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COX6A2 Gene

protein-coding   GIFtS: 56
GCID: GC16M031439

Cytochrome C Oxidase Subunit VIa Polypeptide 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cytochrome C Oxidase Subunit VIa Polypeptide 21 2     COXVIAH2 3
Cytochrome C Oxidase Polypeptide VIa-Heart2 3     COX VIa-M2 3
Cytochrome C Oxidase Subunit VIA-Muscle2 3     Cytochrome C Oxidase Subunit 6A2, Mitochondrial2
COX6AH2 3     COX6A3

External Ids:    HGNC: 22791   Entrez Gene: 13392   Ensembl: ENSG000001568857   OMIM: 6020095   UniProtKB: Q022213   
ORGUL members:         

Export aliases for COX6A2 gene to outside databases

Previous GC identifers: GC16U990015 GC16M031935 GC16M031435 GC16M031475 GC16M031346 GC16M028999


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COX6A2 Gene:
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron
transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits
encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The
mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved
in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (heart/muscle isoform) of
subunit VIa, and polypeptide 2 is present only in striated muscles. Polypeptide 1 (liver isoform) of subunit VIa
is encoded by a different gene, and is found in all non-muscle tissues. These two polypeptides share 66% amino
acid sequence identity. (provided by RefSeq, Jul 2008)

GeneCards Summary for COX6A2 Gene:
COX6A2 (cytochrome c oxidase subunit VIa polypeptide 2) is a protein-coding gene. GO annotations related to this gene include cytochrome-c oxidase activity. An important paralog of this gene is COX6A1.

UniProtKB/Swiss-Prot: CX6A2_HUMAN, Q02221
Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal
oxidase in mitochondrial electron transport




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the COX6A2 gene promoter:
         Elk-1   AML1a   GCNF   GATA-1   RORalpha1   Egr-2   AREB6   GCNF-1   GCNF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOX6A2 promoter sequence
   Search Chromatin IP Primers for COX6A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COX6A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.12   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.12

COX6A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COX6A2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M031439:  view genomic region     (about GC identifiers)

Start:
31,439,052 bp from pter      End:
31,439,967 bp from pter
Size:
916 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CX6A2_HUMAN, Q02221 (See protein sequence)
Recommended Name: Cytochrome c oxidase subunit 6A2, mitochondrial precursor  
Size: 97 amino acids; 10815 Da
Secondary accessions: O00761 Q6GTW6

Explore the universe of human proteins at neXtProt for COX6A2: NX_Q02221

Explore proteomics data for COX6A2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys70
  • Modification sites at PhosphoSitePlus

  • See COX6A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005196.1  
    ENSEMBL proteins: 
     ENSP00000287490  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    comIV: Mitochondrial respiratory chain complex / Complex IV

    2 InterPro protein domains:
     IPR018507 Cyt_c_oxidase_su6a_CS
     IPR001349 Cyt_c_oxidase_su6a

    Graphical View of Domain Structure for InterPro Entry Q02221

    ProtoNet protein and cluster: Q02221

    1 Blocks protein domain: IPB001349 Cytochrome c oxidase

    UniProtKB/Swiss-Prot: CX6A2_HUMAN, Q02221
    Similarity: Belongs to the cytochrome c oxidase subunit 6A family


    Find genes that share domains with COX6A2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CX6A2_HUMAN, Q02221
    Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal
    oxidase in mitochondrial electron transport

         Genatlas biochemistry entry for COX6A2:
    cytochrome c oxidase,subunit VIa2,component of the complex IV,terminal enzyme complex for electron
    transfert,oxidative phosphorylation (OXPHOS),inner mitochondrial membrane

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004129cytochrome-c oxidase activity IEA--
         
    Find genes that share ontologies with COX6A2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for COX6A2:
     Decreased POU5F1-GFP protein e  Decreased homologous recombina  Increased cell number in G1, s 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cox6a2):
     cardiovascular system 

    Find genes that share phenotypes with COX6A2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cox6a2tm1Djg for COX6A2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COX6A2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for COX6A2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COX6A2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COX6A2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CX6A2_HUMAN, Q02221: Mitochondrion inner membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    extracellular1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane ----
    GO:0005751mitochondrial respiratory chain complex IV IEA--

    Find genes that share ontologies with COX6A2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for COX6A2 About    
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Electron Transport Chain0.75
    Huntington's disease0.45
    Oxidative phosphorylation0.64
    Non-alcoholic fatty liver disease (NAFLD)0.41
    Parkinson's disease0.57
    2Alzheimer's disease
    Alzheimer's disease0.44
    3Metabolism
    Metabolic pathways0.38
    4Cardiac muscle contraction
    Cardiac muscle contraction
    5AMPK Enzyme Complex Pathway
    AMPK Enzyme Complex Pathway


    Find genes that share SuperPaths with COX6A2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for COX6A2
        AMPK Enzyme Complex Pathway

    1 BioSystems Pathway for COX6A2
        Electron Transport Chain


    Selected Kegg Pathways  (Kegg details for COX6A2) (see all 7):
        Oxidative phosphorylation
    Metabolic pathways
    Cardiac muscle contraction
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease

        Pathway & Disease-focused RT2 Profiler PCR Array including COX6A2: 
              Mitochondrial Energy Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for COX6A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COX6A2 (ENSP000002874904) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COX5AENSP000003177804STRING: ENSP00000317780
    COX7A1ENSP000002929074STRING: ENSP00000292907
    CYC1ENSP000003171594STRING: ENSP00000317159
    MT-CO2ENSP000003548764STRING: ENSP00000354876
    UQCR10ENSP000003328874STRING: ENSP00000332887
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006091generation of precursor metabolites and energy TAS9284905

    Find genes that share ontologies with COX6A2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COX6A2 (CX6A2)

    2 HMDB Compounds for COX6A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for COX6A2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cholic Acid-- 81-25-4target--10592235
    N-Formylmethionine-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for COX6A2 gene: 
    NM_005205.3  

    Unigene Cluster for COX6A2:

    Cytochrome c oxidase subunit VIa polypeptide 2
    Hs.250760  [show with all ESTs]
    Unigene Representative Sequence: BP317375
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000287490(uc002ebx.2) ENST00000565462
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat COX6A2
      QuantiFast Probe-based Assays in human, mouse, rat COX6A2

    Additional mRNA sequence: 

    BC029818.1 HE647858.1 M83308.1 

    4 DOTS entries:

    DT.449545  DT.120690356  DT.120690359  DT.91752764 

    Selected AceView cDNA sequences (see all 246):

    F34132 AJ711352 F26603 F29339 F25431 F17991 F26881 BX104124 
    F29982 F36839 F28062 F24380 NM_005205 F28735 F27292 C05267 
    AJ572299 BC029818 F32256 BM712970 F33734 AW950047 C04692 F29387 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COX6A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTTGCCTC
    COX6A2 Expression
    About this image


    COX6A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Heart (Cardiovascular System)
             Heart Tube
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     Skeletal Muscle (Muscoskeletal System)
    COX6A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COX6A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.250760

    UniProtKB/Swiss-Prot: CX6A2_HUMAN, Q02221
    Tissue specificity: Expressed specifically in heart and muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including COX6A2: 
              Mitochondrial Energy Metabolism in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for COX6A2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cox6a21 , 5 cytochrome c oxidase, subunit VI a, polypeptide 25
    cytochrome c oxidase subunit VIa polypeptide 21
    80.07(n)1
    78.35(a)1
      7 (70.04 cM)5
    128621  NM_009943.21  NP_034073.21 
     1282054365 
    zebrafish
    (Danio rerio)
    Actinopterygii cox6a26
    cytochrome c oxidase subunit VIa polypeptide 2
    56(a)
    1 ↔ 1
    3(31191042-31193221) ENSDARG00000054588
    fruit fly
    (Drosophila melanogaster)
    Insecta levy6
    CG300936
    (see all 3)
    --
    39(a)
    39(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2R(19435763-19436505)
    2R(11831548-11832072)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1746
    Protein TAG-174 (tag-174) mRNA, complete cds
    24(a)
    1 → many
    III(5081726-5083007) WBGene00006519


    ENSEMBL Gene Tree for COX6A2 (if available)
    TreeFam Gene Tree for COX6A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for COX6A2 gene
    COX6A12  COX6A1P22  
    2 SIMAP similar genes for COX6A2 using alignment to 2 protein entries:     CX6A2_HUMAN (see all proteins):
    COX6A1    COX6A1P2

    Find genes that share paralogs with COX6A2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COX6A2 (see all 78)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs770230041,2
    C,F--31438812(+) GGTGTG/ATGTGA 1 -- ds50011Minor allele frequency- A:0.04EA 120
    rs801339041,2
    C--31438841(+) ACCAGG/ATGAGA 1 -- ds50012Minor allele frequency- A:0.05CSA WA 120
    rs756821561,2
    C,F--31438844(+) AGGTGA/GGAGAC 1 -- ds50011Minor allele frequency- G:0.10WA 118
    rs740155231,2
    C,F--31438968(+) AGGAGC/TGCTTA 1 -- ds50012Minor allele frequency- T:0.10WA 120
    rs1857757371,2
    --31439014(+) GGCGCG/TCTCCC 1 -- ds50010--------
    rs2015133001,2
    --31439066(+) CACACA/CTTTAT 1 -- ut310--------
    rs2018770251,2
    --31439097(+) GCCTCA/GGGGGT 2 R * stop-lost0--------
    rs2008139601,2
    C--31439152(+) AGAGTG/ATGGTT 2 /H syn11Minor allele frequency- A:0.00EU 623
    rs122401,2
    C,F,H--31439170(-) TACCCC/TTGGGG 2 P syn116Minor allele frequency- T:0.07NS EA WA NA EU 7065
    rs1483078901,2
    C,F--31439172(+) CCAGGG/CGTAGG 2 /P /A mis11Minor allele frequency- C:0.00NA 4386

    HapMap Linkage Disequilibrium report for COX6A2 (31439052 - 31439967 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for COX6A2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833194CNV Loss17160897
    dgv2673n71CNV Loss21882294
    nsv905751CNV Loss21882294
    nsv905747CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602009    OMIM disorders: --


    Find genes that share disorders with COX6A2           About GenesLikeMe


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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COX6A2 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with COX6A2)
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    1. Structure of the human gene (COX6A2) for the heart/muscle isoform of cytochrome c oxidase subunit VIa and its chromosomal location in humans, mice, and cattle. (PubMed id 9177785)1, 2, 3, 9 Bachman N.J....Lomax M.I. (Genomics 1997)
    2. Differential expression of genes specifying two isoforms of subunit VIa of human cytochrome c oxidase. (PubMed id 1327966)1, 2, 3 Fabrizi G.M.... Schon E.A. (Gene 1992)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. HIV-1 Tat protein directly induces mitochondrial membrane permeabilization and inactivates cytochrome c oxidase. (PubMed id 22419111)1 Lecoeur H....Jacotot E. (amp 2012)
    6. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (Nucleic Acids Res. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1339 HGNC: 2279 AceView: COX6A2andMGC46336 Ensembl:ENSG00000156885 euGenes: HUgn1339
    ECgene: COX6A2 Kegg: 1339 H-InvDB: COX6A2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for COX6A2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for COX6A2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for COX6A2 gene:
    Search GeneIP for patents involving COX6A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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