Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CORT Gene

protein-coding   GIFtS: 51
GCID: GC01P010509

cortistatin
 Explore 22 diseases affiliated with
CORT via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CORT    

Aliases
for CORT gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cortistatin1     Cortistatin-141
MGC326861     Cortistatin-171
CST-142     Cortistatin-291
CST-172     Prepro-Cortistatin1
CST-292     Preprocortistatin1

External Ids:    HGNC: 22571   Entrez Gene: 13252   Ensembl: ENSG000002415637   OMIM: 6027845   UniProtKB: O002303   

Export aliases for CORT gene to outside databases

Previous GC identifers: GC01P010471 GC01P010333 GC01P010099 GC01P010199 GC01P010424 GC01P009663


Summaries
for CORT gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CORT:
This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin
receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of
neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave
sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor
activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes
further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream
APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. (provided by RefSeq, Nov
2010)

UniProtKB/Swiss-Prot: CORT_HUMAN, O00230
Function: Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by
forskolin through SSTRs

Gene Wiki entry for CORT (Cortistatin)


Genomic Views
for CORT gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_021937.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CORT gene promoter:
         GR   p53   Pax-6   GR-beta   CUTL1   c-Ets-1   STAT3   GR-alpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CORT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CORT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.22

CORT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CORT gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P010509:  view genomic region     (about GC identifiers)

Start:
 10,509,776 bp from pter      End:
 10,511,959 bp from pter
Size:
 2,184 bases      Orientation:
 plus strand

Proteins
for CORT gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CORT_HUMAN, O00230 (See protein sequence)
Recommended Name: Cortistatin precursor  
Size: 105 amino acids; 11532 Da
Subcellular location: Secreted
Sequence caution: Sequence=AAI19725.1; Type=Erroneous initiation; Sequence=AAI19726.1; Type=Erroneous initiation;
Sequence=AAQ89950.1; Type=Erroneous initiation; Sequence=CAI19195.1; Type=Erroneous initiation; Sequence=EAW71650.1;
Type=Erroneous initiation;
Secondary accessions: Q5T6G0 Q6UX11

Explore the universe of human proteins at neXtProt for CORT: NX_O00230

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O00230

    • CORT Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001293.3  
    ENSEMBL proteins: 
     ENSP00000366248   ENSP00000317110  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: CORT
    OriGene Custom Protein Services for CORT 
    GenScript Custom Purified and Recombinant Proteins Services for CORT
    Novus Biologicals CORT Protein
    Novus Biologicals CORT Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CORT

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space NAS9125122
    GO:0005625soluble fraction ----


    CORT for ontologies           About GeneDecksing



    CORT Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CORT 
    GenScript Superior Antibodies for CORT
    Novus Biologicals CORT Antibody
    Search for Antibodies for CORT at Abcam  
    Uscn Antibodies for CORT
    Search ThermoFisher Antibodies for CORT

    Assay Products for CORT: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CORT
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CORT

    Protein Domains /
    Families
    for CORT gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CORT for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR018142 Somatostatin/Cortistatin_C

    Graphical View of Domain Structure for InterPro Entry O00230

    ProtoNet protein and cluster: O00230

    1 Blocks protein family: IPB004250 Somatostatin/Cortistatin

    UniProtKB/Swiss-Prot: CORT_HUMAN, O00230
    Similarity: Belongs to the somatostatin family


    Function
    for CORT gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CORT_HUMAN, O00230
    Function: Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by
    forskolin through SSTRs

         Genatlas biochemistry entry for CORT:
    preprocortistatin,expressed in GABAergic interneurons in the cerebral cortex and hippocampus,highly homologous to
    somatostatin,not tumor suppressor for neuroblastoma

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CORT
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CORT:
    hsa-miR-374c hsa-miR-655
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CORT (see all 7)
    OriGene shRNA RFP: CORT
    OriGene siRNA: CORT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CORT

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CORT

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CORT (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CORT
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CORT (NM_001302)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CORT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CORT 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CORT
    Search LifeMap BioReagents cell lines for CORT

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORT

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding IPI12915402
    GO:0005184neuropeptide hormone activity IDA9125122


    CORT for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for CORT:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Corttm1Ldl for CORT
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cort):
     behavior/neurological  endocrine/exocrine gland  growth/size  homeostasis/metabolism  normal 

    CORT for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CORT gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CORT

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/6 Interacting proteins for CORT (O002303 ENSP000003171104) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SSTR1P308723I2D: score=1 
    SSTR2P308743I2D: score=1 
    SSTR3P327453I2D: score=1 
    SSTR4P313913I2D: score=1 
    SSTR5P353463I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA9125122
    GO:0007268synaptic transmission NAS9125122


    CORT for ontologies           About GeneDecksing



    Drugs & Compounds
    for CORT gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CORT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CORT

    1 HMDB Compound for CORT    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    10 Novoseek chemical compound relationships for CORT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    somatostatin 14 90.2 1 9650799 (1)
    vapreotide 84.7 1 15855408 (1)
    hexarelin 78.8 3 11227737 (1), 14594107 (1), 11314756 (1)
    octreotide 60.6 5 10219983 (1), 10399028 (1), 15094227 (1), 10374816 (1) (see all 5)
    acth 44.4 1 17893252 (1)
    adenylate 20.4 2 10598790 (1), 15659149 (1)
    acetylcholine 11.3 4 10453467 (1), 9205124 (1), 8622767 (1), 11011067 (1)
    lysine 0 1 10374816 (1)
    glucose 0 1 16625861 (1)
    tyrosine 0 1 18951121 (1)

    Search CenterWatch for drugs/clinical trials and news about CORT 

    Transcripts
    for CORT gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CORT gene: 
    NM_001302.4  

    Unigene Cluster for CORT:

    Cortistatin
    Hs.412311  [show with all ESTs]
    Unigene Representative Sequence: NM_001270517
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377049(uc001ari.3) ENST00000320498

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CORT
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CORT:
    hsa-miR-374c hsa-miR-655
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CORT (see all 7)
    OriGene shRNA RFP: CORT
    OriGene siRNA: CORT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CORT
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CORT (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CORT
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CORT (NM_001302)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CORT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CORT 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CORT
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CORT
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CORT
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CORT

    Additional cDNA sequence: 

    AB000263.1 AF013252.1 AF086433.1 AY358561.1 BC029430.1 BC040034.1 BC119724.1 BC119725.1 
    NR_036462.1 NR_037187.1 

    13 DOTS entries:

    DT.100813917  DT.443038  DT.314859  DT.100027550  DT.121367698  DT.97808227  DT.100023455  DT.121367683 
    DT.75182715  DT.91746558  DT.95260771  DT.95268755  DT.97818062 

    24/150 AceView cDNA sequences (see all 150):

    AI221972 AW244015 BM464479 AF516753 AI304921 BQ012779 NM_199006 NM_001302 
    CA311915 AI479158 AI287304 NM_198544 BE551645 CR593499 AI640354 AI138905 
    AI364233 NM_199295 BQ010739 AI922894 BQ082222 CR593315 AI083637 NM_199294 

    GeneLoc Exon Structure


    Expression
    for CORT gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CORT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTGACTTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CORT expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyAfferent ArterioleJuxtaglomerular CellsKidney, Smooth Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CORT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CORT

    SOURCE GeneReport for Unigene cluster: Hs.412311

    UniProtKB/Swiss-Prot: CORT_HUMAN, O00230
    Tissue specificity: Expressed in a subset of GABAergic cells in the cortex and hippocampus

        SABiosciences Custom PCR Arrays for CORT
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CORT
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CORT
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CORT
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CORT
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORT

    Orthologs
    for CORT gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of human and mouse.

    Orthologs for CORT gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cort1 , 5 cortistatin1, 5 70.75(n)1
    57.14(a)1    		   4 (78.89 cM)5
    128541  NM_007745.31  NP_031771.11 
     1491250345 


    ENSEMBL Gene Tree for CORT (if available)
    TreeFam Gene Tree for CORT (if available) 

    Paralogs
    for CORT gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CORT gene
    APITD12  APITD1-CORT2  

    CORT for paralogs           About GeneDecksing



    Genomic Variants
    for CORT gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/82 NCBI SNPs in CORT are shown (see all 82)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1492083821,2
    		--10507791(+) CAGCAA/CTTTGG 6 -- int1 us2k10--------
    rs778947651,2
    		F--10507821(+) CACGAG/AGTCAG 6 -- int1 us2k11Minor allele frequency- A:0.33NA 6
    rs1433844361,2
    		--10507833(+) AGATCA/GAGACC 6 -- int1 us2k10--------
    rs1877399291,2
    		--10507897(+) CCGGGC/TGTGGT 6 -- int1 us2k10--------
    rs1922412711,2
    		--10507898(+) CGGGCA/GTGGTG 6 -- int1 us2k10--------
    rs1853884971,2
    		--10507991(+) GAGATC/TGAGCC 6 -- us2k1 int10--------
    rs1399594441,2
    		C,--10508023(+) AGAGT-/GAGACTC 6 -- int1 us2k10--------
    rs614500861,2
    		C--10508025(+) AGTGAGA/-CTCCA 6 -- int1 us2k11Minor allele frequency- -:0.00NA 2
    rs1883117131,2
    		--10508047(+) AAAAAA/CCAAAA 6 -- int1 us2k10--------
    rs38280441,2
    		C,F,A,H,--10508136(-) CTTATG/CTTAAA 6 -- us2k1 int131Minor allele frequency- C:0.27EA NA NS WA 3326

    HapMap Linkage Disequilibrium report for CORT (10509776 - 10511959 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CORT
         1 CNV: 3281

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CORT
    DNA2.0 Custom Variant and Variant Library Synthesis for CORT

    Disorders / Diseases
    for CORT gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CORT for disorders           About GeneDecksing

    OMIM gene information: 602784    OMIM disorders: --

    20/22 diseases for CORT (see all 22):    About MalaCards
    growth hormone deficiency    endogenous depression    functioning pituitary adenoma    proliferative diabetic retinopathy
    pituitary adenoma    diabetic retinopathy    prolactinoma    fetal adenoma
    small cell carcinoma    neuronitis    intestinal disease    adenoma
    pituitary tumor    acromegaly    thyroid carcinoma    hepatocellular carcinoma
    alzheimer's disease    thyroiditis    lung cancer    carcinoma

    6 Novoseek disease relationships for CORT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prolactinoma 64 3 16449338 (2), 16595604 (1)
    autoimmune diseases 18.4 2 20030609 (1), 17080202 (1)
    primary tumor 0 2 10894940 (1), 17114908 (1)
    inflammation 0 2 19803425 (1), 17150030 (1)
    tumors 0 3 18276067 (1), 17114908 (1)
    cancer 0 2 19722632 (1), 17114908 (1)

    Human Genome Epidemiology (HuGE) Navigator: CORT (4 documents)

    Export disorders for CORT gene to outside databases

    Publications
    for CORT gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CORT gene, integrated from 9 sources (see all 107):
    (articles sorted by number of sources associating them with CORT)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin. (PubMed id 9205124)1, 2, 3, 9 de Lecea L.... Sutcliffe J.G. (1997)
    2. Identification and characterization of a novel human cortistatin-like peptide. (PubMed id 9125122)1, 2, 9 Fukusumi S.... Fujino M. (1997)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. (PubMed id 11011067)1, 9 Spier A.D. and de Lecea L. (2000)
    5. Fine mapping of the human preprocortistatin gene (CORT) to neuroblastoma consensus deletion region 1p36.3-->p36.2, but absence of mutations in primary tumors. (PubMed id 10894940)1, 9 Ejeskar K....Martinsson T. (2000)
    6. Somatostatin molecular variants in the vitreous fluid: a comparative study between diabetic patients with proliferative diabetic retinopathy and nondiabetic control subjects. (PubMed id 16043736)1, 9 Hernandez C....Simo R. (2005)
    7. Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of human pituitary gland. (PubMed id 11227737)1, 9 Deghenghi R....Muccioli G. (2001)
    8. Expression of Somatostatin, cortistatin, and their re ceptors, as well as dopamine receptors, but not of neprilysin, are reduced in t he temporal lobe of Alzheimer's disease patients. (PubMed id 20164562)1, 9 Gahete M.D....CastaA+o J.P. (2010)
    9. The role of cortistatin in the human immune system. (PubMed id 18450367)1, 9 van Hagen P.M....Hofland L.J. (2008)
    10. Lowered cortistatin expression is an early event in the human diabetic retina and is associated with apoptosis and glial activation. (PubMed id 18709137)1, 9 Carrasco E....Simo R. (2008)

    External Searches for CORT gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CORT gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1325 HGNC: 2257 AceView: CORT Ensembl:ENSG00000241563 euGenes: HUgn1325
    ECgene: CORT H-InvDB: CORT

    Other Databases showing CORT gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CORT gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CORT Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CORT gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CORT gene:
    Search GeneIP for patents involving CORT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CORT gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for CORT  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CORT   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CORT  
     OriGene Protein Over-expression Lysate for CORT   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CORT   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CORT   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CORT  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CORT   OriGene Custom Protein Services for CORT  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CORT
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CORT
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CORT
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CORT
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CORT
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CORT
     GenScript Custom Purified and Recombinant Proteins Services for CORT GenScript cDNA clones with any tag delivered in your preferred vector for CORT
     GenScript Custom Assay Services for CORT GenScript Superior Antibodies for CORT
     GenScript Custom overexpressing Cell Line Services for CORT CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CORT promoter
     Search Chromatin IP Primers for CORT
     RT2 qPCR Primer Assay in human, mouse, rat CORT
     GNC Network for CORT
     SABiosciences Custom PCR Arrays for CORT
     Search Tocris compounds for CORT
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CORT antibodies
     CORT proteins
     CORT lysates
     Search for Antibodies for CORT at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CORT
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CORT Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CORT
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORT
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CORT
     Browse SwitchGear Promoter luciferase reporter plasmids for CORT
     Search ThermoFisher Antibodies for CORT
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CORT
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CORT gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4