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Aliases for COX11 Gene

Aliases for COX11 Gene

  • COX11 Cytochrome C Oxidase Copper Chaperone 2 3 5
  • Cytochrome C Oxidase Subunit 11 2 3
  • COX11 (Yeast) Homolog, Cytochrome C Oxidase Assembly Protein 2
  • COX11 Homolog, Cytochrome C Oxidase Assembly Protein 3
  • COX11 Cytochrome C Oxidase Assembly Homolog (Yeast) 2
  • Cytochrome C Oxidase Assembly Homolog 11 (Yeast) 2
  • Cytochrome C Oxidase Assembly Protein COX11 2
  • COX11P 3

External Ids for COX11 Gene

Previous GeneCards Identifiers for COX11 Gene

  • GC17M052759
  • GC17M055510
  • GC17M053339
  • GC17M053503
  • GC17M050384
  • GC17M053029
  • GC17M048388

Summaries for COX11 Gene

Entrez Gene Summary for COX11 Gene

  • Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6. [provided by RefSeq, Jun 2009]

GeneCards Summary for COX11 Gene

COX11 (COX11 Cytochrome C Oxidase Copper Chaperone) is a Protein Coding gene. Among its related pathways are Gene Expression and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include electron carrier activity and cytochrome-c oxidase activity.

UniProtKB/Swiss-Prot for COX11 Gene

  • Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX11 Gene

Genomics for COX11 Gene

Regulatory Elements for COX11 Gene

Enhancers for COX11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around COX11 on UCSC Golden Path with GeneCards custom track

Promoters for COX11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COX11 on UCSC Golden Path with GeneCards custom track

Genomic Location for COX11 Gene

Chromosome:
17
Start:
54,951,898 bp from pter
End:
54,968,785 bp from pter
Size:
16,888 bases
Orientation:
Minus strand

Genomic View for COX11 Gene

Genes around COX11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COX11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COX11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX11 Gene

Proteins for COX11 Gene

  • Protein details for COX11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6N1-COX11_HUMAN
    Recommended name:
    Cytochrome c oxidase assembly protein COX11, mitochondrial
    Protein Accession:
    Q9Y6N1
    Secondary Accessions:
    • D3DTY5
    • I3L220
    • Q6FHB7
    • Q9BRX0
    • Q9UME8

    Protein attributes for COX11 Gene

    Size:
    276 amino acids
    Molecular mass:
    31430 Da
    Quaternary structure:
    • Interacts with CNNM4/ACDP4.

    Alternative splice isoforms for COX11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COX11 Gene

Proteomics data for COX11 Gene at MOPED

Post-translational modifications for COX11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for COX11 Gene

Domains & Families for COX11 Gene

Protein Domains for COX11 Gene

Suggested Antigen Peptide Sequences for COX11 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6N1

UniProtKB/Swiss-Prot:

COX11_HUMAN :
  • Belongs to the COX11/CtaG family.
Family:
  • Belongs to the COX11/CtaG family.
genes like me logo Genes that share domains with COX11: view

Function for COX11 Gene

Molecular function for COX11 Gene

GENATLAS Biochemistry:
cytochrome c oxidase,subunit 11,inner mitochondrial membrane in yeast,maybe an heme biosynthetic enzyme
UniProtKB/Swiss-Prot Function:
Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
genes like me logo Genes that share phenotypes with COX11: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for COX11 Gene

Localization for COX11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX11 Gene

Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COX11 Gene COMPARTMENTS Subcellular localization image for COX11 gene
Compartment Confidence
mitochondrion 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for COX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
genes like me logo Genes that share ontologies with COX11: view

Pathways & Interactions for COX11 Gene

genes like me logo Genes that share pathways with COX11: view

Gene Ontology (GO) - Biological Process for COX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033132 negative regulation of glucokinase activity IEA --
GO:1902600 hydrogen ion transmembrane transport TAS 9878253
genes like me logo Genes that share ontologies with COX11: view

No data available for SIGNOR curated interactions for COX11 Gene

Drugs & Compounds for COX11 Gene

(1) Drugs for COX11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Pharma 161
genes like me logo Genes that share compounds with COX11: view

Transcripts for COX11 Gene

Unigene Clusters for COX11 Gene

Cytochrome c oxidase assembly homolog 11 (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COX11 Gene

No ASD Table

Relevant External Links for COX11 Gene

GeneLoc Exon Structure for
COX11
ECgene alternative splicing isoforms for
COX11

Expression for COX11 Gene

mRNA expression in normal human tissues for COX11 Gene

Protein differential expression in normal tissues from HIPED for COX11 Gene

This gene is overexpressed in Urine (48.1) and Peripheral blood mononuclear cells (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COX11 Gene



SOURCE GeneReport for Unigene cluster for COX11 Gene Hs.591171

mRNA Expression by UniProt/SwissProt for COX11 Gene

Q9Y6N1-COX11_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with COX11: view

Protein tissue co-expression partners for COX11 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for COX11 Gene

Orthologs for COX11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COX11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COX11 35
  • 87.7 (n)
  • 86.72 (a)
COX11 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COX11 35
  • 86.35 (n)
  • 84.42 (a)
COX11 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cox11 35
  • 84.67 (n)
  • 84.67 (a)
Cox11 16
Cox11 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC748332 35
  • 98.55 (n)
  • 97.83 (a)
COX11 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cox11 35
  • 84.48 (n)
  • 84 (a)
oppossum
(Monodelphis domestica)
Mammalia COX11 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COX11 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves COX11 35
  • 73.02 (n)
  • 78.57 (a)
COX11 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COX11 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491545 35
  • 72.79 (n)
  • 78.74 (a)
Str.5897 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.23905 35
zebrafish
(Danio rerio)
Actinopterygii cox11 35
  • 67.75 (n)
  • 73.02 (a)
Dr.14827 35
cox11 36
  • 63 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7260 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010443 35
  • 59.57 (n)
  • 63.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31648 35
  • 56.99 (n)
  • 59.45 (a)
CG31648 36
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea JC8.5 37
  • 58 (a)
CELE_JC8.5 35
  • 58.65 (n)
  • 55.61 (a)
cox-11 36
  • 45 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR106C 35
  • 55.43 (n)
  • 56.35 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D07007g 35
  • 56.69 (n)
  • 54.8 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COX11 35
  • 50.07 (n)
  • 47.68 (a)
COX11 36
  • 36 (a)
OneToOne
COX11 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G02410 35
  • 60.31 (n)
  • 55.49 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.1497 35
rice
(Oryza sativa)
Liliopsida Os.24044 35
Os03g0718600 35
  • 63.51 (n)
  • 61.05 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.6887 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7833 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cox1102 35
  • 60.89 (n)
  • 55.49 (a)
Species with no ortholog for COX11:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for COX11 Gene

ENSEMBL:
Gene Tree for COX11 (if available)
TreeFam:
Gene Tree for COX11 (if available)

Paralogs for COX11 Gene

Pseudogenes.org Pseudogenes for COX11 Gene

genes like me logo Genes that share paralogs with COX11: view

No data available for Paralogs for COX11 Gene

Variants for COX11 Gene

Sequence variations from dbSNP and Humsavar for COX11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_048831 -
rs2541240 -- 54,965,511(+) TATTT(A/G)TGTCT intron-variant
rs3213757 -- 54,964,496(+) TTTTT(A/G)ATAGT intron-variant
rs3217151 -- 54,964,537(+) TTTAA(-/CTTTTAA)GTTAC intron-variant
rs7223594 -- 54,963,678(+) GTATA(G/T)TTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COX11 Gene

Variant ID Type Subtype PubMed ID
nsv908620 CNV Loss 21882294
nsv457853 CNV Loss 19166990
nsv111920 CNV Loss 16902084
nsv522299 CNV Loss 19592680

Variation tolerance for COX11 Gene

Residual Variation Intolerance Score: 39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.74% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for COX11 Gene

Disorders for COX11 Gene

Relevant External Links for COX11

Genetic Association Database (GAD)
COX11
Human Genome Epidemiology (HuGE) Navigator
COX11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COX11

No disorders were found for COX11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COX11 Gene

Publications for COX11 Gene

  1. Physical interaction and functional coupling between ACDP4 and the intracellular ion chaperone COX11, an implication of the role of ACDP4 in essential metal ion transport and homeostasis. (PMID: 15840172) Guo D. … Wang C.-Y. (Mol. Pain 2005) 2 3 4 67
  2. Identification and characterization of human cDNAs specific to BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the formation and function of the mitochondrial respiratory chain. (PMID: 9878253) Petruzzella V. … Zeviani M. (Genomics 1998) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (PMID: 23535729) Michailidou K. … Easton D.F. (Nat. Genet. 2013) 3

Products for COX11 Gene

Sources for COX11 Gene

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