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Aliases for COX6B2 Gene

Aliases for COX6B2 Gene

  • Cytochrome C Oxidase Subunit 6B2 2 3
  • Cytochrome C Oxidase Subunit VIb Polypeptide 2 (Testis) 2 3 5
  • Cancer/Testis Antigen 59 2 3 4
  • COX VIb-2 3 4
  • CT59 3 4
  • Cytochrome C Oxidase Subunit VIb, Testis-Specific Isoform 4
  • Cytochrome C Oxidase Subunit VIb, Testes-Specific 3
  • Cytochrome C Oxidase Subunit VIb Isoform 2 4
  • Cytochrome C Oxidase Subunit VIb 2
  • Testes Specific 2
  • COXVIB2 3

External Ids for COX6B2 Gene

Previous GeneCards Identifiers for COX6B2 Gene

  • GC19M060553
  • GC19M055861
  • GC19M052183

Summaries for COX6B2 Gene

GeneCards Summary for COX6B2 Gene

COX6B2 (Cytochrome C Oxidase Subunit 6B2) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include cytochrome-c oxidase activity. An important paralog of this gene is COX6B1.

UniProtKB/Swiss-Prot for COX6B2 Gene

  • Connects the two COX monomers into the physiological dimeric form.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX6B2 Gene

Genomics for COX6B2 Gene

Regulatory Elements for COX6B2 Gene

Enhancers for COX6B2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around COX6B2 on UCSC Golden Path with GeneCards custom track

Promoters for COX6B2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COX6B2 on UCSC Golden Path with GeneCards custom track

Genomic Location for COX6B2 Gene

55,349,306 bp from pter
55,354,814 bp from pter
5,509 bases
Minus strand

Genomic View for COX6B2 Gene

Genes around COX6B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX6B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX6B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX6B2 Gene

Proteins for COX6B2 Gene

  • Protein details for COX6B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome c oxidase subunit 6B2
    Protein Accession:
    Secondary Accessions:
    • Q7L1R4
    • Q96DL5

    Protein attributes for COX6B2 Gene

    88 amino acids
    Molecular mass:
    10529 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX6B2 Gene

Proteomics data for COX6B2 Gene at MOPED

Post-translational modifications for COX6B2 Gene

No Post-translational modifications

Other Protein References for COX6B2 Gene

No data available for DME Specific Peptides for COX6B2 Gene

Domains & Families for COX6B2 Gene

Protein Domains for COX6B2 Gene

Suggested Antigen Peptide Sequences for COX6B2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome c oxidase subunit 6B family.
  • Belongs to the cytochrome c oxidase subunit 6B family.
genes like me logo Genes that share domains with COX6B2: view

Function for COX6B2 Gene

Molecular function for COX6B2 Gene

UniProtKB/Swiss-Prot Function:
Connects the two COX monomers into the physiological dimeric form.
genes like me logo Genes that share phenotypes with COX6B2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for COX6B2 Gene

Localization for COX6B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX6B2 Gene

Mitochondrion intermembrane space.

Subcellular locations from

Jensen Localization Image for COX6B2 Gene COMPARTMENTS Subcellular localization image for COX6B2 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for COX6B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005758 mitochondrial intermembrane space IEA --
genes like me logo Genes that share ontologies with COX6B2: view

Pathways & Interactions for COX6B2 Gene

genes like me logo Genes that share pathways with COX6B2: view

Pathways by source for COX6B2 Gene

Gene Ontology (GO) - Biological Process for COX6B2 Gene


No data available for SIGNOR curated interactions for COX6B2 Gene

Drugs & Compounds for COX6B2 Gene

(2) Additional Compounds for COX6B2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with COX6B2: view

Transcripts for COX6B2 Gene

Unigene Clusters for COX6B2 Gene

Cytochrome c oxidase subunit VIb polypeptide 2 (testis):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COX6B2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - - - - -
SP3: -
SP4: -

Relevant External Links for COX6B2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COX6B2 Gene

mRNA expression in normal human tissues for COX6B2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COX6B2 Gene

This gene is overexpressed in Testis (x37.7) and Colon - Transverse (x4.6).

SOURCE GeneReport for Unigene cluster for COX6B2 Gene Hs.550544

mRNA Expression by UniProt/SwissProt for COX6B2 Gene

Tissue specificity: Testis specific. Weak expression in thymus and heart. Expressed in cancer cell lines.
genes like me logo Genes that share expression patterns with COX6B2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for COX6B2 Gene

Orthologs for COX6B2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for COX6B2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia COX6B2 35
  • 87.88 (n)
  • 80.68 (a)
COX6B2 36
  • 81 (a)
(Mus musculus)
Mammalia Cox6b2 35
  • 82.95 (n)
  • 80.68 (a)
Cox6b2 16
Cox6b2 36
  • 81 (a)
(Pan troglodytes)
Mammalia COX6B2 35
  • 99.62 (n)
  • 98.86 (a)
COX6B2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cox6b2 35
  • 80.68 (n)
  • 75 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
-- 36
  • 55 (a)
-- 36
  • 49 (a)
-- 36
  • 56 (a)
-- 36
  • 56 (a)
-- 36
  • 60 (a)
-- 36
  • 67 (a)
(Danio rerio)
Actinopterygii cox6b2 36
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CoVIb 36
  • 39 (a)
(Caenorhabditis elegans)
Secernentea Y71H2AM.5 36
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COX12 36
  • 40 (a)
Species with no ortholog for COX6B2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for COX6B2 Gene

Gene Tree for COX6B2 (if available)
Gene Tree for COX6B2 (if available)

Paralogs for COX6B2 Gene

Paralogs for COX6B2 Gene

(1) SIMAP similar genes for COX6B2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with COX6B2: view

Variants for COX6B2 Gene

Sequence variations from dbSNP and Humsavar for COX6B2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs921941 -- 55,351,043(+) CTGTC(C/T)GGTCA intron-variant
rs1466304 -- 55,353,035(+) GTTGG(A/G)AATAA intron-variant
rs33929957 -- 55,349,305(+) TTTTT(-/T)GAGAC downstream-variant-500B
rs73607032 -- 55,350,773(+) AGCAA(A/G)GGAAA utr-variant-3-prime
rs73607033 -- 55,351,372(+) TGCCA(C/G)CTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COX6B2 Gene

Variant ID Type Subtype PubMed ID
dgv4016n71 CNV Loss 21882294
nsv912457 CNV Loss 21882294
nsv912460 CNV Loss 21882294
nsv912461 CNV Loss 21882294
nsv470162 CNV Loss 18288195
dgv4017n71 CNV Loss 21882294
nsv912463 CNV Loss 21882294
nsv516199 CNV Loss 19592680

Variation tolerance for COX6B2 Gene

Residual Variation Intolerance Score: 67.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.90% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for COX6B2 Gene

Disorders for COX6B2 Gene

Relevant External Links for COX6B2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for COX6B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX6B2 Gene

Publications for COX6B2 Gene

  1. Cytochrome c oxidase of mammals contains a testes-specific isoform of subunit VIb -- the counterpart to testes-specific cytochrome c? (PMID: 12874793) Huttemann M. … Grossman L.I. (Mol. Reprod. Dev. 2003) 2 3 4 23 67
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PMID: 18854154) KAPnig R. … Chanda S.K. (Cell 2008) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for COX6B2 Gene

Sources for COX6B2 Gene