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Aliases for CORO2B Gene

Aliases for CORO2B Gene

  • Coronin 2B 2 3 5
  • Coronin-Like Protein C 3 4
  • Clipin C 2 3
  • Coronin, Actin-Binding Protein, 2B 2
  • Coronin, Actin Binding Protein, 2B 3
  • Coronin, Actin-Binding, 2B 2
  • Protein FC96 4
  • Coronin-2B 3
  • Clipin-C 4
  • KIAA0925 4
  • CLIPINC 3

External Ids for CORO2B Gene

Previous GeneCards Identifiers for CORO2B Gene

  • GC15P064711
  • GC15P061970
  • GC15P066450
  • GC15P066587
  • GC15P066658
  • GC15P068871
  • GC15P045742

Summaries for CORO2B Gene

GeneCards Summary for CORO2B Gene

CORO2B (Coronin 2B) is a Protein Coding gene. GO annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is CORO2A.

UniProtKB/Swiss-Prot for CORO2B Gene

  • May play a role in the reorganization of neuronal actin structure.

Additional gene information for CORO2B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORO2B Gene

Genomics for CORO2B Gene

Regulatory Elements for CORO2B Gene

Enhancers for CORO2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H068275 1.7 Ensembl ENCODE dbSUPER 13.3 -279.9 -279865 8.8 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC ZC3H11A PPARGC1A SKOR1 ENSG00000260657 IQCH-AS1 PIAS1 ENSG00000259410 ENSG00000259265 CORO2B MAP2K5 NOX5 GC15M068298
GH15H069451 1.7 Ensembl ENCODE dbSUPER 13.3 +893.9 893907 4.1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ENSG00000259265 CORO2B TLE3 NOX5 RPLP1 GC15M069460 ENSG00000207119
GH15H068637 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +80.2 80228 4.9 NRF1 REST ZIC2 NR2F2 ZFHX2 ZNF776 PRDM6 POLR2A ZNF169 SCRT2 CORO2B GC15M068584 GC15M068576
GH15H068673 1.4 Ensembl ENCODE dbSUPER 12.4 +115.6 115574 2 PKNOX1 RB1 SIN3A KLF17 ZNF2 RAD21 RFX5 ZNF121 ZNF143 RCOR1 CORO2B GC15M068584 GC15P068946
GH15H068535 1.2 Ensembl ENCODE dbSUPER 13.2 -22.4 -22399 2.5 ZNF175 CEBPG ZBTB40 SCRT2 ZNF143 FOS TRIM24 ZNF584 THAP11 ZNF197 CORO2B GC15M068493
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CORO2B on UCSC Golden Path with GeneCards custom track

Genomic Locations for CORO2B Gene

Genomic Locations for CORO2B Gene
chr15:68,559,275-68,727,806
(GRCh38/hg38)
Size:
168,532 bases
Orientation:
Plus strand
chr15:68,871,308-69,020,145
(GRCh37/hg19)

Genomic View for CORO2B Gene

Genes around CORO2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORO2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORO2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO2B Gene

Proteins for CORO2B Gene

  • Protein details for CORO2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQ03-COR2B_HUMAN
    Recommended name:
    Coronin-2B
    Protein Accession:
    Q9UQ03
    Secondary Accessions:
    • A8K0W3
    • O94767
    • Q8TAN1

    Protein attributes for CORO2B Gene

    Size:
    480 amino acids
    Molecular mass:
    54953 Da
    Quaternary structure:
    • Binds to F-actin and to vinculin.
    SequenceCaution:
    • Sequence=AAH26335.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA36341.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CORO2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CORO2B Gene

Post-translational modifications for CORO2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CORO2B Gene

No data available for DME Specific Peptides for CORO2B Gene

Domains & Families for CORO2B Gene

Gene Families for CORO2B Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CORO2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UQ03

UniProtKB/Swiss-Prot:

COR2B_HUMAN :
  • Belongs to the WD repeat coronin family.
Family:
  • Belongs to the WD repeat coronin family.
genes like me logo Genes that share domains with CORO2B: view

Function for CORO2B Gene

Molecular function for CORO2B Gene

GENATLAS Biochemistry:
coronin 2B,homolog to Dictyostelium discoideum coronin,a soluble actin-binding protein,predominantly expressed in brain,accumulating at focal adhesions as well as at neurite tips and stress fibers where it associates with vinculin,suggesting that coronin 2B plays a specific role in cross-binding the actin cytoskeleton and plasma membrane
UniProtKB/Swiss-Prot Function:
May play a role in the reorganization of neuronal actin structure.

Phenotypes From GWAS Catalog for CORO2B Gene

Gene Ontology (GO) - Molecular Function for CORO2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding NAS 10224093
GO:0005515 protein binding IPI 25416956
GO:0051015 actin filament binding IBA --
genes like me logo Genes that share ontologies with CORO2B: view
genes like me logo Genes that share phenotypes with CORO2B: view

miRNA for CORO2B Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CORO2B Gene

Localization for CORO2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CORO2B Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CORO2B gene
Compartment Confidence
cytoskeleton 3
cytosol 3
plasma membrane 2
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CORO2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0015629 actin cytoskeleton NAS 10224093
GO:0016020 membrane IEA,NAS 10224093
genes like me logo Genes that share ontologies with CORO2B: view

Pathways & Interactions for CORO2B Gene

SuperPathways for CORO2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for CORO2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030036 actin cytoskeleton organization NAS,IBA 10224093
genes like me logo Genes that share ontologies with CORO2B: view

No data available for Pathways by source and SIGNOR curated interactions for CORO2B Gene

Drugs & Compounds for CORO2B Gene

No Compound Related Data Available

Transcripts for CORO2B Gene

Unigene Clusters for CORO2B Gene

Coronin, actin binding protein, 2B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CORO2B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^
SP1: - - - - - - - -
SP2: -
SP3: - - - -
SP4: - -
SP5: - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP8:
SP9: - -
SP10:

ExUns: 18a · 18b · 18c · 18d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CORO2B Gene

GeneLoc Exon Structure for
CORO2B
ECgene alternative splicing isoforms for
CORO2B

Expression for CORO2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CORO2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CORO2B Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.0).

Protein differential expression in normal tissues from HIPED for CORO2B Gene

This gene is overexpressed in Frontal cortex (21.5), Retina (13.7), Spinal cord (9.7), and Fetal Brain (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CORO2B Gene



Protein tissue co-expression partners for CORO2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CORO2B Gene:

CORO2B

SOURCE GeneReport for Unigene cluster for CORO2B Gene:

Hs.551213

mRNA Expression by UniProt/SwissProt for CORO2B Gene:

Q9UQ03-COR2B_HUMAN
Tissue specificity: Expressed predominantly in brain.

Evidence on tissue expression from TISSUES for CORO2B Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with CORO2B: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CORO2B Gene

Orthologs for CORO2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CORO2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CORO2B 33 34
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia CORO2B 33 34
  • 93.75 (n)
cow
(Bos Taurus)
Mammalia CORO2B 33 34
  • 92.97 (n)
mouse
(Mus musculus)
Mammalia Coro2b 33 16 34
  • 91.46 (n)
rat
(Rattus norvegicus)
Mammalia Coro2b 33
  • 91.18 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CORO2B 34
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CORO2B 34
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves CORO2B 33 34
  • 83.86 (n)
lizard
(Anolis carolinensis)
Reptilia CORO2B 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia coro2b 33
  • 75.6 (n)
zebrafish
(Danio rerio)
Actinopterygii coro2ba 33 34
  • 77.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta coro 34
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cor-1 35 34
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRN1 34
  • 27 (a)
OneToMany
Species where no ortholog for CORO2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CORO2B Gene

ENSEMBL:
Gene Tree for CORO2B (if available)
TreeFam:
Gene Tree for CORO2B (if available)

Paralogs for CORO2B Gene

Paralogs for CORO2B Gene

(7) SIMAP similar genes for CORO2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CORO2B: view

Variants for CORO2B Gene

Sequence variations from dbSNP and Humsavar for CORO2B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_035878 A colorectal cancer sample
rs1000010858 -- 68,598,844(+) GAAGA(A/G)TGACT intron-variant
rs1000025885 -- 68,706,707(+) TGGTA(-/T)TTTTT intron-variant
rs1000076671 -- 68,595,192(+) TGGGG(G/T)CAGGC intron-variant
rs1000077004 -- 68,579,669(+) TGTGG(C/G)GATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CORO2B Gene

Variant ID Type Subtype PubMed ID
nsv833046 CNV loss 17160897
nsv569807 CNV loss 21841781
nsv515835 CNV loss 19592680
nsv457189 CNV loss 19166990
nsv1108965 CNV deletion 24896259
nsv1070711 CNV deletion 25765185
esv3636808 CNV loss 21293372
esv3636807 CNV loss 21293372
esv3552616 CNV deletion 23714750
esv33989 CNV gain 17666407
esv3351322 CNV insertion 20981092
esv3327513 CNV insertion 20981092
esv3306659 CNV mobile element insertion 20981092
esv2749818 CNV deletion 23290073
esv2749817 CNV deletion 23290073
esv2672538 CNV deletion 23128226
esv2487574 CNV deletion 19546169

Variation tolerance for CORO2B Gene

Residual Variation Intolerance Score: 13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CORO2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CORO2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CORO2B Gene

Disorders for CORO2B Gene

Relevant External Links for CORO2B

Genetic Association Database (GAD)
CORO2B
Human Genome Epidemiology (HuGE) Navigator
CORO2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CORO2B

No disorders were found for CORO2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CORO2B Gene

Publications for CORO2B Gene

  1. A neurally enriched coronin-like protein, ClipinC, is a novel candidate for an actin cytoskeleton-cortical membrane-linking protein. (PMID: 10224093) Nakamura T … Mori N (The Journal of biological chemistry 1999) 2 3 4 22 60
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need AC … Goldstein DB (Human molecular genetics 2009) 3 45 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for CORO2B Gene

Sources for CORO2B Gene

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