Aliases for COX5A Gene
External Ids for COX5A Gene
Previous GeneCards Identifiers for COX5A Gene
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Va of the human mitochondrial respiratory chain enzyme. A pseudogene COX5AP1 has been found in chromosome 14q22. [provided by RefSeq, Jul 2008]
GeneCards Summary for COX5A Gene
COX5A (Cytochrome C Oxidase Subunit 5A) is a Protein Coding gene. Diseases associated with COX5A include Mitochondrial Disorders and Acquired Idiopathic Sideroblastic Anemia. Among its related pathways are Arachidonate Epoxygenase / Epoxide Hydrolase and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include electron carrier activity and cytochrome-c oxidase activity.
UniProtKB/Swiss-Prot for COX5A Gene
This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.