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Aliases for CORO7 Gene

Aliases for CORO7 Gene

  • Coronin 7 2 3 5
  • 70 KDa WD Repeat Tumor Rejection Antigen Homolog 3 4
  • CRN7 3 4
  • 0610011B16Rik 3
  • Coronin-7 3
  • POD1 3

External Ids for CORO7 Gene

Previous GeneCards Identifiers for CORO7 Gene

  • GC16M004344
  • GC16M004405

Summaries for CORO7 Gene

Entrez Gene Summary for CORO7 Gene

  • Coronins, such as CORO7, constitute an evolutionarily conserved family of WD-repeat actin-binding proteins. CORO7 plays a role in Golgi complex morphology and function (Rybakin et al., 2004, 2006 [PubMed 15327992] [PubMed 16905771]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CORO7 Gene

CORO7 (Coronin 7) is a Protein Coding gene. GO annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is CORO7-PAM16.

UniProtKB/Swiss-Prot for CORO7 Gene

  • F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via Lys-33-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORO7 Gene

Genomics for CORO7 Gene

Regulatory Elements for CORO7 Gene

Enhancers for CORO7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CORO7 on UCSC Golden Path with GeneCards custom track

Promoters for CORO7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CORO7 on UCSC Golden Path with GeneCards custom track

Genomic Location for CORO7 Gene

Chromosome:
16
Start:
4,354,542 bp from pter
End:
4,425,705 bp from pter
Size:
71,164 bases
Orientation:
Minus strand

Genomic View for CORO7 Gene

Genes around CORO7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORO7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORO7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO7 Gene

Proteins for CORO7 Gene

  • Protein details for CORO7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57737-CORO7_HUMAN
    Recommended name:
    Coronin-7
    Protein Accession:
    P57737
    Secondary Accessions:
    • B4DFD6
    • B4DL18
    • I3L416
    • Q17RK4

    Protein attributes for CORO7 Gene

    Size:
    925 amino acids
    Molecular mass:
    100605 Da
    Quaternary structure:
    • Interacts with clathrin adapter AP1 complex. This interaction takes place at Golgi membranes and not AP1-positive endosomal membranes. Interacts (when ubiquitinated at Lys-472) with EPS15.

    Alternative splice isoforms for CORO7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CORO7 Gene

Post-translational modifications for CORO7 Gene

  • The membrane-associated form is phosphorylated on tyrosine residues.
  • Ubiquitinated via Lys-33-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex: Lys-33-linked ubiquitination promotes interaction with EPS15 and facilitates actin polymerization at the trans-Golgi network, thereby facilitating post-Golgi trafficking. Deubiquitinated by ZRANB1/TRABID.
  • Ubiquitination at Lys 157, Lys 348, Lys 472, Lys 491, Lys 508, Lys 596, Lys 680, and Lys 903
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CORO7 Gene

Domains & Families for CORO7 Gene

Gene Families for CORO7 Gene

Suggested Antigen Peptide Sequences for CORO7 Gene

Graphical View of Domain Structure for InterPro Entry

P57737

UniProtKB/Swiss-Prot:

CORO7_HUMAN :
  • Belongs to the WD repeat coronin family.
  • Contains 8 WD repeats.
Family:
  • Belongs to the WD repeat coronin family.
Similarity:
  • Contains 8 WD repeats.
genes like me logo Genes that share domains with CORO7: view

Function for CORO7 Gene

Molecular function for CORO7 Gene

UniProtKB/Swiss-Prot Function:
F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via Lys-33-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.

Gene Ontology (GO) - Molecular Function for CORO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IDA 24768539
GO:0005515 protein binding IPI 21130766
genes like me logo Genes that share ontologies with CORO7: view

Phenotypes for CORO7 Gene

genes like me logo Genes that share phenotypes with CORO7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CORO7 Gene

Localization for CORO7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CORO7 Gene

Golgi apparatus membrane. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle. Cytoplasm, cytosol. Note=Predominantly cytosolic. Detected on vesicle-like cytoplasmic structures and on the cis-Golgi. Not associated with actin filaments.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CORO7 Gene COMPARTMENTS Subcellular localization image for CORO7 gene
Compartment Confidence
golgi apparatus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CORO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus ISS --
GO:0005802 trans-Golgi network IDA 24768539
GO:0005829 cytosol IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CORO7: view

Pathways & Interactions for CORO7 Gene

SuperPathways for CORO7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CORO7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006895 Golgi to endosome transport IMP 24768539
GO:0015031 protein transport IEA --
GO:0030041 actin filament polymerization IMP 24768539
genes like me logo Genes that share ontologies with CORO7: view

No data available for Pathways by source and SIGNOR curated interactions for CORO7 Gene

Drugs & Compounds for CORO7 Gene

No Compound Related Data Available

Transcripts for CORO7 Gene

Unigene Clusters for CORO7 Gene

Coronin 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CORO7 Gene

No ASD Table

Relevant External Links for CORO7 Gene

GeneLoc Exon Structure for
CORO7
ECgene alternative splicing isoforms for
CORO7

Expression for CORO7 Gene

mRNA expression in normal human tissues for CORO7 Gene

mRNA differential expression in normal tissues according to GTEx for CORO7 Gene

This gene is overexpressed in Testis (x11.7) and Whole Blood (x7.4).

Protein differential expression in normal tissues from HIPED for CORO7 Gene

This gene is overexpressed in Lymph node (11.2), Tlymphocyte (8.6), NK cells (7.9), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CORO7 Gene



Protein tissue co-expression partners for CORO7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CORO7 Gene:

CORO7

SOURCE GeneReport for Unigene cluster for CORO7 Gene:

Hs.437957

mRNA Expression by UniProt/SwissProt for CORO7 Gene:

P57737-CORO7_HUMAN
Tissue specificity: Widely expressed. Expressed in the spleen, peripheral leukocytes, testes, brain, thymus and small intestine.
genes like me logo Genes that share expression patterns with CORO7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CORO7 Gene

Orthologs for CORO7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CORO7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CORO7 34
  • 86.45 (n)
  • 87.21 (a)
CORO7 35
  • 87 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CORO7 34
  • 86.04 (n)
  • 87.09 (a)
-- 35
  • 87 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Coro7 34
  • 81.49 (n)
  • 84.82 (a)
Coro7 35
  • 87 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CORO7 34
  • 97.06 (n)
  • 96.76 (a)
-- 35
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Coro7 34
  • 80.69 (n)
  • 82.97 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 75 (a)
OneToMany
chicken
(Gallus gallus)
Aves CORO7 34
  • 68.92 (n)
  • 67.61 (a)
CORO7 35
  • 67 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 38 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia coro7 34
  • 60.85 (n)
  • 57.28 (a)
Str.18329 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6618 34
zebrafish
(Danio rerio)
Actinopterygii coro7 34
  • 61.85 (n)
  • 57.28 (a)
coro7 35
  • 60 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000930 34
  • 43.84 (n)
  • 32.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta pod1 34
  • 51.29 (n)
  • 42.27 (a)
pod1 35
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pod-1 34
  • 45.96 (n)
  • 34.73 (a)
pod-1 35
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRN1 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToMany
Species where no ortholog for CORO7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CORO7 Gene

ENSEMBL:
Gene Tree for CORO7 (if available)
TreeFam:
Gene Tree for CORO7 (if available)

Paralogs for CORO7 Gene

Paralogs for CORO7 Gene

genes like me logo Genes that share paralogs with CORO7: view

Variants for CORO7 Gene

Sequence variations from dbSNP and Humsavar for CORO7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_057585 -
VAR_057586 -
VAR_057587 -
VAR_057588 -

Structural Variations from Database of Genomic Variants (DGV) for CORO7 Gene

Variant ID Type Subtype PubMed ID
esv23732 CNV gain 19812545
esv2659570 CNV deletion 23128226
esv3584924 CNV gain 24956385
esv3637696 CNV loss 21293372
nsv1046986 CNV gain 25217958
nsv1160332 CNV duplication 26073780
nsv471075 CNV loss 18288195
nsv475644 CNV novel sequence insertion 20440878
nsv520212 CNV loss 19592680
nsv527866 CNV loss 19592680
nsv571274 CNV gain 21841781
nsv833132 CNV loss 17160897

Variation tolerance for CORO7 Gene

Residual Variation Intolerance Score: 96.6% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CORO7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CORO7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CORO7 Gene

Disorders for CORO7 Gene

Relevant External Links for CORO7

Genetic Association Database (GAD)
CORO7
Human Genome Epidemiology (HuGE) Navigator
CORO7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CORO7

No disorders were found for CORO7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CORO7 Gene

Publications for CORO7 Gene

  1. Coronin 7, the mammalian POD-1 homologue, localizes to the Golgi apparatus. (PMID: 15327992) Rybakin V. … Hasse A. (FEBS Lett. 2004) 2 3 4 65
  2. K33-linked polyubiquitination of coronin 7 by Cul3-KLHL20 ubiquitin E3 ligase regulates protein trafficking. (PMID: 24768539) Yuan W.C. … Chen R.H. (Mol. Cell 2014) 3 4 65
  3. Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob. (PMID: 21130766) Watanabe M. … Yamamoto T. (FEBS Lett. 2011) 3 4 65
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  5. Molecular mechanism underlying the association of Coronin-7 with Golgi membranes. (PMID: 18581049) Rybakin V. … Clemen C.S. (Cell. Mol. Life Sci. 2008) 3 22 65

Products for CORO7 Gene

Sources for CORO7 Gene

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