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COQ7 Gene

protein-coding   GIFtS: 64
GCID: GC16P019078

Coenzyme Q7 Homolog, Ubiquinone (Yeast)

(Previous names: coenzyme Q, 7 (rat, yeast) homolog)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coenzyme Q7 Homolog, Ubiquinone (Yeast)1 2     CAT52
Coenzyme Q Biosynthesis Protein 7 Homolog2 3     CLK-12
Timing Protein Clk-1 Homolog2 3     COQ7 Coenzyme Q, 7 Homolog Ubiquinone2
CLK12 5     Placental Protein KG-202
Coenzyme Q, 7 (Rat, Yeast) Homolog1     Ubiquinone Biosynthesis Protein COQ7 Homolog2

External Ids:    HGNC: 22441   Entrez Gene: 102292   Ensembl: ENSG000001671867   OMIM: 6016835   UniProtKB: Q998073   

Export aliases for COQ7 gene to outside databases

Previous GC identifers: GC16P018569 GC16P019006 GC16P019045 GC16P018986 GC16P017616


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COQ7 Gene:
The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces
cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development
and longer life span. Alternatively spliced transcript variants have been found for this gene. (provided by
RefSeq, Jul 2010)

GeneCards Summary for COQ7 Gene:
COQ7 (coenzyme Q7 homolog, ubiquinone (yeast)) is a protein-coding gene. GO annotations related to this gene include oxidoreductase activity and transition metal ion binding.

UniProtKB/Swiss-Prot: COQ7_HUMAN, Q99807
Function: Involved in lifespan determination in ubiquinone-independent manner. Involved in ubiquinone
biosynthesis. Potential central metabolic regulator (By similarity)

Gene Wiki entry for COQ7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_187260.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the COQ7 gene promoter:
         SRF   p53   Pax-5   SRF (504 AA)   LUN-1   Nkx2-5   E47   AREB6   CREB   COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOQ7 promoter sequence
   Search Chromatin IP Primers for COQ7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COQ7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.3   Ensembl cytogenetic band:  16p12.3   HGNC cytogenetic band: 16p12.3

COQ7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COQ7 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P019078:  view genomic region     (about GC identifiers)

Start:
19,078,917 bp from pter      End:
19,091,417 bp from pter
Size:
12,501 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: COQ7_HUMAN, Q99807 (See protein sequence)
Recommended Name: Ubiquinone biosynthesis protein COQ7 homolog precursor  
Size: 217 amino acids; 24277 Da
Cofactor: Binds 2 iron ions per subunit (By similarity)
Subunit: Interacts with ADCK4 and COQ6
Secondary accessions: B2RDA9 Q9BTT7 Q9H0T5 Q9UEW5 Q9UNR5
Alternative splicing: 2 isoforms:  Q99807-1   Q99807-2   

Explore the universe of human proteins at neXtProt for COQ7: NX_Q99807

Explore proteomics data for COQ7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys85
  • Modification sites at PhosphoSitePlus

  • See COQ7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001177912.1  NP_057222.2  

    ENSEMBL proteins: 
     ENSP00000322316   ENSP00000456490   ENSP00000456734   ENSP00000456943   ENSP00000459076  
     ENSP00000442923   ENSP00000457256   ENSP00000455122  
    Reactome Protein details: Q99807

    COQ7 Human Recombinant Protein Products:

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    Novus Biologicals COQ7 Protein
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR012347 Ferritin-rel
     IPR011566 Ubq_synth_Coq7
     IPR009078 Ferritin-like_SF

    Graphical View of Domain Structure for InterPro Entry Q99807

    ProtoNet protein and cluster: Q99807

    2 Blocks protein domains:
    IPB004916 Ubiquinone biosyntheis protein COQ7
    IPB011566 Ubiquinone biosynthesis and related


    UniProtKB/Swiss-Prot: COQ7_HUMAN, Q99807
    Similarity: Belongs to the COQ7 family


    Find genes that share domains with COQ7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COQ7_HUMAN, Q99807
    Function: Involved in lifespan determination in ubiquinone-independent manner. Involved in ubiquinone
    biosynthesis. Potential central metabolic regulator (By similarity)

         Genatlas biochemistry entry for COQ7:
    coenzyme Q7 (rat,yeast) homolog C elegans longevity gene clk1 ortholog,expressed in heart and skeletal
    muscle,likely localized in the mitochondrial inner membrane

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with COQ7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for COQ7:
     Decreased number of cells in m 

         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Coq7):
     cellular  embryogenesis  growth/size/body  liver/biliary system  mortality/aging 
     nervous system  normal 

    Find genes that share phenotypes with COQ7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for COQ7: Coq7tm1Tsh Coq7tm1Hek

       genOway: Develop your customized and physiologically relevant rodent model for COQ7

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    Block miRNA regulation of human, mouse, rat COQ7 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate COQ7:
    hsa-miR-141 hsa-miR-495 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmidCOQ7 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COQ7_HUMAN, Q99807: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=Synthesized as
    a preprotein that is imported into the mitochondrial matrix, where the sequence is cleaved off and the mature
    protein becomes loosely associated with the inner membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus4
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane IEA--

    Find genes that share ontologies with COQ7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for COQ7 About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    2Ubiquinol biosynthesis
    Ubiquinol biosynthesis0.42
    Ubiquinone and other terpenoid-quinone biosynthesis0.42


    Find genes that share SuperPaths with COQ7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for COQ7
        Ubiquinol biosynthesis


    2 Kegg Pathways  (Kegg details for COQ7):
        Ubiquinone and other terpenoid-quinone biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: COQ7_HUMAN, Q99807
    Pathway: Cofactor biosynthesis; ubiquinone biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for COQ7
    Interactions:

        Search GeneGlobe Interaction Network for COQ7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for COQ7 (Q998073 ENSP000003223164) via UniProtKB, MINT, STRING, and/or I2D (see all 58)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206353Q154773I2D: score=1 
    ENSG00000223493Q154773I2D: score=1 
    ENSG00000225737Q154773I2D: score=1 
    ENSG00000228896Q154773I2D: score=1 
    ENSG00000232616Q154773I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001306age-dependent response to oxidative stress IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0001841neural tube formation IEA--
    GO:0006744ubiquinone biosynthetic process TAS--
    GO:0006979response to oxidative stress ----

    Find genes that share ontologies with COQ7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for COQ7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (5Z)-7-OxozeaenolPotent and selective TAK1 MAPKKK inhibitor[66018-38-0]
    GSK 650394Serum- and glucocorticoid-regulated kinase (SGK) inhibitor[890842-28-1]
    IPA 3Group I p21-activated kinase (PAK) inhibitor[42521-82-4]
    CGP 57380Selective inhibitor of Mnk1[522629-08-9]
    AZ 3146Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor[1124329-14-1]

    3 HMDB Compounds for COQ7    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone ----
    2-Hexaprenyl-3-methyl-6-methoxy-1,4 benzoquinone ----
    IronArmco iron (see all 19)7439-89-6--

    2 Novoseek inferred chemical compound relationships for COQ7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    coq7 98.6 32 8660658 (6), 10373327 (5), 10501970 (2), 17130255 (2)
    ubiquinone 83.1 4 17130255 (2), 16889924 (1), 8660658 (1)



    Find genes that share compounds with COQ7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for COQ7 gene (2 alternative transcripts): 
    NM_001190983.1  NM_016138.4  

    Unigene Cluster for COQ7:

    Coenzyme Q7 homolog, ubiquinone (yeast)
    Hs.157113  [show with all ESTs]
    Unigene Representative Sequence: NM_016138
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000321998(uc002dfr.3 uc021tee.1) ENST00000566049 ENST00000568985
    ENST00000566110 ENST00000564746 ENST00000569312 ENST00000544894 ENST00000561858
    ENST00000569127(uc002dfs.3) ENST00000567314 ENST00000569259
    miRNA
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    hsa-miR-141 hsa-miR-495 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmidCOQ7 3' UTR sequence
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    Additional mRNA sequence: 

    AF032900.1 AF098948.1 AK024291.1 AK225115.1 AK315470.1 AL136647.1 BC003185.1 U81276.1 

    5 DOTS entries:

    DT.95167674  DT.101974473  DT.75101872  DT.97820324  DT.92386860 

    Selected AceView cDNA sequences (see all 194):

    AA084125 CR621671 NM_016138 AI917815 AI805970 AI394025 AI917396 AI927474 
    H25183 BE218678 AW089926 BU736067 BM988318 AW514609 Z41194 AA434169 
    F30084 CA944525 BG152815 F13131 N45956 AA503622 AK024291 CB127222 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for COQ7 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9
    SP1:                    -     -     -     -     -           -                 -                             -     -     -         
    SP2:                    -     -     -     -     -           -                 -                                                   
    SP3:                                -     -     -           -                 -                                                   
    SP4:                    -     -     -     -     -           -     -     -     -                                                   
    SP5:                    -     -     -     -                 -                 -                                                   


    ECgene alternative splicing isoforms for COQ7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COQ7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    COQ7 Expression
    About this image

    COQ7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COQ7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.157113

    UniProtKB/Swiss-Prot: COQ7_HUMAN, Q99807
    Tissue specificity: Expressed dominantly in heart and skeletal muscle

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for COQ7 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Coq71 , 5 demethyl-Q 71, 5 81.41(n)1
    85.25(a)1
      7 (63.44 cM)5
    128501  NM_009940.21  NP_034070.11 
     1185096595 
    chicken
    (Gallus gallus)
    Aves COQ71 coenzyme Q7 homolog, ubiquinone (yeast) 68.39(n)
    73.24(a)
      416609  NM_001277172.1  NP_001264101.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.149282 Transcribed sequence with moderate similarity to protein more 75.42(n)    CF592583.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.196342 Transcribed sequence with moderate similarity to protein more 73(n)    CK019355.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta COQ71 , 3 ubiquinone metabolism3
    COQ71
    57(a)3
    59.02(n)1
    58.24(a)1
      6C133
    440071  NM_143710.21  NP_651967.21 
    worm
    (Caenorhabditis elegans)
    Secernentea clk-11 , 3 Expression: all somatic, all stages3
    clk-11
    56(a)3
    58.53(n)1
    56.4(a)1
      III(5349649-5351105)3
    1757291  NM_065727.31  NP_498128.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CAT5(YOR125C)4
    CAT51
    Protein required for ubiquinone (Coenzyme Q) biosynthesis; more4
    CAT51
    53.93(n)1
    48.31(a)1
      15(559731-559030)4
    8542921, 4  NP_014768.21, 4 


    ENSEMBL Gene Tree for COQ7 (if available)
    TreeFam Gene Tree for COQ7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COQ7 (see all 397)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs107161881,2
    C--19076947(+) TTGGA-/TTTTTT 1 -- us2k1 trp30--------
    rs1902459661,2
    --19076995(+) CTCTGC/GAGTGC 1 -- us2k10--------
    rs107161891,2
    C--19077014(+) gatca-/Tggctc 1 -- us2k10--------
    rs1129314531,2
    C,F--19077157(+) GGCTGG/CTCTTG 1 -- us2k11Minor allele frequency- C:0.50WA 2
    rs1147191901,2
    F--19077611(+) ACAGAG/ATGAAA 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1828978061,2
    --19077685(+) ATTACA/GGCAAA 2 -- us2k10--------
    rs1453617031,2
    --19077692(+) CAAAGA/GTTTTG 2 -- us2k10--------
    rs1151613351,2
    F--19077862(+) ATTCAA/GTAATT 2 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1870548081,2
    --19077870(+) ATTTTA/CCAATT 2 -- us2k10--------
    rs1914538951,2
    --19077960(+) GCTCCC/GTTCTC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for COQ7 (19078917 - 19091417 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for COQ7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436835CNV Insertion17901297
    nsv103187CNV Loss16902084
    dgv2640n71CNV Gain21882294
    esv34419CNV Gain17911159
    esv587CNV CNV17122850
    dgv823e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COQ7
    DNA2.0 Custom Variant and Variant Library Synthesis for COQ7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601683    OMIM disorders: --


    Find genes that share disorders with COQ7           About GenesLikeMe

    Genetic Association Database (GAD): COQ7
    Human Genome Epidemiology (HuGE) Navigator: COQ7 (2 documents)

    Export disorders for COQ7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COQ7 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with COQ7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1. (PubMed id 9020081)1, 2, 3 Ewbank J.J....Hekimi S. (Science 1997)
    2. Orthologues of the Caenorhabditis elegans longevity gene clk-1 in mouse and human. (PubMed id 10373327)1, 2, 9 Asaumi S.... Shirasawa T. (Genomics 1999)
    3. Conservation of the Caenorhabditis elegans timing gene clk-1 from yeast to human: a gene required for ubiquinone biosynthesis with potential implications for aging. (PubMed id 10501970)1, 2, 9 Vajo Z.... Francomano C.A. (Mamm. Genome 1999)
    4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    8. Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins. (PubMed id 10373325)1, 3 Freije J.M.P....Lopez-Otin C. (Genomics 1999)
    9. The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1. (PubMed id 18927074)1, 9 Wang Y....Hekimi S. (J. Biol. Chem. 2009)
    10. ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption. (PubMed id 24270420)2 Ashraf S....Hildebrandt F. (J. Clin. Invest. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10229 HGNC: 2244 AceView: COQ7 Ensembl:ENSG00000167186 euGenes: HUgn10229
    ECgene: COQ7 Kegg: 10229 H-InvDB: COQ7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for COQ7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for COQ7 gene:
    Search GeneIP for patents involving COQ7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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