COX16 Gene
protein-coding GIFtS: 43
GCID: GC14M070791
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COX16 cytochrome c oxidase assembly homolog (S. cerevisiae)(Previous name: chromosome 14 open reading frame 112 )
(Previous symbol: C14orf112)
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Aliases
for COX16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| COX16 Cytochrome C Oxidase Assembly Homolog (S. Cerevisiae)1 2 | | C14orf1121 2 3 | | HSPC2031 | | Chromosome 14 Open Reading Frame 1121 | | Cytochrome C Oxidase Assembly Factor2 | | Cytochrome C Oxidase Assembly Protein COX16 Homolog, Mitochondrial2 |
Export aliases for COX16 gene to outside databasesPrevious GC identifers: GC14M069863 GC14M069682 GC14M050959 |
Summaries
for COX16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for COX16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the COX16 gene promoter:
Nkx3-1 SRF ATF-2 SRF (504 AA) Nkx3-1 v1 HNF-3beta MEF-2A HFH-1 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for COX16
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COX16 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q24.2 Ensembl cytogenetic band: 14q24.2 HGNC cytogenetic band: 14q24.1COX16 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M070791: view genomic region
(about GC identifiers)
Start:
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70,791,798 bp from pter |
End:
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70,826,448 bp from pter |
Size:
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34,651 bases |
Orientation:
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minus strand |
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Proteins
for COX16 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: COX16_HUMAN, Q9P0S2 (See
protein sequence)Recommended Name: Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial precursor Size: 106 amino acids; 12293 Da
Subcellular location: Mitochondrion membrane; Single-pass membrane protein (Potential)
Miscellaneous: No COX16 mutations have been detected in patients with cytochrome c oxidase (COX) deficiency
Secondary accessions: A6NDT5 A8K3X8Explore the universe of human proteins at neXtProt for COX16: NX_Q9P0S2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P0S2
COX16 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001191019.1 NP_057552.1
ENSEMBL proteins: ENSP00000374562 ENSP00000450871
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
COX16 for ontologies About GeneDecksing
COX16 Antibody Products:
Assay Products for COX16: |
Protein
Domains /
Families
for COX16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
COX16 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9P0S2ProtoNet protein and cluster: Q9P0S2 UniProtKB/Swiss-Prot: COX16_HUMAN, Q9P0S2Similarity: Belongs to the COX16 family |
Function
for COX16 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COX16 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COX16
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): COX16 (NM_016468) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COX16 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX16 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX16 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
COX16 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for COX16:
|
Pathways & Interactions
for COX16 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COX16
2 Interacting proteins for COX16 (Q9P0S23) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
COX16 for ontologies About GeneDecksing
|
Drugs & Compounds
for COX16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for COX16
Search CenterWatch for drugs/clinical trials and news about COX16
|
Transcripts
for COX16 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for COX16 gene (2 alternative transcripts): NM_001204090.1 NM_016468.6 Unigene Cluster for COX16: COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) Hs.709581 [show with all ESTs]Unigene Representative Sequence: NM_0012025474 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000389912(uc001xmb.3 uc021rvl.1 uc021rvm.1 uc021rvn.1 uc021rvo.1)
ENST00000554366 ENST00000557612 ENST00000555601
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COX16 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COX16
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): COX16 (NM_016468) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COX16 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX16 |
Additional cDNA sequence: AF151037.1 AK290743.1 BC001702.2 CR457199.1 FJ460510.1 FJ460511.1 18 DOTS entries: DT.447101 DT.101986243 DT.92445266 DT.317641 DT.100672684 DT.120753732 DT.40303621 DT.120753728 DT.40238289 DT.120753702 DT.92445261 DT.95270949 DT.100736078 DT.120753729 DT.92005252 DT.92427003 DT.92445253 DT.95270947 24/511 AceView cDNA sequences (see all 511): BM799209 Z38720 BC007704 BM788927 BG256404 CR603483 W74556 AA888224 AI094741 BM561634 AA962803 AA430210 AA866190 AA931477 BX426019 BX404821 AA308541 CD677832 AA806448 AI086431 CR594391 AI051431 BQ023253 BU072260
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for COX16 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b |
|---|
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| SP1: | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | | | | | | |
ECgene alternative splicing isoforms for COX16
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Expression
for COX16 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| COX16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACAGGTTTT
About this image
See COX16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COX16
SOURCE GeneReport for Unigene cluster: Hs.709581
SABiosciences Custom PCR Arrays for COX16
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COX16
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COX16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COX16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COX16 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX16 |
Orthologs
for COX16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for COX16 gene from 4/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Cox161 , 5 |
COX16 cytochrome c oxidase assembly homolog (S. cerevisiae)5
cytochrome c oxidase assembly protein 161 |
85.53(n)1
84.91(a)1 |
|
12 (37.60 cM)5
662721 NM_025461.51 NP_079737.11
813590265 |
chicken
(Gallus gallus) |
Aves |
COX161 |
COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) |
58.92(n)
57.58(a) |
|
423257 NM_001197057.1 NP_001183986.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
cox161 |
COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) |
63.45(n)
66.27(a) |
|
550257 NM_001017594.1 NP_001017594.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
l(3)neo436 |
lethal (3) neo43 |
38(a) |
1 ↔ 1 |
3R(11103870-11104351) |
ENSEMBL Gene Tree for COX16 (if available)
TreeFam Gene Tree for COX16 (if available) |
Paralogs
for COX16 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for COX16 gene
COX16 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for COX16
PGOHUM00000234232
|
Genomic Variants
for COX16 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for COX16 (70791798 - 70826448 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for COX16: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COX16 |
|
Disorders
/ Diseases
for COX16 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
COX16 for disorders About GeneDecksing
2  diseases for COX16: About MalaCardsintrahepatic cholangiocarcinoma cholangiocarcinoma
Human Genome Epidemiology (HuGE) Navigator: COX16 (2 documents)
Export disorders for COX16 gene to outside databases
|
Publications
for COX16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for COX16 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with COX16) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Studies of COX16, COX19, and PET191 in human cytochrome-c oxidase deficiency. (PubMed id 15596615)1, 2, 3 Tay S.K.H.... Dimauro S. (2004)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
|
External Searches for COX16 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing COX16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing COX16 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COX16 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for COX16 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for COX16 gene:
Search GeneIP for patents involving COX16
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for COX16 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for COX16 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COX16 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COX16 | | | OriGene Protein Over-expression Lysate for COX16 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for COX16 | | OriGene 3'-UTR Clone for COX16 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COX16 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COX16 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for COX16 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for COX16 | | OriGene Custom Protein Services for COX16 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COX16 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COX16 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COX16 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COX16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COX16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COX16 |
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| |  |  |  |  | | | | |
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 | | | COX16 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX16 |
|  |  |  | | | | Search ThermoFisher Antibodies for COX16 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX16 |
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