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Aliases for COX6A2 Gene

Aliases for COX6A2 Gene

  • Cytochrome C Oxidase Subunit 6A2 2 3
  • Cytochrome C Oxidase Subunit VIa Polypeptide 2 2 3 5
  • Cytochrome C Oxidase Polypeptide VIa-Heart 3 4
  • Cytochrome C Oxidase Subunit VIA-Muscle 3 4
  • COX VIa-M 3 4
  • COXVIAH 3 4
  • COX6AH 3 4
  • COX6A 4

External Ids for COX6A2 Gene

Previous GeneCards Identifiers for COX6A2 Gene

  • GC16U990015
  • GC16M031935
  • GC16M031435
  • GC16M031475
  • GC16M031346
  • GC16M028999

Summaries for COX6A2 Gene

Entrez Gene Summary for COX6A2 Gene

  • Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (heart/muscle isoform) of subunit VIa, and polypeptide 2 is present only in striated muscles. Polypeptide 1 (liver isoform) of subunit VIa is encoded by a different gene, and is found in all non-muscle tissues. These two polypeptides share 66% amino acid sequence identity. [provided by RefSeq, Jul 2008]

GeneCards Summary for COX6A2 Gene

COX6A2 (Cytochrome C Oxidase Subunit 6A2) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include cytochrome-c oxidase activity. An important paralog of this gene is COX6A1.

UniProtKB/Swiss-Prot for COX6A2 Gene

  • This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX6A2 Gene

Genomics for COX6A2 Gene

Regulatory Elements for COX6A2 Gene

Enhancers for COX6A2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around COX6A2 on UCSC Golden Path with GeneCards custom track

Promoters for COX6A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COX6A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for COX6A2 Gene

31,427,731 bp from pter
31,428,428 bp from pter
698 bases
Minus strand

Genomic View for COX6A2 Gene

Genes around COX6A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX6A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX6A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX6A2 Gene

Proteins for COX6A2 Gene

  • Protein details for COX6A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome c oxidase subunit 6A2, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • O00761
    • Q6GTW6

    Protein attributes for COX6A2 Gene

    97 amino acids
    Molecular mass:
    10815 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX6A2 Gene

Proteomics data for COX6A2 Gene at MOPED

Post-translational modifications for COX6A2 Gene

  • Ubiquitination at Lys 70
  • Modification sites at PhosphoSitePlus

Other Protein References for COX6A2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COX6A2 Gene

Domains & Families for COX6A2 Gene

Protein Domains for COX6A2 Gene

Suggested Antigen Peptide Sequences for COX6A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome c oxidase subunit 6A family.
  • Belongs to the cytochrome c oxidase subunit 6A family.
genes like me logo Genes that share domains with COX6A2: view

Function for COX6A2 Gene

Molecular function for COX6A2 Gene

GENATLAS Biochemistry:
cytochrome c oxidase,subunit VIa2,component of the complex IV,terminal enzyme complex for electron transfert,oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
genes like me logo Genes that share phenotypes with COX6A2: view

Animal Models for COX6A2 Gene

MGI Knock Outs for COX6A2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for COX6A2 Gene

Localization for COX6A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX6A2 Gene

Mitochondrion inner membrane.

Subcellular locations from

Jensen Localization Image for COX6A2 Gene COMPARTMENTS Subcellular localization image for COX6A2 gene
Compartment Confidence
mitochondrion 5
extracellular 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for COX6A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IEA --
genes like me logo Genes that share ontologies with COX6A2: view

Pathways & Interactions for COX6A2 Gene

genes like me logo Genes that share pathways with COX6A2: view

Pathways by source for COX6A2 Gene

Interacting Proteins for COX6A2 Gene

Gene Ontology (GO) - Biological Process for COX6A2 Gene


No data available for SIGNOR curated interactions for COX6A2 Gene

Drugs & Compounds for COX6A2 Gene

(2) Drugs for COX6A2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cholic acid Approved Pharma Full agonist, Agonist, Target 0
N-Formylmethionine Experimental Pharma Target 0

(2) Additional Compounds for COX6A2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with COX6A2: view

Transcripts for COX6A2 Gene

mRNA/cDNA for COX6A2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(246) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for COX6A2 Gene

Cytochrome c oxidase subunit VIa polypeptide 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COX6A2 Gene

No ASD Table

Relevant External Links for COX6A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COX6A2 Gene

mRNA expression in normal human tissues for COX6A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COX6A2 Gene

This gene is overexpressed in Muscle - Skeletal (x22.1), Heart - Left Ventricle (x19.5), and Heart - Atrial Appendage (x9.9).

Protein differential expression in normal tissues from HIPED for COX6A2 Gene

This gene is overexpressed in Fetal heart (45.5) and Heart (23.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for COX6A2 Gene

SOURCE GeneReport for Unigene cluster for COX6A2 Gene Hs.250760

mRNA Expression by UniProt/SwissProt for COX6A2 Gene

Tissue specificity: Expressed specifically in heart and muscle.
genes like me logo Genes that share expression patterns with COX6A2: view

Protein tissue co-expression partners for COX6A2 Gene

- Elite partner

Primer Products

Orthologs for COX6A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for COX6A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia COX6A2 35
  • 82.82 (n)
  • 80.41 (a)
COX6A2 36
  • 80 (a)
(Canis familiaris)
Mammalia COX6A2 35
  • 82.13 (n)
  • 81.44 (a)
COX6A2 36
  • 81 (a)
(Mus musculus)
Mammalia Cox6a2 35
  • 80.07 (n)
  • 78.35 (a)
Cox6a2 16
Cox6a2 36
  • 78 (a)
(Pan troglodytes)
Mammalia COX6A2 35
  • 99.66 (n)
  • 100 (a)
COX6A2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cox6a2 35
  • 78.01 (n)
  • 77.32 (a)
(Monodelphis domestica)
Mammalia COX6A2 36
  • 78 (a)
(Danio rerio)
Actinopterygii cox6a2 36
  • 56 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14077 36
  • 11 (a)
CG30093 36
  • 39 (a)
levy 36
  • 39 (a)
(Caenorhabditis elegans)
Secernentea tag-174 36
  • 24 (a)
Species with no ortholog for COX6A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for COX6A2 Gene

Gene Tree for COX6A2 (if available)
Gene Tree for COX6A2 (if available)

Paralogs for COX6A2 Gene

Paralogs for COX6A2 Gene

(2) SIMAP similar genes for COX6A2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with COX6A2: view

Variants for COX6A2 Gene

Sequence variations from dbSNP and Humsavar for COX6A2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs12240 -- 31,427,849(-) TACCC(C/T)TGGGG reference, synonymous-codon
rs61043232 -- 31,428,634(+) AAATA(A/T)TTGTA upstream-variant-2KB
rs78827257 -- 31,429,922(+) TTATT(C/T)CTGAG upstream-variant-2KB
rs1799756 -- 31,428,649(-) GACAC(-/TT)AATTC upstream-variant-2KB
rs72789324 -- 31,429,111(+) ACCCT(C/G)GATGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for COX6A2 Gene

Variant ID Type Subtype PubMed ID
nsv833194 CNV Loss 17160897
nsv905747 CNV Gain 21882294
dgv2673n71 CNV Loss 21882294
nsv905751 CNV Loss 21882294

Variation tolerance for COX6A2 Gene

Residual Variation Intolerance Score: 63.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for COX6A2 Gene

Disorders for COX6A2 Gene

Relevant External Links for COX6A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for COX6A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX6A2 Gene

Publications for COX6A2 Gene

  1. Structure of the human gene (COX6A2) for the heart/muscle isoform of cytochrome c oxidase subunit VIa and its chromosomal location in humans, mice, and cattle. (PMID: 9177785) Bachman N.J. … Lomax M.I. (Genomics 1997) 2 3 4 23 67
  2. The Protein Data Bank. (PMID: 10592235) Berman H.M. … Bourne P.E. (Nucleic Acids Res. 2000) 25 26
  3. Differential expression of genes specifying two isoforms of subunit VIa of human cytochrome c oxidase. (PMID: 1327966) Fabrizi G.M. … Schon E.A. (Gene 1992) 2 3
  4. HIV-1 Tat protein directly induces mitochondrial membrane permeabilization and inactivates cytochrome c oxidase. (PMID: 22419111) Lecoeur H. … Jacotot E. (Cell Death Dis 2012) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for COX6A2 Gene

Sources for COX6A2 Gene