Aliases for COX11 Gene
- COX11 Cytochrome C Oxidase Copper Chaperone 2 3
- Cytochrome C Oxidase Subunit 11 2 3
- COX11 (Yeast) Homolog, Cytochrome C Oxidase Assembly Protein 2
- COX11 Homolog, Cytochrome C Oxidase Assembly Protein 3
- COX11 Cytochrome C Oxidase Assembly Homolog (Yeast) 2
- Cytochrome C Oxidase Assembly Homolog 11 (Yeast) 2
External Ids for COX11 Gene
Previous GeneCards Identifiers for COX11 Gene
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6. [provided by RefSeq, Jun 2009]
GeneCards Summary for COX11 Gene
COX11 (COX11 Cytochrome C Oxidase Copper Chaperone) is a Protein Coding gene. Among its related pathways are Metabolism and Gene Expression. GO annotations related to this gene include electron carrier activity and cytochrome-c oxidase activity.
UniProtKB/Swiss-Prot for COX11 Gene
Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.