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Aliases for COX16 Gene

Aliases for COX16 Gene

  • COX16 Cytochrome C Oxidase Assembly Homolog 2 3 5
  • C14orf112 3 4
  • COX16 Cytochrome C Oxidase Assembly Homolog (S. Cerevisiae) 2
  • Chromosome 14 Open Reading Frame 112 2
  • Cytochrome C Oxidase Assembly Factor 3
  • HSPC203 3

External Ids for COX16 Gene

Previous HGNC Symbols for COX16 Gene

  • C14orf112

Previous GeneCards Identifiers for COX16 Gene

  • GC14M069863
  • GC14M069682
  • GC14M070791
  • GC14M050959

Summaries for COX16 Gene

GeneCards Summary for COX16 Gene

COX16 (COX16 Cytochrome C Oxidase Assembly Homolog) is a Protein Coding gene. Among its related pathways are Gene Expression and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX16 Gene

Genomics for COX16 Gene

Regulatory Elements for COX16 Gene

Enhancers for COX16 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around COX16 on UCSC Golden Path with GeneCards custom track

Promoters for COX16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COX16 on UCSC Golden Path with GeneCards custom track

Genomic Location for COX16 Gene

70,325,081 bp from pter
70,359,731 bp from pter
34,651 bases
Minus strand

Genomic View for COX16 Gene

Genes around COX16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX16 Gene

Proteins for COX16 Gene

  • Protein details for COX16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A6NDT5
    • A8K3X8

    Protein attributes for COX16 Gene

    106 amino acids
    Molecular mass:
    12293 Da
    Quaternary structure:
    No Data Available
    • No COX16 mutations have been detected in patients with cytochrome c oxidase (COX) deficiency.

neXtProt entry for COX16 Gene

Proteomics data for COX16 Gene at MOPED

Post-translational modifications for COX16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COX16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COX16 Gene

Domains & Families for COX16 Gene

Protein Domains for COX16 Gene


Suggested Antigen Peptide Sequences for COX16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the COX16 family.
  • Belongs to the COX16 family.
genes like me logo Genes that share domains with COX16: view

No data available for Gene Families for COX16 Gene

Function for COX16 Gene

genes like me logo Genes that share phenotypes with COX16: view

Animal Model Products

CRISPR Products

miRNA for COX16 Gene

miRTarBase miRNAs that target COX16

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COX16 Gene

Localization for COX16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX16 Gene

Mitochondrion membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for COX16 Gene COMPARTMENTS Subcellular localization image for COX16 gene
Compartment Confidence
mitochondrion 5
extracellular 3

Gene Ontology (GO) - Cellular Components for COX16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with COX16: view

Pathways & Interactions for COX16 Gene

genes like me logo Genes that share pathways with COX16: view

Interacting Proteins for COX16 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000374562 Q9P0S2-COX16_HUMAN for COX16 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for COX16 Gene


No data available for SIGNOR curated interactions for COX16 Gene

Drugs & Compounds for COX16 Gene

No Compound Related Data Available

Transcripts for COX16 Gene

Unigene Clusters for COX16 Gene

COX16 cytochrome c oxidase assembly homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COX16 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP3: - -

Relevant External Links for COX16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COX16 Gene

mRNA expression in normal human tissues for COX16 Gene

Protein differential expression in normal tissues from HIPED for COX16 Gene

This gene is overexpressed in Lung (53.8) and Frontal cortex (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COX16 Gene

SOURCE GeneReport for Unigene cluster for COX16 Gene Hs.709581

genes like me logo Genes that share expression patterns with COX16: view

Protein tissue co-expression partners for COX16 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COX16 Gene

Orthologs for COX16 Gene

This gene was present in the common ancestor of animals.

Orthologs for COX16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia COX16 35
  • 85.85 (n)
  • 86.79 (a)
COX16 36
  • 88 (a)
(Canis familiaris)
Mammalia COX16 35
  • 86.79 (n)
  • 84.91 (a)
COX16 36
  • 85 (a)
(Mus musculus)
Mammalia Cox16 35
  • 85.53 (n)
  • 84.91 (a)
Cox16 16
Cox16 36
  • 85 (a)
(Pan troglodytes)
Mammalia COX16 35
  • 99.37 (n)
  • 99.06 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Cox16 35
  • 84.91 (n)
  • 84.91 (a)
(Monodelphis domestica)
Mammalia COX16 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia COX16 36
  • 53 (a)
(Gallus gallus)
Aves COX16 35
  • 58.92 (n)
  • 57.58 (a)
COX16 36
  • 50 (a)
(Danio rerio)
Actinopterygii cox16 35
  • 64.26 (n)
  • 67.47 (a)
cox16 36
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(3)neo43 36
  • 42 (a)
Species with no ortholog for COX16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COX16 Gene

Gene Tree for COX16 (if available)
Gene Tree for COX16 (if available)

Paralogs for COX16 Gene Pseudogenes for COX16 Gene

genes like me logo Genes that share paralogs with COX16: view

No data available for Paralogs for COX16 Gene

Variants for COX16 Gene

Structural Variations from Database of Genomic Variants (DGV) for COX16 Gene

Variant ID Type Subtype PubMed ID
nsv902075 CNV Gain 21882294
esv2748835 CNV Deletion 23290073
esv2748836 CNV Deletion 23290073

Variation tolerance for COX16 Gene

Residual Variation Intolerance Score: 55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 10.11% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for COX16 Gene

Disorders for COX16 Gene

Relevant External Links for COX16

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for COX16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX16 Gene

Publications for COX16 Gene

  1. Studies of COX16, COX19, and PET191 in human cytochrome-c oxidase deficiency. (PMID: 15596615) Tay S.K.H. … Dimauro S. (Arch. Neurol. 2004) 2 3 4 67
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 3
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3

Products for COX16 Gene

Sources for COX16 Gene