Free for academic non-profit institutions. Other users need a Commercial license

Aliases for COX6B2 Gene

Aliases for COX6B2 Gene

  • Cytochrome C Oxidase Subunit 6B2 2 3 5
  • Cancer/Testis Antigen 59 2 3 4
  • Cytochrome C Oxidase Subunit VIb Polypeptide 2 (Testis) 2 3
  • COX VIb-2 3 4
  • CT59 3 4
  • Cytochrome C Oxidase Subunit VIb, Testis-Specific Isoform 4
  • Cytochrome C Oxidase Subunit VIb, Testes Specific 2
  • Cytochrome C Oxidase Subunit VIb, Testes-Specific 3
  • Cytochrome C Oxidase Subunit VIb Isoform 2 4
  • COXVIB2 3

External Ids for COX6B2 Gene

Previous GeneCards Identifiers for COX6B2 Gene

  • GC19M060553
  • GC19M055861
  • GC19M052183

Summaries for COX6B2 Gene

GeneCards Summary for COX6B2 Gene

COX6B2 (Cytochrome C Oxidase Subunit 6B2) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Cardiac muscle contraction. GO annotations related to this gene include cytochrome-c oxidase activity. An important paralog of this gene is COX6B1.

UniProtKB/Swiss-Prot for COX6B2 Gene

  • Connects the two COX monomers into the physiological dimeric form.

Additional gene information for COX6B2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX6B2 Gene

Genomics for COX6B2 Gene

Regulatory Elements for COX6B2 Gene

Enhancers for COX6B2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H055382 1.4 ENCODE dbSUPER 11.6 -32.1 -32050 8.2 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 PAF1 SP3 RPL28 ZNF628 ENSG00000267689 RFPL4AP1 RPL13P13 LENG8-AS1 ZNF581 U2AF2 COX6B2 ENSG00000269275
GH19H055353 0.8 ENCODE 13 +0.8 799 1.2 MXI1 KLF1 ZNF777 RB1 SAP130 HIC1 GLIS2 POLR2A PATZ1 ZNF600 COX6B2 PIR31434 PIR52348
GH19H055368 1.3 FANTOM5 ENCODE 4.2 -15.2 -15177 2.9 PKNOX1 ZNF76 KLF17 SIN3A GLI4 ZNF121 GLIS2 EGR1 ZNF366 SCRT2 TMEM190 RPL28 COX6B2 IL11 NAT14 ZNF579 FAM71E2
GH19H055405 1.4 FANTOM5 ENCODE 1.4 -52.6 -52612 3.7 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 ZNF416 U2AF2 LENG8 ZNF628 LENG8-AS1 RPL28 ENSG00000267523 EDDM13 ZNF581 ENSG00000235681 ENSG00000267838
GH19H055447 1.1 FANTOM5 dbSUPER 1.4 -92.8 -92757 0.4 ATF1 ZNF140 SIN3A ZIC2 HIC1 ZNF121 GLIS2 POLR2A PATZ1 ADNP U2AF2 LENG8-AS1 LENG8 ENSG00000267523 CDC42EP5 SSC5D ZNF580 KMT5C ENSG00000279794 ZNF581
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around COX6B2 on UCSC Golden Path with GeneCards custom track

Promoters for COX6B2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111638 714 601 MXI1 KLF1 ZNF777 RB1 SAP130 POLR2A PATZ1 ZNF600 KLF8 EZH2

Genomic Locations for COX6B2 Gene

Genomic Locations for COX6B2 Gene
chr19:55,349,306-55,354,814
(GRCh38/hg38)
Size:
5,509 bases
Orientation:
Minus strand
chr19:55,860,674-55,866,182
(GRCh37/hg19)

Genomic View for COX6B2 Gene

Genes around COX6B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX6B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX6B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX6B2 Gene

Proteins for COX6B2 Gene

  • Protein details for COX6B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6YFQ2-CX6B2_HUMAN
    Recommended name:
    Cytochrome c oxidase subunit 6B2
    Protein Accession:
    Q6YFQ2
    Secondary Accessions:
    • Q7L1R4
    • Q96DL5

    Protein attributes for COX6B2 Gene

    Size:
    88 amino acids
    Molecular mass:
    10529 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX6B2 Gene

Post-translational modifications for COX6B2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COX6B2 Gene

No data available for DME Specific Peptides for COX6B2 Gene

Domains & Families for COX6B2 Gene

Gene Families for COX6B2 Gene

Protein Domains for COX6B2 Gene

Suggested Antigen Peptide Sequences for COX6B2 Gene

Graphical View of Domain Structure for InterPro Entry

Q6YFQ2

UniProtKB/Swiss-Prot:

CX6B2_HUMAN :
  • Belongs to the cytochrome c oxidase subunit 6B family.
Family:
  • Belongs to the cytochrome c oxidase subunit 6B family.
genes like me logo Genes that share domains with COX6B2: view

Function for COX6B2 Gene

Molecular function for COX6B2 Gene

UniProtKB/Swiss-Prot Function:
Connects the two COX monomers into the physiological dimeric form.

Gene Ontology (GO) - Molecular Function for COX6B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with COX6B2: view
genes like me logo Genes that share phenotypes with COX6B2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for COX6B2 Gene

Localization for COX6B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX6B2 Gene

Mitochondrion intermembrane space.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COX6B2 gene
Compartment Confidence
mitochondrion 5
plasma membrane 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for COX6B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005758 mitochondrial intermembrane space IEA --
GO:0030061 mitochondrial crista IDA 12874793
genes like me logo Genes that share ontologies with COX6B2: view

Pathways & Interactions for COX6B2 Gene

genes like me logo Genes that share pathways with COX6B2: view

Pathways by source for COX6B2 Gene

Gene Ontology (GO) - Biological Process for COX6B2 Gene

None

No data available for SIGNOR curated interactions for COX6B2 Gene

Drugs & Compounds for COX6B2 Gene

(2) Drugs for COX6B2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with COX6B2: view

Transcripts for COX6B2 Gene

Unigene Clusters for COX6B2 Gene

Cytochrome c oxidase subunit VIb polypeptide 2 (testis):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for COX6B2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - - - - -
SP3: -
SP4: -
SP5:

Relevant External Links for COX6B2 Gene

GeneLoc Exon Structure for
COX6B2
ECgene alternative splicing isoforms for
COX6B2

Expression for COX6B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COX6B2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COX6B2 Gene

This gene is overexpressed in Testis (x37.7) and Colon - Transverse (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of COX6B2 Gene:

COX6B2

SOURCE GeneReport for Unigene cluster for COX6B2 Gene:

Hs.550544

mRNA Expression by UniProt/SwissProt for COX6B2 Gene:

Q6YFQ2-CX6B2_HUMAN
Tissue specificity: Testis specific. Weak expression in thymus and heart. Expressed in cancer cell lines.
genes like me logo Genes that share expression patterns with COX6B2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for COX6B2 Gene

Orthologs for COX6B2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for COX6B2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COX6B2 33 34
  • 99.62 (n)
cow
(Bos Taurus)
Mammalia COX6B2 33 34
  • 87.88 (n)
mouse
(Mus musculus)
Mammalia Cox6b2 33 16 34
  • 82.95 (n)
rat
(Rattus norvegicus)
Mammalia Cox6b2 33
  • 80.68 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 67 (a)
OneToMany
-- 34
  • 60 (a)
OneToMany
-- 34
  • 60 (a)
OneToMany
-- 34
  • 56 (a)
OneToMany
-- 34
  • 56 (a)
OneToMany
-- 34
  • 55 (a)
OneToMany
-- 34
  • 49 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii cox6b2 34
  • 55 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CoVIb 34
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.5 34
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COX12 34
  • 40 (a)
OneToMany
Species where no ortholog for COX6B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for COX6B2 Gene

ENSEMBL:
Gene Tree for COX6B2 (if available)
TreeFam:
Gene Tree for COX6B2 (if available)

Paralogs for COX6B2 Gene

Paralogs for COX6B2 Gene

(1) SIMAP similar genes for COX6B2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with COX6B2: view

Variants for COX6B2 Gene

Sequence variations from dbSNP and Humsavar for COX6B2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000147287 -- 55,353,753(+) CTTGA(G/T)CTGCT reference, missense
rs1000483841 -- 55,352,568(+) TAGGA(A/C)CGCTT intron-variant
rs1001809020 -- 55,353,347(+) GAACT(A/G)GGGAC intron-variant
rs1001923007 -- 55,353,521(+) TTAGC(C/T)CGGAC intron-variant
rs1002312740 -- 55,352,655(+) ACCAG(C/T)ACCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COX6B2 Gene

Variant ID Type Subtype PubMed ID
nsv953624 CNV deletion 24416366
nsv516199 CNV loss 19592680
nsv470162 CNV loss 18288195
nsv1071551 CNV deletion 25765185

Variation tolerance for COX6B2 Gene

Residual Variation Intolerance Score: 67.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COX6B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COX6B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX6B2 Gene

Disorders for COX6B2 Gene

Relevant External Links for COX6B2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COX6B2

No disorders were found for COX6B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX6B2 Gene

Publications for COX6B2 Gene

  1. Cytochrome c oxidase of mammals contains a testes-specific isoform of subunit VIb--the counterpart to testes-specific cytochrome c? (PMID: 12874793) Hüttemann M … Grossman LI (Molecular reproduction and development 2003) 2 3 4 22 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 60
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60

Products for COX6B2 Gene

Sources for COX6B2 Gene

Content
Loading form....