Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CORIN Gene

Aliases for CORIN Gene

  • Corin, Serine Peptidase 2 3 5
  • Heart-Specific Serine Proteinase ATC2 3 4
  • Transmembrane Protease Serine 10 3 4
  • Pro-ANP-Converting Enzyme 3 4
  • TMPRSS10 3 4
  • CRN 3 4
  • Atrial Natriuretic Peptide-Converting Enzyme 3
  • Corin, Serine Protease 2
  • Pro-ANP-Convertase 3
  • EC 3.4.21.- 4
  • EC 3.4.21 61
  • Corin 4
  • ATC2 3
  • Lrp4 3
  • PEE5 3

External Ids for CORIN Gene

Previous GeneCards Identifiers for CORIN Gene

  • GC04M047512
  • GC04M047436
  • GC04M047290
  • GC04M046915

Summaries for CORIN Gene

Entrez Gene Summary for CORIN Gene

  • This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

GeneCards Summary for CORIN Gene

CORIN (Corin, Serine Peptidase) is a Protein Coding gene. Diseases associated with CORIN include Preeclampsia/Eclampsia 5 and Systolic Heart Failure. Among its related pathways are Cardiac conduction and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include serine-type endopeptidase activity and serine-type exopeptidase activity. An important paralog of this gene is ST14.

UniProtKB/Swiss-Prot for CORIN Gene

  • Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide.

  • Isoform 2: has weaker endopeptidase activity compared to isoform 1.

Gene Wiki entry for CORIN Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORIN Gene

Genomics for CORIN Gene

Regulatory Elements for CORIN Gene

Enhancers for CORIN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G047836 0.9 ENCODE 0.7 +0.9 909 1.6 ELF3 PKNOX1 ARID4B ZNF48 RAD21 GLIS2 ZNF143 IKZF2 MIXL1 THAP11 NFXL1 CNGA1 CORIN LOC101927179
GH04G047838 0.8 Ensembl ENCODE 0.7 -1.2 -1192 0.6 CTCF EED IKZF1 TRIM22 SMC3 EP300 RAD21 NFXL1 CNGA1 GC04P047839 CORIN
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CORIN on UCSC Golden Path with GeneCards custom track

Promoters for CORIN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000168070 906 1601 ELF3 PKNOX1 SIN3A ARID4B ZNF48 RAD21 GLIS2 ZNF143 IKZF2 MIXL1

Genomic Location for CORIN Gene

Chromosome:
4
Start:
47,593,998 bp from pter
End:
47,838,106 bp from pter
Size:
244,109 bases
Orientation:
Minus strand

Genomic View for CORIN Gene

Genes around CORIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORIN Gene

Proteins for CORIN Gene

  • Protein details for CORIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Q5-CORIN_HUMAN
    Recommended name:
    Atrial natriuretic peptide-converting enzyme
    Protein Accession:
    Q9Y5Q5
    Secondary Accessions:
    • B0ZBE3
    • Q2TBD2
    • Q4W5E5
    • Q4W5G6
    • Q9UHY2

    Protein attributes for CORIN Gene

    Size:
    1042 amino acids
    Molecular mass:
    116486 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Initially named CORIN due to its abundant expression in the heart.

    Alternative splice isoforms for CORIN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CORIN Gene

Selected DME Specific Peptides for CORIN Gene

Q9Y5Q5:
  • CYITGWG
  • GDSGGPL
  • SGGPLVC

Post-translational modifications for CORIN Gene

  • A disulfide bond links the activated corin protease fragment and the N-terminal propeptide. The disulfide bond also links the activated corin protease fragment with soluble fragments (100 kDa, 160 kDa and 180 kDa fragments).
  • Activated through proteolytic processing by a trypsin-like protease; cleaved into a N-terminal propeptide and an activated corin protease fragment. Different soluble forms are produced by cleavage and autocatalytic cleavage: Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment is produced by cleavage by ADAM10, while 160 kDa and 100 kDa soluble fragments are produced by autocatalytic cleavage. Cleavage by ADAM10 to produce soluble 180 kDa soluble fragment takes place after the transmembrane region and before FZ 1.
  • N-glycosylated; required for processing and activation.
  • Glycosylation at Asn80, isoforms=2104, Asn135, Asn141, isoforms=2231, isoforms=2245, isoforms=2251, isoforms=2305, Asn320, isoforms=2376, isoforms=2413, isoforms=2446, Asn451, Asn469, isoforms=2567, isoforms=2651, Asn697, Asn761, and Asn1022
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for CORIN

Assay Products

  • Cloud-Clone Corp Assay Kits for CORIN

Domains & Families for CORIN Gene

Suggested Antigen Peptide Sequences for CORIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5Q5

UniProtKB/Swiss-Prot:

CORIN_HUMAN :
  • The DDNN motif is required for targeting to the cell membrane and enzyme activation.
  • Belongs to the peptidase S1 family.
Domain:
  • The DDNN motif is required for targeting to the cell membrane and enzyme activation.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with CORIN: view

Function for CORIN Gene

Molecular function for CORIN Gene

GENATLAS Biochemistry:
corin,transmembrane serine protease,expressed only in the heart in the primary atrial septum and the trabecular ventricular compartment
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.28 mM for pyroGlu-Phe-Lys-pNA.HCl {ECO:0000269 PubMed:14559895}; KM=3.52 mM for pyroGlu-Pro-Arg-pNA.HCl {ECO:0000269 PubMed:14559895}; KM=2.95 mM for H-D-Pro-Phe-Arg-pNA.2HCl {ECO:0000269 PubMed:14559895}; KM=1.92 mM for Bz-Ile-Glu-(gamma-OR)-Gly-Arg-pNA.HCl {ECO:0000269 PubMed:14559895}; KM=16 mM for pyroGlu-Gly-Arg-pNA.HCl {ECO:0000269 PubMed:14559895};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited in a dose-dependent manner by non-specific trypsin-like serine protease inhibitors including benzamidine.
UniProtKB/Swiss-Prot Function:
Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide.
UniProtKB/Swiss-Prot Function:
Isoform 2: has weaker endopeptidase activity compared to isoform 1.

Enzyme Numbers (IUBMB) for CORIN Gene

Gene Ontology (GO) - Molecular Function for CORIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA,TAS --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CORIN: view
genes like me logo Genes that share phenotypes with CORIN: view

Human Phenotype Ontology for CORIN Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CORIN Gene

MGI Knock Outs for CORIN:

Animal Model Products

  • Taconic Biosciences Mouse Models for CORIN

miRNA for CORIN Gene

Inhibitory RNA Products

No data available for Transcription Factor Targets and HOMER Transcription for CORIN Gene

Localization for CORIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for CORIN Gene

Cell membrane; Single-pass type II membrane protein. Note=May easily detached from the endothelial cell membrane.
Isoform 2: Cell membrane; Single-pass type II membrane protein. Note=Less efficiently targeted to the cell membrane compared to isoform 1.
Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment: Secreted. Note=Soluble form produced following cleavage by ADAM10.
Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment: Secreted. Note=Soluble form produced following autocatalytic cleavage.
Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment: Secreted. Note=Soluble form produced following autocatalytic cleavage.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CORIN gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytoskeleton 4
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CORIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IDA,TAS --
GO:0009986 cell surface IEA --
GO:0015629 actin cytoskeleton IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CORIN: view

Pathways & Interactions for CORIN Gene

genes like me logo Genes that share pathways with CORIN: view

Pathways by source for CORIN Gene

1 BioSystems pathway for CORIN Gene
3 Reactome pathways for CORIN Gene

Gene Ontology (GO) - Biological Process for CORIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide ISS --
GO:0006508 proteolysis IEA --
GO:0007565 female pregnancy IMP 22437503
GO:0008217 regulation of blood pressure ISS,IEA --
GO:0016486 peptide hormone processing IDA,IEA 10880574
genes like me logo Genes that share ontologies with CORIN: view

No data available for SIGNOR curated interactions for CORIN Gene

Drugs & Compounds for CORIN Gene

(1) Drugs for CORIN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CORIN: view

Transcripts for CORIN Gene

Unigene Clusters for CORIN Gene

Corin, serine peptidase:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CORIN Gene

No ASD Table

Relevant External Links for CORIN Gene

GeneLoc Exon Structure for
CORIN
ECgene alternative splicing isoforms for
CORIN

Expression for CORIN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CORIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CORIN Gene

This gene is overexpressed in Heart - Atrial Appendage (x19.0) and Heart - Left Ventricle (x13.0).

Protein differential expression in normal tissues from HIPED for CORIN Gene

This gene is overexpressed in Heart (36.8) and Pancreatic juice (27.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CORIN Gene



Protein tissue co-expression partners for CORIN Gene

NURSA nuclear receptor signaling pathways regulating expression of CORIN Gene:

CORIN

SOURCE GeneReport for Unigene cluster for CORIN Gene:

Hs.518618

mRNA Expression by UniProt/SwissProt for CORIN Gene:

Q9Y5Q5-CORIN_HUMAN
Tissue specificity: Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus. Detected in blood, in plasma as well as in serum (at protein level).

Evidence on tissue expression from TISSUES for CORIN Gene

  • Heart(4.6)
  • Muscle(2.6)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CORIN Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • nervous
  • respiratory
  • urinary
Organs:
Head and neck:
  • brain
  • ear
  • eye
  • head
Thorax:
  • heart
  • lung
Abdomen:
  • intestine
  • kidney
  • liver
  • small intestine
  • stomach
General:
  • blood
  • blood vessel
  • coagulation system
  • red blood cell
  • skin
genes like me logo Genes that share expression patterns with CORIN: view

Orthologs for CORIN Gene

This gene was present in the common ancestor of animals.

Orthologs for CORIN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CORIN 34 35
  • 99.46 (n)
cow
(Bos Taurus)
Mammalia CORIN 34 35
  • 88.14 (n)
mouse
(Mus musculus)
Mammalia Corin 34 16 35
  • 83.74 (n)
rat
(Rattus norvegicus)
Mammalia Corin 34
  • 83.27 (n)
dog
(Canis familiaris)
Mammalia CORIN 34 35
  • 83.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 75 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 21 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CORIN 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves CORIN 34 35
  • 75.48 (n)
lizard
(Anolis carolinensis)
Reptilia CORIN 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia corin 34
  • 70.16 (n)
zebrafish
(Danio rerio)
Actinopterygii CORIN (2 of 2) 35
  • 67 (a)
OneToMany
si:ch1073-76a20.1 34
  • 60.87 (n)
CORIN (1 of 2) 35
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1632 35
  • 14 (a)
ManyToMany
Corin 35
  • 12 (a)
ManyToMany
ndl 35
  • 6 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3795 35
  • 23 (a)
OneToOne
Species where no ortholog for CORIN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CORIN Gene

ENSEMBL:
Gene Tree for CORIN (if available)
TreeFam:
Gene Tree for CORIN (if available)

Paralogs for CORIN Gene

Variants for CORIN Gene

Sequence variations from dbSNP and Humsavar for CORIN Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs387906894 Pathogenic, Pre-eclampsia/eclampsia 5 (PEE5) [MIM:614595] 47,683,803(-) CAGGC(A/G)AGTGC reference, missense
rs387906895 Pathogenic, Pre-eclampsia/eclampsia 5 (PEE5) [MIM:614595] 47,665,207(-) GTACA(A/G)GTTAT reference, missense
rs193921036 Uncertain significance 47,665,221(-) TTTGC(C/G)CTACA reference, missense
rs201223301 Uncertain significance 47,661,831(+) ACAGC(A/G)TTCTT reference, missense
rs1000009526 -- 47,809,292(+) TAGAG(A/G)CCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CORIN Gene

Variant ID Type Subtype PubMed ID
dgv5202n100 CNV gain 25217958
esv2660213 CNV deletion 23128226
esv2727531 CNV deletion 23290073
esv2762430 CNV loss 21179565
esv27666 CNV loss 19812545
esv3335763 CNV insertion 20981092
esv3563830 CNV deletion 23714750
esv3569414 CNV loss 25503493
esv3600452 CNV loss 21293372
esv3600453 CNV loss 21293372
esv3600454 CNV loss 21293372
esv3600455 CNV loss 21293372
nsv1003341 CNV gain 25217958
nsv1116401 CNV insertion 24896259
nsv4328 CNV deletion 18451855
nsv476406 CNV novel sequence insertion 20440878
nsv478737 CNV novel sequence insertion 20440878
nsv594118 CNV loss 21841781
nsv822557 CNV loss 20364138
nsv829923 CNV gain 17160897
nsv829924 CNV gain 17160897
nsv967742 CNV duplication 23825009

Variation tolerance for CORIN Gene

Residual Variation Intolerance Score: 39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.66; 65.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CORIN Gene

Human Gene Mutation Database (HGMD)
CORIN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CORIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CORIN Gene

Disorders for CORIN Gene

MalaCards: The human disease database

(7) MalaCards diseases for CORIN Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
preeclampsia/eclampsia 5
  • corin
systolic heart failure
  • heart failure, systolic
preeclampsia/eclampsia 1
  • preeclampsia
pre-eclampsia
  • preeclampsia
total anomalous pulmonary venous return
  • total anomalous pulmonary venous return 1
- elite association - COSMIC cancer census association via MalaCards
Search CORIN in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CORIN_HUMAN
  • Pre-eclampsia/eclampsia 5 (PEE5) [MIM:614595]: A hypertensive disorder of pregnancy characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks gestation with clinically relevant proteinuria. It impacts 2 individuals, the mother and her child, both of whom can be severely affected. Preeclampsia is one of the causes of maternal mortality and morbidity worldwide. {ECO:0000269 PubMed:22437503}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CORIN

Genetic Association Database (GAD)
CORIN
Human Genome Epidemiology (HuGE) Navigator
CORIN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CORIN
genes like me logo Genes that share disorders with CORIN: view

No data available for Genatlas for CORIN Gene

Publications for CORIN Gene

  1. Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart. (PMID: 10329693) Yan W. … Wu Q. (J. Biol. Chem. 1999) 2 3 4 22 64
  2. Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting. (PMID: 19326473) Fox A.A. … Body S.C. (Anesthesiology 2009) 3 22 46 64
  3. Role of glycosylation in corin zymogen activation. (PMID: 17660514) Liao X. … Wu Q. (J. Biol. Chem. 2007) 3 4 22 64
  4. Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension. (PMID: 16216958) Dries D.L. … Drazner M.H. (Circulation 2005) 3 22 46 64
  5. Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin. (PMID: 14559895) Knappe S. … Wu Q. (J. Biol. Chem. 2003) 3 4 22 64

Products for CORIN Gene

Sources for CORIN Gene

Content
Loading form....