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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CORO2A Gene

protein-coding   GIFtS: 54
GCID: GC09M100883

coronin, actin binding protein, 2A

(Previous names: coronin, actin-binding protein, 2A )
 Explore 5 diseases affiliated with
CORO2A via our new
 Human Malady Compendium 
Biological research products
for CORO2A
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Coronin, Actin Binding Protein, 2A1 2     Coronin 2A2
IR101 2 3 5     Coronin-2A1
WDR21 2 3 5     Coronin-Like Protein B2
Coronin, Actin-Binding Protein, 2A1 2     WD Protein IR102
WD Repeat-Containing Protein 22 3     WD-Repeat Protein 22
CLIPINB2     

External Ids:    HGNC: 22551   Entrez Gene: 74642   Ensembl: ENSG000001067897   OMIM: 6021595   UniProtKB: Q928283   

Export aliases for CORO2A gene to outside databases

Previous GC identifers: GC09M091711 GC09M092629 GC09M094343 GC09M096266 GC09M096263 GC09M097966 GC09M099923 GC09M070483


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CORO2A:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately
40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or
multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle
progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a
structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting
that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene
generates 2 transcript variants. (provided by RefSeq, Jul 2008)

Gene Wiki entry for CORO2A


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CORO2A gene promoter:
         C/EBPbeta   MAZR   p53   GCNF   AP-4   E47   HEN1   GCNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCORO2A promoter sequence
   Search SABiosciences Chromatin IP Primers for CORO2A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CORO2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.3   Ensembl cytogenetic band:  9q22.33   HGNC cytogenetic band: 9q22.3

CORO2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CORO2A gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M100883:  view genomic region     (about GC identifiers)

Start:
100,883,257 bp from pter      End:
100,954,956 bp from pter
Size:
71,700 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: COR2A_HUMAN, Q92828 (See protein sequence)
Recommended Name: Coronin-2A  
Size: 525 amino acids; 59763 Da
Subunit: Binds actin (By similarity). Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2,
HDAC3, TBL1X, TBL1R, CORO2A and GPS2
Secondary accessions: Q5TBR5 Q92829 Q9BWS5

Explore the universe of human proteins at neXtProt for CORO2A: NX_Q92828

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92828

  • CORO2A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_003380.3  NP_438171.1  

    ENSEMBL proteins: 
     ENSP00000343746   ENSP00000364218  

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    Uscn Proteins for CORO2A

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0015629actin cytoskeleton IBA--
    GO:0017053transcriptional repressor complex IDA12628926


    CORO2A for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CORO2A for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR019775 WD40_repeat_CS
     IPR015049 DUF1900
     IPR001680 WD40_repeat
     IPR015505 Coronin
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q92828

    ProtoNet protein and cluster: Q92828

    1 Blocks protein family: IPB001680 G-protein beta WD-40 repeat signature

    UniProtKB/Swiss-Prot: COR2A_HUMAN, Q92828
    Similarity: Belongs to the WD repeat coronin family
    Similarity: Contains 5 WD repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:
         Genatlas biochemistry entry for CORO2A:
    coronin 2A,homolog to Dictyostelium discoideum coronin,a soluble actin-binding protein,mainly expressed in
    epidermis,brain,putatively involved in protein interactions

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    hsa-miR-140-5p hsa-miR-642a hsa-miR-520e hsa-miR-3607-3p hsa-miR-188-5p hsa-miR-30d hsa-miR-138-2* hsa-miR-3921
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051015actin filament binding IBA--


    CORO2A for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CORO2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for CORO2A (Q928283 ENSP000003437464) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC3O153793, ENSP000003029674I2D: score=1 STRING: ENSP00000302967
    TBL1XO609073, ENSP000002179644I2D: score=1 STRING: ENSP00000217964
    NCOR1O753763, ENSP000002687124I2D: score=1 STRING: ENSP00000268712
    NR1H2P550553, ENSP000002537274I2D: score=1 STRING: ENSP00000253727
    TBL1XR1Q9BZK73, ENSP000004055744I2D: score=1 STRING: ENSP00000405574
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030036actin cytoskeleton organization IBA--
    GO:0035556intracellular signal transduction TAS8985118


    CORO2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CORO2A
    Search CenterWatch for drugs/clinical trials and news about CORO2A / COR2A 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CORO2A gene (2 alternative transcripts): 
    NM_003389.3  NM_052820.3  

    Unigene Cluster for CORO2A:

    Coronin, actin binding protein, 2A
    Hs.113094  [show with all ESTs]
    Unigene Representative Sequence: NM_003389
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343933(uc004ayl.3) ENST00000375077(uc004ayk.3 uc004aym.3 uc004ayn.2)


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    hsa-miR-140-5p hsa-miR-642a hsa-miR-520e hsa-miR-3607-3p hsa-miR-188-5p hsa-miR-30d hsa-miR-138-2* hsa-miR-3921
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    Inhib. RNA
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    Additional cDNA sequence: 

    AK292788.1 BC000010.1 BC011690.2 

    6 DOTS entries:

    DT.95364113  DT.208545  DT.410256  DT.92421884  DT.97800490  DT.121161959 

    24/127 AceView cDNA sequences (see all 127):

    CD369628 BC000010 BQ936345 BM976925 BU634044 AI079558 AW445071 AI417239 
    BE302293 BX483465 AA724784 AA429793 BQ084560 BU689367 NM_003389 BM976329 
    BX113638 AA548421 BC011690 AA478415 BG473080 BU526830 NM_052820 AI743509 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CORO2A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b
    SP1:        -     -                                               -                                                   
    SP2:                                                                                                                  
    SP3:                                                                                                  -               
    SP4:              -                                                                                                   
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for CORO2A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CORO2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    CORO2A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleCumulus CellsOvary
    Skeletal MuscleHyoid Arch MusclesMuscle Progenitor CellsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMuscle Progenitor CellsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CORO2A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CORO2A

    SOURCE GeneReport for Unigene cluster: Hs.113094
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CORO2A gene from 4/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CORO2A1 coronin, actin binding protein, 2A 71.67(n)
    73.49(a)
      427373  XM_424946.3  XP_424946.3 
    lizard
    (Anolis carolinensis)
    Reptilia CORO2A6
    --
    73(a)
    1 ↔ 1
    GL343544.1(268748-295200)
    zebrafish
    (Danio rerio)
    Actinopterygii wufc02b082 wufc02b08 76.15(n)   323538  BC060941.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0075251 AGAP007525-PA 57.53(n)
    51.02(a)
      1269703  XM_564732.2  XP_564732.2 


    ENSEMBL Gene Tree for CORO2A (if available)
    TreeFam Gene Tree for CORO2A (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CORO2A gene
    CORO1B2  CORO62  CORO1A2  CORO72  CORO1C2  CORO2B2  
    6 SIMAP similar genes for CORO2A using alignment to 1 protein entry:     COR2A_HUMAN:
    CORO2B    CORO1C    CORO1B    CORO1A    CORO6    CORO7

    CORO2A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1419 NCBI SNPs in CORO2A are shown (see all 1419    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1155523801,2
    F,--100882849(+) AGTTGC/TCCCCC 5 -- us2k1 ds50011Minor allele frequency- T:0.02WA 118
    rs24879121,2
    C,F,A,H,--100882881(+) ACTTAA/TAAAGC 5 -- us2k1 ds500131Minor allele frequency- T:0.33NS EA NA WA CSA 3132
    rs126845681,2
    C,H--100882920(+) TCCGCA/CCTGCC 5 -- us2k1 ds50010--------
    rs1391050841,2
    --100882955(+) AGACTC/GGGGGA 5 -- us2k1 ds50010--------
    rs1877921771,2
    --100882974(+) TTACCA/CTGCTT 5 -- us2k1 ds50010--------
    rs1910966241,2
    --100883031(+) TACTCA/TGCAGG 5 -- us2k1 ds50010--------
    rs1439575531,2
    --100883052(+) ACTATA/CTTTTC 5 -- us2k1 ds50010--------
    rs1505088151,2
    --100883109(+) TCCCTA/TTCCTG 5 -- us2k1 ds50010--------
    rs1150048271,2
    --100883117(+) CTGGCC/TCTCCC 5 -- us2k1 ds50011Minor allele frequency- T:0.01WA 118
    rs1822648231,2
    --100883385(+) AACAAC/TATTAA 5 -- ut31 us2k10--------

    HapMap Linkage Disequilibrium report for CORO2A (100883257 - 100954956 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CORO2A
         1 Indel: 47759

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CORO2A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CORO2A for disorders           About GeneDecksing

    OMIM gene information: 602159    OMIM disorders: --

    5 diseases for CORO2A:    About MalaCards
    prader-willi syndrome    leptospirosis    angelman syndrome    vitiligo
    malaria

    1 disease from the University of Copenhagen DISEASES database for CORO2A:
    Leptospirosis
    Human Genome Epidemiology (HuGE) Navigator: CORO2A (1 document)

    Export disorders for CORO2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CORO2A gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with CORO2A)
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    1. cDNA cloning of a novel WD repeat protein mapping to the 9q22.3 chromosomal region. (PubMed id 8985118)1, 2, 3, 9 Zaphiropoulos P.G. and Toftgard R. (1996)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. (PubMed id 12628926)1, 2 Yoon H.-G....Wong J. (2003)
    4. Coronin 2A regulates a subset of focal-adhesion-turno ver events through the cofilin pathway. (PubMed id 19654210)1, 9 Marshall T.W....Bear J.E. (2009)
    5. Coronin 2A mediates actin-dependent de-repression of inflammatory response genes. (PubMed id 21331046)1 Huang W....Glass C.K. (2011)
    6. Common variants in FOXP1 are associated with generali zed vitiligo. (PubMed id 20526340)1 Jin Y....Spritz R.A. (2010)
    7. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
    8. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
    9. N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. (PubMed id 14527417)1 Yoon H.-G.... Wong J. (2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7464 HGNC: 2255 AceView: CORO2A Ensembl:ENSG00000106789 euGenes: HUgn7464
    ECgene: CORO2A H-InvDB: CORO2A

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CORO2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for CORO2A gene:
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