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Aliases for COX6A1 Gene

Aliases for COX6A1 Gene

  • Cytochrome C Oxidase Subunit VIa Polypeptide 1 2 3
  • Cytochrome C Oxidase Polypeptide VIa-Liver 3 4
  • Cytochrome C Oxidase Subunit VIA-Liver 3 4
  • COX VIa-L 3 4
  • COX6AL 3 4
  • Cytochrome C Oxidase Subunit 6A1, Mitochondrial 3
  • Cytochrome C Oxidase Subunit VIa Homolog 3
  • CMTRID 3
  • COX6A 3

External Ids for COX6A1 Gene

Previous Symbols for COX6A1 Gene

  • COX6A

Summaries for COX6A1 Gene

Entrez Gene Summary for COX6A1 Gene

  • Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in the electron transfer and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (liver isoform) of subunit VIa, and polypeptide 1 is found in all non-muscle tissues. Polypeptide 2 (heart/muscle isoform) of subunit VIa is encoded by a different gene, and is present only in striated muscles. These two polypeptides share 66% amino acid sequence identity. It has been reported that there may be several pseudogenes on chromosomes 1, 6, 7q21, 7q31-32 and 12. However, only one pseudogene (COX6A1P) on chromosome 1p31.1 has been documented. [provided by RefSeq, Jul 2008]

GeneCards Summary for COX6A1 Gene

COX6A1 (Cytochrome C Oxidase Subunit VIa Polypeptide 1) is a Protein Coding gene. Diseases associated with COX6A1 include charcot-marie-tooth disease, recessive intermediate d. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include cytochrome-c oxidase activity. An important paralog of this gene is COX6A2.

UniProtKB/Swiss-Prot for COX6A1 Gene

  • This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Gene Wiki entry for COX6A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX6A1 Gene

Genomics for COX6A1 Gene

Genomic Location for COX6A1 Gene

Start:
120,438,090 bp from pter
End:
120,440,742 bp from pter
Size:
2,653 bases
Orientation:
Plus strand

Genomic View for COX6A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COX6A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX6A1 Gene

Regulatory Elements for COX6A1 Gene

Proteins for COX6A1 Gene

  • Protein details for COX6A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12074-CX6A1_HUMAN
    Recommended name:
    Cytochrome c oxidase subunit 6A1, mitochondrial
    Protein Accession:
    P12074
    Secondary Accessions:
    • B2R500
    • O43714
    • Q32Q37

    Protein attributes for COX6A1 Gene

    Size:
    109 amino acids
    Molecular mass:
    12155 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA33392.1; Type=Frameshift; Positions=17; Evidence={ECO:0000305};

neXtProt entry for COX6A1 Gene

Proteomics data for COX6A1 Gene at MOPED

Post-translational modifications for COX6A1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys82

Other Protein References for COX6A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for COX6A1 Gene

Domains for COX6A1 Gene

Gene Families for COX6A1 Gene

HGNC:
  • comIV :Mitochondrial respiratory chain complex / Complex IV

Protein Domains for COX6A1 Gene

UniProtKB/Swiss-Prot:

CX6A1_HUMAN
Family:
  • Belongs to the cytochrome c oxidase subunit 6A family.:
    • P12074
genes like me logo Genes that share domains with COX6A1: view

Function for COX6A1 Gene

Molecular function for COX6A1 Gene

GENATLAS Biochemistry: cytochrome c oxidase,subunit VIa,polypeptide 1,liver specific,97.5kDa,component of the complex IV,terminal enzyme complex for electron transfert,oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Gene Ontology (GO) - Molecular Function for COX6A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 cytochrome-c oxidase activity IEA --
genes like me logo Genes that share ontologies with COX6A1: view

Phenotypes for COX6A1 Gene

genes like me logo Genes that share phenotypes with COX6A1: view

Animal Models for COX6A1 Gene

MGI Knock Outs for COX6A1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for COX6A1 Gene

Localization for COX6A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX6A1 Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COX6A1 Gene COMPARTMENTS Subcellular localization image for COX6A1 gene
Compartment Confidence
mitochondrion 5
cytosol 1
extracellular 1
lysosome 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for COX6A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005751 mitochondrial respiratory chain complex IV IEA --
genes like me logo Genes that share ontologies with COX6A1: view

Pathways for COX6A1 Gene

genes like me logo Genes that share pathways with COX6A1: view

Gene Ontology (GO) - Biological Process for COX6A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy TAS 2549515
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0010467 gene expression TAS --
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
genes like me logo Genes that share ontologies with COX6A1: view

Compounds for COX6A1 Gene

(2) HMDB Compounds for COX6A1 Gene

Compound Synonyms Cas Number PubMed IDs
Oxygen
  • Oxygen
7782-44-7
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with COX6A1: view

Transcripts for COX6A1 Gene

mRNA/cDNA for COX6A1 Gene

Unigene Clusters for COX6A1 Gene

Cytochrome c oxidase subunit VIa polypeptide 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COX6A1 Gene

No ASD Table

Relevant External Links for COX6A1 Gene

GeneLoc Exon Structure for
COX6A1
ECgene alternative splicing isoforms for
COX6A1

Expression for COX6A1 Gene

mRNA expression in normal human tissues for COX6A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COX6A1 Gene

SOURCE GeneReport for Unigene cluster for COX6A1 Gene Hs.369624

genes like me logo Genes that share expressions with COX6A1: view

Orthologs for COX6A1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for COX6A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COX6A1 37
  • 100 (a)
OneToOne
LOC100616508 36
  • 99.69 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia -- 37
  • 83 (a)
ManyToMany
COX6A1 37
  • 84 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 38 (a)
ManyToMany
-- 37
  • 69 (a)
ManyToMany
-- 37
  • 70 (a)
ManyToMany
LOC477508 36
  • 87.04 (n)
  • 83.33 (a)
mouse
(Mus musculus)
Mammalia Cox6a1 36
  • 82.41 (n)
  • 84.26 (a)
Cox6a1 16
Cox6a1 37
  • 81 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 62 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cox6a1 36
  • 84.26 (n)
  • 83.33 (a)
chicken
(Gallus gallus)
Aves COX6A1 36
  • 69.5 (n)
  • 65.09 (a)
COX6A1 37
  • 62 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cox6a1 36
  • 62.26 (n)
  • 62.26 (a)
zebrafish
(Danio rerio)
Actinopterygii cox6a1 36
  • 60.9 (n)
  • 63.46 (a)
cox6a1 37
  • 56 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000851 36
  • 61.33 (n)
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14077 37
  • 14 (a)
ManyToMany
CG30093 37
  • 43 (a)
ManyToMany
levy 36
  • 56.73 (n)
  • 50.96 (a)
levy 37
  • 45 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea tag-174 37
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COX13 39
Species with no ortholog for COX6A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COX6A1 Gene

ENSEMBL:
Gene Tree for COX6A1 (if available)
TreeFam:
Gene Tree for COX6A1 (if available)

Paralogs for COX6A1 Gene

Paralogs for COX6A1 Gene

Selected SIMAP similar genes for COX6A1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for COX6A1 Gene

genes like me logo Genes that share paralogs with COX6A1: view

Variants for COX6A1 Gene

Sequence variations from dbSNP and Humsavar for COX6A1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs8903 -- 120,440,727(+) TTAAA(C/G/T)TTAGA utr-variant-3-prime
rs1732849 -- 120,439,469(-) ctgca(A/C)cctcc intron-variant
rs1732850 -- 120,438,814(-) GAAGT(A/T)aaaaa intron-variant
rs2076022 -- 120,437,987(+) GACTC(C/T)GTCGT upstream-variant-2KB
rs2294287 -- 120,439,310(+) tcgcc(A/G/T)gaggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COX6A1 Gene

Variant ID Type Subtype PubMed ID
nsv509482 CNV Insertion 20534489

Relevant External Links for COX6A1 Gene

HapMap Linkage Disequilibrium report
COX6A1
Human Gene Mutation Database (HGMD)
COX6A1

Disorders for COX6A1 Gene

UniProtKB/Swiss-Prot

CX6A1_HUMAN
  • Charcot-Marie-Tooth disease, recessive, intermediate type, D (CMTRID) [MIM:616039]: A form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Recessive intermediate forms of Charcot-Marie-Tooth disease are characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec. {ECO:0000269 PubMed:25152455}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for COX6A1 Gene

Relevant External Links for COX6A1

Genetic Association Database (GAD)
COX6A1
Human Genome Epidemiology (HuGE) Navigator
COX6A1
genes like me logo Genes that share disorders with COX6A1: view

Publications for COX6A1 Gene

  1. Molecular evolution of cytochrome c oxidase: rate variation among subunit VIa isoforms. (PMID: 9190060) Schmidt T.R. … Grossman L.I. (Mol. Biol. Evol. 1997) 3 23
  2. Identification of cytochrome c oxidase subunit 6A1 as a suppressor of Bax-induced cell death by yeast-based functional screening. (PMID: 18549809) Eun S.Y. … Seo H.G. (Biochem. Biophys. Res. Commun. 2008) 3 23
  3. Human liver protein map: a reference database established by microsequencing and gel comparison. (PMID: 1286669) Hochstrasser D.F. … Hughes G.J. (Electrophoresis 1992) 3 4
  4. Assignment of COX6A1 to 6p21 and a pseudogene (COX6A1P) to 1p31.1 by in situ hybridization and somatic cell hybrids. (PMID: 9284905) Hey Y. … Varley J.M. (Cytogenet. Cell Genet. 1997) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for COX6A1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate COX6A1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for COX6A1
    • Block miRNA regulation of COX6A1 using miScript Target Protectors

    Sources for COX6A1 Gene

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