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Aliases for CORO7 Gene

Aliases for CORO7 Gene

  • Coronin 7 2 3 5
  • 70 KDa WD Repeat Tumor Rejection Antigen Homolog 3 4
  • CRN7 3 4
  • 0610011B16Rik 3
  • Coronin-7 3
  • POD1 3

External Ids for CORO7 Gene

Previous GeneCards Identifiers for CORO7 Gene

  • GC16M004344
  • GC16M004405

Summaries for CORO7 Gene

Entrez Gene Summary for CORO7 Gene

  • This gene encodes a member of the coronin protein family. However, unlike other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. The encoded protein has two tandem WD-40 domain repeats and localizes to the trans-Golgi network. The protein undergoes K33-linked polyubiquitination via an E3 ligase complex. It is thought to play an essential role in maintenance of Golgi apparatus morphology. Alternative splicing results in multiple transcripts variants; some of which form read-through transcripts with a neighboring gene. [provided by RefSeq, Dec 2016]

GeneCards Summary for CORO7 Gene

CORO7 (Coronin 7) is a Protein Coding gene. GO annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is CORO7-PAM16.

UniProtKB/Swiss-Prot for CORO7 Gene

  • F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via Lys-33-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORO7 Gene

Genomics for CORO7 Gene

Regulatory Elements for CORO7 Gene

Enhancers for CORO7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G004407 1.7 FANTOM5 ENCODE dbSUPER 11.9 +13.2 13169 10.2 HDGF PKNOX1 FOXA2 MLX AGO1 ZFP64 SIN3A ARID4B DMAP1 FEZF1 NMRAL1 CORO7 HMOX2 MGRN1 NUDT16L1 CORO7-PAM16 VASN
GH16G004485 1.6 Ensembl ENCODE dbSUPER 6.6 -62.7 -62687 6.2 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 NMRAL1 CDIP1 ZNF500 HMOX2 NUDT16L1 CLUAP1 GLIS2 CORO7 MGRN1
GH16G004458 1.5 Ensembl ENCODE dbSUPER 5.5 -33.6 -33600 1.7 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 ZNF121 SP5 MIER2 NMRAL1 VASN PAM16 MGRN1 CORO7 GC16P004458 GC16M004469
GH16G004313 1.7 Ensembl ENCODE dbSUPER 4.5 +106.1 106140 12.3 HDGF HNRNPUL1 PKNOX1 FOXA2 CREB3L1 ARNT AGO1 ZFP64 WRNIP1 ARID4B ZNF500 PAM16 ZNF174 CLUAP1 MTCO1P28 NMRAL1 LINC01569 HMOX2 CORO7 GLIS2
GH16G003960 1.8 FANTOM5 Ensembl ENCODE dbSUPER 3.6 +464.8 464779 1.8 TBP BMI1 RAD21 YY1 ZNF121 GLIS2 EGR1 ZNF366 ZSCAN5C SCRT2 SRL CREBBP ADCY9 PPL TNFRSF12A CORO7 GC16M003959 LOC102724927
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CORO7 on UCSC Golden Path with GeneCards custom track

Promoters for CORO7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082808 -95 1601 CREB3L1 MLX AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC

Genomic Location for CORO7 Gene

Chromosome:
16
Start:
4,354,542 bp from pter
End:
4,425,705 bp from pter
Size:
71,164 bases
Orientation:
Minus strand

Genomic View for CORO7 Gene

Genes around CORO7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORO7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORO7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO7 Gene

Proteins for CORO7 Gene

  • Protein details for CORO7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57737-CORO7_HUMAN
    Recommended name:
    Coronin-7
    Protein Accession:
    P57737
    Secondary Accessions:
    • B4DFD6
    • B4DL18
    • I3L416
    • Q17RK4

    Protein attributes for CORO7 Gene

    Size:
    925 amino acids
    Molecular mass:
    100605 Da
    Quaternary structure:
    • Interacts with clathrin adapter AP1 complex. This interaction takes place at Golgi membranes and not AP1-positive endosomal membranes. Interacts (when ubiquitinated at Lys-472) with EPS15.

    Alternative splice isoforms for CORO7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CORO7 Gene

Post-translational modifications for CORO7 Gene

  • The membrane-associated form is phosphorylated on tyrosine residues.
  • Ubiquitinated via Lys-33-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex: Lys-33-linked ubiquitination promotes interaction with EPS15 and facilitates actin polymerization at the trans-Golgi network, thereby facilitating post-Golgi trafficking. Deubiquitinated by ZRANB1/TRABID.
  • Ubiquitination at Lys157, Lys348, isoforms=2, 3, 4472, Lys491, isoforms=2, 3, 4508, isoforms=2, 3, 4596, isoforms=2, 3, 4680, and Lys903
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CORO7 Gene

Domains & Families for CORO7 Gene

Gene Families for CORO7 Gene

Suggested Antigen Peptide Sequences for CORO7 Gene

Graphical View of Domain Structure for InterPro Entry

P57737

UniProtKB/Swiss-Prot:

CORO7_HUMAN :
  • Belongs to the WD repeat coronin family.
Family:
  • Belongs to the WD repeat coronin family.
genes like me logo Genes that share domains with CORO7: view

Function for CORO7 Gene

Molecular function for CORO7 Gene

UniProtKB/Swiss-Prot Function:
F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via Lys-33-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.

Gene Ontology (GO) - Molecular Function for CORO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IDA,IEA 24768539
GO:0005515 protein binding IPI 21130766
genes like me logo Genes that share ontologies with CORO7: view

Phenotypes for CORO7 Gene

genes like me logo Genes that share phenotypes with CORO7: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CORO7 Gene

Localization for CORO7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CORO7 Gene

Golgi apparatus membrane. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle. Cytoplasm, cytosol. Note=Predominantly cytosolic. Detected on vesicle-like cytoplasmic structures and on the cis-Golgi. Not associated with actin filaments.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CORO7 gene
Compartment Confidence
golgi apparatus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CORO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA,ISS --
GO:0005802 trans-Golgi network IDA 24768539
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with CORO7: view

Pathways & Interactions for CORO7 Gene

SuperPathways for CORO7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CORO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006895 Golgi to endosome transport IMP 24768539
GO:0015031 protein transport IEA --
GO:0030041 actin filament polymerization IMP 24768539
genes like me logo Genes that share ontologies with CORO7: view

No data available for Pathways by source and SIGNOR curated interactions for CORO7 Gene

Transcripts for CORO7 Gene

Unigene Clusters for CORO7 Gene

Coronin 7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CORO7 Gene

No ASD Table

Relevant External Links for CORO7 Gene

GeneLoc Exon Structure for
CORO7
ECgene alternative splicing isoforms for
CORO7

Expression for CORO7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CORO7 Gene

mRNA differential expression in normal tissues according to GTEx for CORO7 Gene

This gene is overexpressed in Testis (x11.7) and Whole Blood (x7.4).

Protein differential expression in normal tissues from HIPED for CORO7 Gene

This gene is overexpressed in Lymph node (11.2), Tlymphocyte (8.6), NK cells (7.9), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CORO7 Gene



Protein tissue co-expression partners for CORO7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CORO7 Gene:

CORO7

SOURCE GeneReport for Unigene cluster for CORO7 Gene:

Hs.437957

mRNA Expression by UniProt/SwissProt for CORO7 Gene:

P57737-CORO7_HUMAN
Tissue specificity: Widely expressed. Expressed in the spleen, peripheral leukocytes, testes, brain, thymus and small intestine.

Evidence on tissue expression from TISSUES for CORO7 Gene

  • Nervous system(5)
  • Intestine(4.2)
  • Lung(2.9)
genes like me logo Genes that share expression patterns with CORO7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CORO7 Gene

Orthologs for CORO7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CORO7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 99 (a)
OneToMany
CORO7 34
  • 97.06 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 87 (a)
OneToMany
CORO7 34
  • 86.04 (n)
cow
(Bos Taurus)
Mammalia CORO7 34 35
  • 86.45 (n)
mouse
(Mus musculus)
Mammalia Coro7 34 35
  • 81.49 (n)
rat
(Rattus norvegicus)
Mammalia Coro7 34
  • 80.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 75 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 71 (a)
OneToMany
chicken
(Gallus gallus)
Aves CORO7 34 35
  • 68.92 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 38 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia coro7 34
  • 60.85 (n)
Str.18329 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6618 34
zebrafish
(Danio rerio)
Actinopterygii coro7 34 35
  • 61.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta pod1 34 35
  • 51.29 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000930 34
  • 43.84 (n)
worm
(Caenorhabditis elegans)
Secernentea pod-1 34 35
  • 45.96 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRN1 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToMany
Species where no ortholog for CORO7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CORO7 Gene

ENSEMBL:
Gene Tree for CORO7 (if available)
TreeFam:
Gene Tree for CORO7 (if available)

Paralogs for CORO7 Gene

Variants for CORO7 Gene

Sequence variations from dbSNP and Humsavar for CORO7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs864309494 Uncertain significance 4,355,236(-) TCGCA(C/T)ATGCC intron-variant
rs1000093995 -- 4,411,979(+) GGCCC(C/T)GAGCG intron-variant
rs1000120584 -- 4,380,768(+) GCATT(C/T)GGGGG intron-variant
rs1000142618 -- 4,402,768(+) TCCCC(A/G)GCTCA intron-variant
rs1000178796 -- 4,402,652(+) GGCAG(C/G)TGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CORO7 Gene

Variant ID Type Subtype PubMed ID
esv23732 CNV gain 19812545
esv2659570 CNV deletion 23128226
esv3584924 CNV gain 24956385
esv3637696 CNV loss 21293372
nsv1046986 CNV gain 25217958
nsv1160332 CNV duplication 26073780
nsv471075 CNV loss 18288195
nsv475644 CNV novel sequence insertion 20440878
nsv520212 CNV loss 19592680
nsv527866 CNV loss 19592680
nsv571274 CNV gain 21841781
nsv833132 CNV loss 17160897

Variation tolerance for CORO7 Gene

Residual Variation Intolerance Score: 96.6% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CORO7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CORO7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CORO7 Gene

Disorders for CORO7 Gene

Relevant External Links for CORO7

Genetic Association Database (GAD)
CORO7
Human Genome Epidemiology (HuGE) Navigator
CORO7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CORO7

No disorders were found for CORO7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CORO7 Gene

Publications for CORO7 Gene

  1. Coronin 7, the mammalian POD-1 homologue, localizes to the Golgi apparatus. (PMID: 15327992) Rybakin V. … Hasse A. (FEBS Lett. 2004) 2 3 4 64
  2. K33-linked polyubiquitination of coronin 7 by Cul3-KLHL20 ubiquitin E3 ligase regulates protein trafficking. (PMID: 24768539) Yuan W.C. … Chen R.H. (Mol. Cell 2014) 3 4 64
  3. Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob. (PMID: 21130766) Watanabe M. … Yamamoto T. (FEBS Lett. 2011) 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Molecular mechanism underlying the association of Coronin-7 with Golgi membranes. (PMID: 18581049) Rybakin V. … Clemen C.S. (Cell. Mol. Life Sci. 2008) 3 22 64

Products for CORO7 Gene

Sources for CORO7 Gene

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