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Aliases for COX6B2 Gene

Aliases for COX6B2 Gene

  • Cytochrome C Oxidase Subunit VIb Polypeptide 2 (Testis) 2 3
  • Cancer/Testis Antigen 59 2 3 4
  • COX VIb-2 3 4
  • CT59 3 4
  • Cytochrome C Oxidase Subunit VIb, Testis-Specific Isoform 4
  • Cytochrome C Oxidase Subunit VIb, Testes-Specific 3
  • Cytochrome C Oxidase Subunit VIb Isoform 2 4
  • Cytochrome C Oxidase Subunit VIb 2
  • Cytochrome C Oxidase Subunit 6B2 3
  • Testes Specific 2
  • COXVIB2 3

External Ids for COX6B2 Gene

Previous GeneCards Identifiers for COX6B2 Gene

  • GC19M060553
  • GC19M055861
  • GC19M052183

Summaries for COX6B2 Gene

GeneCards Summary for COX6B2 Gene

COX6B2 (Cytochrome C Oxidase Subunit VIb Polypeptide 2 (Testis)) is a Protein Coding gene. Among its related pathways are Metabolism and AMPK Enzyme Complex Pathway. GO annotations related to this gene include cytochrome-c oxidase activity. An important paralog of this gene is COX6B1.

UniProtKB/Swiss-Prot for COX6B2 Gene

  • Connects the two COX monomers into the physiological dimeric form.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX6B2 Gene

Genomics for COX6B2 Gene

Regulatory Elements for COX6B2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COX6B2 Gene

Start:
55,349,306 bp from pter
End:
55,354,814 bp from pter
Size:
5,509 bases
Orientation:
Minus strand

Genomic View for COX6B2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COX6B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX6B2 Gene

Proteins for COX6B2 Gene

  • Protein details for COX6B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6YFQ2-CX6B2_HUMAN
    Recommended name:
    Cytochrome c oxidase subunit 6B2
    Protein Accession:
    Q6YFQ2
    Secondary Accessions:
    • Q7L1R4
    • Q96DL5

    Protein attributes for COX6B2 Gene

    Size:
    88 amino acids
    Molecular mass:
    10529 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX6B2 Gene

Proteomics data for COX6B2 Gene at MOPED

Post-translational modifications for COX6B2 Gene

No Post-translational modifications

Other Protein References for COX6B2 Gene

No data available for DME Specific Peptides for COX6B2 Gene

Domains for COX6B2 Gene

Gene Families for COX6B2 Gene

HGNC:
  • comIV :Mitochondrial respiratory chain complex / Complex IV

Protein Domains for COX6B2 Gene

Suggested Antigen Peptide Sequences for COX6B2 Gene

Graphical View of Domain Structure for InterPro Entry

Q6YFQ2

UniProtKB/Swiss-Prot:

CX6B2_HUMAN :
  • Q6YFQ2
Family:
  • Belongs to the cytochrome c oxidase subunit 6B family.
genes like me logo Genes that share domains with COX6B2: view

Function for COX6B2 Gene

Molecular function for COX6B2 Gene

UniProtKB/Swiss-Prot Function: Connects the two COX monomers into the physiological dimeric form.

Gene Ontology (GO) - Molecular Function for COX6B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 cytochrome-c oxidase activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with COX6B2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COX6B2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for COX6B2 Gene

Localization for COX6B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX6B2 Gene

Mitochondrion intermembrane space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COX6B2 Gene COMPARTMENTS Subcellular localization image for COX6B2 gene
Compartment Confidence
mitochondrion 5
chloroplast 1
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for COX6B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005758 mitochondrial intermembrane space IEA --
GO:0030061 mitochondrial crista IDA 12874793
genes like me logo Genes that share ontologies with COX6B2: view

Pathways for COX6B2 Gene

genes like me logo Genes that share pathways with COX6B2: view

Pathways by source for COX6B2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Mitochondrial Energy Metabolism in human,mouse,rat

Gene Ontology (GO) - Biological Process for COX6B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1902600 hydrogen ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with COX6B2: view

Compounds for COX6B2 Gene

(2) HMDB Compounds for COX6B2 Gene

Compound Synonyms Cas Number PubMed IDs
Oxygen
  • Oxygen
7782-44-7
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with COX6B2: view

Transcripts for COX6B2 Gene

Unigene Clusters for COX6B2 Gene

Cytochrome c oxidase subunit VIb polypeptide 2 (testis):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COX6B2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for COX6B2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COX6B2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - - - - -
SP3: -
SP4: -
SP5:

Relevant External Links for COX6B2 Gene

GeneLoc Exon Structure for
COX6B2
ECgene alternative splicing isoforms for
COX6B2

Expression for COX6B2 Gene

mRNA expression in normal human tissues for COX6B2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COX6B2 Gene

This gene is overexpressed in Testis (37.7) and Colon - Transverse (4.6).

SOURCE GeneReport for Unigene cluster for COX6B2 Gene Hs.550544

mRNA Expression by UniProt/SwissProt for COX6B2 Gene

Q6YFQ2-CX6B2_HUMAN
Tissue specificity: Testis specific. Weak expression in thymus and heart. Expressed in cancer cell lines.
genes like me logo Genes that share expressions with COX6B2: view

In Situ Assay Products

No data available for Protein expression for COX6B2 Gene

Orthologs for COX6B2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for COX6B2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COX6B2 35
  • 99.62 (n)
  • 98.86 (a)
COX6B2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COX6B2 35
  • 87.88 (n)
  • 80.68 (a)
COX6B2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cox6b2 35
  • 82.95 (n)
  • 80.68 (a)
Cox6b2 16
Cox6b2 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cox6b2 35
  • 80.68 (n)
  • 75 (a)
zebrafish
(Danio rerio)
Actinopterygii cox6b2 36
  • 55 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CoVIb 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.5 36
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COX12 36
  • 40 (a)
OneToMany
Species with no ortholog for COX6B2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for COX6B2 Gene

ENSEMBL:
Gene Tree for COX6B2 (if available)
TreeFam:
Gene Tree for COX6B2 (if available)

Paralogs for COX6B2 Gene

Paralogs for COX6B2 Gene

Selected SIMAP similar genes for COX6B2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with COX6B2: view

Variants for COX6B2 Gene

Sequence variations from dbSNP and Humsavar for COX6B2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs921941 -- 55,351,043(+) CTGTC(C/T)GGTCA intron-variant
rs1466304 -- 55,353,035(+) GTTGG(A/G)AATAA intron-variant
rs4508529 -- 55,350,332(+) tccag(A/T)ccttg utr-variant-3-prime
rs7248925 -- 55,354,273(+) cgacc(A/C)ggccc intron-variant
rs10417356 -- 55,351,494(+) AGGCC(A/G)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COX6B2 Gene

Variant ID Type Subtype PubMed ID
dgv4016n71 CNV Loss 21882294
nsv912457 CNV Loss 21882294
nsv912460 CNV Loss 21882294
nsv912461 CNV Loss 21882294
nsv470162 CNV Loss 18288195
dgv4017n71 CNV Loss 21882294
nsv912463 CNV Loss 21882294
nsv516199 CNV Loss 19592680

Relevant External Links for COX6B2 Gene

HapMap Linkage Disequilibrium report
COX6B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX6B2 Gene

Disorders for COX6B2 Gene

No disorders were found for COX6B2 Gene.

No data available for UniProtKB/Swiss-Prot for COX6B2 Gene

Publications for COX6B2 Gene

  1. Cytochrome c oxidase of mammals contains a testes-specific isoform of subunit VIb -- the counterpart to testes-specific cytochrome c? (PMID: 12874793) Huttemann M. … Grossman L.I. (Mol. Reprod. Dev. 2003) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PMID: 18854154) KAPnig R. … Chanda S.K. (Cell 2008) 3

Products for COX6B2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Mitochondrial Energy Metabolism in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate COX6B2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for COX6B2
    • Block miRNA regulation of COX6B2 using miScript Target Protectors
    • antibodies-online proteins for COX6B2
    • antibodies-online antibodies for COX6B2
    • antibodies-online kits for COX6B2

    Sources for COX6B2 Gene

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