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Aliases for CORO1B Gene

Aliases for CORO1B Gene

  • Coronin, Actin Binding Protein, 1B 2 3
  • CORONIN-2 3 4
  • Coronin, Actin-Binding Protein, 1B 2
  • Coronin-1B 3

External Ids for CORO1B Gene

Summaries for CORO1B Gene

Entrez Gene Summary for CORO1B Gene

  • Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility (Cai et al., 2005 [PubMed 16027158]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CORO1B Gene

CORO1B (Coronin, Actin Binding Protein, 1B) is a Protein Coding gene. Diseases associated with CORO1B include coronin-1a deficiency. GO annotations related to this gene include actin filament binding. An important paralog of this gene is CORO6.

UniProtKB/Swiss-Prot for CORO1B Gene

  • Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORO1B Gene

Genomics for CORO1B Gene

Genomic Location for CORO1B Gene

Start:
67,435,510 bp from pter
End:
67,443,821 bp from pter
Size:
8,312 bases
Orientation:
Minus strand

Genomic View for CORO1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CORO1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO1B Gene

Regulatory Elements for CORO1B Gene

Proteins for CORO1B Gene

  • Protein details for CORO1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BR76-COR1B_HUMAN
    Recommended name:
    Coronin-1B
    Protein Accession:
    Q9BR76
    Secondary Accessions:
    • B2RD45

    Protein attributes for CORO1B Gene

    Size:
    489 amino acids
    Molecular mass:
    54235 Da
    Quaternary structure:
    • Forms homooligomers, but does not form complexes with the other coronins. Interacts with Arp2/3 complex components, including ACTR2, ARPC1B and ARPC2. Binds actin (By similarity).

neXtProt entry for CORO1B Gene

Proteomics data for CORO1B Gene at MOPED

Post-translational modifications for CORO1B Gene

  • Phosphorylation by PKC on Ser-2 regulates the interaction with the Arp2/3 complex and cell motility in fibroblasts. Phosphorylation does not seem to affect subcellular location.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys233 and Lys344

Other Protein References for CORO1B Gene

No data available for DME Specific Peptides for CORO1B Gene

Domains for CORO1B Gene

Gene Families for CORO1B Gene

HGNC:
  • WDR :WD repeat domain containing
  • CORO :Coronins

UniProtKB/Swiss-Prot:

COR1B_HUMAN
Family:
  • Belongs to the WD repeat coronin family.:
    • Q9BR76
Similarity:
  • Contains 6 WD repeats.:
    • Q9BR76
genes like me logo Genes that share domains with CORO1B: view

Function for CORO1B Gene

Molecular function for CORO1B Gene

UniProtKB/Swiss-Prot Function: Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity).

Gene Ontology (GO) - Molecular Function for CORO1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16027158
GO:0042802 identical protein binding IDA 16027158
GO:0051015 actin filament binding IMP 22364218
GO:0071933 Arp2/3 complex binding IPI 22619279
genes like me logo Genes that share ontologies with CORO1B: view

Phenotypes for CORO1B Gene

genes like me logo Genes that share phenotypes with CORO1B: view

Animal Models for CORO1B Gene

MGI Knock Outs for CORO1B:

miRNA for CORO1B Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CORO1B Gene

Localization for CORO1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CORO1B Gene

Cytoplasm, cytoskeleton. Note=Localized to the leading edge in fibroblasts, as well as weakly along actin stress fibers.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CORO1B Gene COMPARTMENTS Subcellular localization image for CORO1B gene
Compartment Confidence
cytoskeleton 5
cytosol 2
mitochondrion 2
endoplasmic reticulum 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CORO1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 16027158
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IDA 22619279
GO:0005884 actin filament IDA 18775315
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with CORO1B: view

Pathways for CORO1B Gene

SuperPathways for CORO1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for CORO1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016477 cell migration IDA 16027158
GO:0030036 actin cytoskeleton organization IDA 18775315
GO:0031529 ruffle organization IDA 16027158
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation IC 22619279
GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation IDA 17350576
genes like me logo Genes that share ontologies with CORO1B: view

No data available for Pathways by source for CORO1B Gene

Transcripts for CORO1B Gene

Unigene Clusters for CORO1B Gene

Coronin, actin binding protein, 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CORO1B Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12
SP1: - -
SP2: -
SP3: -
SP4:
SP5: -
SP6:

Relevant External Links for CORO1B Gene

GeneLoc Exon Structure for
CORO1B
ECgene alternative splicing isoforms for
CORO1B

Expression for CORO1B Gene

mRNA expression in normal human tissues for CORO1B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CORO1B Gene

SOURCE GeneReport for Unigene cluster for CORO1B Gene Hs.6191

genes like me logo Genes that share expressions with CORO1B: view

Orthologs for CORO1B Gene

This gene was present in the common ancestor of animals.

Orthologs for CORO1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CORO1B 36
  • 99.39 (n)
  • 99.59 (a)
CORO1B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CORO1B 36
  • 89.12 (n)
  • 91.99 (a)
CORO1B 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC476007 36
  • 89.71 (n)
  • 94.07 (a)
PPP1CA 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Coro1b 36
  • 87.19 (n)
  • 95.04 (a)
Coro1b 16
Coro1b 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CORO1B 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Coro1b 36
  • 86.57 (n)
  • 93.6 (a)
chicken
(Gallus gallus)
Aves gga-mir-6579-2 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CORO1B 37
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii coro1b 37
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta coro 38
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea cor-1 38
  • 52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.313 37
  • 41 (a)
OneToMany
Species with no ortholog for CORO1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CORO1B Gene

ENSEMBL:
Gene Tree for CORO1B (if available)
TreeFam:
Gene Tree for CORO1B (if available)

Paralogs for CORO1B Gene

Paralogs for CORO1B Gene

Selected SIMAP similar genes for CORO1B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CORO1B: view

Variants for CORO1B Gene

Sequence variations from dbSNP and Humsavar for CORO1B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1638555 -- 67,445,813(+) ggcac(A/G)tacca upstream-variant-2KB
rs1790744 -- 67,445,809(+) TACAG(G/T)CACGT upstream-variant-2KB
rs1808279 -- 67,444,098(+) AGGCT(C/T)ATACT upstream-variant-2KB
rs2286625 -- 67,441,699(+) CGTGG(A/C/G)GGGGG intron-variant
rs2302264 -- 67,439,955(+) AGGCC(A/G)ACCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CORO1B Gene

Variant ID Type Subtype PubMed ID
nsv897797 CNV Loss 21882294
nsv897801 CNV Loss 21882294
nsv897804 CNV Gain 21882294
dgv1193n71 CNV Loss 21882294
dgv1194n71 CNV Loss 21882294
nsv897811 CNV Loss 21882294
nsv521723 CNV Loss 19592680
nsv524096 CNV Loss 19592680
nsv468604 CNV Loss 19166990
nsv527056 CNV Loss 19592680

Relevant External Links for CORO1B Gene

HapMap Linkage Disequilibrium report
CORO1B

Disorders for CORO1B Gene

(1) MalaCards Diseases for CORO1B Gene

Search for CORO1B Gene in MalaCards »

(1) University of Copenhagen DISEASES for CORO1B Gene

genes like me logo Genes that share disorders with CORO1B: view

No data available for UniProtKB/Swiss-Prot for CORO1B Gene

Publications for CORO1B Gene

  1. Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein. (PMID: 9778037) Okumura M. … Thomas M.L. (DNA Cell Biol. 1998) 2 3 23
  2. Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility. (PMID: 16027158) Cai L. … Bear J.E. (J. Biol. Chem. 2005) 3 4 23
  3. Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge. (PMID: 17350576) Cai L. … Bear J.E. (Cell 2007) 3 23
  4. F-actin binding is essential for coronin 1B function in vivo. (PMID: 17456547) Cai L. … Bear J.E. (J. Cell. Sci. 2007) 3 23
  5. Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia. (PMID: 18775315) Cai L. … Bear J.E. (Cell 2008) 3 23

Products for CORO1B Gene

Sources for CORO1B Gene

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