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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CORIN Gene

protein-coding   GIFtS: 59
GCID: GC04M047596

corin, serine peptidase

(Previous names: corin, serine protease )
 Explore 11 diseases affiliated with
CORIN via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CORIN    

Aliases
for CORIN gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Corin, Serine Peptidase1 2     PRSC1
CRN1 2 3 5     Corin, Serine Protease1
TMPRSS101 2 3     PEE52
ATC21 2     Atrial Natriuretic Peptide-Converting Enzyme2
Lrp41 2     Pro-ANP-Convertase1
Heart-Specific Serine Proteinase ATC22 3     Corin3
Pro-ANP-Converting Enzyme2 3     EC 3.4.21.-3
Transmembrane Protease Serine 102 3     EC 3.4.218

External Ids:    HGNC: 190121   Entrez Gene: 106992   Ensembl: ENSG000001452447   OMIM: 6052365   UniProtKB: Q9Y5Q53   

Export aliases for CORIN gene to outside databases

Previous GC identifers: GC04M047512 GC04M047436 GC04M047290 GC04M046915


Summaries
for CORIN gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CORIN:
This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of
this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial
natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume
and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: CORIN_HUMAN, Q9Y5Q5
Function: Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through
proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in
heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in
female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of
sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide
Function: Isoform 2: has weaker endopeptidase activity compared to isoform 1

Gene Wiki entry for CORIN


Genomic Views
for CORIN gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006238.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CORIN gene promoter:
         AML1a   POU2F1   HSF2   POU2F1a   MIF-1   Nkx2-5   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CORIN promoter sequence
   Search SABiosciences Chromatin IP Primers for CORIN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CORIN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p13-p12   Ensembl cytogenetic band:  4p12   HGNC cytogenetic band: 4p13-p12

CORIN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CORIN gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M047596:  view genomic region     (about GC identifiers)

Start:
 47,596,015 bp from pter      End:
 47,840,123 bp from pter
Size:
 244,109 bases      Orientation:
 minus strand

Proteins
for CORIN gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CORIN_HUMAN, Q9Y5Q5 (See protein sequence)
Recommended Name: Atrial natriuretic peptide-converting enzyme  
Size: 1042 amino acids; 116486 Da
Subcellular location: Cell membrane; Single-pass type II membrane protein. Note=May easily detached from the
endothelial cell membrane
Subcellular location: Isoform 2: Cell membrane; Single-pass type II membrane protein. Note=Less efficiently targeted to
the cell membrane compared to isoform 1
Subcellular location: Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment: Secreted. Note=Soluble
form produced following cleavage by ADAM10
Subcellular location: Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment: Secreted. Note=Soluble
form produced following autocatalytic cleavage
Subcellular location: Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment: Secreted. Note=Soluble
form produced following autocatalytic cleavage
Miscellaneous: Initially named CORIN due to its abundant expression in the heart (PubMed:10329693)
Secondary accessions: B0ZBE3 Q2TBD2 Q4W5E5 Q4W5G6 Q9UHY2
Alternative splicing: 2 isoforms:  Q9Y5Q5-1   Q9Y5Q5-2   

Explore the universe of human proteins at neXtProt for CORIN: NX_Q9Y5Q5

Post-translational modifications:

  • N-glycosylated; required for processing and activation1
  • Activated through proteolytic processing by a trypsin-like protease; cleaved into a N-terminal propeptide and an
    • activated corin protease fragment. Different soluble forms are produced by cleavage and autocatalytic cleavage: Atrial
    natriuretic peptide-converting enzyme, 180 kDa soluble fragment is produced by cleavage by ADAM10, while 160 kDa and
    100 kDa soluble fragments are produced by autocatalytic cleavage. Cleavage by ADAM10 to produce soluble 180 kDa
    soluble fragment takes place after the transmembrane region and before FZ 11
  • A disulfide bond links the activated corin protease fragment and the N-terminal propeptide. The disulfide bond also
    • links the activated corin protease fragment with soluble fragments (100 kDa, 160 kDa and 180 kDa fragments)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y5Q5

    • 3 DME Specific Peptides for CORIN (Q9Y5Q5)
     CYITGWG  GDSGGPL  SGGPLVC 

    CORIN Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006578.2  
    ENSEMBL proteins: 
     ENSP00000273857   ENSP00000425597   ENSP00000424212   ENSP00000425401   ENSP00000423216  

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    Novus Biologicals CORIN Protein
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CORIN

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane IEA--
    GO:0005887integral to plasma membrane IDA--
    GO:0009986cell surface IEA--
    GO:0016020membrane ----


    CORIN for ontologies           About GeneDecksing



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    Uscn Antibodies for CORIN
    Search ThermoFisher Antibodies for CORIN

    Assay Products for CORIN: 
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    Uscn ELISAs and CLIAs for CORIN

    Protein Domains /
    Families
    for CORIN gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CORIN for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR017052 Peptidase_S1A_corin
     IPR023415 LDLR_class-A_CS
     IPR020067 Frizzled_dom
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry Q9Y5Q5

    ProtoNet protein and cluster: Q9Y5Q5

    3 Blocks protein families:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature
    IPB002172 Low density lipoprotein-receptor


    UniProtKB/Swiss-Prot: CORIN_HUMAN, Q9Y5Q5
    Domain: The DDNN motif is required for targeting to the cell membrane and enzyme activation (PubMed:21518754)
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 2 FZ (frizzled) domains
    Similarity: Contains 7 LDL-receptor class A domains
    Similarity: Contains 1 peptidase S1 domain
    Similarity: Contains 1 SRCR domain


    Function
    for CORIN gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CORIN_HUMAN, Q9Y5Q5
    Function: Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through
    proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in
    heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in
    female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of
    sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide
    Function: Isoform 2: has weaker endopeptidase activity compared to isoform 1
    Enzyme regulation: Inhibited in a dose-dependent manner by non-specific trypsin-like serine protease inhibitors
    including benzamidine
    Biophysicochemical properties: Kinetic parameters: KM=1.28 mM for pyroGlu-Phe-Lys-pNA.HCl; KM=3.52 mM for
    pyroGlu-Pro-Arg-pNA.HCl; KM=2.95 mM for H-D-Pro-Phe-Arg-pNA.2HCl; KM=1.92 mM for
    Bz-Ile-Glu-(gamma-OR)-Gly-Arg-pNA.HCl; KM=16 mM for pyroGlu-Gly-Arg-pNA.HCl;

         Genatlas biochemistry entry for CORIN:
    corin,transmembrane serine protease,expressed only in the heart in the primary atrial septum and the trabecular
    ventricular compartment

    Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.-1

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CORIN
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate CORIN (see all 31):
    hsa-miR-1287 hsa-miR-34b* hsa-miR-3673 hsa-miR-520e hsa-miR-302d hsa-miR-485-3p hsa-miR-302e hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CORIN 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CORIN (see all 7)
    OriGene shRNA RFP: CORIN
    OriGene siRNA: CORIN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CORIN

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CORIN (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CORIN (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CORIN (NM_006587)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CORIN 

    Cell Line
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    Search LifeMap BioReagents cell lines for CORIN

    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004252serine-type endopeptidase activity IDA--
    GO:0005044scavenger receptor activity IEA--
    GO:0070008serine-type exopeptidase activity IEA--


    CORIN for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for CORIN:
     Increased Salmonella enterica   Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Corintm1Qwu for CORIN
         8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Corin):
     cardiovascular system  cellular  growth/size  homeostasis/metabolism  integument 
     muscle  pigmentation  renal/urinary system 

    CORIN for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CORIN gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Calcium Regulation in the Cardiac Cell
    		Myometrial Relaxation and Contraction Pathways0.43


    1 BioSystems Pathway for CORIN 
        Myometrial Relaxation and Contraction Pathways


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CORIN

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CORIN (ENSP000002738574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC1ENSP000003626494STRING: ENSP00000362649
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003050regulation of systemic arterial blood pressure by atrial natriuretic peptide ISS--
    GO:0006508proteolysis IEA--
    GO:0007565female pregnancy IMP--
    GO:0008217regulation of blood pressure ISS--
    GO:0016486peptide hormone processing IDA10880574


    CORIN for ontologies           About GeneDecksing



    Drugs & Compounds
    for CORIN gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CORIN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CORIN
    1 Novoseek chemical compound relationship for CORIN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 62.9 19 10880574 (2), 17485366 (2), 12154094 (1), 15192093 (1) (see all 14)

    Search CenterWatch for drugs/clinical trials and news about CORIN 

    Transcripts
    for CORIN gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CORIN gene: 
    NM_006587.2  

    Unigene Cluster for CORIN:

    Corin, serine peptidase
    Hs.518618  [show with all ESTs]
    Unigene Representative Sequence: BX648285
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273857(uc011bzf.2 uc003gxm.3 uc011bzg.2) ENST00000508498
    ENST00000502252 ENST00000505909 ENST00000515827 ENST00000505754 ENST00000504584(uc011bzh.1)
    ENST00000503821(uc011bzi.1) ENST00000502726(uc003gxn.4) ENST00000510974


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CORIN
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate CORIN (see all 31):
    hsa-miR-1287 hsa-miR-34b* hsa-miR-3673 hsa-miR-520e hsa-miR-302d hsa-miR-485-3p hsa-miR-302e hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CORIN 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CORIN (see all 7)
    OriGene shRNA RFP: CORIN
    OriGene siRNA: CORIN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CORIN
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CORIN (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CORIN (NM_006587)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CORIN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CORIN

    Additional cDNA sequence: 

    AF113248.1 AF133845.1 AK297675.1 AK302816.1 AK304038.1 AK304466.1 BC110451.2 BX648285.1 

    5 DOTS entries:

    DT.309431  DT.101970734  DT.307667  DT.92420689  DT.102839486 

    24/102 AceView cDNA sequences (see all 102):

    AI354875 BF221651 BM466645 AA908176 AK131285 BF971191 AI700455 AA906367 
    AI890823 BM781738 AI420051 BM468006 AF133845 AI625201 AL697900 BC040151 
    BG773458 AA046682 NM_006587 BU620685 BF108827 BM724120 BU156234 BG742247 

    GeneLoc Exon Structure


    Expression
    for CORIN gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CORIN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTGTTTTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CORIN expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Floor PlateFloor Plate Cells Neural Ectoderm
    BoneZeugopod Growth PlateBone
    BrainMedulla OblongataBrain
    Neural TubeMesencephalic Floor PlateNeural Tube
    Neural TubeMetencephalonNeural Tube
    Spinal CordSpinal Floor PlateSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    ES-J1 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Otx2-GFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    Neuronal progenitor cells (Derivation of functi...)
    Otx2+Corin+ cells (Derivation of functi...)
    HyStem+BMP4-induced SK11 cells (HyStem+BMP4 inductio...)Bone, Cartilage

    See CORIN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CORIN

    SOURCE GeneReport for Unigene cluster: Hs.518618

    UniProtKB/Swiss-Prot: CORIN_HUMAN, Q9Y5Q5
    Tissue specificity: Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus. Detected
    in blood, in plasma as well as in serum (at protein level)

        SABiosciences Custom PCR Arrays for CORIN
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CORIN
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CORIN
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORIN

    Orthologs
    for CORIN gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CORIN gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC1008577331 atrial natriuretic peptide-converting enzyme-like 75.48(n)
    77.56(a)    		   100857733  XM_003641209.1  XP_003641257.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CORIN6
    --
    		 --
    		 79(a)
    58(a)
    		 1 ↔ many
    1 ↔ many
    		 GL343293.1(365038-412572)
    GL343293.1(417279-466644)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5591091 novel protein similar to H.sapiens CORIN, corin, serine more 67.5(n)
    65.36(a)    		   559109  XM_003201242.1  XP_003201290.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea try-16
    		 TRYpsin-like Protease family member (try-1)
    		 29(a)
    		 1 → many
    		 II(4948148-4949480)


    ENSEMBL Gene Tree for CORIN (if available)
    TreeFam Gene Tree for CORIN (if available) 

    Paralogs
    for CORIN gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CORIN gene
    CFI2  
    18/68 SIMAP similar genes for CORIN using alignment to 5 protein entries:     CORIN_HUMAN (see all proteins) (see all similar genes):
    F12    DKFZp586F0824    PRSS45    PRSS46    TMPRSS11B    CTRL
    PRSS41    TMPRSS11D    CTRC    CTRB1    GZMM    TRY6
    CELA2B    CELA1    CTRB2    FRZB    PRSS42    TMPRSS2

    CORIN for paralogs           About GeneDecksing



    Genomic Variants
    for CORIN gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for CORIN
         3 CNVs: 63817 4392 92078
         1 Indel: 92079
    Human Gene Mutation Database (HGMD): CORIN
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CORIN
    DNA2.0 Custom Variant and Variant Library Synthesis for CORIN

    Disorders / Diseases
    for CORIN gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CORIN for disorders           About GeneDecksing

    OMIM gene information: 605236    OMIM disorders: --

    UniProtKB/Swiss-Prot: CORIN_HUMAN, Q9Y5Q5
  • Defects in CORIN are the cause of pre-eclampsia/eclampsia 5 (PEE5) [MIM:614595]; also known as gestational
    • proteinuric hypertension. Preeclampsia is a pregnancy-associated disease with maternal symptoms but placental origin.
    Unlike most other human disorders, it impacts 2 individuals, the mother and her child, both of whom can be severely
    affected

    11 diseases for CORIN:    About MalaCards
    high blood pressure    aortic valve stenosis    systolic heart failure    scimitar syndrome
    hearing loss    chagas disease    kidney disease    gout
    lung cancer    hypertension    schizophrenia

    2 diseases from the University of Copenhagen DISEASES database for CORIN:
    Scimitar syndrome     Prostate cancer

    7 Novoseek disease relationships for CORIN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    total anomalous pulmonary venous connection 59.5 1 11082206 (1)
    cardiac hypertrophy 54.6 5 18669922 (2), 15191894 (1), 16054020 (1)
    heart failure 39.2 2 15191894 (1), 16054020 (1)
    heart failure congestive 29.5 1 11082206 (1)
    congenital heart disease 21.6 1 11082206 (1)
    atherosclerosis 16.9 1 16216958 (1)
    cardiovascular diseases 3.19 3 17485366 (1), 16054020 (1), 11082206 (1)

    Genetic Association Database (GAD): CORIN
    Human Genome Epidemiology (HuGE) Navigator: CORIN (7 documents)

    Export disorders for CORIN gene to outside databases

    Publications
    for CORIN gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CORIN gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with CORIN)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart. (PubMed id 10329693)1, 2, 3, 9 Yan W.... Wu Q. (1999)
    2. Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin. (PubMed id 14559895)1, 2, 9 Knappe S.... Wu Q. (2003)
    3. Role of glycosylation in corin zymogen activation. (PubMed id 17660514)1, 2, 9 Liao X.... Wu Q. (2007)
    4. Localization of the mosaic transmembrane serine protease corin to heart myocytes. (PubMed id 11082206)1, 2, 9 Hooper J.D.... Antalis T.M. (2000)
    5. Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme. (PubMed id 10880574)1, 2, 9 Yan W.... Wu Q. (2000)
    6. Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension. (PubMed id 16216958)1, 4, 9 Dries D.L....Drazner M.H. (2005)
    7. Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy. (PubMed id 22437503)1, 2 Cui Y....Wu Q. (2012)
    8. Human corin isoforms with different cytoplasmic tails that alter cell surface targeting. (PubMed id 21518754)1, 2 Qi X....Wu Q. (2011)
    9. Ectodomain shedding and autocleavage of the cardiac m embrane protease corin. (PubMed id 21288900)1, 2 Jiang J....Wu Q. (2011)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for CORIN gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CORIN gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10699 HGNC: 19012 AceView: CORINandHOZFP Ensembl:ENSG00000145244 euGenes: HUgn10699
    ECgene: CORIN H-InvDB: CORIN

    Other Databases showing CORIN gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CORIN gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CORIN Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CORIN gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CORIN gene:
    Search GeneIP for patents involving CORIN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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