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Aliases for CORO1C Gene

Aliases for CORO1C Gene

  • Coronin 1C 2 3
  • Coronin, Actin-Binding Protein, 1C 2 3
  • Coronin, Actin Binding Protein, 1C 3 5
  • Coronin-3 3 4
  • HCRNN4 3 4
  • CRNN4 4
  • CRN2 4

External Ids for CORO1C Gene

Previous GeneCards Identifiers for CORO1C Gene

  • GC12M108144
  • GC12M108919
  • GC12M108971
  • GC12M107541
  • GC12M109038
  • GC12M106103

Summaries for CORO1C Gene

Entrez Gene Summary for CORO1C Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

GeneCards Summary for CORO1C Gene

CORO1C (Coronin 1C) is a Protein Coding gene. Diseases associated with CORO1C include coronin-1a deficiency. GO annotations related to this gene include actin filament binding. An important paralog of this gene is CORO6.

UniProtKB/Swiss-Prot for CORO1C Gene

  • May be involved in cytokinesis, motility, and signal transduction.

  • Isoform 3: Involved in myogenic differentiation.

Gene Wiki entry for CORO1C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORO1C Gene

Genomics for CORO1C Gene

Regulatory Elements for CORO1C Gene

Promoters for CORO1C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CORO1C on UCSC Golden Path with GeneCards custom track

Genomic Location for CORO1C Gene

Chromosome:
12
Start:
108,645,109 bp from pter
End:
108,731,596 bp from pter
Size:
86,488 bases
Orientation:
Minus strand

Genomic View for CORO1C Gene

Genes around CORO1C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORO1C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORO1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO1C Gene

Proteins for CORO1C Gene

  • Protein details for CORO1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULV4-COR1C_HUMAN
    Recommended name:
    Coronin-1C
    Protein Accession:
    Q9ULV4
    Secondary Accessions:
    • A7MAP0
    • A7MAP1
    • B3KU12
    • Q9NSK5

    Protein attributes for CORO1C Gene

    Size:
    474 amino acids
    Molecular mass:
    53249 Da
    Quaternary structure:
    • Binds F-actin. Isoform 1 and isoform 2 appear as homotrimers, while isoform 3 seems to exist as monomers.
    SequenceCaution:
    • Sequence=CAB82406.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CORO1C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CORO1C Gene

Proteomics data for CORO1C Gene at MOPED

Post-translational modifications for CORO1C Gene

  • Ubiquitination at Lys 311 and Lys 391
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CORO1C Gene

Domains & Families for CORO1C Gene

Gene Families for CORO1C Gene

Protein Domains for CORO1C Gene

Suggested Antigen Peptide Sequences for CORO1C Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULV4

UniProtKB/Swiss-Prot:

COR1C_HUMAN :
  • The C-terminal coiled-coil domain is essential for cortical membrane localization and oligomerization.
  • Belongs to the WD repeat coronin family.
  • Contains 6 WD repeats.
Domain:
  • The C-terminal coiled-coil domain is essential for cortical membrane localization and oligomerization.
Family:
  • Belongs to the WD repeat coronin family.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with CORO1C: view

Function for CORO1C Gene

Molecular function for CORO1C Gene

UniProtKB/Swiss-Prot Function:
May be involved in cytokinesis, motility, and signal transduction.
UniProtKB/Swiss-Prot Function:
Isoform 3: Involved in myogenic differentiation.

Gene Ontology (GO) - Molecular Function for CORO1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051015 actin filament binding IMP 22364218
genes like me logo Genes that share ontologies with CORO1C: view
genes like me logo Genes that share phenotypes with CORO1C: view

Animal Models for CORO1C Gene

MGI Knock Outs for CORO1C:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CORO1C Gene

Localization for CORO1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for CORO1C Gene

Cell membrane. Cell projection, lamellipodium. Cytoplasm, cytoskeleton. Note=All isoforms localize in a diffuse and punctate pattern in the cytosol and are highly enriched in F-actin-rich areas. Isoform 3 colocalizes with the thin filaments of the sarcomere and with the postsynaptic area and the junctional sarcoplasm of motor end plates.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CORO1C Gene COMPARTMENTS Subcellular localization image for CORO1C gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 3
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for CORO1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005925 NOT colocalizes_with focal adhesion IDA 19913511
GO:0016600 flotillin complex IEA,ISS --
genes like me logo Genes that share ontologies with CORO1C: view

Pathways & Interactions for CORO1C Gene

SuperPathways for CORO1C Gene

No Data Available

SIGNOR curated interactions for CORO1C Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CORO1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001755 neural crest cell migration IMP 25074804
GO:0001933 negative regulation of protein phosphorylation IMP 19913511
GO:0006909 phagocytosis TAS 9778037
GO:0010633 negative regulation of epithelial cell migration IMP 19913511
GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation IMP 19913511
genes like me logo Genes that share ontologies with CORO1C: view

No data available for Pathways by source for CORO1C Gene

Drugs & Compounds for CORO1C Gene

No Compound Related Data Available

Transcripts for CORO1C Gene

Unigene Clusters for CORO1C Gene

Coronin, actin binding protein, 1C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CORO1C Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - -
SP5: -
SP6: - - - - -
SP7:

Relevant External Links for CORO1C Gene

GeneLoc Exon Structure for
CORO1C
ECgene alternative splicing isoforms for
CORO1C

Expression for CORO1C Gene

mRNA expression in normal human tissues for CORO1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CORO1C Gene

This gene is overexpressed in Platelet (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CORO1C Gene



SOURCE GeneReport for Unigene cluster for CORO1C Gene Hs.330384

mRNA Expression by UniProt/SwissProt for CORO1C Gene

Q9ULV4-COR1C_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with CORO1C: view

Protein tissue co-expression partners for CORO1C Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CORO1C Gene

Orthologs for CORO1C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CORO1C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CORO1C 36
  • 100 (a)
OneToOne
CORO1C 35
  • 99.43 (n)
  • 99.62 (a)
cow
(Bos Taurus)
Mammalia CORO1C 36
  • 89 (a)
OneToOne
CORO1C 35
  • 92.12 (n)
  • 98.73 (a)
dog
(Canis familiaris)
Mammalia CORO1C 35
  • 93.82 (n)
  • 99.17 (a)
CORO1C 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Coro1c 36
  • 97 (a)
OneToOne
Coro1c 16
Coro1c 35
  • 88.68 (n)
  • 97.47 (a)
oppossum
(Monodelphis domestica)
Mammalia CORO1C 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CORO1C 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Coro1c 35
  • 89.59 (n)
  • 98.31 (a)
chicken
(Gallus gallus)
Aves CORO1C 36
  • 95 (a)
OneToOne
CORO1C 35
  • 82.1 (n)
  • 94.71 (a)
lizard
(Anolis carolinensis)
Reptilia CORO1C 36
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.908 35
tropical clawed frog
(Silurana tropicalis)
Amphibia coro1c 35
  • 76.27 (n)
  • 85.38 (a)
MGC76199 35
zebrafish
(Danio rerio)
Actinopterygii coro1c 35
coro1cb 35
  • 76.15 (n)
  • 84.29 (a)
coro1ca 36
  • 81 (a)
OneToMany
coro1cb 36
  • 82 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005891 35
  • 58.56 (n)
  • 60.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta coro 37
  • 54 (a)
coro 35
  • 57.69 (n)
  • 56.68 (a)
worm
(Caenorhabditis elegans)
Secernentea cor-1 37
  • 51 (a)
cor-1 35
  • 55.85 (n)
  • 52.62 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER114W 35
  • 48.7 (n)
  • 42.49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRN1 38
CRN1 35
  • 49.83 (n)
  • 43.01 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D02530g 35
  • 48.94 (n)
  • 41.79 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00202 35
  • 51.64 (n)
  • 43.77 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes crn1 35
  • 47.54 (n)
  • 41.95 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.313 36
  • 42 (a)
OneToMany
Species with no ortholog for CORO1C:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CORO1C Gene

ENSEMBL:
Gene Tree for CORO1C (if available)
TreeFam:
Gene Tree for CORO1C (if available)

Paralogs for CORO1C Gene

Paralogs for CORO1C Gene

Pseudogenes.org Pseudogenes for CORO1C Gene

genes like me logo Genes that share paralogs with CORO1C: view

Variants for CORO1C Gene

Sequence variations from dbSNP and Humsavar for CORO1C Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1079088 -- 108,667,755(-) TACTG(A/C)TGGAT intron-variant
rs1345421 -- 108,691,259(+) GCTCA(G/T)TCTTC intron-variant
rs1861638 -- 108,671,681(-) TGTCA(A/C)AGTCA intron-variant
rs1861639 -- 108,668,422(-) GAAAT(A/G)AAAAT intron-variant
rs1861640 -- 108,668,378(-) GCAGG(C/G)AGGGC intron-variant

Variation tolerance for CORO1C Gene

Residual Variation Intolerance Score: 21.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CORO1C Gene

HapMap Linkage Disequilibrium report
CORO1C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CORO1C Gene

Disorders for CORO1C Gene

MalaCards: The human disease database

(1) MalaCards diseases for CORO1C Gene - From: DISEASES

Disorder Aliases PubMed IDs
coronin-1a deficiency
  • coronin 1a
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CORO1C

Genetic Association Database (GAD)
CORO1C
Human Genome Epidemiology (HuGE) Navigator
CORO1C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CORO1C
genes like me logo Genes that share disorders with CORO1C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CORO1C Gene

Publications for CORO1C Gene

  1. Isolation and chromosomal assignment of a novel human gene, CORO1C, homologous to coronin-like actin-binding proteins. (PMID: 10828594) Iizaka M. … Nakamura Y. (Cytogenet. Cell Genet. 2000) 3 4 23 67
  2. Coronin 1C negatively regulates cell-matrix adhesion and motility of intestinal epithelial cells. (PMID: 19913511) Samarin S.N. … Nusrat A. (Biochem. Biophys. Res. Commun. 2010) 3 23
  3. Structural and functional diversity of novel coronin 1C (CRN2) isoforms in muscle. (PMID: 19651142) Xavier C.P. … Clemen C.S. (J. Mol. Biol. 2009) 3 23
  4. Coronin 3 involvement in F-actin-dependent processes at the cell cortex. (PMID: 17274980) Rosentreter A. … Clemen C.S. (Exp. Cell Res. 2007) 3 23
  5. Oligomerization, F-actin interaction, and membrane association of the ubiquitous mammalian coronin 3 are mediated by its carboxyl terminus. (PMID: 12377779) Spoerl Z. … Hasse A. (J. Biol. Chem. 2002) 3 23

Products for CORO1C Gene

Sources for CORO1C Gene

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