CORO2B Gene
protein-coding GIFtS : 54
GCID: GC15 P068871
coronin, actin binding protein, 2B (Previous names: coronin, actin-binding protein, 2B )
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Aliasesfor CORO2B gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Coronin, Actin Binding Protein, 2B 1 2 Coronin, Actin-Binding Protein, 2B1 KIAA09251 3 Clipin C2 Coronin-Like Protein C2 3 Coronin-2B1 CLIPINC2 5 Clipin-C3 ClipinC1 Protein FC963
Export aliases for CORO2B gene to outside databases Previous GC identifers: GC15P064711 GC15P061970 GC15P066450 GC15P066587 GC15P066658 GC15P045742
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Summariesfor CORO2B gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: COR2B_HUMAN, Q9UQ03 Function : May play a role in the reorganization of neuronal actin structure
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Genomic Viewsfor CORO2B gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000015.9 NC_018926.1 NT_010194.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CORO2B gene promoter: ER-alpha USF1 USF2 USF-1:USF-2 CREB USF-1 deltaCREB TGIF AP-2alpha AP-2alphaA Other transcription factors Search SABiosciences Chromatin IP Primers for CORO2B Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat CORO2B
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 15q23 Ensembl cytogenetic band: 15q23 HGNC cytogenetic band: 15q22.31 CORO2B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 15 GeneLoc Exon Structure
GeneLoc location for GC15P068871: view genomic region
(about GC identifiers )
Start:
68,871,308 bp from pter
End:
69,020,145 bp from pter
Size:
148,838 bases
Orientation:
plus strand
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Proteinsfor CORO2B gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: COR2B_HUMAN, Q9UQ03 (See
protein sequence )Recommended Name: Coronin-2B Size : 480 amino acids; 54953 Da
Subunit : Binds to F-actin and to vinculin
Subcellular location : Cytoplasm, cytoskeleton (Probable)
Sequence caution : Sequence=AAH26335.1; Type=Erroneous initiation; Sequence=BAA36341.1; Type=Erroneous initiation;
Secondary accessions : A8K0W3 O94767 Q8TAN1Alternative splicing : 2 isoforms : Q9UQ03-1 Q9UQ03-2 Explore the universe of human proteins at neXtProt for CORO2B: NX_Q9UQ03 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9UQ03 CORO2B Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (3 alternative transcripts):
NP_001177385.1 NP_001177386.1 NP_006082.3 ENSEMBL proteins: ENSP00000261861 ENSP00000454783 ENSP00000446250 ENSP00000443819 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
CORO2B for ontologies About GeneDecksing CORO2B Antibody Products: Assay Products for CORO2B:
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Protein
Domains / Familiesfor CORO2B gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CORO2B for domains About GeneDecksing 5/7 InterPro domains/families (see all 7 ):
Graphical View of Domain Structure for InterPro Entry Q9UQ03 ProtoNet protein and cluster: Q9UQ03
UniProtKB/Swiss-Prot: COR2B_HUMAN, Q9UQ03 Similarity : Belongs to the WD repeat coronin familySimilarity : Contains 5 WD repeats
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Functionfor CORO2B gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: COR2B_HUMAN, Q9UQ03 Function : May play a role in the reorganization of neuronal actin structure
Genatlas biochemistry entry for CORO2B : coronin 2B,homolog to Dictyostelium discoideum coronin,a soluble actin-binding protein,predominantly expressed in brain,accumulating at focal adhesions as well as at neurite tips and stress fibers where it associates with vinculin,suggesting that coronin 2B plays a specific role in cross-binding the actin cytoskeleton and plasma membrane Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CORO2B (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CORO2B (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): CORO2B (NM_006091 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CORO2B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CORO2B
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORO2B
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
CORO2B for ontologies About GeneDecksing
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Pathways & Interactionsfor CORO2B gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CORO2B STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)4 Interacting proteins for CORO2B (Q9UQ03 2 , 3 ENSP00000261861 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0030036 actin cytoskeleton organization
NAS 10224093
CORO2B for ontologies About GeneDecksing
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Drugs & Compoundsfor CORO2B gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CORO2B Search CenterWatch for drugs/clinical trials and news about CORO2B / COR2B
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Transcriptsfor CORO2B gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CORO2B gene (3 alternative transcripts): NM_001190456.1 NM_001190457.1 NM_006091.4 Unigene Cluster for CORO2B:
Coronin, actin binding protein, 2B Hs.551213 [show with all ESTs ] Unigene Representative Sequence: NM_001190457 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000261861 (uc002arj.4 uc002ark.3 ) ENST00000566799 ENST00000540068 (uc021spj.1 )ENST00000543950 (uc010bic.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CORO2B (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CORO2B (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): CORO2B (NM_006091 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CORO2B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CORO2B
Additional cDNA sequence: AB010098.1 AB023142.1 AK289678.1 BC026335.1 BC128424.1
10 DOTS entries : DT.111233 DT.101958753
DT.121014804 DT.100679598 DT.121014817 DT.100757708 DT.121014807 DT.121014831 DT.91796748 DT.92421755 24/98 AceView cDNA sequences (see all 98 ):
W20512 BX090424 AB023142 CR609225 AB010098 CA396906 BQ440134 BP348937 BG702128 AI077487 BM695896 AI986153 AI480196 AI634066 AW235874 BF939649 AI201815 AL533625 AL079954 Z41417 BM465611 BQ185964 AI636642 N92783 GeneLoc Exon Structure 5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CORO2B (see all 10 ) About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ SP1 :     -   -   -   -   -   -                       -           -       SP2 :                                               -       SP3 :         -   -   -   -                                       SP4 :             -   -                                       SP5 :       -   -   -   -   -                                      
ExUns: 18a · 18b · 18c · 18d SP1 :         SP2 :         SP3 :         SP4 :         SP5 :        
ECgene alternative splicing isoforms for CORO2B
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Expression for CORO2B gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CORO2B expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCCGCCCTAC
About this image CORO2B expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See CORO2B Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CORO2B SOURCE GeneReport for Unigene cluster: Hs.551213 UniProtKB/Swiss-Prot: COR2B_HUMAN, Q9UQ03 Tissue specificity : Expressed predominantly in brain SABiosciences Custom PCR Arrays for CORO2B Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CORO2BBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat CORO2B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CORO2B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CORO2B In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORO2B
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Orthologsfor CORO2B gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for CORO2B gene from 6/21 species (see all 21 ) About this table
ENSEMBL Gene Tree for CORO2B (if available)TreeFam Gene Tree for CORO2B (if available)
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Paralogsfor CORO2B gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CORO2B gene CORO1B 2 CORO6 2 CORO1A 2 CORO7 2 CORO1C 2 CORO2A 2 7 SIMAP similar genes for CORO2B using alignment to 1 protein entry: COR2B_HUMAN :CORO2A CORO1C CORO1B DKFZp762I166 CORO6 CORO1A CORO7
CORO2B for paralogs About GeneDecksing
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Genomic Variantsfor CORO2B gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 15 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CORO2B (68871308 - 69020145 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for CORO2B 3 CNVs : 7069 102125 49581
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CORO2B
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Disorders
/ Diseasesfor CORO2B gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
CORO2B for disorders About GeneDecksing
OMIM gene information: 605002
OMIM disorders : --2 diseases for CORO2B : About MalaCards malaria neuronitis Human Genome Epidemiology (HuGE) Navigator: CORO2B (1 document)Export disorders for CORO2B gene to outside databases
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Publicationsfor CORO2B gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CORO2B gene, integrated from 9 sources (see all 11 ): (articles sorted by number of sources associating them with CORO2B) Utopia : connect your pdf to the dynamic world of online information
A neurally enriched coronin-like protein, ClipinC, is a novel candidate for an actin cytoskeleton-cortical membrane-linking protein. (PubMed id 10224093) 1 , 2 , 3, 9 Nakamura T....Mori N. (1999) Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032) 1 , 2 , 3 Nagase T.... Ohara O. (1999) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) A genome-wide study of common SNPs and CNVs in cognit ive performance in the CANTAB. (PubMed id 19734545) 1 Need A.C....Goldstein D.B. (2009) Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171) 2 Zody M.C....Nusbaum C. (2006) The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974) 2 Sjoeblom T.... Velculescu V.E. (2006) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070) 1 Stelzl U.... Wanker E.E. (2005) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004)
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External Searches for CORO2B gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CORO2B gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CORO2B gene
(According to HUGE )
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Specialized Databases showing CORO2B gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for CORO2B Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for CORO2B gene: Search GeneIP for patents involving CORO2B GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CORO2B gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for CORO2B OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CORO2B OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CORO2B OriGene Protein Over-expression Lysate for CORO2B Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CORO2B OriGene 3'-UTR Clone for CORO2B OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CORO2B OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CORO2B Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CORO2B OriGene Custom Protein Services for CORO2B OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CORO2B QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CORO2B QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat CORO2B QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CORO2B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CORO2B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CORO2B
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CORO2B Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORO2B
Search ThermoFisher Antibodies for CORO2B
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CORO2B
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Aliases for CORO2B
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