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Aliases for CORO2B Gene

Aliases for CORO2B Gene

  • Coronin, Actin Binding Protein, 2B 2 3
  • Coronin-Like Protein C 3 4
  • Clipin C 2 3
  • CLIPINC 3 6
  • Coronin, Actin-Binding Protein, 2B 2
  • Actin-Binding 2
  • Protein FC96 4
  • Coronin-2B 3
  • Clipin-C 4
  • KIAA0925 4
  • Coronin 2
  • 2B 2

External Ids for CORO2B Gene

Previous GeneCards Identifiers for CORO2B Gene

  • GC15P064711
  • GC15P061970
  • GC15P066450
  • GC15P066587
  • GC15P066658
  • GC15P068871
  • GC15P045742

Summaries for CORO2B Gene

GeneCards Summary for CORO2B Gene

CORO2B (Coronin, Actin Binding Protein, 2B) is a Protein Coding gene. GO annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is CORO6.

UniProtKB/Swiss-Prot for CORO2B Gene

  • May play a role in the reorganization of neuronal actin structure

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORO2B Gene

Genomics for CORO2B Gene

Regulatory Elements for CORO2B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CORO2B Gene

Start:
68,559,275 bp from pter
End:
68,727,806 bp from pter
Size:
168,532 bases
Orientation:
Plus strand

Genomic View for CORO2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CORO2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO2B Gene

Proteins for CORO2B Gene

  • Protein details for CORO2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQ03-COR2B_HUMAN
    Recommended name:
    Coronin-2B
    Protein Accession:
    Q9UQ03
    Secondary Accessions:
    • A8K0W3
    • O94767
    • Q8TAN1

    Protein attributes for CORO2B Gene

    Size:
    480 amino acids
    Molecular mass:
    54953 Da
    Quaternary structure:
    • Binds to F-actin and to vinculin
    SequenceCaution:
    • Sequence=AAH26335.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA36341.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CORO2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CORO2B Gene

Proteomics data for CORO2B Gene at MOPED

Post-translational modifications for CORO2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CORO2B Gene

No data available for DME Specific Peptides for CORO2B Gene

Domains for CORO2B Gene

Gene Families for CORO2B Gene

HGNC:
  • CORO :Coronins
  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for CORO2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UQ03

UniProtKB/Swiss-Prot:

COR2B_HUMAN :
  • Q9UQ03
Family:
  • Belongs to the WD repeat coronin family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with CORO2B: view

Function for CORO2B Gene

Molecular function for CORO2B Gene

GENATLAS Biochemistry: coronin 2B,homolog to Dictyostelium discoideum coronin,a soluble actin-binding protein,predominantly expressed in brain,accumulating at focal adhesions as well as at neurite tips and stress fibers where it associates with vinculin,suggesting that coronin 2B plays a specific role in cross-binding the actin cytoskeleton and plasma membrane
UniProtKB/Swiss-Prot Function: May play a role in the reorganization of neuronal actin structure

Gene Ontology (GO) - Molecular Function for CORO2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding NAS 10224093
GO:0005515 protein binding IPI 25416956
GO:0051015 actin filament binding IBA --
genes like me logo Genes that share ontologies with CORO2B: view

Animal Model Products

CRISPR Products

miRNA for CORO2B Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CORO2B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CORO2B Gene

Localization for CORO2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CORO2B Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CORO2B Gene COMPARTMENTS Subcellular localization image for CORO2B gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CORO2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0015629 actin cytoskeleton NAS 10224093
GO:0016020 membrane NAS 10224093
genes like me logo Genes that share ontologies with CORO2B: view

Pathways for CORO2B Gene

SuperPathways for CORO2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for CORO2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030036 actin cytoskeleton organization NAS 10224093
genes like me logo Genes that share ontologies with CORO2B: view

No data available for Pathways by source for CORO2B Gene

Transcripts for CORO2B Gene

Unigene Clusters for CORO2B Gene

Coronin, actin binding protein, 2B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CORO2B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CORO2B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^
SP1: - - - - - - - -
SP2: -
SP3: - - - -
SP4: - -
SP5: - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP8:
SP9: - -
SP10:

ExUns: 18a · 18b · 18c · 18d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CORO2B Gene

GeneLoc Exon Structure for
CORO2B
ECgene alternative splicing isoforms for
CORO2B

Expression for CORO2B Gene

mRNA expression in normal human tissues for CORO2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CORO2B Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CORO2B Gene

SOURCE GeneReport for Unigene cluster for CORO2B Gene Hs.551213

mRNA Expression by UniProt/SwissProt for CORO2B Gene

Q9UQ03-COR2B_HUMAN
Tissue specificity: Expressed predominantly in brain
genes like me logo Genes that share expressions with CORO2B: view

In Situ Assay Products

Orthologs for CORO2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CORO2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CORO2B 35
  • 99.44 (n)
  • 99.58 (a)
CORO2B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CORO2B 35
  • 92.97 (n)
  • 97.53 (a)
CORO2B 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CORO2B 35
  • 93.75 (n)
  • 98.95 (a)
CORO2B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Coro2b 35
  • 91.46 (n)
  • 98.12 (a)
Coro2b 16
Coro2b 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CORO2B 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CORO2B 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Coro2b 35
  • 91.18 (n)
  • 98.33 (a)
chicken
(Gallus gallus)
Aves CORO2B 35
  • 83.86 (n)
  • 93.92 (a)
CORO2B 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CORO2B 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia coro2b 35
  • 75.6 (n)
  • 85.65 (a)
zebrafish
(Danio rerio)
Actinopterygii coro2ba 35
  • 77.01 (n)
  • 87.21 (a)
coro2ba 36
  • 85 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta coro 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cor-1 36
  • 30 (a)
OneToMany
cor-1 37
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRN1 36
  • 27 (a)
OneToMany
Species with no ortholog for CORO2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CORO2B Gene

ENSEMBL:
Gene Tree for CORO2B (if available)
TreeFam:
Gene Tree for CORO2B (if available)

Paralogs for CORO2B Gene

Paralogs for CORO2B Gene

Selected SIMAP similar genes for CORO2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CORO2B: view

Variants for CORO2B Gene

Sequence variations from dbSNP and Humsavar for CORO2B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs4108 -- 68,659,230(-) actct(G/T)ccagg intron-variant
rs593719 -- 68,568,509(+) AGGAC(A/G)CTGGG intron-variant
rs595364 -- 68,570,799(+) CGTAG(G/T)TTTTT intron-variant
rs596373 -- 68,570,983(+) TGGCA(C/G)AAAGC intron-variant
rs597284 -- 68,582,231(+) AGCCC(C/T)GTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CORO2B Gene

Variant ID Type Subtype PubMed ID
esv2749817 CNV Deletion 23290073
nsv515835 CNV Loss 19592680
nsv833046 CNV Loss 17160897
esv2487574 CNV Deletion 19546169
esv2672538 CNV Deletion 23128226
esv2749818 CNV Deletion 23290073
nsv457189 CNV Loss 19166990
esv272597 CNV Insertion 20981092
esv270935 CNV Insertion 20981092
esv33989 CNV Gain 17666407

Relevant External Links for CORO2B Gene

HapMap Linkage Disequilibrium report
CORO2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CORO2B Gene

Disorders for CORO2B Gene

Relevant External Links for CORO2B

Genetic Association Database (GAD)
CORO2B
Human Genome Epidemiology (HuGE) Navigator
CORO2B
genes like me logo Genes that share disorders with CORO2B: view

No data available for UniProtKB/Swiss-Prot for CORO2B Gene

Publications for CORO2B Gene

  1. A neurally enriched coronin-like protein, ClipinC, is a novel candidate for an actin cytoskeleton-cortical membrane-linking protein. (PMID: 10224093) Nakamura T. … Mori N. (J. Biol. Chem. 1999) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need A.C. … Goldstein D.B. (Hum. Mol. Genet. 2009) 3 48
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for CORO2B Gene

Sources for CORO2B Gene

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