CORO1B Gene
protein-coding GIFtS: 50
GCID: GC11M067205
|
|
coronin, actin binding protein, 1B(Previous names: coronin, actin-binding protein, 1B )
| |
Aliases
for CORO1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coronin, Actin Binding Protein, 1B1 2 | | Coronin, Actin-Binding Protein, 1B1 | | Coronin-23 | | CORONIN-22 | | Coronin-1B1 | | Coronin-23 |
Export aliases for CORO1B gene to outside databasesPrevious GC identifers: GC11P069657 GC11M068901 GC11M067455 GC11M066980 GC11M066962 GC11M063533 |
Summaries
for CORO1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CORO1B:
Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cellmotility (Cai et al., 2005 (PubMed 16027158)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: COR1B_HUMAN, Q9BR76Function: Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signaltransduction (By similarity)
|
Genomic Views
for CORO1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CORO1B gene promoter:
E2F-3a E2F-4 E2F E2F-1 Bach2 E2F-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CORO1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CORO1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.2 Ensembl cytogenetic band: 11q13.2 HGNC cytogenetic band: 11q13.1CORO1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M067205: view genomic region
(about GC identifiers)
Start:
|
67,205,518 bp from pter |
End:
|
67,211,292 bp from pter |
Size:
|
5,775 bases |
Orientation:
|
minus strand |
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Proteins
for CORO1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: COR1B_HUMAN, Q9BR76 (See
protein sequence)Recommended Name: Coronin-1B Size: 489 amino acids; 54235 Da
Subunit: Forms homooligomers, but does not form complexes with the other coronins. Interacts with Arp2/3 complexcomponents, including ACTR2, ARPC1B and ARPC2. Binds actin (By similarity)
Subcellular location: Cytoplasm, cytoskeleton. Note=Localized to the leading edge in fibroblasts, as well as weaklyalong actin stress fibers
Secondary accessions: B2RD45Explore the universe of human proteins at neXtProt for CORO1B: NX_Q9BR76
Post-translational modifications:
Phosphorylation by PKC on Ser-2 regulates the interaction with the Arp2/3 complex and cell motility in fibroblasts.Phosphorylation does not seem to affect subcellular location1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BR76
CORO1B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001018080.1 NP_065174.1
ENSEMBL proteins: ENSP00000340211 ENSP00000445330 ENSP00000416006 ENSP00000438056 ENSP00000377471
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
CORO1B for ontologies About GeneDecksing
CORO1B Antibody Products:
Assay Products for CORO1B: |
Protein
Domains /
Families
for CORO1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CORO1B for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9BR76ProtoNet protein and cluster: Q9BR76 UniProtKB/Swiss-Prot: COR1B_HUMAN, Q9BR76Similarity: Belongs to the WD repeat coronin familySimilarity: Contains 5 WD repeats |
Function
for CORO1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: COR1B_HUMAN, Q9BR76Function: Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signaltransduction (By similarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CORO1B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORO1B |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
CORO1B for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for CORO1B:
Animal Models:
Mouse knock-out Coro1btm1.1Nfoe for CORO1B
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Coro1b):
CORO1B for phenotypes About GeneDecksing
|
Pathways & Interactions
for CORO1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CORO1B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/11 Interacting proteins for CORO1B (Q9BR761, 2, 3 ENSP000003402114) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030036 | actin cytoskeleton organization |
IBA | -- |
CORO1B for ontologies About GeneDecksing
|
Drugs & Compounds
for CORO1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CORO1B
Search CenterWatch for drugs/clinical trials and news about CORO1B / COR1B
|
Transcripts
for CORO1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CORO1B gene (2 alternative transcripts): NM_001018070.2 NM_020441.2 Unigene Cluster for CORO1B: Coronin, actin binding protein, 1B Hs.6191 [show with all ESTs]Unigene Representative Sequence: NM_0010180709 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000341356(uc001olk.1 uc009yrt.1) ENST00000537042 ENST00000539724
ENST00000539970 ENST00000453768(uc010rps.1) ENST00000545016(uc009yrv.1)
ENST00000545736 ENST00000537010 ENST00000393893(uc001oll.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CORO1B (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CORO1B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CORO1B (NM_001018070) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CORO1B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CORO1B |
Additional cDNA sequence: AK000860.1 AK295782.1 AK315399.1 AL162072.1 BC006449.1 16 DOTS entries: DT.85105655 DT.91858694 DT.100883104 DT.100806074 DT.100710090 DT.97797305 DT.100831895 DT.100829736 DT.120735433 DT.100883094 DT.100883098 DT.95167986 DT.95167975 DT.100659547 DT.95167981 DT.95351542 24/629 AceView cDNA sequences (see all 629): BU622900 BQ056672 BX401220 CA488471 CR604867 BQ054123 CA489789 BQ954286 BM849949 CR615750 BQ961789 BC006449 CR589992 BM820040 AW956167 BM678823 BI518585 BQ447554 BM922676 AW206557 AA359974 AI383490 BI768388 BX443968
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CORO1B (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for CORO1B
|
Expression
for CORO1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CORO1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGAACGGGG
About this image
See CORO1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CORO1B
SOURCE GeneReport for Unigene cluster: Hs.6191
SABiosciences Custom PCR Arrays for CORO1B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CORO1B
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORO1B |
Orthologs
for CORO1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CORO1B gene from 4/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
CORO1B6-- |
-- |
80(a)29(a) |
1 ↔ 1possible ortholog |
1(93322652-93348108) GL344890.1(1981-18509) |
zebrafish
(Danio rerio) |
Actinopterygii |
coro1b6 |
coronin, actin binding protein, 1B |
60(a) |
possible ortholog |
7(19832691-19870773) |
fruit fly
(Drosophila melanogaster) |
Insecta |
coro3 |
actin binding |
54(a) |
|
42D4 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
cor-13 |
Coronin (beta transducin) |
52(a) |
|
III(10320798-10326235) -- |
ENSEMBL Gene Tree for CORO1B (if available)
TreeFam Gene Tree for CORO1B (if available) |
Paralogs
for CORO1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CORO1B gene
- CORO62 CORO1A2 CORO72 CORO1C2 CORO2A2 CORO2B2
9 SIMAP similar genes for CORO1B using alignment to 4 protein entries: COR1B_HUMAN (see all proteins):DKFZp762I166 CORO1C CORO1A CORO6 CORO2B CORO2A
CORO7 POC1B CORO7-PAM16
CORO1B for paralogs About GeneDecksing
|
Genomic Variants
for CORO1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CORO1B (67205518 - 67211292 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CORO1B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CORO1B |
|
Disorders
/ Diseases
for CORO1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CORO1B for disorders About GeneDecksing
OMIM gene information: 609849
OMIM disorders: --
1  disease for CORO1B: About MalaCardsmalaria
1 disease from the University of Copenhagen DISEASES database for CORO1B:coronin-1A deficiency Export disorders for CORO1B gene to outside databases
|
Publications
for CORO1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CORO1B gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with CORO1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility. (PubMed id 16027158)1, 2, 9 Cai L.... Bear J.E. (2005)
- Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein. (PubMed id 9778037)1, 3, 9 Okumura M....Thomas M.L. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge. (PubMed id 17350576)1, 9 Cai L....Bear J.E. (2007)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Novel mechanism for negatively regulating Rho-kinase ( ROCK) signaling through Coronin1B protein in neuregulin 1 (NRG-1)-induced tumor cell motility. (PubMed id 22563075)1 Rana M.K. and Worthylake R.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for CORO1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CORO1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CORO1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CORO1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CORO1B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CORO1B gene:
Search GeneIP for patents involving CORO1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CORO1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CORO1B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CORO1B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CORO1B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CORO1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CORO1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CORO1B |
| |
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| | | | Search Tocris compounds for CORO1B |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CORO1B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORO1B |
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