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CORO1C Gene

protein-coding   GIFtS: 55
GCID: GC12M109038

Coronin, Actin Binding Protein, 1C

(Previous names: coronin, actin-binding protein, 1C)
  See CORO1C-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coronin, Actin Binding Protein, 1C1 2     coronin-32
Coronin, Actin-Binding Protein, 1C1 2     CRN23
HCRNN42     CRNN43
Coronin 1C2     Coronin-33
coronin-1C2     hCRNN43

External Ids:    HGNC: 22541   Entrez Gene: 236032   Ensembl: ENSG000001108807   OMIM: 6052695   UniProtKB: Q9ULV43   

Export aliases for CORO1C gene to outside databases

Previous GC identifers: GC12M108144 GC12M108919 GC12M108971 GC12M107541 GC12M106103


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CORO1C Gene:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of
approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation
of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular
processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Three
transcript variants encoding two different isoforms have been found for this gene. (provided by RefSeq, Feb 2013)

GeneCards Summary for CORO1C Gene:
CORO1C (coronin, actin binding protein, 1C) is a protein-coding gene. Diseases associated with CORO1C include coronin-1a deficiency. GO annotations related to this gene include actin filament binding. An important paralog of this gene is CORO1B.

UniProtKB/Swiss-Prot: COR1C_HUMAN, Q9ULV4
Function: May be involved in cytokinesis, motility, and signal transduction (By similarity)
Function: Isoform 3: Involved in myogenic differentiation

Gene Wiki entry for CORO1C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the CORO1C gene promoter:
         AML1a   Pax-2   Pax-2a   GATA-1   POU2F1   POU2F1a   POU2F1b   MRF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCORO1C promoter sequence
   Search Chromatin IP Primers for CORO1C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CORO1C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.1   Ensembl cytogenetic band:  12q24.11   HGNC cytogenetic band: 12q24.1

CORO1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CORO1C gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M109038:  view genomic region     (about GC identifiers)

Start:
109,038,885 bp from pter      End:
109,125,372 bp from pter
Size:
86,488 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: COR1C_HUMAN, Q9ULV4 (See protein sequence)
Recommended Name: Coronin-1C  
Size: 474 amino acids; 53249 Da
Subunit: Binds F-actin. Isoform 1 and isoform 2 appear as homotrimers, while isoform 3 seems to exist as monomers
Sequence caution: Sequence=CAB82406.1; Type=Erroneous initiation;
Secondary accessions: A7MAP0 A7MAP1 B3KU12 Q9NSK5
Alternative splicing: 3 isoforms:  Q9ULV4-1   Q9ULV4-2   Q9ULV4-3   (Exclusively expressed in well-differentiated myoblasts as well as in mature skeletal muscle)

Explore the universe of human proteins at neXtProt for CORO1C: NX_Q9ULV4

Explore proteomics data for CORO1C at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys311, Lys322, Lys391
  • Modification sites at PhosphoSitePlus

  • See CORO1C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001098707.1  NP_001263400.1  NP_055140.1  

    ENSEMBL proteins: 
     ENSP00000261401   ENSP00000438341   ENSP00000447337   ENSP00000415554   ENSP00000448130  
     ENSP00000447534   ENSP00000449658   ENSP00000449330   ENSP00000447989   ENSP00000448527  
     ENSP00000448195   ENSP00000447049   ENSP00000394496  

    CORO1C Human Recombinant Protein Products:

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    Novus Biologicals CORO1C Lysate
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    Cloud-Clone Corp. Proteins for CORO1C

     
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    Search eBioscience for ELISAs for CORO1C 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing
    CORO: Coronins

    Selected InterPro protein domains (see all 8):
     IPR019775 WD40_repeat_CS
     IPR015049 DUF1900
     IPR027333 CORO1A/1C
     IPR001680 WD40_repeat
     IPR015505 Coronin

    Graphical View of Domain Structure for InterPro Entry Q9ULV4

    ProtoNet protein and cluster: Q9ULV4

    UniProtKB/Swiss-Prot: COR1C_HUMAN, Q9ULV4
    Domain: The C-terminal coiled-coil domain is essential for cortical membrane localization and oligomerization
    Similarity: Belongs to the WD repeat coronin family
    Similarity: Contains 5 WD repeats


    Find genes that share domains with CORO1C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COR1C_HUMAN, Q9ULV4
    Function: May be involved in cytokinesis, motility, and signal transduction (By similarity)
    Function: Isoform 3: Involved in myogenic differentiation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0051015actin filament binding IBA--
         
    Find genes that share ontologies with CORO1C           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Coro1c):
     embryogenesis  limbs/digits/tail  nervous system 

    Find genes that share phenotypes with CORO1C           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CORO1C
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CORO1C
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    miRNA
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    miRTarBase miRNAs that target CORO1C:
    hsa-mir-375 (MIRT019935), hsa-mir-30a-5p (MIRT028565), hsa-mir-125a-5p (MIRT021303), hsa-mir-1301-3p (MIRT035980), hsa-mir-1 (MIRT001375)

    Block miRNA regulation of human, mouse, rat CORO1C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CORO1C (see all 87):
    hsa-miR-579 hsa-miR-607 hsa-miR-300 hsa-miR-128 hsa-miR-200a hsa-miR-219-5p hsa-miR-3122 hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmidCORO1C 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CORO1C

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: CORO1C (NM_014325)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CORO1C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CORO1C
    Addgene plasmids for CORO1C 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORO1C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COR1C_HUMAN, Q9ULV4: Cell membrane. Cell projection, lamellipodium. Cytoplasm, cytoskeleton. Note=All isoforms
    localize in a diffuse and punctate pattern in the cytosol and are highly enriched in F-actin-rich areas. Isoform
    3 colocalizes with the thin filaments of the sarcomere and with the postsynaptic area and the junctional
    sarcoplasm of motor end plates
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol3
    mitochondrion2
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--
    GO:0015629actin cytoskeleton IBA--
    GO:0030027lamellipodium IEA--

    Find genes that share ontologies with CORO1C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CORO1C
    Interactions:

        Search GeneGlobe Interaction Network for CORO1C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CORO1C (Q9ULV42, 3 ENSP000002614014) via UniProtKB, MINT, STRING, and/or I2D (see all 94)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3MINT-48394 I2D: score=2 
    RIPK3Q9Y5722, 3MINT-49089 I2D: score=2 
    USP45Q70EL23, ENSP000003333764I2D: score=2 STRING: ENSP00000333376
    MAP1LC3BQ9GZQ83, ENSP000002686074I2D: score=1 STRING: ENSP00000268607
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006909phagocytosis TAS9778037
    GO:0007165signal transduction TAS9778037
    GO:0030036actin cytoskeleton organization IBA--

    Find genes that share ontologies with CORO1C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CORO1C (COR1C)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CORO1C gene (3 alternative transcripts): 
    NM_001105237.2  NM_001276471.1  NM_014325.3  

    Unigene Cluster for CORO1C:

    Coronin, actin binding protein, 1C
    Hs.330384  [show with all ESTs]
    Unigene Representative Sequence: NM_001276471
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000261401(uc009zva.3 uc001tnj.3 uc010sxf.2) ENST00000541050
    ENST00000546705 ENST00000549384 ENST00000421578 ENST00000550542 ENST00000549772
    ENST00000549387 ENST00000552030 ENST00000547361 ENST00000552871 ENST00000547294
    ENST00000550032 ENST00000551550 ENST00000546571 ENST00000551044 ENST00000547170
    ENST00000551059
    miRNA
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    Block miRNA regulation of human, mouse, rat CORO1C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CORO1C (see all 87):
    hsa-miR-579 hsa-miR-607 hsa-miR-300 hsa-miR-128 hsa-miR-200a hsa-miR-219-5p hsa-miR-3122 hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmidCORO1C 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CORO1C
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    GenScript: all cDNA clones in your preferred vector: CORO1C (NM_014325)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CORO1C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CORO1C
    Addgene plasmids for CORO1C 
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    OriGene qPCR primer pairs and template standards for CORO1C
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CORO1C
      QuantiTect SYBR Green Assays in human, mouse, rat CORO1C
      QuantiFast Probe-based Assays in human, mouse, rat CORO1C

    Additional mRNA sequence: 

    AB030656.1 AB209909.1 AK023205.1 AK096363.1 AK223073.1 AK297463.1 AK304839.1 AK311315.1 
    AK316065.1 AK316504.1 AL162070.1 AM849477.1 AM849478.1 BC002342.2 BC133701.1 Z24726.1 

    18 DOTS entries:

    DT.100761117  DT.451615  DT.100816281  DT.100816278  DT.91776198  DT.448812  DT.75189391  DT.121197858 
    DT.91776172  DT.121197819  DT.121197872  DT.91776160  DT.91776166  DT.95145507  DT.95354818  DT.97864367 
    DT.121197874  DT.91816988 

    Selected AceView cDNA sequences (see all 490):

    AI301550 BQ772931 AA126947 C01700 BG740228 AA633787 CR625590 BE280543 
    BQ423965 AA687614 BQ231788 BU727193 BU502688 AU122788 AW026709 BQ421386 
    BM467838 BM915598 AA602334 BQ228349 BU848769 CA421545 CD364676 NM_014325 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CORO1C (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13
    SP1:              -     -     -     -     -           -                                                     -                     
    SP2:                          -     -     -           -                                                     -                     
    SP3:              -     -     -     -                 -                                                                           
    SP4:                                -     -           -                                                                           
    SP5:                                                  -                                                                           


    ECgene alternative splicing isoforms for CORO1C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CORO1C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACATCCCAGA
    CORO1C Expression
    About this image


    CORO1C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Lung (Respiratory System)
     
     Esophagus (Gastrointestinal Tract)
     
     Gall Bladder (Hepatobiliary System)
     
     Uterus (Reproductive System)
    CORO1C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CORO1C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.330384

    UniProtKB/Swiss-Prot: COR1C_HUMAN, Q9ULV4
    Tissue specificity: Ubiquitous

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    QuantiFast Probe-based Assays in human, mouse, rat CORO1C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORO1C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CORO1C gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Coro1c1 , 5 coronin, actin binding protein 1C1, 5 88.68(n)1
    97.47(a)1
      5 (55.64 cM)5
    237901  NM_011779.31  NP_035909.21 
     1138424365 
    chicken
    (Gallus gallus)
    Aves CORO1C1 coronin, actin binding protein, 1C 82.1(n)
    94.71(a)
      416893  NM_001277869.1  NP_001264798.1 
    lizard
    (Anolis carolinensis)
    Reptilia CORO1C6
    coronin, actin binding protein, 1C
    69(a)
    1 ↔ 1
    GL343913.1(4282-29807)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.9082 Xenopus laevis mRNA for coronin homolog, complete cds, more 79.23(n)    AB025246.1 
    zebrafish
    (Danio rerio)
    Actinopterygii coro1c2 coronin, actin binding protein, 1C 79.78(n)   317741  BC045340.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta coro1 , 3 actin binding3
    coro1
    54(a)3
    57.69(n)1
    56.68(a)1
      42D43
    355961  NM_001273814.11  NP_001260743.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cor-11 , 3 Coronin (beta transducin)3
    cor-11
    51(a)3
    55.85(n)1
    52.62(a)1
      III(10320798-10326235)3
    1764401  NM_171893.31  NP_741270.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CRN1(YLR429W)4
    CRN11
    Coronin, cortical actin cytoskeletal component that more4
    CRN11
    49.83(n)1
    43.01(a)1
      12(990777-992732)4
    8511481, 4  NP_013533.11, 4 


    ENSEMBL Gene Tree for CORO1C (if available)
    TreeFam Gene Tree for CORO1C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CORO1C gene
    CORO1B2  CORO7-PAM162  CORO1A2  CORO62  CORO72  CORO2B2  CORO2A2  
    12 SIMAP similar genes for CORO1C using alignment to 10 protein entries:     COR1C_HUMAN (see all proteins):
    CORO1B    CORO6    CORO1A    DKFZp762I166    CORO2B    WDR33
    CORO2A    PRPF4    CORO7    CORO7-PAM16    SNRNP40    WDR26

    Find genes that share paralogs with CORO1C           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for CORO1C
    PGOHUM00000239921 PGOHUM00000245130 PGOHUM00000240600 PGOHUM00000241412


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CORO1C (see all 1581)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1456185731,2
    --109038521(+) CCATGA/CAGCGA 3 -- ds50010--------
    rs104507651,2
    C--109038527(+) AGCGAA/GGGTTG 3 -- ds50010--------
    rs104507661,2
    C,F--109038626(+) ACCCCA/GTCCCA 3 -- ds50011Minor allele frequency- G:0.01WA 118
    rs104507671,2
    C--109038632(+) TCCCAA/GGACAC 3 -- ds50010--------
    rs1932401731,2
    --109038720(+) GAGACC/GTCACT 3 -- ds50010--------
    rs1477459411,2
    --109038773(+) ACCCCC/TGGAGA 3 -- ds50010--------
    rs1846981501,2
    C--109038774(+) CCCCCA/GGAGAG 3 -- ds50010--------
    rs734065721,2
    C,F--109038808(+) CCAAAG/ATCAGA 3 -- ds50012Minor allele frequency- A:0.04WA 120
    rs1425328891,2
    C--109038916(+) GAAAAC/TGGAAG 3 -- ut310--------
    rs2011631221,2
    C--109039026(-) TTTGTC/TTTTTT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for CORO1C (109038885 - 109125372 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CORO1C: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CORO1C
    DNA2.0 Custom Variant and Variant Library Synthesis for CORO1C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605269    OMIM disorders: --

    1 disease for CORO1C:    
    About MalaCards
    coronin-1a deficiency

    1 disease from the University of Copenhagen DISEASES database for CORO1C:
    coronin-1A deficiency

    Find genes that share disorders with CORO1C           About GenesLikeMe

    Genetic Association Database (GAD): CORO1C
    Human Genome Epidemiology (HuGE) Navigator: CORO1C (4 documents)

    Export disorders for CORO1C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CORO1C gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with CORO1C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and chromosomal assignment of a novel human gene, CORO1C, homologous to coronin-like actin-binding proteins. (PubMed id 10828594)1, 2, 9 Iizaka M.... Nakamura Y. (Cytogenet. Cell Genet. 2000)
    2. Oligomerization, F-actin interaction, and membrane association of the ubiquitous mammalian coronin 3 are mediated by its carboxyl terminus. (PubMed id 12377779)1, 2, 9 Spoerl Z....Hasse A. (J. Biol. Chem. 2002)
    3. Structural and functional diversity of novel coronin 1C (CRN2) isoforms in muscle. (PubMed id 19651142)1, 2, 9 Xavier C.P.... Clemen C.S. (J. Mol. Biol. 2009)
    4. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    6. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The coronin family of actin-associated proteins. (PubMed id 10461187)1, 3 de Hostos E.L. (Trends Cell Biol. 1999)
    10. Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein. (PubMed id 9778037)1, 3 Okumura M....Thomas M.L. (DNA Cell Biol. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23603 HGNC: 2254 AceView: CORO1C Ensembl:ENSG00000110880 euGenes: HUgn23603
    ECgene: CORO1C H-InvDB: CORO1C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CORO1C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CORO1C gene:
    Search GeneIP for patents involving CORO1C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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