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Aliases for COX5A Gene

Aliases for COX5A Gene

  • Cytochrome C Oxidase Subunit Va 2 3
  • Cytochrome C Oxidase Polypeptide Va 3 4
  • Cytochrome C Oxidase Polypeptide, Mitochondrial 3
  • Cytochrome C Oxidase Subunit 5A, Mitochondrial 3
  • Mitochondrial Cytochrome C Oxidase Subunit Va 3
  • COX-VA 3
  • COX 3
  • VA 3

External Ids for COX5A Gene

Previous GeneCards Identifiers for COX5A Gene

  • GC15M071071
  • GC15M068327
  • GC15M072788
  • GC15M072928
  • GC15M072999
  • GC15M075212
  • GC15M052009

Summaries for COX5A Gene

Entrez Gene Summary for COX5A Gene

  • Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Va of the human mitochondrial respiratory chain enzyme. A pseudogene COX5AP1 has been found in chromosome 14q22. [provided by RefSeq, Jul 2008]

GeneCards Summary for COX5A Gene

COX5A (Cytochrome C Oxidase Subunit Va) is a Protein Coding gene. Diseases associated with COX5A include leukocoria and swayback. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include electron carrier activity and cytochrome-c oxidase activity.

UniProtKB/Swiss-Prot for COX5A Gene

  • This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX5A Gene

Genomics for COX5A Gene

Regulatory Elements for COX5A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COX5A Gene

74,919,791 bp from pter
74,938,168 bp from pter
18,378 bases
Minus strand

Genomic View for COX5A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COX5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX5A Gene

Proteins for COX5A Gene

  • Protein details for COX5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome c oxidase subunit 5A, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • P30045
    • Q8TB65

    Protein attributes for COX5A Gene

    150 amino acids
    Molecular mass:
    16762 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX5A Gene

Proteomics data for COX5A Gene at MOPED

Post-translational modifications for COX5A Gene

  • Ubiquitination at Lys62
  • Modification sites at PhosphoSitePlus

Other Protein References for COX5A Gene

No data available for DME Specific Peptides for COX5A Gene

Domains for COX5A Gene

Gene Families for COX5A Gene

  • comIV :Mitochondrial respiratory chain complex / Complex IV

Protein Domains for COX5A Gene

Suggested Antigen Peptide Sequences for COX5A Gene

Graphical View of Domain Structure for InterPro Entry



  • P20674
  • Belongs to the cytochrome c oxidase subunit 5A family.
genes like me logo Genes that share domains with COX5A: view

Function for COX5A Gene

Molecular function for COX5A Gene

GENATLAS Biochemistry: cytochrome c oxidase,subunit Va,component of the complex IV,terminal enzyme complex for electron transfer,oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function: This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Gene Ontology (GO) - Molecular Function for COX5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 cytochrome-c oxidase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0009055 electron carrier activity TAS 2853101
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with COX5A: view

Animal Model Products

CRISPR Products

miRNA for COX5A Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for COX5A Gene

Localization for COX5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX5A Gene

Mitochondrion inner membrane.

Subcellular locations from

Jensen Localization Image for COX5A Gene COMPARTMENTS Subcellular localization image for COX5A gene
Compartment Confidence
mitochondrion 5
extracellular 2
nucleus 2
plasma membrane 2
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for COX5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with COX5A: view

Pathways for COX5A Gene

genes like me logo Genes that share pathways with COX5A: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for COX5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0010467 gene expression TAS --
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with COX5A: view

Compounds for COX5A Gene

(3) HMDB Compounds for COX5A Gene

Compound Synonyms Cas Number PubMed IDs
  • trans-2-Hexadecenoyl-CoA
Alpha-D-Glucose 1,6-bisphosphate
  • Alpha-D-1,6-bis(dihydrogen phosphate) Glucopyranose
  • (protoporphyrinato)iron

(2) Drugbank Compounds for COX5A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cholic Acid
81-25-4 target

(134) Novoseek inferred chemical compound relationships for COX5A Gene

Compound -log(P) Hits PubMed IDs
arachidonic acid 86.6 130
prostaglandin 84.5 101
pge2 81 89
celecoxib 78.8 14
ns 398 75.8 8
genes like me logo Genes that share compounds with COX5A: view

Transcripts for COX5A Gene

Unigene Clusters for COX5A Gene

Cytochrome c oxidase subunit Va:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COX5A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COX5A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b
SP1: - -
SP3: -
SP4: - - - - -

Relevant External Links for COX5A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COX5A Gene

mRNA expression in normal human tissues for COX5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COX5A Gene

This gene is overexpressed in Heart - Left Ventricle (7.1) and Muscle - Skeletal (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COX5A Gene

SOURCE GeneReport for Unigene cluster for COX5A Gene Hs.401903

genes like me logo Genes that share expressions with COX5A: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for COX5A Gene

Orthologs for COX5A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for COX5A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COX5A 35
  • 99.11 (n)
  • 98 (a)
COX5A 36
  • 98 (a)
(Bos Taurus)
Mammalia COX5A 35
  • 90.22 (n)
  • 87.33 (a)
COX5A 36
  • 87 (a)
(Canis familiaris)
Mammalia -- 36
  • 87 (a)
-- 36
  • 88 (a)
COX5A 35
  • 93.43 (n)
  • 90.91 (a)
(Mus musculus)
Mammalia Cox5a 35
  • 87.9 (n)
  • 87.67 (a)
Cox5a 16
Cox5a 36
  • 87 (a)
(Monodelphis domestica)
Mammalia COX5A 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia COX5A 36
  • 77 (a)
(Rattus norvegicus)
Mammalia Cox5a 35
  • 88.13 (n)
  • 86.99 (a)
(Gallus gallus)
Aves COX5A 35
  • 80.82 (n)
  • 89.21 (a)
COX5A 36
  • 74 (a)
(Anolis carolinensis)
Reptilia COX5A 36
  • 78 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24153 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cox5a 35
  • 74.38 (n)
  • 76.87 (a)
Str.6885 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6286 35
(Danio rerio)
Actinopterygii cox5aa 35
  • 64.72 (n)
  • 73.72 (a)
cox5aa 36
  • 72 (a)
cox5aa 36
  • 72 (a)
cox5ab 36
  • 66 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011159 35
  • 60.63 (n)
  • 62.99 (a)
fruit fly
(Drosophila melanogaster)
Insecta CoVa 35
  • 56.02 (n)
  • 53.78 (a)
CoVa 36
  • 46 (a)
CoVa 37
  • 52 (a)
(Caenorhabditis elegans)
Secernentea cco-2 35
  • 58.76 (n)
  • 51.55 (a)
cco-2 36
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COX6 36
  • 33 (a)
COX6 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4863 36
  • 49 (a)
Species with no ortholog for COX5A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COX5A Gene

Gene Tree for COX5A (if available)
Gene Tree for COX5A (if available)

Paralogs for COX5A Gene

genes like me logo Genes that share paralogs with COX5A: view

No data available for Paralogs for COX5A Gene

Variants for COX5A Gene

Sequence variations from dbSNP and Humsavar for COX5A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1133322 -- 74,920,016(-) CAAAT(C/T)GTGTA downstream-variant-500B
rs1133323 -- 74,919,884(-) TACCT(A/G)TTCTT downstream-variant-500B
rs1800994 -- 74,926,808(-) TGCAG(ACGGTTA/CATC)AATGA cds-indel
rs1803316 -- 74,929,195(-) TCACA(A/G)GAGAC synonymous-codon, reference
rs1803317 -- 74,923,697(-) ACTGG(A/G)AATCT missense, reference

Structural Variations from Database of Genomic Variants (DGV) for COX5A Gene

Variant ID Type Subtype PubMed ID
nsv904381 CNV Loss 21882294
esv2595466 CNV Deletion 19546169

Relevant External Links for COX5A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX5A Gene

Disorders for COX5A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (13) Diseases for COX5A Gene including...

Search for COX5A Gene in MalaCards »

(3) University of Copenhagen DISEASES for COX5A Gene

(91) Novoseek inferred disease relationships for COX5A Gene

Disease -log(P) Hits PubMed IDs
cytochrome c oxidase deficiency 93.2 4
leigh syndrome 89.6 41
progressive external ophthalmoplegia 78.9 8
mitochondrial diseases 78.4 20
mitochondrial myopathies 77.5 6

Relevant External Links for COX5A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with COX5A: view

No data available for UniProtKB/Swiss-Prot for COX5A Gene

Publications for COX5A Gene

  1. Subunit Va of human and bovine cytochrome c oxidase is highly conserved. (PMID: 2853101) Rizzuto R. … Schon E.A. (Gene 1988) 2 3 4
  2. The major protein expression profile and two-dimensional protein database of human heart. (PMID: 7498159) Kovalyov L.I. … Musalyamov A.K. (Electrophoresis 1995) 3 4
  3. Human liver protein map: update 1993. (PMID: 8313870) Hughes G.J. … Hochstrasser D.F. (Electrophoresis 1993) 3 4
  4. Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping. (PMID: 10072584) Hofmann S. … Meitinger T. (Cytogenet. Cell Genet. 1998) 2 3
  5. Molecular evolution of the cytochrome c oxidase subunit 5A gene in primates. (PMID: 18197981) Uddin M. … Grossman L.I. (BMC Evol. Biol. 2008) 3 4

Products for COX5A Gene

Sources for COX5A Gene

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