Free for academic non-profit institutions. Other users need a Commercial license

Aliases for COX6C Gene

Aliases for COX6C Gene

  • Cytochrome C Oxidase Subunit 6C 2 3 5
  • Cytochrome C Oxidase Polypeptide VIc 4
  • Cytochrome C Oxidase Subunit VIc 2

External Ids for COX6C Gene

Previous GeneCards Identifiers for COX6C Gene

  • GC08M100964
  • GC08M100509
  • GC08M100846
  • GC08M100959
  • GC08M096092
  • GC08M100885

Summaries for COX6C Gene

Entrez Gene Summary for COX6C Gene

  • Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010]

GeneCards Summary for COX6C Gene

COX6C (Cytochrome C Oxidase Subunit 6C) is a Protein Coding gene. Among its related pathways are Metabolism and Cardiac muscle contraction. GO annotations related to this gene include cytochrome-c oxidase activity.

UniProtKB/Swiss-Prot for COX6C Gene

  • This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Gene Wiki entry for COX6C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX6C Gene

Genomics for COX6C Gene

Regulatory Elements for COX6C Gene

Enhancers for COX6C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F099891 0.2 ENCODE 0.8 +0.8 844 2.7 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 ENSG00000253180 PABPC1 POLR2K VPS13B ENSG00000271930 OSR2 ANKRD46 COX6C GC08M099806
GH08F099903 0.6 ENCODE 0.4 -10.9 -10926 2.2 PKNOX1 SIN3A ZBTB40 RAD21 FOS EGR2 GATAD2B MBD2 SMARCA4 ZBTB33 RGS22 MIR1273A VPS13B COX6C PIR32500
GH08F099875 0.2 ENCODE 0.3 +17.7 17680 1.5 HDGF YBX3 GATA3 NONO ZNF687 ZNF366 ZNF512 ZBTB33 ZKSCAN1 OSR2 RGS22 VPS13B COX6C GC08M099806
GH08F099874 0.8 ENCODE 0.3 +19.9 19875 0.2 MTA2 NR2F1 JUN FEZF1 ZEB2 ZIC2 ZBTB7A ATF2 HIC1 OSR2 COX6C GC08M099806
GH08F099867 0.2 ENCODE 0.3 +26.1 26132 0.0 COX6C GC08M099806
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around COX6C on UCSC Golden Path with GeneCards custom track

Promoters for COX6C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001397517 962 2201 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9

Genomic Location for COX6C Gene

Chromosome:
8
Start:
99,873,200 bp from pter
End:
99,894,062 bp from pter
Size:
20,863 bases
Orientation:
Minus strand

Genomic View for COX6C Gene

Genes around COX6C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX6C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX6C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX6C Gene

Proteins for COX6C Gene

  • Protein details for COX6C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09669-COX6C_HUMAN
    Recommended name:
    Cytochrome c oxidase subunit 6C
    Protein Accession:
    P09669
    Secondary Accessions:
    • B2R4D7

    Protein attributes for COX6C Gene

    Size:
    75 amino acids
    Molecular mass:
    8781 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX6C Gene

Post-translational modifications for COX6C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for COX6C Gene

Domains & Families for COX6C Gene

Protein Domains for COX6C Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for COX6C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P09669

UniProtKB/Swiss-Prot:

COX6C_HUMAN :
  • Belongs to the cytochrome c oxidase subunit 6c family.
Family:
  • Belongs to the cytochrome c oxidase subunit 6c family.
genes like me logo Genes that share domains with COX6C: view

Function for COX6C Gene

Molecular function for COX6C Gene

GENATLAS Biochemistry:
cytochrome c oxidase,subunit VIc,component of the complex IV,terminal enzyme complex for electron transfer,oxidative phosphorylation (OXPHOS),inner mitochondrial membrane,fused with HMGIC in uterine leiomyoma t(8;12)(q22;q15)
UniProtKB/Swiss-Prot Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Gene Ontology (GO) - Molecular Function for COX6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 cytochrome-c oxidase activity IEA --
genes like me logo Genes that share ontologies with COX6C: view
genes like me logo Genes that share phenotypes with COX6C: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for COX6C Gene

Localization for COX6C Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX6C Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COX6C Gene COMPARTMENTS Subcellular localization image for COX6C gene
Compartment Confidence
mitochondrion 5

Gene Ontology (GO) - Cellular Components for COX6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with COX6C: view

Pathways & Interactions for COX6C Gene

genes like me logo Genes that share pathways with COX6C: view

Gene Ontology (GO) - Biological Process for COX6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy TAS 2849755
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen TAS --
GO:1902600 hydrogen ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with COX6C: view

No data available for SIGNOR curated interactions for COX6C Gene

Drugs & Compounds for COX6C Gene

(4) Drugs for COX6C Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cholic acid Approved Pharma Full agonist, Agonist, Target 0
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
N-Formylmethionine Experimental Pharma Target 0
genes like me logo Genes that share compounds with COX6C: view

Transcripts for COX6C Gene

Unigene Clusters for COX6C Gene

Cytochrome c oxidase subunit VIc:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COX6C Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - - - -
SP6: - -

Relevant External Links for COX6C Gene

GeneLoc Exon Structure for
COX6C
ECgene alternative splicing isoforms for
COX6C

Expression for COX6C Gene

mRNA expression in normal human tissues for COX6C Gene

Protein differential expression in normal tissues from HIPED for COX6C Gene

This gene is overexpressed in Nasal epithelium (20.6) and Heart (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for COX6C Gene



Protein tissue co-expression partners for COX6C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of COX6C Gene:

COX6C

SOURCE GeneReport for Unigene cluster for COX6C Gene:

Hs.351875
genes like me logo Genes that share expression patterns with COX6C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COX6C Gene

Orthologs for COX6C Gene

This gene was present in the common ancestor of chordates.

Orthologs for COX6C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COX6C 34 35
  • 99.11 (n)
mouse
(Mus musculus)
Mammalia LOC102640946 34
  • 80.28 (n)
Cox6c 35
  • 72 (a)
OneToOne
Gm6265 16
rat
(Rattus norvegicus)
Mammalia LOC100365711 34
  • 77.46 (n)
cow
(Bos Taurus)
Mammalia COX6C 35
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 73 (a)
OneToMany
-- 35
  • 72 (a)
OneToMany
-- 35
  • 72 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia COX6C 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves COX6C 35
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21085 34
zebrafish
(Danio rerio)
Actinopterygii cox6c 35
  • 58 (a)
OneToOne
Species where no ortholog for COX6C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COX6C Gene

ENSEMBL:
Gene Tree for COX6C (if available)
TreeFam:
Gene Tree for COX6C (if available)

Paralogs for COX6C Gene

No data available for Paralogs for COX6C Gene

Variants for COX6C Gene

Sequence variations from dbSNP and Humsavar for COX6C Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10094411 -- 99,883,471(+) TATAt(A/T)ttttt intron-variant
rs10106711 -- 99,877,598(+) TGTCA(G/T)TTTTT downstream-variant-500B
rs10464840 -- 99,880,056(+) ACTAA(C/T)GCATA intron-variant
rs111320394 -- 99,879,888(+) ACCAT(C/G)GCATG intron-variant
rs111339499 -- 99,887,124(+) GCTCA(A/G)AACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COX6C Gene

Variant ID Type Subtype PubMed ID
esv3891449 CNV loss 25118596
nsv476777 CNV novel sequence insertion 20440878

Variation tolerance for COX6C Gene

Residual Variation Intolerance Score: 54.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.92; 87.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COX6C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COX6C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX6C Gene

Disorders for COX6C Gene

Relevant External Links for COX6C

Genetic Association Database (GAD)
COX6C
Human Genome Epidemiology (HuGE) Navigator
COX6C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COX6C

No disorders were found for COX6C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX6C Gene

Publications for COX6C Gene

  1. Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping. (PMID: 10072584) Hofmann S. … Meitinger T. (Cytogenet. Cell Genet. 1998) 2 3 4 22 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Two differentially expressed genes in normal human prostate tissue and in carcinoma. (PMID: 8705997) Wang F.L. … Pardee A.B. (Cancer Res. 1996) 3 22 64

Products for COX6C Gene

Sources for COX6C Gene

Content
Loading form....