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Aliases for CORO2A Gene

Aliases for CORO2A Gene

  • Coronin 2A 2 3 2
  • Coronin, Actin-Binding Protein, 2A 2 3
  • Coronin, Actin Binding Protein, 2A 3 5
  • WD Repeat-Containing Protein 2 3 4
  • Coronin-Like Protein B 2 3
  • WD-Repeat Protein 2 2 3
  • WD Protein IR10 2 3
  • IR10 3 4
  • WDR2 3 4
  • CLIPINB 3

External Ids for CORO2A Gene

Previous GeneCards Identifiers for CORO2A Gene

  • GC09M091711
  • GC09M092629
  • GC09M094343
  • GC09M096266
  • GC09M096263
  • GC09M097966
  • GC09M099923
  • GC09M100883
  • GC09M070483

Summaries for CORO2A Gene

Entrez Gene Summary for CORO2A Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for CORO2A Gene

CORO2A (Coronin 2A) is a Protein Coding gene. GO annotations related to this gene include actin filament binding. An important paralog of this gene is CORO6.

Gene Wiki entry for CORO2A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORO2A Gene

Genomics for CORO2A Gene

Regulatory Elements for CORO2A Gene

Enhancers for CORO2A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CORO2A on UCSC Golden Path with GeneCards custom track

Promoters for CORO2A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CORO2A on UCSC Golden Path with GeneCards custom track

Genomic Location for CORO2A Gene

Chromosome:
9
Start:
98,120,975 bp from pter
End:
98,192,674 bp from pter
Size:
71,700 bases
Orientation:
Minus strand

Genomic View for CORO2A Gene

Genes around CORO2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORO2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORO2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO2A Gene

Proteins for CORO2A Gene

  • Protein details for CORO2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92828-COR2A_HUMAN
    Recommended name:
    Coronin-2A
    Protein Accession:
    Q92828
    Secondary Accessions:
    • Q5TBR5
    • Q92829
    • Q9BWS5

    Protein attributes for CORO2A Gene

    Size:
    525 amino acids
    Molecular mass:
    59763 Da
    Quaternary structure:
    • Binds actin (By similarity). Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2.

neXtProt entry for CORO2A Gene

Proteomics data for CORO2A Gene at MOPED

Post-translational modifications for CORO2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CORO2A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CORO2A Gene

Domains & Families for CORO2A Gene

Gene Families for CORO2A Gene

Suggested Antigen Peptide Sequences for CORO2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92828

UniProtKB/Swiss-Prot:

COR2A_HUMAN :
  • Belongs to the WD repeat coronin family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat coronin family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with CORO2A: view

Function for CORO2A Gene

Molecular function for CORO2A Gene

GENATLAS Biochemistry:
coronin 2A,homolog to Dictyostelium discoideum coronin,a soluble actin-binding protein,mainly expressed in epidermis,brain,putatively involved in protein interactions

Gene Ontology (GO) - Molecular Function for CORO2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051015 actin filament binding IBA --
genes like me logo Genes that share ontologies with CORO2A: view
genes like me logo Genes that share phenotypes with CORO2A: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CORO2A Gene

Localization for CORO2A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CORO2A Gene COMPARTMENTS Subcellular localization image for CORO2A gene
Compartment Confidence
cytosol 4
cytoskeleton 3
plasma membrane 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CORO2A Gene

Pathways & Interactions for CORO2A Gene

SuperPathways for CORO2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for CORO2A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CORO2A Gene

Drugs & Compounds for CORO2A Gene

No Compound Related Data Available

Transcripts for CORO2A Gene

Unigene Clusters for CORO2A Gene

Coronin, actin binding protein, 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CORO2A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - - -
SP2:
SP3: -
SP4: -
SP5:

Relevant External Links for CORO2A Gene

GeneLoc Exon Structure for
CORO2A
ECgene alternative splicing isoforms for
CORO2A

Expression for CORO2A Gene

mRNA expression in normal human tissues for CORO2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CORO2A Gene

This gene is overexpressed in Esophagus - Mucosa (x4.4) and Colon - Transverse (x4.3).

Protein differential expression in normal tissues from HIPED for CORO2A Gene

This gene is overexpressed in Testis (14.7), Peripheral blood mononuclear cells (13.5), and Lung (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CORO2A Gene



SOURCE GeneReport for Unigene cluster for CORO2A Gene Hs.113094

genes like me logo Genes that share expression patterns with CORO2A: view

Protein tissue co-expression partners for CORO2A Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CORO2A Gene

Orthologs for CORO2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CORO2A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CORO2A 35
  • 87.68 (n)
  • 86.86 (a)
CORO2A 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CORO2A 35
  • 86.38 (n)
  • 84.59 (a)
CORO2A 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Coro2a 35
  • 84.96 (n)
  • 86.23 (a)
Coro2a 16
Coro2a 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CORO2A 35
  • 99.37 (n)
  • 99.62 (a)
CORO2A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Coro2a 35
  • 85.39 (n)
  • 87.26 (a)
oppossum
(Monodelphis domestica)
Mammalia CORO2A 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CORO2A 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves CORO2A 35
  • 71.67 (n)
  • 73.49 (a)
CORO2A 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CORO2A 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia coro2a 35
  • 66.86 (n)
  • 71.12 (a)
zebrafish
(Danio rerio)
Actinopterygii coro2a 35
  • 65.3 (n)
  • 66.67 (a)
wufc02b08 35
coro2a 36
  • 63 (a)
OneToMany
CORO2A (2 of 2) 36
  • 52 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007525 35
  • 57.53 (n)
  • 51.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta coro 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cor-1 37
  • 43 (a)
cor-1 36
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRN1 36
  • 30 (a)
OneToMany
Species with no ortholog for CORO2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CORO2A Gene

ENSEMBL:
Gene Tree for CORO2A (if available)
TreeFam:
Gene Tree for CORO2A (if available)

Paralogs for CORO2A Gene

Paralogs for CORO2A Gene

(6) SIMAP similar genes for CORO2A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CORO2A: view

Variants for CORO2A Gene

Sequence variations from dbSNP and Humsavar for CORO2A Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs2231666 - 98,129,874(-) CATCC(A/G)CTACT reference, missense
rs35787916 - 98,124,868(+) GCCTT(A/C)GGATC reference, missense, stop-gained
rs701378 -- 98,122,860(+) GTCTG(C/T)GTCCC utr-variant-3-prime
rs701379 -- 98,124,543(+) ATTCA(A/T)CAGAA downstream-variant-500B, utr-variant-3-prime
rs715910 -- 98,149,229(-) CGTTA(C/T)TTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CORO2A Gene

Variant ID Type Subtype PubMed ID
nsv893613 CNV Gain 21882294
nsv520067 CNV Gain 19592680
esv2004305 CNV Deletion 18987734
nsv831663 CNV Loss 17160897

Variation tolerance for CORO2A Gene

Residual Variation Intolerance Score: 35.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.59; 44.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CORO2A Gene

Disorders for CORO2A Gene

Relevant External Links for CORO2A

Genetic Association Database (GAD)
CORO2A
Human Genome Epidemiology (HuGE) Navigator
CORO2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CORO2A

No disorders were found for CORO2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CORO2A Gene

Publications for CORO2A Gene

  1. cDNA cloning of a novel WD repeat protein mapping to the 9q22.3 chromosomal region. (PMID: 8985118) Zaphiropoulos P.G. … Toftgard R. (DNA Cell Biol. 1996) 2 3 4 23 67
  2. Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway. (PMID: 19654210) Marshall T.W. … Bear J.E. (J. Cell. Sci. 2009) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. The SUMO-specific isopeptidase SENP3 regulates MLL1/MLL2 methyltransferase complexes and controls osteogenic differentiation. (PMID: 24930734) Nayak A. … Muller S. (Mol. Cell 2014) 3

Products for CORO2A Gene

Sources for CORO2A Gene

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