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Aliases for COX16 Gene

Aliases for COX16 Gene

  • COX16, Cytochrome C Oxidase Assembly Homolog 2 3 5
  • C14orf112 3 4
  • Cytochrome C Oxidase Assembly Protein COX16 Homolog, Mitochondrial 3
  • COX16 Cytochrome C Oxidase Assembly Homolog (S. Cerevisiae) 2
  • Chromosome 14 Open Reading Frame 112 2
  • Cytochrome C Oxidase Assembly Factor 3
  • HSPC203 3

External Ids for COX16 Gene

Previous HGNC Symbols for COX16 Gene

  • C14orf112

Previous GeneCards Identifiers for COX16 Gene

  • GC14M069863
  • GC14M069682
  • GC14M070791
  • GC14M050959

Summaries for COX16 Gene

GeneCards Summary for COX16 Gene

COX16 (COX16, Cytochrome C Oxidase Assembly Homolog) is a Protein Coding gene. Among its related pathways are Metabolism and TP53 Regulates Metabolic Genes.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX16 Gene

Genomics for COX16 Gene

Regulatory Elements for COX16 Gene

Enhancers for COX16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F070291 0.4 ENCODE 29.6 +66.6 66592 2.9 ZNF146 ZNF692 ZNF140 FEZF1 NFE2 ZNF623 COX16 ADAM21P1 RNU2-51P ERH SYNJ2BP LOC105370552 PIR53064
GH14F070317 0.4 ENCODE 27.9 +41.5 41505 1.7 ATF1 MLX ARID4B DMAP1 YY1 SLC30A9 MIER2 REST PPARG KAT8 COX16 RNU2-51P SLC8A3 ADAM20P1 ADAM21 PIR53064 LOC105370552
GH14F070254 0.6 Ensembl ENCODE 21.2 +104.6 104594 1.5 ELF3 TBP ARID4B SIN3A DMAP1 ZNF48 RAD21 YY1 SLC30A9 EGR2 COX16 SLC8A3 RNU2-51P ADAM20 ENSG00000258422 LOC101928046 ADAM21P1
GH14F070358 0.2 ENCODE 20.7 +0.3 267 1.8 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NFYC MED6 COX16 RPL7AP6 ERH PTTG4P SUSD6 KRT18P7 SLC8A3 PIR53064
GH14F070378 0.4 ENCODE 20.2 -21.2 -21244 5.5 ZNF175 CEBPG ZNF316 GATA3 SCRT2 TRIM24 MAFK CEBPB MNT POLR2H ADAM21P1 COX16 SLC8A3 SYNJ2BP GC14M070313 GC14P070399
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around COX16 on UCSC Golden Path with GeneCards custom track

Promoters for COX16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000652223 331 2400 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NFYC

Genomic Location for COX16 Gene

Chromosome:
14
Start:
70,325,081 bp from pter
End:
70,359,731 bp from pter
Size:
34,651 bases
Orientation:
Minus strand

Genomic View for COX16 Gene

Genes around COX16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX16 Gene

Proteins for COX16 Gene

  • Protein details for COX16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0S2-COX16_HUMAN
    Recommended name:
    Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial
    Protein Accession:
    Q9P0S2
    Secondary Accessions:
    • A6NDT5
    • A8K3X8

    Protein attributes for COX16 Gene

    Size:
    106 amino acids
    Molecular mass:
    12293 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • No COX16 mutations have been detected in patients with cytochrome c oxidase (COX) deficiency.

neXtProt entry for COX16 Gene

Post-translational modifications for COX16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COX16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COX16 Gene

Domains & Families for COX16 Gene

Protein Domains for COX16 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for COX16 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P0S2

UniProtKB/Swiss-Prot:

COX16_HUMAN :
  • Belongs to the COX16 family.
Family:
  • Belongs to the COX16 family.
genes like me logo Genes that share domains with COX16: view

No data available for Gene Families for COX16 Gene

Function for COX16 Gene

Gene Ontology (GO) - Molecular Function for COX16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with COX16: view
genes like me logo Genes that share phenotypes with COX16: view

Animal Model Products

miRNA for COX16 Gene

miRTarBase miRNAs that target COX16

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COX16 Gene

Localization for COX16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX16 Gene

Mitochondrion membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COX16 Gene COMPARTMENTS Subcellular localization image for COX16 gene
Compartment Confidence
mitochondrion 5
extracellular 3

Gene Ontology (GO) - Cellular Components for COX16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with COX16: view

Pathways & Interactions for COX16 Gene

genes like me logo Genes that share pathways with COX16: view

Interacting Proteins for COX16 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000374562%0d%0a9606.ENSP00000354762%0d%0a
Selected Interacting proteins: ENSP00000374562 Q9P0S2-COX16_HUMAN for COX16 Gene via STRING IID

Gene Ontology (GO) - Biological Process for COX16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with COX16: view

No data available for SIGNOR curated interactions for COX16 Gene

Transcripts for COX16 Gene

Unigene Clusters for COX16 Gene

COX16 cytochrome c oxidase assembly homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COX16 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2:
SP3: - -

Relevant External Links for COX16 Gene

GeneLoc Exon Structure for
COX16
ECgene alternative splicing isoforms for
COX16

Expression for COX16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for COX16 Gene

Protein differential expression in normal tissues from HIPED for COX16 Gene

This gene is overexpressed in Lung (53.8) and Frontal cortex (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for COX16 Gene



Protein tissue co-expression partners for COX16 Gene

NURSA nuclear receptor signaling pathways regulating expression of COX16 Gene:

COX16

SOURCE GeneReport for Unigene cluster for COX16 Gene:

Hs.709581
genes like me logo Genes that share expression patterns with COX16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COX16 Gene

Orthologs for COX16 Gene

This gene was present in the common ancestor of animals.

Orthologs for COX16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COX16 34
  • 99.37 (n)
SYNJ2BP 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COX16 34 35
  • 86.79 (n)
cow
(Bos Taurus)
Mammalia COX16 34 35
  • 85.85 (n)
mouse
(Mus musculus)
Mammalia Cox16 34 16 35
  • 85.53 (n)
rat
(Rattus norvegicus)
Mammalia Cox16 34
  • 84.91 (n)
oppossum
(Monodelphis domestica)
Mammalia COX16 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COX16 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves COX16 34 35
  • 58.92 (n)
zebrafish
(Danio rerio)
Actinopterygii cox16 34 35
  • 64.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta l(3)neo43 35
  • 42 (a)
OneToOne
Species where no ortholog for COX16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COX16 Gene

ENSEMBL:
Gene Tree for COX16 (if available)
TreeFam:
Gene Tree for COX16 (if available)

Paralogs for COX16 Gene

Pseudogenes.org Pseudogenes for COX16 Gene

genes like me logo Genes that share paralogs with COX16: view

No data available for Paralogs for COX16 Gene

Variants for COX16 Gene

Sequence variations from dbSNP and Humsavar for COX16 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10133282 -- 70,361,182(+) TGAGG(A/C)AGGAG intron-variant, upstream-variant-2KB
rs10137455 -- 70,349,975(+) tcaag(A/C)atacc intron-variant
rs10138047 -- 70,358,250(+) ATTAG(C/T)TATGA intron-variant
rs10138156 -- 70,358,379(+) TTTTT(A/T)TTTTT intron-variant
rs10140161 -- 70,350,441(+) GTTGT(A/C)CATTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COX16 Gene

Variant ID Type Subtype PubMed ID
dgv1099n106 CNV deletion 24896259
esv2748835 CNV deletion 23290073
esv2748836 CNV deletion 23290073
esv3184541 CNV deletion 24192839
esv3634860 CNV loss 21293372
nsv1116461 OTHER inversion 24896259
nsv1142339 CNV deletion 24896259
nsv952864 CNV deletion 24416366
nsv958777 CNV deletion 24416366

Variation tolerance for COX16 Gene

Residual Variation Intolerance Score: 55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COX16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COX16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COX16 Gene

Disorders for COX16 Gene

Relevant External Links for COX16

Genetic Association Database (GAD)
COX16
Human Genome Epidemiology (HuGE) Navigator
COX16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COX16

No disorders were found for COX16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX16 Gene

Publications for COX16 Gene

  1. Studies of COX16, COX19, and PET191 in human cytochrome-c oxidase deficiency. (PMID: 15596615) Tay S.K.H. … Dimauro S. (Arch. Neurol. 2004) 2 3 4 64
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for COX16 Gene

Sources for COX16 Gene

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