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Aliases for CORO2A Gene

Aliases for CORO2A Gene

  • Coronin 2A 2 2 3 5
  • WD Repeat-Containing Protein 2 3 4
  • Coronin-Like Protein B 2 3
  • WD-Repeat Protein 2 2 3
  • WD Protein IR10 2 3
  • IR10 3 4
  • WDR2 3 4
  • Coronin, Actin-Binding Protein, 2A 2
  • Coronin, Actin Binding Protein, 2A 3
  • Coronin-2A 3
  • CLIPINB 3

External Ids for CORO2A Gene

Previous GeneCards Identifiers for CORO2A Gene

  • GC09M091711
  • GC09M092629
  • GC09M094343
  • GC09M096266
  • GC09M096263
  • GC09M097966
  • GC09M099923
  • GC09M100883
  • GC09M070483

Summaries for CORO2A Gene

Entrez Gene Summary for CORO2A Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for CORO2A Gene

CORO2A (Coronin 2A) is a Protein Coding gene. GO annotations related to this gene include actin filament binding. An important paralog of this gene is CORO2B.

Gene Wiki entry for CORO2A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORO2A Gene

Genomics for CORO2A Gene

Regulatory Elements for CORO2A Gene

Enhancers for CORO2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F098117 1.5 FANTOM5 ENCODE 22.7 +72.4 72449 5.6 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 KLF13 NCBP1 ZNF322P1 LOC105376165 ENSG00000254633 CORO2A CCDC180 LOC100288125 LOC286359 LOC105376171 XPA
GH09F098221 1.7 FANTOM5 Ensembl ENCODE 17.6 -35.7 -35716 14.8 PKNOX1 ARNT ARID4B FEZF1 DMAP1 YY1 FOS SP5 SMARCA4 RCOR2 TBC1D2 CORO2A NCBP1 TRIM14 XPA CCDC180 MIR6854
GH09F098187 1.3 Ensembl ENCODE 17.7 +1.8 1785 6.2 ATF1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 GLIS2 ZNF143 ZNF263 SP3 TBC1D2 CORO2A TRIM14 PIR60537
GH09F098263 0.8 ENCODE 22.5 -71.3 -71260 0.2 GTF2F1 CTCF CBX3 SAP130 WRNIP1 ARID4B ZBTB40 ZNF2 RAD21 SCRT2 CORO2A TBC1D2 TRIM14 RNU6-918P GC09M098492
GH09F098141 1.5 FANTOM5 Ensembl ENCODE 11.7 +47.7 47737 6.4 PKNOX1 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 ZNF121 SLC30A9 ZNF263 TRIM14 CORO2A TBC1D2 NANS PIR60537
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CORO2A on UCSC Golden Path with GeneCards custom track

Promoters for CORO2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001309657 174 2201 ATF1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 GLIS2 ZNF143 ZNF263 SP3

Genomic Location for CORO2A Gene

Chromosome:
9
Start:
98,120,975 bp from pter
End:
98,192,674 bp from pter
Size:
71,700 bases
Orientation:
Minus strand

Genomic View for CORO2A Gene

Genes around CORO2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORO2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORO2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO2A Gene

Proteins for CORO2A Gene

  • Protein details for CORO2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92828-COR2A_HUMAN
    Recommended name:
    Coronin-2A
    Protein Accession:
    Q92828
    Secondary Accessions:
    • Q5TBR5
    • Q92829
    • Q9BWS5

    Protein attributes for CORO2A Gene

    Size:
    525 amino acids
    Molecular mass:
    59763 Da
    Quaternary structure:
    • Binds actin (By similarity). Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2.

neXtProt entry for CORO2A Gene

Post-translational modifications for CORO2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CORO2A Gene

Antibody Products

  • Abcam antibodies for CORO2A

No data available for DME Specific Peptides for CORO2A Gene

Domains & Families for CORO2A Gene

Gene Families for CORO2A Gene

Suggested Antigen Peptide Sequences for CORO2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92828

UniProtKB/Swiss-Prot:

COR2A_HUMAN :
  • Belongs to the WD repeat coronin family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat coronin family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with CORO2A: view

Function for CORO2A Gene

Molecular function for CORO2A Gene

GENATLAS Biochemistry:
coronin 2A,homolog to Dictyostelium discoideum coronin,a soluble actin-binding protein,mainly expressed in epidermis,brain,putatively involved in protein interactions

Gene Ontology (GO) - Molecular Function for CORO2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051015 actin filament binding IBA --
genes like me logo Genes that share ontologies with CORO2A: view
genes like me logo Genes that share phenotypes with CORO2A: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CORO2A Gene

Localization for CORO2A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CORO2A gene
Compartment Confidence
cytosol 4
cytoskeleton 3
plasma membrane 2
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CORO2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015629 actin cytoskeleton IBA --
GO:0017053 transcriptional repressor complex IDA 12628926
genes like me logo Genes that share ontologies with CORO2A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CORO2A Gene

Pathways & Interactions for CORO2A Gene

SuperPathways for CORO2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for CORO2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030036 actin cytoskeleton organization IBA --
GO:0035556 intracellular signal transduction TAS 8985118
genes like me logo Genes that share ontologies with CORO2A: view

No data available for Pathways by source and SIGNOR curated interactions for CORO2A Gene

Transcripts for CORO2A Gene

mRNA/cDNA for CORO2A Gene

Unigene Clusters for CORO2A Gene

Coronin, actin binding protein, 2A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CORO2A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - - -
SP2:
SP3: -
SP4: -
SP5:

Relevant External Links for CORO2A Gene

GeneLoc Exon Structure for
CORO2A
ECgene alternative splicing isoforms for
CORO2A

Expression for CORO2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CORO2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CORO2A Gene

This gene is overexpressed in Esophagus - Mucosa (x4.4) and Colon - Transverse (x4.3).

Protein differential expression in normal tissues from HIPED for CORO2A Gene

This gene is overexpressed in Testis (14.7), Peripheral blood mononuclear cells (13.5), and Lung (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CORO2A Gene



Protein tissue co-expression partners for CORO2A Gene

NURSA nuclear receptor signaling pathways regulating expression of CORO2A Gene:

CORO2A

SOURCE GeneReport for Unigene cluster for CORO2A Gene:

Hs.113094
genes like me logo Genes that share expression patterns with CORO2A: view

No data available for mRNA Expression by UniProt/SwissProt for CORO2A Gene

Orthologs for CORO2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CORO2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CORO2A 34 35
  • 99.37 (n)
cow
(Bos Taurus)
Mammalia CORO2A 34 35
  • 87.68 (n)
dog
(Canis familiaris)
Mammalia CORO2A 34 35
  • 86.38 (n)
rat
(Rattus norvegicus)
Mammalia Coro2a 34
  • 85.39 (n)
mouse
(Mus musculus)
Mammalia Coro2a 34 16 35
  • 84.96 (n)
oppossum
(Monodelphis domestica)
Mammalia CORO2A 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CORO2A 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves CORO2A 34 35
  • 71.67 (n)
lizard
(Anolis carolinensis)
Reptilia CORO2A 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia coro2a 34
  • 66.86 (n)
zebrafish
(Danio rerio)
Actinopterygii coro2a 34 35
  • 65.3 (n)
CORO2A (2 of 2) 35
  • 52 (a)
OneToMany
wufc02b08 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007525 34
  • 57.53 (n)
fruit fly
(Drosophila melanogaster)
Insecta coro 35
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cor-1 36 35
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRN1 35
  • 30 (a)
OneToMany
Species where no ortholog for CORO2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CORO2A Gene

ENSEMBL:
Gene Tree for CORO2A (if available)
TreeFam:
Gene Tree for CORO2A (if available)

Paralogs for CORO2A Gene

Paralogs for CORO2A Gene

(6) SIMAP similar genes for CORO2A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CORO2A: view

Variants for CORO2A Gene

Sequence variations from dbSNP and Humsavar for CORO2A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10118043 -- 98,161,190(+) CAGAG(A/G)AGGAG intron-variant
rs10124412 -- 98,161,426(+) GCGCG(C/T)GCCTG intron-variant
rs10217347 -- 98,183,302(+) TTGTC(C/T)CAAGA intron-variant
rs10217398 -- 98,184,938(+) TAAAG(C/T)GCCTC intron-variant
rs10217520 -- 98,183,876(+) gaatc(A/G)cttga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CORO2A Gene

Variant ID Type Subtype PubMed ID
nsv950915 CNV duplication 24416366
nsv831663 CNV loss 17160897
nsv520067 CNV gain 19592680
nsv474352 CNV novel sequence insertion 20440878
nsv1115213 CNV deletion 24896259
nsv1077166 CNV deletion 25765185
esv3621201 CNV gain 21293372
esv3573304 CNV loss 25503493
esv2004305 CNV deletion 18987734

Variation tolerance for CORO2A Gene

Residual Variation Intolerance Score: 35.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.59; 44.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CORO2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CORO2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CORO2A Gene

Disorders for CORO2A Gene

Relevant External Links for CORO2A

Genetic Association Database (GAD)
CORO2A
Human Genome Epidemiology (HuGE) Navigator
CORO2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CORO2A

No disorders were found for CORO2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CORO2A Gene

Publications for CORO2A Gene

  1. cDNA cloning of a novel WD repeat protein mapping to the 9q22.3 chromosomal region. (PMID: 8985118) Zaphiropoulos P.G. … Toftgard R. (DNA Cell Biol. 1996) 2 3 4 22 64
  2. Common variants in FOXP1 are associated with generalized vitiligo. (PMID: 20526340) Jin Y. … Spritz R.A. (Nat. Genet. 2010) 3 46 64
  3. Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway. (PMID: 19654210) Marshall T.W. … Bear J.E. (J. Cell. Sci. 2009) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. (PMID: 12628926) Yoon H.-G. … Wong J. (EMBO J. 2003) 3 4 64

Products for CORO2A Gene

Sources for CORO2A Gene

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