COQ5 Gene
protein-coding GIFtS: 54
GCID: GC12M120941
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|
coenzyme Q5 homolog, methyltransferase (S. cerevisiae)(Previous names: coenzyme Q5 homolog, methyltransferase (yeast) )
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Aliases for COQ5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Coenzyme Q5 Homolog, Methyltransferase (S. Cerevisiae)1 2 | | EC 2.1.1.2013 | | MGC47671 | | Ubiquinone Biosynthesis Methyltransferase COQ53 | | Coenzyme Q5 Homolog, Methyltransferase (Yeast)1 | | EC 2.1.18 | | 2-Methoxy-6-Polyprenyl-1,4-Benzoquinol Methylase, Mitochondrial2 | | EC 2.1.1.528 | | Ubiquinone Biosynthesis Methyltransferase COQ5, Mitochondrial2 | | |
Export aliases for COQ5 gene to outside databasesPrevious GC identifers: GC12M119404 GC12M117950 |
Summaries for COQ5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: COQ5_HUMAN, Q5HYK3Function: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
|
Genomic Views for COQ5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009775.17
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the COQ5 gene promoter: c-Fos AP-1 NF-YA NF-YB CBF-A CBF-B c-Jun CP1A NF-Y CBF(2) Other transcription factors
Search SABiosciences Chromatin IP Primers for COQ5
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COQ5 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.31 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.31COQ5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M120941: view genomic region
(about GC identifiers)
Start:
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120,941,077 bp from pter |
End:
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120,972,237 bp from pter |
Size:
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31,161 bases |
Orientation:
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minus strand |
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Proteins for COQ5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: COQ5_HUMAN, Q5HYK3 (See
protein sequence)Recommended Name: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial precursor Size: 327 amino acids; 37140 Da
Subcellular location: Mitochondrion (By similarity)
Secondary accessions: B4DEJ4 Q32Q28 Q53HH0 Q96LV1 Q9BSP8Alternative splicing: 2 isoforms: Q5HYK3-1 Q5HYK3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for COQ5: NX_Q5HYK3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5HYK3 4/10 DME Specific Peptides for COQ5 (Q5HYK3) (see all 10)
COQ5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115690.3 ENSEMBL proteins: ENSP00000288532 ENSP00000401798 ENSP00000449863 ENSP00000449874 ENSP00000450001 ENSP00000449933 Reactome Protein details: Q5HYK3 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
COQ5 for ontologies About GeneDecksing
COQ5 Antibody Products: Assay Products for COQ5: |
Protein
Domains / Families for COQ5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
COQ5 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5HYK3ProtoNet protein and cluster: Q5HYK3 1 Blocks protein family: IPB004033 UbiE/COQ5 methyltransferase
UniProtKB/Swiss-Prot: COQ5_HUMAN, Q5HYK3Similarity: Belongs to the methyltransferase superfamily. UbiE family |
Function for COQ5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: COQ5_HUMAN, Q5HYK3Function: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)Catalytic activity: S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol =S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinolEnzyme Numbers (IUBMB): EC 2.1.1.522 EC 2.1.12 EC 2.1.1.2011
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COQ5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COQ5 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: COQ5 (NM_032314) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COQ5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COQ5  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COQ5 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008168 | methyltransferase activity |
IEA | -- |
COQ5 for ontologies About GeneDecksing
|
Pathways & Interactions for COQ5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Metabolism | | | 2 | Ubiquinone and other terpenoid-quinone biosynthesis | |
Pathway sources See GeneCards unified pathways Show all pathways
3
Reactome Pathways for COQ5
2
Kegg Pathways (Kegg details for COQ5): UniProtKB/Swiss-Prot: COQ5_HUMAN, Q5HYK3Pathway: Cofactor biosynthesis; ubiquinone biosynthesis
COQ5 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COQ5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
 5/23 Interacting proteins for COQ5 (Q5HYK33 ENSP000002885324) via UniProtKB, MINT, STRING, and/or I2D (see all 23) About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006744 | ubiquinone biosynthetic process |
IEA | -- |
COQ5 for ontologies About GeneDecksing
|
Drugs & Compounds for COQ5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for COQ5
4 HMDB Compounds for COQ5 About this table Search CenterWatch for drugs/clinical trials and news about COQ5 
|
Transcripts for COQ5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for COQ5 gene: NM_032314.3 Unigene Cluster for COQ5: Coenzyme Q5 homolog, methyltransferase (S. cerevisiae) Hs.17250 [show with all ESTs]Unigene Representative Sequence: BX6475628 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000288532(uc001tyn.3 uc010szj.2) ENST00000445328 ENST00000552443 ENST00000546838 ENST00000547943 ENST00000551769 ENST00000547736 ENST00000547448
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COQ5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COQ5 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: COQ5 (NM_032314) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COQ5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COQ5  |
Additional cDNA sequence: AK057777.1 AK222610.1 AK225242.1 AK293656.1 AK298214.1 AK315681.1 BC004916.2 BC107874.1 BX647562.1 EU700459.1 11 DOTS entries: DT.116695 DT.100729220 DT.95080428 DT.97845829 DT.116696 DT.91749095 DT.91749088 DT.100832850 DT.121144763 DT.91749090 DT.100687173 24/253 AceView cDNA sequences (see all 253): CR608167 CR600322 CB250576 AW292840 BU686001 BX395594 W61153 AF062725 CR625099 AI110617 W31056 AV652171 CB138788 CR595710 AW438962 CR612918 CR619690 CA426745 BX399935 AK057777 AA720641 CA429879 CR602489 CB125089 GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for COQ5 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | |
| SP1: | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for COQ5
|
Expression for COQ5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| COQ5 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AGAATTGTGT
About this image See COQ5 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for COQ5
SOURCE GeneReport for Unigene cluster: Hs.17250 SABiosciences Custom PCR Arrays for COQ5
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COQ5 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COQ5 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COQ5 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COQ5 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COQ5 |
Orthologs for COQ5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for COQ5 gene from 11/39 species (see all 39) About this table
ENSEMBL Gene Tree for COQ5 (if available) TreeFam Gene Tree for COQ5 (if available)  |
Paralogs for COQ5 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for COQ5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 12 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for COQ5 (120941077 - 120972237 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for COQ5: -- Human Gene Mutation Database (HGMD): COQ5
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COQ5 |
|
Disorders
/ Diseases for COQ5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
COQ5 for disorders About GeneDecksing
4 diseases for COQ5: About MalaCardshomocysteine tuberculosis malaria mycobacterium tuberculosis Human Genome Epidemiology (HuGE) Navigator: COQ5 (1 document) Export disorders for COQ5 gene to outside databases
|
Publications for COQ5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for COQ5 gene integrated from 9 sources: (articles sorted by number of sources associating them with COQ5) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
|
External Searches for COQ5 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing COQ5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing COQ5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COQ5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for COQ5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for COQ5 gene: Search GeneIP for patents involving COQ5
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for COQ5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
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variant library, vector shuttling | | OriGene Custom Antibody Services for COQ5 | | OriGene Custom Protein Services for COQ5 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COQ5 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COQ5 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COQ5 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COQ5 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COQ5 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COQ5 |
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| | | Search Tocris compounds for COQ5 |
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 | | COQ5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COQ5 |
|  |  |  | | | ThermoFisher Antibodies for COQ5 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COQ5 |
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