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Aliases for COX6C Gene

Aliases for COX6C Gene

  • Cytochrome C Oxidase Subunit VIc 2 3
  • Cytochrome C Oxidase Polypeptide VIc 4

External Ids for COX6C Gene

Previous GeneCards Identifiers for COX6C Gene

  • GC08M100964
  • GC08M100509
  • GC08M100846
  • GC08M100959
  • GC08M096092
  • GC08M100885

Summaries for COX6C Gene

Entrez Gene Summary for COX6C Gene

  • Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010]

GeneCards Summary for COX6C Gene

COX6C (Cytochrome C Oxidase Subunit VIc) is a Protein Coding gene. Diseases associated with COX6C include prostate cancer. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include cytochrome-c oxidase activity.

UniProtKB/Swiss-Prot for COX6C Gene

  • This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Gene Wiki entry for COX6C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX6C Gene

Genomics for COX6C Gene

Regulatory Elements for COX6C Gene

Genomic Location for COX6C Gene

99,873,200 bp from pter
99,894,062 bp from pter
20,863 bases
Minus strand

Genomic View for COX6C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COX6C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX6C Gene

Proteins for COX6C Gene

  • Protein details for COX6C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome c oxidase subunit 6C
    Protein Accession:
    Secondary Accessions:
    • B2R4D7

    Protein attributes for COX6C Gene

    75 amino acids
    Molecular mass:
    8781 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX6C Gene

Proteomics data for COX6C Gene at MOPED

Post-translational modifications for COX6C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COX6C Gene

No data available for DME Specific Peptides for COX6C Gene

Domains for COX6C Gene

Gene Families for COX6C Gene

  • comIV :Mitochondrial respiratory chain complex / Complex IV

Protein Domains for COX6C Gene


Suggested Antigen Peptide Sequences for COX6C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P09669
  • Belongs to the cytochrome c oxidase subunit 6c family.
genes like me logo Genes that share domains with COX6C: view

Function for COX6C Gene

Molecular function for COX6C Gene

GENATLAS Biochemistry: cytochrome c oxidase,subunit VIc,component of the complex IV,terminal enzyme complex for electron transfer,oxidative phosphorylation (OXPHOS),inner mitochondrial membrane,fused with HMGIC in uterine leiomyoma t(8;12)(q22;q15)
UniProtKB/Swiss-Prot Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Gene Ontology (GO) - Molecular Function for COX6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 cytochrome-c oxidase activity IEA --
genes like me logo Genes that share ontologies with COX6C: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for COX6C Gene

Localization for COX6C Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX6C Gene

Mitochondrion inner membrane.

Subcellular locations from

Jensen Localization Image for COX6C Gene COMPARTMENTS Subcellular localization image for COX6C gene
Compartment Confidence
mitochondrion 5
nucleus 1

Gene Ontology (GO) - Cellular Components for COX6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with COX6C: view

Pathways for COX6C Gene

genes like me logo Genes that share pathways with COX6C: view

Gene Ontology (GO) - Biological Process for COX6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy TAS 2849755
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0010467 gene expression TAS --
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
genes like me logo Genes that share ontologies with COX6C: view

Compounds for COX6C Gene

(2) HMDB Compounds for COX6C Gene

Compound Synonyms Cas Number PubMed IDs
  • Oxygen
  • Dihydrogen oxide

(2) Drugbank Compounds for COX6C Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cholic Acid
81-25-4 target
genes like me logo Genes that share compounds with COX6C: view

Transcripts for COX6C Gene

mRNA/cDNA for COX6C Gene

Unigene Clusters for COX6C Gene

Cytochrome c oxidase subunit VIc:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COX6C Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - - - -
SP6: - -

Relevant External Links for COX6C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COX6C Gene

mRNA expression in normal human tissues for COX6C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COX6C Gene

SOURCE GeneReport for Unigene cluster for COX6C Gene Hs.351875

genes like me logo Genes that share expressions with COX6C: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COX6C Gene

Orthologs for COX6C Gene

This gene was present in the common ancestor of chordates.

Orthologs for COX6C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COX6C 35
  • 99.11 (n)
  • 98.67 (a)
COX6C 36
  • 99 (a)
(Bos Taurus)
Mammalia COX6C 36
  • 73 (a)
(Canis familiaris)
Mammalia -- 36
  • 73 (a)
-- 36
  • 72 (a)
-- 36
  • 72 (a)
(Mus musculus)
Mammalia Cox6c 16
Cox6c 36
  • 72 (a)
LOC102640946 35
  • 80.28 (n)
  • 73.24 (a)
(Monodelphis domestica)
Mammalia COX6C 36
  • 68 (a)
(Rattus norvegicus)
Mammalia LOC100365711 35
  • 77.46 (n)
  • 70.42 (a)
(Gallus gallus)
Aves COX6C 36
  • 61 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21085 35
(Danio rerio)
Actinopterygii cox6c 36
  • 58 (a)
Species with no ortholog for COX6C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COX6C Gene

Gene Tree for COX6C (if available)
Gene Tree for COX6C (if available)

Paralogs for COX6C Gene

genes like me logo Genes that share paralogs with COX6C: view

No data available for Paralogs for COX6C Gene

Variants for COX6C Gene

Sequence variations from dbSNP and Humsavar for COX6C Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1130474 -- 99,892,049(-) AGGTT(A/C/G)GCATA utr-variant-5-prime
rs1130569 -- 99,887,565(-) AACTA(C/T)GATGT reference, synonymous-codon
rs1135382 -- 99,879,402(-) CATTA(C/T)GAATG intron-variant
rs4075507 -- 99,893,723(+) AGCGA(A/G)AACGC utr-variant-5-prime
rs4335107 -- 99,894,623(+) TTCTA(C/T)TCTCT upstream-variant-2KB

Relevant External Links for COX6C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for COX6C Gene

Disorders for COX6C Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for COX6C Gene including...

Search for COX6C Gene in MalaCards »

Relevant External Links for COX6C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with COX6C: view

No data available for UniProtKB/Swiss-Prot for COX6C Gene

Publications for COX6C Gene

  1. Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping. (PMID: 10072584) Hofmann S. … Meitinger T. (Cytogenet. Cell Genet. 1998) 2 3 4 23
  2. Two differentially expressed genes in normal human prostate tissue and in carcinoma. (PMID: 8705997) Wang F.L. … Pardee A.B. (Cancer Res. 1996) 3 23
  3. Nucleotide sequence of cDNA encoding human cytochrome c oxidase subunit VIc. (PMID: 2849755) Otsuka M. … Ohta S. (Nucleic Acids Res. 1988) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for COX6C Gene

Sources for COX6C Gene

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