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Aliases for CORO2B Gene

Aliases for CORO2B Gene

  • Coronin 2B 2 3 5
  • Coronin-Like Protein C 3 4
  • Clipin C 2 3
  • Coronin, Actin-Binding Protein, 2B 2
  • Coronin, Actin Binding Protein, 2B 3
  • Coronin, Actin-Binding, 2B 2
  • Protein FC96 4
  • Coronin-2B 3
  • Clipin-C 4
  • KIAA0925 4

External Ids for CORO2B Gene

Previous GeneCards Identifiers for CORO2B Gene

  • GC15P064711
  • GC15P061970
  • GC15P066450
  • GC15P066587
  • GC15P066658
  • GC15P068871
  • GC15P045742

Summaries for CORO2B Gene

GeneCards Summary for CORO2B Gene

CORO2B (Coronin 2B) is a Protein Coding gene. GO annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is CORO2A.

UniProtKB/Swiss-Prot for CORO2B Gene

  • May play a role in the reorganization of neuronal actin structure.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORO2B Gene

Genomics for CORO2B Gene

Regulatory Elements for CORO2B Gene

Enhancers for CORO2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G069087 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.3 +531.7 531690 6.0 HDGF ATF1 PKNOX1 ZNF133 GLI4 YBX1 ZNF2 ZBTB7B GATA2 FOS CORO2B LOC145694 NOX5 CLN6 ENSG00000259222 GC15M069102
GH15G068275 1.7 Ensembl ENCODE dbSUPER 13.3 -279.9 -279865 8.8 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF263 SP3 ENSG00000260657 SKOR1 PIAS1 CORO2B IQCH-AS1 NOX5 GC15M068298
GH15G069159 1.7 FANTOM5 ENCODE dbSUPER 13.3 +601.6 601612 2.7 CREB3L1 AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF416 ZNF263 SP3 CORO2B NOX5 PAQR5 GLCE LOC100421574
GH15G069451 1.7 Ensembl ENCODE dbSUPER 13.3 +893.9 893907 4.1 AGO1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF263 SP3 NFYC ZFP41 CORO2B NOX5 RPLP1 GC15M069460 ENSG00000207119
GH15G069467 1.5 Ensembl ENCODE dbSUPER 13.3 +909.5 909525 2.7 HDGF PKNOX1 ZNF493 SIN3A FEZF1 YBX1 TCF12 GLIS2 GATA2 CBX5 CORO2B LOC145694 NOX5 DRAIC PIR48489
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CORO2B on UCSC Golden Path with GeneCards custom track

Genomic Location for CORO2B Gene

68,559,275 bp from pter
68,727,806 bp from pter
168,532 bases
Plus strand

Genomic View for CORO2B Gene

Genes around CORO2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORO2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORO2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO2B Gene

Proteins for CORO2B Gene

  • Protein details for CORO2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K0W3
    • O94767
    • Q8TAN1

    Protein attributes for CORO2B Gene

    480 amino acids
    Molecular mass:
    54953 Da
    Quaternary structure:
    • Binds to F-actin and to vinculin.
    • Sequence=AAH26335.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA36341.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CORO2B Gene


neXtProt entry for CORO2B Gene

Post-translational modifications for CORO2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CORO2B Gene

No data available for DME Specific Peptides for CORO2B Gene

Domains & Families for CORO2B Gene

Gene Families for CORO2B Gene

Suggested Antigen Peptide Sequences for CORO2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat coronin family.
  • Belongs to the WD repeat coronin family.
genes like me logo Genes that share domains with CORO2B: view

Function for CORO2B Gene

Molecular function for CORO2B Gene

GENATLAS Biochemistry:
coronin 2B,homolog to Dictyostelium discoideum coronin,a soluble actin-binding protein,predominantly expressed in brain,accumulating at focal adhesions as well as at neurite tips and stress fibers where it associates with vinculin,suggesting that coronin 2B plays a specific role in cross-binding the actin cytoskeleton and plasma membrane
UniProtKB/Swiss-Prot Function:
May play a role in the reorganization of neuronal actin structure.

Gene Ontology (GO) - Molecular Function for CORO2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding NAS 10224093
GO:0005515 protein binding IPI 25416956
GO:0051015 actin filament binding IBA --
genes like me logo Genes that share ontologies with CORO2B: view
genes like me logo Genes that share phenotypes with CORO2B: view

Animal Model Products

CRISPR Products

miRNA for CORO2B Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CORO2B Gene

Localization for CORO2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CORO2B Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CORO2B gene
Compartment Confidence
cytoskeleton 3
cytosol 3
plasma membrane 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CORO2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0015629 actin cytoskeleton NAS 10224093
GO:0016020 membrane NAS 10224093
genes like me logo Genes that share ontologies with CORO2B: view

Pathways & Interactions for CORO2B Gene

SuperPathways for CORO2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for CORO2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030036 actin cytoskeleton organization NAS 10224093
genes like me logo Genes that share ontologies with CORO2B: view

No data available for Pathways by source and SIGNOR curated interactions for CORO2B Gene

Drugs & Compounds for CORO2B Gene

No Compound Related Data Available

Transcripts for CORO2B Gene

Unigene Clusters for CORO2B Gene

Coronin, actin binding protein, 2B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CORO2B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^
SP1: - - - - - - - -
SP2: -
SP3: - - - -
SP4: - -
SP5: - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP9: - -

ExUns: 18a · 18b · 18c · 18d

Relevant External Links for CORO2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CORO2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CORO2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CORO2B Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.0).

Protein differential expression in normal tissues from HIPED for CORO2B Gene

This gene is overexpressed in Frontal cortex (21.5), Retina (13.7), Spinal cord (9.7), and Fetal Brain (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CORO2B Gene

Protein tissue co-expression partners for CORO2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CORO2B Gene:


SOURCE GeneReport for Unigene cluster for CORO2B Gene:


mRNA Expression by UniProt/SwissProt for CORO2B Gene:

Tissue specificity: Expressed predominantly in brain.

Evidence on tissue expression from TISSUES for CORO2B Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with CORO2B: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CORO2B Gene

Orthologs for CORO2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CORO2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CORO2B 34 35
  • 99.44 (n)
(Canis familiaris)
Mammalia CORO2B 34 35
  • 93.75 (n)
(Bos Taurus)
Mammalia CORO2B 34 35
  • 92.97 (n)
(Mus musculus)
Mammalia Coro2b 34 16 35
  • 91.46 (n)
(Rattus norvegicus)
Mammalia Coro2b 34
  • 91.18 (n)
(Ornithorhynchus anatinus)
Mammalia CORO2B 35
  • 90 (a)
(Monodelphis domestica)
Mammalia CORO2B 35
  • 89 (a)
(Gallus gallus)
Aves CORO2B 34 35
  • 83.86 (n)
(Anolis carolinensis)
Reptilia CORO2B 35
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia coro2b 34
  • 75.6 (n)
(Danio rerio)
Actinopterygii coro2ba 34 35
  • 77.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta coro 35
  • 40 (a)
(Caenorhabditis elegans)
Secernentea cor-1 36 35
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRN1 35
  • 27 (a)
Species where no ortholog for CORO2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CORO2B Gene

Gene Tree for CORO2B (if available)
Gene Tree for CORO2B (if available)

Paralogs for CORO2B Gene

Paralogs for CORO2B Gene

(7) SIMAP similar genes for CORO2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CORO2B: view

Variants for CORO2B Gene

Sequence variations from dbSNP and Humsavar for CORO2B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_035878 A colorectal cancer sample
rs1000010858 -- 68,598,844(+) GAAGA(A/G)TGACT intron-variant
rs1000025885 -- 68,706,707(+) TGGTA(-/T)TTTTT intron-variant
rs1000076671 -- 68,595,192(+) TGGGG(G/T)CAGGC intron-variant
rs1000077004 -- 68,579,669(+) TGTGG(C/G)GATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CORO2B Gene

Variant ID Type Subtype PubMed ID
esv2487574 CNV deletion 19546169
esv2672538 CNV deletion 23128226
esv2749817 CNV deletion 23290073
esv2749818 CNV deletion 23290073
esv3306659 CNV mobile element insertion 20981092
esv3327513 CNV insertion 20981092
esv3351322 CNV insertion 20981092
esv33989 CNV gain 17666407
esv3552616 CNV deletion 23714750
esv3636807 CNV loss 21293372
esv3636808 CNV loss 21293372
nsv1070711 CNV deletion 25765185
nsv1108965 CNV deletion 24896259
nsv457189 CNV loss 19166990
nsv515835 CNV loss 19592680
nsv569807 CNV loss 21841781
nsv833046 CNV loss 17160897

Variation tolerance for CORO2B Gene

Residual Variation Intolerance Score: 13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CORO2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CORO2B Gene

Disorders for CORO2B Gene

Relevant External Links for CORO2B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CORO2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CORO2B Gene

Publications for CORO2B Gene

  1. A neurally enriched coronin-like protein, ClipinC, is a novel candidate for an actin cytoskeleton-cortical membrane-linking protein. (PMID: 10224093) Nakamura T. … Mori N. (J. Biol. Chem. 1999) 2 3 4 22 64
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need A.C. … Goldstein D.B. (Hum. Mol. Genet. 2009) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for CORO2B Gene

Sources for CORO2B Gene

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