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Aliases for CORT Gene

Aliases for CORT Gene

  • Cortistatin 2 3
  • Prepro-Cortistatin 2 3
  • Preprocortistatin 3
  • Cortistatin-14 3
  • Cortistatin-17 3
  • Cortistatin-29 3
  • CST-14 3
  • CST-17 3
  • CST-29 3

External Ids for CORT Gene

Previous GeneCards Identifiers for CORT Gene

  • GC01P010471
  • GC01P010333
  • GC01P010099
  • GC01P010199
  • GC01P010424
  • GC01P010509
  • GC01P009663

Summaries for CORT Gene

Entrez Gene Summary for CORT Gene

  • This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. [provided by RefSeq, Nov 2010]

GeneCards Summary for CORT Gene

CORT (Cortistatin) is a Protein Coding gene. Diseases associated with CORT include intestinal disease. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include G-protein coupled receptor binding and neuropeptide hormone activity.

UniProtKB/Swiss-Prot for CORT Gene

  • Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs

Gene Wiki entry for CORT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORT Gene

Genomics for CORT Gene

Regulatory Elements for CORT Gene

Genomic Location for CORT Gene

Start:
10,449,719 bp from pter
End:
10,452,003 bp from pter
Size:
2,285 bases
Orientation:
Plus strand

Genomic View for CORT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CORT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORT Gene

Proteins for CORT Gene

  • Protein details for CORT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00230-CORT_HUMAN
    Recommended name:
    Cortistatin
    Protein Accession:
    O00230
    Secondary Accessions:
    • Q5T6G0
    • Q6UX11

    Protein attributes for CORT Gene

    Size:
    105 amino acids
    Molecular mass:
    11532 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI19725.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI19726.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ89950.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19195.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW71650.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CORT Gene

Proteomics data for CORT Gene at MOPED

Post-translational modifications for CORT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CORT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CORT Gene

Domains for CORT Gene

Gene Families for CORT Gene

HGNC:

Protein Domains for CORT Gene

Suggested Antigen Peptide Sequences for CORT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00230

UniProtKB/Swiss-Prot:

CORT_HUMAN :
  • O00230
Family:
  • Belongs to the somatostatin family.
genes like me logo Genes that share domains with CORT: view

Function for CORT Gene

Molecular function for CORT Gene

GENATLAS Biochemistry: preprocortistatin,expressed in GABAergic interneurons in the cerebral cortex and hippocampus,highly homologous to somatostatin,not tumor suppressor for neuroblastoma
UniProtKB/Swiss-Prot Function: Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs

Gene Ontology (GO) - Molecular Function for CORT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IPI 12915402
GO:0005179 hormone activity --
GO:0005184 neuropeptide hormone activity IDA 9125122
genes like me logo Genes that share ontologies with CORT: view
genes like me logo Genes that share phenotypes with CORT: view

Animal Models for CORT Gene

MGI Knock Outs for CORT:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CORT Gene

Localization for CORT Gene

Subcellular locations from UniProtKB/Swiss-Prot for CORT Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CORT Gene COMPARTMENTS Subcellular localization image for CORT gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CORT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space NAS 9125122
genes like me logo Genes that share ontologies with CORT: view

Pathways for CORT Gene

genes like me logo Genes that share pathways with CORT: view

Pathways by source for CORT Gene

Gene Ontology (GO) - Biological Process for CORT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA 9125122
GO:0007268 synaptic transmission NAS 9125122
genes like me logo Genes that share ontologies with CORT: view

Compounds for CORT Gene

(1) HMDB Compounds for CORT Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4

(10) Novoseek inferred chemical compound relationships for CORT Gene

Compound -log(P) Hits PubMed IDs
somatostatin 14 90.2 1
vapreotide 84.7 1
hexarelin 78.8 3
octreotide 60.6 5
acth 44.4 1
genes like me logo Genes that share compounds with CORT: view

Transcripts for CORT Gene

mRNA/cDNA for CORT Gene

(150) Selected AceView cDNA sequences:
(10) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CORT Gene

Cortistatin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CORT Gene

No ASD Table

Relevant External Links for CORT Gene

GeneLoc Exon Structure for
CORT
ECgene alternative splicing isoforms for
CORT

Expression for CORT Gene

mRNA expression in normal human tissues for CORT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CORT Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (10.8), Brain - Caudate (basal ganglia) (9.3), and Brain - Nucleus accumbens (basal ganglia) (5.4).

SOURCE GeneReport for Unigene cluster for CORT Gene Hs.412311

mRNA Expression by UniProt/SwissProt for CORT Gene

O00230-CORT_HUMAN
Tissue specificity: Expressed in a subset of GABAergic cells in the cortex and hippocampus
genes like me logo Genes that share expressions with CORT: view

No data available for Protein expression for CORT Gene

Orthologs for CORT Gene

This gene was present in the common ancestor of mammals.

Orthologs for CORT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CORT 35
  • 98.73 (n)
  • 99.05 (a)
CORT 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CORT 35
  • 81.65 (n)
  • 67.42 (a)
CORT 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cort 35
  • 72.35 (n)
  • 59.09 (a)
Cort 16
Cort 36
  • 51 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CORT 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CORT 36
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cort 35
  • 73.03 (n)
  • 57.3 (a)
Species with no ortholog for CORT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CORT Gene

ENSEMBL:
Gene Tree for CORT (if available)
TreeFam:
Gene Tree for CORT (if available)

Paralogs for CORT Gene

No data available for Paralogs for CORT Gene

Variants for CORT Gene

Structural Variations from Database of Genomic Variants (DGV) for CORT Gene

Variant ID Type Subtype PubMed ID
dgv17e1 CNV Complex 17122850
essv3548 CNV CNV 17122850

Relevant External Links for CORT Gene

HapMap Linkage Disequilibrium report
CORT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CORT Gene

Disorders for CORT Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CORT Gene including...

Search for CORT Gene in MalaCards »

(6) Novoseek inferred disease relationships for CORT Gene

Disease -log(P) Hits PubMed IDs
prolactinoma 64 3
autoimmune diseases 18.4 2
primary tumor 0 2
inflammation 0 2
tumors 0 2

Relevant External Links for CORT

Genetic Association Database (GAD)
CORT
Human Genome Epidemiology (HuGE) Navigator
CORT
genes like me logo Genes that share disorders with CORT: view

No data available for UniProtKB/Swiss-Prot for CORT Gene

Publications for CORT Gene

  1. Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin. (PMID: 9205124) de Lecea L. … Sutcliffe J.G. (Genomics 1997) 2 3 4 23
  2. Identification and characterization of a novel human cortistatin-like peptide. (PMID: 9125122) Fukusumi S. … Fujino M. (Biochem. Biophys. Res. Commun. 1997) 3 4 23
  3. Fine mapping of the human preprocortistatin gene (CORT) to neuroblastoma consensus deletion region 1p36.3-->p36.2, but absence of mutations in primary tumors. (PMID: 10894940) EjeskAor K. … Martinsson T. (Cytogenet. Cell Genet. 2000) 3 23
  4. Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. (PMID: 11011067) Spier A.D. … de Lecea L. (Brain Res. Brain Res. Rev. 2000) 3 23
  5. Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of human pituitary gland. (PMID: 11227737) Deghenghi R. … Muccioli G. (J. Endocrinol. Invest. 2001) 3 23

Products for CORT Gene

Sources for CORT Gene

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