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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COX6B1 Gene

protein-coding   GIFtS: 61
GCID: GC19P036140

Cytochrome C Oxidase Subunit VIb Polypeptide 1 (Ubiquitous)

(Previous names: cytochrome c oxidase subunit Vib, cytochrome c oxidase subunit...)
(Previous symbol: COX6B)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cytochrome C Oxidase Subunit VIb Polypeptide 1 (Ubiquitous)1 2     COXG2
COX6B1 2 3     COXVIb12
COX VIb-12 3     Cytochrome C Oxidase Subunit 6B12
Cytochrome C Oxidase Subunit Vib1     Cytochrome C Oxidase Subunit VIb Isoform 13

External Ids:    HGNC: 22801   Entrez Gene: 13402   Ensembl: ENSG000001262677   OMIM: 1240895   UniProtKB: P148543   

Export aliases for COX6B1 gene to outside databases

Previous GC identifers: GC19P040831 GC19P032644


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COX6B1 Gene:
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron
transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits
encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The
mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved
in the regulation and assembly of the complex. This nuclear gene encodes subunit VIb. Mutations in this gene are
associated with severe infantile encephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 and COX6BP-3 have been
found on chromosomes 7, 17 and 22q13.1-13.2, respectively. (provided by RefSeq, Jan 2010)

GeneCards Summary for COX6B1 Gene: 
COX6B1 (cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)) is a protein-coding gene. Diseases associated with COX6B1 include encephalomyopathy, and hypotonia, and among its related super-pathways are Electron Transport Chain and Metabolic pathways. GO annotations related to this gene include cytochrome-c oxidase activity. An important paralog of this gene is COX6B2.

UniProtKB/Swiss-Prot: CX6B1_HUMAN, P14854
Function: Connects the two COX monomers into the physiological dimeric form (By similarity)

Gene Wiki entry for COX6B1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COX6B1 gene promoter:
         E2F-4   E2F-3a   E2F-5   HTF   RelA   E2F-2   GATA-2   c-Ets-1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOX6B1 promoter sequence
   Search SABiosciences Chromatin IP Primers for COX6B1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COX6B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.1

COX6B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COX6B1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P036140:  view genomic region     (about GC identifiers)

Start:
36,139,125 bp from pter      End:
36,149,763 bp from pter
Size:
10,639 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CX6B1_HUMAN, P14854 (See protein sequence)
Recommended Name: Cytochrome c oxidase subunit 6B1  
Size: 86 amino acids; 10192 Da
Subcellular location: Mitochondrion intermembrane space (By similarity)
Secondary accessions: B2R5C9 Q6IBL4

Explore the universe of human proteins at neXtProt for COX6B1: NX_P14854

Explore proteomics data for COX6B1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P14854

  • COX6B1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    COX6B1 Protein Expression
    REFSEQ proteins: NP_001854.1  
    ENSEMBL proteins: 
     ENSP00000246554   ENSP00000466818   ENSP00000376037   ENSP00000467776  
    Reactome Protein details: P14854
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    Novus Biologicals COX6B1 Proteins
    Novus Biologicals COX6B1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005758mitochondrial intermembrane space IEA--

    COX6B1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    comIV: Mitochondrial respiratory chain complex / Complex IV

    1 InterPro protein domain:
     IPR003213 Cyt_c_oxidase_su6B

    Graphical View of Domain Structure for InterPro Entry P14854

    ProtoNet protein and cluster: P14854

    1 Blocks protein domain: IPB003213 Cytochrome oxidase c

    UniProtKB/Swiss-Prot: CX6B1_HUMAN, P14854
    Similarity: Belongs to the cytochrome c oxidase subunit 6B family


    COX6B1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CX6B1_HUMAN, P14854
    Function: Connects the two COX monomers into the physiological dimeric form (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004129cytochrome-c oxidase activity NAS2172092
         
    COX6B1 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for COX6B1 About                                                                                                See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Parkinson's disease0.61
    Respiratory electron transport0.81
    Huntington's disease0.47
    Electron Transport Chain0.75
    Alzheimer's disease0.46
    The citric acid (TCA) cycle and respiratory electron transport0.72
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    3Cardiac muscle contraction
    Cardiac muscle contraction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for COX6B1
        Electron Transport Chain

    4        Reactome Pathways for COX6B1
        Respiratory electron transport
    Metabolism
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport


    5/7         Kegg Pathways  (Kegg details for COX6B1) (see all 7):
        Oxidative phosphorylation
    Metabolic pathways
    Cardiac muscle contraction
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease


    COX6B1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COX6B1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/30 Interacting proteins for COX6B1 (P148543 ENSP000002465544) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MT-CO2P004033, ENSP000003548764I2D: score=1 STRING: ENSP00000354876
    NELFCDQ8IXH73, ENSP000003423004I2D: score=1 STRING: ENSP00000342300
    COX4I1ENSP000002534524STRING: ENSP00000253452
    COX7A2LENSP000002343014STRING: ENSP00000234301
    COX7CENSP000002476554STRING: ENSP00000247655
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0022904respiratory electron transport chain TAS--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0055114oxidation-reduction process NAS--

    COX6B1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for COX6B1 (CX6B1)

    2 HMDB Compounds for COX6B1    About this table
    CompoundSynonyms CAS #PubMed Ids
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for COX6B1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cholic Acid-- 81-25-4target--10592235
    N-Formylmethionine-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about COX6B1 / CX6B1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for COX6B1 gene: 
    NM_001863.4  

    Unigene Cluster for COX6B1:

    Cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
    Hs.431668  [show with all ESTs]
    Unigene Representative Sequence: CD517959
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000246554(uc002oav.3) ENST00000592141 ENST00000392201 ENST00000590618


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    Additional mRNA sequence: 

    AK312140.1 BC001015.2 BC002478.2 BT006945.1 CR456789.1 CR542137.1 X13923.1 X54473.1 

    17 DOTS entries:

    DT.100693282  DT.87018180  DT.100826502  DT.100826505  DT.121410468  DT.121410479  DT.100044739  DT.99986089 
    DT.100826506  DT.91769100  DT.95259097  DT.121410464  DT.121410465  DT.92373372  DT.95312469  DT.121124434 
    DT.121124435 

    24/551 AceView cDNA sequences (see all 551):

    BG574973 BE019228 BC001015 AA129394 AI567551 AI167254 N99907 W76623 
    AA758037 BG165187 AA010401 CR542137 F21747 F24275 BQ684825 AI718857 
    CB148431 AA708283 AA167700 BM692564 F30457 AA047030 AI569750 BF033429 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for COX6B1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
    SP1:                              
    SP2:                    -         


    ECgene alternative splicing isoforms for COX6B1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COX6B1 expression in normal human tissues (normalized intensities)      COX6B1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTTACCTGC
    COX6B1 Expression
    About this image


    COX6B1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             ganglion/cranial   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             heart/ventricle   
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Thyroid (Endocrine System)
             parathyroid gland   
     
     Blood (Cardiovascular System)
             mouse/organ system/cardiovascular system   

    See COX6B1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COX6B1

    SOURCE GeneReport for Unigene cluster: Hs.431668
        SABiosciences Expression via Pathway-Focused PCR Arrays including COX6B1: 
              Mitochondrial Energy Metabolism in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX6B1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COX6B1 gene from 8/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cox6b11 , 5 cytochrome c oxidase, subunit VIb polypeptide 11, 5 85.66(n)1
    84.88(a)1
      7 (18.84 cM)5
    1103231  NM_025628.21  NP_079904.11 
     306169745 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.347242 Xenopus laevis transcribed sequence with weak similarity more 69.9(n)    BJ637694.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa92g052 Transcribed sequence with moderate similarity to protein more 73(n)    BI671464.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG142351 CG14235 64.79(n)
    61.97(a)
      32989  NM_167678.2  NP_728294.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y71H2AM.56
    Protein Y71H2AM.5
    26(a)
    1 → many
    III(2786117-2786859)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes COX12(YLR038C)4
    COX121
    Subunit VIb of cytochrome c oxidase, which is the terminal more4
    Cox12p1
    53.81(n)1
    48.57(a)1
      12(225172-224921)4
    8507271, 4  NP_013139.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons COX6B1 cytochrome C oxidase 6B 53.25(n)
    50(a)
      838851  NM_102094.3  NP_173661.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g03904001 hypothetical protein 52.99(n)
    52.56(a)
      4333018  NM_001056810.1  NP_001050275.1 


    ENSEMBL Gene Tree for COX6B1 (if available)
    TreeFam Gene Tree for COX6B1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for COX6B1 gene
    COX6B22  
    1 SIMAP similar gene for COX6B1 using alignment to 2 protein entries:     CX6B1_HUMAN (see all proteins):
    COX6B2

    COX6B1 for paralogs           About GeneDecksing


    5/7 Pseudogenes.org Pseudogenes for COX6B1 (see all 7)
    PGOHUM00000237426 PGOHUM00000244751 PGOHUM00000246592 PGOHUM00000245807 PGOHUM00000233640


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/298 SNPs in COX6B1 are shown (see all 298)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0467754
    Mitochondrial complex IV deficiency (MT-C4D)4--see VAR_0467752 R H mis40--------
    rs114268031,2
    C--36141611(+) AAAAA-/ACATTC 1 -- int1 trp30--------
    rs602188801,2
    C--36146661(+) TCTCT-/CTCT  
      CTCTCT
    TTGTC
    1 -- int10--------
    rs2017355541,2
    C--36296134(+) AGCCT-/CCCAAA 1 -- us2k10--------
    rs1379188971,2
    --36296149(+) TGGGAA/TTACAG 1 -- us2k10--------
    rs1424692521,2
    --36296308(+) TGCCTA/GGCCCC 1 -- us2k10--------
    rs1457483181,2
    --36296424(+) GTTGAC/TGGACA 1 -- us2k10--------
    rs1906019261,2
    --36296697(+) TGATAA/TTTCTT 1 -- us2k10--------
    rs1382994051,2
    --36296757(+) ATAGCC/TGGGCA 1 -- us2k10--------
    rs1496386481,2
    C--36296991(+) GATCAC/TACCAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for COX6B1 (36139125 - 36149763 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for COX6B1: --

    Human Gene Mutation Database (HGMD): COX6B1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing COX6B1
    DNA2.0 Custom Variant and Variant Library Synthesis for COX6B1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 124089   
    OMIM disorders: 220110  
    UniProtKB/Swiss-Prot: CX6B1_HUMAN, P14854
  • Mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]: A disorder of the mitochondrial respiratory
    chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease
    affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver
    dysfunction, hypotonia, muscle weakness, exercise intolerance, developmental delay, delayed motor development and
    mental retardation. Some affected individuals manifest a fatal hypertrophic cardiomyopathy resulting in neonatal
    death. A subset of patients manifest Leigh syndrome. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 9 diseases for COX6B1:    About MalaCards
    encephalomyopathy    hypotonia    hypertrophic cardiomyopathy    huntington's disease
    parkinson's disease    myopathy    mental retardation    alzheimer's disease
    breast cancer


    COX6B1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): COX6B1
    Human Genome Epidemiology (HuGE) Navigator: COX6B1 (1 document)

    Export disorders for COX6B1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COX6B1 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with COX6B1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nucleotide sequence of the last exon of the gene for human cytochrome c oxidase subunit VIb and its flanking regions. (PubMed id 1647217)1, 2, 9 Taanman J.-W....de Vries H. (1991)
    2. Human cytochrome c oxidase subunit VIb: characterization and mapping of a multigene family. (PubMed id 1651883)1, 2, 9 Carrero-Valenzuela R.D.... Forte M.A. (1991)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. Severe infantile encephalomyopathy caused by a mutation in COX6B1, a nucleus-encoded subunit of cytochrome c oxidase. (PubMed id 18499082)1, 2 Massa V....Zeviani M. (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    7. Assignment of the gene coding for human cytochrome c oxidase subunit VIb to chromosome 19, band q13.1, by fluorescence in situ hybridisation. (PubMed id 1650756)1, 3 Taanman J.W....Buys C.H. (1991)
    8. Isolation of cDNAs encoding subunit VIb of cytochrome c oxidase and steady-state levels of coxVIb mRNA in different tissues. (PubMed id 2172092)1, 2 Taanman J.-W.... Agsteribbe E. (1990)
    9. Nucleotide sequence of cDNA encoding subunit VIb of human cytochrome c oxidase. (PubMed id 2537962)1, 2 Taanman J.-W....Agsteribbe E. (1989)
    10. HIV-1 Tat protein directly induces mitochondrial membr ane permeabilization and inactivates cytochrome c oxidase. (PubMed id 22419111)1 Lecoeur H....Jacotot E. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1340 HGNC: 2280 AceView: COX6B1 Ensembl:ENSG00000126267 euGenes: HUgn1340
    ECgene: COX6B1 Kegg: 1340 H-InvDB: COX6B1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COX6B1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for COX6B1 gene:
    Search GeneIP for patents involving COX6B1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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