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Aliases for CORO1A Gene

Aliases for CORO1A Gene

  • Coronin 1A 2 3 5
  • Tryptophan Aspartate-Containing Coat Protein 3 4
  • Coronin-Like Protein P57 3 4
  • Coronin-Like Protein A 3 4
  • Clipin-A 3 4
  • TACO 3 4
  • Coronin, Actin-Binding Protein, 1A 2
  • Coronin, Actin Binding Protein, 1A 3
  • Clabp TACO 2
  • Coronin-1A 3
  • Coronin-1 3
  • CLIPINA 3
  • HCORO1 3
  • CLABP 3
  • CORO1 4
  • IMD8 3
  • P57 3

External Ids for CORO1A Gene

Previous GeneCards Identifiers for CORO1A Gene

  • GC16M028961
  • GC16P030516
  • GC16P030193
  • GC16P030231
  • GC16P030103
  • GC16P027857

Summaries for CORO1A Gene

Entrez Gene Summary for CORO1A Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]

GeneCards Summary for CORO1A Gene

CORO1A (Coronin 1A) is a Protein Coding gene. Diseases associated with CORO1A include Immunodeficiency 8 and Coronin-1A Deficiency. Among its related pathways are Tuberculosis and Phagosome. GO annotations related to this gene include poly(A) RNA binding and identical protein binding. An important paralog of this gene is CORO6.

UniProtKB/Swiss-Prot for CORO1A Gene

  • May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.

Gene Wiki entry for CORO1A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORO1A Gene

Genomics for CORO1A Gene

Regulatory Elements for CORO1A Gene

Enhancers for CORO1A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G030119 1.1 ENCODE 12.6 -60.7 -60657 5.8 FOXA2 PKNOX1 MLX CREB3L1 SIN3A ARID4B FEZF1 DMAP1 ZNF2 YY1 MAPK3 YPEL3 CORO1A BOLA2B SLX1A-SULT1A3 SLX1A CD2BP2 GC16P030116
GH16G030112 1.1 ENCODE 12.3 -68.0 -67980 5.5 HDGF CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 TBX6 MAPK3 CORO1A SLX1A-SULT1A3 SLX1A BOLA2B CD2BP2 DOC2A YPEL3 GC16P030116
GH16G030566 2.1 FANTOM5 Ensembl ENCODE dbSUPER 3.6 +387.0 387048 6.0 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 ENSG00000260267 ZNF747 NPIPB13 ENSG00000260304 SMG1P2 BCL7C ZNF764 ZNF785 CDIPT PRR14
GH16G029742 1.5 FANTOM5 ENCODE dbSUPER 3 -437.7 -437695 5.4 HDGF YY1 ZNF121 CBX5 ELK1 ZNF207 JUNB REST TBX21 PPARG RN7SKP127 C16orf54 TBX6 YPEL3 MYLPF CORO1A PPP4C ENSG00000260719
GH16G029700 1.5 FANTOM5 Ensembl ENCODE 2.4 -480.9 -480903 3.6 SIN3A ARID4B ZBTB7B CBX5 ZNF143 DEK REST TBX21 ZNF592 MIER3 NPIPB13 C16orf54 MVP DOC2A ENSG00000198106 NPIPB11 ENSG00000260853 ENSG00000235560 RN7SKP127 CORO1A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CORO1A on UCSC Golden Path with GeneCards custom track

Promoters for CORO1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085166 1173 2401 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 GLIS2 ZNF263 SP3 SP5

Genomic Location for CORO1A Gene

Chromosome:
16
Start:
30,182,827 bp from pter
End:
30,189,076 bp from pter
Size:
6,250 bases
Orientation:
Plus strand

Genomic View for CORO1A Gene

Genes around CORO1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORO1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORO1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO1A Gene

Proteins for CORO1A Gene

  • Protein details for CORO1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31146-COR1A_HUMAN
    Recommended name:
    Coronin-1A
    Protein Accession:
    P31146
    Secondary Accessions:
    • B2RBL1
    • Q2YD73

    Protein attributes for CORO1A Gene

    Size:
    461 amino acids
    Molecular mass:
    51026 Da
    Quaternary structure:
    • Binds actin.

neXtProt entry for CORO1A Gene

Post-translational modifications for CORO1A Gene

  • phosphorylation at Thr-412 by PKC strongly down-regulates the association with actin.
  • Polyubiquitinated by RNF128 with Lys-48-linked chains, leading to proteasomal degradation.
  • Ubiquitination at isoforms=20, isoforms=66, isoforms=233, isoforms=313, isoforms=331, isoforms=355, and isoforms=393
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for CORO1A

Assay Products

  • Cloud-Clone Corp Assay Kits for CORO1A

No data available for DME Specific Peptides for CORO1A Gene

Domains & Families for CORO1A Gene

Gene Families for CORO1A Gene

Suggested Antigen Peptide Sequences for CORO1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31146

UniProtKB/Swiss-Prot:

COR1A_HUMAN :
  • Belongs to the WD repeat coronin family.
Family:
  • Belongs to the WD repeat coronin family.
genes like me logo Genes that share domains with CORO1A: view

Function for CORO1A Gene

Molecular function for CORO1A Gene

UniProtKB/Swiss-Prot Function:
May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.

Gene Ontology (GO) - Molecular Function for CORO1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003779 actin binding IPI 23100250
GO:0003785 actin monomer binding IMP 23100250
GO:0005515 protein binding IPI 11094157
GO:0008022 protein C-terminus binding IPI 9365277
genes like me logo Genes that share ontologies with CORO1A: view
genes like me logo Genes that share phenotypes with CORO1A: view

Human Phenotype Ontology for CORO1A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CORO1A Gene

MGI Knock Outs for CORO1A:

Animal Model Products

miRNA for CORO1A Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CORO1A Gene

Localization for CORO1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CORO1A Gene

Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle, phagosome membrane. Note=In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CORO1A gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
cytosol 4
mitochondrion 2
lysosome 2
endosome 2
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CORO1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 24760828
GO:0001891 phagocytic cup IDA 17442961
GO:0005634 NOT nucleus IDA 17341475
GO:0005737 cytoplasm IDA,IEA 17341475
GO:0005769 early endosome IEA --
genes like me logo Genes that share ontologies with CORO1A: view

Pathways & Interactions for CORO1A Gene

SuperPathways for CORO1A Gene

SuperPathway Contained pathways
1 Phagosome
2 Tuberculosis
genes like me logo Genes that share pathways with CORO1A: view

Pathways by source for CORO1A Gene

2 KEGG pathways for CORO1A Gene

Gene Ontology (GO) - Biological Process for CORO1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001771 NOT immunological synapse formation IMP 24760828
GO:0001845 phagolysosome assembly IEA,IMP 12132654
GO:0006816 calcium ion transport IEA --
GO:0006909 phagocytosis IMP 17442961
GO:0006928 movement of cell or subcellular component NAS 17341475
genes like me logo Genes that share ontologies with CORO1A: view

No data available for SIGNOR curated interactions for CORO1A Gene

Drugs & Compounds for CORO1A Gene

(1) Drugs for CORO1A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CORO1A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CORO1A: view

Transcripts for CORO1A Gene

Unigene Clusters for CORO1A Gene

Coronin, actin binding protein, 1A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CORO1A Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^
SP1: - - - - - - -
SP2: -
SP3: -
SP4: - - -
SP5: -
SP6: - - - - - - - - - -
SP7: - -
SP8: - - - - -
SP9: - - - - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - -
SP12:
SP13: -
SP14:

ExUns: 13 ^ 14a · 14b ^ 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for CORO1A Gene

GeneLoc Exon Structure for
CORO1A
ECgene alternative splicing isoforms for
CORO1A

Expression for CORO1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CORO1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CORO1A Gene

This gene is overexpressed in Whole Blood (x25.8) and Spleen (x5.0).

Protein differential expression in normal tissues from HIPED for CORO1A Gene

This gene is overexpressed in Lymph node (13.6), NK cells (9.5), and Tlymphocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CORO1A Gene



Protein tissue co-expression partners for CORO1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CORO1A Gene:

CORO1A

SOURCE GeneReport for Unigene cluster for CORO1A Gene:

Hs.415067

mRNA Expression by UniProt/SwissProt for CORO1A Gene:

P31146-COR1A_HUMAN
Tissue specificity: Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.

Evidence on tissue expression from TISSUES for CORO1A Gene

  • Blood(4.9)
  • Nervous system(4.9)
  • Kidney(4.3)
  • Liver(4.3)
  • Skin(4.2)
  • Spleen(4)
  • Intestine(2.8)
  • Bone marrow(2.6)
  • Lymph node(2.6)
  • Pancreas(2.4)
  • Lung(2.3)
  • Eye(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CORO1A Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • immune
  • lymphatic
  • nervous
  • respiratory
Organs:
Head and neck:
  • brain
  • head
General:
  • blood
  • bone marrow
  • white blood cell
genes like me logo Genes that share expression patterns with CORO1A: view

Primer Products

Orthologs for CORO1A Gene

This gene was present in the common ancestor of animals.

Orthologs for CORO1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CORO1A 34 35
  • 99.86 (n)
dog
(Canis familiaris)
Mammalia CORO1A 34 35
  • 92.26 (n)
cow
(Bos Taurus)
Mammalia CORO1A 34 35
  • 92.12 (n)
oppossum
(Monodelphis domestica)
Mammalia CORO1A 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Coro1a 34 16 35
  • 89.08 (n)
rat
(Rattus norvegicus)
Mammalia Coro1a 34
  • 88.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CORO1A 35
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CORO1A 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia coro2b 34
  • 72.48 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC69077 34
zebrafish
(Danio rerio)
Actinopterygii coro1a 34 35
  • 69.4 (n)
zgc63766 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6309 34
fruit fly
(Drosophila melanogaster)
Insecta coro 36
  • 57 (a)
worm
(Caenorhabditis elegans)
Secernentea cor-1 36
  • 51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.313 35
  • 40 (a)
OneToMany
Species where no ortholog for CORO1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CORO1A Gene

ENSEMBL:
Gene Tree for CORO1A (if available)
TreeFam:
Gene Tree for CORO1A (if available)

Paralogs for CORO1A Gene

Paralogs for CORO1A Gene

Pseudogenes.org Pseudogenes for CORO1A Gene

genes like me logo Genes that share paralogs with CORO1A: view

Variants for CORO1A Gene

Sequence variations from dbSNP and Humsavar for CORO1A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs397514755 Pathogenic, Immunodeficiency 8 (IMD8) [MIM:615401] 30,186,894(+) AGCGT(A/G)TGGGC upstream-variant-2KB, reference, missense
rs606231246 Pathogenic 30,186,647(+) AGCCC(-/CT)GTGCT upstream-variant-2KB, reference, frameshift-variant
rs606231256 Pathogenic 30,188,373(+) TGTTC(-/C)AGGAG reference, frameshift-variant
rs1000303536 -- 30,185,712(+) CACAG(A/G)GGGGG intron-variant, upstream-variant-2KB
rs1000675240 -- 30,185,227(+) GTGGT(A/C)CGCTC upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CORO1A Gene

Variant ID Type Subtype PubMed ID
esv22245 CNV gain 19812545
esv2758642 CNV gain 17122850
esv3364056 CNV duplication 20981092
nsv571819 CNV gain 21841781
nsv821543 CNV duplication 20802225
nsv9431 CNV gain+loss 18304495
nsv978130 CNV duplication 23825009

Variation tolerance for CORO1A Gene

Residual Variation Intolerance Score: 10.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CORO1A Gene

Human Gene Mutation Database (HGMD)
CORO1A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CORO1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CORO1A Gene

Disorders for CORO1A Gene

MalaCards: The human disease database

(7) MalaCards diseases for CORO1A Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency 8
  • severe combined immunodeficiency due to coro1a deficiency
coronin-1a deficiency
  • coronin 1a
tuberculoid leprosy
  • smooth leprosy
epidermodysplasia verruciformis
  • lewandowsky-lutz syndrome
molluscum contagiosum
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

COR1A_HUMAN
  • Immunodeficiency 8 (IMD8) [MIM:615401]: A disease of the immune system leading to recurrent infections, and characterized by CD4+ T-cells lymphopenia. Patients can develop B-cell lymphoproliferation associated with Epstein-Barr virus infection. {ECO:0000269 PubMed:19097825, ECO:0000269 PubMed:23522482}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CORO1A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CORO1A
genes like me logo Genes that share disorders with CORO1A: view

No data available for Genatlas for CORO1A Gene

Publications for CORO1A Gene

  1. Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein. (PMID: 9778037) Okumura M. … Thomas M.L. (DNA Cell Biol. 1998) 2 3 22 64
  2. Molecular cloning of a novel actin-binding protein, p57, with a WD repeat and a leucine zipper motif. (PMID: 7758584) Suzuki K. … Toyoshima S. (FEBS Lett. 1995) 3 4 22 64
  3. Whole-exome sequencing identifies Coronin-1A deficiency in 3 siblings with immunodeficiency and EBV-associated B-cell lymphoproliferation. (PMID: 23522482) Moshous D. … de Villartay J.P. (J. Allergy Clin. Immunol. 2013) 3 4 64
  4. Constitutive turnover of phosphorylation at Thr-412 of human p57/coronin-1 regulates the interaction with actin. (PMID: 23100250) Oku T. … Tsuji T. (J. Biol. Chem. 2012) 3 4 64
  5. Coronin-1 is associated with neutrophil survival and is cleaved during apoptosis: potential implication in neutrophils from cystic fibrosis patients. (PMID: 19454722) Moriceau S. … Witko-Sarsat V. (J. Immunol. 2009) 3 22 64

Products for CORO1A Gene

Sources for CORO1A Gene

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