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Aliases for CORO2A Gene

Aliases for CORO2A Gene

  • Coronin, Actin Binding Protein, 2A 2 3
  • IR10 3 4 6
  • WDR2 3 4 6
  • Coronin, Actin-Binding Protein, 2A 2 3
  • WD Repeat-Containing Protein 2 3 4
  • Coronin-Like Protein B 2 3
  • WD-Repeat Protein 2 2 3
  • WD Protein IR10 2 3
  • Coronin 2A 2 3
  • Coronin-2A 3
  • CLIPINB 3

External Ids for CORO2A Gene

Summaries for CORO2A Gene

Entrez Gene Summary for CORO2A Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for CORO2A Gene

CORO2A (Coronin, Actin Binding Protein, 2A) is a Protein Coding gene. GO annotations related to this gene include actin filament binding. An important paralog of this gene is CORO6.

Gene Wiki entry for CORO2A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORO2A Gene

Genomics for CORO2A Gene

Genomic Location for CORO2A Gene

Start:
98,120,975 bp from pter
End:
98,192,674 bp from pter
Size:
71,700 bases
Orientation:
Minus strand

Genomic View for CORO2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CORO2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO2A Gene

Regulatory Elements for CORO2A Gene

Proteins for CORO2A Gene

  • Protein details for CORO2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92828-COR2A_HUMAN
    Recommended name:
    Coronin-2A
    Protein Accession:
    Q92828
    Secondary Accessions:
    • Q5TBR5
    • Q92829
    • Q9BWS5

    Protein attributes for CORO2A Gene

    Size:
    525 amino acids
    Molecular mass:
    59763 Da
    Quaternary structure:
    • Binds actin (By similarity). Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2.

neXtProt entry for CORO2A Gene

Proteomics data for CORO2A Gene at MOPED

Post-translational modifications for CORO2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CORO2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CORO2A Gene

Domains for CORO2A Gene

Gene Families for CORO2A Gene

HGNC:
  • WDR :WD repeat domain containing
  • CORO :Coronins

UniProtKB/Swiss-Prot:

COR2A_HUMAN
Family:
  • Belongs to the WD repeat coronin family.:
    • Q92828
Similarity:
  • Contains 7 WD repeats.:
    • Q92828
genes like me logo Genes that share domains with CORO2A: view

Function for CORO2A Gene

Molecular function for CORO2A Gene

GENATLAS Biochemistry: coronin 2A,homolog to Dictyostelium discoideum coronin,a soluble actin-binding protein,mainly expressed in epidermis,brain,putatively involved in protein interactions

Gene Ontology (GO) - Molecular Function for CORO2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0051015 actin filament binding IBA --
genes like me logo Genes that share ontologies with CORO2A: view

miRNA for CORO2A Gene

miRTarBase miRNAs that target CORO2A

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CORO2A Gene

Localization for CORO2A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CORO2A Gene COMPARTMENTS Subcellular localization image for CORO2A gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CORO2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015629 actin cytoskeleton IBA --
GO:0017053 transcriptional repressor complex IDA 12628926
genes like me logo Genes that share ontologies with CORO2A: view

Pathways for CORO2A Gene

SuperPathways for CORO2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for CORO2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030036 actin cytoskeleton organization IBA --
GO:0035556 intracellular signal transduction TAS 8985118
genes like me logo Genes that share ontologies with CORO2A: view

No data available for Pathways by source for CORO2A Gene

Transcripts for CORO2A Gene

Unigene Clusters for CORO2A Gene

Coronin, actin binding protein, 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CORO2A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - - -
SP2:
SP3: -
SP4: -
SP5:

Relevant External Links for CORO2A Gene

GeneLoc Exon Structure for
CORO2A
ECgene alternative splicing isoforms for
CORO2A

Expression for CORO2A Gene

mRNA expression in normal human tissues for CORO2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CORO2A Gene

This gene is overexpressed in Esophagus - Mucosa (4.4) and Colon - Transverse (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CORO2A Gene

SOURCE GeneReport for Unigene cluster for CORO2A Gene Hs.113094

genes like me logo Genes that share expressions with CORO2A: view

Orthologs for CORO2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CORO2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CORO2A 36
  • 99.37 (n)
  • 99.62 (a)
CORO2A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CORO2A 36
  • 87.68 (n)
  • 86.86 (a)
CORO2A 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CORO2A 36
  • 86.38 (n)
  • 84.59 (a)
CORO2A 37
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Coro2a 36
  • 84.96 (n)
  • 86.23 (a)
Coro2a 16
Coro2a 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CORO2A 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CORO2A 37
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Coro2a 36
  • 85.39 (n)
  • 87.26 (a)
chicken
(Gallus gallus)
Aves CORO2A 36
  • 71.67 (n)
  • 73.49 (a)
CORO2A 37
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CORO2A 37
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia coro2a 36
  • 66.86 (n)
  • 71.12 (a)
zebrafish
(Danio rerio)
Actinopterygii coro2a 36
  • 65.3 (n)
  • 66.67 (a)
coro2a 37
  • 63 (a)
OneToMany
CORO2A (2 of 2) 37
  • 52 (a)
OneToMany
wufc02b08 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007525 36
  • 57.53 (n)
  • 51.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta coro 37
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cor-1 37
  • 33 (a)
OneToMany
cor-1 38
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRN1 37
  • 30 (a)
OneToMany
Species with no ortholog for CORO2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CORO2A Gene

ENSEMBL:
Gene Tree for CORO2A (if available)
TreeFam:
Gene Tree for CORO2A (if available)

Paralogs for CORO2A Gene

Paralogs for CORO2A Gene

Selected SIMAP similar genes for CORO2A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CORO2A: view

Variants for CORO2A Gene

Sequence variations from dbSNP and Humsavar for CORO2A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs701378 -- 98,122,860(+) GTCTG(C/T)GTCCC utr-variant-3-prime
rs701379 -- 98,124,543(+) ATTCA(A/T)CAGAA utr-variant-3-prime
rs715910 -- 98,149,229(-) CGTTA(C/T)TTTTG intron-variant
rs735111 -- 98,133,161(-) AGTAC(A/G)ATTAG synonymous-codon, reference
rs751800 -- 98,122,282(+) TATGA(A/C)CATAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CORO2A Gene

Variant ID Type Subtype PubMed ID
nsv893613 CNV Gain 21882294
nsv520067 CNV Gain 19592680
esv2004305 CNV Deletion 18987734
nsv831663 CNV Loss 17160897

Relevant External Links for CORO2A Gene

HapMap Linkage Disequilibrium report
CORO2A

Disorders for CORO2A Gene

(1) University of Copenhagen DISEASES for CORO2A Gene

Relevant External Links for CORO2A

Genetic Association Database (GAD)
CORO2A
Human Genome Epidemiology (HuGE) Navigator
CORO2A
genes like me logo Genes that share disorders with CORO2A: view

No data available for UniProtKB/Swiss-Prot for CORO2A Gene

Publications for CORO2A Gene

  1. cDNA cloning of a novel WD repeat protein mapping to the 9q22.3 chromosomal region. (PMID: 8985118) Zaphiropoulos P.G. … Toftgard R. (DNA Cell Biol. 1996) 2 3 4 23
  2. Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway. (PMID: 19654210) Marshall T.W. … Bear J.E. (J. Cell. Sci. 2009) 3 23
  3. Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. (PMID: 12628926) Yoon H.-G. … Wong J. (EMBO J. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Common variants in FOXP1 are associated with generalized vitiligo. (PMID: 20526340) Jin Y. … Spritz R.A. (Nat. Genet. 2010) 3 49

Products for CORO2A Gene

Sources for CORO2A Gene

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