Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CORO2B Gene

protein-coding   GIFtS: 57
GCID: GC15P068871

Coronin, Actin Binding Protein, 2B

(Previous names: coronin, actin-binding protein, 2B)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coronin, Actin Binding Protein, 2B1 2     coronin1
Clipin C1 2     Coronin, Actin-Binding Protein, 2B1
Coronin-Like Protein C2 3     coronin-2B2
CLIPINC2 5     Clipin-C3
2B1     KIAA09253
actin-binding1     Protein FC963

External Ids:    HGNC: 22561   Entrez Gene: 103912   Ensembl: ENSG000001036477   OMIM: 6050025   UniProtKB: Q9UQ033   

Export aliases for CORO2B gene to outside databases

Previous GC identifers: GC15P064711 GC15P061970 GC15P066450 GC15P066587 GC15P066658 GC15P045742


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CORO2B Gene: 
CORO2B (coronin, actin binding protein, 2B) is a protein-coding gene. Diseases associated with CORO2B include neuronitis. GO annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is CORO1B.

UniProtKB/Swiss-Prot: COR2B_HUMAN, Q9UQ03
Function: May play a role in the reorganization of neuronal actin structure




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CORO2B gene promoter:
         ER-alpha   USF1   USF2   USF-1:USF-2   CREB   USF-1   deltaCREB   TGIF   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCORO2B promoter sequence
   Search SABiosciences Chromatin IP Primers for CORO2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CORO2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23   Ensembl cytogenetic band:  15q23   HGNC cytogenetic band: 15q22.31

CORO2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CORO2B gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P068871:  view genomic region     (about GC identifiers)

Start:
68,871,308 bp from pter      End:
69,020,145 bp from pter
Size:
148,838 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: COR2B_HUMAN, Q9UQ03 (See protein sequence)
Recommended Name: Coronin-2B  
Size: 480 amino acids; 54953 Da
Subunit: Binds to F-actin and to vinculin
Subcellular location: Cytoplasm, cytoskeleton (Probable)
Sequence caution: Sequence=AAH26335.1; Type=Erroneous initiation; Sequence=BAA36341.1; Type=Erroneous initiation;
Secondary accessions: A8K0W3 O94767 Q8TAN1
Alternative splicing: 2 isoforms:  Q9UQ03-1   Q9UQ03-2   

Explore the universe of human proteins at neXtProt for CORO2B: NX_Q9UQ03

Explore proteomics data for CORO2B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UQ03

  • CORO2B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CORO2B Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001177385.1  NP_001177386.1  NP_006082.3  

    ENSEMBL proteins: 
     ENSP00000261861   ENSP00000454783   ENSP00000446250   ENSP00000443819  

    Human Recombinant Protein Products for CORO2B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CORO2B
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CORO2B
    GenScript Custom Purified and Recombinant Proteins Services for CORO2B
    Novus Biologicals CORO2B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CORO2B 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0015629actin cytoskeleton NAS10224093
    GO:0016020membrane NAS10224093

    CORO2B for ontologies           About GeneDecksing



    CORO2B Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CORO2B
    GenScript Custom Superior Antibodies Services for CORO2B
    Novus Biologicals CORO2B Antibodies
    Abcam antibodies for CORO2B
    Cloud-Clone Corp. Antibodies for CORO2B 
    ThermoFisher Antibody for CORO2B
    LSBio Antibodies in human, mouse, rat for CORO2B 

    Assay Products for CORO2B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CORO2B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CORO2B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CORO2B 
    Cloud-Clone Corp. CLIAs for CORO2B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing
    CORO: Coronins

    5/8 InterPro protein domains (see all 8):
     IPR019775 WD40_repeat_CS
     IPR027339 CORO2B
     IPR015049 DUF1900
     IPR001680 WD40_repeat
     IPR015505 Coronin

    Graphical View of Domain Structure for InterPro Entry Q9UQ03

    ProtoNet protein and cluster: Q9UQ03

    UniProtKB/Swiss-Prot: COR2B_HUMAN, Q9UQ03
    Similarity: Belongs to the WD repeat coronin family
    Similarity: Contains 5 WD repeats


    CORO2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COR2B_HUMAN, Q9UQ03
    Function: May play a role in the reorganization of neuronal actin structure

         Genatlas biochemistry entry for CORO2B:
    coronin 2B,homolog to Dictyostelium discoideum coronin,a soluble actin-binding protein,predominantly expressed in
    brain,accumulating at focal adhesions as well as at neurite tips and stress fibers where it associates with
    vinculin,suggesting that coronin 2B plays a specific role in cross-binding the actin cytoskeleton and plasma
    membrane

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding NAS10224093
    GO:0005515protein binding ----
    GO:0051015actin filament binding IBA--
         
    CORO2B for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CORO2B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CORO2B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CORO2B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CORO2B 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CORO2B:
    hsa-mir-185 (MIRT004703)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CORO2B
    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate CORO2B (see all 53):
    hsa-miR-302d hsa-miR-520e hsa-miR-3938 hsa-miR-330-5p hsa-miR-106a hsa-miR-650 hsa-miR-570 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidCORO2B 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CORO2B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CORO2B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CORO2B
    Sirion Biotech Customized adenovirus for overexpression of CORO2B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CORO2B (see all 10)
    OriGene ORF clones in mouse, rat for CORO2B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CORO2B (NM_006091)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CORO2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CORO2B
    Sirion Biotech Customized lentivirus for stable overexpression of CORO2B 
                         Customized lentivirus expression plasmids for stable overexpression of CORO2B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CORO2B
    Search LifeMap BioReagents cell lines for CORO2B
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORO2B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CORO2B

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for CORO2B (Q9UQ032, 3 ENSP000002618614) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSC22D1Q157142, 3, ENSP000003974354MINT-64580 I2D: score=5 STRING: ENSP00000397435
    VCLP182063, ENSP000002119984I2D: score=3 STRING: ENSP00000211998
    ACTA1P681333, ENSP000003556454I2D: score=2 STRING: ENSP00000355645
    OPCMLQ149823I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030036actin cytoskeleton organization NAS10224093

    CORO2B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CORO2B (COR2B)

    Search CenterWatch for drugs/clinical trials and news about CORO2B / COR2B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CORO2B gene (3 alternative transcripts): 
    NM_001190456.1  NM_001190457.1  NM_006091.4  

    Unigene Cluster for CORO2B:

    Coronin, actin binding protein, 2B
    Hs.551213  [show with all ESTs]
    Unigene Representative Sequence: NM_001190457
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261861(uc002arj.4 uc002ark.3) ENST00000566799 ENST00000540068(uc021spj.1)
    ENST00000543950(uc010bic.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CORO2B
    8/53 QIAGEN miScript miRNA Assays for microRNAs that regulate CORO2B (see all 53):
    hsa-miR-302d hsa-miR-520e hsa-miR-3938 hsa-miR-330-5p hsa-miR-106a hsa-miR-650 hsa-miR-570 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidCORO2B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CORO2B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CORO2B
    Clone
    Products:
         
    OriGene clones in human, mouse for CORO2B (see all 10)
    OriGene ORF clones in mouse, rat for CORO2B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CORO2B (NM_006091)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CORO2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CORO2B
    Sirion Biotech Customized lentivirus for stable overexpression of CORO2B 
                         Customized lentivirus expression plasmids for stable overexpression of CORO2B 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CORO2B
    OriGene qSTAR qPCR primer pairs in human, mouse for CORO2B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CORO2B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CORO2B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CORO2B

    Additional mRNA sequence: 

    AB010098.1 AB023142.1 AK289678.1 BC026335.1 BC128424.1 

    10 DOTS entries:

    DT.111233  DT.101958753  DT.121014804  DT.100679598  DT.121014817  DT.100757708  DT.121014807  DT.121014831 
    DT.91796748  DT.92421755 

    24/98 AceView cDNA sequences (see all 98):

    BQ185964 AI480196 AL533625 AL079954 Z41417 BM465611 BF939649 AI634066 
    AB010098 W20512 AB023142 BG702128 AI077487 BM695896 AI986153 BX090424 
    CR609225 CA396906 BQ440134 BP348937 AW235874 AI201815 AI568640 BM666973 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CORO2B (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^
    SP1:              -     -     -     -     -     -                                                                 -                             -               
    SP2:                                                                                                                                            -               
    SP3:                          -     -     -     -                                                                                                               
    SP4:                                      -     -                                                                                                               
    SP5:                    -     -     -     -     -                                                                                                               

    ExUns: 18a · 18b · 18c · 18d
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for CORO2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CORO2B expression in normal human tissues (normalized intensities)      CORO2B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGCCCTAC
    CORO2B Expression
    About this image


    CORO2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Intervertebral Disc Annulus Fibrosus Cells Thoracic Intervertebral Disc
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
             Cingulate Cortex   
     
     Eye (Sensory Organs)
             Retina
     
     Uncategorized (Uncategorized)
             PureStem Progenitor ES-198

    See CORO2B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CORO2B

    SOURCE GeneReport for Unigene cluster: Hs.551213

    UniProtKB/Swiss-Prot: COR2B_HUMAN, Q9UQ03
    Tissue specificity: Expressed predominantly in brain

        SABiosciences Custom PCR Arrays for CORO2B
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CORO2B
    OriGene qSTAR qPCR primer pairs in human, mouse for CORO2B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CORO2B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CORO2B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CORO2B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORO2B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CORO2B gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Coro2b1 , 5 coronin, actin binding protein, 2B1, 5 91.46(n)1
    98.12(a)1
      9 (33.71 cM)5
    2354311  NM_175484.31  NP_780693.21 
     624194925 
    chicken
    (Gallus gallus)
    Aves CORO2B1 coronin, actin binding protein, 2B 84.11(n)
    94.51(a)
      415561  XM_003641863.1  XP_003641911.1 
    lizard
    (Anolis carolinensis)
    Reptilia CORO2B6
    coronin, actin binding protein, 2B
    92(a)
    1 ↔ 1
    GL343671.1(186144-247999)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF290495.12   -- 75.94(n)    CF290495.1 
    zebrafish
    (Danio rerio)
    Actinopterygii coro2ba1 coronin, actin binding protein, 2Ba 76.77(n)
    87.08(a)
      560235  XM_683629.2  XP_688721.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CRN16
    Coronin, cortical actin cytoskeletal component tha...
    26(a)
    1 → many
    XII(990777-992732)


    ENSEMBL Gene Tree for CORO2B (if available)
    TreeFam Gene Tree for CORO2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CORO2B gene
    CORO1B2  CORO7-PAM162  CORO1A2  CORO62  CORO72  CORO1C2  CORO2A2  
    7 SIMAP similar genes for CORO2B using alignment to 1 protein entry:     COR2B_HUMAN:
    CORO2A    CORO1C    CORO1B    DKFZp762I166    CORO6    CORO1A
    CORO7

    CORO2B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3104 SNPs in CORO2B are shown (see all 3104)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358784
    A colorectal cancer sample4--see VAR_0358782 P L mis40--------
    rs105798451,2
    C--49018604(+) AAAAA-/A/AA  
            
    GGACA
    3 -- int1 trp32NA 4
    rs1449419151,2
    --68869388(+) CATTCC/TTGGCA 1 -- us2k10--------
    rs1175042531,2
    C,F--68869444(+) GAGACG/TCCTGA 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs6151881,2
    C,F,O,A,H--68869582(+) CCCTGG/CAGTTC 1 -- us2k1103Minor allele frequency- C:0.04NS EA PA EU CA WA NA CSA 5144
    rs1849802121,2
    --68869643(+) GTCCTC/TGCTCT 1 -- us2k10--------
    rs1898620441,2
    --68869953(+) TCCTCA/GGGGGG 1 -- us2k10--------
    rs1820038571,2
    --68869983(+) TGAATA/CCAGGA 1 -- us2k10--------
    rs1853710131,2
    --68869990(+) AGGAGA/GCGGAG 1 -- us2k10--------
    rs113899251,2
    C--68870063(+) AAAAA-/AAAAAA 1 -- us2k1 trp30--------

    HapMap Linkage Disequilibrium report for CORO2B (68871308 - 69020145 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CORO2B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672538CNV Deletion23128226
    esv2749817CNV Deletion23290073
    esv2487574CNV Deletion19546169
    esv2749818CNV Deletion23290073
    esv272597CNV Insertion20981092
    esv270935CNV Insertion20981092
    nsv457189CNV Loss19166990
    nsv515835CNV Loss19592680
    nsv833046CNV Loss17160897
    esv33989CNV Gain17666407

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CORO2B
    DNA2.0 Custom Variant and Variant Library Synthesis for CORO2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605002    OMIM disorders: --

    2 diseases for CORO2B:    About MalaCards
    neuronitis    


    CORO2B for disorders           About GeneDecksing

    Genetic Association Database (GAD): CORO2B
    Human Genome Epidemiology (HuGE) Navigator: CORO2B (1 document)

    Export disorders for CORO2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CORO2B gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with CORO2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A neurally enriched coronin-like protein, ClipinC, is a novel candidate for an actin cytoskeleton-cortical membrane-linking protein. (PubMed id 10224093)1, 2, 3, 9 Nakamura T....Mori N. (1999)
    2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (1999)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. A genome-wide study of common SNPs and CNVs in cognit ive performance in the CANTAB. (PubMed id 19734545)1, 4 Need A.C....Goldstein D.B. (2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Genome-wide association study identifies three new su sceptibility loci for esophageal squamous-cell carcinoma in Chinese populations . (PubMed id 21642993)4 Wu C....Lin D. (2011)
    7. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)4 Newton-Cheh C....Larson M.G. (2007)
    8. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)
    9. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10391 HGNC: 2256 AceView: CORO2B Ensembl:ENSG00000103647 euGenes: HUgn10391
    ECgene: CORO2B H-InvDB: CORO2B

    (According to HUGE)
    About This Section
    HUGE: KIAA0925

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CORO2B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CORO2B gene:
    Search GeneIP for patents involving CORO2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CORO2B  
     OriGene qPCR primer pairs and template standards for CORO2B   OriGene Protein Over-expression Lysate for CORO2B  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CORO2B  
     OriGene qSTAR qPCR primer pairs in human, mouse for CORO2B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CORO2B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CORO2B   OriGene Custom Protein Services for CORO2B  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CORO2B
     QIAGEN SeqTarget long-range PCR primers for resequencing CORO2B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CORO2B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CORO2B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CORO2B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CORO2B
     GenScript Custom Purified and Recombinant Proteins Services for CORO2B GenScript cDNA clones with any tag delivered in your preferred vector for CORO2B
     GenScript Custom Assay Services for CORO2B GenScript Custom Superior Antibodies Services for CORO2B
     GenScript Custom overexpressing Cell Line Services for CORO2B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CORO2B promoter
     Search Chromatin IP Primers for CORO2B
     RT2 qPCR Primer Assay in human, mouse, rat CORO2B
     GNC Network for CORO2B
     SABiosciences Custom PCR Arrays for CORO2B
     Search Tocris compounds for CORO2B (COR2B)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CORO2B antibodies
     CORO2B lysates
     Antibodies for CORO2B
     See all of Abcam's Antibodies, Kits and Proteins for CORO2B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CORO2B
     Antibodies for CORO2B
     ELISAs for CORO2B
     CLIAs for CORO2B
     Search LifeMap BioReagents cell lines for CORO2B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORO2B
     SwitchGear 3'UTR luciferase reporter plasmids for CORO2B
     SwitchGear Promoter luciferase reporter plasmids for CORO2B
     ThermoFisher Antibody for CORO2B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CORO2B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CORO2B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CORO2B
    Customized:
     lentivirus for stable overexpression of CORO2B
     lentivirus expression plasmids for stable overexpression of CORO2B
     adenovirus for overexpression of CORO2B
     LSBio Antibodies in human, mouse, rat for CORO2B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CORO2B gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4