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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COX4I2 Gene

protein-coding   GIFtS: 52
GCID: GC20P030225

cytochrome c oxidase subunit IV isoform 2 (lung)

(Previous name: cytochrome c oxidase subunit IV isoform 2 )
(Previous symbol: COX4L2)
 Explore 14 diseases affiliated with
COX4I2 via our new
 Human Malady Compendium 
Biological research products
for COX4I2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Cytochrome C Oxidase Subunit IV Isoform 2 (Lung)1 2     Cytochrome C Oxidase Subunit IV Isoform 21 3
COX4L21 2 3     COX IV-22 3
COX4-21 2     COX42
COX4B1 2     Cytochrome C Oxidase Subunit 4 Isoform 2, Mitochondrial2
COXIV-21 2     Cytochrome C Oxidase Subunit IV-Like 22
DJ857M17.21     

External Ids:    HGNC: 162321   Entrez Gene: 847012   Ensembl: ENSG000001310557   OMIM: 6079765   UniProtKB: Q96KJ93   

Export aliases for COX4I2 gene to outside databases

Previous GC identifers: GC20P030013 GC20P030923 GC20P030970 GC20P029689 GC20P027014


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COX4I2:
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer
from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by
mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits
function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the
complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene,
however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which
plays a pivotal role in COX regulation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: COX42_HUMAN, Q96KJ9
Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in
mitochondrial electron transport

Gene Wiki entry for COX4I2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COX4I2 gene promoter:
         AP-2rep   GR   NF-1/L   Tal-1   RelA   NF-kappaB   E47   HEN1   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOX4I2 promoter sequence
   Search SABiosciences Chromatin IP Primers for COX4I2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COX4I2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.21   Ensembl cytogenetic band:  20q11.21   HGNC cytogenetic band: 20q11.21

COX4I2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COX4I2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P030225:  view genomic region     (about GC identifiers)

Start:
30,225,691 bp from pter      End:
30,232,809 bp from pter
Size:
7,119 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: COX42_HUMAN, Q96KJ9 (See protein sequence)
Recommended Name: Cytochrome c oxidase subunit 4 isoform 2, mitochondrial precursor  
Size: 171 amino acids; 20010 Da
Subcellular location: Mitochondrion inner membrane
Secondary accessions: Q6GTF4 Q9H0Z4

Explore the universe of human proteins at neXtProt for COX4I2: NX_Q96KJ9

COX4I2 Protein expression data from MOPED and PaxDb:    About this image 
COX4I2 Protein Expression

REFSEQ proteins: NP_115998.2  
ENSEMBL proteins: 
 ENSP00000365243  

Human Recombinant Protein Products for COX4I2: 
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Uscn Proteins for COX4I2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion ----
GO:0005751mitochondrial respiratory chain complex IV IC11311561
GO:0031966mitochondrial membrane ----

COX4I2 for ontologies           About GeneDecksing



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Uscn ELISAs and CLIAs for COX4I2


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

COX4I2 for domains           About GeneDecksing

2 InterPro domains/families:
 IPR013288 Cyt_c_oxidase_su4
 IPR004203 Cyt_c_oxidase_su4_fam

Graphical View of Domain Structure for InterPro Entry Q96KJ9

ProtoNet protein and cluster: Q96KJ9

1 Blocks protein family: IPB004203 Cytochrome c oxidase subunit IV

UniProtKB/Swiss-Prot: COX42_HUMAN, Q96KJ9
Similarity: Belongs to the cytochrome c oxidase IV family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: COX42_HUMAN, Q96KJ9
Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in
mitochondrial electron transport

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004129cytochrome-c oxidase activity IDA11311561
     
COX4I2 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for COX4I2:
 Increased cell number in S and  Synthetic lethal with Ras 

     5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cox4i2):
 behavior/neurological  growth/size  homeostasis/metabolism  immune system  respiratory system 

COX4I2 for phenotypes           About GeneDecksing

Animal Models:
     Mouse knock-out Cox4i2tm1Hutt for COX4I2
   inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for COX4I2 

miRNA
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Gene Editing
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Cell Line
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In Situ Assay
Products:
   

 
Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for COX4I2


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Oxidative phosphorylation0.63
Alzheimer's disease0.43
Parkinson's disease0.61
Huntington's disease0.40
2AMPK Enzyme Complex Pathway
AMPK Enzyme Complex Pathway1.00
3Cardiac muscle contraction
Cardiac muscle contraction1.00
4Metabolism
Metabolic pathways0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for COX4I2
    AMPK Enzyme Complex Pathway


5/6         Kegg Pathways  (Kegg details for COX4I2) (see all 6):
    Oxidative phosphorylation
Metabolic pathways
Cardiac muscle contraction
Alzheimer's disease
Parkinson's disease


COX4I2 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COX4I2

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/9 Interacting proteins for COX4I2 (Q96KJ93 ENSP000003652434) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
InteractantInteraction Details
GeneCardExternal ID(s)
CYCSP999993, ENSP000003077864I2D: score=2 STRING: ENSP00000307786
EIF3LQ9Y2623I2D: score=5 
COX6A1ENSP000002293794STRING: ENSP00000229379
COX6A2ENSP000002874904STRING: ENSP00000287490
MT-CO2ENSP000003548764STRING: ENSP00000354876
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006091generation of precursor metabolites and energy NAS11311561
GO:0045333cellular respiration NAS11911854
GO:0055114oxidation-reduction process NAS11311561

COX4I2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

COX4I2 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for COX4I2

2 HMDB Compounds for COX4I2    About this table
CompoundSynonyms CAS #PubMed Ids
OxygenOxygen (see all 5)7782-44-7--
WaterDihydrogen oxide (see all 2)7732-18-5--
1 Novoseek chemical compound relationship for COX4I2 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
oxygen 15.8 3 12882902 (1), 16981895 (1), 17937768 (1)

Search CenterWatch for drugs/clinical trials and news about COX4I2 / COX42 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for COX4I2 gene: 
NM_032609.2  

Unigene Cluster for COX4I2:

Cytochrome c oxidase subunit IV isoform 2 (lung)
Hs.277101  [show with all ESTs]
Unigene Representative Sequence: BX378238
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000376075(uc002wwj.1) ENST00000490030

miRNA
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Inhib. RNA
Products:
     
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OriGene shRNA RFP: COX4I2
OriGene siRNA: COX4I2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COX4I2
Sirion Biotech Custom design and validation of potent shRNA sequences against COX4I2 
Clone
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OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COX4I2 (see all 3)
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GenScript: all cDNA clones in your preferred vector: COX4I2 (NM_032609)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for COX4I2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX4I2 
Primer
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OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COX4I2
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COX4I2
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COX4I2

Additional cDNA sequence: 

AF257180.1 BC057779.1 HE647859.1 

2 DOTS entries:

DT.423933  DT.100711619 

19 AceView cDNA sequences:

BM701080 BM674171 NM_032609 F37152 CA431133 CR594972 BX280722 BC057779 
H79747 AI761226 BI035944 AF257180 BX378238 F28784 BM715837 AA602436 
CB997644 CB994277 AA975703 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

COX4I2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
COX4I2 Expression
About this image
See COX4I2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COX4I2

SOURCE GeneReport for Unigene cluster: Hs.277101

UniProtKB/Swiss-Prot: COX42_HUMAN, Q96KJ9
Tissue specificity: Highly expressed in lung

    SABiosciences Expression via Pathway-Focused PCR Array including COX4I2: 
          Mitochondrial Energy Metabolism in human mouse rat

Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COX4I2
In Situ
Assay Products:
 

 
Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for COX4I2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for COX4I2 gene from 6/19 species (see all 19)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cox4i21 , 5 cytochrome c oxidase subunit IV isoform 21, 5 79.92(n)1
74.27(a)1
  2 (75.41 cM)5
846821  NM_053091.21  NP_444321.11 
 1527541735 
lizard
(Anolis carolinensis)
Reptilia COX4I26
--
51(a)
1 ↔ 1
GL343768.1(157493-168168)
African clawed frog
(Xenopus laevis)
Amphibia Xl.238962 Xenopus laevis transcribed sequence with weak similarity more 75.48(n)    48060976 
zebrafish
(Danio rerio)
Actinopterygii BC059669.12   -- 72.97(n)   393776  BC059669.1 
fruit fly
(Drosophila melanogaster)
Insecta CoIV6
CG103966
--
33(a)
27(a)
many ↔ many
many ↔ many
2L(19958713-19960065)
2R(1241499-1242231)
worm
(Caenorhabditis elegans)
Secernentea W09C5.86
Protein W09C5.8
23(a)
1 → many
I(13658159-13659118)


ENSEMBL Gene Tree for COX4I2 (if available)
TreeFam Gene Tree for COX4I2 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for COX4I2 gene
COX4I12  
1 SIMAP similar gene for COX4I2 using alignment to 2 protein entries:     COX42_HUMAN (see all proteins):
COX4I1

COX4I2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/189 NCBI SNPs in COX4I2 are shown (see all 189    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1194559501,2
C,Fpathogenic36338675(+) CGGACG/AAGCGG 2 /K /E mis11Minor allele frequency- A:0.00NA 4550
rs60604251,2
C,F--27013079(+) CTGCTC/TGCCTC 1 -- us2k15Minor allele frequency- T:0.37WA NA 244
rs1122583021,2
C--27013173(+) TGTCTT/ATTTTT 1 -- us2k12Minor allele frequency- A:0.33WA CSA 3
rs61209501,2
C,A--27013796(+) caccaC/Tgccca 1 -- us2k12Minor allele frequency- T:0.25NA 4
rs60877111,2
C,A--27013824(+) tagtaA/Gagatg 1 -- us2k13Minor allele frequency- G:0.17NA 6
rs60888531,2
C,A--27014040(+) gtgctA/Gggatt 1 -- us2k13Minor allele frequency- G:0.17NA 6
rs60888541,2
C--27014083(+) CTTCTG/AGAGTA 1 -- us2k12Minor allele frequency- A:0.19NA 122
rs61196101,2
C,F,A,H--27014266(+) AGGAGG/TCGCTC 1 -- us2k1 tfbs316Minor allele frequency- T:0.28NS EA NA WA 780
rs60888551,2
C,A--27014518(+) CCCGCC/TACCCA 1 -- int14Minor allele frequency- T:0.37WA NA 242
rs61209531,2
H--27015134(+) TCCACC/TTGGAC 1 -- int14Minor allele frequency- T:0.00NS EA 416

HapMap Linkage Disequilibrium report for COX4I2 (30225691 - 30232809 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for COX4I2: --
Human Gene Mutation Database (HGMD): COX4I2

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COX4I2
DNA2.0 Custom Variant and Variant Library Synthesis for COX4I2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

COX4I2 for disorders           About GeneDecksing

OMIM gene information: 607976   
OMIM disorders: 612714  
UniProtKB/Swiss-Prot: COX42_HUMAN, Q96KJ9
  • Defects in COX4I2 are the cause of exocrine pancreatic insufficiency dyserythropoietic anemia and calvarial
  • hyperostosis (EPIDACH) [MIM:612714]. Patients present with pancreatic insufficiency, intestinal malabsorption, failure
    to thrive, and anemia soon after birth

    14 diseases for COX4I2:    About MalaCards
    exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis    calvarial hyperostosis    exocrine pancreatic insufficiency    dyserythropoietic anemia
    hyperostosis    steatorrhea    anemia    huntington's disease
    parkinson's disease    pancreatitis    hypoxia    prostatitis
    neuronitis    hiv type 1

    Human Genome Epidemiology (HuGE) Navigator: COX4I2 (2 documents)

    Export disorders for COX4I2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COX4I2 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with COX4I2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian subunit IV isoforms of cytochrome c oxidase. (PubMed id 11311561)1, 2, 3, 9 Huettemann M.... Grossman L.I. (2001)
    2. Exocrine pancreatic insufficiency, dyserythropoeitic anemia, and calvarial hyperostosis are caused by a mutation in the COX4I2 gene. (PubMed id 19268275)1, 2, 9 Shteyer E.... Elpeleg O. (2009)
    3. Transcription of mammalian cytochrome c oxidase subunit IV-2 is controlled by a novel conserved oxygen responsive element. (PubMed id 17937768)1, 3, 9 Huttemann M....Grossman L.I. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    8. Polymorphisms in mitochondrial genes and prostate can cer risk. (PubMed id 19064571)1 Wang L....Thibodeau S.N. (2008)
    9. HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. (PubMed id 17418790)1 Fukuda R....Semenza G.L. (2007)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84701 HGNC: 16232 AceView: COX4I2 Ensembl:ENSG00000131055 euGenes: HUgn84701
    ECgene: COX4I2 Kegg: 84701 H-InvDB: COX4I2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for COX4I2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for COX4I2 gene:
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