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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CORIN Gene

protein-coding   GIFtS: 58
GCID: GC04M047596

Corin, Serine Peptidase

(Previous names: corin, serine protease)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Corin, Serine Peptidase1 2     Lrp42
CRN2 3 5     PEE52
Heart-Specific Serine Proteinase ATC22 3     Atrial Natriuretic Peptide-Converting Enzyme2
Pro-ANP-Converting Enzyme2 3     pro-ANP-convertase2
Transmembrane Protease Serine 102 3     Corin3
TMPRSS102 3     EC 3.4.21.-3
Corin, Serine Protease1     EC 3.4.218
ATC22     

External Ids:    HGNC: 190121   Entrez Gene: 106992   Ensembl: ENSG000001452447   OMIM: 6052365   UniProtKB: Q9Y5Q53   

Export aliases for CORIN gene to outside databases

Previous GC identifers: GC04M047512 GC04M047436 GC04M047290 GC04M046915


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CORIN Gene:
This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members
of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial
natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood
volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple
alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jun 2013)

GeneCards Summary for CORIN Gene: 
CORIN (corin, serine peptidase) is a protein-coding gene. Diseases associated with CORIN include pre-eclampsia/eclampsia 5, and scimitar syndrome, and among its related super-pathways are Calcium Regulation in the Cardiac Cell. GO annotations related to this gene include serine-type exopeptidase activity and serine-type endopeptidase activity. An important paralog of this gene is CFI.

UniProtKB/Swiss-Prot: CORIN_HUMAN, Q9Y5Q5
Function: Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts
through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood
pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also
plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also
acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide
Function: Isoform 2: has weaker endopeptidase activity compared to isoform 1

Gene Wiki entry for CORIN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_006238.11  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CORIN gene promoter:
         AML1a   POU2F1   HSF2   POU2F1a   MIF-1   Nkx2-5   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCORIN promoter sequence
   Search SABiosciences Chromatin IP Primers for CORIN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CORIN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p13-p12   Ensembl cytogenetic band:  4p12   HGNC cytogenetic band: 4p13-p12

CORIN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CORIN gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M047596:  view genomic region     (about GC identifiers)

Start:
47,596,015 bp from pter      End:
47,840,123 bp from pter
Size:
244,109 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CORIN_HUMAN, Q9Y5Q5 (See protein sequence)
Recommended Name: Atrial natriuretic peptide-converting enzyme  
Size: 1042 amino acids; 116486 Da
Subcellular location: Cell membrane; Single-pass type II membrane protein. Note=May easily detached from the
endothelial cell membrane
Subcellular location: Isoform 2: Cell membrane; Single-pass type II membrane protein. Note=Less efficiently
targeted to the cell membrane compared to isoform 1
Subcellular location: Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment: Secreted.
Note=Soluble form produced following cleavage by ADAM10
Subcellular location: Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment: Secreted.
Note=Soluble form produced following autocatalytic cleavage
Subcellular location: Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment: Secreted.
Note=Soluble form produced following autocatalytic cleavage
Miscellaneous: Initially named CORIN due to its abundant expression in the heart (PubMed:10329693)
Secondary accessions: B0ZBE3 Q2TBD2 Q4W5E5 Q4W5G6 Q9UHY2
Alternative splicing: 2 isoforms:  Q9Y5Q5-1   Q9Y5Q5-2   

Explore the universe of human proteins at neXtProt for CORIN: NX_Q9Y5Q5

Explore proteomics data for CORIN at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated; required for processing and activation
  • UniProtKB: Activated through proteolytic processing by a trypsin-like protease; cleaved into a N-terminal propeptide and an
    activated corin protease fragment. Different soluble forms are produced by cleavage and autocatalytic cleavage:
    Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment is produced by cleavage by ADAM10, while
    160 kDa and 100 kDa soluble fragments are produced by autocatalytic cleavage. Cleavage by ADAM10 to produce
    soluble 180 kDa soluble fragment takes place after the transmembrane region and before FZ 1
  • UniProtKB: A disulfide bond links the activated corin protease fragment and the N-terminal propeptide. The disulfide bond
    also links the activated corin protease fragment with soluble fragments (100 kDa, 160 kDa and 180 kDa fragments)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y5Q5

  • 3 DME Specific Peptides for CORIN (Q9Y5Q5)
     CYITGWG  GDSGGPL  SGGPLVC 

    CORIN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CORIN Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001265514.1  NP_001265515.1  NP_006578.2  

    ENSEMBL proteins: 
     ENSP00000273857   ENSP00000425597   ENSP00000424212   ENSP00000425401   ENSP00000423216  

    Human Recombinant Protein Products for CORIN: 
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    Browse OriGene Protein Over-expression Lysates
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    Novus Biologicals CORIN Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane IEA--
    GO:0005887integral to plasma membrane IDA--
    GO:0009986cell surface IEA--
    GO:0016020membrane ----

    CORIN for ontologies           About GeneDecksing



    CORIN Antibody Products: 
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    Novus Biologicals CORIN Antibodies
    Abcam antibodies for CORIN
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for CORIN
    LSBio Antibodies in human, mouse, rat for CORIN 

    Assay Products for CORIN: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for CORIN
    GenScript Custom Assay Services for CORIN
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TMPRSS: Serine peptidases / Transmembrane

    5/8 InterPro protein domains (see all 8):
     IPR017052 Peptidase_S1A_corin
     IPR023415 LDLR_class-A_CS
     IPR020067 Frizzled_dom
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS

    Graphical View of Domain Structure for InterPro Entry Q9Y5Q5

    ProtoNet protein and cluster: Q9Y5Q5

    3 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature
    IPB002172 Low density lipoprotein-receptor


    UniProtKB/Swiss-Prot: CORIN_HUMAN, Q9Y5Q5
    Domain: The DDNN motif is required for targeting to the cell membrane and enzyme activation (PubMed:21518754)
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 2 FZ (frizzled) domains
    Similarity: Contains 7 LDL-receptor class A domains
    Similarity: Contains 1 peptidase S1 domain
    Similarity: Contains 1 SRCR domain


    CORIN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CORIN_HUMAN, Q9Y5Q5
    Function: Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts
    through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood
    pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also
    plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also
    acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide
    Function: Isoform 2: has weaker endopeptidase activity compared to isoform 1
    Enzyme regulation: Inhibited in a dose-dependent manner by non-specific trypsin-like serine protease inhibitors
    including benzamidine
    Biophysicochemical properties: Kinetic parameters: KM=1.28 mM for pyroGlu-Phe-Lys-pNA.HCl; KM=3.52 mM for
    pyroGlu-Pro-Arg-pNA.HCl; KM=2.95 mM for H-D-Pro-Phe-Arg-pNA.2HCl; KM=1.92 mM for
    Bz-Ile-Glu-(gamma-OR)-Gly-Arg-pNA.HCl; KM=16 mM for pyroGlu-Gly-Arg-pNA.HCl;

         Genatlas biochemistry entry for CORIN:
    corin,transmembrane serine protease,expressed only in the heart in the primary atrial septum and the trabecular
    ventricular compartment

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.-1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IDA10880574
    GO:0005044scavenger receptor activity IEA--
    GO:0005515protein binding ----
    GO:0070008serine-type exopeptidase activity IEA--
         
    CORIN for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CORIN:
     Increased Salmonella enterica   Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Corin):
     cardiovascular system  cellular  growth/size  homeostasis/metabolism  integument 
     muscle  pigmentation  renal/urinary system 

    CORIN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Corintm1Qwu for CORIN

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CORIN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CORIN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CORIN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CORIN 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CORIN
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate CORIN (see all 31):
    hsa-miR-1287 hsa-miR-34b* hsa-miR-3673 hsa-miR-520e hsa-miR-302d hsa-miR-485-3p hsa-miR-302e hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmidCORIN 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CORIN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CORIN

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CORIN

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CORIN (see all 9)
    OriGene ORF clones in mouse, rat for CORIN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CORIN (NM_006587)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CORIN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CORIN
    Sirion Biotech Customized lentivirus for stable overexpression of CORIN 
                         Customized lentivirus expression plasmids for stable overexpression of CORIN 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CORIN
    Search LifeMap BioReagents cell lines for CORIN
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORIN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CORIN About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Calcium Regulation in the Cardiac Cell
    Myometrial Relaxation and Contraction Pathways0.43


    1 BioSystems Pathway for CORIN
        Myometrial Relaxation and Contraction Pathways


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CORIN

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CORIN (ENSP000002738574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC1ENSP000003626494STRING: ENSP00000362649
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003050regulation of systemic arterial blood pressure by atrial natriuretic peptide ISS--
    GO:0006508proteolysis IEA--
    GO:0007565female pregnancy IMP--
    GO:0008217regulation of blood pressure ISS--
    GO:0016486peptide hormone processing IDA10880574

    CORIN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CORIN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CORIN

    1 Novoseek inferred chemical compound relationship for CORIN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 62.9 19 10880574 (2), 17485366 (2), 12154094 (1), 15192093 (1) (see all 14)

    Search CenterWatch for drugs/clinical trials and news about CORIN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CORIN gene (3 alternative transcripts): 
    NM_001278585.1  NM_001278586.1  NM_006587.3  

    Unigene Cluster for CORIN:

    Corin, serine peptidase
    Hs.518618  [show with all ESTs]
    Unigene Representative Sequence: BX648285
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273857(uc011bzf.2 uc003gxm.3 uc011bzg.2) ENST00000508498
    ENST00000502252 ENST00000505909 ENST00000515827 ENST00000505754 ENST00000504584(uc011bzh.1)
    ENST00000503821(uc011bzi.1) ENST00000502726(uc003gxn.4) ENST00000510974

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CORIN
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate CORIN (see all 31):
    hsa-miR-1287 hsa-miR-34b* hsa-miR-3673 hsa-miR-520e hsa-miR-302d hsa-miR-485-3p hsa-miR-302e hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmidCORIN 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene RNAi products in human, mouse, rat for CORIN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CORIN
    Clone
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    OriGene ORF clones in mouse, rat for CORIN
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    GenScript: all cDNA clones in your preferred vector: CORIN (NM_006587)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CORIN
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CORIN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CORIN

    Additional mRNA sequence: 

    AF113248.1 AF133845.1 AK297675.1 AK302816.1 AK304038.1 AK304466.1 BC110451.2 BX648285.1 

    5 DOTS entries:

    DT.309431  DT.101970734  DT.307667  DT.92420689  DT.102839486 

    24/102 AceView cDNA sequences (see all 102):

    BU620685 NM_006587 BG773458 BC040151 AL697900 AA046682 AI625201 BF221651 
    BM468006 AF133845 BM466645 BM781738 AA908176 AK131285 BF971191 AA906367 
    AI700455 AI890823 AI420051 AI354875 BF108827 AY134856 BF977748 BQ022433 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CORIN expression in normal human tissues (normalized intensities)      CORIN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGTTTTGG
    CORIN Expression
    About this image


    CORIN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Early Floor Plate Cells Mesencephalic Floor Plate
             Metencephalon
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Cardiomyocyte-like progenitor cells ( Derivation of cardiomyocytes from pluripotent...
             atrial myocardium   
     
     Dermis (Integumentary System)    fully expand to see all 3 entries
             Guard Dermal Papilla Cells Dermal Papilla
             Human Hair Outer Root Sheath Cells (HHORSC)   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Early Floor Plate Cells Mesencephalic Floor Plate
             Medulla Oblongata
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Growth Plate
             HyStem+BMP4-induced SK11 cells

    See CORIN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CORIN

    SOURCE GeneReport for Unigene cluster: Hs.518618

    UniProtKB/Swiss-Prot: CORIN_HUMAN, Q9Y5Q5
    Tissue specificity: Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus.
    Detected in blood, in plasma as well as in serum (at protein level)

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CORIN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CORIN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CORIN gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Corin1 , 5 corin1, 5 83.63(n)1
    83.43(a)1
      5 (38.44 cM)5
    534191  NM_016869.31  NP_058565.21 
     723000255 
    chicken
    (Gallus gallus)
    Aves LOC1008577331 atrial natriuretic peptide-converting enzyme-like 75.48(n)
    77.56(a)
      100857733  XM_003641209.1  XP_003641257.1 
    lizard
    (Anolis carolinensis)
    Reptilia CORIN6
    corin, serine peptidase
    70(a)
    1 ↔ 1
    GL343293.1(365038-504289)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5591091 novel protein similar to H.sapiens CORIN, corin, serine more 67.5(n)
    65.36(a)
      559109  XM_003201242.1  XP_003201290.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG342906
    --
    23(a)
    1 ↔ 1
    3R(20114275-20115540)


    ENSEMBL Gene Tree for CORIN (if available)
    TreeFam Gene Tree for CORIN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CORIN gene
    CFI2  PRSS562  ACR2  TMPRSS122  
    18/64 SIMAP similar genes for CORIN using alignment to 5 protein entries:     CORIN_HUMAN (see all proteins) (see all similar genes):
    F12    DKFZp586F0824    PRSS45    PRSS46    TMPRSS11B    CTRL
    PRSS41    TMPRSS11D    CTRC    CTRB1    GZMM    TRY6
    CELA2B    CELA1    CTRB2    FRZB    PRSS42    TMPRSS2

    CORIN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4699 SNPs in CORIN are shown (see all 4699)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0677974
    Pre-eclampsia/eclampsia 5 (PEE5)4--see VAR_0677972 S G mis40--------
    VAR_0677954
    Pre-eclampsia/eclampsia 5 (PEE5)4--see VAR_0677952 K E mis40--------
    rs355314031,2
    C--46944619(+) TAACC-/CTCTCT
    /CTCTCTCT
    TCTCT
    2 -- int1 cds10--------
    rs1114305601,2
    C,F--47074731(+) GTGTAC/TGAACA 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1867909281,2
    --47093628(+) GATAGA/GTAGAT 1 -- int10--------
    rs1469676331,2
    --47093636(+) GATAGA/GTAGGT 1 -- int10--------
    rs1492761091,2
    --47138368(+) ACGTG-/CACACAC 1 -- int10--------
    rs1394396781,2
    C--47138369(+) ACGTG-/CACA  
            
    CACAC
    1 -- int10--------
    rs1130245981,2
    C--47138379(+) ACACAG/CACACA 1 -- int11Minor allele frequency- C:0.50WA 2
    rs100055061,2
    C,F,H--47475461(+) TTAAAG/AGGTCA 1 -- ds50019Minor allele frequency- A:0.05NS EA NA WA 1208

    HapMap Linkage Disequilibrium report for CORIN (47596015 - 47840123 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CORIN:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2660213CNV Deletion23128226
    esv2727531CNV Deletion23290073
    nsv822557CNV Loss20364138
    nsv879007CNV Loss21882294
    nsv4328CNV Loss18451855
    esv27666CNV Loss19812545
    nsv829923CNV Gain17160897
    nsv829924CNV Gain17160897


    Human Gene Mutation Database (HGMD): CORIN
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CORIN
    DNA2.0 Custom Variant and Variant Library Synthesis for CORIN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605236    OMIM disorders: --

    UniProtKB/Swiss-Prot: CORIN_HUMAN, Q9Y5Q5
  • Pre-eclampsia/eclampsia 5 (PEE5) [MIM:614595]: A hypertensive disorder of pregnancy characterized by new
    hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant
    proteinuria. It impacts 2 individuals, the mother and her child, both of whom can be severely affected.
    Preeclampsia is one of the causes of maternal mortality and morbidity worldwide. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 14 diseases for CORIN:    About MalaCards
    pre-eclampsia/eclampsia 5    scimitar syndrome    systolic heart failure    aortic valve stenosis
    chagas disease    gout    pre-eclampsia    eclampsia
    kidney disease    hypertension    atherosclerosis    schizophrenia
    lung cancer    endotheliitis

    2 diseases from the University of Copenhagen DISEASES database for CORIN:
    Scimitar syndrome     Prostate cancer

    CORIN for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for CORIN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    total anomalous pulmonary venous connection 59.5 1 11082206 (1)
    cardiac hypertrophy 54.6 5 18669922 (2), 15191894 (1), 16054020 (1)
    heart failure 39.2 2 15191894 (1), 16054020 (1)
    heart failure congestive 29.5 1 11082206 (1)
    congenital heart disease 21.6 1 11082206 (1)
    atherosclerosis 16.9 1 16216958 (1)
    cardiovascular diseases 3.19 3 17485366 (1), 16054020 (1), 11082206 (1)

    Genetic Association Database (GAD): CORIN
    Human Genome Epidemiology (HuGE) Navigator: CORIN (7 documents)

    Export disorders for CORIN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CORIN gene, integrated from 9 sources (see all 62):
    (articles sorted by number of sources associating them with CORIN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart. (PubMed id 10329693)1, 2, 3, 9 Yan W.... Wu Q. (1999)
    2. Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin. (PubMed id 14559895)1, 2, 9 Knappe S.... Wu Q. (2003)
    3. Role of glycosylation in corin zymogen activation. (PubMed id 17660514)1, 2, 9 Liao X.... Wu Q. (2007)
    4. Localization of the mosaic transmembrane serine protease corin to heart myocytes. (PubMed id 11082206)1, 2, 9 Hooper J.D.... Antalis T.M. (2000)
    5. Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme. (PubMed id 10880574)1, 2, 9 Yan W.... Wu Q. (2000)
    6. Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension. (PubMed id 16216958)1, 4, 9 Dries D.L....Drazner M.H. (2005)
    7. Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting. (PubMed id 19326473)1, 4, 9 Fox A.A....Body S.C. (2009)
    8. Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy. (PubMed id 22437503)1, 2 Cui Y....Wu Q. (2012)
    9. Human corin isoforms with different cytoplasmic tails that alter cell surface targeting. (PubMed id 21518754)1, 2 Qi X....Wu Q. (2011)
    10. Ectodomain shedding and autocleavage of the cardiac m embrane protease corin. (PubMed id 21288900)1, 2 Jiang J....Wu Q. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10699 HGNC: 19012 AceView: CORINandHOZFP Ensembl:ENSG00000145244 euGenes: HUgn10699
    ECgene: CORIN H-InvDB: CORIN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CORIN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CORIN gene:
    Search GeneIP for patents involving CORIN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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