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Aliases for COX6A2 Gene

Aliases for COX6A2 Gene

  • Cytochrome C Oxidase Subunit VIa Polypeptide 2 2 3
  • Cytochrome C Oxidase Polypeptide VIa-Heart 3 4
  • Cytochrome C Oxidase Subunit VIA-Muscle 3 4
  • COX VIa-M 3 4
  • COXVIAH 3 4
  • COX6AH 3 4
  • Cytochrome C Oxidase Subunit 6A2, Mitochondrial 3
  • COX6A 4

External Ids for COX6A2 Gene

Summaries for COX6A2 Gene

Entrez Gene Summary for COX6A2 Gene

  • Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (heart/muscle isoform) of subunit VIa, and polypeptide 2 is present only in striated muscles. Polypeptide 1 (liver isoform) of subunit VIa is encoded by a different gene, and is found in all non-muscle tissues. These two polypeptides share 66% amino acid sequence identity. [provided by RefSeq, Jul 2008]

GeneCards Summary for COX6A2 Gene

COX6A2 (Cytochrome C Oxidase Subunit VIa Polypeptide 2) is a Protein Coding gene. Among its related pathways are Metabolism and AMPK Enzyme Complex Pathway. GO annotations related to this gene include cytochrome-c oxidase activity. An important paralog of this gene is COX6A1.

UniProtKB/Swiss-Prot for COX6A2 Gene

  • This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX6A2 Gene

Genomics for COX6A2 Gene

Genomic Location for COX6A2 Gene

31,427,731 bp from pter
31,428,428 bp from pter
698 bases
Minus strand

Genomic View for COX6A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COX6A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX6A2 Gene

Regulatory Elements for COX6A2 Gene

Proteins for COX6A2 Gene

  • Protein details for COX6A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome c oxidase subunit 6A2, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • O00761
    • Q6GTW6

    Protein attributes for COX6A2 Gene

    97 amino acids
    Molecular mass:
    10815 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX6A2 Gene

Proteomics data for COX6A2 Gene at MOPED

Post-translational modifications for COX6A2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys70

Other Protein References for COX6A2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COX6A2 Gene

Domains for COX6A2 Gene

Gene Families for COX6A2 Gene

  • comIV :Mitochondrial respiratory chain complex / Complex IV

Protein Domains for COX6A2 Gene


  • Belongs to the cytochrome c oxidase subunit 6A family.:
    • Q02221
genes like me logo Genes that share domains with COX6A2: view

Function for COX6A2 Gene

Molecular function for COX6A2 Gene

GENATLAS Biochemistry: cytochrome c oxidase,subunit VIa2,component of the complex IV,terminal enzyme complex for electron transfert,oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Gene Ontology (GO) - Molecular Function for COX6A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 cytochrome-c oxidase activity IEA --
genes like me logo Genes that share ontologies with COX6A2: view
genes like me logo Genes that share phenotypes with COX6A2: view

Animal Models for COX6A2 Gene

MGI Knock Outs for COX6A2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for COX6A2 Gene

Localization for COX6A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX6A2 Gene

Mitochondrion inner membrane.

Subcellular locations from

Jensen Localization Image for COX6A2 Gene COMPARTMENTS Subcellular localization image for COX6A2 gene
Compartment Confidence
mitochondrion 5
extracellular 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for COX6A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane --
GO:0005751 mitochondrial respiratory chain complex IV IEA --
genes like me logo Genes that share ontologies with COX6A2: view

Pathways for COX6A2 Gene

genes like me logo Genes that share pathways with COX6A2: view

Pathways by source for COX6A2 Gene

Interacting Proteins for COX6A2 Gene

Gene Ontology (GO) - Biological Process for COX6A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy TAS 9284905
GO:1902600 hydrogen ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with COX6A2: view

Compounds for COX6A2 Gene

(2) HMDB Compounds for COX6A2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Oxygen
  • Dihydrogen oxide

(2) Drugbank Compounds for COX6A2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cholic Acid
81-25-4 target
genes like me logo Genes that share compounds with COX6A2: view

Transcripts for COX6A2 Gene

mRNA/cDNA for COX6A2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(246) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for COX6A2 Gene

Cytochrome c oxidase subunit VIa polypeptide 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COX6A2 Gene

No ASD Table

Relevant External Links for COX6A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COX6A2 Gene

mRNA expression in normal human tissues for COX6A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COX6A2 Gene

This gene is overexpressed in Muscle - Skeletal (22.1), Heart - Left Ventricle (19.5), and Heart - Atrial Appendage (9.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for COX6A2 Gene

SOURCE GeneReport for Unigene cluster for COX6A2 Gene Hs.250760

mRNA Expression by UniProt/SwissProt for COX6A2 Gene

Tissue specificity: Expressed specifically in heart and muscle.
genes like me logo Genes that share expressions with COX6A2: view

Orthologs for COX6A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for COX6A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COX6A2 36
  • 99.66 (n)
  • 100 (a)
COX6A2 37
  • 100 (a)
(Bos Taurus)
Mammalia COX6A2 36
  • 82.82 (n)
  • 80.41 (a)
COX6A2 37
  • 80 (a)
(Canis familiaris)
Mammalia COX6A2 36
  • 82.13 (n)
  • 81.44 (a)
COX6A2 37
  • 81 (a)
(Mus musculus)
Mammalia Cox6a2 36
  • 80.07 (n)
  • 78.35 (a)
Cox6a2 16
Cox6a2 37
  • 78 (a)
(Monodelphis domestica)
Mammalia COX6A2 37
  • 78 (a)
(Rattus norvegicus)
Mammalia Cox6a2 36
  • 78.01 (n)
  • 77.32 (a)
(Danio rerio)
Actinopterygii cox6a2 37
  • 56 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14077 37
  • 11 (a)
CG30093 37
  • 39 (a)
levy 37
  • 39 (a)
(Caenorhabditis elegans)
Secernentea tag-174 37
  • 24 (a)
Species with no ortholog for COX6A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for COX6A2 Gene

Gene Tree for COX6A2 (if available)
Gene Tree for COX6A2 (if available)

Paralogs for COX6A2 Gene

Paralogs for COX6A2 Gene

Selected SIMAP similar genes for COX6A2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with COX6A2: view

Variants for COX6A2 Gene

Sequence variations from dbSNP and Humsavar for COX6A2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs12240 -- 31,427,849(-) TACCC(C/T)TGGGG reference, synonymous-codon
rs1799756 -- 31,428,649(-) GACAC(-/TT)AATTC upstream-variant-2KB
rs8049023 -- 31,429,022(+) ATAGC(C/T)AGAGA upstream-variant-2KB
rs8049666 -- 31,429,015(+) GTCTG(A/G)TATAG upstream-variant-2KB
rs8054594 -- 31,428,724(+) aaata(A/C)tggag upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for COX6A2 Gene

Variant ID Type Subtype PubMed ID
nsv833194 CNV Loss 17160897
nsv905747 CNV Gain 21882294
dgv2673n71 CNV Loss 21882294
nsv905751 CNV Loss 21882294

Relevant External Links for COX6A2 Gene

HapMap Linkage Disequilibrium report

Disorders for COX6A2 Gene

No disorders were found for COX6A2 Gene.

No data available for UniProtKB/Swiss-Prot for COX6A2 Gene

Publications for COX6A2 Gene

  1. Structure of the human gene (COX6A2) for the heart/muscle isoform of cytochrome c oxidase subunit VIa and its chromosomal location in humans, mice, and cattle. (PMID: 9177785) Bachman N.J. … Lomax M.I. (Genomics 1997) 2 3 4 23
  2. Differential expression of genes specifying two isoforms of subunit VIa of human cytochrome c oxidase. (PMID: 1327966) Fabrizi G.M. … Schon E.A. (Gene 1992) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for COX6A2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate COX6A2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for COX6A2
    • Block miRNA regulation of COX6A2 using miScript Target Protectors

    Sources for COX6A2 Gene

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