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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COX4I1 Gene

protein-coding   GIFtS: 61
GCID: GC16P085833

cytochrome c oxidase subunit IV isoform 1

(Previous name: cytochrome c oxidase subunit IV )
(Previous symbol: COX4)
 Explore 15 diseases affiliated with
COX4I1 via our new
 Human Malady Compendium 
Biological research products
for COX4I1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Cytochrome C Oxidase Subunit IV Isoform 11 2 3     COX IV-12 3
COX41 2 3 5     Cytochrome C Oxidase Subunit IV1
COX4-11 2     COXIV2
Cytochrome C Oxidase Polypeptide IV2 3     Cytochrome C Oxidase Subunit 4 Isoform 1, Mitochondrial2

External Ids:    HGNC: 22651   Entrez Gene: 13272   Ensembl: ENSG000001311437   OMIM: 1238645   UniProtKB: P130733   

Export aliases for COX4I1 gene to outside databases

Previous GC identifers: GC16P077058 GC16P086866 GC16P085573 GC16P085614 GC16P084390 GC16P071574


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COX4I1:
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme
complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton
electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and
nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping
activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and
assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial
respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation,
and shares a promoter with it. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: COX41_HUMAN, P13073
Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in
mitochondrial electron transport

Gene Wiki entry for COX4I1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COX4I1 gene promoter:
         MAZR   AML1a   HTF   NCX/Ncx   YY1   Max   PPAR-gamma1   PPAR-gamma2   c-Myc   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOX4I1 promoter sequence
   Search SABiosciences Chromatin IP Primers for COX4I1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COX4I1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.1   Ensembl cytogenetic band:  16q24.1   HGNC cytogenetic band: 16q24.1

COX4I1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COX4I1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P085833:  view genomic region     (about GC identifiers)

Start:
85,832,239 bp from pter      End:
85,840,650 bp from pter
Size:
8,412 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: COX41_HUMAN, P13073 (See protein sequence)
Recommended Name: Cytochrome c oxidase subunit 4 isoform 1, mitochondrial precursor  
Size: 169 amino acids; 19577 Da
Subcellular location: Mitochondrion inner membrane
Secondary accessions: B2R4J2 D3DUM7 Q6P666

Explore the universe of human proteins at neXtProt for COX4I1: NX_P13073

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P13073

  • COX4I1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001852.1  
    ENSEMBL proteins: 
     ENSP00000454869   ENSP00000455437   ENSP00000455030   ENSP00000253452   ENSP00000457513  
     ENSP00000457015   ENSP00000455301   ENSP00000456452   ENSP00000454714  
    Reactome Protein details: P13073
    Human Recombinant Protein Products: 
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    Novus Biologicals COX4I1 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for COX4I1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS--


    COX4I1 for ontologies           About GeneDecksing



    COX4I1 Antibody Products: 
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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    COX4I1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR013288 Cyt_c_oxidase_su4
     IPR004203 Cyt_c_oxidase_su4_fam

    Graphical View of Domain Structure for InterPro Entry P13073

    ProtoNet protein and cluster: P13073

    1 Blocks protein family: IPB004203 Cytochrome c oxidase subunit IV

    UniProtKB/Swiss-Prot: COX41_HUMAN, P13073
    Similarity: Belongs to the cytochrome c oxidase IV family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: COX41_HUMAN, P13073
    Function: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in
    mitochondrial electron transport

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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004129cytochrome-c oxidase activity IEA--


    COX4I1 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI phenotypic allele for Cox4i1 (no phenotypes)

    COX4I1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.1.00
    Oxidative phosphorylation0.63
    Respiratory electron transport0.81
    Parkinson's disease0.61
    Electron Transport Chain0.76
    Alzheimer's disease0.43
    The citric acid (TCA) cycle and respiratory electron transport0.72
    Huntington's disease0.40
    2Metabolism
    Metabolism1.00
    Metabolic pathways0.38
    3Glucose / Energy Metabolism
    Glucose / Energy Metabolism1.00
    4Cytoskeletal Signaling
    Cytoskeletal Signaling1.00
    5Apoptosis and Autophagy
    Apoptosis and Autophagy1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for COX4I1
        AMPK Enzyme Complex Pathway

    3 Cell Signaling Technology (CST) Pathways for COX4I1
        Apoptosis and Autophagy
    Cytoskeletal Signaling
    Glucose / Energy Metabolism

    1 BioSystems Pathway for COX4I1 
        Electron Transport Chain

    4        Reactome Pathways for COX4I1
        Respiratory electron transport
    Metabolism
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport


    5/6         Kegg Pathways  (Kegg details for COX4I1) (see all 6):
        Oxidative phosphorylation
    Metabolic pathways
    Cardiac muscle contraction
    Alzheimer's disease
    Parkinson's disease


    COX4I1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COX4I1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/259 Interacting proteins for COX4I1 (P130731, 2, 3 ENSP000002534524) via UniProtKB, MINT, STRING, and/or I2D (see all 259)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MT-CO2P004032, 3, ENSP000003548764MINT-8079030 I2D: score=1 STRING: ENSP00000354876
    HSPD1P108092, ENSP000003400194MINT-8079030 MINT-8152389 STRING: ENSP00000340019
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    TMBIM4Q9HC241, 3, ENSP000003509654EBI-1056574,EBI-1045545 I2D: score=2 STRING: ENSP00000350965
    NELFCDQ8IXH73, ENSP000003423004I2D: score=1 STRING: ENSP00000342300
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006091generation of precursor metabolites and energy TAS2157630
    GO:0007584response to nutrient IEA--
    GO:0022904respiratory electron transport chain TAS--
    GO:0044281small molecule metabolic process TAS--


    COX4I1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    COX4I1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for COX4I1

    2 HMDB Compounds for COX4I1    About this table
    CompoundSynonyms CAS #PubMed Ids
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for COX4I1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cholic Acid-- 81-25-4target--10592235
    N-Formylmethionine-- --target--10592235

    3 Novoseek chemical compound relationships for COX4I1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 36.2 3 20107110 (1), 19020050 (1), 1533218 (1)
    phospholipid 17.8 1 16800686 (1)
    lipid 14.8 3 8440696 (1), 2172017 (1)

    Search CenterWatch for drugs/clinical trials and news about COX4I1 / COX41 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for COX4I1 gene: 
    NM_001861.3  

    Unigene Cluster for COX4I1:

    Cytochrome c oxidase subunit IV isoform 1
    Hs.433419  [show with all ESTs]
    Unigene Representative Sequence: BF316148
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000565078 ENST00000570123 ENST00000568339(uc002fje.3 uc002fjf.3)
    ENST00000566115 ENST00000567241 ENST00000568794 ENST00000253452 ENST00000562336
    ENST00000563774 ENST00000567266 ENST00000561569 ENST00000566405 ENST00000564544
    ENST00000566617 ENST00000564648 ENST00000564903 ENST00000569997 ENST00000562929


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    Additional cDNA sequence: 

    AK311847.1 BC008704.1 BC021236.2 BC062437.1 BT019825.1 M21575.1 M34600.1 U90915.1 
    X54802.1 

    24/28 DOTS entries (see all 28):

    DT.100673712  DT.420414  DT.100039062  DT.92406997  DT.455163  DT.100862378  DT.120687900  DT.95363546 
    DT.95091958  DT.87014109  DT.95178636  DT.91767775  DT.120687925  DT.85101409  DT.95091949  DT.120687941 
    DT.95092027  DT.100862383  DT.101968064  DT.120687917  DT.91767776  DT.91863124  DT.91995104  DT.95091954 

    24/982 AceView cDNA sequences (see all 982):

    BQ271136 AA513023 BQ130653 AW327609 CA841904 BM663168 BM854697 BM700493 
    CR592979 CD613066 H06316 T61019 AA425535 BG034212 F11128 BU728209 
    BI335897 CR590992 CR591678 AI983416 CA774659 BQ026383 BM767046 BM773149 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for COX4I1 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b
    SP1:                                -     -                 -     -     -     -           -     -                           
    SP2:                                -                       -     -     -     -           -     -                           
    SP3:                                -     -                       -     -     -           -     -     -     -               
    SP4:                                -     -                 -     -     -     -           -                                 
    SP5:                                                        -     -     -     -           -     -     -                     


    ECgene alternative splicing isoforms for COX4I1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COX4I1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTATTTACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See COX4I1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COX4I1

    SOURCE GeneReport for Unigene cluster: Hs.433419

    UniProtKB/Swiss-Prot: COX41_HUMAN, P13073
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including COX4I1: 
              Mitochondrial Energy Metabolism in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for COX4I1 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves COX4I11 cytochrome c oxidase subunit IV isoform 1 69.23(n)
    69.82(a)
      415826  NM_001030577.1  NP_001025748.1 
    lizard
    (Anolis carolinensis)
    Reptilia COX4I16
    --
    71(a)
    1 ↔ 1
    GL343454.1(486719-490361)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.247622 Xenopus laevis transcribed sequence with weak similarity more 71.23(n)    48052114 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.281652 Danio rerio cytochrome c oxidase subunit IV isoform more 72.73(n)    AY391417.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG103961 CG10396 46.11(n)
    35.33(a)
      35491  NM_136324.3  NP_610168.1 
    worm
    (Caenorhabditis elegans)
    Secernentea W09C5.86
    Protein W09C5.8
    23(a)
    1 → many
    I(13658159-13659118)


    ENSEMBL Gene Tree for COX4I1 (if available)
    TreeFam Gene Tree for COX4I1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for COX4I1 gene
    COX4I22  
    2 SIMAP similar genes for COX4I1 using alignment to 7 protein entries:     COX41_HUMAN (see all proteins):
    C4orf26    COX4I2

    COX4I1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for COX4I1
    PGOHUM00000262205 PGOHUM00000247822


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/246 NCBI SNPs in COX4I1 are shown (see all 246    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1872351651,2
    --85831277(+) CTTGGA/GTGTCA 3 -- us2k1 int10--------
    rs1513255091,2
    --85831440(+) TTAAAC/TGAAAA 3 -- us2k1 int10--------
    rs1913253411,2
    --85831479(+) GGTCTA/GAAGCT 3 -- us2k1 int10--------
    rs1411563811,2
    --85831518(+) AACTCC/GATGGA 3 -- us2k1 int10--------
    rs96736381,2
    C,F,--85831570(+) GAAAAG/ACTACT 3 -- int1 us2k11Minor allele frequency- A:0.10WA 118
    rs1837942561,2
    --85831629(+) TCCCAC/TTGTAC 3 -- int1 us2k10--------
    rs1469272701,2
    --85831641(+) TCAATA/GAAGCT 3 -- int1 us2k10--------
    rs96736461,2
    C,F,--85831647(+) AAGCTG/CTCATT 3 -- us2k1 int1 tfbs31Minor allele frequency- C:0.10WA 118
    rs1380308161,2
    --85831651(+) TGTCAC/TTGCAA 3 -- us2k1 int10--------
    rs1434951911,2
    --85831688(+) GATCGG/TCTGCT 3 -- us2k1 int10--------

    HapMap Linkage Disequilibrium report for COX4I1 (85832239 - 85840650 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for COX4I1: --
    Human Gene Mutation Database (HGMD): COX4I1

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    COX4I1 for disorders           About GeneDecksing

    OMIM gene information: 123864    OMIM disorders: --

    15 diseases for COX4I1:    About MalaCards
    ceroid lipofuscinosis    calvarial hyperostosis    neuronal ceroid-lipofuscinosis    exocrine pancreatic insufficiency
    hyperostosis    batten disease    huntington's disease    parkinson's disease
    alzheimer's disease    prostate cancer    pancreatitis    anemia
    obesity    prostatitis    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: COX4I1 (1 document)

    Export disorders for COX4I1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COX4I1 gene, integrated from 9 sources (see all 82):
    (articles sorted by number of sources associating them with COX4I1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel use of a chimpanzee pseudogene for chromosomal mapping of human cytochrome c oxidase subunit IV. (PubMed id 2157630)1, 2, 3, 9 Lomax M.I.... Grossman L.I. (1990)
    2. Isolation of a cDNA clone encoding subunit IV of human cytochrome c oxidase. (PubMed id 2444497)1, 2, 3 Zeviani M.... Schon E.A. (1987)
    3. The 5-prime region of the COX4 gene contains a novel overlapping gene, NOC4. (PubMed id 10337626)1, 2, 9 Bachman N.J.... Lomax M.I. (1999)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Subunit IV of human cytochrome c oxidase, polymorphism and a putative isoform. (PubMed id 1311608)1, 2 van Kuilenburg A.B.P.... Muijsers A.O. (1992)
    6. Rapid evolution of the human gene for cytochrome c oxidase subunit IV. (PubMed id 1319058)1, 9 Lomax M.I....Grossman L.I. (1992)
    7. Cytochrome c oxidase and nitric oxide in action: molec ular mechanisms and pathophysiological implications. (PubMed id 21939634)1 Sarti P....Arese M. (2012)
    8. The mechanism for proton pumping in cytochrome c oxida se from an electrostatic and quantum chemical perspective. (PubMed id 21978537)1 Blomberg M.R. and Siegbahn P.E. (2012)
    9. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    10. HIV-1 Tat protein directly induces mitochondrial membr ane permeabilization and inactivates cytochrome c oxidase. (PubMed id 22419111)1 Lecoeur H....Jacotot E. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1327 HGNC: 2265 AceView: COX4I1 Ensembl:ENSG00000131143 euGenes: HUgn1327
    ECgene: COX4I1 Kegg: 1327 H-InvDB: COX4I1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COX4I1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for COX4I1 gene:
    Search GeneIP for patents involving COX4I1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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