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Aliases for CORO6 Gene

Aliases for CORO6 Gene

  • Coronin 6 2 3 5
  • Coronin-Like Protein E 3 4
  • Clipin-E 3 4
  • Coronin, Actin Binding Protein 6 3

External Ids for CORO6 Gene

Previous GeneCards Identifiers for CORO6 Gene

  • GC17M024965
  • GC17M027941
  • GC17M024151

Summaries for CORO6 Gene

GeneCards Summary for CORO6 Gene

CORO6 (Coronin 6) is a Protein Coding gene. GO annotations related to this gene include actin filament binding. An important paralog of this gene is CORO1A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORO6 Gene

Genomics for CORO6 Gene

Regulatory Elements for CORO6 Gene

Promoters for CORO6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CORO6 on UCSC Golden Path with GeneCards custom track

Genomic Location for CORO6 Gene

Chromosome:
17
Start:
29,614,756 bp from pter
End:
29,622,908 bp from pter
Size:
8,153 bases
Orientation:
Minus strand

Genomic View for CORO6 Gene

Genes around CORO6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORO6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORO6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO6 Gene

Proteins for CORO6 Gene

  • Protein details for CORO6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6QEF8-CORO6_HUMAN
    Recommended name:
    Coronin-6
    Protein Accession:
    Q6QEF8
    Secondary Accessions:
    • B3KU26
    • Q71MF3
    • Q8WYH7
    • Q96K02

    Protein attributes for CORO6 Gene

    Size:
    472 amino acids
    Molecular mass:
    52762 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG22467.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAG53288.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CORO6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CORO6 Gene

Proteomics data for CORO6 Gene at MOPED

Post-translational modifications for CORO6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CORO6 Gene

No data available for DME Specific Peptides for CORO6 Gene

Domains & Families for CORO6 Gene

Gene Families for CORO6 Gene

Protein Domains for CORO6 Gene

Suggested Antigen Peptide Sequences for CORO6 Gene

Graphical View of Domain Structure for InterPro Entry

Q6QEF8

UniProtKB/Swiss-Prot:

CORO6_HUMAN :
  • Contains 6 WD repeats.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with CORO6: view

Function for CORO6 Gene

Gene Ontology (GO) - Molecular Function for CORO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051015 actin filament binding IBA --
genes like me logo Genes that share ontologies with CORO6: view

Phenotypes for CORO6 Gene

MGI mutant phenotypes for CORO6:
inferred from 1 alleles
GenomeRNAi human phenotypes for CORO6:
genes like me logo Genes that share phenotypes with CORO6: view

Animal Models for CORO6 Gene

MGI Knock Outs for CORO6:

Animal Model Products

miRNA for CORO6 Gene

miRTarBase miRNAs that target CORO6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CORO6 Gene

Localization for CORO6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CORO6 Gene COMPARTMENTS Subcellular localization image for CORO6 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
golgi apparatus 2
mitochondrion 2
endoplasmic reticulum 1
nucleus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CORO6 Gene

Pathways & Interactions for CORO6 Gene

SuperPathways for CORO6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CORO6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CORO6 Gene

Drugs & Compounds for CORO6 Gene

No Compound Related Data Available

Transcripts for CORO6 Gene

Unigene Clusters for CORO6 Gene

Coronin 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CORO6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^
SP1: -
SP2: - - - - - -
SP3: - - -
SP4: - - - -
SP5: -
SP6:
SP7:
SP8: - - - - - - - - - - - - - - - -
SP9: - - -
SP10: - - - - - - -
SP11: -
SP12:

ExUns: 13a · 13b · 13c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for CORO6 Gene

GeneLoc Exon Structure for
CORO6
ECgene alternative splicing isoforms for
CORO6

Expression for CORO6 Gene

mRNA expression in normal human tissues for CORO6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CORO6 Gene

This gene is overexpressed in Muscle - Skeletal (x16.4).

Protein differential expression in normal tissues from HIPED for CORO6 Gene

This gene is overexpressed in Fetal heart (31.7) and Heart (20.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CORO6 Gene



SOURCE GeneReport for Unigene cluster for CORO6 Gene Hs.143046

genes like me logo Genes that share expression patterns with CORO6: view

Protein tissue co-expression partners for CORO6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CORO6 Gene

Orthologs for CORO6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CORO6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CORO6 35
  • 99.51 (n)
  • 99.58 (a)
CORO6 36
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CORO6 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CORO6 36
  • 86 (a)
OneToOne
CORO6 35
  • 92.71 (n)
  • 98.3 (a)
mouse
(Mus musculus)
Mammalia Coro6 16
Coro6 35
  • 86.77 (n)
  • 93.63 (a)
Coro6 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CORO6 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CORO6 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Coro6 35
  • 89.48 (n)
  • 96.4 (a)
chicken
(Gallus gallus)
Aves CORO6 35
  • 78.63 (n)
  • 80.25 (a)
CORO6 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CORO6 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia coro6 35
  • 71.7 (n)
  • 80.85 (a)
zebrafish
(Danio rerio)
Actinopterygii coro6 36
  • 71 (a)
OneToOne
coro6 35
  • 73.49 (n)
  • 78.35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.313 36
  • 43 (a)
OneToMany
Species with no ortholog for CORO6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CORO6 Gene

ENSEMBL:
Gene Tree for CORO6 (if available)
TreeFam:
Gene Tree for CORO6 (if available)

Paralogs for CORO6 Gene

Paralogs for CORO6 Gene

genes like me logo Genes that share paralogs with CORO6: view

Variants for CORO6 Gene

Sequence variations from dbSNP and Humsavar for CORO6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs871014 -- 29,618,321(-) GCCGG(A/G)TGCCC intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs2162660 -- 29,615,271(-) CTGAG(C/T)GGTAA nc-transcript-variant, utr-variant-3-prime
rs3809791 -- 29,618,029(-) CGCCG(G/T)GCGCG intron-variant, utr-variant-3-prime, utr-variant-5-prime
rs3809792 -- 29,617,127(-) AAGGC(C/T)AGGAA intron-variant, downstream-variant-500B
rs9890056 -- 29,622,750(+) GAGTG(A/C)GTAGG nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CORO6 Gene

Variant ID Type Subtype PubMed ID
nsv833409 CNV Gain 17160897
dgv3135n71 CNV Loss 21882294
nsv908038 CNV Loss 21882294
nsv833410 CNV Loss 17160897

Variation tolerance for CORO6 Gene

Residual Variation Intolerance Score: 59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CORO6 Gene

HapMap Linkage Disequilibrium report
CORO6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CORO6 Gene

Disorders for CORO6 Gene

Relevant External Links for CORO6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CORO6

No disorders were found for CORO6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CORO6 Gene

Publications for CORO6 Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4 67
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for CORO6 Gene

Sources for CORO6 Gene

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