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COX11 Gene

protein-coding   GIFtS: 58
GCID: GC17M053029

Cytochrome C Oxidase Assembly Homolog 11 (Yeast)

(Previous names: COX11 (yeast) homolog, cytochrome c oxidase assembly protein,...)
  See COX11-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cytochrome C Oxidase Assembly Homolog 11 (Yeast)1 2     COX11P2
Cytochrome C Oxidase Subunit 111 2     COX11 Cytochrome C Oxidase Assembly Homolog2
COX11 (Yeast) Homolog, Cytochrome C Oxidase Assembly Protein1     COX11 Homolog, Cytochrome C Oxidase Assembly Protein2
COX11 Cytochrome C Oxidase Assembly Homolog (Yeast)1     Cytochrome C Oxidase Assembly Protein COX11, Mitochondrial2
Cytochrome C Oxidase Assembly Protein COX111     

External Ids:    HGNC: 22611   Entrez Gene: 13532   Ensembl: ENSG000001662607   OMIM: 6036485   UniProtKB: Q9Y6N13   

Export aliases for COX11 gene to outside databases

Previous GC identifers: GC17M052759 GC17M055510 GC17M053339 GC17M053503 GC17M050384 GC17M048388


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COX11 Gene:
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron
transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic
subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The
mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in
the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural
subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant
studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A
biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is
predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript
variants encoding different isoforms have been found for this gene. A related pseudogene has been found on
chromosome 6. (provided by RefSeq, Jun 2009)

GeneCards Summary for COX11 Gene:
COX11 (cytochrome c oxidase assembly homolog 11 (yeast)) is a protein-coding gene. Diseases associated with COX11 include breast cancer susceptibility, and leigh disease. GO annotations related to this gene include electron carrier activity and cytochrome-c oxidase activity.

UniProtKB/Swiss-Prot: COX11_HUMAN, Q9Y6N1
Function: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved
in the insertion of the copper B into subunit I (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the COX11 gene promoter:
         Max1   MEF-2   FOXD1   NF-AT   MEF-2A   NF-AT4   NF-AT2   NF-AT3   aMEF-2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOX11 promoter sequence
   Search Chromatin IP Primers for COX11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COX11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q22

COX11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COX11 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M053029:  view genomic region     (about GC identifiers)

Start:
53,029,259 bp from pter      End:
53,046,146 bp from pter
Size:
16,888 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for COX11

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: COX11_HUMAN, Q9Y6N1 (See protein sequence)
Recommended Name: Cytochrome c oxidase assembly protein COX11, mitochondrial precursor  
Size: 276 amino acids; 31430 Da
Subunit: Interacts with CNNM4/ACDP4
Secondary accessions: D3DTY5 I3L220 Q6FHB7 Q9BRX0 Q9UME8
Alternative splicing: 2 isoforms:  Q9Y6N1-1   Q9Y6N1-2   (No experimental confirmation available. Ref.4 (BI600359) sequence is in conflict in position: 223:V->G)

Explore the universe of human proteins at neXtProt for COX11: NX_Q9Y6N1

Explore proteomics data for COX11 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See COX11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001156333.1  NP_001156334.1  NP_004366.1  

    ENSEMBL proteins: 
     ENSP00000459901   ENSP00000459302   ENSP00000461191   ENSP00000299335   ENSP00000460043  

    COX11 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for COX11
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    Novus Biologicals COX11 Protein
    Novus Biologicals COX11 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for COX11

     
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    Search antibodies-online for peptides for COX11

    COX11 Antibody Products:

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    Search antibodies-online for antibodies for COX11 

    COX11 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MITOAF: Mitochondrial respiratory chain complex assembly factors

    2 InterPro protein domains:
     IPR007533 Cyt_c_oxidase_assmbl_CtaG
     IPR023471 CtaG/Cox11_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y6N1

    ProtoNet protein and cluster: Q9Y6N1

    1 Blocks protein domain: IPB007533 Cytochrome c oxidase assembly protein CtaG/Cox11

    UniProtKB/Swiss-Prot: COX11_HUMAN, Q9Y6N1
    Similarity: Belongs to the COX11/CtaG family


    Find genes that share domains with COX11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COX11_HUMAN, Q9Y6N1
    Function: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved
    in the insertion of the copper B into subunit I (By similarity)

         Genatlas biochemistry entry for COX11:
    cytochrome c oxidase,subunit 11,inner mitochondrial membrane in yeast,maybe an heme biosynthetic enzyme

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004129cytochrome-c oxidase activity TAS9878253
    GO:0005507copper ion binding IEA--
    GO:0005515protein binding ----
    GO:0009055electron carrier activity TAS9878253
         
    Find genes that share ontologies with COX11           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for COX11

    miRNA
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    Block miRNA regulation of human, mouse, rat COX11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate COX11 (see all 23):
    hsa-miR-579 hsa-miR-138-2* hsa-miR-507 hsa-miR-340 hsa-miR-374c hsa-miR-4325 hsa-miR-1909* hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidCOX11 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for COX11
    Predesigned siRNA for gene silencing in human, mouse, rat COX11

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): COX11 (NM_001162862)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COX11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX11

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COX11_HUMAN, Q9Y6N1: Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion TAS9878253
    GO:0005743mitochondrial inner membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with COX11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for COX11 About    
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Electron Transport Chain0.75
    Oxidative phosphorylation0.64
    2Metabolism
    Metabolic pathways0.38
    3AMPK Enzyme Complex Pathway
    AMPK Enzyme Complex Pathway


    Find genes that share SuperPaths with COX11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for COX11
        AMPK Enzyme Complex Pathway

    1 BioSystems Pathway for COX11
        Electron Transport Chain


    2 Kegg Pathways  (Kegg details for COX11):
        Oxidative phosphorylation
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for COX11
    Interactions:

        Search GeneGlobe Interaction Network for COX11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for COX11 (Q9Y6N13 ENSP000002993354) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COX15Q7KZN93, ENSP000000161714I2D: score=1 STRING: ENSP00000016171
    LACE1Q8WV933, ENSP000003579734I2D: score=1 STRING: ENSP00000357973
    COX10Q128873, ENSP000002616434I2D: score=2 STRING: ENSP00000261643
    SURF1Q155263, ENSP000003610424I2D: score=2 STRING: ENSP00000361042
    CATP040403, ENSP000002410524I2D: score=1 STRING: ENSP00000241052
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007585respiratory gaseous exchange TAS9878253
    GO:0008535respiratory chain complex IV assembly TAS9878253
    GO:0033132negative regulation of glucokinase activity IEA--
    GO:1902600hydrogen ion transmembrane transport TAS9878253

    Find genes that share ontologies with COX11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COX11

    1 HMDB Compound for COX11    About this table
    CompoundSynonyms CAS #PubMed Ids
    CopperCu (see all 2)7440-50-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for COX11 gene (3 alternative transcripts): 
    NM_001162861.1  NM_001162862.1  NM_004375.3  

    Unigene Cluster for COX11:

    Cytochrome c oxidase assembly homolog 11 (yeast)
    Hs.591171  [show with all ESTs]
    Unigene Representative Sequence: AK124809
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000576370(uc010wne.1 uc010wnf.1 uc002iue.2 uc010wng.1)
    ENST00000576084 ENST00000572088 ENST00000573912 ENST00000572558 ENST00000574821
    ENST00000574989 ENST00000299335 ENST00000571584(uc010wnh.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate COX11 (see all 23):
    hsa-miR-579 hsa-miR-138-2* hsa-miR-507 hsa-miR-340 hsa-miR-374c hsa-miR-4325 hsa-miR-1909* hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidCOX11 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat COX11
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COX11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX11
    Primer
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    OriGene qPCR primer pairs and template standards for COX11
    OriGene qSTAR qPCR primer pairs in human, mouse for COX11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COX11
      QuantiTect SYBR Green Assays in human, mouse, rat COX11
      QuantiFast Probe-based Assays in human, mouse, rat COX11

    Additional mRNA sequence: 

    AF044321.1 AK124809.1 AK127404.1 AK293851.1 AK295381.1 BC005895.1 CR541837.1 NR_027941.1 
    NR_027942.1 U79270.1 

    16 DOTS entries:

    DT.92452810  DT.118245  DT.120913778  DT.100826971  DT.100826973  DT.118242  DT.92452799  DT.75121909 
    DT.92452800  DT.97781384  DT.120913707  DT.92452805  DT.95235111  DT.87015632  DT.218198  DT.75119402 

    Selected AceView cDNA sequences (see all 232):

    BF725369 BE882783 AA258391 CA444970 CR600874 CR620872 CR617036 AI860867 
    AL557622 CB139130 BU154095 CB070316 CB141214 BM668632 BM699258 BM693358 
    CK904646 AA740457 AA370152 AA258340 CR625857 AI870665 BM743265 BQ434334 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COX11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGTTAAAA
    COX11 Expression
    About this image


    COX11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    COX11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COX11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591171

    UniProtKB/Swiss-Prot: COX11_HUMAN, Q9Y6N1
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COX11 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cox111 , 5 COX11 homolog, cytochrome c oxidase assembly protein more5
    cytochrome c oxidase assembly protein 111
    84.67(n)1
    84.67(a)1
      11 (55.45 cM)5
    698021  NM_199008.21  NP_950173.11 
     906381735 
    chicken
    (Gallus gallus)
    Aves COX111 COX11 cytochrome c oxidase assembly homolog (yeast) 73.02(n)
    78.57(a)
      770638  XM_001233972.3  XP_001233973.1 
    lizard
    (Anolis carolinensis)
    Reptilia COX116
    cytochrome c oxidase assembly homolog 11 (yeast)
    73(a)
    1 ↔ 1
    GL343242.1(1943436-1950034)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.239052 Xenopus laevis transcribed sequence with moderate similarity more 74.61(n)    BX849202.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.148272 Transcribed sequence with moderate similarity to protein more 76.39(n)    BM071741.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG316481 CG31648 56.99(n)
    59.45(a)
      33776  NM_164644.2  NP_723086.1 
    worm
    (Caenorhabditis elegans)
    Secernentea JC8.53
    CELE_JC8.51
    CELE_JC8.51 58(a)3
    58.65(n)1
    55.61(a)1
      IV(13245252-13247212)3
    1868141  NM_070146.31  NP_502547.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes COX11(YPL132W)4
    COX111
    Mitochondrial inner membrane protein required for delivery more4
    COX111
    50.07(n)1
    47.68(a)1
      16(301716-302618)4
    8559711, 4  NP_015193.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G024101 AT1G02410 60.31(n)
    55.49(a)
      839364  NM_100122.5  NP_171743.1 
    rice
    (Oryza sativa)
    Liliopsida Os.240442 Oryza sativa (japonica cultivar-group) cDNA clone0 more 72.2(n)    AK106450.1 


    ENSEMBL Gene Tree for COX11 (if available)
    TreeFam Gene Tree for COX11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for COX11 gene

    Find genes that share paralogs with COX11           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for COX11
    PGOHUM00000250822 PGOHUM00000243545


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COX11 (see all 94)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1855353001,2
    --53039840(+) AAAGCA/GGCTTA 5 -- ut31 int10--------
    rs1141897471,2
    C,F--53039978(+) GAAAAA/CATAAT 5 -- ut31 int11Minor allele frequency- C:0.07WA 118
    rs2005863561,2
    --53040119(+) GCAACA/TTGTGC 6 K M mis1 int10--------
    rs1451547171,2
    C,F--53040154(+) TAAGAA/CAGAGT 6 L syn1 int11Minor allele frequency- C:0.00NA 4478
    rs1409072871,2
    C--53040317(+) TTCTCA/GTATTA 5 -- int10--------
    rs612544271,2
    C,F--53040608(+) AGTTTC/TATACT 5 -- int12Minor allele frequency- T:0.07WA EA 238
    rs1157273811,2
    C,F--53040627(+) TCATGT/GATCTT 5 -- int11Minor allele frequency- G:0.07WA 118
    rs2016901641,2
    C--53040644(+) ATTCTG/ATAAAG 5 -- int11Minor allele frequency- A:0.00EU 1315
    rs1431752321,2
    C--53040648(+) TGTAAA/CGTTTA 5 -- int10--------
    rs1995795561,2
    --53040677(+) TTTTAC/TTGAAA 8 N S mis10--------

    HapMap Linkage Disequilibrium report for COX11 (53029259 - 53046146 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for COX11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv457853CNV Loss19166990
    nsv522299CNV Loss19592680
    nsv908620CNV Loss21882294
    nsv111920CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for COX11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603648    OMIM disorders: --

    2 diseases for COX11:    
    About MalaCards
    breast cancer susceptibility    leigh disease

    1 disease from the University of Copenhagen DISEASES database for COX11:
    Leigh disease

    Find genes that share disorders with COX11           About GenesLikeMe

    Genetic Association Database (GAD): COX11
    Human Genome Epidemiology (HuGE) Navigator: COX11 (5 documents)

    Export disorders for COX11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COX11 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with COX11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human cDNAs specific to BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the formation and function of the mitochondrial respiratory chain. (PubMed id 9878253)1, 2, 3 Petruzzella V....Zeviani M. (Genomics 1998)
    2. Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease. (PubMed id 20601676)1, 4 Fransen K....Weersma R.K. (Hum. Mol. Genet. 2010)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. (PubMed id 19330027)1, 4 Ahmed S....Easton D.F. (Nat. Genet. 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 2 Yu W.... Gibbs R.A. (Genome Res. 1997)
    7. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (PubMed id 23535729)1 Michailidou K....Easton D.F. (Nat. Genet. 2013)
    8. Association of STXBP4/COX11 rs6504950 (G&gt;A) polymorphism with breast cancer risk: evidence from 17,960 cases and 22,713 controls. (PubMed id 22863968)1 Tang L....Guan X.X. (Arch. Med. Res. 2012)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1353 HGNC: 2261 AceView: COX11 Ensembl:ENSG00000166260 euGenes: HUgn1353
    ECgene: COX11 Kegg: 1353 H-InvDB: COX11

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for COX11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for COX11 gene:
    Search GeneIP for patents involving COX11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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