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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COX6A2 Gene

protein-coding   GIFtS: 55
GCID: GC16M031439

Cytochrome C Oxidase Subunit VIa Polypeptide 2

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cytochrome C Oxidase Subunit VIa Polypeptide 21 2     COXVIAH2 3
Cytochrome C Oxidase Polypeptide VIa-Heart2 3     COX VIa-M2 3
Cytochrome C Oxidase Subunit VIA-Muscle2 3     Cytochrome C Oxidase Subunit 6A2, Mitochondrial2
COX6AH2 3     COX6A3

External Ids:    HGNC: 22791   Entrez Gene: 13392   Ensembl: ENSG000001568857   OMIM: 6020095   UniProtKB: Q022213   

Export aliases for COX6A2 gene to outside databases

Previous GC identifers: GC16U990015 GC16M031935 GC16M031435 GC16M031475 GC16M031346 GC16M028999


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COX6A2 Gene:
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron
transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits
encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The
mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved
in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (heart/muscle isoform) of
subunit VIa, and polypeptide 2 is present only in striated muscles. Polypeptide 1 (liver isoform) of subunit VIa
is encoded by a different gene, and is found in all non-muscle tissues. These two polypeptides share 66% amino
acid sequence identity. (provided by RefSeq, Jul 2008)

GeneCards Summary for COX6A2 Gene: 
COX6A2 (cytochrome c oxidase subunit VIa polypeptide 2) is a protein-coding gene. Diseases associated with COX6A2 include huntington's disease, and parkinson's disease, and among its related super-pathways are Electron Transport Chain and Metabolism. GO annotations related to this gene include cytochrome-c oxidase activity. An important paralog of this gene is COX6A1.

UniProtKB/Swiss-Prot: CX6A2_HUMAN, Q02221
Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal
oxidase in mitochondrial electron transport




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COX6A2 gene promoter:
         Elk-1   AML1a   GCNF   GATA-1   RORalpha1   Egr-2   AREB6   GCNF-1   GCNF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOX6A2 promoter sequence
   Search SABiosciences Chromatin IP Primers for COX6A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COX6A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.12   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.12

COX6A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COX6A2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M031439:  view genomic region     (about GC identifiers)

Start:
31,439,052 bp from pter      End:
31,439,967 bp from pter
Size:
916 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CX6A2_HUMAN, Q02221 (See protein sequence)
Recommended Name: Cytochrome c oxidase subunit 6A2, mitochondrial precursor  
Size: 97 amino acids; 10815 Da
Subcellular location: Mitochondrion inner membrane
Secondary accessions: O00761 Q6GTW6

Explore the universe of human proteins at neXtProt for COX6A2: NX_Q02221

Explore proteomics data for COX6A2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q02221

  • COX6A2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    COX6A2 Protein Expression
    REFSEQ proteins: NP_005196.1  
    ENSEMBL proteins: 
     ENSP00000287490  

    Human Recombinant Protein Products for COX6A2: 
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    Novus Biologicals COX6A2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane ----
    GO:0005751mitochondrial respiratory chain complex IV IEA--

    COX6A2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    comIV: Mitochondrial respiratory chain complex / Complex IV

    2 InterPro protein domains:
     IPR018507 Cyt_c_oxidase_su6a_CS
     IPR001349 Cyt_c_oxidase_su6a

    Graphical View of Domain Structure for InterPro Entry Q02221

    ProtoNet protein and cluster: Q02221

    1 Blocks protein domain: IPB001349 Cytochrome c oxidase

    UniProtKB/Swiss-Prot: CX6A2_HUMAN, Q02221
    Similarity: Belongs to the cytochrome c oxidase subunit 6A family


    COX6A2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CX6A2_HUMAN, Q02221
    Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal
    oxidase in mitochondrial electron transport

         Genatlas biochemistry entry for COX6A2:
    cytochrome c oxidase,subunit VIa2,component of the complex IV,terminal enzyme complex for electron
    transfert,oxidative phosphorylation (OXPHOS),inner mitochondrial membrane

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004129cytochrome-c oxidase activity IEA--
         
    COX6A2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for COX6A2:
     Decreased POU5F1-GFP protein e  Decreased homologous recombina  Increased cell number in G1, s 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cox6a2):
     cardiovascular system 

    COX6A2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cox6a2tm1Djg for COX6A2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for COX6A2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for COX6A2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COX6A2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COX6A2 

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    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX6A2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for COX6A2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Electron Transport Chain0.75
    Huntington's disease0.47
    Oxidative phosphorylation0.64
    Alzheimer's disease0.46
    Parkinson's disease0.61
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolic pathways0.40
    3Cardiac muscle contraction
    Cardiac muscle contraction
    4AMPK Enzyme Complex Pathway
    AMPK Enzyme Complex Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for COX6A2
        AMPK Enzyme Complex Pathway

    1 BioSystems Pathway for COX6A2
        Electron Transport Chain


    5/7         Kegg Pathways  (Kegg details for COX6A2) (see all 7):
        Oxidative phosphorylation
    Metabolic pathways
    Cardiac muscle contraction
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease


    COX6A2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COX6A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/24 Interacting proteins for COX6A2 (ENSP000002874904) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COX4I2ENSP000003652434STRING: ENSP00000365243
    COX6A1ENSP000002293794STRING: ENSP00000229379
    MT-CO1ENSP000003544994STRING: ENSP00000354499
    COX5BENSP000002584244STRING: ENSP00000258424
    MT-CO3ENSP000003549824STRING: ENSP00000354982
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006091generation of precursor metabolites and energy TAS9284905

    COX6A2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for COX6A2 (CX6A2)

    2 HMDB Compounds for COX6A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for COX6A2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cholic Acid-- 81-25-4target--10592235
    N-Formylmethionine-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about COX6A2 / CX6A2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for COX6A2 gene: 
    NM_005205.3  

    Unigene Cluster for COX6A2:

    Cytochrome c oxidase subunit VIa polypeptide 2
    Hs.250760  [show with all ESTs]
    Unigene Representative Sequence: BP317375
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000287490(uc002ebx.2) ENST00000565462

    miRNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COX6A2
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    Additional mRNA sequence: 

    BC029818.1 HE647858.1 M83308.1 

    4 DOTS entries:

    DT.449545  DT.120690356  DT.120690359  DT.91752764 

    24/246 AceView cDNA sequences (see all 246):

    BX104124 F29982 F26881 F26603 F25431 F30382 F27292 F34132 
    F28735 NM_005205 F29339 F33734 AW950047 C04692 F29387 BC036762 
    F24171 F29936 BM715485 BC029818 F32256 F36839 F28062 BM712970 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COX6A2 expression in normal human tissues (normalized intensities)      COX6A2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTTGCCTC
    COX6A2 Expression
    About this image


    COX6A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Heart Tube
             heart/ventricle   
     
     Blood (Muscoskeletal System)    fully expand to see all 2 entries
             Human Mesenchymal Stem Cell-bone marrow (HMSC-Bone Marrow)   
             mouse/organ system/cardiovascular system   
     
     Skeletal Muscle (Muscoskeletal System)
             vastus lateralis   
     
     Limb (Muscoskeletal System)
             limb/hindlimb   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut

    See COX6A2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COX6A2

    SOURCE GeneReport for Unigene cluster: Hs.250760

    UniProtKB/Swiss-Prot: CX6A2_HUMAN, Q02221
    Tissue specificity: Expressed specifically in heart and muscle

        SABiosciences Expression via Pathway-Focused PCR Array including COX6A2: 
              Mitochondrial Energy Metabolism in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX6A2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for COX6A2 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cox6a21 , 5 cytochrome c oxidase, subunit VI a, polypeptide 25
    cytochrome c oxidase subunit VIa polypeptide 21
    80.07(n)1
    78.35(a)1
      7 (70.04 cM)5
    128621  NM_009943.21  NP_034073.21 
     1282054365 
    chicken
    (Gallus gallus)
    Aves COX6A16
    Cytochrome c oxidase subunit 6A, mitochondrial
    48(a)
    1 → many
    15(9297230-9298519)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Cytochrome c oxidase subunit 6A, mitochondrial
    50(a)
    1 → many
    GL343338.1(67098-69371)
    zebrafish
    (Danio rerio)
    Actinopterygii cox6a21 cytochrome c oxidase subunit VIa polypeptide 2 64.77(n)
    64.77(a)
      447942  NM_001004680.1  NP_001004680.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG300936
    levy6
    (see all 3)
    levy
    (see all 3)
    40(a)
    38(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2R(11831548-11832072)
    2R(19435763-19436505)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1746
    Probable cytochrome c oxidase subunit 6A, mitochon...
    23(a)
    1 → many
    III(5081724-5083007)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes COX136
    Subunit VIa of cytochrome c oxidase, which is the ...
    20(a)
    1 → many
    VII(144808-145197)


    ENSEMBL Gene Tree for COX6A2 (if available)
    TreeFam Gene Tree for COX6A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for COX6A2 gene
    COX6A12  COX6A1P22  
    2 SIMAP similar genes for COX6A2 using alignment to 2 protein entries:     CX6A2_HUMAN (see all proteins):
    COX6A1    COX6A1P2

    COX6A2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/78 SNPs in COX6A2 are shown (see all 78)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs770230041,2
    C,F--31438812(+) GGTGTG/ATGTGA 1 -- ds50011Minor allele frequency- A:0.04EA 120
    rs801339041,2
    C--31438841(+) ACCAGG/ATGAGA 1 -- ds50012Minor allele frequency- A:0.05CSA WA 120
    rs756821561,2
    C,F--31438844(+) AGGTGA/GGAGAC 1 -- ds50011Minor allele frequency- G:0.10WA 118
    rs740155231,2
    C,F--31438968(+) AGGAGC/TGCTTA 1 -- ds50012Minor allele frequency- T:0.10WA 120
    rs1857757371,2
    --31439014(+) GGCGCG/TCTCCC 1 -- ds50010--------
    rs2015133001,2
    --31439066(+) CACACA/CTTTAT 1 -- ut310--------
    rs2018770251,2
    --31439097(+) GCCTCA/GGGGGT 2 R * stop-lost0--------
    rs2008139601,2
    C--31439152(+) AGAGTG/ATGGTT 2 /H syn11Minor allele frequency- A:0.00EU 623
    rs122401,2
    C,F,H--31439170(-) TACCCC/TTGGGG 2 P syn116Minor allele frequency- T:0.07NS EA WA NA EU 7065
    rs1483078901,2
    C,F--31439172(+) CCAGGG/CGTAGG 2 /P /A mis11Minor allele frequency- C:0.00NA 4386

    HapMap Linkage Disequilibrium report for COX6A2 (31439052 - 31439967 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for COX6A2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833194CNV Loss17160897
    dgv2673n71CNV Loss21882294
    nsv905751CNV Loss21882294
    nsv905747CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602009    OMIM disorders: --

    3 diseases for COX6A2:    About MalaCards
    huntington's disease    parkinson's disease    alzheimer's disease


    COX6A2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for COX6A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COX6A2 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with COX6A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the human gene (COX6A2) for the heart/muscle isoform of cytochrome c oxidase subunit VIa and its chromosomal location in humans, mice, and cattle. (PubMed id 9177785)1, 2, 3, 9 Bachman N.J....Lomax M.I. (1997)
    2. Differential expression of genes specifying two isoforms of subunit VIa of human cytochrome c oxidase. (PubMed id 1327966)1, 2, 3 Fabrizi G.M.... Schon E.A. (1992)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. HIV-1 Tat protein directly induces mitochondrial membr ane permeabilization and inactivates cytochrome c oxidase. (PubMed id 22419111)1 Lecoeur H....Jacotot E. (2012)
    5. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (2000)
    10. Assignment of COX6A1 to 6p21 and a pseudogene (COX6A1P) to 1p31.1 by in situ hybridization and somatic cell hybrids. (PubMed id 9284905)1 Hey Y....Varley J.M. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1339 HGNC: 2279 AceView: COX6A2andMGC46336 Ensembl:ENSG00000156885 euGenes: HUgn1339
    ECgene: COX6A2 Kegg: 1339 H-InvDB: COX6A2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COX6A2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for COX6A2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for COX6A2 gene:
    Search GeneIP for patents involving COX6A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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