Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CORO6 Gene

Aliases for CORO6 Gene

  • Coronin 6 2 3 5
  • Coronin-Like Protein E 3 4
  • Clipin-E 3 4
  • Coronin, Actin Binding Protein 6 3
  • Coronin-6 3

External Ids for CORO6 Gene

Previous GeneCards Identifiers for CORO6 Gene

  • GC17M024965
  • GC17M027941
  • GC17M024151

Summaries for CORO6 Gene

GeneCards Summary for CORO6 Gene

CORO6 (Coronin 6) is a Protein Coding gene. GO annotations related to this gene include actin filament binding. An important paralog of this gene is CORO1C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORO6 Gene

Genomics for CORO6 Gene

Regulatory Elements for CORO6 Gene

Enhancers for CORO6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F029638 1.7 FANTOM5 Ensembl ENCODE 51.8 -19.6 -19565 8.2 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZNF766 ZNF143 FOS REST CORO6 SMURF2P1 SH3GL1P2 ANKRD13B LRRC37BP1 ENSG00000264577 ENSG00000252657 NUFIP2 TAOK1 ENSG00000239129
GH17F029709 1.4 FANTOM5 ENCODE 48.6 -89.1 -89109 5.7 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS CORO6 SUZ12P1 LRRC37BP1 RNU6-920P SMURF2P1 RPL21P123 ENSG00000265625
GH17F029718 1.3 FANTOM5 ENCODE 48.6 -99.1 -99107 6.5 HDGF PKNOX1 ATF1 WRNIP1 GATA2 ELK1 ZNF143 JUNB TBX21 KAT8 CORO6 RNU6-920P NUFIP2 SSH2 TAOK1 RPL21P123 ENSG00000263657
GH17F029682 1.6 FANTOM5 Ensembl ENCODE 39.1 -60.0 -59952 2.8 CREB3L1 ARID4B SIN3A ZNF766 ZNF143 DEK ZNF263 NCOA1 MIER2 REST CORO6 RNU6-920P ANKRD13B SSH2 RPL21P123 ENSG00000265625
GH17F029691 1.5 FANTOM5 Ensembl ENCODE 38 -69.6 -69589 1.4 ATF1 ZNF121 ZNF366 FOS CEBPB JUNB ZEB2 REST SMARCA4 IKZF1 CORO6 RNU6-920P NSRP1 SSH2 NUFIP2 TAOK1 RPL21P123 ENSG00000265625
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CORO6 on UCSC Golden Path with GeneCards custom track

Promoters for CORO6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CORO6 Gene

29,614,756 bp from pter
29,622,908 bp from pter
8,153 bases
Minus strand

Genomic View for CORO6 Gene

Genes around CORO6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORO6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORO6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO6 Gene

Proteins for CORO6 Gene

  • Protein details for CORO6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B3KU26
    • Q71MF3
    • Q8WYH7
    • Q96K02

    Protein attributes for CORO6 Gene

    472 amino acids
    Molecular mass:
    52762 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG22467.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAG53288.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CORO6 Gene


neXtProt entry for CORO6 Gene

Post-translational modifications for CORO6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CORO6 Gene

Domains & Families for CORO6 Gene

Gene Families for CORO6 Gene

Suggested Antigen Peptide Sequences for CORO6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 WD repeats.
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with CORO6: view

Function for CORO6 Gene

Gene Ontology (GO) - Molecular Function for CORO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0051015 actin filament binding IBA --
genes like me logo Genes that share ontologies with CORO6: view

Phenotypes for CORO6 Gene

MGI mutant phenotypes for CORO6:
inferred from 1 alleles
GenomeRNAi human phenotypes for CORO6:
genes like me logo Genes that share phenotypes with CORO6: view

Animal Models for CORO6 Gene

MGI Knock Outs for CORO6:

Animal Model Products

miRNA for CORO6 Gene

miRTarBase miRNAs that target CORO6

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CORO6 Gene

Localization for CORO6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CORO6 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
mitochondrion 2
golgi apparatus 2
plasma membrane 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CORO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015629 actin cytoskeleton IBA --
genes like me logo Genes that share ontologies with CORO6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CORO6 Gene

Pathways & Interactions for CORO6 Gene

SuperPathways for CORO6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CORO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030036 actin cytoskeleton organization IBA --
genes like me logo Genes that share ontologies with CORO6: view

No data available for Pathways by source and SIGNOR curated interactions for CORO6 Gene

Transcripts for CORO6 Gene

Unigene Clusters for CORO6 Gene

Coronin 6:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CORO6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^
SP1: -
SP2: - - - - - -
SP3: - - -
SP4: - - - -
SP5: -
SP8: - - - - - - - - - - - - - - - -
SP9: - - -
SP10: - - - - - - -
SP11: -

ExUns: 13a · 13b · 13c

Relevant External Links for CORO6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CORO6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CORO6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CORO6 Gene

This gene is overexpressed in Muscle - Skeletal (x16.4).

Protein differential expression in normal tissues from HIPED for CORO6 Gene

This gene is overexpressed in Fetal heart (31.7) and Heart (20.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CORO6 Gene

Protein tissue co-expression partners for CORO6 Gene

NURSA nuclear receptor signaling pathways regulating expression of CORO6 Gene:


SOURCE GeneReport for Unigene cluster for CORO6 Gene:

genes like me logo Genes that share expression patterns with CORO6: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CORO6 Gene

Orthologs for CORO6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CORO6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CORO6 34 35
  • 99.51 (n)
(Bos Taurus)
Mammalia CORO6 35
  • 98 (a)
(Monodelphis domestica)
Mammalia CORO6 35
  • 93 (a)
(Canis familiaris)
Mammalia CORO6 34 35
  • 92.71 (n)
(Rattus norvegicus)
Mammalia Coro6 34
  • 89.48 (n)
(Mus musculus)
Mammalia Coro6 34 16 35
  • 86.77 (n)
(Ornithorhynchus anatinus)
Mammalia CORO6 35
  • 73 (a)
(Gallus gallus)
Aves CORO6 34 35
  • 78.63 (n)
(Anolis carolinensis)
Reptilia CORO6 35
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia coro6 34
  • 71.7 (n)
(Danio rerio)
Actinopterygii coro6 34 35
  • 73.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.313 35
  • 43 (a)
Species where no ortholog for CORO6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CORO6 Gene

Gene Tree for CORO6 (if available)
Gene Tree for CORO6 (if available)

Paralogs for CORO6 Gene

Paralogs for CORO6 Gene

genes like me logo Genes that share paralogs with CORO6: view

Variants for CORO6 Gene

Sequence variations from dbSNP and Humsavar for CORO6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs772136445 Uncertain significance 29,615,803(+) CTGCA(A/C)CCGCT nc-transcript-variant, downstream-variant-500B, reference, missense
rs1064133 -- 29,614,729(-) CCTCA(A/G)AATCA nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs111487344 -- 29,614,765(+) GAGGC(G/T)TTTGC intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs111572312 -- 29,616,338(+) GAACC(A/G/T)ATAAG splice-acceptor-variant
rs112030766 -- 29,621,222(+) CCCTC(A/G)CCTTG splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for CORO6 Gene

Variant ID Type Subtype PubMed ID
nsv953874 CNV deletion 24416366
nsv833410 CNV loss 17160897
nsv833409 CNV gain 17160897

Variation tolerance for CORO6 Gene

Residual Variation Intolerance Score: 59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CORO6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CORO6 Gene

Disorders for CORO6 Gene

Relevant External Links for CORO6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CORO6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CORO6 Gene

Publications for CORO6 Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64

Products for CORO6 Gene

Sources for CORO6 Gene

Loading form....