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Aliases for CORT Gene

Aliases for CORT Gene

  • Cortistatin 2 3 3 5
  • Prepro-Cortistatin 2 3
  • Preprocortistatin 3
  • Cortistatin-14 3
  • Cortistatin-17 3
  • Cortistatin-29 3
  • CST-14 3
  • CST-17 3
  • CST-29 3

External Ids for CORT Gene

Previous GeneCards Identifiers for CORT Gene

  • GC01P010471
  • GC01P010333
  • GC01P010099
  • GC01P010199
  • GC01P010424
  • GC01P010509
  • GC01P009663

Summaries for CORT Gene

Entrez Gene Summary for CORT Gene

  • This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. [provided by RefSeq, Nov 2010]

GeneCards Summary for CORT Gene

CORT (Cortistatin) is a Protein Coding gene. Diseases associated with CORT include Neuroblastoma and Intestinal Disease. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include hormone activity and neuropeptide hormone activity.

UniProtKB/Swiss-Prot for CORT Gene

  • Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.

Gene Wiki entry for CORT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORT Gene

Genomics for CORT Gene

Regulatory Elements for CORT Gene

Enhancers for CORT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F010494 1.7 FANTOM5 Ensembl ENCODE 11.6 +47.1 47122 4.9 ATF1 PKNOX1 ARID4B SIN3A DMAP1 BRCA1 ZNF2 ZNF48 YY1 ZNF121 PEX14 DFFA APITD1-CORT CENPS CORT ENSG00000203469 ENSG00000271989 PGD GC01P010513
GH01F010413 1.4 Ensembl ENCODE 12.1 -34.3 -34284 3.1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 ZNF207 PGD UBIAD1 EXOSC10 CORT PEX14 DFFA PIK3CD-AS2 ENSG00000226849 APITD1-CORT CENPS
GH01F010283 0.6 ENCODE 10.1 -166.0 -165960 0.9 ARID1B ZNF362 GATA3 JUND MTA2 IKZF1 NBN KIF1B PGD RNU6-828P CENPS CORT DFFA PEX14 UBE4B GC01P010298 GC01M010233
GH01F010449 1.3 Ensembl ENCODE 0.8 +1.4 1360 2.2 HDGF ATF1 PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF766 GATA2 PGD ENSG00000271989 APITD1-CORT CENPS DFFA PEX14 C1orf127 CORT ENSG00000203469
GH01F010432 0.7 ENCODE 0.3 -16.2 -16215 2.1 SOX13 L3MBTL2 NRF1 MBD2 ZNF335 ZNF366 EGR1 ZNF239 SCRT2 PBX2 PGD ENSG00000271989 CORT
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CORT on UCSC Golden Path with GeneCards custom track

Genomic Location for CORT Gene

Chromosome:
1
Start:
10,449,719 bp from pter
End:
10,452,003 bp from pter
Size:
2,285 bases
Orientation:
Plus strand

Genomic View for CORT Gene

Genes around CORT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORT Gene

Proteins for CORT Gene

  • Protein details for CORT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00230-CORT_HUMAN
    Recommended name:
    Cortistatin
    Protein Accession:
    O00230
    Secondary Accessions:
    • Q5T6G0
    • Q6UX11

    Protein attributes for CORT Gene

    Size:
    105 amino acids
    Molecular mass:
    11532 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI19725.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI19726.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ89950.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19195.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW71650.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CORT Gene

Post-translational modifications for CORT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CORT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CORT Gene

Domains & Families for CORT Gene

Gene Families for CORT Gene

Protein Domains for CORT Gene

Suggested Antigen Peptide Sequences for CORT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00230

UniProtKB/Swiss-Prot:

CORT_HUMAN :
  • Belongs to the somatostatin family.
Family:
  • Belongs to the somatostatin family.
genes like me logo Genes that share domains with CORT: view

Function for CORT Gene

Molecular function for CORT Gene

GENATLAS Biochemistry:
preprocortistatin,expressed in GABAergic interneurons in the cerebral cortex and hippocampus,highly homologous to somatostatin,not tumor suppressor for neuroblastoma
UniProtKB/Swiss-Prot Function:
Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.

Gene Ontology (GO) - Molecular Function for CORT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IPI 12915402
GO:0003682 NOT chromatin binding IBA --
GO:0003690 NOT double-stranded DNA binding IBA --
GO:0005179 hormone activity IEA --
GO:0005184 neuropeptide hormone activity IDA 9125122
genes like me logo Genes that share ontologies with CORT: view
genes like me logo Genes that share phenotypes with CORT: view

Animal Models for CORT Gene

MGI Knock Outs for CORT:

Animal Model Products

  • Taconic Biosciences Mouse Models for CORT

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CORT Gene

Localization for CORT Gene

Subcellular locations from UniProtKB/Swiss-Prot for CORT Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CORT gene
Compartment Confidence
extracellular 5
nucleus 2
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CORT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space NAS 9125122
GO:0043240 NOT Fanconi anaemia nuclear complex IBA --
GO:0071821 NOT FANCM-MHF complex IBA --
genes like me logo Genes that share ontologies with CORT: view

Pathways & Interactions for CORT Gene

genes like me logo Genes that share pathways with CORT: view

SIGNOR curated interactions for CORT Gene

Activates:

Gene Ontology (GO) - Biological Process for CORT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000712 NOT resolution of meiotic recombination intermediates IBA --
GO:0006312 NOT mitotic recombination IBA --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA 9125122
GO:0007268 chemical synaptic transmission NAS 9125122
GO:0031297 NOT replication fork processing IBA --
genes like me logo Genes that share ontologies with CORT: view

Drugs & Compounds for CORT Gene

(9) Drugs for CORT Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0

(2) Additional Compounds for CORT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CORT: view

Transcripts for CORT Gene

mRNA/cDNA for CORT Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(150) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CORT Gene

Cortistatin:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CORT Gene

No ASD Table

Relevant External Links for CORT Gene

GeneLoc Exon Structure for
CORT
ECgene alternative splicing isoforms for
CORT

Expression for CORT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CORT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CORT Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x10.8), Brain - Caudate (basal ganglia) (x9.3), and Brain - Nucleus accumbens (basal ganglia) (x5.4).

NURSA nuclear receptor signaling pathways regulating expression of CORT Gene:

CORT

SOURCE GeneReport for Unigene cluster for CORT Gene:

Hs.412311

mRNA Expression by UniProt/SwissProt for CORT Gene:

O00230-CORT_HUMAN
Tissue specificity: Expressed in a subset of GABAergic cells in the cortex and hippocampus.
genes like me logo Genes that share expression patterns with CORT: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CORT Gene

Orthologs for CORT Gene

This gene was present in the common ancestor of mammals.

Orthologs for CORT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CORT 34 35
  • 98.73 (n)
cow
(Bos Taurus)
Mammalia CORT 34 35
  • 81.65 (n)
rat
(Rattus norvegicus)
Mammalia Cort 34
  • 73.03 (n)
mouse
(Mus musculus)
Mammalia Cort 34 16 35
  • 72.35 (n)
oppossum
(Monodelphis domestica)
Mammalia CORT 35
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CORT 35
  • 43 (a)
OneToOne
Species where no ortholog for CORT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CORT Gene

ENSEMBL:
Gene Tree for CORT (if available)
TreeFam:
Gene Tree for CORT (if available)

Paralogs for CORT Gene

No data available for Paralogs for CORT Gene

Variants for CORT Gene

Sequence variations from dbSNP and Humsavar for CORT Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10746494 -- 10,452,333(+) TCCTG(A/C)GTAGC downstream-variant-500B
rs111936559 -- 10,448,448(+) GCAGG(A/G)CCGGG intron-variant, upstream-variant-2KB
rs113071448 -- 10,448,826(+) AGGCA(A/G)GAGAA intron-variant, upstream-variant-2KB
rs113420083 -- 10,449,463(+) AGGGC(C/T)AGCAG intron-variant, upstream-variant-2KB
rs113805264 -- 10,452,214(+) CAGAA(-/T)TTTTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CORT Gene

Variant ID Type Subtype PubMed ID
esv2758920 CNV gain+loss 17122850
esv2764192 CNV gain 21179565

Variation tolerance for CORT Gene

Residual Variation Intolerance Score: 45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CORT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CORT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CORT Gene

Disorders for CORT Gene

MalaCards: The human disease database

(5) MalaCards diseases for CORT Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma 1
intestinal disease
  • intestinal diseases
separation anxiety disorder
  • separation anxiety disorder of childhood
kleine-levin hibernation syndrome
  • kleine-levin syndrome
recurrent hypersomnia
  • primary recurrent hypersomnia
- elite association - COSMIC cancer census association via MalaCards
Search CORT in MalaCards View complete list of genes associated with diseases

Relevant External Links for CORT

Genetic Association Database (GAD)
CORT
Human Genome Epidemiology (HuGE) Navigator
CORT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CORT
genes like me logo Genes that share disorders with CORT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CORT Gene

Publications for CORT Gene

  1. Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin. (PMID: 9205124) de Lecea L. … Sutcliffe J.G. (Genomics 1997) 2 3 4 22 64
  2. Identification and characterization of a novel human cortistatin-like peptide. (PMID: 9125122) Fukusumi S. … Fujino M. (Biochem. Biophys. Res. Commun. 1997) 3 4 22 64
  3. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PMID: 20398908) Saus E. … Estivill X. (J Psychiatr Res 2010) 3 46 64
  4. Expression of Somatostatin, cortistatin, and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patients. (PMID: 20164562) Gahete M.D. … CastaA+o J.P. (J. Alzheimers Dis. 2010) 3 22 64
  5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 46 64

Products for CORT Gene

Sources for CORT Gene

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