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Aliases for CORT Gene

Aliases for CORT Gene

  • Cortistatin 2 3 5
  • Prepro-Cortistatin 2 3
  • Preprocortistatin 3
  • Cortistatin-14 3
  • Cortistatin-17 3
  • Cortistatin-29 3
  • CST-14 3
  • CST-17 3
  • CST-29 3

External Ids for CORT Gene

Previous GeneCards Identifiers for CORT Gene

  • GC01P010471
  • GC01P010333
  • GC01P010099
  • GC01P010199
  • GC01P010424
  • GC01P010509
  • GC01P009663

Summaries for CORT Gene

Entrez Gene Summary for CORT Gene

  • This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. [provided by RefSeq, Nov 2010]

GeneCards Summary for CORT Gene

CORT (Cortistatin) is a Protein Coding gene. Diseases associated with CORT include Prolactinoma and Intestinal Disease. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include hormone activity and neuropeptide hormone activity.

UniProtKB/Swiss-Prot for CORT Gene

  • Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.

Gene Wiki entry for CORT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORT Gene

Genomics for CORT Gene

Regulatory Elements for CORT Gene

Enhancers for CORT Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CORT on UCSC Golden Path with GeneCards custom track

Genomic Location for CORT Gene

10,449,719 bp from pter
10,452,003 bp from pter
2,285 bases
Plus strand

Genomic View for CORT Gene

Genes around CORT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORT Gene

Proteins for CORT Gene

  • Protein details for CORT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q5T6G0
    • Q6UX11

    Protein attributes for CORT Gene

    105 amino acids
    Molecular mass:
    11532 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI19725.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI19726.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ89950.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI19195.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW71650.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CORT Gene

Proteomics data for CORT Gene at MOPED

Post-translational modifications for CORT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CORT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CORT Gene

Domains & Families for CORT Gene

Gene Families for CORT Gene

Protein Domains for CORT Gene

Suggested Antigen Peptide Sequences for CORT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the somatostatin family.
  • Belongs to the somatostatin family.
genes like me logo Genes that share domains with CORT: view

Function for CORT Gene

Molecular function for CORT Gene

GENATLAS Biochemistry:
preprocortistatin,expressed in GABAergic interneurons in the cerebral cortex and hippocampus,highly homologous to somatostatin,not tumor suppressor for neuroblastoma
UniProtKB/Swiss-Prot Function:
Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.
genes like me logo Genes that share phenotypes with CORT: view

Animal Models for CORT Gene

MGI Knock Outs for CORT:

Animal Model Products

  • Taconic Biosciences Mouse Models for CORT

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CORT Gene

Localization for CORT Gene

Subcellular locations from UniProtKB/Swiss-Prot for CORT Gene


Subcellular locations from

Jensen Localization Image for CORT Gene COMPARTMENTS Subcellular localization image for CORT gene
Compartment Confidence
extracellular 5
nucleus 2
cytoskeleton 1
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CORT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
genes like me logo Genes that share ontologies with CORT: view

Pathways & Interactions for CORT Gene

genes like me logo Genes that share pathways with CORT: view

SIGNOR curated interactions for CORT Gene


Gene Ontology (GO) - Biological Process for CORT Gene


Drugs & Compounds for CORT Gene

(8) Drugs for CORT Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0

(3) Additional Compounds for CORT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CORT: view

Transcripts for CORT Gene

mRNA/cDNA for CORT Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(150) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CORT Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CORT Gene

No ASD Table

Relevant External Links for CORT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CORT Gene

mRNA expression in normal human tissues for CORT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CORT Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x10.8), Brain - Caudate (basal ganglia) (x9.3), and Brain - Nucleus accumbens (basal ganglia) (x5.4).

SOURCE GeneReport for Unigene cluster for CORT Gene Hs.412311

mRNA Expression by UniProt/SwissProt for CORT Gene

Tissue specificity: Expressed in a subset of GABAergic cells in the cortex and hippocampus.
genes like me logo Genes that share expression patterns with CORT: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CORT Gene

Orthologs for CORT Gene

This gene was present in the common ancestor of mammals.

Orthologs for CORT Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CORT 35
  • 81.65 (n)
  • 67.42 (a)
  • 64 (a)
(Mus musculus)
Mammalia Cort 35
  • 72.35 (n)
  • 59.09 (a)
Cort 16
Cort 36
  • 51 (a)
(Pan troglodytes)
Mammalia CORT 35
  • 98.73 (n)
  • 99.05 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Cort 35
  • 73.03 (n)
  • 57.3 (a)
(Monodelphis domestica)
Mammalia CORT 36
  • 45 (a)
(Ornithorhynchus anatinus)
Mammalia CORT 36
  • 43 (a)
Species with no ortholog for CORT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CORT Gene

Gene Tree for CORT (if available)
Gene Tree for CORT (if available)

Paralogs for CORT Gene

No data available for Paralogs for CORT Gene

Variants for CORT Gene

Structural Variations from Database of Genomic Variants (DGV) for CORT Gene

Variant ID Type Subtype PubMed ID
dgv17e1 CNV Complex 17122850
essv3548 CNV CNV 17122850

Variation tolerance for CORT Gene

Residual Variation Intolerance Score: 45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.54% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for CORT Gene

Disorders for CORT Gene

MalaCards: The human disease database

(6) MalaCards diseases for CORT Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • pituitary adenoma, prolactin-secreting
intestinal disease
  • intestinal diseases
  • neuroblastoma 1
separation anxiety disorder
  • separation anxiety disorder of childhood
kleine-levin syndrome
  • kleine levin syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CORT in MalaCards View complete list of genes associated with diseases

Relevant External Links for CORT

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CORT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CORT Gene

Publications for CORT Gene

  1. Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin. (PMID: 9205124) de Lecea L. … Sutcliffe J.G. (Genomics 1997) 2 3 4 23 67
  2. Expression of Somatostatin, cortistatin, and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patients. (PMID: 20164562) Gahete M.D. … CastaA+o J.P. (J. Alzheimers Dis. 2010) 3 23
  3. The role of cortistatin in the human immune system. (PMID: 18450367) van Hagen P.M. … Hofland L.J. (Mol. Cell. Endocrinol. 2008) 3 23
  4. Lowered cortistatin expression is an early event in the human diabetic retina and is associated with apoptosis and glial activation. (PMID: 18709137) Carrasco E. … SimA^ R. (Mol. Vis. 2008) 3 23
  5. Somatostatin molecular variants in the vitreous fluid: a comparative study between diabetic patients with proliferative diabetic retinopathy and nondiabetic control subjects. (PMID: 16043736) HernA!ndez C. … SimA^ R. (Diabetes Care 2005) 3 23

Products for CORT Gene

Sources for CORT Gene