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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COX6A1 Gene

protein-coding   GIFtS: 60
GCID: GC12P120875

cytochrome c oxidase subunit VIa polypeptide 1


(Previous symbol: COX6A)
 Explore 4 diseases affiliated with
COX6A1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for COX6A1    

Aliases
for COX6A1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cytochrome C Oxidase Subunit VIa Polypeptide 11 2     COX6AL2 3
COX6A1 2     COX VIa-L2 3
Cytochrome C Oxidase Polypeptide VIa-Liver2 3     Cytochrome C Oxidase Subunit 6A1, Mitochondrial2
Cytochrome C Oxidase Subunit VIA-Liver2 3     Cytochrome C Oxidase Subunit VIa Homolog2

External Ids:    HGNC: 22771   Entrez Gene: 13372   Ensembl: ENSG000001117757   OMIM: 6020725   UniProtKB: P120743   

Export aliases for COX6A1 gene to outside databases

Previous GC identifers: GC12P119748 GC12P120402 GC12P120658 GC12P119287 GC12P119338 GC12P117884


Summaries
for COX6A1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for COX6A1:
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer
from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by
mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits
function in the electron transfer and the nuclear-encoded subunits may function in the regulation and assembly of the
complex. This nuclear gene encodes polypeptide 1 (liver isoform) of subunit VIa, and polypeptide 1 is found in all
non-muscle tissues. Polypeptide 2 (heart/muscle isoform) of subunit VIa is encoded by a different gene, and is present
only in striated muscles. These two polypeptides share 66% amino acid sequence identity. It has been reported that
there may be several pseudogenes on chromosomes 1, 6, 7q21, 7q31-32 and 12. However, only one pseudogene (COX6A1P) on
chromosome 1p31.1 has been documented. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CX6A1_HUMAN, P12074
Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in
mitochondrial electron transport

Gene Wiki entry for COX6A1


Genomic Views
for COX6A1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009775.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COX6A1 gene promoter:
         RFX1   Pbx1a   p53   AML1a   Olf-1   MIF-1   Tal-1beta   E47   Max   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: COX6A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for COX6A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COX6A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.2|12q24.2   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24

COX6A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COX6A1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P120875:  view genomic region     (about GC identifiers)

Start:
 120,875,893 bp from pter      End:
 120,878,545 bp from pter
Size:
 2,653 bases      Orientation:
 plus strand

Proteins
for COX6A1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CX6A1_HUMAN, P12074 (See protein sequence)
Recommended Name: Cytochrome c oxidase subunit 6A1, mitochondrial precursor  
Size: 109 amino acids; 12155 Da
Subcellular location: Mitochondrion inner membrane
Sequence caution: Sequence=CAA33392.1; Type=Frameshift; Positions=17;
Secondary accessions: B2R500 O43714 Q32Q37

Explore the universe of human proteins at neXtProt for COX6A1: NX_P12074

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P12074

    • COX6A1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004364.2  
    ENSEMBL proteins: 
     ENSP00000229379  
    Reactome Protein details: P12074
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: COX6A1
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    Novus Biologicals COX6A1 Protein
    Novus Biologicals COX6A1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for COX6A1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005751mitochondrial respiratory chain complex IV IEA--


    COX6A1 for ontologies           About GeneDecksing



    COX6A1 Antibody Products: 
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    ThermoFisher Antibody for COX6A1

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    Uscn ELISAs and CLIAs for COX6A1

    Protein Domains /
    Families
    for COX6A1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    COX6A1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR018507 Cyt_c_oxidase_su6a_CS
     IPR001349 Cyt_c_oxidase_su6a

    Graphical View of Domain Structure for InterPro Entry P12074

    ProtoNet protein and cluster: P12074

    1 Blocks protein family: IPB001349 Cytochrome c oxidase

    UniProtKB/Swiss-Prot: CX6A1_HUMAN, P12074
    Similarity: Belongs to the cytochrome c oxidase subunit 6A family


    Function
    for COX6A1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CX6A1_HUMAN, P12074
    Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in
    mitochondrial electron transport

         Genatlas biochemistry entry for COX6A1:
    cytochrome c oxidase,subunit VIa,polypeptide 1,liver specific,97.5kDa,component of the complex IV,terminal enzyme
    complex for electron transfert,oxidative phosphorylation (OXPHOS),inner mitochondrial membrane

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COX6A1 (see all 3)
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    Cell Line
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    Search LifeMap BioReagents cell lines for COX6A1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX6A1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004129cytochrome-c oxidase activity IEA--


    COX6A1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for COX6A1:
     Decreased nuclei size in G2M 

    Animal Models:
         Mouse knock-out Cox6a1tm1(KOMP)Wtsi for COX6A1
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cox6a1):
     behavior/neurological  craniofacial  growth/size  mortality/aging 

    COX6A1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for COX6A1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.1.00
    		Oxidative phosphorylation0.63
    		Respiratory electron transport0.81
    		Parkinson's disease0.61
    		Electron Transport Chain0.76
    		Alzheimer's disease0.43
    		The citric acid (TCA) cycle and respiratory electron transport0.72
    		Huntington's disease0.40
    2Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    3AMPK Enzyme Complex Pathway
    		AMPK Enzyme Complex Pathway1.00
    4Cardiac muscle contraction
    		Cardiac muscle contraction1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for COX6A1
        AMPK Enzyme Complex Pathway

    1 BioSystems Pathway for COX6A1 
        Electron Transport Chain

    4        Reactome Pathways for COX6A1
        Respiratory electron transport
    Metabolism
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport


    5/6         Kegg Pathways  (Kegg details for COX6A1) (see all 6):
        Oxidative phosphorylation
    Metabolic pathways
    Cardiac muscle contraction
    Alzheimer's disease
    Parkinson's disease


    COX6A1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COX6A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/17 Interacting proteins for COX6A1 (P120743 ENSP000002293794) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629933, ENSP000003390074I2D: score=2 STRING: ENSP00000339007
    COX4I2ENSP000003652434STRING: ENSP00000365243
    COX6A2ENSP000002874904STRING: ENSP00000287490
    MT-CO1ENSP000003544994STRING: ENSP00000354499
    COX5BENSP000002584244STRING: ENSP00000258424
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006091generation of precursor metabolites and energy TAS2549515
    GO:0022904respiratory electron transport chain TAS--
    GO:0044281small molecule metabolic process TAS--


    COX6A1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for COX6A1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for COX6A1

    2 HMDB Compounds for COX6A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    Search CenterWatch for drugs/clinical trials and news about COX6A1 / CX6A1 

    Transcripts
    for COX6A1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for COX6A1 gene: 
    NM_004373.3  

    Unigene Cluster for COX6A1:

    Cytochrome c oxidase subunit VIa polypeptide 1
    Hs.369624  [show with all ESTs]
    Unigene Representative Sequence: BQ433343
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000550009 ENST00000229379(uc001tyf.1) ENST00000549525

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: COX6A1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: COX6A1
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COX6A1
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    Additional cDNA sequence: 

    AF020589.1 AK312009.1 BC007723.2 BC070186.1 BC107861.1 HE647860.1 X15341.1 

    18 DOTS entries:

    DT.450466  DT.100883248  DT.95138953  DT.92071038  DT.101955242  DT.95224370  DT.101986528  DT.95340079 
    DT.429821  DT.99980900  DT.121322895  DT.91758766  DT.121180144  DT.95138866  DT.121180237  DT.95137229 
    DT.121180194  DT.95269819 

    24/841 AceView cDNA sequences (see all 841):

    BM830106 CB160724 AI220514 AI421088 AA482243 BM789153 BM854868 AA085264 
    AI384121 BF431116 BM662994 AW207319 AA025440 BQ218159 BQ011189 AA172206 
    BM843241 AI420343 AU117982 CR612638 BM557702 AI244853 AA861540 BM694231 

    GeneLoc Exon Structure


    Expression
    for COX6A1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COX6A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACCAGAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    COX6A1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See COX6A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COX6A1

    SOURCE GeneReport for Unigene cluster: Hs.369624
        SABiosciences Expression via Pathway-Focused PCR Array including COX6A1: 
              Mitochondrial Energy Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX6A1

    Orthologs
    for COX6A1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for COX6A1 gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cox6a11 , 5 cytochrome c oxidase, subunit VI a, polypeptide 15
    cytochrome c oxidase subunit VIa polypeptide 11    		 82.41(n)1
    84.26(a)1    		   5 (56.06 cM)5
    128611  NM_007748.31  NP_031774.11 
     1153456425 
    chicken
    (Gallus gallus)    		 Aves COX6A11 cytochrome c oxidase subunit VIa polypeptide 1 69.5(n)
    65.09(a)    		   416978  XM_415270.3  XP_415270.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 63(a)
    		 1 → many
    		 GL343338.1(67098-69371)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia CF343832.12   -- 71.53(n)    CF343832.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cox6a11 cytochrome c oxidase subunit VIa polypeptide 1 61.22(n)
    63.46(a)    		   335774  NM_001005592.1  NP_001005592.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta levy1 CG17280-PA 56.73(n)
    50.96(a)    		   37728  NM_137961.2  NP_611805.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea tag-1746
    		 Probable cytochrome c oxidase subunit 6A, mitochon...
    		 23(a)
    		 possible ortholog
    		 III(5081686-5082969)


    ENSEMBL Gene Tree for COX6A1 (if available)
    TreeFam Gene Tree for COX6A1 (if available) 

    Paralogs
    for COX6A1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for COX6A1 gene
    COX6A22  COX6A1P22  
    2 SIMAP similar genes for COX6A1 using alignment to 2 protein entries:     CX6A1_HUMAN (see all proteins):
    COX6A1P2    COX6A2

    COX6A1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for COX6A1
    PGOHUM00000244070 PGOHUM00000235541


    Genomic Variants
    for COX6A1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/121 NCBI SNPs in COX6A1 are shown (see all 121)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2002927841,2
    		C--120873999(+) GTTTTG/TAGACC 1 -- us2k10--------
    rs1850966141,2
    		--120874012(+) AGTCTC/TGCTGT 1 -- us2k10--------
    rs1897787181,2
    		--120874013(+) GTCTCA/GCTGTG 1 -- us2k10--------
    rs1812864961,2
    		--120874021(+) GTGTCA/GCCCAG 1 -- us2k10--------
    rs1483678951,2
    		--120874172(+) GACGGC/TGTTTC 1 -- us2k10--------
    rs116128251,2
    		C,F,H,--120874200(+) GGTCTC/TGAACT 1 -- us2k12Minor allele frequency- T:0.33NA WA 6
    rs1852015131,2
    		--120874234(+) TCTCCA/GCCTCC 1 -- us2k10--------
    rs714546421,2
    		C,F--120874315(+) CAACTG/CTTGTT 1 -- us2k12Minor allele frequency- C:0.50NA 4
    rs579432181,2
    		C,F,--120874395(+) TCCTGC/ACTCAG 1 -- us2k13Minor allele frequency- A:0.50NA 6
    rs1400789331,2
    		--120874447(+) CGGCTA/CATTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for COX6A1 (120875893 - 120878545 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for COX6A1: --

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    Disorders / Diseases
    for COX6A1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    COX6A1 for disorders           About GeneDecksing

    OMIM gene information: 602072    OMIM disorders: --

    4 diseases for COX6A1:    About MalaCards
    goldenhar syndrome    huntington's disease    parkinson's disease    neurodegeneration

    1 disease from the University of Copenhagen DISEASES database for COX6A1:
    Goldenhar syndrome
    Human Genome Epidemiology (HuGE) Navigator: COX6A1 (1 document)

    Export disorders for COX6A1 gene to outside databases

    Publications
    for COX6A1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COX6A1 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with COX6A1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Assignment of COX6A1 to 6p21 and a pseudogene (COX6A1P) to 1p31.1 by in situ hybridization and somatic cell hybrids. (PubMed id 9284905)1, 3 Hey Y....Varley J.M. (1997)
    4. Human liver protein map: a reference database established by microsequencing and gel comparison. (PubMed id 1286669)1, 2 Hochstrasser D.F.... Hughes G.J. (1992)
    5. Sequence of a cDNA specifying subunit VIa of human cytochrome c oxidase. (PubMed id 2549515)1, 2 Fabrizi G.M....Schon E.A. (1989)
    6. Molecular evolution of cytochrome c oxidase: rate variation among subunit VIa isoforms. (PubMed id 9190060)1, 9 Schmidt T.R....Grossman L.I. (1997)
    7. Identification of cytochrome c oxidase subunit 6A1 as a suppressor of Bax-induced cell death by yeast-based functional screening. (PubMed id 18549809)1, 9 Eun S.Y....Seo H.G. (2008)
    8. HIV-1 Tat protein directly induces mitochondrial membr ane permeabilization and inactivates cytochrome c oxidase. (PubMed id 22419111)1 Lecoeur H....Jacotot E. (2012)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Novel insights into the assembly and function of huma n nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b. (PubMed id 20307258)1 Fornuskova D....Zeman J. (2010)

    External Searches for COX6A1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
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    Genome Databases showing COX6A1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1337 HGNC: 2277 AceView: COX6A1and15E1.2 Ensembl:ENSG00000111775 euGenes: HUgn1337
    ECgene: COX6A1 Kegg: 1337 H-InvDB: COX6A1

    Other Databases showing COX6A1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing COX6A1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COX6A1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for COX6A1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for COX6A1 gene:
    Search GeneIP for patents involving COX6A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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