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Aliases for COTL1 Gene

Aliases for COTL1 Gene

  • Coactosin Like F-Actin Binding Protein 1 2 3
  • Coactosin-Like F-Actin Binding Protein 1 2 3 5
  • CLP 3 4
  • Coactosin-Like 1 (Dictyostelium) 2
  • Coactosin-Like 1 3

External Ids for COTL1 Gene

Previous GeneCards Identifiers for COTL1 Gene

  • GC16M075449
  • GC16M085565
  • GC16M084338
  • GC16M084378
  • GC16M083156
  • GC16M070353

Summaries for COTL1 Gene

Entrez Gene Summary for COTL1 Gene

  • This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008]

GeneCards Summary for COTL1 Gene

COTL1 (Coactosin Like F-Actin Binding Protein 1) is a Protein Coding gene. GO annotations related to this gene include enzyme binding and actin binding.

UniProtKB/Swiss-Prot for COTL1 Gene

  • Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.

Gene Wiki entry for COTL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COTL1 Gene

Genomics for COTL1 Gene

Regulatory Elements for COTL1 Gene

Promoters for COTL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COTL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for COTL1 Gene

Chromosome:
16
Start:
84,565,594 bp from pter
End:
84,618,096 bp from pter
Size:
52,503 bases
Orientation:
Minus strand

Genomic View for COTL1 Gene

Genes around COTL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COTL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COTL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COTL1 Gene

Proteins for COTL1 Gene

  • Protein details for COTL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14019-COTL1_HUMAN
    Recommended name:
    Coactosin-like protein
    Protein Accession:
    Q14019
    Secondary Accessions:
    • B2RDU3
    • D3DUL9
    • Q86XM5

    Protein attributes for COTL1 Gene

    Size:
    142 amino acids
    Molecular mass:
    15945 Da
    Quaternary structure:
    • Interacts with 5-lipoxygenase (ALOX5/5LO) in a calcium-independent manner. Binds to F-actin with a stoichiometry of 1:2.

    Three dimensional structures from OCA and Proteopedia for COTL1 Gene

neXtProt entry for COTL1 Gene

Proteomics data for COTL1 Gene at MOPED

Post-translational modifications for COTL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COTL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for COTL1 (Coactosin-like Protein 1/CotL1)

No data available for DME Specific Peptides for COTL1 Gene

Domains & Families for COTL1 Gene

Protein Domains for COTL1 Gene

Suggested Antigen Peptide Sequences for COTL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14019

UniProtKB/Swiss-Prot:

COTL1_HUMAN :
  • Contains 1 ADF-H domain.
  • Belongs to the actin-binding proteins ADF family. Coactosin subfamily.
Domain:
  • Contains 1 ADF-H domain.
Family:
  • Belongs to the actin-binding proteins ADF family. Coactosin subfamily.
genes like me logo Genes that share domains with COTL1: view

No data available for Gene Families for COTL1 Gene

Function for COTL1 Gene

Molecular function for COTL1 Gene

GENATLAS Biochemistry:
rat peroxisomal carnitine octanoyl transferase-like 1
UniProtKB/Swiss-Prot Function:
Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.

Gene Ontology (GO) - Molecular Function for COTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IDA 11583571
genes like me logo Genes that share ontologies with COTL1: view
genes like me logo Genes that share phenotypes with COTL1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for COTL1

miRNA for COTL1 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COTL1 Gene

Localization for COTL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COTL1 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COTL1 Gene COMPARTMENTS Subcellular localization image for COTL1 gene
Compartment Confidence
extracellular 5
cytoskeleton 4
nucleus 4
cytosol 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for COTL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0031965 nuclear membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with COTL1: view

Pathways & Interactions for COTL1 Gene

SuperPathways for COTL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COTL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for COTL1 Gene

Drugs & Compounds for COTL1 Gene

(1) Drugs for COTL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with COTL1: view

Transcripts for COTL1 Gene

Unigene Clusters for COTL1 Gene

Coactosin-like 1 (Dictyostelium):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COTL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b
SP1: - - -
SP2: - - - - -
SP3: - -
SP4: - - -
SP5:

Relevant External Links for COTL1 Gene

GeneLoc Exon Structure for
COTL1
ECgene alternative splicing isoforms for
COTL1

Expression for COTL1 Gene

mRNA expression in normal human tissues for COTL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COTL1 Gene

This gene is overexpressed in Whole Blood (x21.6).

Protein differential expression in normal tissues from HIPED for COTL1 Gene

This gene is overexpressed in Amniocyte (8.1) and Peripheral blood mononuclear cells (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COTL1 Gene



SOURCE GeneReport for Unigene cluster for COTL1 Gene Hs.289092

mRNA Expression by UniProt/SwissProt for COTL1 Gene

Q14019-COTL1_HUMAN
Tissue specificity: Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas.
genes like me logo Genes that share expression patterns with COTL1: view

Protein tissue co-expression partners for COTL1 Gene

Primer Products

In Situ Assay Products

Orthologs for COTL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for COTL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COTL1 35
  • 93.66 (n)
  • 97.18 (a)
COTL1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COTL1 35
  • 94.04 (n)
  • 96.75 (a)
COTL1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cotl1 35
  • 87.79 (n)
  • 95.07 (a)
Cotl1 16
Cotl1 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cotl1 35
  • 89.67 (n)
  • 95.07 (a)
oppossum
(Monodelphis domestica)
Mammalia COTL1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COTL1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COTL1 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves COTL1 35
  • 80.05 (n)
  • 85.21 (a)
COTL1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COTL1 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cotl1 35
  • 71.36 (n)
  • 76.06 (a)
Str.2192 35
African clawed frog
(Xenopus laevis)
Amphibia cotl1-prov 35
zebrafish
(Danio rerio)
Actinopterygii cotl1 35
  • 71.36 (n)
  • 71.13 (a)
wufb08h08 35
cotl1 36
  • 71 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000889 35
  • 54.26 (n)
  • 45.99 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6891 35
  • 54.5 (n)
  • 43.07 (a)
CG6891 36
  • 36 (a)
OneToMany
CG6900 36
  • 38 (a)
OneToMany
Species with no ortholog for COTL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COTL1 Gene

ENSEMBL:
Gene Tree for COTL1 (if available)
TreeFam:
Gene Tree for COTL1 (if available)

Paralogs for COTL1 Gene

Pseudogenes.org Pseudogenes for COTL1 Gene

genes like me logo Genes that share paralogs with COTL1: view

No data available for Paralogs for COTL1 Gene

Variants for COTL1 Gene

Sequence variations from dbSNP and Humsavar for COTL1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs7458 -- 84,565,924(-) CTGTG(C/T)AAGCT utr-variant-3-prime
rs11041 -- 84,565,881(-) CCCGC(C/T)GCGCT utr-variant-3-prime
rs13521 -- 84,566,364(-) TGCCC(A/G)GTGCC utr-variant-3-prime
rs891259 -- 84,604,668(-) TCCAC(C/T)CTGCA intron-variant
rs891260 -- 84,571,223(+) CCCGC(C/G)GCGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COTL1 Gene

Variant ID Type Subtype PubMed ID
nsv907073 CNV Loss 21882294
nsv907076 CNV Gain 21882294
nsv833311 CNV Loss 17160897
nsv907078 CNV Loss 21882294
nsv457605 CNV Loss 19166990
nsv471109 CNV Loss 18288195
nsv907079 CNV Gain 21882294
nsv151 CNV Loss 15895083
nsv1911 CNV Loss 18451855

Variation tolerance for COTL1 Gene

Residual Variation Intolerance Score: 27.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COTL1 Gene

HapMap Linkage Disequilibrium report
COTL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COTL1 Gene

Disorders for COTL1 Gene

Relevant External Links for COTL1

Genetic Association Database (GAD)
COTL1
Human Genome Epidemiology (HuGE) Navigator
COTL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COTL1

No disorders were found for COTL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COTL1 Gene

Publications for COTL1 Gene

  1. Homologous recombination of a flanking repeat gene cluster is a mechanism for a common contiguous gene deletion syndrome. (PMID: 9326934) Chen K.-S. … Lupski J.R. (Nat. Genet. 1997) 2 3 4 67
  2. Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production. (PMID: 16924104) Rakonjac M. … RAYdmark O. (Proc. Natl. Acad. Sci. U.S.A. 2006) 2 3 23
  3. Interaction of 5-lipoxygenase with cellular proteins. (PMID: 10051563) Provost P. … Radmark O. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 23
  4. Coactosin-like protein functions as a stabilizing chaperone for 5- lipoxygenase: role of tryptophan 102. (PMID: 19807693) Esser J. … Radmark O. (Biochem. J. 2010) 3 23
  5. Binding model of human coactosin-like protein with filament actin revealed by mutagenesis. (PMID: 17070122) Dai H. … Shi Y. (Biochim. Biophys. Acta 2006) 3 23

Products for COTL1 Gene

Sources for COTL1 Gene

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