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Aliases for COX19 Gene

Aliases for COX19 Gene

  • COX19, Cytochrome C Oxidase Assembly Factor 2 3
  • HCOX19 3 4
  • COX19 Cytochrome C Oxidase Assembly Homolog (S. Cerevisiae) 2
  • Cytochrome C Oxidase Assembly Homolog 19 (S. Cerevisiae) 2
  • COX19 Cytochrome C Oxidase Assembly Homolog 3
  • Cytochrome C Oxidase Assembly Protein COX19 3
  • COX19 Cytochrome C Oxidase Assembly Factor 5
  • Cytochrome C Oxidase Assembly Homolog 19 3

External Ids for COX19 Gene

Previous GeneCards Identifiers for COX19 Gene

  • GC07M000972
  • GC07M000939

Summaries for COX19 Gene

Entrez Gene Summary for COX19 Gene

  • COX19 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox19 protein may play a role in metal transport to the mitochondrial intermembrane space and assembly of complex IV of the mitochondrial respiratory chain (Sacconi et al., 2005 [PubMed 16212937]).[supplied by OMIM, Mar 2008]

GeneCards Summary for COX19 Gene

COX19 (COX19, Cytochrome C Oxidase Assembly Factor) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Mitochondrial protein import.

UniProtKB/Swiss-Prot for COX19 Gene

  • May be required for the assembly of mitochondrial cytochrome c oxidase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX19 Gene

Genomics for COX19 Gene

Regulatory Elements for COX19 Gene

Enhancers for COX19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around COX19 on UCSC Golden Path with GeneCards custom track

Promoters for COX19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COX19 on UCSC Golden Path with GeneCards custom track

Genomic Location for COX19 Gene

Chromosome:
7
Start:
898,778 bp from pter
End:
975,599 bp from pter
Size:
76,822 bases
Orientation:
Minus strand

Genomic View for COX19 Gene

Genes around COX19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX19 Gene

Proteins for COX19 Gene

  • Protein details for COX19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q49B96-COX19_HUMAN
    Recommended name:
    Cytochrome c oxidase assembly protein COX19
    Protein Accession:
    Q49B96
    Secondary Accessions:
    • A4FTX0

    Protein attributes for COX19 Gene

    Size:
    90 amino acids
    Molecular mass:
    10394 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX19 Gene

Post-translational modifications for COX19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COX19 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COX19 Gene

Domains & Families for COX19 Gene

Protein Domains for COX19 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for COX19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q49B96

UniProtKB/Swiss-Prot:

COX19_HUMAN :
  • Contains 1 CHCH domain.
  • Belongs to the COX19 family.
Domain:
  • Contains 1 CHCH domain.
Family:
  • Belongs to the COX19 family.
genes like me logo Genes that share domains with COX19: view

Function for COX19 Gene

Molecular function for COX19 Gene

UniProtKB/Swiss-Prot Function:
May be required for the assembly of mitochondrial cytochrome c oxidase.

Phenotypes for COX19 Gene

MGI mutant phenotypes for COX19:
inferred from 1 alleles
GenomeRNAi human phenotypes for COX19:
genes like me logo Genes that share phenotypes with COX19: view

Animal Models for COX19 Gene

MGI Knock Outs for COX19:

Animal Model Products

CRISPR Products

miRNA for COX19 Gene

miRTarBase miRNAs that target COX19

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for COX19 Gene

Localization for COX19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX19 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COX19 Gene COMPARTMENTS Subcellular localization image for COX19 gene
Compartment Confidence
mitochondrion 4
cytosol 3

Gene Ontology (GO) - Cellular Components for COX19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005758 mitochondrial intermembrane space IBA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with COX19: view

Pathways & Interactions for COX19 Gene

genes like me logo Genes that share pathways with COX19: view

Pathways by source for COX19 Gene

2 Reactome pathways for COX19 Gene

Interacting Proteins for COX19 Gene

Gene Ontology (GO) - Biological Process for COX19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009060 aerobic respiration IBA --
GO:0033617 mitochondrial respiratory chain complex IV assembly IBA --
genes like me logo Genes that share ontologies with COX19: view

No data available for SIGNOR curated interactions for COX19 Gene

Drugs & Compounds for COX19 Gene

No Compound Related Data Available

Transcripts for COX19 Gene

mRNA/cDNA for COX19 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for COX19 Gene

Cytochrome c oxidase assembly homolog 19 (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COX19 Gene

No ASD Table

Relevant External Links for COX19 Gene

GeneLoc Exon Structure for
COX19
ECgene alternative splicing isoforms for
COX19

Expression for COX19 Gene

mRNA expression in normal human tissues for COX19 Gene

Protein differential expression in normal tissues from HIPED for COX19 Gene

This gene is overexpressed in Heart (43.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for COX19 Gene



NURSA nuclear receptor signaling pathways regulating expression of COX19 Gene:

COX19

SOURCE GeneReport for Unigene cluster for COX19 Gene:

Hs.121593

mRNA Expression by UniProt/SwissProt for COX19 Gene:

Q49B96-COX19_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in skeletal muscle.
genes like me logo Genes that share expression patterns with COX19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for COX19 Gene

Orthologs for COX19 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for COX19 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COX19 34
  • 86.59 (n)
  • 88.51 (a)
COX19 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cox19 34
  • 81.27 (n)
  • 82.02 (a)
Cox19 16
Cox19 35
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COX19 34
  • 99.26 (n)
  • 98.89 (a)
COX19 35
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cox19 34
  • 80.9 (n)
  • 80.9 (a)
dog
(Canis familiaris)
Mammalia COX19 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COX19 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves COX19 34
  • 66.67 (n)
  • 65.17 (a)
COX19 35
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COX19 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cox19 34
  • 71.49 (n)
  • 78.31 (a)
Str.15707 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.34176 34
zebrafish
(Danio rerio)
Actinopterygii zgc:162175 34
  • 68.2 (n)
  • 74.71 (a)
COX19 35
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42496 35
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F45H11.5 35
  • 42 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COX19 35
  • 34 (a)
OneToOne
COX19 37
Species where no ortholog for COX19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COX19 Gene

ENSEMBL:
Gene Tree for COX19 (if available)
TreeFam:
Gene Tree for COX19 (if available)

Paralogs for COX19 Gene

Pseudogenes.org Pseudogenes for COX19 Gene

genes like me logo Genes that share paralogs with COX19: view

No data available for Paralogs for COX19 Gene

Variants for COX19 Gene

Sequence variations from dbSNP and Humsavar for COX19 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2178110 -- 965,486(+) TGCGG(C/T)CTGTG utr-variant-3-prime
rs2272379 -- 973,157(+) TGGAA(A/G)TCATA intron-variant
rs2293521 -- 969,330(+) CCCTC(C/T)GTCCT utr-variant-3-prime
rs7792825 -- 966,937(+) tgtgg(C/T)gcttg utr-variant-3-prime
rs7811207 -- 975,771(+) GGAAT(G/T)GGTGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for COX19 Gene

Variant ID Type Subtype PubMed ID
dgv11111n54 CNV loss 21841781
esv3571557 CNV loss 25503493
esv3571558 CNV loss 25503493
nsv1024118 CNV gain 25217958
nsv1028282 CNV gain 25217958
nsv1161477 CNV deletion 26073780
nsv464244 CNV loss 19166990
nsv464245 CNV gain 19166990
nsv509182 CNV insertion 20534489
nsv605699 CNV loss 21841781
nsv605700 CNV gain 21841781
nsv605705 CNV loss 21841781
nsv823958 CNV loss 20364138
nsv950784 CNV deletion 24416366

Variation tolerance for COX19 Gene

Residual Variation Intolerance Score: 53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COX19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COX19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX19 Gene

Disorders for COX19 Gene

Relevant External Links for COX19

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COX19

No disorders were found for COX19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX19 Gene

Publications for COX19 Gene

  1. hCOX18 and hCOX19: two human genes involved in cytochrome c oxidase assembly. (PMID: 16212937) Sacconi S. … Salviati L. (Biochem. Biophys. Res. Commun. 2005) 2 3 4 65
  2. COX19 mediates the transduction of a mitochondrial redox signal from SCO1 that regulates ATP7A-mediated cellular copper efflux. (PMID: 23345593) Leary S.C. … Shoubridge E.A. (Mol. Biol. Cell 2013) 2 3 65
  3. Studies of COX16, COX19, and PET191 in human cytochrome-c oxidase deficiency. (PMID: 15596615) Tay S.K.H. … Dimauro S. (Arch. Neurol. 2004) 2 3 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 65

Products for COX19 Gene

Sources for COX19 Gene

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