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CORIN Gene

protein-coding   GIFtS: 58
GCID: GC04M047596

Corin, Serine Peptidase

(Previous names: corin, serine protease)
  See CORIN-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Corin, Serine Peptidase1 2     Corin, Serine Protease1
CRN2 3 5     Lrp42
TMPRSS102 3 5     Atrial Natriuretic Peptide-Converting Enzyme2
Heart-Specific Serine Proteinase ATC22 3     pro-ANP-convertase2
Pro-ANP-Converting Enzyme2 3     Corin3
Transmembrane Protease Serine 102 3     EC 3.4.21.-3
ATC22 5     EC 3.4.218
PEE52 5     

External Ids:    HGNC: 190121   Entrez Gene: 106992   Ensembl: ENSG000001452447   OMIM: 6052365   UniProtKB: Q9Y5Q53   

Export aliases for CORIN gene to outside databases

Previous GC identifers: GC04M047512 GC04M047436 GC04M047290 GC04M046915


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CORIN Gene:
This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members
of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial
natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood
volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple
alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jun 2013)

GeneCards Summary for CORIN Gene:
CORIN (corin, serine peptidase) is a protein-coding gene. Diseases associated with CORIN include preeclampsia/eclampsia 5, and cone-rod dystrophy 18. GO annotations related to this gene include serine-type exopeptidase activity and serine-type endopeptidase activity. An important paralog of this gene is CFI.

UniProtKB/Swiss-Prot: CORIN_HUMAN, Q9Y5Q5
Function: Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts
through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood
pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also
plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also
acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide
Function: Isoform 2: has weaker endopeptidase activity compared to isoform 1

Gene Wiki entry for CORIN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_006238.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CORIN gene promoter:
         AML1a   POU2F1   HSF2   POU2F1a   MIF-1   Nkx2-5   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCORIN promoter sequence
   Search Chromatin IP Primers for CORIN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CORIN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p13-p12   Ensembl cytogenetic band:  4p12   HGNC cytogenetic band: 4p13-p12

CORIN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CORIN gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M047596:  view genomic region     (about GC identifiers)

Start:
47,596,015 bp from pter      End:
47,840,123 bp from pter
Size:
244,109 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CORIN_HUMAN, Q9Y5Q5 (See protein sequence)
Recommended Name: Atrial natriuretic peptide-converting enzyme  
Size: 1042 amino acids; 116486 Da
Miscellaneous: Initially named CORIN due to its abundant expression in the heart (PubMed:10329693)
Secondary accessions: B0ZBE3 Q2TBD2 Q4W5E5 Q4W5G6 Q9UHY2
Alternative splicing: 2 isoforms:  Q9Y5Q5-1   Q9Y5Q5-2   

Explore the universe of human proteins at neXtProt for CORIN: NX_Q9Y5Q5

Explore proteomics data for CORIN at MOPED

Post-translational modifications: 

  • N-glycosylated; required for processing and activation1
  • Activated through proteolytic processing by a trypsin-like protease; cleaved into a N-terminal propeptide and an
    activated corin protease fragment. Different soluble forms are produced by cleavage and autocatalytic cleavage:
    Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment is produced by cleavage by ADAM10, while
    160 kDa and 100 kDa soluble fragments are produced by autocatalytic cleavage. Cleavage by ADAM10 to produce
    soluble 180 kDa soluble fragment takes place after the transmembrane region and before FZ 11
  • A disulfide bond links the activated corin protease fragment and the N-terminal propeptide. The disulfide bond
    also links the activated corin protease fragment with soluble fragments (100 kDa, 160 kDa and 180 kDa fragments)1
  • Glycosylation2 at Asn80, Asn104, Asn135, Asn141, Asn231, Asn245, Asn251, Asn305, Asn320, Asn376,
                                 Asn413, Asn446, Asn451, Asn469, Asn567, Asn651, Asn697, Asn761, Asn1022
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for CORIN (Q9Y5Q5)
     CYITGWG  GDSGGPL  SGGPLVC 


    See CORIN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001265514.1  NP_001265515.1  NP_006578.2  

    ENSEMBL proteins: 
     ENSP00000273857   ENSP00000425597   ENSP00000424212   ENSP00000425401   ENSP00000423216  

    CORIN Human Recombinant Protein Products:

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    Novus Biologicals CORIN Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CORIN 

     
    antibodies-online proteins for CORIN (11 products) 

     
    antibodies-online peptides for CORIN

    CORIN Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals CORIN Antibodies
    Abcam antibodies for CORIN
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for CORIN
    antibodies-online antibodies for CORIN (47 products) 

    CORIN Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CORIN
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CORIN 
    antibodies-online kits for CORIN (23 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TMPRSS: Serine peptidases / Transmembrane

    Selected InterPro protein domains (see all 8):
     IPR017052 Peptidase_S1A_corin
     IPR023415 LDLR_class-A_CS
     IPR020067 Frizzled_dom
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry Q9Y5Q5

    ProtoNet protein and cluster: Q9Y5Q5

    3 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature
    IPB002172 Low density lipoprotein-receptor


    UniProtKB/Swiss-Prot: CORIN_HUMAN, Q9Y5Q5
    Domain: The DDNN motif is required for targeting to the cell membrane and enzyme activation (PubMed:21518754)
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 2 FZ (frizzled) domains
    Similarity: Contains 7 LDL-receptor class A domains
    Similarity: Contains 1 peptidase S1 domain
    Similarity: Contains 1 SRCR domain


    Find genes that share domains with CORIN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CORIN_HUMAN, Q9Y5Q5
    Function: Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts
    through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood
    pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also
    plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also
    acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide
    Function: Isoform 2: has weaker endopeptidase activity compared to isoform 1
    Enzyme regulation: Inhibited in a dose-dependent manner by non-specific trypsin-like serine protease inhibitors
    including benzamidine
    Biophysicochemical properties: Kinetic parameters: KM=1.28 mM for pyroGlu-Phe-Lys-pNA.HCl; KM=3.52 mM for
    pyroGlu-Pro-Arg-pNA.HCl; KM=2.95 mM for H-D-Pro-Phe-Arg-pNA.2HCl; KM=1.92 mM for
    Bz-Ile-Glu-(gamma-OR)-Gly-Arg-pNA.HCl; KM=16 mM for pyroGlu-Gly-Arg-pNA.HCl;

         Genatlas biochemistry entry for CORIN:
    corin,transmembrane serine protease,expressed only in the heart in the primary atrial septum and the trabecular
    ventricular compartment

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IDA10880574
    GO:0005044scavenger receptor activity IEA--
    GO:0005515protein binding ----
    GO:0070008serine-type exopeptidase activity IEA--
         
    Find genes that share ontologies with CORIN           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CORIN:
     Increased Salmonella enterica   Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Corin):
     cardiovascular system  cellular  growth/size/body  homeostasis/metabolism  integument 
     muscle  pigmentation  renal/urinary system 

    Find genes that share phenotypes with CORIN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Corintm1Qwu for CORIN

       genOway: Develop your customized and physiologically relevant rodent model for CORIN

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CORIN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CORIN (see all 31):
    hsa-miR-1287 hsa-miR-34b* hsa-miR-3673 hsa-miR-520e hsa-miR-302d hsa-miR-485-3p hsa-miR-302e hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmidCORIN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CORIN
    Predesigned siRNA for gene silencing in human, mouse, rat CORIN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CORIN

    Clone
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    OriGene clones in human, mouse for CORIN (see all 8)
    OriGene ORF clones in mouse, rat for CORIN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CORIN (NM_006587)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CORIN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CORIN

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CORIN
    Browse ESI BIO Cell Lines and PureStem Progenitors for CORIN 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORIN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CORIN_HUMAN, Q9Y5Q5: Cell membrane; Single-pass type II membrane protein. Note=May easily detached from the
    endothelial cell membrane
    CORIN_HUMAN, Q9Y5Q5: Isoform 2: Cell membrane; Single-pass type II membrane protein. Note=Less efficiently
    targeted to the cell membrane compared to isoform 1
    CORIN_HUMAN, Q9Y5Q5: Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment: Secreted.
    Note=Soluble form produced following cleavage by ADAM10
    CORIN_HUMAN, Q9Y5Q5: Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment: Secreted.
    Note=Soluble form produced following autocatalytic cleavage
    CORIN_HUMAN, Q9Y5Q5: Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment: Secreted.
    Note=Soluble form produced following autocatalytic cleavage
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane IEA--
    GO:0005887integral component of plasma membrane IDA--
    GO:0009986cell surface IEA--
    GO:0016020membrane ----

    Find genes that share ontologies with CORIN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CORIN About    
    See pathways by source

    SuperPathContained pathways About
    1Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43


    1 BioSystems Pathway for CORIN
        Myometrial Relaxation and Contraction Pathways


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CORIN
    Interactions:

        GeneGlobe Interaction Network for CORIN

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CORIN (ENSP000002738574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC1ENSP000003626494STRING: ENSP00000362649
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003050regulation of systemic arterial blood pressure by atrial natriuretic peptide ISS--
    GO:0006508proteolysis IDA--
    GO:0007565female pregnancy IMP--
    GO:0008217regulation of blood pressure ISS--
    GO:0016486peptide hormone processing IDA10880574

    Find genes that share ontologies with CORIN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CORIN

    1 Novoseek inferred chemical compound relationship for CORIN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 62.9 19 10880574 (2), 17485366 (2), 12154094 (1), 15192093 (1) (see all 14)



    Find genes that share compounds with CORIN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CORIN gene (3 alternative transcripts): 
    NM_001278585.1  NM_001278586.1  NM_006587.3  

    Unigene Cluster for CORIN:

    Corin, serine peptidase
    Hs.518618  [show with all ESTs]
    Unigene Representative Sequence: BX648285
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273857(uc011bzf.2 uc003gxm.3 uc011bzg.2) ENST00000508498
    ENST00000502252 ENST00000505909 ENST00000515827 ENST00000505754 ENST00000504584(uc011bzh.1)
    ENST00000503821(uc011bzi.1) ENST00000502726(uc003gxn.4) ENST00000510974

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CORIN (see all 31):
    hsa-miR-1287 hsa-miR-34b* hsa-miR-3673 hsa-miR-520e hsa-miR-302d hsa-miR-485-3p hsa-miR-302e hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmidCORIN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CORIN
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CORIN (NM_006587)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CORIN
      QuantiTect SYBR Green Assays in human, mouse, rat CORIN
      QuantiFast Probe-based Assays in human, mouse, rat CORIN

    Additional mRNA sequence: 

    AF113248.1 AF133845.1 AK297675.1 AK302816.1 AK304038.1 AK304466.1 BC110451.2 BX648285.1 

    5 DOTS entries:

    DT.309431  DT.101970734  DT.307667  DT.92420689  DT.102839486 

    Selected AceView cDNA sequences (see all 102):

    BF221651 BM468006 AF133845 BM466645 BM781738 AA908176 AK131285 BF971191 
    AA906367 AI700455 AI890823 AI420051 AI354875 BF108827 BU620685 NM_006587 
    BG773458 BC040151 AL697900 AA046682 AI625201 AI743731 AL045683 AW082849 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CORIN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGTTTTGG
    CORIN Expression
    About this image


    CORIN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 7 entries
             Early Floor Plate Cells Mesencephalic Floor Plate
             Metencephalon
             Otx2+Corin+ cells
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Early Floor Plate Cells Mesencephalic Floor Plate
             Medulla Oblongata
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Growth Plate
             HyStem+BMP4-induced SK11 cells
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Heart (Cardiovascular System)
             Cardiomyocyte-like progenitor cells
    CORIN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CORIN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.518618

    UniProtKB/Swiss-Prot: CORIN_HUMAN, Q9Y5Q5
    Tissue specificity: Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus.
    Detected in blood, in plasma as well as in serum (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORIN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CORIN gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Corin1 , 5 corin1, 5 83.74(n)1
    83.68(a)1
      5 (38.44 cM)5
    534191  NM_016869.31  NP_058565.21 
     723000255 
    chicken
    (Gallus gallus)
    Aves CORIN1 corin, serine peptidase 75.48(n)
    77.56(a)
      100857733  XM_003641209.2  XP_003641257.2 
    lizard
    (Anolis carolinensis)
    Reptilia CORIN6
    corin, serine peptidase
    70(a)
    1 ↔ 1
    GL343293.1(365038-504289)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia corin1 corin, serine peptidase 70.16(n)
    71.32(a)
      100492163  XM_002933462.2  XP_002933508.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch1073-76a20.11 si:ch1073-76a20.1 60.87(n)
    58.48(a)
      100320926  XM_005174157.1  XP_005174214.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ndl6
    CG16326
    (see all 3)
    --
    6(a)
    14(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    3L(6587038-6596466)
    X(8146705-8166495)


    ENSEMBL Gene Tree for CORIN (if available)
    TreeFam Gene Tree for CORIN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CORIN gene
    CFI2  
    Selected SIMAP similar genes for CORIN using alignment to 5 protein entries:     CORIN_HUMAN (see all proteins) (see all similar genes):
    F12    DKFZp586F0824    PRSS45    PRSS46    TMPRSS11B    CTRL
    PRSS41    TMPRSS11D    CTRC    CTRB1    CELA2B    CELA1
    CTRB2    FRZB    GZMM    PRSS42    TMPRSS2    ELA2A

    Find genes that share paralogs with CORIN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CORIN (see all 4699)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0677974
    Pre-eclampsia/eclampsia 5 (PEE5)4--see VAR_0677972 S G mis40--------
    VAR_0677954
    Pre-eclampsia/eclampsia 5 (PEE5)4--see VAR_0677952 K E mis40--------
    rs355314031,2
    C--46944619(+) TAACC-/CTCTCT
    /CTCTCTCT
    TCTCT
    2 -- int1 cds10--------
    rs1114305601,2
    C,F--47074731(+) GTGTAC/TGAACA 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1867909281,2
    --47093628(+) GATAGA/GTAGAT 1 -- int10--------
    rs1469676331,2
    --47093636(+) GATAGA/GTAGGT 1 -- int10--------
    rs1492761091,2
    --47138368(+) ACGTG-/CACACAC 1 -- int10--------
    rs1394396781,2
    C--47138369(+) ACGTG-/CACA  
            
    CACAC
    1 -- int10--------
    rs1130245981,2
    C--47138379(+) ACACAG/CACACA 1 -- int11Minor allele frequency- C:0.50WA 2
    rs100055061,2
    C,F,H--47475461(+) TTAAAG/AGGTCA 1 -- ds50019Minor allele frequency- A:0.05NS EA NA WA 1208

    HapMap Linkage Disequilibrium report for CORIN (47596015 - 47840123 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CORIN:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660213CNV Deletion23128226
    esv2727531CNV Deletion23290073
    nsv822557CNV Loss20364138
    nsv879007CNV Loss21882294
    nsv4328CNV Loss18451855
    esv27666CNV Loss19812545
    nsv829923CNV Gain17160897
    nsv829924CNV Gain17160897

    Human Gene Mutation Database (HGMD): CORIN
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CORIN
    DNA2.0 Custom Variant and Variant Library Synthesis for CORIN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605236   
    OMIM disorders: 614595  
    UniProtKB/Swiss-Prot: CORIN_HUMAN, Q9Y5Q5
  • Pre-eclampsia/eclampsia 5 (PEE5) [MIM:614595]: A hypertensive disorder of pregnancy characterized by new
    hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant
    proteinuria. It impacts 2 individuals, the mother and her child, both of whom can be severely affected.
    Preeclampsia is one of the causes of maternal mortality and morbidity worldwide. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 4 diseases for CORIN:    
    About MalaCards
    preeclampsia/eclampsia 5    cone-rod dystrophy 18    scimitar syndrome    eclampsia

    2 diseases from the University of Copenhagen DISEASES database for CORIN:
    Scimitar syndrome     Prostate cancer

    Find genes that share disorders with CORIN           About GenesLikeMe

    7 Novoseek inferred disease relationships for CORIN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    total anomalous pulmonary venous connection 59.5 1 11082206 (1)
    cardiac hypertrophy 54.6 5 18669922 (2), 15191894 (1), 16054020 (1)
    heart failure 39.2 2 15191894 (1), 16054020 (1)
    heart failure congestive 29.5 1 11082206 (1)
    congenital heart disease 21.6 1 11082206 (1)
    atherosclerosis 16.9 1 16216958 (1)
    cardiovascular diseases 3.19 3 17485366 (1), 16054020 (1), 11082206 (1)

    Genetic Association Database (GAD): CORIN
    Human Genome Epidemiology (HuGE) Navigator: CORIN (7 documents)

    Export disorders for CORIN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CORIN gene, integrated from 10 sources (see all 64):
    (articles sorted by number of sources associating them with CORIN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart. (PubMed id 10329693)1, 2, 3, 9 Yan W.... Wu Q. (J. Biol. Chem. 1999)
    2. Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin. (PubMed id 14559895)1, 2, 9 Knappe S.... Wu Q. (J. Biol. Chem. 2003)
    3. Role of glycosylation in corin zymogen activation. (PubMed id 17660514)1, 2, 9 Liao X.... Wu Q. (J. Biol. Chem. 2007)
    4. Localization of the mosaic transmembrane serine protease corin to heart myocytes. (PubMed id 11082206)1, 2, 9 Hooper J.D.... Antalis T.M. (Eur. J. Biochem. 2000)
    5. Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme. (PubMed id 10880574)1, 2, 9 Yan W.... Wu Q. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    6. Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension. (PubMed id 16216958)1, 4, 9 Dries D.L....Drazner M.H. (Circulation 2005)
    7. Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting. (PubMed id 19326473)1, 4, 9 Fox A.A....Body S.C. (Anesthesiology 2009)
    8. Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy. (PubMed id 22437503)1, 2 Cui Y....Wu Q. (Nature 2012)
    9. Human corin isoforms with different cytoplasmic tails that alter cell surface targeting. (PubMed id 21518754)1, 2 Qi X.... Wu Q. (J. Biol. Chem. 2011)
    10. Ectodomain shedding and autocleavage of the cardiac membrane protease corin. (PubMed id 21288900)1, 2 Jiang J.... Wu Q. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10699 HGNC: 19012 AceView: CORINandHOZFP Ensembl:ENSG00000145244 euGenes: HUgn10699
    ECgene: CORIN H-InvDB: CORIN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CORIN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CORIN gene:
    Search GeneIP for patents involving CORIN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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