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Aliases for CORO7 Gene

Aliases for CORO7 Gene

  • Coronin 7 2 3
  • CRN7 3 4 6
  • 70 KDa WD Repeat Tumor Rejection Antigen Homolog 3 4
  • POD1 3 6
  • 0610011B16Rik 3
  • Coronin-7 3

External Ids for CORO7 Gene

Summaries for CORO7 Gene

Entrez Gene Summary for CORO7 Gene

  • Coronins, such as CORO7, constitute an evolutionarily conserved family of WD-repeat actin-binding proteins. CORO7 plays a role in Golgi complex morphology and function (Rybakin et al., 2004, 2006 [PubMed 15327992] [PubMed 16905771]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CORO7 Gene

CORO7 (Coronin 7) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Mitochondrial Protein Import. An important paralog of this gene is CORO6.

UniProtKB/Swiss-Prot for CORO7 Gene

  • F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via Lys-33-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORO7 Gene

Genomics for CORO7 Gene

Genomic Location for CORO7 Gene

Start:
4,354,542 bp from pter
End:
4,425,705 bp from pter
Size:
71,164 bases
Orientation:
Minus strand

Genomic View for CORO7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CORO7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO7 Gene

Regulatory Elements for CORO7 Gene

Proteins for CORO7 Gene

  • Protein details for CORO7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57737-CORO7_HUMAN
    Recommended name:
    Coronin-7
    Protein Accession:
    P57737
    Secondary Accessions:
    • B4DFD6
    • B4DL18
    • I3L416
    • Q17RK4

    Protein attributes for CORO7 Gene

    Size:
    925 amino acids
    Molecular mass:
    100605 Da
    Quaternary structure:
    • Interacts with clathrin adapter AP1 complex. This interaction takes place at Golgi membranes and not AP1-positive endosomal membranes. Interacts (when ubiquitinated at Lys-472) with EPS15.

    Alternative splice isoforms for CORO7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CORO7 Gene

Proteomics data for CORO7 Gene at MOPED

Post-translational modifications for CORO7 Gene

  • The membrane-associated form is phosphorylated on tyrosine residues.
  • Ubiquitinated via Lys-33-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex: Lys-33-linked ubiquitination promotes interaction with EPS15 and facilitates actin polymerization at the trans-Golgi network, thereby facilitating post-Golgi trafficking. Deubiquitinated by ZRANB1/TRABID.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys157, Lys348, Lys472, Lys491, Lys508, Lys596, Lys680, and Lys903

No data available for DME Specific Peptides for CORO7 Gene

Domains for CORO7 Gene

Gene Families for CORO7 Gene

HGNC:
  • WDR :WD repeat domain containing
  • CORO :Coronins

UniProtKB/Swiss-Prot:

CORO7_HUMAN
Family:
  • Belongs to the WD repeat coronin family.:
    • P57737
Similarity:
  • Contains 8 WD repeats.:
    • P57737
genes like me logo Genes that share domains with CORO7: view

Function for CORO7 Gene

Molecular function for CORO7 Gene

UniProtKB/Swiss-Prot Function: F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via Lys-33-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.

Gene Ontology (GO) - Molecular Function for CORO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IDA 24768539
GO:0005515 protein binding IPI 21130766
GO:0051015 NOT actin filament binding IRD --
genes like me logo Genes that share ontologies with CORO7: view

Phenotypes for CORO7 Gene

GenomeRNAi human phenotypes for CORO7:
genes like me logo Genes that share phenotypes with CORO7: view

miRNA for CORO7 Gene

miRTarBase miRNAs that target CORO7

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CORO7 Gene

Localization for CORO7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CORO7 Gene

Golgi apparatus membrane. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle. Cytoplasm, cytosol. Note=Predominantly cytosolic. Detected on vesicle-like cytoplasmic structures and on the cis-Golgi. Not associated with actin filaments.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CORO7 Gene COMPARTMENTS Subcellular localization image for CORO7 gene
Compartment Confidence
golgi apparatus 5
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CORO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus ISS --
GO:0005802 trans-Golgi network IDA 24768539
GO:0005829 cytosol IEA --
GO:0015629 NOT actin cytoskeleton IRD --
genes like me logo Genes that share ontologies with CORO7: view

Pathways for CORO7 Gene

genes like me logo Genes that share pathways with CORO7: view

Pathways by source for CORO7 Gene

2 Reactome pathways for CORO7 Gene

Gene Ontology (GO) - Biological Process for CORO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006895 Golgi to endosome transport IMP 24768539
GO:0015031 protein transport IEA --
GO:0030036 NOT actin cytoskeleton organization IRD --
GO:0030041 actin filament polymerization IMP 24768539
genes like me logo Genes that share ontologies with CORO7: view

Transcripts for CORO7 Gene

Unigene Clusters for CORO7 Gene

Coronin 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CORO7 Gene

No ASD Table

Relevant External Links for CORO7 Gene

GeneLoc Exon Structure for
CORO7
ECgene alternative splicing isoforms for
CORO7

Expression for CORO7 Gene

mRNA expression in normal human tissues for CORO7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CORO7 Gene

This gene is overexpressed in Testis (11.7) and Whole Blood (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CORO7 Gene

SOURCE GeneReport for Unigene cluster for CORO7 Gene Hs.437957

mRNA Expression by UniProt/SwissProt for CORO7 Gene

P57737-CORO7_HUMAN
Tissue specificity: Widely expressed. Expressed in the spleen, peripheral leukocytes, testes, brain, thymus and small intestine.
genes like me logo Genes that share expressions with CORO7: view

Orthologs for CORO7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CORO7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 99 (a)
OneToMany
CORO7 36
  • 97.06 (n)
  • 96.76 (a)
cow
(Bos Taurus)
Mammalia CORO7 36
  • 86.45 (n)
  • 87.21 (a)
CORO7 37
  • 87 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 87 (a)
OneToMany
CORO7 36
  • 86.04 (n)
  • 87.09 (a)
mouse
(Mus musculus)
Mammalia Coro7 36
  • 81.49 (n)
  • 84.82 (a)
Coro7 16
Coro7 37
  • 87 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 75 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Coro7 36
  • 80.69 (n)
  • 82.97 (a)
chicken
(Gallus gallus)
Aves CORO7 36
  • 68.92 (n)
  • 67.61 (a)
CORO7 37
  • 67 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 38 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.6618 36
tropical clawed frog
(Silurana tropicalis)
Amphibia coro7 36
  • 60.85 (n)
  • 57.28 (a)
Str.18329 36
zebrafish
(Danio rerio)
Actinopterygii coro7 36
  • 61.85 (n)
  • 57.28 (a)
coro7 37
  • 60 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000930 36
  • 43.84 (n)
  • 32.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta pod1 36
  • 51.29 (n)
  • 42.27 (a)
pod1 37
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pod-1 36
  • 45.96 (n)
  • 34.73 (a)
pod-1 37
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRN1 37
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 41 (a)
OneToMany
Species with no ortholog for CORO7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CORO7 Gene

ENSEMBL:
Gene Tree for CORO7 (if available)
TreeFam:
Gene Tree for CORO7 (if available)

Paralogs for CORO7 Gene

Paralogs for CORO7 Gene

genes like me logo Genes that share paralogs with CORO7: view

Variants for CORO7 Gene

Sequence variations from dbSNP and Humsavar for CORO7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
VAR_057585 -
VAR_057586 -
VAR_057587 -
VAR_057588 -

Structural Variations from Database of Genomic Variants (DGV) for CORO7 Gene

Variant ID Type Subtype PubMed ID
nsv527866 CNV Loss 19592680
nsv905223 CNV Loss 21882294
nsv905224 CNV Loss 21882294
dgv2585n71 CNV Loss 21882294
dgv2586n71 CNV Loss 21882294
nsv471075 CNV Loss 18288195
esv23732 CNV Gain 19812545
nsv905232 CNV Loss 21882294
esv2659570 CNV Deletion 23128226
nsv905233 CNV Loss 21882294
nsv520212 CNV Loss 19592680
nsv833132 CNV Loss 17160897

Relevant External Links for CORO7 Gene

HapMap Linkage Disequilibrium report
CORO7

Disorders for CORO7 Gene

Relevant External Links for CORO7

Genetic Association Database (GAD)
CORO7
Human Genome Epidemiology (HuGE) Navigator
CORO7
genes like me logo Genes that share disorders with CORO7: view

No data available for UniProtKB/Swiss-Prot for CORO7 Gene

Publications for CORO7 Gene

  1. Coronin 7, the mammalian POD-1 homologue, localizes to the Golgi apparatus. (PMID: 15327992) Rybakin V. … Hasse A. (FEBS Lett. 2004) 2 3 4
  2. Crn7 interacts with AP-1 and is required for the maintenance of Golgi morphology and protein export from the Golgi. (PMID: 16905771) Rybakin V. … Noegel A.A. (J. Biol. Chem. 2006) 3 4
  3. Molecular mechanism underlying the association of Coronin-7 with Golgi membranes. (PMID: 18581049) Rybakin V. … Clemen C.S. (Cell. Mol. Life Sci. 2008) 3 23
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob. (PMID: 21130766) Watanabe M. … Yamamoto T. (FEBS Lett. 2011) 3 4

Products for CORO7 Gene

Sources for CORO7 Gene

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