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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CORT Gene

protein-coding   GIFtS: 52
GCID: GC01P010509

Cortistatin

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
cortistatin1 2     cortistatin-142
prepro-cortistatin1 2     cortistatin-172
CST-142     cortistatin-292
CST-172     preprocortistatin2
CST-292     

External Ids:    HGNC: 22571   Entrez Gene: 13252   Ensembl: ENSG000002415637   OMIM: 6027845   UniProtKB: O002303   

Export aliases for CORT gene to outside databases

Previous GC identifers: GC01P010471 GC01P010333 GC01P010099 GC01P010199 GC01P010424 GC01P009663


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CORT Gene:
This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin
receptors, and shares many pharmacological and functional properties with somatostatin, including the depression
of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of
slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of
locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein
undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and
the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. (provided
by RefSeq, Nov 2010)

GeneCards Summary for CORT Gene: 
CORT (cortistatin) is a protein-coding gene. Diseases associated with CORT include fetal adenoma, and endogenous depression. GO annotations related to this gene include neuropeptide hormone activity and G-protein coupled receptor binding.

UniProtKB/Swiss-Prot: CORT_HUMAN, O00230
Function: Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by
forskolin through SSTRs

Gene Wiki entry for CORT (Cortistatin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_021937.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CORT gene promoter:
         GR   p53   Pax-6   GR-beta   CUTL1   c-Ets-1   STAT3   GR-alpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CORT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CORT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.22

CORT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CORT gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P010509:  view genomic region     (about GC identifiers)

Start:
10,509,776 bp from pter      End:
10,512,060 bp from pter
Size:
2,285 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CORT_HUMAN, O00230 (See protein sequence)
Recommended Name: Cortistatin precursor  
Size: 105 amino acids; 11532 Da
Subcellular location: Secreted
Sequence caution: Sequence=AAI19725.1; Type=Erroneous initiation; Sequence=AAI19726.1; Type=Erroneous initiation;
Sequence=AAQ89950.1; Type=Erroneous initiation; Sequence=CAI19195.1; Type=Erroneous initiation;
Sequence=EAW71650.1; Type=Erroneous initiation;
Secondary accessions: Q5T6G0 Q6UX11

Explore the universe of human proteins at neXtProt for CORT: NX_O00230

Explore proteomics data for CORT at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00230

  • CORT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CORT Protein Expression
    REFSEQ proteins: NP_001293.3  
    ENSEMBL proteins: 
     ENSP00000366248   ENSP00000317110  

    Human Recombinant Protein Products for CORT: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for CORT
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CORT
    GenScript Custom Purified and Recombinant Proteins Services for CORT
    Novus Biologicals CORT Protein
    Novus Biologicals CORT Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CORT 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space NAS9125122

    CORT for ontologies           About GeneDecksing



    CORT Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for CORT 

    Assay Products for CORT: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CORT
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CORT 
    Cloud-Clone Corp. CLIAs for CORT


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    1 InterPro protein domain:
     IPR018142 Somatostatin/Cortistatin_C

    Graphical View of Domain Structure for InterPro Entry O00230

    ProtoNet protein and cluster: O00230

    1 Blocks protein domain: IPB004250 Somatostatin/Cortistatin

    UniProtKB/Swiss-Prot: CORT_HUMAN, O00230
    Similarity: Belongs to the somatostatin family


    CORT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CORT_HUMAN, O00230
    Function: Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by
    forskolin through SSTRs

         Genatlas biochemistry entry for CORT:
    preprocortistatin,expressed in GABAergic interneurons in the cerebral cortex and hippocampus,highly homologous to
    somatostatin,not tumor suppressor for neuroblastoma

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding IPI12915402
    GO:0005179hormone activity ----
    GO:0005184neuropeptide hormone activity IDA9125122
         
    CORT for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CORT:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cort):
     behavior/neurological  endocrine/exocrine gland  growth/size  homeostasis/metabolism  normal 

    CORT for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Corttm1Ldl for CORT

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CORT 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CORT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CORT 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CORT 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CORT
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CORT:
    hsa-miR-374c hsa-miR-655
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CORT (NM_001302)
    Sino Biological Human cDNA Clone for CORT
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CORT
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                         Customized lentivirus expression plasmids for stable overexpression of CORT 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORT


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CORT

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/6 Interacting proteins for CORT (O002303 ENSP000003171104) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SSTR1P308723I2D: score=1 
    SSTR2P308743I2D: score=1 
    SSTR3P327453I2D: score=1 
    SSTR4P313913I2D: score=1 
    SSTR5P353463I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA9125122
    GO:0007268synaptic transmission NAS9125122

    CORT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CORT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CORT

    1 HMDB Compound for CORT    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    10 Novoseek inferred chemical compound relationships for CORT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    somatostatin 14 90.2 1 9650799 (1)
    vapreotide 84.7 1 15855408 (1)
    hexarelin 78.8 3 11227737 (1), 14594107 (1), 11314756 (1)
    octreotide 60.6 5 10219983 (1), 10399028 (1), 15094227 (1), 10374816 (1) (see all 5)
    acth 44.4 1 17893252 (1)
    adenylate 20.4 2 10598790 (1), 15659149 (1)
    acetylcholine 11.3 4 10453467 (1), 9205124 (1), 8622767 (1), 11011067 (1)
    lysine 0 1 10374816 (1)
    glucose 0 1 16625861 (1)
    tyrosine 0 1 18951121 (1)

    Search CenterWatch for drugs/clinical trials and news about CORT

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CORT gene: 
    NM_001302.4  

    Unigene Cluster for CORT:

    Cortistatin
    Hs.412311  [show with all ESTs]
    Unigene Representative Sequence: NM_001270517
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377049(uc001ari.3) ENST00000320498

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CORT
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CORT:
    hsa-miR-374c hsa-miR-655
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CORT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CORT
    Clone
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    OriGene clones in human, mouse for CORT (see all 6)
    OriGene ORF clones in mouse, rat for CORT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CORT (NM_001302)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CORT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CORT
    Sirion Biotech Customized lentivirus for stable overexpression of CORT 
                         Customized lentivirus expression plasmids for stable overexpression of CORT 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CORT
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CORT

    Additional mRNA sequence: 

    AB000263.1 AF013252.1 AF086433.1 AY358561.1 BC029430.1 BC040034.1 BC119724.1 BC119725.1 
    NR_036462.1 NR_037187.1 

    13 DOTS entries:

    DT.100813917  DT.443038  DT.314859  DT.100027550  DT.121367698  DT.97808227  DT.100023455  DT.121367683 
    DT.75182715  DT.91746558  DT.95260771  DT.95268755  DT.97818062 

    24/150 AceView cDNA sequences (see all 150):

    BE551645 NM_198544 NM_001302 AI304921 AI364233 AF516753 AI221972 BM464479 
    NM_199294 AI640354 AI083637 CR593499 BQ012779 NM_199295 CA311915 AI922894 
    NM_199006 AI287304 BQ010739 AI479158 AI138905 CR593315 AW244015 BQ082222 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CORT expression in normal human tissues (normalized intensities)      CORT embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTGACTTTT
    CORT Expression
    About this image


    CORT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
             Midbrain   
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Kidney (Urinary System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Spinal Cord (Nervous System)
             Dorsal Horn   

    See CORT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CORT

    SOURCE GeneReport for Unigene cluster: Hs.412311

    UniProtKB/Swiss-Prot: CORT_HUMAN, O00230
    Tissue specificity: Expressed in a subset of GABAergic cells in the cortex and hippocampus

        SABiosciences Custom PCR Arrays for CORT
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CORT gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cort1 , 5 cortistatin1, 5 70.75(n)1
    57.14(a)1
      4 (78.89 cM)5
    128541  NM_007745.31  NP_031771.11 
     1491250345 
    chicken
    (Gallus gallus)
    Aves APITD16
    Centromere protein S
    3(a)
    1 → many
    21(3730260-3733060)
    zebrafish
    (Danio rerio)
    Actinopterygii CORT6
    cortistatin
    2(a)
    1 → many
    6(45871908-45874184)


    ENSEMBL Gene Tree for CORT (if available)
    TreeFam Gene Tree for CORT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CORT:    About this table     
    Variant IDTypeSubtypePubMed ID
    essv3548CNV CNV17122850
    dgv17e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CORT
    DNA2.0 Custom Variant and Variant Library Synthesis for CORT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602784    OMIM disorders: --

    20/22 diseases for CORT (see all 22):    About MalaCards
    fetal adenoma    endogenous depression    prolactinoma    intestinal disease
    functioning pituitary adenoma    non-functioning pituitary adenoma    growth hormone deficiency    small cell carcinoma
    proliferative diabetic retinopathy    acromegaly    diabetic retinopathy    pituitary adenoma
    pituitary tumors    adenoma    neuroblastoma    cerebritis
    thyroiditis    alzheimer's disease    hepatocellular carcinoma    lung cancer


    CORT for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    6 Novoseek inferred disease relationships for CORT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prolactinoma 64 3 16449338 (2), 16595604 (1)
    autoimmune diseases 18.4 2 20030609 (1), 17080202 (1)
    primary tumor 0 2 10894940 (1), 17114908 (1)
    inflammation 0 2 19803425 (1), 17150030 (1)
    tumors 0 3 18276067 (1), 17114908 (1)
    cancer 0 2 19722632 (1), 17114908 (1)

    Genetic Association Database (GAD): CORT
    Human Genome Epidemiology (HuGE) Navigator: CORT (4 documents)

    Export disorders for CORT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CORT gene, integrated from 9 sources (see all 108):
    (articles sorted by number of sources associating them with CORT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin. (PubMed id 9205124)1, 2, 3, 9 de Lecea L.... Sutcliffe J.G. (1997)
    2. Identification and characterization of a novel human cortistatin-like peptide. (PubMed id 9125122)1, 2, 9 Fukusumi S.... Fujino M. (1997)
    3. Comprehensive copy number variant (CNV) analysis of n euronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (2010)
    4. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. (PubMed id 11011067)1, 9 Spier A.D. and de Lecea L. (2000)
    7. Fine mapping of the human preprocortistatin gene (CORT) to neuroblastoma consensus deletion region 1p36.3-->p36.2, but absence of mutations in primary tumors. (PubMed id 10894940)1, 9 Ejeskar K....Martinsson T. (2000)
    8. Somatostatin molecular variants in the vitreous fluid: a comparative study between diabetic patients with proliferative diabetic retinopathy and nondiabetic control subjects. (PubMed id 16043736)1, 9 Hernandez C....Simo R. (2005)
    9. Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of human pituitary gland. (PubMed id 11227737)1, 9 Deghenghi R....Muccioli G. (2001)
    10. Expression of Somatostatin, cortistatin, and their re ceptors, as well as dopamine receptors, but not of neprilysin, are reduced in t he temporal lobe of Alzheimer's disease patients. (PubMed id 20164562)1, 9 Gahete M.D....CastaA+o J.P. (2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1325 HGNC: 2257 AceView: CORT Ensembl:ENSG00000241563 euGenes: HUgn1325
    ECgene: CORT H-InvDB: CORT

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for CORT Pharmacogenomics, SNPs, Pathways

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