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COX6C Gene

protein-coding   GIFtS: 57
GCID: GC08M100885

Cytochrome C Oxidase Subunit VIc

  See COX6C-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome C Oxidase Subunit VIc1 2
Cytochrome C Oxidase Polypeptide VIc2 3
Cytochrome C Oxidase Subunit 6C2
Cytochrome C Oxidase Subunit VIc Preprotein2

External Ids:    HGNC: 22851   Entrez Gene: 13452   Ensembl: ENSG000001649197   OMIM: 1240905   UniProtKB: P096693   

Export aliases for COX6C gene to outside databases

Previous GC identifers: GC08M099899 GC08M100964 GC08M100509 GC08M100846 GC08M100959 GC08M096092


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COX6C Gene:
Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer
from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by
mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded
subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and
assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with
mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes
16p12. (provided by RefSeq, Jul 2010)

GeneCards Summary for COX6C Gene:
COX6C (cytochrome c oxidase subunit VIc) is a protein-coding gene. Diseases associated with COX6C include prostate cancer. GO annotations related to this gene include cytochrome-c oxidase activity.

UniProtKB/Swiss-Prot: COX6C_HUMAN, P09669
Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal
oxidase in mitochondrial electron transport

Gene Wiki entry for COX6C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the COX6C gene promoter:
         NF-1   GATA-3   FOXF2   Evi-1   GATA-1   GATA-2   MEF-2A   AREB6   c-Myb   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOX6C promoter sequence
   Search Chromatin IP Primers for COX6C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COX6C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.2   Ensembl cytogenetic band:  8q22.2   HGNC cytogenetic band: 8q22.2

COX6C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COX6C gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M100885:  view genomic region     (about GC identifiers)

Start:
100,885,428 bp from pter      End:
100,906,290 bp from pter
Size:
20,863 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: COX6C_HUMAN, P09669 (See protein sequence)
Recommended Name: Cytochrome c oxidase subunit 6C  
Size: 75 amino acids; 8781 Da
Secondary accessions: B2R4D7

Explore the universe of human proteins at neXtProt for COX6C: NX_P09669

Explore proteomics data for COX6C at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See COX6C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004365.1  
    ENSEMBL proteins: 
     ENSP00000428702   ENSP00000429991   ENSP00000428895   ENSP00000297564   ENSP00000428150  
     ENSP00000429714   ENSP00000429410   ENSP00000428965   ENSP00000429755   ENSP00000429707  
    Reactome Protein details: P09669

    COX6C Human Recombinant Protein Products:

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    Novus Biologicals COX6C Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for COX6C 

     
    antibodies-online proteins for COX6C (2 products) 

     
    Search antibodies-online for peptides for COX6C

    COX6C Antibody Products:

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    antibodies-online antibodies for COX6C (42 products) 

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    antibodies-online kits for COX6C (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    comIV: Mitochondrial respiratory chain complex / Complex IV

    1 InterPro protein domain:
     IPR004204 COX6C

    Graphical View of Domain Structure for InterPro Entry P09669

    ProtoNet protein and cluster: P09669

    1 Blocks protein domain: IPB004204 Cytochrome c oxidase subunit VIc

    UniProtKB/Swiss-Prot: COX6C_HUMAN, P09669
    Similarity: Belongs to the cytochrome c oxidase subunit 6c family


    Find genes that share domains with COX6C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COX6C_HUMAN, P09669
    Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal
    oxidase in mitochondrial electron transport

         Genatlas biochemistry entry for COX6C:
    cytochrome c oxidase,subunit VIc,component of the complex IV,terminal enzyme complex for electron
    transfer,oxidative phosphorylation (OXPHOS),inner mitochondrial membrane,fused with HMGIC in uterine leiomyoma
    t(8;12)(q22;q15)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004129cytochrome-c oxidase activity IEA--
         
    Find genes that share ontologies with COX6C           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for COX6C

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    hsa-miR-873 hsa-miR-605 hsa-miR-4276 hsa-miR-548u
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX6C

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX6C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COX6C_HUMAN, P09669: Mitochondrion inner membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with COX6C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for COX6C About    
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Oxidative phosphorylation0.64
    Respiratory electron transport0.81
    Parkinson's disease0.57
    Electron Transport Chain0.75
    Huntington's disease0.45
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Alzheimer's disease
    Alzheimer's disease0.44
    4Cardiac muscle contraction
    Cardiac muscle contraction
    5AMPK Enzyme Complex Pathway
    AMPK Enzyme Complex Pathway


    Find genes that share SuperPaths with COX6C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for COX6C
        AMPK Enzyme Complex Pathway

    1 BioSystems Pathway for COX6C
        Electron Transport Chain


    1 Reactome Pathway for COX6C
        Respiratory electron transport


    Selected Kegg Pathways  (Kegg details for COX6C) (see all 7):
        Oxidative phosphorylation
    Metabolic pathways
    Cardiac muscle contraction
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease

        Pathway & Disease-focused RT2 Profiler PCR Array including COX6C: 
              Mitochondrial Energy Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for COX6C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COX6C (P096693 ENSP000002975644) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MT-CO2P004033, ENSP000003548764I2D: score=1 STRING: ENSP00000354876
    NELFCDQ8IXH73, ENSP000003423004I2D: score=1 STRING: ENSP00000342300
    PTNP212463I2D: score=4 
    GTF2F2P139843I2D: score=1 
    PHBP352323I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006091generation of precursor metabolites and energy TAS2849755
    GO:0022904respiratory electron transport chain TAS--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with COX6C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COX6C

    2 HMDB Compounds for COX6C    About this table
    CompoundSynonyms CAS #PubMed Ids
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for COX6C    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cholic Acid-- 81-25-4target--10592235
    N-Formylmethionine-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for COX6C gene: 
    NM_004374.3  

    Unigene Cluster for COX6C:

    Cytochrome c oxidase subunit VIc
    Hs.351875  [show with all ESTs]
    Unigene Representative Sequence: AK128382
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000522934 ENST00000520517 ENST00000520468(uc003yiy.2) ENST00000297564
    ENST00000606245 ENST00000520271 ENST00000517682 ENST00000524245 ENST00000522940
    ENST00000518171 ENST00000523016
    miRNA
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    hsa-miR-873 hsa-miR-605 hsa-miR-4276 hsa-miR-548u
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat COX6C

    Additional mRNA sequence: 

    AK123472.1 AK128382.1 AK311791.1 BC000187.2 BT007007.1 S82616.1 X13238.1 

    Selected DOTS entries (see all 27):

    DT.100880926  DT.92324091  DT.75178076  DT.101955426  DT.100690599  DT.91762899  DT.121490189  DT.97860512 
    DT.91880888  DT.95232349  DT.121490283  DT.121490262  DT.121490285  DT.100688154  DT.100690601  DT.100042166 
    DT.100880927  DT.121490347  DT.100042156  DT.95235750  DT.97823876  DT.100042163  DT.100880928  DT.219832 

    Selected AceView cDNA sequences (see all 529):

    AA315205 AI625969 AI088787 BM759333 BE786693 BM090869 AK123472 AI146281 
    F34611 BE385421 F27007 F26642 N22108 AI217618 BU633325 F28675 
    BQ011833 CB409440 AA363360 F29448 W69128 F29160 AI041199 N98683 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for COX6C (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
    SP1:                    -     -     -     -                       -     -         
    SP2:                    -     -     -     -                       -               
    SP3:                                      -                       -     -         
    SP4:                                                              -     -         
    SP5:                    -     -     -     -                                       


    ECgene alternative splicing isoforms for COX6C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COX6C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATATGTGGG
    COX6C Expression
    About this image


    COX6C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    COX6C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COX6C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.351875
        Pathway & Disease-focused RT2 Profiler PCR Array including COX6C: 
              Mitochondrial Energy Metabolism in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX6C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for COX6C gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cox6c5
    LOC1026409461
    cytochrome c oxidase, subunit VIc5
    cytochrome c oxidase subunit 6C-like1
    80.28(n)1
    73.24(a)1
      15 (14.46 cM)5
    1026409461  XM_006516421.11  XP_006516484.11 
     359258865 
    chicken
    (Gallus gallus)
    Aves COX6C6
    Gallus gallus cytochrome c oxidase subunit VIc (CO...
    61(a)
    1 ↔ 1
    2(128069939-128075639)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.210852 Xenopus laevis transcribed sequence with weak similarity more 73.3(n)    BU901473.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cox6c6
    cytochrome c oxidase subunit VIc
    58(a)
    1 ↔ 1
    6(52186260-52192348) ENSDARG00000038577


    ENSEMBL Gene Tree for COX6C (if available)
    TreeFam Gene Tree for COX6C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for COX6C gene

    Find genes that share paralogs with COX6C           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for COX6C (see all 25)
    PGOHUM00000251233 PGOHUM00000251250 PGOHUM00000242552 PGOHUM00000242587 PGOHUM00000242650


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COX6C (see all 386)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1388006661,2
    C--100890332(+) TAAGTA/GCCCTG 1 -- ut310--------
    rs1430022261,2
    --100890410(+) GAACTA/GTTTCT 1 -- ut310--------
    rs1828648711,2
    C--100890431(+) ATTCAC/TGTGTC 1 -- ut310--------
    rs46265651,2
    C,F,A,H--100890542(+) CTCAAT/CACTCA 1 -- int129Minor allele frequency- C:0.25EA NA NS WA CSA 2570
    rs756679731,2
    C,F--100890670(+) CTTTAC/TGCTCC 1 -- int11Minor allele frequency- T:0.01EA 120
    rs567236941,2
    C--100890789(+) TTCTAC/TGCCCA 1 -- int10--------
    rs78444391,2
    C,F,A,H--100890795(+) GCCCAC/ACACCG 1 -- int123Minor allele frequency- A:0.26NS EA NA WA CSA 2349
    rs1145522831,2
    C,F--100890870(+) TTCCTG/CTCTCC 1 -- int11Minor allele frequency- C:0.09WA 118
    rs746247911,2
    --100890875(+) GTCTCC/TAAATA 1 -- int10--------
    rs346881851,2
    C--100890891(+) TCTCA-/AT/   
       T
    /TAC
    ACAGG
    2 -- int1 cds11NA 2

    HapMap Linkage Disequilibrium report for COX6C (100885428 - 100906290 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for COX6C: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing COX6C
    DNA2.0 Custom Variant and Variant Library Synthesis for COX6C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 124090    OMIM disorders: --

    1 disease for COX6C:    
    About MalaCards
    prostate cancer


    Find genes that share disorders with COX6C           About GenesLikeMe

    Genetic Association Database (GAD): COX6C
    Human Genome Epidemiology (HuGE) Navigator: COX6C (2 documents)

    Export disorders for COX6C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COX6C gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with COX6C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping. (PubMed id 10072584)1, 2, 3, 9 Hofmann S.... Meitinger T. (Cytogenet. Cell Genet. 1998)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Polymorphisms in mitochondrial genes and prostate cancer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (amp 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Nucleotide sequence of cDNA encoding human cytochrome c oxidase subunit VIc. (PubMed id 2849755)1, 2 Otsuka M.... Ohta S. (Nucleic Acids Res. 1988)
    6. Two differentially expressed genes in normal human prostate tissue and in carcinoma. (PubMed id 8705997)1, 9 Wang F.L....Pardee A.B. (Cancer Res. 1996)
    7. Interleukin-24 mediates apoptosis in human B-cells through early activation of cell cycle arrest followed by late induction of the mitochondrial apoptosis pathway. (PubMed id 22860893)1 Hadife N....Dalloul A. (amp 2013)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. HIV-1 Tat protein directly induces mitochondrial membrane permeabilization and inactivates cytochrome c oxidase. (PubMed id 22419111)1 Lecoeur H....Jacotot E. (amp 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1345 HGNC: 2285 AceView: COX6C Ensembl:ENSG00000164919 euGenes: HUgn1345
    ECgene: COX6C Kegg: 1345 H-InvDB: COX6C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for COX6C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for COX6C Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for COX6C gene:
    Search GeneIP for patents involving COX6C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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