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Aliases for COX5A Gene

Aliases for COX5A Gene

  • Cytochrome C Oxidase Subunit 5A 2 3
  • Cytochrome C Oxidase Subunit Va 2 3 5
  • Cytochrome C Oxidase Polypeptide Va 3 4
  • Cytochrome C Oxidase Polypeptide, Mitochondrial 3
  • Mitochondrial Cytochrome C Oxidase Subunit Va 3
  • COX-VA 3
  • COX 3
  • VA 3

External Ids for COX5A Gene

Previous GeneCards Identifiers for COX5A Gene

  • GC15M071071
  • GC15M068327
  • GC15M072788
  • GC15M072928
  • GC15M072999
  • GC15M075212
  • GC15M052009

Summaries for COX5A Gene

Entrez Gene Summary for COX5A Gene

  • Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Va of the human mitochondrial respiratory chain enzyme. A pseudogene COX5AP1 has been found in chromosome 14q22. [provided by RefSeq, Jul 2008]

GeneCards Summary for COX5A Gene

COX5A (Cytochrome C Oxidase Subunit 5A) is a Protein Coding gene. Diseases associated with COX5A include mitochondrial disorders and acquired idiopathic sideroblastic anemia. Among its related pathways are Alzheimer's disease and Cardiac muscle contraction. GO annotations related to this gene include electron carrier activity and cytochrome-c oxidase activity.

UniProtKB/Swiss-Prot for COX5A Gene

  • This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX5A Gene

Genomics for COX5A Gene

Regulatory Elements for COX5A Gene

Enhancers for COX5A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around COX5A on UCSC Golden Path with GeneCards custom track

Promoters for COX5A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COX5A on UCSC Golden Path with GeneCards custom track

Genomic Location for COX5A Gene

Chromosome:
15
Start:
74,919,791 bp from pter
End:
74,938,168 bp from pter
Size:
18,378 bases
Orientation:
Minus strand

Genomic View for COX5A Gene

Genes around COX5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX5A Gene

Proteins for COX5A Gene

  • Protein details for COX5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20674-COX5A_HUMAN
    Recommended name:
    Cytochrome c oxidase subunit 5A, mitochondrial
    Protein Accession:
    P20674
    Secondary Accessions:
    • P30045
    • Q8TB65

    Protein attributes for COX5A Gene

    Size:
    150 amino acids
    Molecular mass:
    16762 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX5A Gene

Proteomics data for COX5A Gene at MOPED

Post-translational modifications for COX5A Gene

  • Ubiquitination at Lys 62
  • Modification sites at PhosphoSitePlus

Other Protein References for COX5A Gene

Antibody Products

No data available for DME Specific Peptides for COX5A Gene

Domains & Families for COX5A Gene

Protein Domains for COX5A Gene

Suggested Antigen Peptide Sequences for COX5A Gene

Graphical View of Domain Structure for InterPro Entry

P20674

UniProtKB/Swiss-Prot:

COX5A_HUMAN :
  • Belongs to the cytochrome c oxidase subunit 5A family.
Family:
  • Belongs to the cytochrome c oxidase subunit 5A family.
genes like me logo Genes that share domains with COX5A: view

Function for COX5A Gene

Molecular function for COX5A Gene

GENATLAS Biochemistry:
cytochrome c oxidase,subunit Va,component of the complex IV,terminal enzyme complex for electron transfer,oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function:
This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
genes like me logo Genes that share phenotypes with COX5A: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COX5A Gene

Localization for COX5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX5A Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COX5A Gene COMPARTMENTS Subcellular localization image for COX5A gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytoskeleton 2
nucleus 2
plasma membrane 2
cytosol 1

Gene Ontology (GO) - Cellular Components for COX5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with COX5A: view

Pathways & Interactions for COX5A Gene

genes like me logo Genes that share pathways with COX5A: view

Gene Ontology (GO) - Biological Process for COX5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1902600 hydrogen ion transmembrane transport IEA,TAS --
genes like me logo Genes that share ontologies with COX5A: view

No data available for SIGNOR curated interactions for COX5A Gene

Drugs & Compounds for COX5A Gene

(76) Drugs for COX5A Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cholic acid Approved Pharma Full agonist, Agonist, Target 0
N-Formylmethionine Experimental Pharma Target 0
Alpha-D-Glucose 1,6-bisphosphate Experimental Pharma 0
heme Pharma Agonist 0

(63) Additional Compounds for COX5A Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
genes like me logo Genes that share compounds with COX5A: view

Transcripts for COX5A Gene

Unigene Clusters for COX5A Gene

Cytochrome c oxidase subunit Va:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COX5A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b
SP1: - -
SP2:
SP3: -
SP4: - - - - -

Relevant External Links for COX5A Gene

GeneLoc Exon Structure for
COX5A
ECgene alternative splicing isoforms for
COX5A

Expression for COX5A Gene

mRNA expression in normal human tissues for COX5A Gene

mRNA differential expression in normal tissues according to GTEx for COX5A Gene

This gene is overexpressed in Heart - Left Ventricle (x7.1) and Muscle - Skeletal (x5.0).

Protein differential expression in normal tissues from HIPED for COX5A Gene

This gene is overexpressed in Nasal epithelium (23.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COX5A Gene



SOURCE GeneReport for Unigene cluster for COX5A Gene Hs.401903

genes like me logo Genes that share expression patterns with COX5A: view

Protein tissue co-expression partners for COX5A Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for COX5A Gene

Orthologs for COX5A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for COX5A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COX5A 35
  • 90.22 (n)
  • 87.33 (a)
COX5A 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COX5A 35
  • 93.43 (n)
  • 90.91 (a)
-- 36
  • 87 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cox5a 35
  • 87.9 (n)
  • 87.67 (a)
Cox5a 16
Cox5a 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COX5A 35
  • 99.11 (n)
  • 98 (a)
COX5A 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cox5a 35
  • 88.13 (n)
  • 86.99 (a)
oppossum
(Monodelphis domestica)
Mammalia COX5A 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COX5A 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves COX5A 35
  • 80.82 (n)
  • 89.21 (a)
COX5A 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COX5A 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cox5a 35
  • 74.38 (n)
  • 76.87 (a)
Str.6885 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24153 35
zebrafish
(Danio rerio)
Actinopterygii cox5aa 35
  • 64.72 (n)
  • 73.72 (a)
cox5aa 36
  • 72 (a)
OneToMany
cox5aa 36
  • 72 (a)
OneToMany
cox5ab 36
  • 66 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6286 35
fruit fly
(Drosophila melanogaster)
Insecta CoVa 37
  • 52 (a)
CoVa 35
  • 56.02 (n)
  • 53.78 (a)
CoVa 36
  • 46 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011159 35
  • 60.63 (n)
  • 62.99 (a)
worm
(Caenorhabditis elegans)
Secernentea cco-2 35
  • 58.76 (n)
  • 51.55 (a)
cco-2 36
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COX6 36
  • 33 (a)
OneToOne
COX6 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4863 36
  • 49 (a)
OneToOne
Species with no ortholog for COX5A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COX5A Gene

ENSEMBL:
Gene Tree for COX5A (if available)
TreeFam:
Gene Tree for COX5A (if available)

Paralogs for COX5A Gene

genes like me logo Genes that share paralogs with COX5A: view

No data available for Paralogs for COX5A Gene

Variants for COX5A Gene

Sequence variations from dbSNP and Humsavar for COX5A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs6495131 -- 74,938,161(+) GGAGG(A/G)GCCAC upstream-variant-2KB
rs11858858 -- 74,920,639(+) TACTT(C/G)CTTCC intron-variant
rs12050585 -- 74,934,492(+) CGCCC(A/G)GCTAA intron-variant
rs12101557 -- 74,922,809(+) tacag(A/G)cacat intron-variant
rs12101835 -- 74,924,499(+) CTAGG(C/G)GACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COX5A Gene

Variant ID Type Subtype PubMed ID
nsv904381 CNV Loss 21882294
esv2595466 CNV Deletion 19546169

Variation tolerance for COX5A Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COX5A Gene

HapMap Linkage Disequilibrium report
COX5A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX5A Gene

Disorders for COX5A Gene

MalaCards: The human disease database

(22) MalaCards diseases for COX5A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mitochondrial disorders
  • mitochondrial encephalomyopathies
acquired idiopathic sideroblastic anemia
  • aisa
ethylmalonic encephalopathy
  • early myoclonic encephalopathy
kearns-sayre syndrome
  • mitochondrial myopathies
peripheral neuropathy
  • rare peripheral neuropathy
- elite association - COSMIC cancer census association via MalaCards
Search COX5A in MalaCards View complete list of genes associated with diseases

Relevant External Links for COX5A

Genetic Association Database (GAD)
COX5A
Human Genome Epidemiology (HuGE) Navigator
COX5A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COX5A
genes like me logo Genes that share disorders with COX5A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for COX5A Gene

Publications for COX5A Gene

  1. Subunit Va of human and bovine cytochrome c oxidase is highly conserved. (PMID: 2853101) Rizzuto R. … Schon E.A. (Gene 1988) 2 3 4 67
  2. Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2. (PMID: 19834492) Chen Z.X. … Pervaiz S. (Cell Death Differ. 2010) 3 23
  3. The Protein Data Bank. (PMID: 10592235) Berman H.M. … Bourne P.E. (Nucleic Acids Res. 2000) 25 26
  4. Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping. (PMID: 10072584) Hofmann S. … Meitinger T. (Cytogenet. Cell Genet. 1998) 2 3
  5. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3

Products for COX5A Gene

Sources for COX5A Gene

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