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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CORO1A Gene

protein-coding   GIFtS: 59
GCID: GC16P030194

Coronin, Actin Binding Protein, 1A

(Previous names: coronin, actin-binding protein, 1A)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coronin, Actin Binding Protein, 1A1 2     HCORO12
TACO2 3 5     IMD82
Coronin-Like Protein A2 3     clipin-A2
Coronin-Like Protein P572 3     coronin-12
Tryptophan Aspartate-Containing Coat Protein2 3     coronin-1A2
CLIPINA2 5     p572
Clabp TACO1     CORO13
Coronin, Actin-Binding Protein, 1A1     Clipin-A3
CLABP2     

External Ids:    HGNC: 22521   Entrez Gene: 111512   Ensembl: ENSG000001028797   OMIM: 6050005   UniProtKB: P311463   

Export aliases for CORO1A gene to outside databases

Previous GC identifers: GC16M028961 GC16P030516 GC16P030193 GC16P030231 GC16P030103 GC16P027857


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CORO1A Gene:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of
approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation
of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular
processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative
splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16.
(provided by RefSeq, Sep 2010)

GeneCards Summary for CORO1A Gene: 
CORO1A (coronin, actin binding protein, 1A) is a protein-coding gene. Diseases associated with CORO1A include primary effusion lymphoma, and severe combined immunodeficiency due to coro1a deficiency. GO annotations related to this gene include actin filament binding and protein homodimerization activity. An important paralog of this gene is CORO1B.

UniProtKB/Swiss-Prot: COR1A_HUMAN, P31146
Function: May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the
invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane
involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents
fusion between phagosomes and lysosomes

Gene Wiki entry for CORO1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CORO1A gene promoter:
         CREB   deltaCREB   p300   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCORO1A promoter sequence
   Search SABiosciences Chromatin IP Primers for CORO1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CORO1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

CORO1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CORO1A gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P030194:  view genomic region     (about GC identifiers)

Start:
30,194,148 bp from pter      End:
30,200,397 bp from pter
Size:
6,250 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: COR1A_HUMAN, P31146 (See protein sequence)
Recommended Name: Coronin-1A  
Size: 461 amino acids; 51026 Da
Subunit: Binds actin
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cell cortex (By similarity). Cytoplasmic
vesicle, phagosome membrane (By similarity). Note=In non-infected macrophages, associated with the cortical
microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around
the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial
viability and not due to impaired acidification (By similarity)
Secondary accessions: B2RBL1 Q2YD73

Explore the universe of human proteins at neXtProt for CORO1A: NX_P31146

Explore proteomics data for CORO1A at MOPED 

Post-translational modifications:

  • UniProtKB: phosphorylation at Thr-412 by PKC strongly down-regulates the association with actin
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P31146

  • CORO1A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CORO1A Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001180262.1  NP_009005.1  

    ENSEMBL proteins: 
     ENSP00000456266   ENSP00000456756   ENSP00000219150   ENSP00000455552   ENSP00000456457  
     ENSP00000457332   ENSP00000454752   ENSP00000457509  

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    Cloud-Clone Corp. Proteins for CORO1A 

    Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001772immunological synapse IEA--
    GO:0001891phagocytic cup IDA17442961
    GO:0005634NOT nucleus IDA17341475
    GO:0005737cytoplasm IDA17341475
    GO:0005884actin filament IDA15800061

    CORO1A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing
    CORO: Coronins

    5/8 InterPro protein domains (see all 8):
     IPR027334 CORO1A
     IPR019775 WD40_repeat_CS
     IPR015049 DUF1900
     IPR001680 WD40_repeat
     IPR015505 Coronin

    Graphical View of Domain Structure for InterPro Entry P31146

    ProtoNet protein and cluster: P31146

    UniProtKB/Swiss-Prot: COR1A_HUMAN, P31146
    Similarity: Belongs to the WD repeat coronin family
    Similarity: Contains 7 WD repeats


    CORO1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COR1A_HUMAN, P31146
    Function: May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the
    invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane
    involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents
    fusion between phagosomes and lysosomes

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11094157
    GO:0008022protein C-terminus binding IPI9365277
    GO:0008092cytoskeletal protein binding ISS--
    GO:0042802identical protein binding ----
    GO:0042803protein homodimerization activity IDA15601263
         
    CORO1A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CORO1A:
     Decreased focal adhesion (FA)  

         4 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Coro1a):
     cellular  hematopoietic system  immune system  renal/urinary system 

    CORO1A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Coro1atm1Achn for CORO1A

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CORO1A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CORO1A

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    miRNA
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    miRTarBase miRNAs that target CORO1A:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CORO1A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Tuberculosis
    Tuberculosis
    2Phagosome
    Phagosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2         Kegg Pathways  (Kegg details for CORO1A):
        Phagosome
    Tuberculosis


    CORO1A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CORO1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/64 Interacting proteins for CORO1A (P311461, 3 ENSP000002191504) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTBP607093, ENSP000003499604I2D: score=2 STRING: ENSP00000349960
    DKK1O949073, ENSP000003630814I2D: score=2 STRING: ENSP00000363081
    UBE2G2P606043, ENSP000003383484I2D: score=2 STRING: ENSP00000338348
    THBS1P079963, ENSP000002603564I2D: score=2 STRING: ENSP00000260356
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001845phagolysosome assembly IMP12132654
    GO:0006816calcium ion transport IEA--
    GO:0006909phagocytosis IMP17442961
    GO:0006928cellular component movement NAS17341475
    GO:0007015actin filament organization IEA--

    CORO1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CORO1A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CORO1A (COR1A)

    2 Novoseek inferred chemical compound relationships for CORO1A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 37.8 6 15601263 (3), 7758584 (2)
    nadph 28.1 1 19454722 (1)

    Search CenterWatch for drugs/clinical trials and news about CORO1A / COR1A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CORO1A gene (2 alternative transcripts): 
    NM_001193333.2  NM_007074.3  

    Unigene Cluster for CORO1A:

    Coronin, actin binding protein, 1A
    Hs.415067  [show with all ESTs]
    Unigene Representative Sequence: AB209221
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000563778 ENST00000561815 ENST00000219150(uc010vej.2 uc010bzq.3 uc002dww.3)
    ENST00000564446 ENST00000568763(uc002dwx.3) ENST00000566619 ENST00000568982
    ENST00000570045 ENST00000569469 ENST00000565497 ENST00000570244 ENST00000569203
    ENST00000561849 ENST00000569970 ENST00000567034 ENST00000564768(uc002dwy.1)
    ENST00000562129
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB209221.1 AF495470.1 AK096332.1 AK097964.1 AK296207.1 AK314714.1 BC110374.1 BC126385.1 
    BC126387.1 D44497.1 GQ214031.1 U34690.1 X89109.1 

    24/30 DOTS entries (see all 30):

    DT.217513  DT.100670910  DT.100670905  DT.95099643  DT.95099640  DT.100670901  DT.91771416  DT.217515 
    DT.100670894  DT.120696984  DT.87015760  DT.101984658  DT.120697299  DT.70104382  DT.100656266  DT.92417158 
    DT.100670885  DT.120695588  DT.120696026  DT.120696748  DT.120697637  DT.120698053  DT.100640781  DT.100858855 

    24/696 AceView cDNA sequences (see all 696):

    BX483795 BQ053231 BQ642780 CR593420 BQ066156 CR611130 BU070693 AI799567 
    BQ065266 BM927423 AL548081 F04684 BQ054777 BM708311 BQ053151 BM714710 
    AA715843 CR618041 CR601300 U35342 BX427455 CR600248 AW770588 CR592681 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for CORO1A (see all 14)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^
    SP1:        -     -     -     -     -           -     -                                                                                                         
    SP2:                                                                                                                                                  -         
    SP3:                                                                                                                                                  -         
    SP4:                                -           -     -                                                                                                         
    SP5:                                                                                                                                                  -         

    ExUns: 13 ^ 14a · 14b ^ 15
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for CORO1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CORO1A expression in normal human tissues (normalized intensities)      CORO1A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGAGAAAA
    CORO1A Expression
    About this image


    CORO1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 9 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Peripheral blood Pan-T Cells   
     
     Lymph (Hematopoietic System)    fully expand to see all 4 entries
             lymph node ; non-germinal center cells   
             LYMPH NODE   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             ganglion/cranial/trigeminal V   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
             Cord Blood CD133- Cells   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Mononuclear Myocytes Hyoid Arch Muscles

    See CORO1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CORO1A

    SOURCE GeneReport for Unigene cluster: Hs.415067

    UniProtKB/Swiss-Prot: COR1A_HUMAN, P31146
    Tissue specificity: Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORO1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CORO1A gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Coro1a1 , 5 coronin, actin binding protein 1A1, 5 89.08(n)1
    94.58(a)1
      7 (69.25 cM)5
    127211  NM_009898.21  NP_034028.11 
     1266997735 
    lizard
    (Anolis carolinensis)
    Reptilia CORO1A6
    Coronin
    66(a)
    1 ↔ 1
    GL343279.1(434271-444188)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC690772 hypothetical protein MGC69077 78.7(n)    BC060754.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc637662 similar to coronin, actin binding protein, 1A 77.95(n)   394089  BC055237.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta coro3 actin binding 57(a)   42D4   --
    worm
    (Caenorhabditis elegans)
    Secernentea cor-13 Coronin (beta transducin) 51(a)   III(10320798-10326235)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CRN16
    Coronin, cortical actin cytoskeletal component tha...
    27(a)
    1 → many
    XII(990777-992732)


    ENSEMBL Gene Tree for CORO1A (if available)
    TreeFam Gene Tree for CORO1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CORO1A gene
    CORO1B2  CORO7-PAM162  CORO62  CORO72  CORO1C2  CORO2B2  CORO2A2  
    8 SIMAP similar genes for CORO1A using alignment to 7 protein entries:     COR1A_HUMAN (see all proteins):
    DKFZp762I166    CORO1C    CORO1B    CORO6    CORO2A    CORO2B
    CORO7    CORO7-PAM16

    CORO1A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CORO1A
    PGOHUM00000262324


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/187 SNPs in CORO1A are shown (see all 187)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10535741,2,4
    F--27862870(+) AGGCCA/CCGGTG 6 T A S mis1 ese31Minor allele frequency- C:0.02MN 184
    rs713894501,2
    C--27863206(+) AAACCG/AGCCAT 2 -- ds50012Minor allele frequency- A:0.25NA 4
    rs1840572291,2
    --31091092(+) GCGCAA/CACCAC 2 -- us2k10--------
    rs1468565151,2
    C--31091311(+) TCGCTC/GTGTCA 2 -- us2k10--------
    rs1888411171,2
    --31091367(+) CGCCTC/TCTGGG 2 -- us2k10--------
    rs1392420221,2
    C--31091466(+) AGAGAC/GGGGGT 2 -- us2k10--------
    rs1815661031,2
    C--31091478(+) TCACCA/GTGTTA 2 -- us2k10--------
    rs1420945751,2
    C--31091493(+) GGATGA/GTCTCC 2 -- us2k10--------
    rs1501101741,2
    --31091512(+) ACCTCA/GTGATC 2 -- us2k10--------
    rs1870255221,2
    C--31091518(+) TGATCC/TGCCCG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CORO1A (30194148 - 30200397 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CORO1A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv821543CNV Duplication20802225
    nsv905723CNV Loss21882294
    nsv905722CNV Loss21882294
    nsv905721CNV Loss21882294
    nsv905720CNV Loss21882294
    esv22245CNV Gain19812545
    nsv9431CNV Gain+Loss18304495
    dgv847e1CNV Complex17122850
    dgv846e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): CORO1A
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CORO1A
    DNA2.0 Custom Variant and Variant Library Synthesis for CORO1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605000    OMIM disorders: --

    10 diseases for CORO1A:    About MalaCards
    primary effusion lymphoma    severe combined immunodeficiency due to coro1a deficiency    chronic granulomatous disease    astigmatism
    pulmonary tuberculosis    severe combined immunodeficiency    attention deficit hyperactivity disorder    endometriosis
    cystic fibrosis    tuberculosis


    CORO1A for disorders           About GeneDecksing


    Export disorders for CORO1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CORO1A gene, integrated from 9 sources (see all 62):
    (articles sorted by number of sources associating them with CORO1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel actin-binding protein, p57, with a WD repeat and a leucine zipper motif. (PubMed id 7758584)1, 2, 9 Suzuki K....Toyoshima S. (1995)
    2. Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein. (PubMed id 9778037)1, 3, 9 Okumura M....Thomas M.L. (1998)
    3. Constitutive turnover of phosphorylation at Thr-412 of human p57/coronin-1 regulates the interaction with actin. (PubMed id 23100250)1, 2 Oku T....Tsuji T. (2012)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A coat protein on phagosomes involved in the intracellular survival of mycobacteria. (PubMed id 10338208)1, 2 Ferrari G.... Pieters J. (1999)
    7. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)1, 2 Rasmussen H.H....Vandekerckhove J. (1992)
    8. Coronin-1 is associated with neutrophil survival and is cleaved during apoptosis: potential implication in neutrophils from cystic fibrosis patients. (PubMed id 19454722)1, 9 Moriceau S....Witko-Sarsat V. (2009)
    9. Phorbol ester-dependent phosphorylation regulates the association of p57/coronin-1 with the actin cytoskeleton. (PubMed id 18693254)1, 9 Oku T....Tsuji T. (2008)
    10. Homotypic dimerization of the actin-binding protein p57/coronin-1 mediated by a leucine zipper motif in the C-terminal region. (PubMed id 15601263)1, 9 Oku T....Tsuji T. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11151 HGNC: 2252 AceView: CORO1A Ensembl:ENSG00000102879 euGenes: HUgn11151
    ECgene: CORO1A Kegg: 11151 H-InvDB: CORO1A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CORO1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CORO1A gene:
    Search GeneIP for patents involving CORO1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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