Aliases for COX4I1 Gene
External Ids for COX4I1 Gene
Previous Symbols for COX4I1 Gene
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. [provided by RefSeq, Jul 2008]
GeneCards Summary for COX4I1 Gene
COX4I1 (Cytochrome C Oxidase Subunit IV Isoform 1) is a Protein Coding gene. Diseases associated with COX4I1 include calvarial hyperostosis and exocrine pancreatic insufficiency. Among its related pathways are Cytoskeletal Signaling and Metabolism. GO annotations related to this gene include cytochrome-c oxidase activity. An important paralog of this gene is COX4I2.
UniProtKB/Swiss-Prot for COX4I1 Gene
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport