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CORO7 Gene

protein-coding   GIFtS: 53
GCID: GC16M004405

Coronin 7

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coronin 71 2     0610011B16Rik2
70 KDa WD Repeat Tumor Rejection Antigen Homolog2 3     coronin-72
CRN72 5     Crn73
POD12 5     

External Ids:    HGNC: 261611   Entrez Gene: 795852   Ensembl: ENSG000002622467   OMIM: 6116685   UniProtKB: P577373   

Export aliases for CORO7 gene to outside databases

Previous GC identifer: GC16M004344


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CORO7 Gene:
Coronins, such as CORO7, constitute an evolutionarily conserved family of WD-repeat actin-binding proteins. CORO7
plays a role in Golgi complex morphology and function (Rybakin et al., 2004, 2006 (PubMed 15327992) (PubMed
16905771)).(supplied by OMIM, Mar 2008)

GeneCards Summary for CORO7 Gene:
CORO7 (coronin 7) is a protein-coding gene. An important paralog of this gene is CORO1B.

UniProtKB/Swiss-Prot: CORO7_HUMAN, P57737
Function: May play a role in the maintenance of the Golgi apparatus morphology and in the protein export from the
Golgi




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010393.17  NT_187608.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the CORO7 gene promoter:
         AP-1   ATF-2   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCORO7 promoter sequence
   Search Chromatin IP Primers for CORO7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CORO7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

CORO7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CORO7 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M004405:  view genomic region     (about GC identifiers)

Start:
4,404,543 bp from pter      End:
4,475,706 bp from pter
Size:
71,164 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CORO7_HUMAN, P57737 (See protein sequence)
Recommended Name: Coronin-7  
Size: 925 amino acids; 100605 Da
Subunit: Interacted with clathrin adapter AP1 complex. This interaction takes place at Golgi membranes and not
AP1-positive endosomal membranes
Secondary accessions: B4DFD6 B4DL18 I3L416 Q17RK4
Alternative splicing: 4 isoforms:  P57737-1   P57737-2   P57737-3   P57737-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CORO7: NX_P57737

Explore proteomics data for CORO7 at MOPED

Post-translational modifications: 

  • The membrane-associated form is phosphorylated on tyrosine residues (By similarity)1
  • Ubiquitination2 at Lys157, Lys348, Lys472, Lys491, Lys508, Lys596, Lys680, Lys903
  • Modification sites at PhosphoSitePlus

  • See CORO7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001188401.1  NP_001188402.1  NP_078811.3  

    ENSEMBL proteins: 
     ENSP00000251166   ENSP00000458459   ENSP00000440460   ENSP00000461702   ENSP00000460177  
     ENSP00000460956   ENSP00000461187   ENSP00000459228   ENSP00000458828   ENSP00000459286  
     ENSP00000458411   ENSP00000460036   ENSP00000459085   ENSP00000461797   ENSP00000460901  
     ENSP00000460199   ENSP00000460910   ENSP00000461051   ENSP00000458935   ENSP00000459888  
     ENSP00000459401   ENSP00000446221   ENSP00000391530  

    CORO7 Human Recombinant Protein Products:

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    OriGene Purified Protein for CORO7
    OriGene Protein Over-expression Lysate for CORO7
    OriGene MassSpec for CORO7
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    GenScript Custom Purified and Recombinant Proteins Services for CORO7
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CORO7

     
    Search eBioscience for Proteins for CORO7 

     
    antibodies-online proteins for CORO7 (7 products) 

     
    antibodies-online peptides for CORO7

    CORO7 Antibody Products:

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    Abcam antibodies for CORO7
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    ThermoFisher Antibodies for CORO7
    antibodies-online antibodies for CORO7 (35 products) 

    CORO7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CORO7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CORO7
    Cloud-Clone Corp. CLIAs for CORO7
    Search eBioscience for ELISAs for CORO7 
    antibodies-online kits for CORO7 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing
    CORO: Coronins

    Selected InterPro protein domains (see all 8):
     IPR019775 WD40_repeat_CS
     IPR015049 DUF1900
     IPR027331 CORO7
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep

    Graphical View of Domain Structure for InterPro Entry P57737

    ProtoNet protein and cluster: P57737

    UniProtKB/Swiss-Prot: CORO7_HUMAN, P57737
    Similarity: Belongs to the WD repeat coronin family
    Similarity: Contains 8 WD repeats


    Find genes that share domains with CORO7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CORO7_HUMAN, P57737
    Function: May play a role in the maintenance of the Golgi apparatus morphology and in the protein export from the
    Golgi

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0051015NOT actin filament binding IRD--
         
    Find genes that share ontologies with CORO7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CORO7:
     Synthetic lethal with c-Myc af 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CORO7

    miRNA
    Products:
        
    miRTarBase miRNAs that target CORO7:
    hsa-mir-335-5p (MIRT018155), hsa-mir-92a-3p (MIRT049245)

    Block miRNA regulation of human, mouse, rat CORO7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CORO7 (see all 9):
    hsa-miR-31 hsa-miR-125a-5p hsa-miR-3146 hsa-miR-561 hsa-miR-570 hsa-miR-3943 hsa-miR-125b hsa-miR-302f
    SwitchGear 3'UTR luciferase reporter plasmidCORO7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CORO7
    Predesigned siRNA for gene silencing in human, mouse, rat CORO7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CORO7

    Clone
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    OriGene clones in human, mouse for CORO7 (see all 6)
    OriGene ORF clones in mouse, rat for CORO7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CORO7 (NM_024535)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CORO7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CORO7

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CORO7
    Browse ESI BIO Cell Lines and PureStem Progenitors for CORO7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORO7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CORO7_HUMAN, P57737: Cytoplasm, cytosol (By similarity). Golgi apparatus membrane. Cytoplasmic vesicle (By
    similarity). Note=Predominantly cytosolic. Detected on vesicle-like cytoplasmic structures and on the cis-Golgi.
    Not associated with actin filaments
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol3
    nucleus2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005794Golgi apparatus ISS--
    GO:0005829cytosol IEA--
    GO:0015629NOT actin cytoskeleton IRD--
    GO:0016021integral component of membrane ISS--

    Find genes that share ontologies with CORO7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CORO7 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    2Mitochondrial Protein Import
    Mitochondrial Protein Import



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CORO7
    Interactions:

        Search GeneGlobe Interaction Network for CORO7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for CORO7 (P577371, 2, 3 ENSP000002511664) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL1Q136162, 3, ENSP000003268044MINT-8076031 I2D: score=2 STRING: ENSP00000326804
    RBX1P628772, 3, ENSP000002162254MINT-8076057 I2D: score=2 STRING: ENSP00000216225
    TCEB2Q153702, 3, ENSP000002623064MINT-8076005 I2D: score=2 STRING: ENSP00000262306
    CDC34P494272, 3, ENSP000002155744MINT-8076046 I2D: score=2 STRING: ENSP00000215574
    TCEB1Q153692, 3, ENSP000002848114MINT-8076021 I2D: score=2 STRING: ENSP00000284811
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030036NOT actin cytoskeleton organization IRD--

    Find genes that share ontologies with CORO7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CORO7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CORO7 gene (3 alternative transcripts): 
    NM_001201472.1  NM_001201473.1  NM_024535.4  

    Unigene Cluster for CORO7:

    Coronin 7
    Hs.437957  [show with all ESTs]
    Unigene Representative Sequence: NM_024535
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 35):
    ENST00000251166(uc002cwh.4 uc010uxh.2 uc010uxi.2) ENST00000571227
    ENST00000537233 ENST00000574025 ENST00000576637 ENST00000570779 ENST00000575531
    ENST00000575714(uc002cwi.1) ENST00000574849 ENST00000572666 ENST00000572125
    ENST00000574311 ENST00000576437 ENST00000573773 ENST00000571756 ENST00000572549
    ENST00000572044 ENST00000573245
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CORO7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CORO7 (see all 9):
    hsa-miR-31 hsa-miR-125a-5p hsa-miR-3146 hsa-miR-561 hsa-miR-570 hsa-miR-3943 hsa-miR-125b hsa-miR-302f
    SwitchGear 3'UTR luciferase reporter plasmidCORO7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CORO7
    Predesigned siRNA for gene silencing in human, mouse, rat CORO7
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CORO7 (NM_024535)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CORO7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CORO7
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CORO7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CORO7
      QuantiTect SYBR Green Assays in human, mouse, rat CORO7
      QuantiFast Probe-based Assays in human, mouse, rat CORO7

    Additional mRNA sequence: 

    AK025674.1 AK094596.1 AK294045.1 AK296723.1 AK296807.1 AK309763.1 BC117289.1 BC117291.1 

    Selected DOTS entries (see all 28):

    DT.100842658  DT.100035681  DT.120686782  DT.100817257  DT.207654  DT.120686838  DT.120686756  DT.100035683 
    DT.100035684  DT.40107311  DT.449076  DT.101975547  DT.120686747  DT.120686858  DT.75177625  DT.95171805 
    DT.100704137  DT.102831733  DT.120686778  DT.120686811  DT.120686825  DT.120686843  DT.120686850  DT.91968358 

    Selected AceView cDNA sequences (see all 277):

    AI420340 BQ011933 BU622597 BM841885 AI922770 AW205935 AF349455 BQ711832 
    AI288705 AW071929 AI801913 BQ055732 AA513366 BE672892 AI807763 BC005024 
    AI800826 CB152664 BM710070 AY313265 AI057511 AK026514 AI312660 AK094596 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CORO7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCTGGGCA
    CORO7 Expression
    About this image


    CORO7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)
             Thymus
     
     Eye (Sensory Organs)
             Retina
    CORO7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CORO7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.437957
        Custom PCR Arrays for CORO7
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORO7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CORO7 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Coro71 , 5 coronin 71, 5 81.49(n)1
    84.82(a)1
      16 (2.45 cM)5
    788851  NM_030205.41  NP_084481.31 
     46261335 
    chicken
    (Gallus gallus)
    Aves CORO71 coronin 7 68.92(n)
    67.61(a)
      416670  NM_001006176.1  NP_001006176.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Coronin
    38(a)
    many ↔ many
    GL344890.1(1337-21507)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.66182 Xenopus laevis transcribed sequence with weak similarity more 74.22(n)    BJ074622.1 
    zebrafish
    (Danio rerio)
    Actinopterygii coro71 coronin 7 61.85(n)
    57.28(a)
      569563  NM_001030236.1  NP_001025407.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pod11 pod1 51.29(n)
    42.27(a)
      31620  NM_167092.2  NP_727126.1 
    worm
    (Caenorhabditis elegans)
    Secernentea pod-11 pod-1 45.96(n)
    34.73(a)
      176784  NM_067396.5  NP_499797.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CRN16
    Coronin, cortical actin cytoskeletal component tha...
    21(a)
    1 → many
    XII(990777-992732) YLR429W


    ENSEMBL Gene Tree for CORO7 (if available)
    TreeFam Gene Tree for CORO7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CORO7 gene
    CORO7-PAM161 2  CORO1B2  CORO1A2  CORO62  CORO1C2  CORO2B2  CORO2A2  
    11 SIMAP similar genes for CORO7 using alignment to 20 protein entries:     CORO7_HUMAN (see all proteins):
    CORO7-PAM16    WSB1    DKFZp762I166    CORO6    CORO1B    CORO1C
    PF20    CORO2A    CORO2B    CORO1A    POC1B

    Find genes that share paralogs with CORO7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    4 SNPs for CORO7    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs353575941,2,4
    ----see VAR_0575872 mis40--------
    rs99289671,2,4
    ----see VAR_0575882 mis40--------
    rs171370071,2,4
    ----see VAR_0575852 mis40--------
    rs37475791,2,4
    ----see VAR_0575862 mis40--------

    HapMap Linkage Disequilibrium report for CORO7 (4404543 - 4475706 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CORO7 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659570CNV Deletion23128226
    nsv471075CNV Loss18288195
    nsv833132CNV Loss17160897
    nsv527866CNV Loss19592680
    nsv905224CNV Loss21882294
    nsv905233CNV Loss21882294
    nsv905223CNV Loss21882294
    dgv2586n71CNV Loss21882294
    dgv2585n71CNV Loss21882294
    nsv905232CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CORO7
    DNA2.0 Custom Variant and Variant Library Synthesis for CORO7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 611668    OMIM disorders: --


    Find genes that share disorders with CORO7           About GenesLikeMe

    Genetic Association Database (GAD): CORO7
    Human Genome Epidemiology (HuGE) Navigator: CORO7 (1 document)

    Export disorders for CORO7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CORO7 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with CORO7)
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    1. Coronin 7, the mammalian POD-1 homologue, localizes to the Golgi apparatus. (PubMed id 15327992)1, 2, 3 Rybakin V.... Hasse A. (FEBS Lett. 2004)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Crn7 interacts with AP-1 and is required for the maintenance of Golgi morphology and protein export from the Golgi. (PubMed id 16905771)1, 2 Rybakin V....Noegel A.A. (J. Biol. Chem. 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Molecular mechanism underlying the association of Coronin-7 with Golgi membranes. (PubMed id 18581049)1, 9 Rybakin V....Clemen C.S. (Cell. Mol. Life Sci. 2008)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79585 HGNC: 26161 AceView: MagmasandCRN7 Ensembl:ENSG00000262246 euGenes: HUgn79585
    ECgene: CORO7 H-InvDB: CORO7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CORO7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CORO7 gene:
    Search GeneIP for patents involving CORO7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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