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Aliases for COX7A1 Gene

Aliases for COX7A1 Gene

  • Cytochrome C Oxidase Subunit 7A1 2 3
  • Cytochrome C Oxidase Subunit VIIa Polypeptide 1 (Muscle) 2 3 5
  • Cytochrome C Oxidase Subunit VIIa-Muscle 3 4
  • Cytochrome C Oxidase Subunit VIIa-Heart 3 4
  • Cytochrome C Oxidase Subunit VIIa-H 3 4
  • Cytochrome C Oxidase Subunit VIIa-M 3 4
  • COX7AH 3 4
  • Cytochrome C Oxidase Subunit VIIa Heart/Muscle Isoform 3
  • COX7AM 3
  • COX7A 3

External Ids for COX7A1 Gene

Previous HGNC Symbols for COX7A1 Gene

  • COX7A

Previous GeneCards Identifiers for COX7A1 Gene

  • GC19M037280
  • GC19M037090
  • GC19M041317
  • GC19M041333
  • GC19M036641
  • GC19M033149
  • GC19M036327
  • GC19M036702

Summaries for COX7A1 Gene

Entrez Gene Summary for COX7A1 Gene

  • Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (muscle isoform) of subunit VIIa and the polypeptide 1 is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for COX7A1 Gene

COX7A1 (Cytochrome C Oxidase Subunit 7A1) is a Protein Coding gene. Among its related pathways are Alzheimer's disease and Cardiac muscle contraction. GO annotations related to this gene include electron carrier activity and cytochrome-c oxidase activity. An important paralog of this gene is COX7A2.

UniProtKB/Swiss-Prot for COX7A1 Gene

  • This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Gene Wiki entry for COX7A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX7A1 Gene

Genomics for COX7A1 Gene

Regulatory Elements for COX7A1 Gene

Enhancers for COX7A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around COX7A1 on UCSC Golden Path with GeneCards custom track

Promoters for COX7A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COX7A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for COX7A1 Gene

Chromosome:
19
Start:
36,150,922 bp from pter
End:
36,152,869 bp from pter
Size:
1,948 bases
Orientation:
Minus strand

Genomic View for COX7A1 Gene

Genes around COX7A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX7A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX7A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX7A1 Gene

Proteins for COX7A1 Gene

  • Protein details for COX7A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24310-CX7A1_HUMAN
    Recommended name:
    Cytochrome c oxidase subunit 7A1, mitochondrial
    Protein Accession:
    P24310

    Protein attributes for COX7A1 Gene

    Size:
    79 amino acids
    Molecular mass:
    9118 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX7A1 Gene

Proteomics data for COX7A1 Gene at MOPED

Post-translational modifications for COX7A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COX7A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COX7A1 Gene

Domains & Families for COX7A1 Gene

Protein Domains for COX7A1 Gene

Graphical View of Domain Structure for InterPro Entry

P24310

UniProtKB/Swiss-Prot:

CX7A1_HUMAN :
  • Belongs to the cytochrome c oxidase VIIa family.
Family:
  • Belongs to the cytochrome c oxidase VIIa family.
genes like me logo Genes that share domains with COX7A1: view

Function for COX7A1 Gene

Molecular function for COX7A1 Gene

GENATLAS Biochemistry:
cytochrome c oxidase,subunit VIIa,polypeptide 1,heart muscle,with a nuclear respiratory factor 2 (NRF-2) binding site,component of the complex IV,terminal enzyme complex for electron transfert,oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
genes like me logo Genes that share phenotypes with COX7A1: view

Animal Models for COX7A1 Gene

MGI Knock Outs for COX7A1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for COX7A1 Gene

Localization for COX7A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX7A1 Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COX7A1 Gene COMPARTMENTS Subcellular localization image for COX7A1 gene
Compartment Confidence
mitochondrion 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for COX7A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,TAS 9344674
genes like me logo Genes that share ontologies with COX7A1: view

Pathways & Interactions for COX7A1 Gene

genes like me logo Genes that share pathways with COX7A1: view

Pathways by source for COX7A1 Gene

Interacting Proteins for COX7A1 Gene

Gene Ontology (GO) - Biological Process for COX7A1 Gene

None

No data available for SIGNOR curated interactions for COX7A1 Gene

Drugs & Compounds for COX7A1 Gene

(2) Drugs for COX7A1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cholic acid Approved Pharma Full agonist, Agonist, Target 0
N-Formylmethionine Experimental Pharma Target 0

(2) Additional Compounds for COX7A1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with COX7A1: view

Transcripts for COX7A1 Gene

mRNA/cDNA for COX7A1 Gene

Unigene Clusters for COX7A1 Gene

Cytochrome c oxidase subunit VIIa polypeptide 1 (muscle):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COX7A1 Gene

No ASD Table

Relevant External Links for COX7A1 Gene

GeneLoc Exon Structure for
COX7A1
ECgene alternative splicing isoforms for
COX7A1

Expression for COX7A1 Gene

mRNA expression in normal human tissues for COX7A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COX7A1 Gene

This gene is overexpressed in Heart - Left Ventricle (x12.1), Muscle - Skeletal (x10.8), and Heart - Atrial Appendage (x7.8).

Protein differential expression in normal tissues from HIPED for COX7A1 Gene

This gene is overexpressed in Heart (37.0), Esophagus (7.6), and Fetal heart (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for COX7A1 Gene



SOURCE GeneReport for Unigene cluster for COX7A1 Gene Hs.421621

genes like me logo Genes that share expression patterns with COX7A1: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for COX7A1 Gene

Orthologs for COX7A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COX7A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COX7A1 35
  • 83.76 (n)
  • 83.33 (a)
COX7A1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COX7A1 35
  • 83.76 (n)
  • 84.62 (a)
COX7A1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cox7a1 35
  • 76.07 (n)
  • 71.79 (a)
Cox7a1 16
Cox7a1 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COX7A1 35
  • 99.58 (n)
  • 98.73 (a)
COX7A1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COX7A1 36
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cox7a1 36
  • 45 (a)
ManyToMany
Species with no ortholog for COX7A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COX7A1 Gene

ENSEMBL:
Gene Tree for COX7A1 (if available)
TreeFam:
Gene Tree for COX7A1 (if available)

Paralogs for COX7A1 Gene

Paralogs for COX7A1 Gene

(3) SIMAP similar genes for COX7A1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with COX7A1: view

Variants for COX7A1 Gene

Sequence variations from dbSNP and Humsavar for COX7A1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7507569 -- 36,153,029(+) AGTCA(A/G)CGGGG upstream-variant-2KB
rs17879437 -- 36,151,982(+) GGTCC(C/T)GGAAG intron-variant
rs17879731 -- 36,151,972(+) CTGCC(G/T)AGAGG intron-variant
rs17879988 -- 36,151,950(+) GTCTG(C/G)CCTGG intron-variant
rs17882022 -- 36,151,658(+) CCCCC(C/G)GACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COX7A1 Gene

Variant ID Type Subtype PubMed ID
dgv3854n71 CNV Loss 21882294
dgv3855n71 CNV Loss 21882294

Variation tolerance for COX7A1 Gene

Residual Variation Intolerance Score: 55.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COX7A1 Gene

HapMap Linkage Disequilibrium report
COX7A1
Human Gene Mutation Database (HGMD)
COX7A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX7A1 Gene

Disorders for COX7A1 Gene

Relevant External Links for COX7A1

Genetic Association Database (GAD)
COX7A1
Human Genome Epidemiology (HuGE) Navigator
COX7A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COX7A1

No disorders were found for COX7A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX7A1 Gene

Publications for COX7A1 Gene

  1. Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase. (PMID: 1327965) Arnaudo E. … Schon E.A. (Gene 1992) 2 3 4 23 67
  2. Genomic organization and promoter regulation of human cytochrome c oxidase subunit VII heart/muscle isoform (COX7AH). (PMID: 11997101) Yu M. … Grossman L.I. (Biochim. Biophys. Acta 2002) 3 23
  3. The Protein Data Bank. (PMID: 10592235) Berman H.M. … Bourne P.E. (Nucleic Acids Res. 2000) 25 26
  4. Molecular evolution of the COX7A gene family in primates. (PMID: 10335655) Schmidt T.R. … Grossman L.I. (Mol. Biol. Evol. 1999) 3 23
  5. Genomic sequence and organization of the human gene for cytochrome c oxidase subunit (COX7A1) VIIa-M. (PMID: 9344674) Wolz W. … Mueller C.R. (Genomics 1997) 3 23

Products for COX7A1 Gene

Sources for COX7A1 Gene

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