (n)
  • 54.22 (a)
cox7a2a 36
  • 55 (a)
OneToMany
Species with no ortholog for COX7A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COX7A2 Gene

ENSEMBL:
Gene Tree for COX7A2 (if available)
TreeFam:
Gene Tree for COX7A2 (if available)

Paralogs for COX7A2 Gene

Paralogs for COX7A2 Gene

Pseudogenes.org Pseudogenes for COX7A2 Gene

genes like me logo Genes that share paralogs with COX7A2: view

Variants for COX7A2 Gene

Sequence variations from dbSNP and Humsavar for COX7A2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs240418 -- 75,240,546(+) TATTC(C/T)GTCTC intron-variant
rs240419 -- 75,242,003(+) cgaga(A/C)cagcc intron-variant
rs240420 -- 75,242,455(+) gagcc(A/G)agatt intron-variant
rs240421 -- 75,242,981(+) ATACA(A/T)CTTTT intron-variant
rs240422 -- 75,243,504(+) TCCCC(A/T)GCCTC intron-variant

Relevant External Links for COX7A2 Gene

HapMap Linkage Disequilibrium report
COX7A2
Human Gene Mutation Database (HGMD)
COX7A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for COX7A2 Gene

Disorders for COX7A2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for COX7A2 Gene including...

Search for COX7A2 Gene in MalaCards »

Relevant External Links for COX7A2

Genetic Association Database (GAD)
COX7A2
Human Genome Epidemiology (HuGE) Navigator
COX7A2
genes like me logo Genes that share disorders with COX7A2: view

No data available for UniProtKB/Swiss-Prot for COX7A2 Gene

Publications for COX7A2 Gene

  1. Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase. (PMID: 1327965) Arnaudo E. … Schon E.A. (Gene 1992) 2 3 23
  2. Isolation and sequence of the human cytochrome c oxidase subunit VIIaL gene. (PMID: 11004498) Huettemann M. … Kadenbach B. (Biochim. Biophys. Acta 2000) 3 4 23
  3. Sequence of a cDNA specifying subunit VIIa of human cytochrome c oxidase. (PMID: 2550906) Fabrizi G.M. … Schon E.A. (Nucleic Acids Res. 1989) 3 4
  4. Chromosomal localization of the human liver form cytochrome c oxidase subunit VIIa gene. (PMID: 9202412) Merante F. … Robinson B.H. (Genome 1997) 2 3
  5. Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart. (PMID: 1309697) van Kuilenburg A.B.P. … Muijsers A.O. (Eur. J. Biochem. 1992) 3 4

Products for COX7A2 Gene

Sources for COX7A2 Gene

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