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Aliases for COQ7 Gene

Aliases for COQ7 Gene

  • Coenzyme Q7 Homolog, Ubiquinone (Yeast) 2 3
  • Coenzyme Q Biosynthesis Protein 7 Homolog 3 4
  • Timing Protein Clk-1 Homolog 3 4
  • CLK1 3 6
  • Ubiquinone Biosynthesis Protein COQ7 Homolog 3
  • COQ7 Coenzyme Q, 7 Homolog Ubiquinone 3
  • Coenzyme Q, 7 (Rat, Yeast) Homolog 2
  • Placental Protein KG-20 3
  • CLK-1 3
  • CAT5 3

External Ids for COQ7 Gene

Previous GeneCards Identifiers for COQ7 Gene

  • GC16P018569
  • GC16P019006
  • GC16P019045
  • GC16P018986
  • GC16P017616

Summaries for COQ7 Gene

Entrez Gene Summary for COQ7 Gene

  • The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for COQ7 Gene

COQ7 (Coenzyme Q7 Homolog, Ubiquinone (Yeast)) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include oxidoreductase activity and transition metal ion binding.

UniProtKB/Swiss-Prot for COQ7 Gene

  • Involved in lifespan determination in ubiquinone-independent manner. Involved in ubiquinone biosynthesis. Potential central metabolic regulator (By similarity).

Gene Wiki entry for COQ7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COQ7 Gene

Genomics for COQ7 Gene

Regulatory Elements for COQ7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COQ7 Gene

19,067,595 bp from pter
19,080,095 bp from pter
12,501 bases
Plus strand

Genomic View for COQ7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COQ7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COQ7 Gene

Proteins for COQ7 Gene

  • Protein details for COQ7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquinone biosynthesis protein COQ7 homolog
    Protein Accession:
    Secondary Accessions:
    • B2RDA9
    • Q9BTT7
    • Q9H0T5
    • Q9UEW5
    • Q9UNR5

    Protein attributes for COQ7 Gene

    217 amino acids
    Molecular mass:
    24277 Da
    Name=Fe cation; Xref=ChEBI:CHEBI:24875; Note=Binds 2 iron ions per subunit.;
    Quaternary structure:
    • Interacts with ADCK4 and COQ6 (PubMed:24270420). Interacts with COQ9 (PubMed:25339443).

    Alternative splice isoforms for COQ7 Gene


neXtProt entry for COQ7 Gene

Proteomics data for COQ7 Gene at MOPED

Post-translational modifications for COQ7 Gene

  • Ubiquitination at Lys85
  • Modification sites at PhosphoSitePlus

Other Protein References for COQ7 Gene

No data available for DME Specific Peptides for COQ7 Gene

Domains for COQ7 Gene

Suggested Antigen Peptide Sequences for COQ7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q99807
  • Belongs to the COQ7 family.
genes like me logo Genes that share domains with COQ7: view

No data available for Gene Families for COQ7 Gene

Function for COQ7 Gene

Molecular function for COQ7 Gene

GENATLAS Biochemistry: coenzyme Q7 (rat,yeast) homolog C elegans longevity gene clk1 ortholog,expressed in heart and skeletal muscle,likely localized in the mitochondrial inner membrane
UniProtKB/Swiss-Prot Function: Involved in lifespan determination in ubiquinone-independent manner. Involved in ubiquinone biosynthesis. Potential central metabolic regulator (By similarity).

Gene Ontology (GO) - Molecular Function for COQ7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25339443
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with COQ7: view
genes like me logo Genes that share phenotypes with COQ7: view

Animal Models for COQ7 Gene

MGI Knock Outs for COQ7:

Animal Model Products

CRISPR Products

miRNA for COQ7 Gene

miRTarBase miRNAs that target COQ7

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for COQ7 Gene

Localization for COQ7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COQ7 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note=Synthesized as a preprotein that is imported into the mitochondrial matrix, where the sequence is cleaved off and the mature protein becomes loosely associated with the inner membrane. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for COQ7 Gene COMPARTMENTS Subcellular localization image for COQ7 gene
Compartment Confidence
mitochondrion 5
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for COQ7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane IEA --
genes like me logo Genes that share ontologies with COQ7: view

Pathways for COQ7 Gene

genes like me logo Genes that share pathways with COQ7: view

Pathways by source for COQ7 Gene

UniProtKB/Swiss-Prot Q99807-COQ7_HUMAN

  • Pathway: Cofactor biosynthesis; ubiquinone biosynthesis

Gene Ontology (GO) - Biological Process for COQ7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001306 age-dependent response to oxidative stress IEA --
GO:0001701 in utero embryonic development IEA --
GO:0001841 neural tube formation IEA --
GO:0006744 ubiquinone biosynthetic process TAS --
GO:0006979 response to oxidative stress --
genes like me logo Genes that share ontologies with COQ7: view

Compounds for COQ7 Gene

(3) HMDB Compounds for COQ7 Gene

Compound Synonyms Cas Number PubMed IDs
Not Available
2-Hexaprenyl-3-methyl-6-methoxy-1,4 benzoquinone
Not Available
  • Armco iron

(2) Novoseek inferred chemical compound relationships for COQ7 Gene

Compound -log(P) Hits PubMed IDs
coq7 98.6 15
ubiquinone 83.1 4
genes like me logo Genes that share compounds with COQ7: view

Transcripts for COQ7 Gene

Unigene Clusters for COQ7 Gene

Coenzyme Q7 homolog, ubiquinone (yeast):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COQ7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COQ7 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9
SP1: - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - -
SP8: - -
SP9: - - - - -

Relevant External Links for COQ7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COQ7 Gene

mRNA expression in normal human tissues for COQ7 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COQ7 Gene

SOURCE GeneReport for Unigene cluster for COQ7 Gene Hs.157113

mRNA Expression by UniProt/SwissProt for COQ7 Gene

Tissue specificity: Expressed dominantly in heart and skeletal muscle
genes like me logo Genes that share expressions with COQ7: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for COQ7 Gene

Orthologs for COQ7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for COQ7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COQ7 35
  • 98.77 (n)
  • 98.16 (a)
COQ7 36
  • 98 (a)
(Bos Taurus)
Mammalia COQ7 35
  • 88.94 (n)
  • 89.4 (a)
COQ7 36
  • 89 (a)
(Canis familiaris)
Mammalia COQ7 35
  • 87.71 (n)
  • 85.71 (a)
COQ7 36
  • 86 (a)
(Mus musculus)
Mammalia Coq7 35
  • 81.41 (n)
  • 85.25 (a)
Coq7 16
Coq7 36
  • 85 (a)
(Monodelphis domestica)
Mammalia COQ7 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia COQ7 36
  • 74 (a)
(Rattus norvegicus)
Mammalia Coq7 35
  • 81.41 (n)
  • 82.95 (a)
(Gallus gallus)
Aves COQ7 35
  • 68.39 (n)
  • 73.24 (a)
COQ7 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia coq7 35
  • 65.38 (n)
  • 69.71 (a)
Str.14928 35
(Danio rerio)
Actinopterygii coq7 35
  • 64.96 (n)
  • 72.16 (a)
coq7 36
  • 61 (a)
Dr.19634 35
fruit fly
(Drosophila melanogaster)
Insecta COQ7 35
  • 59.02 (n)
  • 58.24 (a)
COQ7 36
  • 51 (a)
COQ7 37
  • 57 (a)
(Caenorhabditis elegans)
Secernentea clk-1 35
  • 58.53 (n)
  • 56.4 (a)
clk-1 36
  • 53 (a)
clk-1 37
  • 56 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL162C 35
  • 52.22 (n)
  • 47.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAT5 35
  • 53.93 (n)
  • 48.31 (a)
CAT5 36
  • 39 (a)
CAT5 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E02421g 35
  • 53.41 (n)
  • 52.05 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03957 35
  • 52.73 (n)
  • 47.62 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes coq7 35
  • 54.35 (n)
  • 47.29 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7697 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2575 36
  • 59 (a)
Species with no ortholog for COQ7:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COQ7 Gene

Gene Tree for COQ7 (if available)
Gene Tree for COQ7 (if available)

Paralogs for COQ7 Gene

No data available for Paralogs for COQ7 Gene

Variants for COQ7 Gene

Sequence variations from dbSNP and Humsavar for COQ7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1135252 -- 19,077,340(+) TGAGC(A/C)CCATG reference, missense
rs4346187 -- 19,069,852(+) GATCT(C/T)AGCTC intron-variant
rs4494518 -- 19,072,912(+) acgcc(C/T)gtaat intron-variant
rs4782202 -- 19,071,899(+) TGATC(A/G)TAACG intron-variant
rs7185369 -- 19,076,881(+) gccac(C/T)gcgcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COQ7 Gene

Variant ID Type Subtype PubMed ID
esv587 CNV CNV 17122850
dgv823e1 CNV Complex 17122850
esv34419 CNV Gain 17911159
nsv436835 CNV Insertion 17901297
dgv2640n71 CNV Gain 21882294
nsv103187 CNV Loss 16902084

Relevant External Links for COQ7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COQ7 Gene

Disorders for COQ7 Gene

Relevant External Links for COQ7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with COQ7: view

No data available for UniProtKB/Swiss-Prot for COQ7 Gene

Publications for COQ7 Gene

  1. Orthologues of the Caenorhabditis elegans longevity gene clk-1 in mouse and human. (PMID: 10373327) Asaumi S. … Shirasawa T. (Genomics 1999) 3 4 23
  2. Conservation of the Caenorhabditis elegans timing gene clk-1 from yeast to human: a gene required for ubiquinone biosynthesis with potential implications for aging. (PMID: 10501970) Vajo Z. … Francomano C.A. (Mamm. Genome 1999) 3 4 23
  3. Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1. (PMID: 9020081) Ewbank J.J. … Hekimi S. (Science 1997) 2 3 4
  4. The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1. (PMID: 18927074) Wang Y. … Hekimi S. (J. Biol. Chem. 2009) 3 23
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4

Products for COQ7 Gene

Sources for COQ7 Gene

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