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CORO7-PAM16 Gene

protein-coding   GIFtS: 25
GCID: GC16M004392

CORO7-PAM16 Readthrough

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CORO7-PAM16 Readthrough1 2
CORO7-PAM16 Protein2

External Ids:    HGNC: 444241   Entrez Gene: 1005291442   Ensembl: ENSG000001034267   UniProtKB: I3L1674   

Export aliases for CORO7-PAM16 gene to outside databases

Previous GC identifer: GC16U901294


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CORO7-PAM16 Gene:
This locus represents naturally occurring read-through transcription between the neighboring CORO7 (coronin 7) and
PAM16 (presequence translocase-associated motor 16) genes on chromosome 16. The read-through transcript encodes a
fusion protein that shares sequence identity with each individual gene product. (provided by RefSeq, Jan 2011)

GeneCards Summary for CORO7-PAM16 Gene:
CORO7-PAM16 (CORO7-PAM16 readthrough) is a protein-coding gene. Diseases associated with CORO7-PAM16 include malaria. An important paralog of this gene is CORO1B.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for CORO7-PAM16
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CORO7-PAM16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CORO7-PAM16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

CORO7-PAM16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CORO7-PAM16 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M004392:  view genomic region     (about GC identifiers)

Start:
4,390,252 bp from pter      End:
4,470,495 bp from pter
Size:
80,244 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/TrEMBL: I3L167 (See protein sequence)
Recommended Name: Coronin  
Size: 535 amino acids; 57677 Da

REFSEQ proteins: NP_001188408.1  
ENSEMBL proteins: 
 ENSP00000460885   ENSP00000458607  

CORO7-PAM16 Human Recombinant Protein Products:

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CORO7-PAM16 Assay Products:

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Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Selected InterPro protein domains (see all 6):
 IPR015049 DUF1900
 IPR027331 CORO7
 IPR001680 WD40_repeat
 IPR015505 Coronin
 IPR017986 WD40_repeat_dom

Graphical View of Domain Structure for InterPro Entry I3L167

ProtoNet protein and cluster: I3L167

UniProtKB/TrEMBL: I3L167
Similarity: Belongs to the WD repeat coronin family
Similarity: Contains 4 WD repeats


CORO7-PAM16 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
CORO7-PAM16 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for CORO7-PAM16:
 G0/1 arrest  Increased G1 DNA content 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CORO7-PAM16
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CORO7-PAM16
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CORO7-PAM16

miRNA
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Cell Line
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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005794Golgi apparatus ----

CORO7-PAM16 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CORO7-PAM16
Interactions:

    Search GeneGlobe Interaction Network for CORO7-PAM16

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CORO7-PAM16



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CORO7-PAM16 gene: 
NM_001201479.1  

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000572467 ENST00000575334(uc002cwe.3 uc002cwf.3 uc010uxj.1 uc010btp.1)
ENST00000572274
miRNA
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Predesigned siRNA for gene silencing in human, mouse, rat CORO7-PAM16
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Primer
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GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for CORO7-PAM16 (see all 21)    About this scheme

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10a · 10b · 10c ^
SP1:                                      -     -     -     -     -     -           -                                                                           
SP2:                                                              -     -           -                                         -     -     -                     
SP3:                                                                                                                                                            
SP4:                                      -     -     -     -     -     -           -                                   -     -     -     -     -     -     -   
SP5:                                      -     -     -     -     -     -           -                                         -     -     -                     

ExUns: 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a ·
SP1:                                                              -           -                 -     -                                                         
SP2:                                                              -           -                 -     -                                                         
SP3:                                                                                            -     -                                                         
SP4:  -     -                                                                                                                                                   
SP5:                                                                                                                                                            

ExUns: 30b ^ 31 ^ 32a · 32b ^ 33 ^ 34a · 34b · 34c
SP1:                    -                           
SP2:                    -                           
SP3:                                                
SP4:                                                
SP5:                                                


ECgene alternative splicing isoforms for CORO7-PAM16

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

CORO7-PAM16 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
    Custom PCR Arrays for CORO7-PAM16
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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORO7-PAM16

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for CORO7-PAM16 gene from Selected species (see all 16)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Coro71 coronin 7 81.47(n)
84.8(a)
  78885  NM_030205.4  NP_084481.3 
chicken
(Gallus gallus)
Aves CORO71 coronin 7 68.89(n)
67.58(a)
  416670  NM_001006176.1  NP_001006176.1 
lizard
(Anolis carolinensis)
Reptilia --
Coronin
66(a)
1 → many
GL343856.1(20064-38818)
tropical clawed frog
(Xenopus tropicalis)
Amphibia coro71 coronin 7 60.85(n)
57.24(a)
  100492934  XM_002932462.2  XP_002932508.2 
zebrafish
(Danio rerio)
Actinopterygii coro71 coronin 7 61.81(n)
57.24(a)
  569563  NM_001030236.1  NP_001025407.1 
fruit fly
(Drosophila melanogaster)
Insecta pod11 pod1 51.29(n)
42.27(a)
  31620  NM_167092.2  NP_727126.1 
worm
(Caenorhabditis elegans)
Secernentea pod-11 pod-1 45.94(n)
34.69(a)
  176784  NM_067396.5  NP_499797.1 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRN16
Coronin, cortical actin cytoskeletal component tha...
21(a)
1 → many
XII(990777-992732) YLR429W


ENSEMBL Gene Tree for CORO7-PAM16 (if available)
TreeFam Gene Tree for CORO7-PAM16 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CORO7-PAM16 gene
CORO71 2  CORO1B2  CORO1A2  CORO62  CORO1C2  CORO2B2  CORO2A2  
5 SIMAP similar genes for CORO7-PAM16 using alignment to 1 protein entry:     I3L167_HUMAN:
CORO7    CORO1C    CORO6    CORO1A    CORO1B

CORO7-PAM16 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CORO7-PAM16 (see all 15)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs71882261,2
C--4403406(+) cctccC/Tgaagt 1 -- int10--------
rs1922605621,2
--4403459(+) GTATTA/CTTTGT 1 -- int10--------
rs1135705401,2
F--4403534(+) CACCTC/TGGCCT 1 -- int12Minor allele frequency- T:0.50CSA 4
rs5829531,2
C,H--4403600(-) CCCAAC/AAGGAA 1 -- int115Minor allele frequency- A:0.00NS EA NA WA CSA 521
rs1490977071,2
--4403615(+) CATTTC/TCTCTC 1 -- int10--------
rs1430748301,2
C--4403646(+) CAAGCA/GCCTGG 1 -- int10--------
rs80518311,2
C,F,A,H--4403664(+) tctggC/Tgcaca 1 -- int123Minor allele frequency- T:0.16NS EA NA WA 2756
rs1834520131,2
--4403691(+) GGGATA/GAAAGT 1 -- int10--------
rs1387596531,2
--4403724(+) TACACA/CGCTGC 1 -- int10--------
rs1149961711,2
F--4403739(+) CTTCCT/CCTTCC 1 -- int11Minor allele frequency- C:0.01WA 118

HapMap Linkage Disequilibrium report for CORO7-PAM16 (4390252 - 4470495 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for CORO7-PAM16 (see all 17):    About this table    
Variant IDTypeSubtypePubMed ID
esv2667108CNV Deletion23128226
esv2659570CNV Deletion23128226
esv1211300CNV Insertion17803354
esv1548790CNV Insertion17803354
nsv471075CNV Loss18288195
nsv905222CNV Loss21882294
nsv527866CNV Loss19592680
nsv905224CNV Loss21882294
nsv905233CNV Loss21882294
nsv103783CNV Loss16902084

Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing CORO7-PAM16
DNA2.0 Custom Variant and Variant Library Synthesis for CORO7-PAM16

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for CORO7-PAM16:    
About MalaCards
malaria


CORO7-PAM16 for disorders           About GeneDecksing


Export disorders for CORO7-PAM16 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CORO7-PAM16 gene integrated from 10 sources:
(articles sorted by number of sources associating them with CORO7-PAM16)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
  2. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
  3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
  6. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100529144 HGNC: 44424 Ensembl:ENSG00000103426 euGenes: HUgn100529144 ECgene: CORO7-PAM16
H-InvDB: CORO7-PAM16

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CORO7-PAM16 gene:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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