Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CORO1C Gene

protein-coding   GIFtS: 55
GCID: GC12M109038

Coronin, Actin Binding Protein, 1C

(Previous names: coronin, actin-binding protein, 1C)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coronin, Actin Binding Protein, 1C1 2     coronin-32
Coronin, Actin-Binding Protein, 1C1 2     CRNN43
HCRNN42     Coronin-33
Coronin 1C2     hCRNN43
coronin-1C2     

External Ids:    HGNC: 22541   Entrez Gene: 236032   Ensembl: ENSG000001108807   OMIM: 6052695   UniProtKB: Q9ULV43   

Export aliases for CORO1C gene to outside databases

Previous GC identifers: GC12M108144 GC12M108919 GC12M108971 GC12M107541 GC12M106103


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CORO1C Gene:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of
approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation
of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular
processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Three
transcript variants encoding two different isoforms have been found for this gene. (provided by RefSeq, Feb 2013)

GeneCards Summary for CORO1C Gene: 
CORO1C (coronin, actin binding protein, 1C) is a protein-coding gene. Diseases associated with CORO1C include coronin-1a deficiency, and primary effusion lymphoma. GO annotations related to this gene include actin filament binding. An important paralog of this gene is CORO1B.

UniProtKB/Swiss-Prot: COR1C_HUMAN, Q9ULV4
Function: May be involved in cytokinesis, motility, and signal transduction (By similarity)

Gene Wiki entry for CORO1C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CORO1C gene promoter:
         AML1a   Pax-2   Pax-2a   GATA-1   POU2F1   POU2F1a   POU2F1b   MRF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCORO1C promoter sequence
   Search SABiosciences Chromatin IP Primers for CORO1C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CORO1C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.1   Ensembl cytogenetic band:  12q24.11   HGNC cytogenetic band: 12q24.1

CORO1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CORO1C gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M109038:  view genomic region     (about GC identifiers)

Start:
109,038,885 bp from pter      End:
109,125,372 bp from pter
Size:
86,488 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: COR1C_HUMAN, Q9ULV4 (See protein sequence)
Recommended Name: Coronin-1C  
Size: 474 amino acids; 53249 Da
Subunit: Binds actin
Sequence caution: Sequence=CAB82406.1; Type=Erroneous initiation;
Secondary accessions: B3KU12 Q9NSK5

Explore the universe of human proteins at neXtProt for CORO1C: NX_Q9ULV4

Explore proteomics data for CORO1C at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9ULV4

  • CORO1C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CORO1C Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001098707.1  NP_001263400.1  NP_055140.1  

    ENSEMBL proteins: 
     ENSP00000261401   ENSP00000438341   ENSP00000447337   ENSP00000415554   ENSP00000448130  
     ENSP00000447534   ENSP00000449658   ENSP00000449330   ENSP00000447989   ENSP00000448527  
     ENSP00000448195   ENSP00000447049   ENSP00000394496  

    Human Recombinant Protein Products for CORO1C: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CORO1C
    OriGene Protein Over-expression Lysate for CORO1C
    OriGene MassSpec for CORO1C 
    OriGene Custom Protein Services for CORO1C
    GenScript Custom Purified and Recombinant Proteins Services for CORO1C
    Novus Biologicals CORO1C Proteins
    Novus Biologicals CORO1C Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CORO1C 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--
    GO:0015629actin cytoskeleton IBA--
    GO:0030027lamellipodium IEA--

    CORO1C for ontologies           About GeneDecksing



    CORO1C Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CORO1C
    OriGene Custom Antibody Services for CORO1C
    GenScript Custom Superior Antibodies Services for CORO1C
    Novus Biologicals CORO1C Antibodies
    Abcam antibodies for CORO1C
    Cloud-Clone Corp. Antibodies for CORO1C 
    ThermoFisher Antibody for CORO1C
    LSBio Antibodies in human, mouse, rat for CORO1C 

    Assay Products for CORO1C: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CORO1C
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CORO1C
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CORO1C 
    Cloud-Clone Corp. CLIAs for CORO1C


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing
    CORO: Coronins

    5/8 InterPro protein domains (see all 8):
     IPR019775 WD40_repeat_CS
     IPR015049 DUF1900
     IPR027333 CORO1C
     IPR001680 WD40_repeat
     IPR015505 Coronin

    Graphical View of Domain Structure for InterPro Entry Q9ULV4

    ProtoNet protein and cluster: Q9ULV4

    UniProtKB/Swiss-Prot: COR1C_HUMAN, Q9ULV4
    Similarity: Belongs to the WD repeat coronin family
    Similarity: Contains 4 WD repeats


    CORO1C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COR1C_HUMAN, Q9ULV4
    Function: May be involved in cytokinesis, motility, and signal transduction (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0051015actin filament binding IBA--
         
    CORO1C for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Coro1c):
     embryogenesis  limbs/digits/tail  nervous system 

    CORO1C for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CORO1C 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CORO1C

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CORO1C 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CORO1C 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CORO1C:
    hsa-mir-1 (MIRT001375)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CORO1C
    8/87 QIAGEN miScript miRNA Assays for microRNAs that regulate CORO1C (see all 87):
    hsa-miR-579 hsa-miR-607 hsa-miR-300 hsa-miR-128 hsa-miR-200a hsa-miR-219-5p hsa-miR-3122 hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmidCORO1C 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CORO1C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CORO1C

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CORO1C
    Sirion Biotech Customized adenovirus for overexpression of CORO1C

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CORO1C (see all 7)
    OriGene ORF clones in mouse, rat for CORO1C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CORO1C (NM_014325)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CORO1C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CORO1C
    Sirion Biotech Customized lentivirus for stable overexpression of CORO1C 
                         Customized lentivirus expression plasmids for stable overexpression of CORO1C 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CORO1C
    Search LifeMap BioReagents cell lines for CORO1C
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORO1C


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CORO1C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/25 Interacting proteins for CORO1C (Q9ULV42, 3 ENSP000002614014) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3MINT-48394 I2D: score=2 
    RIPK3Q9Y5722, 3MINT-49089 I2D: score=2 
    USP45Q70EL23, ENSP000003333764I2D: score=2 STRING: ENSP00000333376
    MAP1LC3BQ9GZQ83, ENSP000002686074I2D: score=1 STRING: ENSP00000268607
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006909phagocytosis TAS9778037
    GO:0007165signal transduction TAS9778037
    GO:0030036actin cytoskeleton organization IBA--

    CORO1C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CORO1C (COR1C)

    Search CenterWatch for drugs/clinical trials and news about CORO1C / COR1C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CORO1C gene (3 alternative transcripts): 
    NM_001105237.2  NM_001276471.1  NM_014325.3  

    Unigene Cluster for CORO1C:

    Coronin, actin binding protein, 1C
    Hs.330384  [show with all ESTs]
    Unigene Representative Sequence: NM_001276471
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000261401(uc009zva.3 uc001tnj.3 uc010sxf.2) ENST00000541050
    ENST00000546705 ENST00000549384 ENST00000421578 ENST00000550542 ENST00000549772
    ENST00000549387 ENST00000552030 ENST00000547361 ENST00000552871 ENST00000547294
    ENST00000550032 ENST00000551550 ENST00000546571 ENST00000551044 ENST00000547170
    ENST00000551059
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CORO1C
    8/87 QIAGEN miScript miRNA Assays for microRNAs that regulate CORO1C (see all 87):
    hsa-miR-579 hsa-miR-607 hsa-miR-300 hsa-miR-128 hsa-miR-200a hsa-miR-219-5p hsa-miR-3122 hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmidCORO1C 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CORO1C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CORO1C
    Clone
    Products:
         
    OriGene clones in human, mouse for CORO1C (see all 7)
    OriGene ORF clones in mouse, rat for CORO1C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CORO1C (NM_014325)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CORO1C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CORO1C
    Sirion Biotech Customized lentivirus for stable overexpression of CORO1C 
                         Customized lentivirus expression plasmids for stable overexpression of CORO1C 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CORO1C
    OriGene qSTAR qPCR primer pairs in human, mouse for CORO1C
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CORO1C
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CORO1C
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CORO1C

    Additional mRNA sequence: 

    AB030656.1 AB209909.1 AK023205.1 AK096363.1 AK223073.1 AK297463.1 AK304839.1 AK311315.1 
    AK316065.1 AK316504.1 AL162070.1 AM849477.1 AM849478.1 BC002342.2 BC133701.1 Z24726.1 

    18 DOTS entries:

    DT.100761117  DT.451615  DT.100816281  DT.100816278  DT.91776198  DT.448812  DT.75189391  DT.121197858 
    DT.91776172  DT.121197819  DT.121197872  DT.91776160  DT.91776166  DT.95145507  DT.95354818  DT.97864367 
    DT.121197874  DT.91816988 

    24/490 AceView cDNA sequences (see all 490):

    BQ434620 AU131982 BM976535 BP365495 AA126947 BC002342 BI870717 AW390655 
    BG116475 AA505602 BQ772931 BM761399 BP335469 NM_014325 BM797408 BQ228349 
    BQ421386 AI301550 BU848769 CR616176 BP365738 C01700 BQ109345 BX324760 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CORO1C (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13
    SP1:              -     -     -     -     -           -                                                     -                     
    SP2:                          -     -     -           -                                                     -                     
    SP3:              -     -     -     -                 -                                                                           
    SP4:                                -     -           -                                                                           
    SP5:                                                  -                                                                           


    ECgene alternative splicing isoforms for CORO1C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CORO1C expression in normal human tissues (normalized intensities)      CORO1C embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACATCCCAGA
    CORO1C Expression
    About this image


    CORO1C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot

     -- (Gastrointestinal Tract)
             pharynx   

    See CORO1C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CORO1C

    SOURCE GeneReport for Unigene cluster: Hs.330384

    UniProtKB/Swiss-Prot: COR1C_HUMAN, Q9ULV4
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for CORO1C
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CORO1C
    OriGene qSTAR qPCR primer pairs in human, mouse for CORO1C
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CORO1C
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CORO1C
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CORO1C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORO1C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CORO1C gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Coro1c1 , 5 coronin, actin binding protein 1C1, 5 88.68(n)1
    97.47(a)1
      5 (55.64 cM)5
    237901  NM_011779.31  NP_035909.21 
     1138424365 
    chicken
    (Gallus gallus)
    Aves CORO1C1 coronin, actin binding protein, 1C 82.03(n)
    94.71(a)
      416893  NM_001039265.1  NP_001034354.1 
    lizard
    (Anolis carolinensis)
    Reptilia CORO1C6
    Coronin
    68(a)
    1 ↔ 1
    GL343913.1(4282-29807)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.9082 Xenopus laevis mRNA for coronin homolog, complete cds, more 79.23(n)    AB025246.1 
    zebrafish
    (Danio rerio)
    Actinopterygii coro1c2 coronin, actin binding protein, 1C 79.78(n)   317741  BC045340.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta coro1 , 3 actin binding3
    CG9446-PA1
    54(a)3
    57.86(n)1
    56.93(a)1
      42D43
    355961  NM_206031.11  NP_995753.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cor-11 , 3 Coronin (beta transducin)3
    Protein COR-11
    51(a)3
    55.85(n)1
    52.62(a)1
      III(10320798-10326235)3
    1764401  NM_171226.21  NP_741268.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CRN1(YLR429W)4 Coronin, cortical actin cytoskeletal component that more   --   12(990777-992732) 851148  NP_013533.1 


    ENSEMBL Gene Tree for CORO1C (if available)
    TreeFam Gene Tree for CORO1C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CORO1C gene
    CORO1B2  CORO7-PAM162  CORO1A2  CORO62  CORO72  CORO2B2  CORO2A2  
    12 SIMAP similar genes for CORO1C using alignment to 12 protein entries:     COR1C_HUMAN (see all proteins):
    CORO1B    CORO1A    CORO6    DKFZp762I166    WDR33    CORO2B
    CORO2A    PRPF4    CORO7    CORO7-PAM16    SNRNP40    WDR26

    CORO1C for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for CORO1C
    PGOHUM00000239921 PGOHUM00000245130 PGOHUM00000240600 PGOHUM00000241412


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1581 SNPs in CORO1C are shown (see all 1581)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1456185731,2
    --109038521(+) CCATGA/CAGCGA 3 -- ds50010--------
    rs104507651,2
    C--109038527(+) AGCGAA/GGGTTG 3 -- ds50010--------
    rs104507661,2
    C,F--109038626(+) ACCCCA/GTCCCA 3 -- ds50011Minor allele frequency- G:0.01WA 118
    rs104507671,2
    C--109038632(+) TCCCAA/GGACAC 3 -- ds50010--------
    rs1932401731,2
    --109038720(+) GAGACC/GTCACT 3 -- ds50010--------
    rs1477459411,2
    --109038773(+) ACCCCC/TGGAGA 3 -- ds50010--------
    rs1846981501,2
    C--109038774(+) CCCCCA/GGAGAG 3 -- ds50010--------
    rs734065721,2
    C,F--109038808(+) CCAAAG/ATCAGA 3 -- ds50012Minor allele frequency- A:0.04WA 120
    rs1425328891,2
    C--109038916(+) GAAAAC/TGGAAG 3 -- ut310--------
    rs2011631221,2
    C--109039026(-) TTTGTC/TTTTTT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for CORO1C (109038885 - 109125372 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CORO1C: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CORO1C
    DNA2.0 Custom Variant and Variant Library Synthesis for CORO1C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605269    OMIM disorders: --

    5 diseases for CORO1C:    About MalaCards
    coronin-1a deficiency    primary effusion lymphoma    meningioma    pancreatitis
    leukemia

    1 disease from the University of Copenhagen DISEASES database for CORO1C:
    coronin-1A deficiency

    CORO1C for disorders           About GeneDecksing

    Genetic Association Database (GAD): CORO1C
    Human Genome Epidemiology (HuGE) Navigator: CORO1C (4 documents)

    Export disorders for CORO1C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CORO1C gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with CORO1C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and chromosomal assignment of a novel human gene, CORO1C, homologous to coronin-like actin-binding proteins. (PubMed id 10828594)1, 2, 9 Iizaka M.... Nakamura Y. (2000)
    2. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    3. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The coronin family of actin-associated proteins. (PubMed id 10461187)1, 3 de Hostos E.L. (1999)
    8. Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein. (PubMed id 9778037)1, 3 Okumura M....Thomas M.L. (1998)
    9. Coronin 3 involvement in F-actin-dependent processes at the cell cortex. (PubMed id 17274980)1, 9 Rosentreter A....Clemen C.S. (2007)
    10. Coronin 1C negatively regulates cell-matrix adhesion and motility of intestinal epithelial cells. (PubMed id 19913511)1, 9 Samarin S.N....Nusrat A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23603 HGNC: 2254 AceView: CORO1C Ensembl:ENSG00000110880 euGenes: HUgn23603
    ECgene: CORO1C H-InvDB: CORO1C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CORO1C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CORO1C gene:
    Search GeneIP for patents involving CORO1C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CORO1C   OriGene RNAi products in human, mouse, rat for CORO1C  
     OriGene qPCR primer pairs and template standards for CORO1C   OriGene Protein Over-expression Lysate for CORO1C  
     OriGene MassSpec something-or-other for CORO1C   OriGene clones in human, mouse for CORO1C  
     OriGene qSTAR qPCR primer pairs in human, mouse for CORO1C   OriGene Purified Protein for CORO1C  
     OriGene ORF clones in mouse, rat for CORO1C   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CORO1C   OriGene Custom Protein Services for CORO1C  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CORO1C
     QIAGEN SeqTarget long-range PCR primers for resequencing CORO1C
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CORO1C
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CORO1C
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CORO1C
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CORO1C
     GenScript Custom Purified and Recombinant Proteins Services for CORO1C GenScript cDNA clones with any tag delivered in your preferred vector for CORO1C
     GenScript Custom Assay Services for CORO1C GenScript Custom Superior Antibodies Services for CORO1C
     GenScript Custom overexpressing Cell Line Services for CORO1C CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CORO1C promoter
     Search Chromatin IP Primers for CORO1C
     RT2 qPCR Primer Assay in human, mouse, rat CORO1C
     Search GNC Networks for CORO1C
     SABiosciences Custom PCR Arrays for CORO1C
     Search Tocris compounds for CORO1C (COR1C)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CORO1C antibodies
     CORO1C proteins
     CORO1C lysates
     Antibodies for CORO1C
     See all of Abcam's Antibodies, Kits and Proteins for CORO1C
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CORO1C
     Antibodies for CORO1C
     ELISAs for CORO1C
     CLIAs for CORO1C
     Search LifeMap BioReagents cell lines for CORO1C
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORO1C
     SwitchGear 3'UTR luciferase reporter plasmids for CORO1C
     SwitchGear Promoter luciferase reporter plasmids for CORO1C
     ThermoFisher Antibody for CORO1C
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CORO1C
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CORO1C
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CORO1C
    Customized:
     lentivirus for stable overexpression of CORO1C
     lentivirus expression plasmids for stable overexpression of CORO1C
     adenovirus for overexpression of CORO1C
     LSBio Antibodies in human, mouse, rat for CORO1C
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CORO1C gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4