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Aliases for COX11 Gene

Aliases for COX11 Gene

  • COX11 Cytochrome C Oxidase Copper Chaperone 2 3
  • Cytochrome C Oxidase Subunit 11 2 3
  • COX11 (Yeast) Homolog, Cytochrome C Oxidase Assembly Protein 2
  • Cytochrome C Oxidase Assembly Protein COX11, Mitochondrial 3
  • COX11 Homolog, Cytochrome C Oxidase Assembly Protein 3
  • COX11 Cytochrome C Oxidase Assembly Homolog (Yeast) 2
  • Cytochrome C Oxidase Assembly Homolog 11 (Yeast) 2
  • Cytochrome C Oxidase Assembly Protein COX11 2
  • COX11 Cytochrome C Oxidase Assembly Homolog 3
  • Cytochrome C Oxidase Assembly Homolog 11 3
  • COX11P 3

External Ids for COX11 Gene

Summaries for COX11 Gene

Entrez Gene Summary for COX11 Gene

  • Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6. [provided by RefSeq, Jun 2009]

GeneCards Summary for COX11 Gene

COX11 (COX11 Cytochrome C Oxidase Copper Chaperone) is a Protein Coding gene. Among its related pathways are Metabolism and AMPK Enzyme Complex Pathway. GO annotations related to this gene include electron carrier activity and cytochrome-c oxidase activity.

UniProtKB/Swiss-Prot for COX11 Gene

  • Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COX11 Gene

Genomics for COX11 Gene

Genomic Location for COX11 Gene

Start:
54,951,898 bp from pter
End:
54,968,785 bp from pter
Size:
16,888 bases
Orientation:
Minus strand

Genomic View for COX11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COX11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COX11 Gene

Regulatory Elements for COX11 Gene

Proteins for COX11 Gene

  • Protein details for COX11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6N1-COX11_HUMAN
    Recommended name:
    Cytochrome c oxidase assembly protein COX11, mitochondrial
    Protein Accession:
    Q9Y6N1
    Secondary Accessions:
    • D3DTY5
    • I3L220
    • Q6FHB7
    • Q9BRX0
    • Q9UME8

    Protein attributes for COX11 Gene

    Size:
    276 amino acids
    Molecular mass:
    31430 Da
    Quaternary structure:
    • Interacts with CNNM4/ACDP4.

    Alternative splice isoforms for COX11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COX11 Gene

Proteomics data for COX11 Gene at MOPED

Post-translational modifications for COX11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COX11 Gene

No data available for DME Specific Peptides for COX11 Gene

Domains for COX11 Gene

Gene Families for COX11 Gene

HGNC:
  • MITOAF :Mitochondrial respiratory chain complex assembly factors

Protein Domains for COX11 Gene

UniProtKB/Swiss-Prot:

COX11_HUMAN
Family:
  • Belongs to the COX11/CtaG family.:
    • Q9Y6N1
genes like me logo Genes that share domains with COX11: view

Function for COX11 Gene

Molecular function for COX11 Gene

GENATLAS Biochemistry: cytochrome c oxidase,subunit 11,inner mitochondrial membrane in yeast,maybe an heme biosynthetic enzyme
UniProtKB/Swiss-Prot Function: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.

Gene Ontology (GO) - Molecular Function for COX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 cytochrome-c oxidase activity TAS 9878253
GO:0005507 copper ion binding IEA --
GO:0005515 protein binding --
GO:0009055 electron carrier activity TAS 9878253
genes like me logo Genes that share ontologies with COX11: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for COX11 Gene

Localization for COX11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COX11 Gene

Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COX11 Gene COMPARTMENTS Subcellular localization image for COX11 gene
Compartment Confidence
mitochondrion 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for COX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion TAS 9878253
GO:0005743 mitochondrial inner membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with COX11: view

Pathways for COX11 Gene

genes like me logo Genes that share pathways with COX11: view

Pathways by source for COX11 Gene

1 Qiagen pathway for COX11 Gene
1 BioSystems pathway for COX11 Gene
2 KEGG pathways for COX11 Gene

Gene Ontology (GO) - Biological Process for COX11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007585 respiratory gaseous exchange TAS 9878253
GO:0008535 respiratory chain complex IV assembly TAS 9878253
GO:0033132 negative regulation of glucokinase activity IEA --
GO:1902600 hydrogen ion transmembrane transport TAS 9878253
genes like me logo Genes that share ontologies with COX11: view

Compounds for COX11 Gene

(1) HMDB Compounds for COX11 Gene

Compound Synonyms Cas Number PubMed IDs
Copper
  • Cu
7440-50-8
genes like me logo Genes that share compounds with COX11: view

Transcripts for COX11 Gene

Unigene Clusters for COX11 Gene

Cytochrome c oxidase assembly homolog 11 (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COX11 Gene

No ASD Table

Relevant External Links for COX11 Gene

GeneLoc Exon Structure for
COX11
ECgene alternative splicing isoforms for
COX11

Expression for COX11 Gene

mRNA expression in normal human tissues for COX11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COX11 Gene

SOURCE GeneReport for Unigene cluster for COX11 Gene Hs.591171

mRNA Expression by UniProt/SwissProt for COX11 Gene

Q9Y6N1-COX11_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with COX11: view

Orthologs for COX11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COX11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COX11 37
  • 98 (a)
OneToOne
LOC748332 36
  • 98.55 (n)
  • 97.83 (a)
cow
(Bos Taurus)
Mammalia COX11 36
  • 87.7 (n)
  • 86.72 (a)
COX11 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COX11 36
  • 86.35 (n)
  • 84.42 (a)
COX11 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cox11 36
  • 84.67 (n)
  • 84.67 (a)
Cox11 16
Cox11 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COX11 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COX11 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cox11 36
  • 84.48 (n)
  • 84 (a)
chicken
(Gallus gallus)
Aves COX11 36
  • 73.02 (n)
  • 78.57 (a)
COX11 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COX11 37
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23905 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491545 36
  • 72.79 (n)
  • 78.74 (a)
Str.5897 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7260 36
zebrafish
(Danio rerio)
Actinopterygii cox11 36
  • 67.75 (n)
  • 73.02 (a)
cox11 37
  • 63 (a)
OneToOne
Dr.14827 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010443 36
  • 59.57 (n)
  • 63.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31648 36
  • 56.99 (n)
  • 59.45 (a)
CG31648 37
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_JC8.5 36
  • 58.65 (n)
  • 55.61 (a)
cox-11 37
  • 45 (a)
OneToOne
JC8.5 38
  • 58 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR106C 36
  • 55.43 (n)
  • 56.35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COX11 36
  • 50.07 (n)
  • 47.68 (a)
COX11 37
  • 36 (a)
OneToOne
COX11 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D07007g 36
  • 56.69 (n)
  • 54.8 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G02410 36
  • 60.31 (n)
  • 55.49 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.1497 36
rice
(Oryza sativa)
Liliopsida Os.24044 36
Os03g0718600 36
  • 63.51 (n)
  • 61.05 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.6887 36
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cox1102 36
  • 60.89 (n)
  • 55.49 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7833 36
Species with no ortholog for COX11:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for COX11 Gene

ENSEMBL:
Gene Tree for COX11 (if available)
TreeFam:
Gene Tree for COX11 (if available)

Paralogs for COX11 Gene

Pseudogenes.org Pseudogenes for COX11 Gene

genes like me logo Genes that share paralogs with COX11: view

No data available for Paralogs for COX11 Gene

Variants for COX11 Gene

Sequence variations from dbSNP and Humsavar for COX11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2541240 -- 54,965,511(+) TATTT(A/G)TGTCT intron-variant
rs3213757 -- 54,964,496(+) TTTTT(A/G)ATAGT intron-variant
rs3217151 -- 54,964,537(+) TTTAA(-/CTTTTAA)GTTAC intron-variant
rs7223594 -- 54,963,678(+) GTATA(G/T)TTGAG intron-variant
rs9915372 -- 54,966,536(+) cattc(C/T)tagcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COX11 Gene

Variant ID Type Subtype PubMed ID
nsv908620 CNV Loss 21882294
nsv457853 CNV Loss 19166990
nsv111920 CNV Loss 16902084
nsv522299 CNV Loss 19592680

Relevant External Links for COX11 Gene

HapMap Linkage Disequilibrium report
COX11

Disorders for COX11 Gene

(1) University of Copenhagen DISEASES for COX11 Gene

Relevant External Links for COX11

Genetic Association Database (GAD)
COX11
Human Genome Epidemiology (HuGE) Navigator
COX11
genes like me logo Genes that share disorders with COX11: view

No data available for UniProtKB/Swiss-Prot for COX11 Gene

Publications for COX11 Gene

  1. Physical interaction and functional coupling between ACDP4 and the intracellular ion chaperone COX11, an implication of the role of ACDP4 in essential metal ion transport and homeostasis. (PMID: 15840172) Guo D. … Wang C.-Y. (Mol. Pain 2005) 2 3 4
  2. Identification and characterization of human cDNAs specific to BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the formation and function of the mitochondrial respiratory chain. (PMID: 9878253) Petruzzella V. … Zeviani M. (Genomics 1998) 2 3 4
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. (PMID: 19330027) Ahmed S. … Easton D.F. (Nat. Genet. 2009) 3 49

Products for COX11 Gene

Sources for COX11 Gene

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