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CORO1B Gene

protein-coding   GIFtS: 53
GCID: GC11M067205

Coronin, Actin Binding Protein, 1B

(Previous names: coronin, actin-binding protein, 1B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coronin, Actin Binding Protein, 1B1 2
Coronin, Actin-Binding Protein, 1B1
CORONIN-22
coronin-1B2
Coronin-23

External Ids:    HGNC: 22531   Entrez Gene: 571752   Ensembl: ENSG000001727257   OMIM: 6098495   UniProtKB: Q9BR763   

Export aliases for CORO1B gene to outside databases

Previous GC identifers: GC11P069657 GC11M068901 GC11M067455 GC11M066980 GC11M066962 GC11M063533


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CORO1B Gene:
Members of the coronin family, such as CORO1B, are WD repeat-containing actin-binding proteins that regulate cell
motility (Cai et al., 2005 (PubMed 16027158)).(supplied by OMIM, Mar 2008)

GeneCards Summary for CORO1B Gene:
CORO1B (coronin, actin binding protein, 1B) is a protein-coding gene. Diseases associated with CORO1B include coronin-1a deficiency, and brain cancer. GO annotations related to this gene include actin filament binding. An important paralog of this gene is CORO7-PAM16.

UniProtKB/Swiss-Prot: COR1B_HUMAN, Q9BR76
Function: Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and
signal transduction (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CORO1B gene promoter:
         E2F-3a   E2F-4   E2F   E2F-1   Bach2   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCORO1B promoter sequence
   Search Chromatin IP Primers for CORO1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CORO1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.2   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.1

CORO1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CORO1B gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M067205:  view genomic region     (about GC identifiers)

Start:
67,205,518 bp from pter      End:
67,211,292 bp from pter
Size:
5,775 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: COR1B_HUMAN, Q9BR76 (See protein sequence)
Recommended Name: Coronin-1B  
Size: 489 amino acids; 54235 Da
Subunit: Forms homooligomers, but does not form complexes with the other coronins. Interacts with Arp2/3 complex
components, including ACTR2, ARPC1B and ARPC2. Binds actin (By similarity)
Secondary accessions: B2RD45

Explore the universe of human proteins at neXtProt for CORO1B: NX_Q9BR76

Explore proteomics data for CORO1B at MOPED

Post-translational modifications: 

  • Phosphorylation by PKC on Ser-2 regulates the interaction with the Arp2/3 complex and cell motility in
    fibroblasts. Phosphorylation does not seem to affect subcellular location1
  • Ubiquitination2 at Lys233, Lys344
  • Modification sites at PhosphoSitePlus

  • See CORO1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001018080.1  NP_065174.1  

    ENSEMBL proteins: 
     ENSP00000340211   ENSP00000445330   ENSP00000416006   ENSP00000438056   ENSP00000377471  

    CORO1B Human Recombinant Protein Products:

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    Novus Biologicals CORO1B Protein
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    CORO1B Antibody Products:

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    Cloud-Clone Corp. CLIAs for CORO1B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing
    CORO: Coronins

    Selected InterPro protein domains (see all 8):
     IPR019775 WD40_repeat_CS
     IPR015049 DUF1900
     IPR027340 Coro1b
     IPR001680 WD40_repeat
     IPR015505 Coronin

    Graphical View of Domain Structure for InterPro Entry Q9BR76

    ProtoNet protein and cluster: Q9BR76

    UniProtKB/Swiss-Prot: COR1B_HUMAN, Q9BR76
    Similarity: Belongs to the WD repeat coronin family
    Similarity: Contains 5 WD repeats


    CORO1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COR1B_HUMAN, Q9BR76
    Function: Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and
    signal transduction (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16027158
    GO:0042802identical protein binding IDA16027158
    GO:0051015actin filament binding IDA17456547
    GO:0071933Arp2/3 complex binding IDA16027158
         
    CORO1B for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CORO1B:
     Decreased focal adhesion (FA)   Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Coro1b):
     hematopoietic system  immune system 

    CORO1B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Coro1btm1.1Nfoe for CORO1B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CORO1B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CORO1B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CORO1B

    miRNA
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    miRTarBase miRNAs that target CORO1B:
    hsa-mir-155-5p (MIRT020753), hsa-mir-106b-3p (MIRT038589), hsa-mir-760 (MIRT036781), hsa-mir-34a-5p (MIRT025452)

    Block miRNA regulation of human, mouse, rat CORO1B using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CORO1B:
    hsa-miR-3673 hsa-miR-206 hsa-miR-1 hsa-miR-613 hsa-miR-3647-3p
    SwitchGear 3'UTR luciferase reporter plasmidCORO1B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CORO1B
    Predesigned siRNA for gene silencing in human, mouse, rat CORO1B

    Gene Editing
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    OriGene ORF clones in mouse, rat for CORO1B
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    GenScript: all cDNA clones in your preferred vector (see all 2): CORO1B (NM_001018070)
    Sino Biological Human cDNA Clone for CORO1B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CORO1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CORO1B

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    Browse ESI BIO Cell Lines and PureStem Progenitors for CORO1B 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORO1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COR1B_HUMAN, Q9BR76: Cytoplasm, cytoskeleton. Note=Localized to the leading edge in fibroblasts, as well as
    weakly along actin stress fibers
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol2
    mitochondrion2
    endoplasmic reticulum1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IDA16027158
    GO:0005737cytoplasm IDA--
    GO:0005884actin filament IDA18775315
    GO:0015629actin cytoskeleton IBA--
    GO:0030027lamellipodium IDA--

    CORO1B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CORO1B
    Interactions:

        Search GeneGlobe Interaction Network for CORO1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CORO1B (Q9BR761, 2, 3 ENSP000003402114) via UniProtKB, MINT, STRING, and/or I2D (see all 80)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SSH1Q8WYL51, 3, ENSP000003157134EBI-351152,EBI-1222387 I2D: score=2 STRING: ENSP00000315713
    ENSG00000258947Q135093, ENSP000003202954I2D: score=1 STRING: ENSP00000320295
    ARPC2O151441, 3, ENSP000002956854EBI-351152,EBI-352356 I2D: score=3 STRING: ENSP00000295685
    TUBB3Q135093I2D: score=1 
    PRKCAP172523, ENSP000002843844I2D: score=1 STRING: ENSP00000284384
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016477cell migration IDA16027158
    GO:0030036actin cytoskeleton organization IBA--
    GO:0031529ruffle organization IDA16027158
    GO:0034316negative regulation of Arp2/3 complex-mediated actin nucleation IDA17350576
    GO:0035767endothelial cell chemotaxis IDA--

    CORO1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CORO1B (COR1B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CORO1B gene (2 alternative transcripts): 
    NM_001018070.2  NM_020441.2  

    Unigene Cluster for CORO1B:

    Coronin, actin binding protein, 1B
    Hs.6191  [show with all ESTs]
    Unigene Representative Sequence: NM_001018070
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341356(uc001olk.1 uc009yrt.1) ENST00000537042 ENST00000539724
    ENST00000539970 ENST00000453768(uc010rps.1) ENST00000545016(uc009yrv.1)
    ENST00000545736 ENST00000537010 ENST00000393893(uc001oll.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CORO1B using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CORO1B:
    hsa-miR-3673 hsa-miR-206 hsa-miR-1 hsa-miR-613 hsa-miR-3647-3p
    SwitchGear 3'UTR luciferase reporter plasmidCORO1B 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CORO1B
    Predesigned siRNA for gene silencing in human, mouse, rat CORO1B
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    Primer
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    OriGene qPCR primer pairs and template standards for CORO1B
    OriGene qSTAR qPCR primer pairs in human, mouse for CORO1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CORO1B
      QuantiTect SYBR Green Assays in human, mouse, rat CORO1B
      QuantiFast Probe-based Assays in human, mouse, rat CORO1B

    Additional mRNA sequence: 

    AK000860.1 AK295782.1 AK315399.1 AL162072.1 BC006449.1 

    16 DOTS entries:

    DT.85105655  DT.91858694  DT.100883104  DT.100806074  DT.100710090  DT.97797305  DT.100831895  DT.100829736 
    DT.120735433  DT.100883094  DT.100883098  DT.95167986  DT.95167975  DT.100659547  DT.95167981  DT.95351542 

    Selected AceView cDNA sequences (see all 629):

    BM554440 BM819968 BF983034 CR604673 BM769626 BI870906 BI836913 CR605530 
    BM849123 BG677165 BM848557 BE046417 CR612430 AW963667 BQ640755 BU857361 
    AL162072 BM919822 BM561333 CR626258 BM837967 BX281843 CR615962 BQ056412 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CORO1B (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12
    SP1:                                                        -                                               -         
    SP2:              -                                                                                                   
    SP3:              -                                                                                                   
    SP4:                                                                                                                  
    SP5:                                                                                -                                 


    ECgene alternative splicing isoforms for CORO1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CORO1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAACGGGG
    CORO1B Expression
    About this image

    CORO1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CORO1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.6191
        Custom PCR Arrays for CORO1B
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORO1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CORO1B gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Coro1b1 , 5 coronin, actin binding protein 1B1, 5 87.19(n)1
    95.04(a)1
      19 (3.85 cM)5
    237891  NM_011778.21  NP_035908.11 
     41486195 
    chicken
    (Gallus gallus)
    Aves gga-mir-6579-26
    gga-mir-6579-2
    84(a)
    1 ↔ 1
    5(507411-517159) ENSGALG00000026394
    lizard
    (Anolis carolinensis)
    Reptilia CORO1B6
    coronin, actin binding protein, 1B
    81(a)
    1 ↔ 1
    1(93322652-93355399)
    zebrafish
    (Danio rerio)
    Actinopterygii coro1b6
    coronin, actin binding protein, 1B
    62(a)
    1 ↔ 1
    7(19832691-19870773) ENSDARG00000008660


    ENSEMBL Gene Tree for CORO1B (if available)
    TreeFam Gene Tree for CORO1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CORO1B gene
    CORO7-PAM162  CORO1A2  CORO62  CORO72  CORO1C2  CORO2B2  CORO2A2  
    9 SIMAP similar genes for CORO1B using alignment to 4 protein entries:     COR1B_HUMAN (see all proteins):
    DKFZp762I166    CORO1C    CORO1A    CORO6    CORO2B    CORO2A
    CORO7    POC1B    CORO7-PAM16

    CORO1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CORO1B (see all 182)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358774
    A colorectal cancer sample4--see VAR_0358772 V M mis40--------
    rs578663821,2
    C--67207197(+) GTCACA/CACTGC 2 -- int14Minor allele frequency- C:0.06NA WA EA 360
    rs1442734201,2
    C--67207209(+) TGGCCC/TGCTTG 2 -- int10--------
    rs1995239511,2
    --67207237(+) TGAGCC/TGAGGG 2 -- int10--------
    rs1130316171,2
    C--67207255(+) GCCTCA/G/TCCTTT 2 -- spd11CSA 1
    rs1117526381,2
    C--67207256(+) CCTCAA/C/GCTTTC 2 -- spd11CSA 1
    rs1999827911,2
    C--67207277(+) CATGAC/TGATGG 4 I V mis10--------
    rs1123271981,2
    C--67207316(+) GAACCG/TGGGGA 2 -- spa10--------
    rs2020035751,2
    --67207317(+) AACCTA/GGGGAT 2 -- int10--------
    rs23022641,2
    C,F,A,H--67207426(+) AGGCCG/AACCCC 2 -- int126Minor allele frequency- A:0.35EA NS NA WA CSA 3602

    HapMap Linkage Disequilibrium report for CORO1B (67205518 - 67211292 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CORO1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv468604CNV Loss19166990
    nsv527056CNV Loss19592680
    nsv897797CNV Loss21882294
    nsv521723CNV Loss19592680
    nsv897811CNV Loss21882294
    dgv1194n71CNV Loss21882294
    nsv524096CNV Loss19592680
    dgv1193n71CNV Loss21882294
    nsv897801CNV Loss21882294
    nsv897804CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609849    OMIM disorders: --

    5 diseases for CORO1B:    
    About MalaCards
    coronin-1a deficiency    brain cancer    breast and colorectal cancer    coronary artery disease
    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for CORO1B:
    coronin-1A deficiency

    CORO1B for disorders           About GeneDecksing


    Export disorders for CORO1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CORO1B gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with CORO1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility. (PubMed id 16027158)1, 2, 9 Cai L.... Bear J.E. (J. Biol. Chem. 2005)
    2. Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein. (PubMed id 9778037)1, 3, 9 Okumura M....Thomas M.L. (DNA Cell Biol. 1998)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. F-actin binding is essential for coronin 1B function in vivo. (PubMed id 17456547)1, 9 Cai L....Bear J.E. (J. Cell. Sci. 2007)
    5. Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge. (PubMed id 17350576)1, 9 Cai L....Bear J.E. (Cell 2007)
    6. Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia. (PubMed id 18775315)1, 9 Cai L....Bear J.E. (Cell 2008)
    7. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    8. Coronin 1B regulates S1P-induced human lung endothelial cell chemotaxis: role of PLD2, protein kinase C and Rac1 signal transduction. (PubMed id 23667561)1 Usatyuk P.V....Natarajan V. (PLoS ONE 2013)
    9. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57175 HGNC: 2253 AceView: PTPRCAPandCORO1B Ensembl:ENSG00000172725 euGenes: HUgn57175
    ECgene: CORO1B H-InvDB: CORO1B

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CORO1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CORO1B gene:
    Search GeneIP for patents involving CORO1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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