Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



COX5A Gene

protein-coding   GIFtS: 64
GCID: GC15M075212

Cytochrome C Oxidase Subunit Va

  See COX5A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cytochrome C Oxidase Subunit Va1 2     VA2
Cytochrome C Oxidase Polypeptide Va2 3     Cytochrome C Oxidase Polypeptide, Mitochondrial2
COX2     Cytochrome C Oxidase Subunit 5A, Mitochondrial2
COX-VA2     Mitochondrial Cytochrome C Oxidase Subunit Va2

External Ids:    HGNC: 22671   Entrez Gene: 93772   Ensembl: ENSG000001787417   OMIM: 6037735   UniProtKB: P206743   

Export aliases for COX5A gene to outside databases

Previous GC identifers: GC15M071071 GC15M068327 GC15M072788 GC15M072928 GC15M072999 GC15M052009


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for COX5A Gene:
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit
enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a
proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13
mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer
of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role
in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Va of the human
mitochondrial respiratory chain enzyme. A pseudogene COX5AP1 has been found in chromosome 14q22. (provided by
RefSeq, Jul 2008)

GeneCards Summary for COX5A Gene:
COX5A (cytochrome c oxidase subunit Va) is a protein-coding gene. Diseases associated with COX5A include leukocoria, and acquired idiopathic sideroblastic anemia. GO annotations related to this gene include electron carrier activity and cytochrome-c oxidase activity.

UniProtKB/Swiss-Prot: COX5A_HUMAN, P20674
Function: This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial
electron transport




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the COX5A gene promoter:
         Max1   Spz1   p53   AP-1   ATF-2   NF-kappaB   c-Jun   NF-kappaB1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOX5A promoter sequence
   Search Chromatin IP Primers for COX5A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COX5A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.1   Ensembl cytogenetic band:  15q24.2   HGNC cytogenetic band: 15q25

COX5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COX5A gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M075212:  view genomic region     (about GC identifiers)

Start:
75,212,132 bp from pter      End:
75,230,509 bp from pter
Size:
18,378 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: COX5A_HUMAN, P20674 (See protein sequence)
Recommended Name: Cytochrome c oxidase subunit 5A, mitochondrial precursor  
Size: 150 amino acids; 16762 Da
Secondary accessions: P30045 Q8TB65

Explore the universe of human proteins at neXtProt for COX5A: NX_P20674

Explore proteomics data for COX5A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys62
  • Modification sites at PhosphoSitePlus

  • See COX5A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004246.2  
    ENSEMBL proteins: 
     ENSP00000317780   ENSP00000456253   ENSP00000457974   ENSP00000455053   ENSP00000456314  
     ENSP00000456386  
    Reactome Protein details: P20674

    COX5A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for COX5A
    OriGene Protein Over-expression Lysate for COX5A
    OriGene MassSpec for COX5A
    OriGene Custom Protein Services for COX5A
    GenScript Custom Purified and Recombinant Proteins Services for COX5A
    Novus Biologicals COX5A Proteins
    Novus Biologicals COX5A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for COX5A
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for COX5A 

    COX5A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for COX5A
    OriGene Custom Antibody Services for COX5A
    Novus Biologicals COX5A Antibodies
    Abcam antibodies for COX5A
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for COX5A
    LSBio Antibodies in human, mouse, rat for COX5A

    COX5A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for COX5A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for COX5A
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for COX5A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    comIV: Mitochondrial respiratory chain complex / Complex IV

    1 InterPro protein domain:
     IPR003204 Cyt_c_oxidase_su5A/6

    Graphical View of Domain Structure for InterPro Entry P20674

    ProtoNet protein and cluster: P20674

    1 Blocks protein domain: IPB003204 Cytochrome c oxidase

    UniProtKB/Swiss-Prot: COX5A_HUMAN, P20674
    Similarity: Belongs to the cytochrome c oxidase subunit 5A family


    Find genes that share domains with COX5A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COX5A_HUMAN, P20674
    Function: This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial
    electron transport

         Genatlas biochemistry entry for COX5A:
    cytochrome c oxidase,subunit Va,component of the complex IV,terminal enzyme complex for electron
    transfer,oxidative phosphorylation (OXPHOS),inner mitochondrial membrane

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004129cytochrome-c oxidase activity IEA--
    GO:0009055electron carrier activity TAS2853101
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with COX5A           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COX5A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for COX5A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COX5A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COX5A

    miRNA
    Products:
        
    miRTarBase miRNAs that target COX5A:
    hsa-mir-484 (MIRT042244), hsa-mir-20a-5p (MIRT050490), hsa-mir-324-5p (MIRT043091), hsa-mir-100-5p (MIRT048508)

    Block miRNA regulation of human, mouse, rat COX5A using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate COX5A:
    hsa-miR-3671 hsa-miR-562 hsa-miR-26a hsa-miR-26b hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidCOX5A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for COX5A
    Predesigned siRNA for gene silencing in human, mouse, rat COX5A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for COX5A

    Clone
    Products:
         
    OriGene clones in human, mouse for COX5A (see all 6)
    OriGene ORF clones in mouse, rat for COX5A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COX5A (NM_004255)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COX5A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX5A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for COX5A
    Browse ESI BIO Cell Lines and PureStem Progenitors for COX5A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX5A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    COX5A_HUMAN, P20674: Mitochondrion inner membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    extracellular2
    nucleus2
    plasma membrane2
    cytoskeleton1
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane TAS--

    Find genes that share ontologies with COX5A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for COX5A About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Oxidative phosphorylation0.64
    Respiratory electron transport0.81
    Parkinson's disease0.57
    Electron Transport Chain0.75
    Huntington's disease0.45
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Alzheimer's disease
    Alzheimer's disease0.44
    4Cardiac muscle contraction
    Cardiac muscle contraction
    5Arachidonate Epoxygenase / Epoxide Hydrolase
    Arachidonate Epoxygenase / Epoxide Hydrolase


    Find genes that share SuperPaths with COX5A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for COX5A
        AMPK Enzyme Complex Pathway

    2 BioSystems Pathways for COX5A
        Arachidonate Epoxygenase / Epoxide Hydrolase
    Electron Transport Chain

    1 Reactome Pathway for COX5A
        Respiratory electron transport


    Selected Kegg Pathways  (Kegg details for COX5A) (see all 7):
        Oxidative phosphorylation
    Metabolic pathways
    Cardiac muscle contraction
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease

        Pathway & Disease-focused RT2 Profiler PCR Arrays including COX5A: 
              Mitochondrial Energy Metabolism in human mouse rat
              Cancer PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for COX5A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COX5A (P206742, 3 ENSP000003177804) via UniProtKB, MINT, STRING, and/or I2D (see all 86)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL9P329693I2D: score=5 
    RPL9P7P329693I2D: score=5 
    RPL9P8P329693I2D: score=5 
    RPL9P9P329693I2D: score=5 
    COPS6Q7L5N12, 3, ENSP000003041024MINT-63552 I2D: score=5 STRING: ENSP00000304102
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0022904respiratory electron transport chain TAS--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:1902600hydrogen ion transmembrane transport TAS2853101

    Find genes that share ontologies with COX5A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COX5A

    3 HMDB Compounds for COX5A    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    Alpha-D-Glucose 1,6-bisphosphateAlpha-D-1,6-bis(dihydrogen phosphate) Glucopyranose (see all 15)10139-18-1--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--

    2 DrugBank Compounds for COX5A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cholic Acid-- 81-25-4target--10592235
    N-Formylmethionine-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for COX5A gene (see all 134)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arachidonic acid 86.6 285 12544904 (5), 16714329 (3), 16846782 (3), 7858842 (3) (see all 99)
    prostaglandin 84.5 150 19843975 (2), 11418589 (2), 8936582 (1), 9096394 (1) (see all 99)
    pge2 81 133 17868110 (6), 10815617 (4), 12002912 (3), 16714329 (3) (see all 71)
    celecoxib 78.8 15 15500394 (1), 12925310 (1), 19723114 (1), 10215599 (1) (see all 14)
    ns 398 75.8 9 19106979 (1), 12660005 (1), 15931672 (1), 17329938 (1) (see all 8)
    rofecoxib 74.3 12 16118328 (2), 17673806 (2), 12925310 (1), 15963707 (1) (see all 8)
    indomethacin 71 77 15224350 (2), 17880512 (2), 11352223 (2), 9831321 (2) (see all 60)
    prostaglandin-h2 70.5 13 9138698 (1), 9440135 (1), 16552393 (1), 12457435 (1) (see all 13)
    aspirin 70.3 81 14584890 (3), 17944992 (2), 16785401 (2), 15992053 (1) (see all 50)
    pgh2 69.4 9 9138698 (1), 14683687 (1), 15868626 (1), 12199620 (1) (see all 9)



    Find genes that share compounds with COX5A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for COX5A gene: 
    NM_004255.3  

    Unigene Cluster for COX5A:

    Cytochrome c oxidase subunit Va
    Hs.401903  [show with all ESTs]
    Unigene Representative Sequence: BU150928
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000322347(uc002azi.4) ENST00000562233 ENST00000567270 ENST00000568783
    ENST00000568517 ENST00000564811
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat COX5A using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate COX5A:
    hsa-miR-3671 hsa-miR-562 hsa-miR-26a hsa-miR-26b hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidCOX5A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for COX5A
    Predesigned siRNA for gene silencing in human, mouse, rat COX5A
    Clone
    Products:
         
    OriGene clones in human, mouse for COX5A (see all 6)
    OriGene ORF clones in mouse, rat for COX5A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COX5A (NM_004255)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COX5A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX5A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for COX5A
    OriGene qSTAR qPCR primer pairs in human, mouse for COX5A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COX5A
      QuantiTect SYBR Green Assays in human, mouse, rat COX5A
      QuantiFast Probe-based Assays in human, mouse, rat COX5A

    Additional mRNA sequence: 

    AK026615.1 AK026623.1 BC024240.2 CR407649.1 M22760.1 

    12 DOTS entries:

    DT.449524  DT.121026560  DT.100822512  DT.100822513  DT.120786733  DT.100822514  DT.92438976  DT.100822516 
    DT.40133167  DT.87015672  DT.91786142  DT.91960923 

    Selected AceView cDNA sequences (see all 358):

    BQ878734 AI184480 CB159146 AI804296 F30281 AW007839 BI521495 BQ427847 
    AI924773 AW054846 AI184908 BM695849 CK430601 BM821120 BG981120 N31071 
    BQ777070 BE256222 AW071860 BM272164 BU855496 F29691 BM666934 AI186196 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for COX5A    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b
    SP1:                    -                             -               
    SP2:                                                                  
    SP3:                    -                                             
    SP4:                    -           -     -     -     -               


    ECgene alternative splicing isoforms for COX5A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    COX5A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATGGTAAC
    COX5A Expression
    About this image


    COX5A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Thoracic Perivascular Adipose
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Kidney (Urinary System)
             Metanephros
    COX5A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COX5A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.401903
        Pathway & Disease-focused RT2 Profiler PCR Arrays including COX5A: 
              Mitochondrial Energy Metabolism in human mouse rat
              Cancer PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for COX5A
    OriGene qSTAR qPCR primer pairs in human, mouse for COX5A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COX5A
    QuantiTect SYBR Green Assays in human, mouse, rat COX5A
    QuantiFast Probe-based Assays in human, mouse, rat COX5A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX5A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for COX5A gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cox5a1 , 5 cytochrome c oxidase, subunit Va5
    cytochrome c oxidase subunit Va1
    87.9(n)1
    87.67(a)1
      9 (31.05 cM)5
    128581  NM_007747.21  NP_031773.21 
     575212325 
    chicken
    (Gallus gallus)
    Aves COX5A1 cytochrome c oxidase subunit Va 80.82(n)
    89.21(a)
      769735  XM_003641804.2  XP_003641852.1 
    lizard
    (Anolis carolinensis)
    Reptilia COX5A6
    cytochrome c oxidase subunit Va
    78(a)
    1 ↔ 1
    GL343492.1(557252-562409)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.241532 Xenopus laevis transcribed sequence with moderate similarity to protein spP20674 (H.sapiens) COXA_HUMAN CYTOCHROME C OXIDASE POLYPEPTIDE VA, MITOCHONDRIAL PRECURSOR less 85.24(n)    BX842797.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC059554.12   -- 79.31(n)    BC059554.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CoVa1 , 3 electron transport cytochrome c oxidase3
    Cytochrome c oxidase subunit Va1
    52(a)3
    56.02(n)1
    53.78(a)1
      3 86F93
    414321  NM_001275559.11  NP_001262488.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cco-21 cco-2 58.76(n)
    51.55(a)
      176707  NM_067280.5  NP_499681.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes COX6(YHR051W)4 Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels less   --   8(209705-210151) 856448  NP_011918.1 


    ENSEMBL Gene Tree for COX5A (if available)
    TreeFam Gene Tree for COX5A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for COX5A gene

    Find genes that share paralogs with COX5A           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for COX5A
    PGOHUM00000239877 PGOHUM00000247806 PGOHUM00000248170 PGOHUM00000262212 PGOHUM00000237489


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for COX5A (see all 423)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs11333231,2
    C,F,A,H--75212225(-) TACCTA/GTTCTT 1 -- ds500134Minor allele frequency- N:0.00MN EA NA NS 3336
    rs11333221,2
    C,F,A,H--75212357(-) CAAATT/CGTGTA 1 -- ds500127Minor allele frequency- C:0.25MN NS EA NA WA 2956
    rs570155571,2
    C,F--75212435(+) TTCTAG/CCCTTC 1 -- ds50014Minor allele frequency- C:0.20WA CSA 124
    rs1860573791,2
    --75212499(+) TCAGAC/TGGTTT 1 -- ds50010--------
    rs1136488631,2
    C--75212785(+) CCATCC/TGTAAG 1 -- spa10--------
    rs1394417051,2
    --75212880(+) ATCACA/TGTCTC 1 -- int10--------
    rs118588581,2
    H--75212980(+) TACTTC/GCTTCC 1 -- int1 trp30--------
    rs1920728971,2
    --75213041(+) GGGCCA/GGACAC 1 -- int10--------
    rs1450358501,2
    --75213137(+) AACACA/GGTGAA 1 -- int10--------
    rs1475757721,2
    --75213212(+) TACTCA/GGGAGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for COX5A (75212132 - 75230509 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for COX5A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2595466CNV Deletion19546169
    nsv904381CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COX5A
    DNA2.0 Custom Variant and Variant Library Synthesis for COX5A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603773    OMIM disorders: --

    12 diseases for COX5A:    
    About MalaCards
    leukocoria    acquired idiopathic sideroblastic anemia    multiple symmetric lipomatosis    swayback
    hair disease    cardioencephalomyopathy    ethylmalonic encephalopathy    alpers syndrome
    kearns-sayre syndrome    chronic progressive external ophthalmoplegia    lipomatosis    colon cancer

    3 diseases from the University of Copenhagen DISEASES database for COX5A:
    Protein C deficiency     Thrombophilia     Leukocoria

    Find genes that share disorders with COX5A           About GenesLikeMe

    Selected Novoseek inferred disease relationships for COX5A gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytochrome c oxidase deficiency 93.2 4 9545512 (1), 16773507 (1), 17508937 (1), 11312605 (1)
    leigh syndrome 89.6 51 9063742 (2), 12169463 (2), 2175026 (1), 1849240 (1) (see all 39)
    progressive external ophthalmoplegia 78.9 11 2175026 (1), 19251978 (1), 1312676 (1), 1330995 (1) (see all 8)
    mitochondrial diseases 78.4 22 9832034 (2), 19251978 (1), 19682572 (1), 9063742 (1) (see all 19)
    mitochondrial myopathies 77.5 9 1324295 (1), 7736281 (1), 11293802 (1), 8386896 (1) (see all 6)
    mitochondrial encephalomyopathies 74.8 7 7595643 (2), 18771761 (2), 8386896 (1), 17435251 (1) (see all 5)
    merrf 72.5 7 10477264 (2), 9037024 (1), 1606473 (1), 11850598 (1)
    acidosis lactic 65.7 7 19682572 (1), 19879173 (1), 11156535 (1), 14994243 (1) (see all 5)
    respiratory chain deficiency 65.2 1 9606056 (1)
    epilepsies myoclonic 64.7 4 10912924 (1), 1606473 (1), 9832034 (1)

    Genetic Association Database (GAD): COX5A
    Human Genome Epidemiology (HuGE) Navigator: COX5A (1 document)

    Export disorders for COX5A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for COX5A gene, integrated from 10 sources (see all 951):
    (articles sorted by number of sources associating them with COX5A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Subunit Va of human and bovine cytochrome c oxidase is highly conserved. (PubMed id 2853101)1, 2, 3 Rizzuto R.... Schon E.A. (Gene 1988)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates. (PubMed id 18197981)1, 2 Uddin M.... Grossman L.I. (BMC Evol. Biol. 2008)
    4. Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping. (PubMed id 10072584)1, 3 Hofmann S.... Meitinger T. (Cytogenet. Cell Genet. 1998)
    5. The major protein expression profile and two-dimensional protein database of human heart. (PubMed id 7498159)1, 2 Kovalyov L.I.... Musalyamov A.K. (Electrophoresis 1995)
    6. Human liver protein map: update 1993. (PubMed id 8313870)1, 2 Hughes G.J.... Hochstrasser D.F. (Electrophoresis 1993)
    7. Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2. (PubMed id 19834492)1, 9 Chen Z.X. and Pervaiz S. (Cell Death Differ. 2010)
    8. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    9. The role of cytochrome c oxidase subunit Va in non-small cell lung carcinoma cells: association with migration, invasion and prediction of distant metastasis. (PubMed id 22748147)1 Chen W.L....Wang L.S. (BMC Cancer 2012)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9377 HGNC: 2267 AceView: COX5A Ensembl:ENSG00000178741 euGenes: HUgn9377
    ECgene: COX5A Kegg: 9377 H-InvDB: COX5A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for COX5A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for COX5A gene:
    Search GeneIP for patents involving COX5A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for COX5A   OriGene RNAi products in human, mouse, rat for COX5A  
     OriGene qPCR primer pairs and template standards for COX5A   OriGene Protein Over-expression Lysate for COX5A  
     OriGene MassSpec something-or-other for COX5A   OriGene clones in human, mouse for COX5A  
     OriGene qSTAR qPCR primer pairs in human, mouse for COX5A   OriGene Purified Protein for COX5A  
     OriGene ORF clones in mouse, rat for COX5A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for COX5A   OriGene Custom Protein Services for COX5A  

     
     
     Block miRNA regulation of human, mouse, rat COX5A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing COX5A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COX5A Predesigned siRNA for gene silencing in human, mouse, rat COX5A
     QuantiFast Probe-based Assays in human, mouse, rat COX5A QuantiTect SYBR Green Assays in human, mouse, rat COX5A
     PCR Arrays including human, mouse, rat COX5A Search Chromatin IP Primers for COX5A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COX5A  GeneGlobe Interaction Network for COX5A
     Regulatory tfbs in COX5A promoter
     GenScript Custom Purified and Recombinant Proteins Services for COX5A GenScript cDNA clones with any tag delivered in your preferred vector for COX5A
     GenScript Custom Assay Services for COX5A GenScript Custom overexpressing Cell Line Services for COX5A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for COX5A
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     COX5A antibodies
     COX5A proteins
     COX5A lysates
     Antibodies for COX5A
     See all of Abcam's Antibodies, Kits and Proteins for COX5A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for COX5A
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for COX5A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX5A
     SwitchGear 3'UTR luciferase reporter plasmids for COX5A
     SwitchGear Promoter luciferase reporter plasmids for COX5A
     ThermoFisher Antibody for COX5A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX5A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COX5A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for COX5A
     LSBio Antibodies in human, mouse, rat for COX5A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for COX5A
      Search eBioscience for proteins for COX5A
      Search eBioscience for elisas for COX5A
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      COX5A gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4