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Aliases for CORO1B Gene

Aliases for CORO1B Gene

  • Coronin 1B 2 3 5
  • CORONIN-2 3 4
  • Coronin, Actin-Binding Protein, 1B 2
  • Coronin, Actin Binding Protein, 1B 3
  • Coronin-1B 3

External Ids for CORO1B Gene

Previous GeneCards Identifiers for CORO1B Gene

  • GC11P069657
  • GC11M068901
  • GC11M067455
  • GC11M066980
  • GC11M066962
  • GC11M067205
  • GC11M063533

Summaries for CORO1B Gene

Entrez Gene Summary for CORO1B Gene

  • Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell motility (Cai et al., 2005 [PubMed 16027158]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CORO1B Gene

CORO1B (Coronin 1B) is a Protein Coding gene. Diseases associated with CORO1B include Coronin-1A Deficiency. GO annotations related to this gene include identical protein binding and Arp2/3 complex binding. An important paralog of this gene is CORO1C.

UniProtKB/Swiss-Prot for CORO1B Gene

  • Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORO1B Gene

Genomics for CORO1B Gene

Regulatory Elements for CORO1B Gene

Enhancers for CORO1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G068325 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -885.9 -885856 7.5 FOXA2 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 SP5 MXD4 ZHX2 MRGPRF-AS1 MRGPRF ENSG00000261625 ENSG00000260808 C11orf24 LRP5 CORO1B IGHMBP2 FAM86C2P PPP6R3
GH11G066965 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +474.8 474769 6.8 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS DEK RAD9A EIF1AD CLCF1 ENSG00000258297 PC RBM14 RCE1 BRMS1 DPP3 ENSG00000245156
GH11G067350 1.8 FANTOM5 ENCODE dbSUPER 10.7 +89.1 89090 7.8 ZFP64 DMAP1 YBX1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 GLIS1 ENSG00000258297 RBM14 SSH3 RBM4B RCE1 ANKRD13D PTPRCAP RAD9A CORO1B RHOD
GH11G066636 1.4 ENCODE dbSUPER 13.3 +805.5 805486 3.8 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ACTN3 EIF1AD CORO1B RBM4B ENSG00000258297 RNU4-39P RBM14-RBM4 RBM14 ZDHHC24 ENSG00000255320
GH11G067238 1.4 ENCODE dbSUPER 13.3 +202.6 202582 5.7 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 CBX5 CORO1B ENSG00000258297 RAD9A ENSG00000255320 RPL37P2 PIR44214 PIR48284
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CORO1B on UCSC Golden Path with GeneCards custom track

Promoters for CORO1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000041108 221 1601 ARID4B SIN3A DMAP1 YY1 ETS1 TCF12 GLIS2 SP3 SP5 PPARG

Genomic Location for CORO1B Gene

Chromosome:
11
Start:
67,435,510 bp from pter
End:
67,443,821 bp from pter
Size:
8,312 bases
Orientation:
Minus strand

Genomic View for CORO1B Gene

Genes around CORO1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORO1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORO1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO1B Gene

Proteins for CORO1B Gene

  • Protein details for CORO1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BR76-COR1B_HUMAN
    Recommended name:
    Coronin-1B
    Protein Accession:
    Q9BR76
    Secondary Accessions:
    • B2RD45

    Protein attributes for CORO1B Gene

    Size:
    489 amino acids
    Molecular mass:
    54235 Da
    Quaternary structure:
    • Forms homooligomers, but does not form complexes with the other coronins. Interacts with Arp2/3 complex components, including ACTR2, ARPC1B and ARPC2. Binds actin (By similarity).

neXtProt entry for CORO1B Gene

Post-translational modifications for CORO1B Gene

  • Phosphorylation by PKC on Ser-2 regulates the interaction with the Arp2/3 complex and cell motility in fibroblasts. Phosphorylation does not seem to affect subcellular location.
  • Ubiquitination at Lys233 and isoforms=344
  • Modification sites at PhosphoSitePlus

Other Protein References for CORO1B Gene

No data available for DME Specific Peptides for CORO1B Gene

Domains & Families for CORO1B Gene

Gene Families for CORO1B Gene

Suggested Antigen Peptide Sequences for CORO1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BR76

UniProtKB/Swiss-Prot:

COR1B_HUMAN :
  • Belongs to the WD repeat coronin family.
Family:
  • Belongs to the WD repeat coronin family.
genes like me logo Genes that share domains with CORO1B: view

Function for CORO1B Gene

Molecular function for CORO1B Gene

UniProtKB/Swiss-Prot Function:
Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity).

Gene Ontology (GO) - Molecular Function for CORO1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 16027158
GO:0042802 identical protein binding IDA 16027158
GO:0045296 cadherin binding IDA 25468996
GO:0051015 actin filament binding IMP 22364218
genes like me logo Genes that share ontologies with CORO1B: view
genes like me logo Genes that share phenotypes with CORO1B: view

Animal Models for CORO1B Gene

MGI Knock Outs for CORO1B:

Animal Model Products

CRISPR Products

miRNA for CORO1B Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CORO1B Gene

Localization for CORO1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CORO1B Gene

Cytoplasm, cytoskeleton. Note=Localized to the leading edge in fibroblasts, as well as weakly along actin stress fibers.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CORO1B gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
cytosol 5
mitochondrion 2
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CORO1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 16027158
GO:0005737 cytoplasm IDA,IEA 23667561
GO:0005829 cytosol IDA 22619279
GO:0005856 cytoskeleton IEA --
GO:0005884 actin filament IDA 18775315
genes like me logo Genes that share ontologies with CORO1B: view

Pathways & Interactions for CORO1B Gene

SuperPathways for CORO1B Gene

No Data Available

SIGNOR curated interactions for CORO1B Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CORO1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016477 cell migration IDA 16027158
GO:0030036 actin cytoskeleton organization IDA 18775315
GO:0031529 ruffle organization IDA 16027158
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation IC 22619279
GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation IDA 17350576
genes like me logo Genes that share ontologies with CORO1B: view

No data available for Pathways by source for CORO1B Gene

Drugs & Compounds for CORO1B Gene

No Compound Related Data Available

Transcripts for CORO1B Gene

Unigene Clusters for CORO1B Gene

Coronin, actin binding protein, 1B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CORO1B Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12
SP1: - -
SP2: -
SP3: -
SP4:
SP5: -
SP6:

Relevant External Links for CORO1B Gene

GeneLoc Exon Structure for
CORO1B
ECgene alternative splicing isoforms for
CORO1B

Expression for CORO1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CORO1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CORO1B Gene



Protein tissue co-expression partners for CORO1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CORO1B Gene:

CORO1B

SOURCE GeneReport for Unigene cluster for CORO1B Gene:

Hs.6191

Evidence on tissue expression from TISSUES for CORO1B Gene

  • Nervous system(4.8)
  • Liver(4.2)
  • Intestine(2.8)
  • Lung(2.7)
  • Stomach(2)
genes like me logo Genes that share expression patterns with CORO1B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CORO1B Gene

Orthologs for CORO1B Gene

This gene was present in the common ancestor of animals.

Orthologs for CORO1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CORO1B 34 35
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia PPP1CA 35
  • 94 (a)
OneToOne
LOC476007 34
  • 89.71 (n)
cow
(Bos Taurus)
Mammalia CORO1B 34 35
  • 89.12 (n)
mouse
(Mus musculus)
Mammalia Coro1b 34 16 35
  • 87.19 (n)
rat
(Rattus norvegicus)
Mammalia Coro1b 34
  • 86.57 (n)
oppossum
(Monodelphis domestica)
Mammalia CORO1B 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-6579-2 35
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CORO1B 35
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii coro1b 35
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta coro 36
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea cor-1 36
  • 52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.313 35
  • 41 (a)
OneToMany
Species where no ortholog for CORO1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CORO1B Gene

ENSEMBL:
Gene Tree for CORO1B (if available)
TreeFam:
Gene Tree for CORO1B (if available)

Paralogs for CORO1B Gene

Paralogs for CORO1B Gene

(9) SIMAP similar genes for CORO1B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CORO1B: view

Variants for CORO1B Gene

Sequence variations from dbSNP and Humsavar for CORO1B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs756117196 A colorectal cancer sample 67,438,784(+) CAACA(C/T)GTTGC upstream-variant-2KB, reference, missense
rs1000694334 -- 67,444,556(+) AGTCT(C/T)GCTCT upstream-variant-2KB
rs1001235173 -- 67,438,919(+) TGTGT(C/T)GGGGT upstream-variant-2KB, reference, missense
rs1001436161 -- 67,437,788(+) AGACC(C/T)TCCCC intron-variant, upstream-variant-2KB
rs1001817619 -- 67,444,917(+) TCTTA(C/T)TACAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CORO1B Gene

Variant ID Type Subtype PubMed ID
dgv1977n54 CNV loss 21841781
dgv52n111 CNV deletion 26073780
nsv468604 CNV loss 19166990
nsv521723 CNV loss 19592680
nsv524096 CNV loss 19592680
nsv527056 CNV loss 19592680

Variation tolerance for CORO1B Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CORO1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CORO1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CORO1B Gene

Disorders for CORO1B Gene

MalaCards: The human disease database

(1) MalaCards diseases for CORO1B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
coronin-1a deficiency
  • coronin 1a
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CORO1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CORO1B
genes like me logo Genes that share disorders with CORO1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CORO1B Gene

Publications for CORO1B Gene

  1. Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility. (PMID: 16027158) Cai L. … Bear J.E. (J. Biol. Chem. 2005) 3 4 22 64
  2. Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein. (PMID: 9778037) Okumura M. … Thomas M.L. (DNA Cell Biol. 1998) 2 3 22 64
  3. Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia. (PMID: 18775315) Cai L. … Bear J.E. (Cell 2008) 3 22 64
  4. Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge. (PMID: 17350576) Cai L. … Bear J.E. (Cell 2007) 3 22 64
  5. F-actin binding is essential for coronin 1B function in vivo. (PMID: 17456547) Cai L. … Bear J.E. (J. Cell. Sci. 2007) 3 22 64

Products for CORO1B Gene

Sources for CORO1B Gene

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