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Aliases for COX5B Gene

Aliases for COX5B Gene

  • Cytochrome C Oxidase Subunit 5B 2 3
  • Cytochrome C Oxidase Subunit Vb 2 3 5
  • Cytochrome C Oxidase Polypeptide VB, Mitochondrial 3
  • Cytochrome C Oxidase Polypeptide Vb 4
  • COXVB 3

External Ids for COX5B Gene

Previous GeneCards Identifiers for COX5B Gene

  • GC02P096143
  • GC02P096715
  • GC02P097867
  • GC02P097883
  • GC02P097721
  • GC02P098262
  • GC02P092031

Summaries for COX5B Gene

Entrez Gene Summary for COX5B Gene

  • Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme. [provided by RefSeq, Jul 2008]

GeneCards Summary for COX5B Gene

COX5B (Cytochrome C Oxidase Subunit 5B) is a Protein Coding gene. Among its related pathways are Gene Expression and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include cytochrome-c oxidase activity.

UniProtKB/Swiss-Prot for COX5B Gene

  • This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Gene Wiki entry for COX5B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX5B Gene

Genomics for COX5B Gene

Regulatory Elements for COX5B Gene

Enhancers for COX5B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around COX5B on UCSC Golden Path with GeneCards custom track

Promoters for COX5B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COX5B on UCSC Golden Path with GeneCards custom track

Genomic Location for COX5B Gene

97,646,040 bp from pter
97,648,383 bp from pter
2,344 bases
Plus strand

Genomic View for COX5B Gene

Genes around COX5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX5B Gene

Proteins for COX5B Gene

  • Protein details for COX5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome c oxidase subunit 5B, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q53YB7
    • Q96J18
    • Q99610

    Protein attributes for COX5B Gene

    129 amino acids
    Molecular mass:
    13696 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX5B Gene

Proteomics data for COX5B Gene at MOPED

Post-translational modifications for COX5B Gene

  • Ubiquitination at Lys 57, Lys 68, and Lys 86
  • Modification sites at PhosphoSitePlus

Other Protein References for COX5B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COX5B Gene

Domains & Families for COX5B Gene

Protein Domains for COX5B Gene

Suggested Antigen Peptide Sequences for COX5B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytochrome c oxidase subunit 5B family.
  • Belongs to the cytochrome c oxidase subunit 5B family.
genes like me logo Genes that share domains with COX5B: view

Function for COX5B Gene

Molecular function for COX5B Gene

GENATLAS Biochemistry:
cytochrome c oxidase,subunit Vb,component of the complex IV,terminal enzyme complex for electron transfert,oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
genes like me logo Genes that share phenotypes with COX5B: view

Animal Model Products

miRNA for COX5B Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COX5B Gene

Localization for COX5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX5B Gene

Mitochondrion inner membrane.

Subcellular locations from

Jensen Localization Image for COX5B Gene COMPARTMENTS Subcellular localization image for COX5B gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for COX5B Gene

Pathways & Interactions for COX5B Gene

genes like me logo Genes that share pathways with COX5B: view

Gene Ontology (GO) - Biological Process for COX5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:1902600 hydrogen ion transmembrane transport TAS 1646156
genes like me logo Genes that share ontologies with COX5B: view

No data available for SIGNOR curated interactions for COX5B Gene

Drugs & Compounds for COX5B Gene

(2) Drugs for COX5B Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cholic acid Approved Pharma Full agonist, Agonist, Target 0
N-Formylmethionine Experimental Pharma Target 0

(2) Additional Compounds for COX5B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with COX5B: view

Transcripts for COX5B Gene

mRNA/cDNA for COX5B Gene

Unigene Clusters for COX5B Gene

Cytochrome c oxidase subunit Vb:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COX5B Gene

No ASD Table

Relevant External Links for COX5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COX5B Gene

mRNA expression in normal human tissues for COX5B Gene

mRNA differential expression in normal tissues according to GTEx for COX5B Gene

This gene is overexpressed in Heart - Left Ventricle (x4.0).

Protein differential expression in normal tissues from HIPED for COX5B Gene

This gene is overexpressed in Nasal epithelium (44.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COX5B Gene

SOURCE GeneReport for Unigene cluster for COX5B Gene Hs.1342

genes like me logo Genes that share expression patterns with COX5B: view

Protein tissue co-expression partners for COX5B Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for COX5B Gene

Orthologs for COX5B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for COX5B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia COX5B 35
  • 85.53 (n)
  • 82.95 (a)
-- 36
  • 55 (a)
COX5B 36
  • 83 (a)
(Canis familiaris)
Mammalia COX5B 35
  • 76.96 (n)
  • 69.92 (a)
COX5B 36
  • 84 (a)
(Pan troglodytes)
Mammalia LOC741789 35
  • 98.97 (n)
  • 96.9 (a)
COX5B 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Cox5b 35
  • 82.69 (n)
  • 81.4 (a)
(Monodelphis domestica)
Mammalia COX5B 36
  • 79 (a)
(Mus musculus)
Mammalia Cox5b 36
  • 84 (a)
Gm11273 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia COX5B 36
  • 83 (a)
(Anolis carolinensis)
Reptilia COX5B 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cox5b.2 35
  • 58.47 (n)
  • 59.32 (a)
Str.6748 35
(Danio rerio)
Actinopterygii hmzeh0438 35
LOC100002384 35
  • 62.73 (n)
  • 66.14 (a)
COX5B (1 of 3) 36
  • 62 (a)
COX5B (2 of 3) 36
  • 63 (a)
cox5b2 36
  • 43 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.306 35
fruit fly
(Drosophila melanogaster)
Insecta CoVb 36
  • 34 (a)
(Caenorhabditis elegans)
Secernentea cco-1 36
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COX4 38
Species with no ortholog for COX5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COX5B Gene

Gene Tree for COX5B (if available)
Gene Tree for COX5B (if available)

Paralogs for COX5B Gene

genes like me logo Genes that share paralogs with COX5B: view

No data available for Paralogs for COX5B Gene

Variants for COX5B Gene

Sequence variations from dbSNP and Humsavar for COX5B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1800648 -- 97,645,331(-) ACATA(C/T)TCCGT upstream-variant-2KB
rs1800649 -- 97,648,394(+) AGGGG(C/T)GGGCT downstream-variant-500B
rs2071038 -- 97,645,173(+) ATTCA(A/G)TGATG upstream-variant-2KB
rs5832840 -- 97,644,892(+) CAGGG(-/T)TTTTT upstream-variant-2KB
rs11695635 -- 97,646,473(+) CTTCA(A/C)ACCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COX5B Gene

Variant ID Type Subtype PubMed ID
esv718 CNV CNV 17122850
nsv522486 CNV Gain 19592680
essv18990 CNV CNV 17122850
essv17999 CNV CNV 17122850

Variation tolerance for COX5B Gene

Residual Variation Intolerance Score: 69.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.23% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for COX5B Gene

Disorders for COX5B Gene

Relevant External Links for COX5B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for COX5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX5B Gene

Publications for COX5B Gene

  1. Phylogenetic footprinting of the human cytochrome c oxidase subunit VB promoter. (PMID: 8806766) Bachman N.J. … Lomax M.I. (Arch. Biochem. Biophys. 1996) 3 4 23 67
  2. Cytochrome c oxidase subunit Vb interacts with human androgen receptor: a potential mechanism for neurotoxicity in spinobulbar muscular atrophy. (PMID: 11719263) Beauchemin A.M. … Trifiro M.A. (Brain Res. Bull. 2001) 3 23
  3. The Protein Data Bank. (PMID: 10592235) Berman H.M. … Bourne P.E. (Nucleic Acids Res. 2000) 25 26
  4. Structure of the human cytochrome c oxidase subunit Vb gene and chromosomal mapping of the coding gene and of seven pseudogenes. (PMID: 1646156) Lomax M.I. … Francke U. (Genomics 1991) 3 23
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for COX5B Gene

Sources for COX5B Gene