COX5B Gene
protein-coding GIFtS: 56
GCID: GC02P098262
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cytochrome c oxidase subunit Vb
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Aliases
for COX5B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cytochrome C Oxidase Subunit Vb1 2 | | COXVB2 | | Cytochrome C Oxidase Polypeptide VB, Mitochondrial2 | | Cytochrome C Oxidase Subunit 5B, Mitochondrial2 | | Cytochrome C Oxidase Polypeptide Vb3 |
Export aliases for COX5B gene to outside databasesPrevious GC identifers: GC02P096143 GC02P096715 GC02P097867 GC02P097883 GC02P097721 GC02P097628 GC02P092031 |
Summaries
for COX5B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for COX5B:
Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzymecomplex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a protonelectrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- andnuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumpingactivities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation andassembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chainenzyme. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: COX5B_HUMAN, P10606Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase inmitochondrial electron transport
Gene Wiki entry for COX5B
|
Genomic Views
for COX5B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022171.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the COX5B gene promoter:
GR RFX1 AML1a p53 SREBP-1c SREBP-1b C/EBPalpha SREBP-1a GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for COX5B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COX5B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q11.2 Ensembl cytogenetic band: 2q11.2 HGNC cytogenetic band: 2q11.2COX5B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P098262: view genomic region
(about GC identifiers)
Start:
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98,262,503 bp from pter |
End:
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98,264,846 bp from pter |
Size:
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2,344 bases |
Orientation:
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plus strand |
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Proteins
for COX5B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: COX5B_HUMAN, P10606 (See
protein sequence)Recommended Name: Cytochrome c oxidase subunit 5B, mitochondrial precursor Size: 129 amino acids; 13696 Da
Subcellular location: Mitochondrion inner membrane
Secondary accessions: Q53YB7 Q96J18 Q99610Explore the universe of human proteins at neXtProt for COX5B: NX_P10606
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P10606
COX5B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001853.2
ENSEMBL proteins: ENSP00000258424 Reactome Protein details: P10606
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IDA | -- | | GO:0005743 | mitochondrial inner membrane |
TAS | -- |
COX5B for ontologies About GeneDecksing
COX5B Antibody Products:
Assay Products for COX5B: |
Protein
Domains /
Families
for COX5B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
COX5B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P10606ProtoNet protein and cluster: P10606 1 Blocks protein family: IPB002124 Cytochrome c oxidase
UniProtKB/Swiss-Prot: COX5B_HUMAN, P10606Similarity: Belongs to the cytochrome c oxidase subunit 5B family |
Function
for COX5B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: COX5B_HUMAN, P10606Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase inmitochondrial electron transport Genatlas biochemistry entry for COX5B:cytochrome c oxidase,subunit Vb,component of the complex IV,terminal enzyme complex for electron transfert,oxidativephosphorylation (OXPHOS),inner mitochondrial membrane
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COX5B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COX5B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for COX5B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX5B |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004129 | cytochrome-c oxidase activity |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
COX5B for ontologies About GeneDecksing
|
Pathways & Interactions
for COX5B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 2 | Metabolism | | | 3 | AMPK Enzyme Complex Pathway | | | 4 | Cardiac muscle contraction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for COX5B
1  BioSystems Pathway for COX5B
4 
Reactome Pathways for COX5B
5/6 
Kegg Pathways (Kegg details for COX5B) (see all 6):
COX5B for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for COX5B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/42 Interacting proteins for COX5B (P106063 ENSP000002584244) via UniProtKB, MINT, STRING, and/or I2D (see all 42)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007585 | respiratory gaseous exchange |
TAS | 1646156 | | GO:0022904 | respiratory electron transport chain |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
COX5B for ontologies About GeneDecksing
|
Drugs & Compounds
for COX5B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for COX5B
2 HMDB Compounds for COX5B About this table
2 DrugBank Compounds for COX5B About this table
Search CenterWatch for drugs/clinical trials and news about COX5B
|
Transcripts
for COX5B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for COX5B gene: NM_001862.2 Unigene Cluster for COX5B: Cytochrome c oxidase subunit Vb Hs.1342 [show with all ESTs]Unigene Representative Sequence: BM9128804 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000258424(uc002sya.3) ENST00000464949 ENST00000491989 ENST00000494306
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COX5B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COX5B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: COX5B (NM_001862) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COX5B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX5B |
Additional cDNA sequence: BC006229.2 BT006742.1 CR541727.1 CR541753.1 M19961.1 10 DOTS entries: DT.454189 DT.100039507 DT.92443997 DT.450291 DT.100656116 DT.95096640 DT.120996675 DT.87011031 DT.91897520 DT.101955749 24/309 AceView cDNA sequences (see all 309): BM053123 BP871226 CK905072 F31291 F28517 AI160480 NM_001862 BQ681373 BQ673579 AJ573361 BQ639825 BE732327 AA335872 F34072 BQ101124 H22326 BQ686303 BM893631 F33866 BC006229 BU163033 BM768285 CB110753 AV708579
GeneLoc Exon Structure
|
Expression
for COX5B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| COX5B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGCTGCAA
About this image
See COX5B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COX5B
SOURCE GeneReport for Unigene cluster: Hs.1342
SABiosciences Expression via Pathway-Focused PCR Array including COX5B: | Mitochondrial Energy Metabolism in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COX5B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat COX5B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COX5B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COX5B |
Orthologs
for COX5B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for COX5B gene from 8/23 species (see all 23) About this table
ENSEMBL Gene Tree for COX5B (if available)
TreeFam Gene Tree for COX5B (if available) |
Paralogs
for COX5B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for COX5B gene
COX5B for paralogs About GeneDecksing
5/8 Pseudogenes.org Pseudogenes for COX5B (see all 8)
PGOHUM00000242385 PGOHUM00000239772 PGOHUM00000248486 PGOHUM00000245102 PGOHUM00000246333
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Genomic Variants
for COX5B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for COX5B (98262503 - 98264846 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for COX5B
2 CNVs: 3378 2402 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COX5B |
|
Disorders
/ Diseases
for COX5B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
COX5B for disorders About GeneDecksing
OMIM gene information: 123866
OMIM disorders: --
4  diseases for COX5B: About MalaCardsmuscular atrophy huntington's disease parkinson's disease colon cancer
Human Genome Epidemiology (HuGE) Navigator: COX5B (3 documents)
Export disorders for COX5B gene to outside databases
|
Publications
for COX5B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for COX5B gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with COX5B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Phylogenetic footprinting of the human cytochrome c oxidase subunit VB promoter. (PubMed id 8806766)1, 2, 9 Bachman N.J.... Lomax M.I. (1996)
- Structure of the human cytochrome c oxidase subunit Vb gene and chromosomal mapping of the coding gene and of seven pseudogenes. (PubMed id 1646156)1, 2, 9 Lomax M.I.... Francke U. (1991)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human liver protein map: update 1993. (PubMed id 8313870)1, 2 Hughes G.J.... Hochstrasser D.F. (1993)
- Sequence of cDNAs encoding subunit Vb of human and bovine cytochrome c oxidase. (PubMed id 2840351)1, 2 Zeviani M.... Schon E.A. (1988)
- Cytochrome c oxidase subunit Vb interacts with human androgen receptor: a potential mechanism for neurotoxicity in spinobulbar muscular atrophy. (PubMed id 11719263)1, 9 Beauchemin A.M....Trifiro M.A. (2001)
- HIV-1 Tat protein directly induces mitochondrial membr ane permeabilization and inactivates cytochrome c oxidase. (PubMed id 22419111)1 Lecoeur H....Jacotot E. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for COX5B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing COX5B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing COX5B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COX5B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for COX5B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for COX5B gene:
Search GeneIP for patents involving COX5B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for COX5B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for COX5B | | OriGene shRNA RFP for COX5B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COX5B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COX5B | | | OriGene Protein Over-expression Lysate for COX5B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for COX5B | | OriGene 3'-UTR Clone for COX5B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COX5B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COX5B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for COX5B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for COX5B | | OriGene Custom Protein Services for COX5B | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COX5B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COX5B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COX5B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COX5B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COX5B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COX5B |
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 |  |  |  | |
| | | | Search Tocris compounds for COX5B |
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 | | | COX5B Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for COX5B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX5B |
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