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COX5B Gene

protein-coding   GIFtS: 61
GCID: GC02P098262

Cytochrome C Oxidase Subunit Vb

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome C Oxidase Subunit Vb1 2
COXVB2
Cytochrome C Oxidase Polypeptide VB, Mitochondrial2
Cytochrome C Oxidase Subunit 5B, Mitochondrial2
Cytochrome C Oxidase Polypeptide Vb3

External Ids:    HGNC: 22691   Entrez Gene: 13292   Ensembl: ENSG000001359407   OMIM: 1238665   UniProtKB: P106063   

Export aliases for COX5B gene to outside databases

Previous GC identifers: GC02P096143 GC02P096715 GC02P097867 GC02P097883 GC02P097721 GC02P097628 GC02P092031


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COX5B Gene:
Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit
enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a
proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13
mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer
and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role
in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human
mitochondrial respiratory chain enzyme. (provided by RefSeq, Jul 2008)

GeneCards Summary for COX5B Gene:
COX5B (cytochrome c oxidase subunit Vb) is a protein-coding gene. Diseases associated with COX5B include muscular atrophy, and huntington's disease. GO annotations related to this gene include cytochrome-c oxidase activity.

UniProtKB/Swiss-Prot: COX5B_HUMAN, P10606
Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal
oxidase in mitochondrial electron transport

Gene Wiki entry for COX5B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the COX5B gene promoter:
         GR   RFX1   AML1a   p53   SREBP-1c   SREBP-1b   C/EBPalpha   SREBP-1a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOX5B promoter sequence
   Search Chromatin IP Primers for COX5B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COX5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2

COX5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COX5B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P098262:  view genomic region     (about GC identifiers)

Start:
98,262,503 bp from pter      End:
98,264,846 bp from pter
Size:
2,344 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: COX5B_HUMAN, P10606 (See protein sequence)
Recommended Name: Cytochrome c oxidase subunit 5B, mitochondrial precursor  
Size: 129 amino acids; 13696 Da
Secondary accessions: Q53YB7 Q96J18 Q99610

Explore the universe of human proteins at neXtProt for COX5B: NX_P10606

Explore proteomics data for COX5B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys57, Lys68, Lys86
  • Modification sites at PhosphoSitePlus

  • See COX5B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001853.2  
    ENSEMBL proteins: 
     ENSP00000258424  
    Reactome Protein details: P10606

    COX5B Human Recombinant Protein Products:

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    COX5B Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    comIV: Mitochondrial respiratory chain complex / Complex IV

    2 InterPro protein domains:
     IPR002124 Cyt_c_oxidase_su5b
     IPR020893 Cyt_c_oxidase_su5b_Zn_BS

    Graphical View of Domain Structure for InterPro Entry P10606

    ProtoNet protein and cluster: P10606

    1 Blocks protein domain: IPB002124 Cytochrome c oxidase

    UniProtKB/Swiss-Prot: COX5B_HUMAN, P10606
    Similarity: Belongs to the cytochrome c oxidase subunit 5B family


    COX5B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COX5B_HUMAN, P10606
    Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal
    oxidase in mitochondrial electron transport

         Genatlas biochemistry entry for COX5B:
    cytochrome c oxidase,subunit Vb,component of the complex IV,terminal enzyme complex for electron
    transfert,oxidative phosphorylation (OXPHOS),inner mitochondrial membrane

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004129cytochrome-c oxidase activity IEA--
    GO:0046872metal ion binding IEA--
         
    COX5B for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COX5B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for COX5B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COX5B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COX5B

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for COX5B
    Predesigned siRNA for gene silencing in human, mouse, rat COX5B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for COX5B

    Clone
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    OriGene clones in human, mouse for COX5B (see all 6)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COX5B (NM_001862)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COX5B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX5B

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for COX5B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX5B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COX5B_HUMAN, P10606: Mitochondrion inner membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    nucleus2
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005740mitochondrial envelope ----
    GO:0005743mitochondrial inner membrane TAS--

    COX5B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for COX5B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Oxidative phosphorylation0.64
    Respiratory electron transport0.81
    Parkinson's disease0.57
    Electron Transport Chain0.75
    Huntington's disease0.45
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Alzheimer's disease
    Alzheimer's disease0.44
    4Cardiac muscle contraction
    Cardiac muscle contraction
    5AMPK Enzyme Complex Pathway
    AMPK Enzyme Complex Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for COX5B
        AMPK Enzyme Complex Pathway

    1 BioSystems Pathway for COX5B
        Electron Transport Chain


    1 Reactome Pathway for COX5B
        Respiratory electron transport


    Selected Kegg Pathways  (Kegg details for COX5B) (see all 7):
        Oxidative phosphorylation
    Metabolic pathways
    Cardiac muscle contraction
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease


    COX5B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including COX5B: 
              Mitochondrial Energy Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for COX5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COX5B (P106063 ENSP000002584244) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102753, ENSP000003638224I2D: score=2 STRING: ENSP00000363822
    MT-CO2P004033, ENSP000003548764I2D: score=1 STRING: ENSP00000354876
    NELFCDQ8IXH73, ENSP000003423004I2D: score=1 STRING: ENSP00000342300
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    EPB41P111713, ENSP000002901004I2D: score=1 STRING: ENSP00000290100
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007585respiratory gaseous exchange TAS1646156
    GO:0022904respiratory electron transport chain TAS--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:1902600hydrogen ion transmembrane transport TAS1646156

    COX5B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COX5B

    2 HMDB Compounds for COX5B    About this table
    CompoundSynonyms CAS #PubMed Ids
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for COX5B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cholic Acid-- 81-25-4target--10592235
    N-Formylmethionine-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for COX5B gene: 
    NM_001862.2  

    Unigene Cluster for COX5B:

    Cytochrome c oxidase subunit Vb
    Hs.1342  [show with all ESTs]
    Unigene Representative Sequence: BM912880
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258424(uc002sya.3) ENST00000464949 ENST00000491989 ENST00000494306


    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat COX5B
    Clone
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    GenScript: all cDNA clones in your preferred vector: COX5B (NM_001862)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COX5B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX5B
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat COX5B
      QuantiTect SYBR Green Assays in human, mouse, rat COX5B
      QuantiFast Probe-based Assays in human, mouse, rat COX5B

    Additional mRNA sequence: 

    BC006229.2 BT006742.1 CR541727.1 CR541753.1 M19961.1 

    10 DOTS entries:

    DT.454189  DT.100039507  DT.92443997  DT.450291  DT.100656116  DT.95096640  DT.120996675  DT.87011031 
    DT.91897520  DT.101955749 

    Selected AceView cDNA sequences (see all 309):

    BQ639825 BF061790 AV708579 CB110753 BM768285 BQ682165 BM695447 F21060 
    BM053123 H22326 F28517 AJ573361 F32100 BQ100825 F19426 BM767022 
    CD108860 BP871226 BE732327 AW298397 AI720111 BM893592 AA328732 BM128304 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COX5B expression in normal human tissues (normalized intensities)      COX5B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCTGCAA
    COX5B Expression
    About this image


    COX5B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
     
     Kidney (Urinary System)
             Metanephros
     
     Neural Tube (Nervous System)
             Telencephalon
    COX5B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COX5B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1342
        Pathway & Disease-focused RT2 Profiler PCR Array including COX5B: 
              Mitochondrial Energy Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX5B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for COX5B gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cox5b5 cytochrome c oxidase, subunit Vb   --   1 (15.38 cM) 36691487 
    lizard
    (Anolis carolinensis)
    Reptilia COX5B6
    cytochrome c oxidase subunit Vb
    58(a)
    1 ↔ 1
    GL343484.1(143718-145720)
    African clawed frog
    (Xenopus laevis)
    Amphibia BI350167.12   -- 74.5(n)    BI350167.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hmzeh04382 hmzeh0438 76.28(n)   321396  57095569 
    fruit fly
    (Drosophila melanogaster)
    Insecta CoVb6
    Cytochrome c oxidase subunit Vb
    34(a)
    1 ↔ 1
    2L(6557800-6559308)
    worm
    (Caenorhabditis elegans)
    Secernentea cco-16
    Protein CCO-1 (cco-1) mRNA, complete cds
    28(a)
    1 ↔ 1
    I(9788749-9789965) WBGene00000371


    ENSEMBL Gene Tree for COX5B (if available)
    TreeFam Gene Tree for COX5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for COX5B gene

    COX5B for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for COX5B (see all 8)
    PGOHUM00000242385 PGOHUM00000239772 PGOHUM00000248486 PGOHUM00000245102 PGOHUM00000246333


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COX5B (see all 84)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs774687551,2
    C,F--98260539(+) TGAGGG/AACTGG 1 -- us2k13Minor allele frequency- A:0.05NA WA 240
    rs1825389021,2
    --98260604(+) GGGAGA/CCTGGA 1 -- us2k10--------
    rs1455295011,2
    --98260733(+) GAGAAA/GCCTAA 1 -- us2k10--------
    rs770434081,2
    F--98260801(+) CATAAC/GATATC 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs591683501,2
    C,F--98261002(+) GCAGGC/ACCTCC 1 -- us2k13Minor allele frequency- A:0.10WA EA 240
    rs1381309711,2
    --98261091(+) CCTAGC/TTGAAC 1 -- us2k10--------
    rs577773771,2
    C--98261373(+) TTTTT-/T/TT  
            
    AATTG
    1 -- us2k11NA 2
    rs1877184161,2
    --98261425(+) GCAACG/TCTCCA 1 -- us2k10--------
    rs1908058311,2
    --98261471(+) ACAGGC/TGGGAG 1 -- us2k10--------
    rs1160931001,2
    C,F--98261495(+) AACTCT/GCCCCA 1 -- us2k11Minor allele frequency- G:0.08NA 120

    HapMap Linkage Disequilibrium report for COX5B (98262503 - 98264846 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for COX5B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv522486CNV Gain19592680
    essv17999CNV CNV17122850
    esv718CNV CNV17122850
    essv18990CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COX5B
    DNA2.0 Custom Variant and Variant Library Synthesis for COX5B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 123866    OMIM disorders: --

    15 diseases for COX5B:    About MalaCards
    muscular atrophy    huntington's disease    fatty liver disease    tonsillitis
    parkinson's disease    lung adenocarcinoma    liver disease    alzheimer's disease
    hypertension    hiv-1    cerebritis    thyroiditis
    adenocarcinoma    endotheliitis    prostatitis


    COX5B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): COX5B
    Human Genome Epidemiology (HuGE) Navigator: COX5B (3 documents)

    Export disorders for COX5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COX5B gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with COX5B)
        Utopia: connect your pdf to the dynamic
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    1. Phylogenetic footprinting of the human cytochrome c oxidase subunit VB promoter. (PubMed id 8806766)1, 2, 9 Bachman N.J.... Lomax M.I. (Arch. Biochem. Biophys. 1996)
    2. Structure of the human cytochrome c oxidase subunit Vb gene and chromosomal mapping of the coding gene and of seven pseudogenes. (PubMed id 1646156)1, 2, 9 Lomax M.I.... Francke U. (Genomics 1991)
    3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Human liver protein map: update 1993. (PubMed id 8313870)1, 2 Hughes G.J.... Hochstrasser D.F. (Electrophoresis 1993)
    8. Sequence of cDNAs encoding subunit Vb of human and bovine cytochrome c oxidase. (PubMed id 2840351)1, 2 Zeviani M.... Schon E.A. (Gene 1988)
    9. Cytochrome c oxidase subunit Vb interacts with human androgen receptor: a potential mechanism for neurotoxicity in spinobulbar muscular atrophy. (PubMed id 11719263)1, 9 Beauchemin A.M....Trifiro M.A. (Brain Res. Bull. 2001)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1329 HGNC: 2269 AceView: COX5B Ensembl:ENSG00000135940 euGenes: HUgn1329
    ECgene: COX5B Kegg: 1329 H-InvDB: COX5B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for COX5B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for COX5B gene:
    Search GeneIP for patents involving COX5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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