Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

COX6B2 Gene

protein-coding GIFtS: 51
GCID: GC19M055861

cytochrome c oxidase subunit VIb polypeptide 2 (testis)

Explore 2 diseases affiliated with
COX6B2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cytochrome C Oxidase Subunit VIb Polypeptide 2 (Testis)¹ ²		FLJ32865¹
CT59¹ ² ³		Cytochrome C Oxidase Subunit 6B2²
COXVIB2¹ ²		Cytochrome C Oxidase Subunit VIb, Testes Specific²
Cancer/Testis Antigen 59² ³		Cytochrome C Oxidase Subunit VIb, Testes-Specific²
Cytochrome C Oxidase Subunit VIb, Testis-Specific Isoform² ³		Cytochrome C Oxidase Subunit VIb Isoform 2³
COX VIb-2² ³

External Ids:	HGNC: 24380¹	Entrez Gene: 125965²	Ensembl: ENSG00000160471⁷	UniProtKB: Q6YFQ2³

Export aliases for COX6B2 gene to outside databases

Previous GC identifers: GC19M060553 GC19M052183

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CX6B2_HUMAN, Q6YFQ2

Function: Connects the two COX monomers into the physiological dimeric form (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the COX6B2 gene promoter:
ER-alpha NF-1 Pax-5 AML1a NRSF form 1 NRSF form 2 PPAR-gamma1 STAT3 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: COX6B2 promoter sequence

Search SABiosciences Chromatin IP Primers for COX6B2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COX6B2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.42

COX6B2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COX6B2 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M055861: view genomic region (about GC identifiers)

Start:	55,860,674 bp from pter	End:	55,866,182 bp from pter
Size:	5,509 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CX6B2_HUMAN, Q6YFQ2 (See protein sequence)

Recommended Name: Cytochrome c oxidase subunit 6B2

Size: 88 amino acids; 10529 Da

Subcellular location: Mitochondrion intermembrane space (By similarity)

Secondary accessions: Q7L1R4 Q96DL5

Explore the universe of human proteins at neXtProt for COX6B2: NX_Q6YFQ2

COX6B2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_653214.2

ENSEMBL proteins:

ENSP00000467959 ENSP00000467266 ENSP00000320672 ENSP00000467128 ENSP00000465651

ENSP00000468759

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: COX6B2 OriGene Protein Over-expression Lysate: COX6B2 OriGene Custom Protein Services for COX6B2
	GenScript Custom Purified and Recombinant Proteins Services for COX6B2
	Novus Biologicals COX6B2 Proteins Novus Biologicals COX6B2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for COX6B2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	--	--
GO:0005758	mitochondrial intermembrane space	IEA	--
GO:0030061	mitochondrial crista	IDA	12874793

COX6B2 for ontologies About GeneDecksing

COX6B2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 2): COX6B2 OriGene Custom Antibody Services for COX6B2
	GenScript Custom Superior Antibodies Services for COX6B2
	Novus Biologicals COX6B2 Antibodies
	Abcam antibodies for COX6B2
	Uscn Antibodies for COX6B2
	ThermoFisher Antibodies for COX6B2

Assay Products for COX6B2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for COX6B2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for COX6B2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

COX6B2 for domains About GeneDecksing

1 InterPro domain/family:

IPR003213 Cyt_c_oxidase_su6B

Graphical View of Domain Structure for InterPro Entry Q6YFQ2

ProtoNet protein and cluster: Q6YFQ2

1 Blocks protein family: IPB003213 Cytochrome oxidase c

UniProtKB/Swiss-Prot: CX6B2_HUMAN, Q6YFQ2

Similarity: Belongs to the cytochrome c oxidase subunit 6B family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CX6B2_HUMAN, Q6YFQ2

Function: Connects the two COX monomers into the physiological dimeric form (By similarity)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COX6B2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate COX6B2
		SwitchGear 3'UTR luciferase reporter plasmid: COX6B2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COX6B2 (see all 7) OriGene shRNA RFP: COX6B2 OriGene siRNA: COX6B2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COX6B2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for COX6B2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COX6B2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COX6B2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: COX6B2 (NM_144613)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for COX6B2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX6B2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for COX6B2
		Search LifeMap BioReagents cell lines for COX6B2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX6B2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004129	cytochrome-c oxidase activity	IEA	--

COX6B2 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

	Oxidative phosphorylation	0.63			Alzheimer's disease	0.43
	Parkinson's disease	0.61			Huntington's disease	0.40

Cardiac muscle contraction

Cardiac muscle contraction

1.00

Metabolism

Metabolic pathways

0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 Kegg Pathways (Kegg details for COX6B2) (see all 6):

	Oxidative phosphorylation
	Metabolic pathways
	Cardiac muscle contraction
	Alzheimer's disease
	Parkinson's disease

COX6B2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for COX6B2

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

5/16 Interacting proteins for COX6B2 (ENSP00000320672⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 16)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MT-CO3	ENSP00000354982⁴	STRING: ENSP00000354982
MT-CO2	ENSP00000354876⁴	STRING: ENSP00000354876
COX5A	ENSP00000317780⁴	STRING: ENSP00000317780
MT-CO1	ENSP00000354499⁴	STRING: ENSP00000354499
COX5B	ENSP00000258424⁴	STRING: ENSP00000258424

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for COX6B2

2 HMDB Compounds for COX6B2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Oxygen	Oxygen (see all 5)	7782-44-7	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

Search CenterWatch for drugs/clinical trials and news about COX6B2 / CX6B2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for COX6B2 gene:

NM_144613.4

Unigene Cluster for COX6B2:

Cytochrome c oxidase subunit VIb polypeptide 2 (testis)

Hs.550544 [show with all ESTs]

Unigene Representative Sequence: AK057427

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000588572 ENST00000593184 ENST00000326529(uc002qkm.3 uc002qkn.3 uc002qko.3 uc002qkp.1)

ENST00000590900 ENST00000589879 ENST00000588586 ENST00000586191 ENST00000590549

ENST00000589467 ENST00000587357 ENST00000587854

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COX6B2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate COX6B2
		SwitchGear 3'UTR luciferase reporter plasmid: COX6B2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COX6B2 (see all 7) OriGene shRNA RFP: COX6B2 OriGene siRNA: COX6B2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COX6B2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COX6B2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COX6B2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: COX6B2 (NM_144613)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for COX6B2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX6B2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COX6B2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat COX6B2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COX6B2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COX6B2

Additional cDNA sequence:

AK057427.1 AY152398.1 BC100899.2 BC100900.1 BC100901.1 BC100902.1 HM370404.1

4 DOTS entries:

DT.101970804 DT.95258596 DT.75139246 DT.91856314

22 AceView cDNA sequences:

BC064548 BC026123 AA878062 AK057427 NM_144613 AL834316 AW194061 BC031875

BI827979 AK128284 BG324185 BM560283 AK127979 BG717038 BG716978 BG717157

AY152398 AW236235 AW087617 BG324108 BG722806 BE063485

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for COX6B2 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b
SP1:							-
SP2:							-						-		-		-		-
SP3:							-
SP4:							-
SP5:

ECgene alternative splicing isoforms for COX6B2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

COX6B2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAATATATA

About this image

COX6B2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Beating cell clusters (Spontaneous differen...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See COX6B2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COX6B2

SOURCE GeneReport for Unigene cluster: Hs.550544

UniProtKB/Swiss-Prot: CX6B2_HUMAN, Q6YFQ2

Tissue specificity: Testis specific. Weak expression in thymus and heart. Expressed in cancer cell lines

SABiosciences Expression via Pathway-Focused PCR Array including COX6B2:

Mitochondrial Energy Metabolism in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COX6B2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat COX6B2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COX6B2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COX6B2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX6B2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for COX6B2 gene from 7/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cox6b2^{1 , 5}	cytochrome c oxidase subunit VIb polypeptide 2^{1, 5}	82.95(n)¹ 80.68(a)¹		7 (2.75 cM)⁵ 333182¹ NM_183405.1¹ NP_899664.1¹ 4751794⁵
lizard (Anolis carolinensis)	Reptilia	COX6B1⁶	--	54(a)	1 ↔ 1	GL343279.1(1170051-1175530)
zebrafish (Danio rerio)	Actinopterygii	cox6b2⁶	cytochrome c oxidase subunit VIb polypeptide 2	56(a)	1 ↔ 1	16(14255661-14263011)
fruit fly (Drosophila melanogaster)	Insecta	CoVIb⁶	Cytochrome c oxidase subunit VIb	41(a)	1 → many	X(19634575-19638371)
worm (Caenorhabditis elegans)	Secernentea	Y71H2AM.5⁶	Protein Y71H2AM.5	24(a)	1 → many	III(2786109-2786851)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G28060⁶ AT5G57815⁶ (see all 3)	cytochrome c oxidase subunit VIb (see all 3)	38(a) 38(a) (see all 3)	many ↔ many many ↔ many (see all 3)	4(13943872-13945773) 5(23426668-23427856)
rice (Oryza sativa)	Liliopsida	-- cox6b⁶ (see all 3)	cytochrome c oxidase subunit, putative, expressed (see all 3)	47(a) 22(a) (see all 3)	many ↔ many many ↔ many (see all 3)	4(24721427-24724028) 3(15636488-15641183)

ENSEMBL Gene Tree for COX6B2 (if available)
TreeFam Gene Tree for COX6B2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for COX6B2 gene

COX6B1²

1 SIMAP similar gene for COX6B2 using alignment to 1 protein entry: CX6B2_HUMAN:

COX6B1

COX6B2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78995965^1,2	F,	--	55860593(+)	`TCCACT/AGCTAG`	1	--	int¹		1		EA	120
rs185590150^1,2		--	55860889(+)	`CAAGCC/GATCCT`	1	--	int¹		0	--	--	--	--
rs190441260^1,2		--	55860917(+)	`AAGTGC/GTAGGA`	1	--	int¹		0	--	--	--	--
rs146959385^1,2		--	55861006(+)	`GCAGCA/GGAGCA`	1	--	int¹		0	--	--	--	--
rs183306970^1,2		--	55861259(+)	`GGGAGC/GCTGAG`	1	--	ut3¹		0	--	--	--	--
rs187057939^1,2		--	55861279(+)	`TTGCCC/TGAGGT`	1	--	ut3¹		0	--	--	--	--
rs191810490^1,2		--	55861356(+)	`TGGGCA/GTGGTG`	1	--	ut3¹		0	--	--	--	--
rs184097500^1,2		--	55861359(+)	`GCGTGG/TTGGTG`	1	--	ut3¹		0	--	--	--	--
rs187577008^1,2		--	55861365(+)	`TGGTGC/TATGCC`	1	--	ut3¹		0	--	--	--	--
rs147585942^1,2		--	55861424(+)	`CGGGAC/GGCAGA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for COX6B2 (55860674 - 55866182 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for COX6B2
1 CNV: 30085

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COX6B2

DNA2.0 Custom Variant and Variant Library Synthesis for COX6B2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

COX6B2 for disorders About GeneDecksing

2 diseases for COX6B2: About MalaCards

huntington's disease parkinson's disease

Export disorders for COX6B2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for COX6B2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with COX6B2)

Utopia: connect your pdf to the dynamic
world of online information

Cytochrome c oxidase of mammals contains a testes-specific isoform of subunit VIb -- the counterpart to testes-specific cytochrome c? (PubMed id 12874793)^{1, 2, 3, 9} Huttemann M.... Grossman L.I. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Identification of cancer/testis-antigen genes by massively parallel signature sequencing. (PubMed id 15905330)² Chen Y.-T.... Simpson A.J.G. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Isolation of cDNAs encoding subunit VIb of cytochrome c oxidase and steady-state levels of coxVIb mRNA in different tissues. (PubMed id 2172092)¹ Taanman J.-W.... Agsteribbe E. (1990)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 125965	HGNC: 24380	AceView: COX6B2andMGC35045	Ensembl:ENSG00000160471	euGenes: HUgn125965
ECgene: COX6B2	Kegg: 125965	H-InvDB: COX6B2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for COX6B2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for COX6B2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for COX6B2 gene:
Search GeneIP for patents involving COX6B2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for COX6B2		OriGene shRNA RFP for COX6B2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COX6B2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COX6B2
	OriGene Protein Over-expression Lysate for COX6B2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for COX6B2		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COX6B2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COX6B2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for COX6B2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for COX6B2		OriGene Custom Protein Services for COX6B2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COX6B2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COX6B2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COX6B2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COX6B2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COX6B2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COX6B2

	GenScript Custom Purified and Recombinant Proteins Services for COX6B2		GenScript cDNA clones with any tag delivered in your preferred vector for COX6B2
	GenScript Custom Assay Services for COX6B2		GenScript Custom Superior Antibodies Services for COX6B2
	GenScript Custom overexpressing Cell Line Services for COX6B2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in COX6B2 promoter
	Search Chromatin IP Primers for COX6B2
	RT² qPCR Primer Assay in human, mouse, rat COX6B2
	Search GNC Networks for COX6B2
	SABiosciences PCR Arrays including human, mouse, rat COX6B2

Search Tocris compounds for COX6B2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	COX6B2 antibodies
	COX6B2 proteins
	COX6B2 lysates

	Antibodies for COX6B2
	See all of Abcam's Antibodies, Kits and Proteins for COX6B2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

COX6B2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for COX6B2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX6B2

	SwitchGear 3'UTR luciferase reporter plasmids for COX6B2
	SwitchGear Promoter luciferase reporter plasmids for COX6B2

ThermoFisher Antibodies for COX6B2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX6B2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes COX6B2 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

COX6B2 Gene

cytochrome c oxidase subunit VIb polypeptide 2 (testis)

Aliases
for COX6B2 gene

Summaries
for COX6B2 gene

Genomic Views
for COX6B2 gene

Proteins
for COX6B2 gene

Protein Domains /
Families
for COX6B2 gene

Function
for COX6B2 gene

Pathways & Interactions
for COX6B2 gene

Drugs & Compounds
for COX6B2 gene

Transcripts
for COX6B2 gene

Expression
for COX6B2 gene

Orthologs
for COX6B2 gene

Paralogs
for COX6B2 gene

Genomic Variants
for COX6B2 gene

Disorders / Diseases
for COX6B2 gene

Publications
for COX6B2 gene

External Searches for COX6B2 gene

Genome Databases showing COX6B2 gene

Other Databases showing COX6B2 gene

Specialized Databases showing COX6B2 gene

Intellectual Property
for COX6B2 gene

Products
for COX6B2 gene

View Random Gene

Advanced Search

Export list of displayed genes

COX6B2 Gene

cytochrome c oxidase subunit VIb polypeptide 2 (testis)

Aliasesfor COX6B2 gene

Summariesfor COX6B2 gene

Genomic Viewsfor COX6B2 gene

Proteinsfor COX6B2 gene

Protein Domains /Familiesfor COX6B2 gene

Functionfor COX6B2 gene

Pathways & Interactionsfor COX6B2 gene

Drugs & Compoundsfor COX6B2 gene

Transcriptsfor COX6B2 gene

Expression for COX6B2 gene

Orthologsfor COX6B2 gene

Paralogsfor COX6B2 gene

Genomic Variantsfor COX6B2 gene

Disorders / Diseasesfor COX6B2 gene

Publicationsfor COX6B2 gene

External Searches for COX6B2 gene

Genome Databases showing COX6B2 gene

Other Databases showing COX6B2 gene

Specialized Databases showing COX6B2 gene

Intellectual Propertyfor COX6B2 gene

Productsfor COX6B2 gene

View Random Gene

Aliases
for COX6B2 gene

Summaries
for COX6B2 gene

Genomic Views
for COX6B2 gene

Proteins
for COX6B2 gene

Protein Domains /
Families
for COX6B2 gene

Function
for COX6B2 gene

Pathways & Interactions
for COX6B2 gene

Drugs & Compounds
for COX6B2 gene

Transcripts
for COX6B2 gene

Expression
for COX6B2 gene

Orthologs
for COX6B2 gene

Paralogs
for COX6B2 gene

Genomic Variants
for COX6B2 gene

Disorders / Diseases
for COX6B2 gene

Publications
for COX6B2 gene

Intellectual Property
for COX6B2 gene

Products
for COX6B2 gene