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Aliases for COX19 Gene

Aliases for COX19 Gene

  • COX19 Cytochrome C Oxidase Assembly Factor 2 3
  • HCOX19 3 4
  • COX19 Cytochrome C Oxidase Assembly Homolog (S. Cerevisiae) 2
  • Cytochrome C Oxidase Assembly Homolog 19 (S. Cerevisiae) 2
  • COX19 Cytochrome C Oxidase Assembly Homolog 3
  • Cytochrome C Oxidase Assembly Protein COX19 3
  • Cytochrome C Oxidase Assembly Homolog 19 3

External Ids for COX19 Gene

Summaries for COX19 Gene

Entrez Gene Summary for COX19 Gene

  • COX19 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox19 protein may play a role in metal transport to the mitochondrial intermembrane space and assembly of complex IV of the mitochondrial respiratory chain (Sacconi et al., 2005 [PubMed 16212937]).[supplied by OMIM, Mar 2008]

GeneCards Summary for COX19 Gene

COX19 (COX19 Cytochrome C Oxidase Assembly Factor) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COX19 Gene

  • May be required for the assembly of mitochondrial cytochrome c oxidase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX19 Gene

Genomics for COX19 Gene

Genomic Location for COX19 Gene

898,778 bp from pter
975,599 bp from pter
76,822 bases
Minus strand

Genomic View for COX19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COX19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX19 Gene

Regulatory Elements for COX19 Gene

Proteins for COX19 Gene

  • Protein details for COX19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome c oxidase assembly protein COX19
    Protein Accession:
    Secondary Accessions:
    • A4FTX0

    Protein attributes for COX19 Gene

    90 amino acids
    Molecular mass:
    10394 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COX19 Gene

Proteomics data for COX19 Gene at MOPED

Post-translational modifications for COX19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COX19 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COX19 Gene

Domains for COX19 Gene

Gene Families for COX19 Gene

  • MITOAF :Mitochondrial respiratory chain complex assembly factors

Protein Domains for COX19 Gene


Suggested Antigen Peptide Sequences for COX19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CHCH domain.:
    • Q49B96
  • Belongs to the COX19 family.:
    • Q49B96
genes like me logo Genes that share domains with COX19: view

Function for COX19 Gene

Molecular function for COX19 Gene

UniProtKB/Swiss-Prot Function: May be required for the assembly of mitochondrial cytochrome c oxidase.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for COX19 Gene

Localization for COX19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX19 Gene

Cytoplasm, cytosol.

Subcellular locations from

Jensen Localization Image for COX19 Gene COMPARTMENTS Subcellular localization image for COX19 gene
Compartment Confidence
cytosol 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for COX19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005758 mitochondrial intermembrane space IBA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with COX19: view

Pathways for COX19 Gene

SuperPathways for COX19 Gene

No Data Available

Interacting Proteins for COX19 Gene

Gene Ontology (GO) - Biological Process for COX19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009060 aerobic respiration IBA --
GO:0033617 mitochondrial respiratory chain complex IV assembly IBA --
genes like me logo Genes that share ontologies with COX19: view

No data available for Pathways by source for COX19 Gene

Transcripts for COX19 Gene

mRNA/cDNA for COX19 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for COX19 Gene

Cytochrome c oxidase assembly homolog 19 (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COX19 Gene

No ASD Table

Relevant External Links for COX19 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COX19 Gene

mRNA expression in normal human tissues for COX19 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COX19 Gene

SOURCE GeneReport for Unigene cluster for COX19 Gene Hs.121593

mRNA Expression by UniProt/SwissProt for COX19 Gene

Tissue specificity: Ubiquitously expressed. Highly expressed in skeletal muscle.
genes like me logo Genes that share expressions with COX19: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for COX19 Gene

Orthologs for COX19 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for COX19 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COX19 35
  • 99.26 (n)
  • 98.89 (a)
COX19 36
  • 55 (a)
(Bos Taurus)
Mammalia COX19 35
  • 86.59 (n)
  • 88.51 (a)
COX19 36
  • 87 (a)
(Canis familiaris)
Mammalia COX19 36
  • 84 (a)
(Mus musculus)
Mammalia Cox19 35
  • 81.27 (n)
  • 82.02 (a)
Cox19 16
Cox19 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia COX19 36
  • 77 (a)
(Rattus norvegicus)
Mammalia Cox19 35
  • 80.9 (n)
  • 80.9 (a)
(Gallus gallus)
Aves COX19 35
  • 66.67 (n)
  • 65.17 (a)
COX19 36
  • 62 (a)
(Anolis carolinensis)
Reptilia COX19 36
  • 56 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.34176 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cox19 35
  • 71.49 (n)
  • 78.31 (a)
Str.15707 35
(Danio rerio)
Actinopterygii COX19 36
  • 70 (a)
zgc:162175 35
  • 68.2 (n)
  • 74.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42496 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea F45H11.5 36
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COX19 36
  • 34 (a)
COX19 38
Species with no ortholog for COX19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COX19 Gene

Gene Tree for COX19 (if available)
Gene Tree for COX19 (if available)

Paralogs for COX19 Gene Pseudogenes for COX19 Gene

genes like me logo Genes that share paralogs with COX19: view

No data available for Paralogs for COX19 Gene

Variants for COX19 Gene

Sequence variations from dbSNP and Humsavar for COX19 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2397 -- 964,887(+) CAGCT(A/T)ATCAT utr-variant-3-prime
rs871172 -- 970,008(+) tccca(G/T)gctgg intron-variant
rs2178110 -- 965,486(+) TGCGG(C/T)CTGTG utr-variant-3-prime
rs2272379 -- 973,157(+) TGGAA(A/G)TCATA intron-variant
rs2293521 -- 969,330(+) CCCTC(C/T)GTCCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for COX19 Gene

Variant ID Type Subtype PubMed ID
dgv7074n71 CNV Loss 21882294
dgv7078n71 CNV Loss 21882294
nsv887128 CNV Loss 21882294
dgv7080n71 CNV Loss 21882294
nsv464244 CNV Loss 19166990
nsv509182 CNV Insertion 20534489
nsv464245 CNV Gain 19166990
nsv887140 CNV Loss 21882294
nsv887141 CNV Loss 21882294
nsv887142 CNV Gain 21882294
dgv7081n71 CNV Loss 21882294
dgv7082n71 CNV Loss 21882294
dgv7083n71 CNV Loss 21882294
nsv823958 CNV Loss 20364138

Relevant External Links for COX19 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX19 Gene

Disorders for COX19 Gene

(1) University of Copenhagen DISEASES for COX19 Gene

genes like me logo Genes that share disorders with COX19: view

No data available for UniProtKB/Swiss-Prot for COX19 Gene

Publications for COX19 Gene

  1. hCOX18 and hCOX19: two human genes involved in cytochrome c oxidase assembly. (PMID: 16212937) Sacconi S. … Salviati L. (Biochem. Biophys. Res. Commun. 2005) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Studies of COX16, COX19, and PET191 in human cytochrome-c oxidase deficiency. (PMID: 15596615) Tay S.K.H. … Dimauro S. (Arch. Neurol. 2004) 2 3
  4. COX19 mediates the transduction of a mitochondrial redox signal from SCO1 that regulates ATP7A-mediated cellular copper efflux. (PMID: 23345593) Leary S.C. … Shoubridge E.A. (Mol. Biol. Cell 2013) 2 3
  5. A genome-wide association study (GWAS) for bronchopulmonary dysplasia. (PMID: 23897914) Wang H. … O'Brodovich H.M. (Pediatrics 2013) 3

Products for COX19 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate COX19
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for COX19
    • Block miRNA regulation of COX19 using miScript Target Protectors

    Sources for COX19 Gene

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