Aliases for CORIN Gene
External Ids for CORIN Gene
Previous GeneCards Identifiers for CORIN Gene
This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
GeneCards Summary for CORIN Gene
CORIN (Corin, Serine Peptidase) is a Protein Coding gene. Diseases associated with CORIN include Preeclampsia/Eclampsia 5 and Systolic Heart Failure. Among its related pathways are Myometrial Relaxation and Contraction Pathways and Cardiac conduction. GO annotations related to this gene include serine-type endopeptidase activity and serine-type exopeptidase activity. An important paralog of this gene is ST14.
UniProtKB/Swiss-Prot for CORIN Gene
Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide.
Isoform 2: has weaker endopeptidase activity compared to isoform 1.