COX10 Gene
protein-coding GIFtS: 59
GCID: GC17P013972
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|
cytochrome c oxidase assembly homolog 10 (yeast)(Previous names: COX10 (yeast) homolog, cytochrome c oxidase assembly protein...)
| |
Aliases
for COX10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cytochrome C Oxidase Assembly Homolog 10 (Yeast)1 2 | | Cytochrome C Oxidase Assembly Protein2 | | Heme O Synthase2 3 | | Cytochrome C Oxidase Subunit X2 | | COX10 (Yeast) Homolog, Cytochrome C Oxidase Assembly Protein (Heme A:Farnesyltransferase)1 | | Heme A: Farnesyltransferase2 | | COX10 Homolog, Cytochrome C Oxidase Assembly Protein, Heme A:Farnesyltransferase (Yeast)1 | | Protoheme IX Farnesyltransferase, Mitochondrial2 | | COX10 Homolog, Cytochrome C Oxidase Assembly Protein, Heme A:Farnesyltransferase2 | | EC 2.5.1.-3 |
Export aliases for COX10 gene to outside databasesPrevious GC identifers: GC17P014338 GC17P015087 GC17P013915 GC17P014173 GC17P013913 |
Summaries
for COX10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for COX10:
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electrontransfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalyticsubunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. Themitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in theregulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not astructural subunit but required for the expression of functional COX and functions in the maturation of the heme Aprosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrialinner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), isidentified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients withCMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressurepalsies) deletion. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: COX10_HUMAN, Q12887Function: Converts protoheme IX and farnesyl diphosphate to heme O (By similarity)
Gene Wiki entry for COX10
|
Genomic Views
for COX10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for COX10
Other transcription factors
Search SABiosciences Chromatin IP Primers for COX10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COX10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p12 Ensembl cytogenetic band: 17p12 HGNC cytogenetic band: 17p12COX10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P013972: view genomic region
(about GC identifiers)
Start:
|
13,972,719 bp from pter |
End:
|
14,111,996 bp from pter |
Size:
|
139,278 bases |
Orientation:
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plus strand |
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Proteins
for COX10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: COX10_HUMAN, Q12887 (See
protein sequence)Recommended Name: Protoheme IX farnesyltransferase, mitochondrial precursor Size: 443 amino acids; 48910 Da
Subcellular location: Mitochondrion membrane; Multi-pass membrane protein
Secondary accessions: B2R6U5 O15334 Q969F7Explore the universe of human proteins at neXtProt for COX10: NX_Q12887
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q12887
COX10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001294.2
ENSEMBL proteins: ENSP00000397750 ENSP00000261643 ENSP00000462512 ENSP00000462190 ENSP00000439494 ENSP00000443354
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
COX10 for ontologies About GeneDecksing
COX10 Antibody Products:
Assay Products for COX10: |
Protein
Domains /
Families
for COX10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
COX10 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q12887ProtoNet protein and cluster: Q12887 1 Blocks protein family: IPB000537 UbiA prenyltransferase
UniProtKB/Swiss-Prot: COX10_HUMAN, Q12887Similarity: Belongs to the UbiA prenyltransferase family |
Function
for COX10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: COX10_HUMAN, Q12887Function: Converts protoheme IX and farnesyl diphosphate to heme O (By similarity) Genatlas biochemistry entry for COX10:heme A
Enzyme Number (IUBMB): EC 2.5.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COX10 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COX10
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: COX10 (NM_001303) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COX10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX10 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX10 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
COX10 for ontologies About GeneDecksing
Animal Models:
8 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Cox10):
COX10 for phenotypes About GeneDecksing
|
Pathways & Interactions
for COX10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | AMPK Enzyme Complex Pathway | | | 2 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 3 | Metabolism | | | 4 | Glucuronidation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for COX10
3 
Kegg Pathways (Kegg details for COX10):
COX10 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COX10
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/53 Interacting proteins for COX10 (Q128873 ENSP000002616434) via UniProtKB, MINT, STRING, and/or I2D (see all 53)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
COX10 for ontologies About GeneDecksing
|
Drugs & Compounds
for COX10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for COX10
1 HMDB Compound for COX10 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Heme | (protoporphyrinato)iron (see all 19) | 14875-96-8 | -- |
Search CenterWatch for drugs/clinical trials and news about COX10
|
Transcripts
for COX10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for COX10 gene: NM_001303.3 Unigene Cluster for COX10: Cytochrome c oxidase assembly homolog 10 (yeast) Hs.462278 [show with all ESTs]Unigene Representative Sequence: NM_0013036 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000429152 ENST00000261643(uc002gof.4 uc010vvs.2 uc010vvt.2)
ENST00000581931 ENST00000580561 ENST00000536205 ENST00000537334
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COX10 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COX10
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: COX10 (NM_001303) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COX10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX10 |
Additional cDNA sequence: AK294213.1 AK295925.1 AK312718.1 BC000060.2 BC006394.2 BT006985.1 U09466.1 3 DOTS entries: DT.115568 DT.40116495 DT.91764152 24/157 AceView cDNA sequences (see all 157): AI278418 BM759715 BG251989 BQ050769 AA465683 AU132781 NM_001303 BE886560 AI269656 BM839014 AA573511 BM836347 AI355181 BM721108 BM793470 AU130428 AI915304 AA181301 AI362895 AI332955 BM833200 AI393884 BX506067 BE256423
GeneLoc Exon Structure
|
Expression
for COX10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| COX10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCAATGGCT
About this image
See COX10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COX10
SOURCE GeneReport for Unigene cluster: Hs.462278
SABiosciences Expression via Pathway-Focused PCR Array including COX10:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COX10
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COX10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COX10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COX10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX10 |
Orthologs
for COX10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for COX10 gene from 11/36 species (see all 36) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Cox101 , 5 |
COX10 homolog, cytochrome c oxidase assembly protein, more5
cytochrome c oxidase assembly protein 101 |
81.37(n)1
82.35(a)1 |
|
11 (39.47 cM)5
703831 NM_178379.31 NP_848466.11
639626275 |
chicken
(Gallus gallus) |
Aves |
COX101 |
COX10 homolog, cytochrome c oxidase assembly protein, more |
73.09(n)
72.84(a) |
|
417329 NM_001030700.1 NP_001025871.1 |
lizard
(Anolis carolinensis) |
Reptilia |
COX106 |
-- |
70(a) |
1 ↔ 1 |
2(106956463-107096337) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.37272 |
Xenopus laevis transcribed sequence with moderate similarity more |
78.48(n) |
|
BG579071.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb18a032 |
Transcribed sequence with moderate similarity to protein more |
75.87(n) |
|
CK027565.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG50371 , 3 |
protoheme IX farnesyltransferase3
CG50371 |
58(a)3
60.14(n)1
59.79(a)1 |
|
31D93
343941 NM_135538.21 NP_609382.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
Y46G5A.23
CELE_Y46G5A.21 |
Protein Y46G5A.21 |
52(a)3
53.79(n)1
47.98(a)1 |
|
II(12681627-12685676)3
1748991 NM_064307.41 NP_496708.21 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
COX10(YPL172C)4
COX101 |
Heme A:farnesyltransferase, catalyzes the first step more4
Cox10p1 |
45.29(n)1
36.62(a)1 |
|
16(225741-224353)4
8559311, 4 NP_015153.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
COX106 |
protoheme IX farnesyltransferase |
26(a) |
1 ↔ 1 |
2(18379564-18381942) |
rice
(Oryza sativa) |
Liliopsida |
-- |
prenyltransferase, putative, expressed |
28(a) |
1 ↔ 1 |
1(18960273-18967960) |
ENSEMBL Gene Tree for COX10 (if available)
TreeFam Gene Tree for COX10 (if available) |
Paralogs
for COX10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for COX10 gene
COX10 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for COX10
PGOHUM00000238353
|
Genomic Variants
for COX10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for COX10 (13972719 - 14111996 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for COX10
4 CNVs: 4022 3138 49816 32151
Human Gene Mutation Database (HGMD): COX10
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COX10 |
|
Disorders
/ Diseases
for COX10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
COX10 for disorders About GeneDecksing
OMIM gene information: 602125
OMIM disorders: --
UniProtKB/Swiss-Prot: COX10_HUMAN, Q12887
Defects in COX10 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known ascytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinicalmanifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs.Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness,excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patientsmanifest Leigh syndrome Defects in COX10 are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe neurological disordercharacterized by bilaterally symmetrical necrotic lesions in subcortical brain regions
14  diseases for COX10: About MalaCardshereditary neuropathy with liability to pressure palsy hereditary neuropathy with liability to pressure palsies encephalopathy, progressive mitochondrial, with proximal renal tubulopathy due to cytochrome c oxidase deficiency hereditary neuropathies
neuropathy leigh disease myopathy hypotonia
alzheimer's disease hypoxia tuberculosis hepatitis
malaria mycobacterium tuberculosis
1 disease from the University of Copenhagen DISEASES database for COX10:Leigh disease 4 Novoseek disease relationships for COX10 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cytochrome c oxidase deficiency |
93.3 |
2 |
10767350 (1), 16103131 (1) |
| charcot-marie-tooth disease |
75.3 |
1 |
9403059 (1) |
| mitochondrial diseases |
73.8 |
1 |
16103131 (1) |
| myopathy |
55.1 |
1 |
16103131 (1) |
Human Genome Epidemiology (HuGE) Navigator: COX10 (2 documents)
Export disorders for COX10 gene to outside databases
|
Publications
for COX10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for COX10 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with COX10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Genomic structure and expression of the human heme A:farnesyltransferase (COX10) gene. (PubMed id 9177788)1, 2, 3, 9 Murakami T.... Lupski J.R. (1997)
- A mutation in the human heme A:farnesyltransferase gene (COX10) causes cytochrome c oxidase deficiency. (PubMed id 10767350)1, 2, 9 Valnot I....Rotig A. (2000)
- Isolation of a human cDNA for heme A:farnesyltransferase by functional complementation of a yeast cox10 mutant. (PubMed id 8078902)1, 2, 9 Glerum M.D. and Tzagoloff A. (1994)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Mutations in COX10 result in a defect in mitochondrial heme A biosynthesis and account for multiple, early-onset clinical phenotypes associated with isolated COX deficiency. (PubMed id 12928484)1, 2 Antonicka H.... Shoubridge E.A. (2003)
- The human COX10 gene is disrupted during homologous recombination between the 24 kb proximal and distal CMT1A-REPs. (PubMed id 9285799)1, 9 Reiter L.T....Lupski J.R. (1997)
- The Charcot-Marie-Tooth binary repeat contains a gene transcribed from the opposite strand of a partially duplicated region of the COX10 gene. (PubMed id 9403059)1, 9 Kennerson M.L....Nicholson G.A. (1997)
- Cytochrome c oxidase biogenesis in a patient with a mutation in COX10 gene. (PubMed id 15455402)1, 9 Coenen M.J....Smeitink J.A. (2004)
- Cytochrome c oxidase subassemblies in fibroblast cultures from patients carrying mutations in COX10, SCO1, or SURF1. (PubMed id 14607829)1, 9 Williams S.L....Taanman J.W. (2004)
- Expression of the alternative oxidase complements cyt ochrome c oxidase deficiency in human cells. (PubMed id 20049701)1, 9 Dassa E.P....Rustin P. (2009)
|
External Searches for COX10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing COX10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing COX10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COX10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for COX10 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/COX10 |
|
| | |
About This Section
| Patent Information for COX10 gene:
Search GeneIP for patents involving COX10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for COX10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for COX10 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COX10 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COX10 | | | OriGene Protein Over-expression Lysate for COX10 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for COX10 | | OriGene 3'-UTR Clone for COX10 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COX10 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COX10 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for COX10 | | OriGene Custom Protein Services for COX10 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COX10 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COX10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COX10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COX10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COX10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COX10 |
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| | | | Search Tocris compounds for COX10 |
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 | | | COX10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COX10 |
|  |  |  | | | | ThermoFisher Antibody for COX10 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COX10 |
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