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Aliases for COX16 Gene

Aliases for COX16 Gene

  • COX16, Cytochrome C Oxidase Assembly Homolog 2 3 5
  • C14orf112 3 4
  • Cytochrome C Oxidase Assembly Protein COX16 Homolog, Mitochondrial 3
  • COX16 Cytochrome C Oxidase Assembly Homolog (S. Cerevisiae) 2
  • Chromosome 14 Open Reading Frame 112 2
  • Cytochrome C Oxidase Assembly Factor 3
  • HSPC203 3

External Ids for COX16 Gene

Previous HGNC Symbols for COX16 Gene

  • C14orf112

Previous GeneCards Identifiers for COX16 Gene

  • GC14M069863
  • GC14M069682
  • GC14M070791
  • GC14M050959

Summaries for COX16 Gene

GeneCards Summary for COX16 Gene

COX16 (COX16, Cytochrome C Oxidase Assembly Homolog) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

Additional gene information for COX16 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX16 Gene

Genomics for COX16 Gene

Regulatory Elements for COX16 Gene

Enhancers for COX16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H070317 1 ENCODE 28 +41.5 41505 1.7 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF143 ATF7 REST COX16 RNU2-51P SLC8A3 ADAM20P1 ADAM21 PIR53064 LOC105370552
GH14H070358 1.2 ENCODE 20.7 +0.3 267 1.8 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZC3H11A SRSF5 MED6 COX16 SUSD6 PTTG4P RPL7AP6 SLC8A3 PIR53064
GH14H070254 1.1 Ensembl ENCODE 21.2 +104.6 104594 1.5 ELF3 TBP NFIB ARID4B SIN3A DMAP1 SLC30A9 ZNF350 EGR2 SP3 COX16 SRSF5 SLC8A3 RNU2-51P ADAM20 ENSG00000258422 LOC101928046 ADAM21P1
GH14H070291 0.5 ENCODE 29.6 +66.6 66592 2.9 FOXA2 ZBTB21 ZNF692 FEZF1 ZNF623 COX16 ADAM21P1 RNU2-51P SYNJ2BP LOC105370552 PIR53064
GH14H070378 0.6 ENCODE 20.2 -21.2 -21244 5.5 MAFF ZNF316 GATA3 MAFG FOXP2 EMSY MAFK ADAM21P1 COX16 SLC8A3 SYNJ2BP GC14M070313 GC14P070399
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around COX16 on UCSC Golden Path with GeneCards custom track

Promoters for COX16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000070310 331 2000 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZC3H11A

Genomic Locations for COX16 Gene

Genomic Locations for COX16 Gene
34,651 bases
Minus strand

Genomic View for COX16 Gene

Genes around COX16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX16 Gene

Proteins for COX16 Gene

  • Protein details for COX16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A6NDT5
    • A8K3X8

    Protein attributes for COX16 Gene

    106 amino acids
    Molecular mass:
    12293 Da
    Quaternary structure:
    No Data Available
    • No COX16 mutations have been detected in patients with cytochrome c oxidase (COX) deficiency.

neXtProt entry for COX16 Gene

Post-translational modifications for COX16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COX16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COX16 Gene

Domains & Families for COX16 Gene

Gene Families for COX16 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for COX16 Gene


Suggested Antigen Peptide Sequences for COX16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the COX16 family.
  • Belongs to the COX16 family.
genes like me logo Genes that share domains with COX16: view

Function for COX16 Gene

Gene Ontology (GO) - Molecular Function for COX16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with COX16: view
genes like me logo Genes that share phenotypes with COX16: view

miRNA for COX16 Gene

miRTarBase miRNAs that target COX16

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COX16 Gene

Localization for COX16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX16 Gene

Mitochondrion membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COX16 gene
Compartment Confidence
mitochondrion 5
extracellular 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for COX16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with COX16: view

Pathways & Interactions for COX16 Gene

genes like me logo Genes that share pathways with COX16: view

Gene Ontology (GO) - Biological Process for COX16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with COX16: view

No data available for SIGNOR curated interactions for COX16 Gene

Drugs & Compounds for COX16 Gene

No Compound Related Data Available

Transcripts for COX16 Gene

Unigene Clusters for COX16 Gene

COX16 cytochrome c oxidase assembly homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for COX16 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP3: - -

Relevant External Links for COX16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COX16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COX16 Gene

Protein differential expression in normal tissues from HIPED for COX16 Gene

This gene is overexpressed in Lung (53.8) and Frontal cortex (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for COX16 Gene

Protein tissue co-expression partners for COX16 Gene

NURSA nuclear receptor signaling pathways regulating expression of COX16 Gene:


SOURCE GeneReport for Unigene cluster for COX16 Gene:


Evidence on tissue expression from TISSUES for COX16 Gene

  • Skin(4.3)
  • Blood(4.1)
  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with COX16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for COX16 Gene

Orthologs for COX16 Gene

This gene was present in the common ancestor of animals.

Orthologs for COX16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COX16 33
  • 99.37 (n)
  • 99 (a)
(Canis familiaris)
Mammalia COX16 33 34
  • 86.79 (n)
(Bos Taurus)
Mammalia COX16 33 34
  • 85.85 (n)
(Mus musculus)
Mammalia Cox16 33 16 34
  • 85.53 (n)
(Rattus norvegicus)
Mammalia Cox16 33
  • 84.91 (n)
(Monodelphis domestica)
Mammalia COX16 34
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia COX16 34
  • 53 (a)
(Gallus gallus)
Aves COX16 33 34
  • 58.92 (n)
(Danio rerio)
Actinopterygii cox16 33 34
  • 64.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta l(3)neo43 34
  • 42 (a)
Species where no ortholog for COX16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COX16 Gene

Gene Tree for COX16 (if available)
Gene Tree for COX16 (if available)

Paralogs for COX16 Gene Pseudogenes for COX16 Gene

genes like me logo Genes that share paralogs with COX16: view

No data available for Paralogs for COX16 Gene

Variants for COX16 Gene

Sequence variations from dbSNP and Humsavar for COX16 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000187847 -- 70,331,935(+) AGGTA(A/G)GAGGT intron-variant
rs1000191632 -- 70,352,184(+) CTTTT(G/T)TATTT intron-variant
rs1000207560 -- 70,335,096(+) TAAAA(A/G)GAGAC intron-variant
rs1000219204 -- 70,351,746(+) TTCTC(C/T)TGTTT intron-variant
rs1000261281 -- 70,355,959(+) GGCAT(A/G)TGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COX16 Gene

Variant ID Type Subtype PubMed ID
nsv958777 CNV deletion 24416366
nsv952864 CNV deletion 24416366
nsv1142339 CNV deletion 24896259
nsv1116461 OTHER inversion 24896259
esv3634860 CNV loss 21293372
esv3184541 CNV deletion 24192839
esv2748836 CNV deletion 23290073
esv2748835 CNV deletion 23290073
dgv1099n106 CNV deletion 24896259

Variation tolerance for COX16 Gene

Residual Variation Intolerance Score: 55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COX16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX16 Gene

Disorders for COX16 Gene

Relevant External Links for COX16

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for COX16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX16 Gene

Publications for COX16 Gene

  1. Studies of COX16, COX19, and PET191 in human cytochrome-c oxidase deficiency. (PMID: 15596615) Tay SK … Dimauro S (Archives of neurology 2004) 2 3 4 60
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 60
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for COX16 Gene

Sources for COX16 Gene

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