COX19 Gene
protein-coding GIFtS: 41
GCID: GC07M000972
|
|
cytochrome c oxidase assembly homolog 19 (S. cerevisiae)(Previous name: COX19 cytochrome c oxidase assembly homolog (S. cerevisiae)...)
| |
Aliases
for COX19 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cytochrome C Oxidase Assembly Homolog 19 (S. Cerevisiae)1 2 | | HCOX191 | | MGC1044751 | | COX19 Cytochrome C Oxidase Assembly Homolog (S. Cerevisiae)1 | | COX19 Cytochrome C Oxidase Assembly Homolog2 | | Cytochrome C Oxidase Assembly Protein COX192 |
Export aliases for COX19 gene to outside databases |
Summaries
for COX19 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for COX19:
COX19 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox19 protein may play a role in metaltransport to the mitochondrial intermembrane space and assembly of complex IV of the mitochondrial respiratory chain(Sacconi et al., 2005 (PubMed 16212937)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: COX19_HUMAN, Q49B96Function: May be required for the assembly of mitochondrial cytochrome c oxidase (By similarity)
|
Genomic Views
for COX19 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the COX19 gene promoter:
NF-1 NF-1/L NRSF form 1 Bach2 MIF-1 NRSF form 2 Roaz HEN1 SRY Zic1
Other transcription factors
Search SABiosciences Chromatin IP Primers for COX19
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COX19 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p22.3 Ensembl cytogenetic band: 7p22.3 HGNC cytogenetic band: 7p22.3COX19 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M000972: view genomic region
(about GC identifiers)
Start:
|
938,415 bp from pter |
End:
|
1,015,235 bp from pter |
Size:
|
76,821 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 1,059,119-1,069,865 |
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Proteins
for COX19 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: COX19_HUMAN, Q49B96 (See
protein sequence)Recommended Name: Cytochrome c oxidase assembly protein COX19 Size: 90 amino acids; 10394 Da
Subcellular location: Cytoplasm, cytosol
Secondary accessions: A4FTX0Explore the universe of human proteins at neXtProt for COX19: NX_Q49B96
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q49B96
COX19 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001026788.1
ENSEMBL proteins: ENSP00000413423 ENSP00000342015
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
COX19 for ontologies About GeneDecksing
COX19 Antibody Products:
Assay Products for COX19: |
Protein
Domains /
Families
for COX19 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
COX19 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q49B96ProtoNet protein and cluster: Q49B96 1 Blocks protein family: IPB010625 CHCH
UniProtKB/Swiss-Prot: COX19_HUMAN, Q49B96Similarity: Belongs to the COX19 familySimilarity: Contains 1 CHCH domain |
Function
for COX19 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: COX19_HUMAN, Q49B96Function: May be required for the assembly of mitochondrial cytochrome c oxidase (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COX19 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COX19
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: COX19 (NM_001031617) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COX19 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX19 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX19 |
|
Pathways & Interactions
for COX19 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COX19
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for COX19 (ENSP000003420154) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for COX19 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for COX19
Search CenterWatch for drugs/clinical trials and news about COX19
|
Transcripts
for COX19 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for COX19 gene: NM_001031617.2 Unigene Cluster for COX19: Cytochrome c oxidase assembly homolog 19 (S. cerevisiae) Hs.121593 [show with all ESTs]Unigene Representative Sequence: NM_0010316174 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000457254 ENST00000344111(uc003sjp.1) ENST00000466146 ENST00000466853
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COX19 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COX19
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: COX19 (NM_001031617) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COX19 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX19 |
Additional cDNA sequence: AK023185.1 AK130822.1 AY957566.1 BC042434.1 BC053372.1 BC058158.1 BC070383.1 BC103632.1 BC110420.1 5 DOTS entries: DT.100754628 DT.99983648 DT.101975144 DT.410251 DT.121061459
GeneLoc Exon Structure
|
Expression
for COX19 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| COX19 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTGAAACCC
About this image
See COX19 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COX19
SOURCE GeneReport for Unigene cluster: Hs.121593
UniProtKB/Swiss-Prot: COX19_HUMAN, Q49B96Tissue specificity: Ubiquitously expressed. Highly expressed in skeletal muscle
SABiosciences Custom PCR Arrays for COX19
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COX19
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COX19 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COX19 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COX19 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX19 |
Orthologs
for COX19 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for COX19 gene from 8/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Cox191 , 5 |
COX19 cytochrome c oxidase assembly homolog (S. cerevisiae)5
cytochrome c oxidase assembly protein 191 |
81.27(n)1
82.02(a)1 |
|
5 (78.40 cM)5
680331 NM_197980.11 NP_932097.11
1393361895 |
chicken
(Gallus gallus) |
Aves |
COX191 |
COX19 cytochrome c oxidase assembly homolog (S. cerevisiae) |
66.67(n)
65.17(a) |
|
416452 XM_414760.3 XP_414760.2 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.341762 |
Xenopus laevis transcribed sequences |
74.56(n) |
|
BX853648.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:1621751 |
zgc:162175 |
68.2(n)
74.71(a) |
|
100004173 NM_001110540.1 NP_001104010.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG424966 |
-- |
36(a) |
1 ↔ 1 |
2R(17579095-17580269) |
worm
(Caenorhabditis elegans) |
Secernentea |
F45H11.56 |
Protein F45H11.5 |
44(a) |
1 ↔ 1 |
I(10381073-10381966) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
COX19-26COX19-16 |
cytochrome c oxidase 19-1 |
37(a)30(a) |
many → 1many → 1 |
1(26235284-26237571) 1(24841123-24842411) |
rice
(Oryza sativa) |
Liliopsida |
-- |
CHCH domain containing protein, expressed |
36(a) |
1 ↔ 1 |
2(12382692-12384366) |
ENSEMBL Gene Tree for COX19 (if available)
TreeFam Gene Tree for COX19 (if available) |
Paralogs
for COX19 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for COX19 gene
COX19 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for COX19
PGOHUM00000235154
|
Genomic Variants
for COX19 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for COX19 (938415 - 1015235 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for COX19: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COX19 |
|
Disorders
/ Diseases
for COX19 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
COX19 for disorders About GeneDecksing
OMIM gene information: 610429
OMIM disorders: --
3  diseases for COX19: About MalaCardsmenkes disease twinning malaria
1 disease from the University of Copenhagen DISEASES database for COX19:Menkes disease Export disorders for COX19 gene to outside databases
|
Publications
for COX19 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for COX19 gene integrated from 9 sources:
(articles sorted by number of sources associating them with COX19) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- hCOX18 and hCOX19: two human genes involved in cytochrome c oxidase assembly. (PubMed id 16212937)1, 2, 3 Sacconi S....Salviati L. (2005)
- Studies of COX16, COX19, and PET191 in human cytochrome-c oxidase deficiency. (PubMed id 15596615)1, 3 Tay S.K.H.... Dimauro S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for COX19 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing COX19 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing COX19 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COX19 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for COX19 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for COX19 gene:
Search GeneIP for patents involving COX19
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for COX19 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for COX19 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COX19 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COX19 | | | OriGene Protein Over-expression Lysate for COX19 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for COX19 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COX19 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COX19 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for COX19 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for COX19 | | OriGene Custom Protein Services for COX19 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COX19 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COX19 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COX19 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COX19 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COX19 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COX19 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for COX19 |
| |  |  |  |  | | | | |
 |
 |
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 | | | COX19 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX19 |
|  |  |  | | | | Search ThermoFisher Antibodies for COX19 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX19 |
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