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Aliases for CORO1C Gene

Aliases for CORO1C Gene

  • Coronin, Actin Binding Protein, 1C 2 3
  • Coronin, Actin-Binding Protein, 1C 2 3
  • Coronin-3 3 4
  • HCRNN4 3 4
  • Coronin 1C 3
  • Coronin-1C 3
  • CRNN4 4
  • CRN2 4

External Ids for CORO1C Gene

Previous GeneCards Identifiers for CORO1C Gene

  • GC12M108144
  • GC12M108919
  • GC12M108971
  • GC12M107541
  • GC12M109038
  • GC12M106103

Summaries for CORO1C Gene

Entrez Gene Summary for CORO1C Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

GeneCards Summary for CORO1C Gene

CORO1C (Coronin, Actin Binding Protein, 1C) is a Protein Coding gene. Diseases associated with CORO1C include coronin-1a deficiency. GO annotations related to this gene include actin filament binding. An important paralog of this gene is CORO6.

UniProtKB/Swiss-Prot for CORO1C Gene

  • May be involved in cytokinesis, motility, and signal transduction.

  • Isoform 3: Involved in myogenic differentiation

Gene Wiki entry for CORO1C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORO1C Gene

Genomics for CORO1C Gene

Regulatory Elements for CORO1C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CORO1C Gene

108,645,109 bp from pter
108,731,596 bp from pter
86,488 bases
Minus strand

Genomic View for CORO1C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CORO1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO1C Gene

Proteins for CORO1C Gene

  • Protein details for CORO1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A7MAP0
    • A7MAP1
    • B3KU12
    • Q9NSK5

    Protein attributes for CORO1C Gene

    474 amino acids
    Molecular mass:
    53249 Da
    Quaternary structure:
    • Binds F-actin. Isoform 1 and isoform 2 appear as homotrimers, while isoform 3 seems to exist as monomers.
    • Sequence=CAB82406.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CORO1C Gene


neXtProt entry for CORO1C Gene

Proteomics data for CORO1C Gene at MOPED

Post-translational modifications for CORO1C Gene

  • Ubiquitination at Lys311, Lys322, and Lys391
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CORO1C Gene

Domains for CORO1C Gene

Gene Families for CORO1C Gene

  • CORO :Coronins
  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for CORO1C Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9ULV4
  • The C-terminal coiled-coil domain is essential for cortical membrane localization and oligomerization
  • Belongs to the WD repeat coronin family.
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with CORO1C: view

Function for CORO1C Gene

Molecular function for CORO1C Gene

UniProtKB/Swiss-Prot Function:
May be involved in cytokinesis, motility, and signal transduction.
UniProtKB/Swiss-Prot Function:
Isoform 3: Involved in myogenic differentiation

Gene Ontology (GO) - Molecular Function for CORO1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25074804
GO:0051015 actin filament binding IMP 22364218
genes like me logo Genes that share ontologies with CORO1C: view

Phenotypes for CORO1C Gene

genes like me logo Genes that share phenotypes with CORO1C: view

Animal Model Products

miRNA for CORO1C Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CORO1C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CORO1C Gene

Localization for CORO1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for CORO1C Gene

Cell membrane. Cell projection, lamellipodium. Cytoplasm, cytoskeleton. Note=All isoforms localize in a diffuse and punctate pattern in the cytosol and are highly enriched in F-actin-rich areas. Isoform 3 colocalizes with the thin filaments of the sarcomere and with the postsynaptic area and the junctional sarcoplasm of motor end plates.

Subcellular locations from

Jensen Localization Image for CORO1C Gene COMPARTMENTS Subcellular localization image for CORO1C gene
Compartment Confidence
cytoskeleton 3
cytosol 3
mitochondrion 2
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CORO1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane --
GO:0005925 NOT colocalizes_with focal adhesion IDA 19913511
GO:0015629 actin cytoskeleton IDA 22364218
GO:0016328 lateral plasma membrane IDA 25074804
genes like me logo Genes that share ontologies with CORO1C: view

Pathways for CORO1C Gene

SuperPathways for CORO1C Gene

No Data Available

Gene Ontology (GO) - Biological Process for CORO1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001755 neural crest cell migration IMP 25074804
GO:0001932 regulation of protein phosphorylation IGI 19913511
GO:0001933 negative regulation of protein phosphorylation IMP 19913511
GO:0006909 phagocytosis TAS 9778037
GO:0007165 signal transduction TAS 9778037
genes like me logo Genes that share ontologies with CORO1C: view

No data available for Pathways by source for CORO1C Gene

Transcripts for CORO1C Gene

Unigene Clusters for CORO1C Gene

Coronin, actin binding protein, 1C:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CORO1C

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CORO1C Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - -
SP5: -
SP6: - - - - -

Relevant External Links for CORO1C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CORO1C Gene

mRNA expression in normal human tissues for CORO1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CORO1C Gene

This gene is overexpressed in Platelet (8.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CORO1C Gene

SOURCE GeneReport for Unigene cluster for CORO1C Gene Hs.330384

mRNA Expression by UniProt/SwissProt for CORO1C Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with CORO1C: view

Expression partners for CORO1C Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CORO1C Gene

Orthologs for CORO1C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CORO1C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CORO1C 35
  • 92.12 (n)
  • 98.73 (a)
  • 89 (a)
(Canis familiaris)
Mammalia CORO1C 35
  • 93.82 (n)
  • 99.17 (a)
  • 90 (a)
(Mus musculus)
Mammalia Coro1c 35
  • 88.68 (n)
  • 97.47 (a)
Coro1c 16
Coro1c 36
  • 97 (a)
(Pan troglodytes)
Mammalia CORO1C 35
  • 99.43 (n)
  • 99.62 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Coro1c 35
  • 89.59 (n)
  • 98.31 (a)
(Monodelphis domestica)
Mammalia CORO1C 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia CORO1C 36
  • 95 (a)
(Gallus gallus)
Aves CORO1C 35
  • 82.1 (n)
  • 94.71 (a)
  • 95 (a)
(Anolis carolinensis)
Reptilia CORO1C 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia coro1c 35
  • 76.27 (n)
  • 85.38 (a)
MGC76199 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.908 35
(Danio rerio)
Actinopterygii coro1c 35
coro1cb 35
  • 76.15 (n)
  • 84.29 (a)
coro1ca 36
  • 81 (a)
coro1cb 36
  • 82 (a)
fruit fly
(Drosophila melanogaster)
Insecta coro 37
  • 54 (a)
coro 35
  • 57.69 (n)
  • 56.68 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005891 35
  • 58.56 (n)
  • 60.93 (a)
(Caenorhabditis elegans)
Secernentea cor-1 37
  • 51 (a)
cor-1 35
  • 55.85 (n)
  • 52.62 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER114W 35
  • 48.7 (n)
  • 42.49 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D02530g 35
  • 48.94 (n)
  • 41.79 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRN1 35
  • 49.83 (n)
  • 43.01 (a)
CRN1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU00202 35
  • 51.64 (n)
  • 43.77 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes crn1 35
  • 47.54 (n)
  • 41.95 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.313 36
  • 42 (a)
Species with no ortholog for CORO1C:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CORO1C Gene

Gene Tree for CORO1C (if available)
Gene Tree for CORO1C (if available)

Paralogs for CORO1C Gene

Paralogs for CORO1C Gene Pseudogenes for CORO1C Gene

genes like me logo Genes that share paralogs with CORO1C: view

Variants for CORO1C Gene

Sequence variations from dbSNP and Humsavar for CORO1C Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs750133 -- 108,667,009(+) CACTC(A/G)TGGCT intron-variant
rs750134 -- 108,667,330(+) TGCAG(G/T)CTTGT intron-variant
rs750135 -- 108,666,963(+) AAACT(A/G)CCACT intron-variant
rs961355 -- 108,672,036(-) CCTGT(A/G)ATTCC intron-variant
rs1060665 -- 108,645,400(-) GAAAC(A/C)CCGTA utr-variant-3-prime

Relevant External Links for CORO1C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CORO1C Gene

Disorders for CORO1C Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CORO1C Gene in MalaCards »

(1) Diseases for CORO1C Gene including...

(1) University of Copenhagen DISEASES for CORO1C Gene

Relevant External Links for CORO1C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CORO1C: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for CORO1C Gene

Publications for CORO1C Gene

  1. Structural and functional diversity of novel coronin 1C (CRN2) isoforms in muscle. (PMID: 19651142) Xavier C.P. … Clemen C.S. (J. Mol. Biol. 2009) 3 4 23
  2. Isolation and chromosomal assignment of a novel human gene, CORO1C, homologous to coronin-like actin-binding proteins. (PMID: 10828594) Iizaka M. … Nakamura Y. (Cytogenet. Cell Genet. 2000) 3 4 23
  3. Oligomerization, F-actin interaction, and membrane association of the ubiquitous mammalian coronin 3 are mediated by its carboxyl terminus. (PMID: 12377779) Spoerl Z. … Hasse A. (J. Biol. Chem. 2002) 3 4 23
  4. Coronin 3 involvement in F-actin-dependent processes at the cell cortex. (PMID: 17274980) Rosentreter A. … Clemen C.S. (Exp. Cell Res. 2007) 3 23
  5. Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein. (PMID: 9778037) Okumura M. … Thomas M.L. (DNA Cell Biol. 1998) 2 3

Products for CORO1C Gene

Sources for CORO1C Gene

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