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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COQ7 Gene

protein-coding   GIFtS: 63
GCID: GC16P019078

Coenzyme Q7 Homolog, Ubiquinone (Yeast)

(Previous names: coenzyme Q, 7 (rat, yeast) homolog)
Alzheimer's & Parkinson's Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coenzyme Q7 Homolog, Ubiquinone (Yeast)1 2     CAT52
Coenzyme Q Biosynthesis Protein 7 Homolog2 3     CLK-12
Timing Protein Clk-1 Homolog2 3     COQ7 Coenzyme Q, 7 Homolog Ubiquinone2
CLK12 5     Placental Protein KG-202
Coenzyme Q, 7 (Rat, Yeast) Homolog1     Ubiquinone Biosynthesis Protein COQ7 Homolog2

External Ids:    HGNC: 22441   Entrez Gene: 102292   Ensembl: ENSG000001671867   OMIM: 6016835   UniProtKB: Q998073   

Export aliases for COQ7 gene to outside databases

Previous GC identifers: GC16P018569 GC16P019006 GC16P019045 GC16P018986 GC16P017616


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COQ7 Gene:
The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces
cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development
and longer life span. Alternatively spliced transcript variants have been found for this gene. (provided by
RefSeq, Jul 2010)

GeneCards Summary for COQ7 Gene: 
COQ7 (coenzyme Q7 homolog, ubiquinone (yeast)) is a protein-coding gene. Diseases associated with COQ7 include hypertension, and among its related super-pathways are Metabolic pathways and Ubiquinol biosynthesis. GO annotations related to this gene include oxidoreductase activity and transition metal ion binding.

UniProtKB/Swiss-Prot: COQ7_HUMAN, Q99807
Function: Involved in lifespan determination in ubiquinone-independent manner. Involved in ubiquinone
biosynthesis. Potential central metabolic regulator (By similarity)

Gene Wiki entry for COQ7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COQ7 gene promoter:
         SRF   p53   Pax-5   SRF (504 AA)   LUN-1   Nkx2-5   E47   AREB6   CREB   COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOQ7 promoter sequence
   Search SABiosciences Chromatin IP Primers for COQ7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COQ7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.3   Ensembl cytogenetic band:  16p12.3   HGNC cytogenetic band: 16p12.3

COQ7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COQ7 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P019078:  view genomic region     (about GC identifiers)

Start:
19,078,917 bp from pter      End:
19,091,417 bp from pter
Size:
12,501 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: COQ7_HUMAN, Q99807 (See protein sequence)
Recommended Name: Ubiquinone biosynthesis protein COQ7 homolog precursor  
Size: 217 amino acids; 24277 Da
Cofactor: Binds 2 iron ions per subunit (By similarity)
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=Synthesized as
a preprotein that is imported into the mitochondrial matrix, where the sequence is cleaved off and the mature
protein becomes loosely associated with the inner membrane (By similarity)
Secondary accessions: B2RDA9 Q9BTT7 Q9H0T5 Q9UEW5 Q9UNR5
Alternative splicing: 2 isoforms:  Q99807-1   Q99807-2   

Explore the universe of human proteins at neXtProt for COQ7: NX_Q99807

Explore proteomics data for COQ7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99807

  • COQ7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    COQ7 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001177912.1  NP_057222.2  

    ENSEMBL proteins: 
     ENSP00000322316   ENSP00000456490   ENSP00000456734   ENSP00000456943   ENSP00000459076  
     ENSP00000442923   ENSP00000457256   ENSP00000455122  
    Reactome Protein details: Q99807
    Human Recombinant Protein Products for COQ7: 
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    Novus Biologicals COQ7 Protein
    Novus Biologicals COQ7 Lysate
    Sino Biological Recombinant Protein for COQ7
    Sino Biological Cell Lysate for COQ7 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for COQ7 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane IEA--

    COQ7 for ontologies           About GeneDecksing



    COQ7 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR012347 Ferritin-rel
     IPR011566 Ubq_synth_Coq7
     IPR009078 Ferritin-like_SF

    Graphical View of Domain Structure for InterPro Entry Q99807

    ProtoNet protein and cluster: Q99807

    2 Blocks protein domains:
    IPB004916 Ubiquinone biosyntheis protein COQ7
    IPB011566 Ubiquinone biosynthesis and related


    UniProtKB/Swiss-Prot: COQ7_HUMAN, Q99807
    Similarity: Belongs to the COQ7 family


    COQ7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COQ7_HUMAN, Q99807
    Function: Involved in lifespan determination in ubiquinone-independent manner. Involved in ubiquinone
    biosynthesis. Potential central metabolic regulator (By similarity)

         Genatlas biochemistry entry for COQ7:
    coenzyme Q7 (rat,yeast) homolog C elegans longevity gene clk1 ortholog,expressed in heart and skeletal
    muscle,likely localized in the mitochondrial inner membrane

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016491oxidoreductase activity IEA--
    GO:0046914transition metal ion binding IEA--
         
    COQ7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for COQ7:
     Decreased number of cells in m 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Coq7):
     cellular  embryogenesis  growth/size  mortality/aging  nervous system 

    COQ7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for COQ7: Coq7tm1Tsh Coq7tm1Hek

       inGenious Targeting Laboratory - Custom generated mouse model solutions for COQ7 
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    hsa-miR-141 hsa-miR-495 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmidCOQ7 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COQ7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for COQ7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    2Ubiquinone and other terpenoid-quinone biosynthesis
    Ubiquinol biosynthesis0.42
    Ubiquinone and other terpenoid-quinone biosynthesis0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3        Reactome Pathways for COQ7
        Metabolism
    Ubiquinol biosynthesis
    Metabolism of lipids and lipoproteins


    2         Kegg Pathways  (Kegg details for COQ7):
        Ubiquinone and other terpenoid-quinone biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: COQ7_HUMAN, Q99807
    Pathway: Cofactor biosynthesis; ubiquinone biosynthesis


    COQ7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COQ7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/46 Interacting proteins for COQ7 (Q998073 ENSP000003223164) via UniProtKB, MINT, STRING, and/or I2D (see all 46)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206353Q154773I2D: score=1 
    ENSG00000223493Q154773I2D: score=1 
    ENSG00000225737Q154773I2D: score=1 
    ENSG00000228896Q154773I2D: score=1 
    ENSG00000232616Q154773I2D: score=1 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001306age-dependent response to oxidative stress IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0001841neural tube formation IEA--
    GO:0006744ubiquinone biosynthetic process TAS--
    GO:0006979response to oxidative stress ----

    COQ7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    COQ7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for COQ7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (5Z)-7-OxozeaenolPotent and selective TAK1 MAPKKK inhibitor[66018-38-0]
    GSK 650394Serum- and glucocorticoid-regulated kinase (SGK) inhibitor[890842-28-1]
    IPA 3Group I p21-activated kinase (PAK) inhibitor[42521-82-4]
    CGP 57380Selective inhibitor of Mnk1[522629-08-9]
    AZ 3146Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor[1124329-14-1]

    3 HMDB Compounds for COQ7    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone ----
    2-Hexaprenyl-3-methyl-6-methoxy-1,4 benzoquinone ----
    IronArmco iron (see all 19)7439-89-6--

    2 Novoseek inferred chemical compound relationships for COQ7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    coq7 98.6 32 8660658 (6), 10373327 (5), 10501970 (2), 17130255 (2)
    ubiquinone 83.1 4 17130255 (2), 16889924 (1), 8660658 (1)

    Search CenterWatch for drugs/clinical trials and news about COQ7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for COQ7 gene (2 alternative transcripts): 
    NM_001190983.1  NM_016138.4  

    Unigene Cluster for COQ7:

    Coenzyme Q7 homolog, ubiquinone (yeast)
    Hs.157113  [show with all ESTs]
    Unigene Representative Sequence: NM_016138
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000321998(uc002dfr.3 uc021tee.1) ENST00000566049 ENST00000568985
    ENST00000566110 ENST00000564746 ENST00000569312 ENST00000544894 ENST00000561858
    ENST00000569127(uc002dfs.3) ENST00000567314 ENST00000569259

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate COQ7:
    hsa-miR-141 hsa-miR-495 hsa-miR-7-1* hsa-miR-7-2* hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmidCOQ7 3' UTR sequence
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    Additional mRNA sequence: 

    AF032900.1 AF098948.1 AK024291.1 AK225115.1 AK315470.1 AL136647.1 BC003185.1 U81276.1 

    5 DOTS entries:

    DT.95167674  DT.101974473  DT.75101872  DT.97820324  DT.92386860 

    24/194 AceView cDNA sequences (see all 194):

    AW514609 BM988318 AK024291 BM453996 CA944525 BU736067 AI917396 Z41194 
    N45956 AA084125 AI917815 F30084 F13131 AI394025 AI927474 BE218678 
    AW089926 BG152815 CB127222 CA945080 NM_016138 H25183 T52126 AI805970 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for COQ7 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9
    SP1:                    -     -     -     -     -           -                 -                             -     -     -         
    SP2:                    -     -     -     -     -           -                 -                                                   
    SP3:                                -     -     -           -                 -                                                   
    SP4:                    -     -     -     -     -           -     -     -     -                                                   
    SP5:                    -     -     -     -                 -                 -                                                   


    ECgene alternative splicing isoforms for COQ7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COQ7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    COQ7 Expression
    About this image


    See COQ7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COQ7

    SOURCE GeneReport for Unigene cluster: Hs.157113

    UniProtKB/Swiss-Prot: COQ7_HUMAN, Q99807
    Tissue specificity: Expressed dominantly in heart and skeletal muscle

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COQ7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for COQ7 gene from 8/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Coq71 , 5 demethyl-Q 71, 5 81.48(n)1
    85.65(a)1
      7 (63.44 cM)5
    128501  NM_009940.21  NP_034070.11 
     1185096595 
    chicken
    (Gallus gallus)
    Aves COQ71 coenzyme Q7 homolog, ubiquinone (yeast) 68.39(n)
    73.24(a)
      416609  XM_414911.3  XP_414911.1 
    lizard
    (Anolis carolinensis)
    Reptilia COQ76
    coenzyme Q7 homolog, ubiquinone (yeast)
    60(a)
    1 ↔ 1
    GL344017.1(34354-35935)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.149282 Transcribed sequence with moderate similarity to protein more 75.42(n)    CF592583.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.196342 Transcribed sequence with moderate similarity to protein more 73(n)    CK019355.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta COQ71 , 3 ubiquinone metabolism3
    CG14437-PA1
    57(a)3
    59.02(n)1
    58.24(a)1
      6C133
    440071  NM_143710.21  NP_651967.21 
    worm
    (Caenorhabditis elegans)
    Secernentea clk-11 , 3 Expression: all somatic, all stages3
    Protein CLK-11
    56(a)3
    58.53(n)1
    56.4(a)1
      III(5349649-5351105)3
    1757291  NM_065727.21  NP_498128.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CAT5(YOR125C)4
    CAT51
    Protein required for ubiquinone (Coenzyme Q) biosynthesis; more4
    Cat5p1
    53.86(n)1
    48.59(a)1
      15(559731-559030)4
    8542921, 4  NP_014768.21, 4 


    ENSEMBL Gene Tree for COQ7 (if available)
    TreeFam Gene Tree for COQ7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/397 SNPs in COQ7 are shown (see all 397)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs107161881,2
    C--19076947(+) TTGGA-/TTTTTT 1 -- us2k1 trp30--------
    rs1902459661,2
    --19076995(+) CTCTGC/GAGTGC 1 -- us2k10--------
    rs107161891,2
    C--19077014(+) gatca-/Tggctc 1 -- us2k10--------
    rs1129314531,2
    C,F--19077157(+) GGCTGG/CTCTTG 1 -- us2k11Minor allele frequency- C:0.50WA 2
    rs1147191901,2
    F--19077611(+) ACAGAG/ATGAAA 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1828978061,2
    --19077685(+) ATTACA/GGCAAA 2 -- us2k10--------
    rs1453617031,2
    --19077692(+) CAAAGA/GTTTTG 2 -- us2k10--------
    rs1151613351,2
    F--19077862(+) ATTCAA/GTAATT 2 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1870548081,2
    --19077870(+) ATTTTA/CCAATT 2 -- us2k10--------
    rs1914538951,2
    --19077960(+) GCTCCC/GTTCTC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for COQ7 (19078917 - 19091417 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for COQ7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv436835CNV Insertion17901297
    nsv103187CNV Loss16902084
    dgv2640n71CNV Gain21882294
    esv34419CNV Gain17911159
    esv587CNV CNV17122850
    dgv823e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601683    OMIM disorders: --

    2 diseases for COQ7:    About MalaCards
    hypertension    


    COQ7 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): COQ7
    Human Genome Epidemiology (HuGE) Navigator: COQ7 (2 documents)

    Export disorders for COQ7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COQ7 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with COQ7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1. (PubMed id 9020081)1, 2, 3 Ewbank J.J....Hekimi S. (1997)
    2. Orthologues of the Caenorhabditis elegans longevity gene clk-1 in mouse and human. (PubMed id 10373327)1, 2, 9 Asaumi S.... Shirasawa T. (1999)
    3. Conservation of the Caenorhabditis elegans timing gene clk-1 from yeast to human: a gene required for ubiquinone biosynthesis with potential implications for aging. (PubMed id 10501970)1, 2, 9 Vajo Z.... Francomano C.A. (1999)
    4. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    5. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    8. Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins. (PubMed id 10373325)1, 3 Freije J.M.P....Lopez-Otin C. (1999)
    9. The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1. (PubMed id 18927074)1, 9 Wang Y....Hekimi S. (2009)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10229 HGNC: 2244 AceView: COQ7 Ensembl:ENSG00000167186 euGenes: HUgn10229
    ECgene: COQ7 Kegg: 10229 H-InvDB: COQ7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COQ7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for COQ7 gene:
    Search GeneIP for patents involving COQ7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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