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Aliases for COX6C Gene

Aliases for COX6C Gene

  • Cytochrome C Oxidase Subunit 6C 2 3 5
  • Cytochrome C Oxidase Polypeptide VIc 4
  • Cytochrome C Oxidase Subunit VIc 2

External Ids for COX6C Gene

Previous GeneCards Identifiers for COX6C Gene

  • GC08M100964
  • GC08M100509
  • GC08M100846
  • GC08M100959
  • GC08M096092
  • GC08M100885

Summaries for COX6C Gene

Entrez Gene Summary for COX6C Gene

  • Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010]

GeneCards Summary for COX6C Gene

COX6C (Cytochrome C Oxidase Subunit 6C) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include cytochrome-c oxidase activity.

UniProtKB/Swiss-Prot for COX6C Gene

  • This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Gene Wiki entry for COX6C Gene

Additional gene information for COX6C Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX6C Gene

Genomics for COX6C Gene

Regulatory Elements for COX6C Gene

Enhancers for COX6C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H099891 1.1 ENCODE 0.7 +0.8 844 2.7 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 ZNF143 VPS13B PABPC1 OSR2 ANKRD46 COX6C GC08M099806
GH08H099858 1.1 Ensembl ENCODE 0.3 +32.7 32729 4.9 CTCF RB1 FEZF1 RAD21 CC2D1A ZFHX2 SMC3 ZNF143 FOS ZSCAN29 ENSG00000253912 ENSG00000253539 RGS22 VPS13B COX6C GC08M099806
GH08H099903 0.8 ENCODE 0.4 -10.9 -10926 2.2 PKNOX1 ESRRA NFIB TAL1 NFXL1 ZBTB40 RFX5 ZKSCAN1 CTBP1 GATA3 RGS22 MIR1273A VPS13B COX6C PIR32500
GH08H099874 0.7 ENCODE 0.4 +19.9 19875 0.2 JUN NR2F1 FEZF1 ZEB2 ATF2 OSR2 HIC1 PRDM6 ZNF629 FOS COX6C GC08M099806
GH08H099869 0.8 ENCODE 0.3 +24.4 24444 0.9 PKNOX1 FEZF1 ZIC2 CTBP1 ZBTB48 ZNF366 ZSCAN5C ZNF639 ZNF10 OVOL3 VPS13B COX6C GC08M099806
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around COX6C on UCSC Golden Path with GeneCards custom track

Promoters for COX6C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000227876 762 1801 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Locations for COX6C Gene

Genomic Locations for COX6C Gene
20,863 bases
Minus strand

Genomic View for COX6C Gene

Genes around COX6C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX6C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX6C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX6C Gene

Proteins for COX6C Gene

  • Protein details for COX6C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome c oxidase subunit 6C
    Protein Accession:
    Secondary Accessions:
    • B2R4D7

    Protein attributes for COX6C Gene

    75 amino acids
    Molecular mass:
    8781 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX6C Gene

Post-translational modifications for COX6C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for COX6C Gene

Domains & Families for COX6C Gene

Gene Families for COX6C Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted membrane proteins

Protein Domains for COX6C Gene

Suggested Antigen Peptide Sequences for COX6C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome c oxidase subunit 6c family.
  • Belongs to the cytochrome c oxidase subunit 6c family.
genes like me logo Genes that share domains with COX6C: view

Function for COX6C Gene

Molecular function for COX6C Gene

GENATLAS Biochemistry:
cytochrome c oxidase,subunit VIc,component of the complex IV,terminal enzyme complex for electron transfer,oxidative phosphorylation (OXPHOS),inner mitochondrial membrane,fused with HMGIC in uterine leiomyoma t(8;12)(q22;q15)
UniProtKB/Swiss-Prot Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Phenotypes From GWAS Catalog for COX6C Gene

Gene Ontology (GO) - Molecular Function for COX6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 cytochrome-c oxidase activity IEA --
genes like me logo Genes that share ontologies with COX6C: view
genes like me logo Genes that share phenotypes with COX6C: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for COX6C Gene

Localization for COX6C Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX6C Gene

Mitochondrion inner membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COX6C gene
Compartment Confidence
mitochondrion 5
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for COX6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with COX6C: view

Pathways & Interactions for COX6C Gene

genes like me logo Genes that share pathways with COX6C: view

Gene Ontology (GO) - Biological Process for COX6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy TAS 2849755
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen TAS --
GO:1902600 hydrogen ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with COX6C: view

No data available for SIGNOR curated interactions for COX6C Gene

Drugs & Compounds for COX6C Gene

(4) Drugs for COX6C Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cholic acid Approved Pharma Full agonist, Agonist, Target 0
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
N-Formylmethionine Experimental Pharma Target 0
genes like me logo Genes that share compounds with COX6C: view

Transcripts for COX6C Gene

Unigene Clusters for COX6C Gene

Cytochrome c oxidase subunit VIc:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for COX6C Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - - - -
SP6: - -

Relevant External Links for COX6C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COX6C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COX6C Gene

Protein differential expression in normal tissues from HIPED for COX6C Gene

This gene is overexpressed in Nasal epithelium (20.6) and Heart (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for COX6C Gene

Protein tissue co-expression partners for COX6C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of COX6C Gene:


SOURCE GeneReport for Unigene cluster for COX6C Gene:


Evidence on tissue expression from TISSUES for COX6C Gene

  • Nervous system(4.8)
  • Eye(4.4)
  • Heart(3.4)
  • Muscle(3.3)
  • Liver(2.6)
  • Adrenal gland(2.4)
  • Gall bladder(2.4)
  • Intestine(2.4)
  • Kidney(2.4)
  • Lung(2.4)
  • Lymph node(2.4)
  • Pancreas(2.4)
  • Skin(2.4)
  • Spleen(2.4)
  • Stomach(2.4)
  • Thyroid gland(2.4)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with COX6C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for COX6C Gene

Orthologs for COX6C Gene

This gene was present in the common ancestor of chordates.

Orthologs for COX6C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COX6C 33 34
  • 99.11 (n)
(Mus musculus)
Mammalia LOC102640946 33
  • 80.28 (n)
Cox6c 34
  • 72 (a)
Gm6265 16
(Rattus norvegicus)
Mammalia LOC100365711 33
  • 77.46 (n)
(Bos Taurus)
Mammalia COX6C 34
  • 73 (a)
(Canis familiaris)
Mammalia -- 34
  • 73 (a)
-- 34
  • 72 (a)
-- 34
  • 72 (a)
(Monodelphis domestica)
Mammalia COX6C 34
  • 68 (a)
(Gallus gallus)
Aves COX6C 34
  • 61 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21085 33
(Danio rerio)
Actinopterygii cox6c 34
  • 58 (a)
Species where no ortholog for COX6C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COX6C Gene

Gene Tree for COX6C (if available)
Gene Tree for COX6C (if available)

Paralogs for COX6C Gene

No data available for Paralogs for COX6C Gene

Variants for COX6C Gene

Sequence variations from dbSNP and Humsavar for COX6C Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10106711 Likely benign 99,877,598(+) TGTCA(G/T)TTTTT downstream-variant-500B
rs1000022837 -- 99,893,236(+) CTTGC(A/G)CCTCA intron-variant
rs1000201937 -- 99,889,270(+) CATCT(C/T)CTCTT intron-variant
rs1000228261 -- 99,883,478(+) TTTTT(C/T)TTTGG intron-variant
rs1000883175 -- 99,892,542(+) TAATA(A/G)AAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COX6C Gene

Variant ID Type Subtype PubMed ID
nsv476777 CNV novel sequence insertion 20440878
esv3891449 CNV loss 25118596

Variation tolerance for COX6C Gene

Residual Variation Intolerance Score: 54.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.92; 87.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COX6C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX6C Gene

Disorders for COX6C Gene

Relevant External Links for COX6C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for COX6C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX6C Gene

Publications for COX6C Gene

  1. Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping. (PMID: 10072584) Hofmann S … Meitinger T (Cytogenetics and cell genetics 1998) 2 3 4 22 60
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  3. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L … Thibodeau SN (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 45 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Two differentially expressed genes in normal human prostate tissue and in carcinoma. (PMID: 8705997) Wang FL … Pardee AB (Cancer research 1996) 3 22 60

Products for COX6C Gene

Sources for COX6C Gene

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