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Aliases for CORO7-PAM16 Gene

Aliases for CORO7-PAM16 Gene

  • CORO7-PAM16 Readthrough 2 3 5

External Ids for CORO7-PAM16 Gene

Previous GeneCards Identifiers for CORO7-PAM16 Gene

  • GC16U901294
  • GC16M004392

Summaries for CORO7-PAM16 Gene

Entrez Gene Summary for CORO7-PAM16 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring CORO7 (coronin 7) and PAM16 (presequence translocase-associated motor 16) genes on chromosome 16. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jan 2011]

GeneCards Summary for CORO7-PAM16 Gene

CORO7-PAM16 (CORO7-PAM16 Readthrough) is a Protein Coding gene. An important paralog of this gene is CORO7.

Additional gene information for CORO7-PAM16 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORO7-PAM16 Gene

Genomics for CORO7-PAM16 Gene

Regulatory Elements for CORO7-PAM16 Gene

Enhancers for CORO7-PAM16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H004407 1.7 FANTOM5 ENCODE dbSUPER 0.4 +8.0 7958 10 HDGF PKNOX1 ARID4B SIN3A FEZF1 SLC30A9 ZNF143 FOS SP3 MXD4 NMRAL1 CORO7 HMOX2 MGRN1 NUDT16L1 CORO7-PAM16 VASN
GH16H004402 1.2 Ensembl ENCODE 0.4 +17.6 17612 1 HDGF PKNOX1 ATF1 ARID4B SIN3A ZNF2 ZNF143 ATF7 REST PPARG NMRAL1 CORO7-PAM16 VASN
GH16H004404 1.1 ENCODE dbSUPER 0.4 +15.8 15755 0 HDGF CTCF PKNOX1 KLF17 SIN3A SALL2 ZIC2 ZNF2 RAD21 ZFHX2 CDIP1 CLUAP1 NMRAL1 ANKS3 CORO7-PAM16 VASN
GH16H004391 1.3 Ensembl ENCODE dbSUPER 0.3 +26.9 26851 4 KLF1 NFIB SIN3A ZIC2 ETS1 ZFHX2 ELK1 POLR2A ZNF600 RCOR1 NMRAL1 HMOX2 VASN PAM16 MGRN1 CORO7-PAM16
GH16H004368 1.9 FANTOM5 Ensembl ENCODE dbSUPER 0.2 +46.2 46186 10 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS SP3 SP5 NMRAL1 ANKS3 CREBBP ZNF500 ZSCAN32 ZNF174 HMOX2 CLUAP1 ENSG00000261938 MGRN1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CORO7-PAM16 on UCSC Golden Path with GeneCards custom track

Genomic Location for CORO7-PAM16 Gene

Chromosome:
16
Start:
4,340,251 bp from pter
End:
4,420,494 bp from pter
Size:
80,244 bases
Orientation:
Minus strand

Genomic View for CORO7-PAM16 Gene

Genes around CORO7-PAM16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORO7-PAM16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORO7-PAM16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO7-PAM16 Gene

Proteins for CORO7-PAM16 Gene

  • Protein details for CORO7-PAM16 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A6YYL4
    Recommended name:
    Coronin
    Protein Accession:
    A0A0A6YYL4

    Protein attributes for CORO7-PAM16 Gene

    Size:
    1048 amino acids
    Molecular mass:
    114166 Da
    Quaternary structure:
    No Data Available
  • Protein details for CORO7-PAM16 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    I3L167
    Recommended name:
    Coronin
    Protein Accession:
    I3L167

    Protein attributes for CORO7-PAM16 Gene

    Size:
    535 amino acids
    Molecular mass:
    57677 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CORO7-PAM16 Gene

Post-translational modifications for CORO7-PAM16 Gene

No Post-translational modifications

Other Protein References for CORO7-PAM16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CORO7-PAM16 Gene

Domains & Families for CORO7-PAM16 Gene

Gene Families for CORO7-PAM16 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CORO7-PAM16: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CORO7-PAM16 Gene

Function for CORO7-PAM16 Gene

Phenotypes From GWAS Catalog for CORO7-PAM16 Gene

Phenotypes for CORO7-PAM16 Gene

MGI mutant phenotypes for CORO7-PAM16:
inferred from 1 alleles
GenomeRNAi human phenotypes for CORO7-PAM16:
genes like me logo Genes that share phenotypes with CORO7-PAM16: view

Animal Models for CORO7-PAM16 Gene

MGI Knock Outs for CORO7-PAM16:

Animal Model Products

miRNA for CORO7-PAM16 Gene

miRTarBase miRNAs that target CORO7-PAM16

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CORO7-PAM16 Gene

Localization for CORO7-PAM16 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CORO7-PAM16 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Microtubules (1)
  • Nucleoplasm (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CORO7-PAM16 Gene

Pathways & Interactions for CORO7-PAM16 Gene

SuperPathways for CORO7-PAM16 Gene

No Data Available

Interacting Proteins for CORO7-PAM16 Gene

Gene Ontology (GO) - Biological Process for CORO7-PAM16 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CORO7-PAM16 Gene

Drugs & Compounds for CORO7-PAM16 Gene

No Compound Related Data Available

Transcripts for CORO7-PAM16 Gene

mRNA/cDNA for CORO7-PAM16 Gene

(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CORO7-PAM16 Gene

No ASD Table

Relevant External Links for CORO7-PAM16 Gene

GeneLoc Exon Structure for
CORO7-PAM16
ECgene alternative splicing isoforms for
CORO7-PAM16

Expression for CORO7-PAM16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CORO7-PAM16 Gene

This gene is overexpressed in NK cells (14.8) and Lymph node (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from PaxDb and MOPED for CORO7-PAM16 Gene



Protein tissue co-expression partners for CORO7-PAM16 Gene

genes like me logo Genes that share expression patterns with CORO7-PAM16: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CORO7-PAM16 Gene

Orthologs for CORO7-PAM16 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CORO7-PAM16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 99 (a)
OneToMany
CORO7 33
  • 97.06 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 87 (a)
OneToMany
CORO7 33
  • 86.04 (n)
cow
(Bos Taurus)
Mammalia CORO7 33 34
  • 86.43 (n)
mouse
(Mus musculus)
Mammalia Coro7 33 16 34
  • 81.47 (n)
rat
(Rattus norvegicus)
Mammalia Coro7 33
  • 80.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 75 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 72 (a)
OneToMany
chicken
(Gallus gallus)
Aves CORO7 33 34
  • 68.89 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 66 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia coro7 33
  • 60.85 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01076758.1 34
  • 67 (a)
ManyToMany
coro7 33 34
  • 61.81 (n)
fruit fly
(Drosophila melanogaster)
Insecta pod1 33 34
  • 51.29 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000930 33
  • 43.86 (n)
worm
(Caenorhabditis elegans)
Secernentea pod-1 34 33
  • 45.94 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRN1 34
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
OneToMany
Species where no ortholog for CORO7-PAM16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CORO7-PAM16 Gene

ENSEMBL:
Gene Tree for CORO7-PAM16 (if available)
TreeFam:
Gene Tree for CORO7-PAM16 (if available)

Paralogs for CORO7-PAM16 Gene

Paralogs for CORO7-PAM16 Gene

(5) SIMAP similar genes for CORO7-PAM16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CORO7-PAM16: view

Variants for CORO7-PAM16 Gene

Sequence variations from dbSNP and Humsavar for CORO7-PAM16 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs786203989 Pathogenic 4,340,985(-) TGCAG(A/G)ACTAT reference, missense
rs864309494 Uncertain significance 4,355,236(-) TCGCA(C/T)ATGCC intron-variant
rs1000072235 -- 4,344,003(+) TGGTC(C/T)CTGCC intron-variant
rs1000088603 -- 4,348,904(+) CACCC(A/G)AAGTG intron-variant
rs1000093995 -- 4,411,979(+) GGCCC(C/T)GAGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CORO7-PAM16 Gene

Variant ID Type Subtype PubMed ID
esv1211300 CNV insertion 17803354
esv1548790 CNV insertion 17803354
esv23732 CNV gain 19812545
esv2659570 CNV deletion 23128226
esv2667108 CNV deletion 23128226
esv3335033 CNV duplication 20981092
esv3584924 CNV gain 24956385
esv3637695 CNV loss 21293372
esv3637696 CNV loss 21293372
nsv103783 CNV deletion 16902084
nsv1046986 CNV gain 25217958
nsv1160332 CNV duplication 26073780
nsv471075 CNV loss 18288195
nsv475644 CNV novel sequence insertion 20440878
nsv520212 CNV loss 19592680
nsv527866 CNV loss 19592680
nsv571274 CNV gain 21841781
nsv571301 CNV gain+loss 21841781
nsv833132 CNV loss 17160897

Variation tolerance for CORO7-PAM16 Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.98; 60.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CORO7-PAM16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CORO7-PAM16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CORO7-PAM16 Gene

Disorders for CORO7-PAM16 Gene

Relevant External Links for CORO7-PAM16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CORO7-PAM16

No disorders were found for CORO7-PAM16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CORO7-PAM16 Gene

Publications for CORO7-PAM16 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for CORO7-PAM16 Gene

Sources for CORO7-PAM16 Gene

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