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Aliases for COX5B Gene

Aliases for COX5B Gene

  • Cytochrome C Oxidase Subunit Vb 2 3
  • Cytochrome C Oxidase Polypeptide VB, Mitochondrial 3
  • Cytochrome C Oxidase Subunit 5B, Mitochondrial 3
  • Cytochrome C Oxidase Polypeptide Vb 4
  • COXVB 3

External Ids for COX5B Gene

Summaries for COX5B Gene

Entrez Gene Summary for COX5B Gene

  • Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme. [provided by RefSeq, Jul 2008]

GeneCards Summary for COX5B Gene

COX5B (Cytochrome C Oxidase Subunit Vb) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include cytochrome-c oxidase activity.

UniProtKB/Swiss-Prot for COX5B Gene

  • This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Gene Wiki entry for COX5B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX5B Gene

Genomics for COX5B Gene

Genomic Location for COX5B Gene

Start:
97,646,040 bp from pter
End:
97,648,383 bp from pter
Size:
2,344 bases
Orientation:
Plus strand

Genomic View for COX5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COX5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX5B Gene

Regulatory Elements for COX5B Gene

Proteins for COX5B Gene

  • Protein details for COX5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10606-COX5B_HUMAN
    Recommended name:
    Cytochrome c oxidase subunit 5B, mitochondrial
    Protein Accession:
    P10606
    Secondary Accessions:
    • Q53YB7
    • Q96J18
    • Q99610

    Protein attributes for COX5B Gene

    Size:
    129 amino acids
    Molecular mass:
    13696 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX5B Gene

Proteomics data for COX5B Gene at MOPED

Post-translational modifications for COX5B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys57, Lys68, and Lys86

Other Protein References for COX5B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for COX5B Gene

Domains for COX5B Gene

Gene Families for COX5B Gene

HGNC:
  • comIV :Mitochondrial respiratory chain complex / Complex IV

Protein Domains for COX5B Gene

Suggested Antigen Peptide Sequences for COX5B Gene

Graphical View of Domain Structure for InterPro Entry

P10606

UniProtKB/Swiss-Prot:

COX5B_HUMAN
Family:
  • Belongs to the cytochrome c oxidase subunit 5B family.:
    • P10606
genes like me logo Genes that share domains with COX5B: view

Function for COX5B Gene

Molecular function for COX5B Gene

GENATLAS Biochemistry: cytochrome c oxidase,subunit Vb,component of the complex IV,terminal enzyme complex for electron transfert,oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Gene Ontology (GO) - Molecular Function for COX5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 cytochrome-c oxidase activity IEA --
GO:0005515 protein binding IPI 21516116
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with COX5B: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for COX5B Gene

Localization for COX5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX5B Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COX5B Gene COMPARTMENTS Subcellular localization image for COX5B gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for COX5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005740 mitochondrial envelope --
GO:0005743 mitochondrial inner membrane TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with COX5B: view

Pathways for COX5B Gene

genes like me logo Genes that share pathways with COX5B: view

Gene Ontology (GO) - Biological Process for COX5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007585 respiratory gaseous exchange TAS 1646156
GO:0010467 gene expression TAS --
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
genes like me logo Genes that share ontologies with COX5B: view

Compounds for COX5B Gene

(2) HMDB Compounds for COX5B Gene

Compound Synonyms Cas Number PubMed IDs
Oxygen
  • Oxygen
7782-44-7
Water
  • Dihydrogen oxide
7732-18-5

(2) Drugbank Compounds for COX5B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cholic Acid
81-25-4 target
N-Formylmethionine
target
genes like me logo Genes that share compounds with COX5B: view

Transcripts for COX5B Gene

mRNA/cDNA for COX5B Gene

Unigene Clusters for COX5B Gene

Cytochrome c oxidase subunit Vb:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COX5B Gene

No ASD Table

Relevant External Links for COX5B Gene

GeneLoc Exon Structure for
COX5B
ECgene alternative splicing isoforms for
COX5B

Expression for COX5B Gene

mRNA expression in normal human tissues for COX5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COX5B Gene

This gene is overexpressed in Heart - Left Ventricle (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COX5B Gene

SOURCE GeneReport for Unigene cluster for COX5B Gene Hs.1342

genes like me logo Genes that share expressions with COX5B: view

No data available for mRNA Expression by UniProt/SwissProt for COX5B Gene

Orthologs for COX5B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for COX5B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COX5B 36
  • 97 (a)
OneToOne
LOC741789 35
  • 98.97 (n)
  • 96.9 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 55 (a)
OneToMany
COX5B 35
  • 85.53 (n)
  • 82.95 (a)
COX5B 36
  • 83 (a)
OneToMany
dog
(Canis familiaris)
Mammalia COX5B 35
  • 76.96 (n)
  • 69.92 (a)
COX5B 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cox5b 16
Cox5b 36
  • 84 (a)
OneToMany
Gm11273 36
  • 84 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia COX5B 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COX5B 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cox5b 35
  • 82.69 (n)
  • 81.4 (a)
lizard
(Anolis carolinensis)
Reptilia COX5B 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cox5b.2 35
  • 58.47 (n)
  • 59.32 (a)
Str.6748 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.306 35
zebrafish
(Danio rerio)
Actinopterygii COX5B (1 of 3) 36
  • 62 (a)
OneToMany
COX5B (2 of 3) 36
  • 63 (a)
OneToMany
cox5b2 36
  • 43 (a)
OneToMany
hmzeh0438 35
LOC100002384 35
  • 62.73 (n)
  • 66.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta CoVb 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cco-1 36
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COX4 38
Species with no ortholog for COX5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COX5B Gene

ENSEMBL:
Gene Tree for COX5B (if available)
TreeFam:
Gene Tree for COX5B (if available)

Paralogs for COX5B Gene

genes like me logo Genes that share paralogs with COX5B: view

No data available for Paralogs for COX5B Gene

Variants for COX5B Gene

Sequence variations from dbSNP and Humsavar for COX5B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1800648 -- 97,645,331(-) ACATA(C/T)TCCGT upstream-variant-2KB
rs1800649 -- 97,648,394(+) AGGGG(C/T)GGGCT downstream-variant-500B
rs2071038 -- 97,645,173(+) ATTCA(A/G)TGATG upstream-variant-2KB
rs4851347 -- 97,644,917(+) attGG(G/T)GGAGG upstream-variant-2KB
rs5832840 -- 97,644,892(+) CAGGG(-/T)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for COX5B Gene

Variant ID Type Subtype PubMed ID
esv718 CNV CNV 17122850
nsv522486 CNV Gain 19592680
essv18990 CNV CNV 17122850
essv17999 CNV CNV 17122850

Relevant External Links for COX5B Gene

HapMap Linkage Disequilibrium report
COX5B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX5B Gene

Disorders for COX5B Gene

Relevant External Links for COX5B

Genetic Association Database (GAD)
COX5B
Human Genome Epidemiology (HuGE) Navigator
COX5B
genes like me logo Genes that share disorders with COX5B: view

No data available for UniProtKB/Swiss-Prot for COX5B Gene

Publications for COX5B Gene

  1. Structure of the human cytochrome c oxidase subunit Vb gene and chromosomal mapping of the coding gene and of seven pseudogenes. (PMID: 1646156) Lomax M.I. … Francke U. (Genomics 1991) 3 4 23
  2. Phylogenetic footprinting of the human cytochrome c oxidase subunit VB promoter. (PMID: 8806766) Bachman N.J. … Lomax M.I. (Arch. Biochem. Biophys. 1996) 3 4 23
  3. Cytochrome c oxidase subunit Vb interacts with human androgen receptor: a potential mechanism for neurotoxicity in spinobulbar muscular atrophy. (PMID: 11719263) Beauchemin A.M. … Trifiro M.A. (Brain Res. Bull. 2001) 3 23
  4. Sequence of cDNAs encoding subunit Vb of human and bovine cytochrome c oxidase. (PMID: 2840351) Zeviani M. … Schon E.A. (Gene 1988) 3 4
  5. Human liver protein map: update 1993. (PMID: 8313870) Hughes G.J. … Hochstrasser D.F. (Electrophoresis 1993) 3 4

Products for COX5B Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Mitochondrial Energy Metabolism in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate COX5B
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for COX5B
    • Block miRNA regulation of COX5B using miScript Target Protectors

    Sources for COX5B Gene

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