COTL1 Gene

Aliases
for COTL1 gene

Previous GC identifers: GC16M075449 GC16M085565 GC16M084338 GC16M084378 GC16M083156 GC16M070353

Summaries
for COTL1 gene

Genomic Views
for COTL1 gene

RefSeq DNA sequence:

NC_000016.9  NC_018927.1  NT_010498.15  

SwitchGear Promoter luciferase reporter plasmid: COTL1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COTL1

COTL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M084599:  view genomic region     (about GC identifiers)

Proteins
for COTL1 gene

6 PDB 3D structures from and Proteopedia for COTL1:

1T2L (3D)        1T3X (3D)        1T3Y (3D)        1TMW (3D)        1VFQ (3D)        1WNJ (3D)    

Explore the universe of human proteins at neXtProt for COTL1: NX_Q14019

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: COTL1 OriGene Protein Over-expression Lysate: COTL1 OriGene Custom Protein Services for COTL1
	GenScript Custom Purified and Recombinant Proteins Services for COTL1
	Novus Biologicals COTL1 Proteins Novus Biologicals COTL1 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for COTL1
	Uscn Proteins for COTL1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of COTL1
	R&D Systems Antibodies for COTL1 (Coactosin-like Protein 1/CotL1)
	Browse OriGene Antibodies OriGene Custom Antibody Services for COTL1
	GenScript Custom Superior Antibodies Services for COTL1
	Novus Biologicals COTL1 Antibodies
	Abcam antibodies for COTL1
	Uscn Antibodies for COTL1
	Search ThermoFisher Antibodies for COTL1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for COTL1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for COTL1

Protein Domains /
Families
for COTL1 gene

ProtoNet protein and cluster: Q14019

Function
for COTL1 gene

miRNA Products:		OriGene 3'-UTR Clone: COTL1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COTL1
		8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate COTL1 (see all 20):
		hsa-miR-30c hsa-miR-3910 hsa-miR-3607-3p hsa-miR-323b-3p hsa-miR-30d hsa-miR-30a hsa-miR-548g hsa-miR-124
		SwitchGear 3'UTR luciferase reporter plasmid: COTL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COTL1 (see all 7) OriGene shRNA RFP: COTL1 OriGene siRNA: COTL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COTL1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for COTL1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COTL1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COTL1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: COTL1 (NM_021149)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for COTL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COTL1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for COTL1
		Search LifeMap BioReagents cell lines for COTL1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COTL1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for COTL1 gene

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for COTL1 gene

Transcripts
for COTL1 gene

Expression
for COTL1 gene

COTL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCACATTTG

6 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	Gut TubeMidgutMidgut Endoderm Cells			Endoderm
	BrainCerebral Cortex			Brain
	BrainMedulla Oblongata			Brain
	EyeLens			Eye
	EyeRetina			Eye
	Gut TubeMidgut			Gut Tube
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COTL1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COTL1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COTL1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COTL1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COTL1

Orthologs
for COTL1 gene

Paralogs
for COTL1 gene

Paralogs for COTL1 gene

COTL1 for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for COTL1
PGOHUM00000237243 PGOHUM00000237289

Genomic Variants
for COTL1 gene

10/1412 NCBI SNPs in COTL1 are shown (see all 1412)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs58184951,2	C,F,	--	70354422(+)	ACATT-/AAAAAA	1	--	int1 trp3		3		NA CSA	6
rs1918601741,2		--	84598747(+)	ATGGCA/GAAACT	1	--	ds5001		0	--	--	--	--
rs1406383801,2		--	84598772(+)	AATACA/GATAAT	1	--	ds5001		0	--	--	--	--
rs1458085631,2		--	84598875(+)	GAGCTC/GAGATC	1	--	ds5001		0	--	--	--	--
rs1481582481,2		--	84598913(+)	AGAGTA/GAGACT	1	--	ds5001		0	--	--	--	--
rs2478661,2	C,F,H,	--	84598991(+)	AATGAG/ATCCCT	1	--	ds5001		16		NS EA NA WA CSA	793
rs2478651,2	C,F,A,	--	84599070(+)	TAAGCT/AATTGA	1	--	ds5001		12		NA WA CSA EA	375
rs1824893361,2		--	84599089(+)	GTGCCC/TCGCCT	1	--	ds5001		0	--	--	--	--
rs2478641,2	C,F,A,	--	84599090(+)	TGCCCG/CGCCTC	1	--	ds5001		12		NA WA CSA EA	375
rs2017834371,2	C	--	84599150(+)	TGTTAC/TTACAG	1	--	ds5001		0	--	--	--	--

HapMap Linkage Disequilibrium report for COTL1 (84599200 - 84651683 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for COTL1
     2 CNVs: 35416 0491

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COTL1

DNA2.0 Custom Variant and Variant Library Synthesis for COTL1

Disorders / Diseases
for COTL1 gene

10 diseases for COTL1

1 Novoseek disease relationship for COTL1 gene    About this table

Publications
for COTL1 gene

PubMed articles for COTL1 gene, integrated from 9 sources (see all 37): (articles sorted by number of sources associating them with COTL1)

Utopia: connect your pdf to the dynamic world of online information

1. Homologous recombination of a flanking repeat gene cluster is a mechanism for a common contiguous gene deletion syndrome. (PubMed id 9326934)^{1, 2, 3} Chen K.-S.... Lupski J.R. (1997)
2. Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production. (PubMed id 16924104)^{1, 3, 9} Rakonjac M....RAYdmark O. (2006)
3. Coactosin-like protein functions as a stabilizing cha perone for 5-lipoxygenase: role of tryptophan 102. (PubMed id 19807693)^{1, 2, 9} Esser J....RAYdmark O. (2010)
4. 5-lipoxygenase interacts with coactosin-like protein. (PubMed id 11297527)^{1, 2, 9} Provost P....Radmark O. (2001)
5. Coactosin-like protein, a human F-actin-binding protein: critical role of lysine-75. (PubMed id 11583571)^{1, 2, 9} Provost P....Radmark O. (2001)
6. Crystal structure of human coactosin-like protein at 1.9 A resolution. (PubMed id 15459340)^{1, 2, 9} Li X....Rao Z. (2004)
7. Binding model of human coactosin-like protein with filament actin revealed by mutagenesis. (PubMed id 17070122)^{1, 2, 9} Dai H....Shi Y. (2006)
8. Interaction of 5-lipoxygenase with cellular proteins. (PubMed id 10051563)^{1, 3, 9} Provost P.... Radmark O. (1999)
9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

External Searches for COTL1 gene

Genome Databases showing COTL1 gene

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Specialized Databases showing COTL1 gene

Products
for COTL1 gene