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Aliases for CORO1A Gene

Aliases for CORO1A Gene

  • Coronin, Actin Binding Protein, 1A 2 3
  • TACO 3 4 6
  • Tryptophan Aspartate-Containing Coat Protein 3 4
  • Coronin-Like Protein P57 3 4
  • Coronin-Like Protein A 3 4
  • Clipin-A 3 4
  • CLIPINA 3 6
  • IMD8 3 6
  • Coronin, Actin-Binding Protein, 1A 2
  • Clabp TACO 2
  • Coronin-1A 3
  • Coronin-1 3
  • HCORO1 3
  • CLABP 3
  • CORO1 4
  • P57 3

External Ids for CORO1A Gene

Previous GeneCards Identifiers for CORO1A Gene

  • GC16M028961
  • GC16P030516
  • GC16P030193
  • GC16P030231
  • GC16P030103
  • GC16P027857

Summaries for CORO1A Gene

Entrez Gene Summary for CORO1A Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]

GeneCards Summary for CORO1A Gene

CORO1A (Coronin, Actin Binding Protein, 1A) is a Protein Coding gene. Diseases associated with CORO1A include immunodeficiency 8 and severe combined immunodeficiency due to coro1a deficiency. Among its related pathways are Tuberculosis and Phagosome. GO annotations related to this gene include protein homodimerization activity and actin filament binding. An important paralog of this gene is CORO6.

UniProtKB/Swiss-Prot for CORO1A Gene

  • May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.

Gene Wiki entry for CORO1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORO1A Gene

Genomics for CORO1A Gene

Regulatory Elements for CORO1A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CORO1A Gene

Start:
30,182,827 bp from pter
End:
30,189,076 bp from pter
Size:
6,250 bases
Orientation:
Plus strand

Genomic View for CORO1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CORO1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO1A Gene

Proteins for CORO1A Gene

  • Protein details for CORO1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31146-COR1A_HUMAN
    Recommended name:
    Coronin-1A
    Protein Accession:
    P31146
    Secondary Accessions:
    • B2RBL1
    • Q2YD73

    Protein attributes for CORO1A Gene

    Size:
    461 amino acids
    Molecular mass:
    51026 Da
    Quaternary structure:
    • Binds actin

neXtProt entry for CORO1A Gene

Proteomics data for CORO1A Gene at MOPED

Post-translational modifications for CORO1A Gene

  • phosphorylation at Thr-412 by PKC strongly down-regulates the association with actin.
  • Polyubiquitinated by RNF128 with Lys-48-linked chains, leading to proteasomal degradation.
  • Ubiquitination at Lys20, Lys66, Lys233, Lys313, Lys324, Lys331, Lys355, and Lys393
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CORO1A Gene

Domains for CORO1A Gene

Gene Families for CORO1A Gene

HGNC:
  • CORO :Coronins
  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for CORO1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31146

UniProtKB/Swiss-Prot:

COR1A_HUMAN :
  • P31146
Family:
  • Belongs to the WD repeat coronin family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with CORO1A: view

Function for CORO1A Gene

Molecular function for CORO1A Gene

UniProtKB/Swiss-Prot Function: May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.

Gene Ontology (GO) - Molecular Function for CORO1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IPI 23100250
GO:0003785 actin monomer binding IMP 23100250
GO:0005515 protein binding IPI 11094157
GO:0008022 protein C-terminus binding IPI 9365277
GO:0008092 cytoskeletal protein binding ISS --
genes like me logo Genes that share ontologies with CORO1A: view

Phenotypes for CORO1A Gene

genes like me logo Genes that share phenotypes with CORO1A: view

Animal Models for CORO1A Gene

MGI Knock Outs for CORO1A:

Animal Model Products

CRISPR Products

miRNA for CORO1A Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CORO1A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CORO1A Gene

Localization for CORO1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CORO1A Gene

Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle, phagosome membrane. Note=In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CORO1A Gene COMPARTMENTS Subcellular localization image for CORO1A gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 2
mitochondrion 2
endosome 1
lysosome 1
nucleus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CORO1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 24760828
GO:0001891 phagocytic cup IDA 17442961
GO:0005634 NOT nucleus IDA 17341475
GO:0005737 cytoplasm IDA 17341475
GO:0005769 early endosome IEA --
genes like me logo Genes that share ontologies with CORO1A: view

Pathways for CORO1A Gene

SuperPathways for CORO1A Gene

Superpath Contained pathways
1 Tuberculosis
2 Phagosome
genes like me logo Genes that share pathways with CORO1A: view

Pathways by source for CORO1A Gene

2 KEGG pathways for CORO1A Gene

Gene Ontology (GO) - Biological Process for CORO1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001771 NOT immunological synapse formation IMP 24760828
GO:0001845 phagolysosome assembly IMP 12132654
GO:0006816 calcium ion transport IEA --
GO:0006909 phagocytosis IMP 17442961
GO:0006928 movement of cell or subcellular component NAS 17341475
genes like me logo Genes that share ontologies with CORO1A: view

Compounds for CORO1A Gene

(2) Novoseek inferred chemical compound relationships for CORO1A Gene

Compound -log(P) Hits PubMed IDs
leucine 37.8 5
nadph 28.1 1
genes like me logo Genes that share compounds with CORO1A: view

Transcripts for CORO1A Gene

Unigene Clusters for CORO1A Gene

Coronin, actin binding protein, 1A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CORO1A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CORO1A Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^
SP1: - - - - - - -
SP2: -
SP3: -
SP4: - - -
SP5: -
SP6: - - - - - - - - - -
SP7: - -
SP8: - - - - -
SP9: - - - - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - -
SP12:
SP13: -
SP14:

ExUns: 13 ^ 14a · 14b ^ 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for CORO1A Gene

GeneLoc Exon Structure for
CORO1A
ECgene alternative splicing isoforms for
CORO1A

Expression for CORO1A Gene

mRNA expression in normal human tissues for CORO1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CORO1A Gene

This gene is overexpressed in Whole Blood (25.8) and Spleen (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CORO1A Gene

SOURCE GeneReport for Unigene cluster for CORO1A Gene Hs.415067

mRNA Expression by UniProt/SwissProt for CORO1A Gene

P31146-COR1A_HUMAN
Tissue specificity: Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut
genes like me logo Genes that share expressions with CORO1A: view

In Situ Assay Products

Orthologs for CORO1A Gene

This gene was present in the common ancestor of animals.

Orthologs for CORO1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CORO1A 35
  • 99.86 (n)
  • 99.78 (a)
CORO1A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CORO1A 35
  • 92.12 (n)
  • 95.44 (a)
CORO1A 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CORO1A 35
  • 92.26 (n)
  • 97.18 (a)
CORO1A 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Coro1a 35
  • 89.08 (n)
  • 94.58 (a)
Coro1a 16
Coro1a 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CORO1A 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CORO1A 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Coro1a 35
  • 88.65 (n)
  • 93.93 (a)
lizard
(Anolis carolinensis)
Reptilia CORO1A 36
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC69077 35
tropical clawed frog
(Silurana tropicalis)
Amphibia coro2b 35
  • 72.48 (n)
  • 73.51 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6309 35
zebrafish
(Danio rerio)
Actinopterygii coro1a 35
  • 69.4 (n)
  • 69.25 (a)
coro1a 36
  • 69 (a)
OneToOne
zgc63766 35
fruit fly
(Drosophila melanogaster)
Insecta coro 37
  • 57 (a)
worm
(Caenorhabditis elegans)
Secernentea cor-1 37
  • 51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.313 36
  • 40 (a)
OneToMany
Species with no ortholog for CORO1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CORO1A Gene

ENSEMBL:
Gene Tree for CORO1A (if available)
TreeFam:
Gene Tree for CORO1A (if available)

Paralogs for CORO1A Gene

Paralogs for CORO1A Gene

Pseudogenes.org Pseudogenes for CORO1A Gene

genes like me logo Genes that share paralogs with CORO1A: view

Variants for CORO1A Gene

Sequence variations from dbSNP and Humsavar for CORO1A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs930392 -- 30,183,519(-) CGGGC(C/T)CCCGC utr-variant-5-prime
rs1132812 -- 30,186,830(+) ATCCC(A/G)GATGG reference, synonymous-codon
rs1804109 - 30,188,539(+) GCGCA(A/G)GAGGG missense, reference
rs1866393 -- 30,183,779(+) GTggg(C/G)cggcg intron-variant
rs7197202 -- 30,183,920(+) GCGCT(A/C)TGCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CORO1A Gene

Variant ID Type Subtype PubMed ID
nsv905720 CNV Loss 21882294
dgv846e1 CNV Complex 17122850
nsv905721 CNV Loss 21882294
dgv847e1 CNV Complex 17122850
nsv905722 CNV Loss 21882294
nsv905723 CNV Loss 21882294
nsv9431 CNV Gain+Loss 18304495
esv22245 CNV Gain 19812545
nsv821543 CNV Duplication 20802225

Relevant External Links for CORO1A Gene

HapMap Linkage Disequilibrium report
CORO1A
Human Gene Mutation Database (HGMD)
CORO1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CORO1A Gene

Disorders for CORO1A Gene

(1) OMIM Diseases for CORO1A Gene (605000)

UniProtKB/Swiss-Prot

COR1A_HUMAN
  • Immunodeficiency 8 (IMD8) [MIM:615401]: A disease of the immune system leading to recurrent infections, and characterized by CD4+ T-cells lymphopenia. Patients can develop B-cell lymphoproliferation associated with Epstein-Barr virus infection. {ECO:0000269 PubMed:19097825, ECO:0000269 PubMed:23522482}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with CORO1A: view

Publications for CORO1A Gene

  1. Molecular cloning of a novel actin-binding protein, p57, with a WD repeat and a leucine zipper motif. (PMID: 7758584) Suzuki K. … Toyoshima S. (FEBS Lett. 1995) 3 4 23
  2. Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein. (PMID: 9778037) Okumura M. … Thomas M.L. (DNA Cell Biol. 1998) 2 3 23
  3. Actin-binding proteins coronin-1a and IBA-1 are effective microglial markers for immunohistochemistry. (PMID: 17341475) Ahmed Z. … Dickson D.W. (J. Histochem. Cytochem. 2007) 3 23
  4. Coronin function is required for chemotaxis and phagocytosis in human neutrophils. (PMID: 17442961) Yan M. … Trimble W.S. (J. Immunol. 2007) 3 23
  5. Two regions responsible for the actin binding of p57, a mammalian coronin family actin-binding protein. (PMID: 12673016) Oku T. … Toyoshima S. (Biol. Pharm. Bull. 2003) 3 23

Products for CORO1A Gene

Sources for CORO1A Gene

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