Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COQ5 Gene

protein-coding   GIFtS: 56
GCID: GC12M120941

Coenzyme Q5 Homolog, Methyltransferase (S. Cerevisiae)

(Previous names: coenzyme Q5 homolog, methyltransferase (yeast))
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coenzyme Q5 Homolog, Methyltransferase (S. Cerevisiae)1 2     Ubiquinone Biosynthesis Methyltransferase COQ5, Mitochondrial2
2-methoxy-6-polyprenyl-11     EC 2.1.1.2013
4-Benzoquinol Methylase1     Ubiquinone Biosynthesis Methyltransferase COQ53
Coenzyme Q5 Homolog, Methyltransferase (Yeast)1     EC 2.1.18
2-Methoxy-6-Polyprenyl-1,4-Benzoquinol Methylase, Mitochondrial2     EC 2.1.1.528

External Ids:    HGNC: 287221   Entrez Gene: 842742   Ensembl: ENSG000001108717   UniProtKB: Q5HYK33   

Export aliases for COQ5 gene to outside databases

Previous GC identifers: GC12M119404 GC12M117950


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for COQ5 Gene: 
COQ5 (coenzyme Q5 homolog, methyltransferase (S. cerevisiae)) is a protein-coding gene. Diseases associated with COQ5 include tuberculosis, and among its related super-pathways are Metabolic pathways and Ubiquinol biosynthesis. GO annotations related to this gene include methyltransferase activity.

UniProtKB/Swiss-Prot: COQ5_HUMAN, Q5HYK3
Function: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to
2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009775.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COQ5 gene promoter:
         c-Fos   AP-1   NF-YA   NF-YB   CBF-A   CBF-B   c-Jun   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOQ5 promoter sequence
   Search SABiosciences Chromatin IP Primers for COQ5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COQ5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

COQ5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COQ5 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M120941:  view genomic region     (about GC identifiers)

Start:
120,941,077 bp from pter      End:
120,972,237 bp from pter
Size:
31,161 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: COQ5_HUMAN, Q5HYK3 (See protein sequence)
Recommended Name: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial precursor  
Size: 327 amino acids; 37140 Da
Subcellular location: Mitochondrion (By similarity)
Secondary accessions: B4DEJ4 Q32Q28 Q53HH0 Q96LV1 Q9BSP8
Alternative splicing: 2 isoforms:  Q5HYK3-1   Q5HYK3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for COQ5: NX_Q5HYK3

Explore proteomics data for COQ5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5HYK3

  • 4/10 DME Specific Peptides for COQ5 (Q5HYK3) (see all 10)
     MSLGIHR  AGGTGDI  YSFQVIP  LDVAGGT 

    COQ5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    COQ5 Protein Expression
    REFSEQ proteins: NP_115690.3  
    ENSEMBL proteins: 
     ENSP00000288532   ENSP00000401798   ENSP00000449863   ENSP00000449874   ENSP00000450001  
     ENSP00000449933  
    Reactome Protein details: Q5HYK3
    Human Recombinant Protein Products for COQ5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for COQ5
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for COQ5
    GenScript Custom Purified and Recombinant Proteins Services for COQ5
    Novus Biologicals COQ5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for COQ5 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    COQ5 for ontologies           About GeneDecksing



    COQ5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for COQ5
    GenScript Custom Superior Antibodies Services for COQ5
    Novus Biologicals COQ5 Antibody
    Abcam antibodies for COQ5
    Cloud-Clone Corp. Antibodies for COQ5 
    ThermoFisher Antibodies for COQ5
    LSBio Antibodies in human, mouse, rat for COQ5 

    Assay Products for COQ5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for COQ5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for COQ5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for COQ5 
    Cloud-Clone Corp. CLIAs for COQ5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR004033 UbiE/COQ5_MeTrFase
     IPR025765 UbiE/COQ5_MeTrFase_dom
     IPR023576 UbiE/COQ5_MeTrFase_CS

    Graphical View of Domain Structure for InterPro Entry Q5HYK3

    ProtoNet protein and cluster: Q5HYK3

    1 Blocks protein domain: IPB004033 UbiE/COQ5 methyltransferase

    UniProtKB/Swiss-Prot: COQ5_HUMAN, Q5HYK3
    Similarity: Belongs to the methyltransferase superfamily. UbiE family


    COQ5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COQ5_HUMAN, Q5HYK3
    Function: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to
    2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
    Catalytic activity: S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol =
    S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol

         Enzyme Numbers (IUBMB): EC 2.1.1.522 EC 2.1.12 EC 2.1.1.2011

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008168methyltransferase activity IEA--
         
    COQ5 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for COQ5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for COQ5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COQ5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COQ5 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COQ5
    1 QIAGEN miScript miRNA Assays for microRNA that regulate COQ5:
    hsa-miR-607
    SwitchGear 3'UTR luciferase reporter plasmidCOQ5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for COQ5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COQ5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for COQ5
    Sirion Biotech Customized adenovirus for overexpression of COQ5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for COQ5 (see all 8)
    OriGene ORF clones in mouse, rat for COQ5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COQ5 (NM_032314)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COQ5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COQ5
    Sirion Biotech Customized lentivirus for stable overexpression of COQ5 
                         Customized lentivirus expression plasmids for stable overexpression of COQ5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for COQ5
    Search LifeMap BioReagents cell lines for COQ5
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COQ5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for COQ5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    2Ubiquinone and other terpenoid-quinone biosynthesis
    Ubiquinol biosynthesis0.42
    Ubiquinone and other terpenoid-quinone biosynthesis0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for COQ5
        Metabolism
    Ubiquinol biosynthesis
    Metabolism of lipids and lipoproteins


    2         Kegg Pathways  (Kegg details for COQ5):
        Ubiquinone and other terpenoid-quinone biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: COQ5_HUMAN, Q5HYK3
    Pathway: Cofactor biosynthesis; ubiquinone biosynthesis


    COQ5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COQ5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/23 Interacting proteins for COQ5 (Q5HYK33 ENSP000002885324) via UniProtKB, MINT, STRING, and/or I2D (see all 23)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASKO149363, ENSP000003674084I2D: score=5 STRING: ENSP00000367408
    MOCS3O953963, ENSP000002440514I2D: score=2 STRING: ENSP00000244051
    ADCK3Q8NI603, ENSP000003557394I2D: score=1 STRING: ENSP00000355739
    RHOT1Q8IXI23, ENSP000003511324I2D: score=1 STRING: ENSP00000351132
    CSNK1G2P783683I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006744ubiquinone biosynthetic process TAS--
    GO:0008152metabolic process ----
    GO:0044281small molecule metabolic process TAS--

    COQ5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for COQ5

    4 HMDB Compounds for COQ5    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Hexaprenyl-3-methyl-6-methoxy-1,4 benzoquinone ----
    2-Hexaprenyl-6-methoxy-1,4-benzoquinone2-polyprenyl-6-methoxy-1,4-benzoquinol (see all 2)----
    DifucosyllactohexaoseDFH (see all 3)115236-57-2--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    Search CenterWatch for drugs/clinical trials and news about COQ5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for COQ5 gene: 
    NM_032314.3  

    Unigene Cluster for COQ5:

    Coenzyme Q5 homolog, methyltransferase (S. cerevisiae)
    Hs.17250  [show with all ESTs]
    Unigene Representative Sequence: BX647562
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000288532(uc001tyn.3 uc010szj.2) ENST00000445328 ENST00000552443
    ENST00000546838 ENST00000547943 ENST00000551769 ENST00000547736 ENST00000547448

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COQ5
    1 QIAGEN miScript miRNA Assays for microRNA that regulate COQ5:
    hsa-miR-607
    SwitchGear 3'UTR luciferase reporter plasmidCOQ5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for COQ5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COQ5
    Clone
    Products:
         
    OriGene clones in human, mouse for COQ5 (see all 8)
    OriGene ORF clones in mouse, rat for COQ5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COQ5 (NM_032314)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COQ5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COQ5
    Sirion Biotech Customized lentivirus for stable overexpression of COQ5 
                         Customized lentivirus expression plasmids for stable overexpression of COQ5 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for COQ5
    OriGene qSTAR qPCR primer pairs in human, mouse for COQ5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COQ5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COQ5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COQ5

    Additional mRNA sequence: 

    AK057777.1 AK222610.1 AK225242.1 AK293656.1 AK298214.1 AK315681.1 BC004916.2 BC107874.1 
    BX647562.1 EU700459.1 

    11 DOTS entries:

    DT.116695  DT.100729220  DT.95080428  DT.97845829  DT.116696  DT.91749095  DT.91749088  DT.100832850 
    DT.121144763  DT.91749090  DT.100687173 

    24/253 AceView cDNA sequences (see all 253):

    AA720641 W31056 CR591293 CR596271 CR625099 CB125089 CA441965 BU733709 
    AI110617 AF062725 CR608167 CR601281 BM971358 BQ771956 CR607035 AA811239 
    BQ018651 AV652171 CR602489 BX399935 CB138788 BM705792 BU686001 AW438962 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for COQ5 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:              -     -     -                                                   
    SP2:              -           -                                                   
    SP3:              -     -     -                                                   
    SP4:              -     -     -     -                                             
    SP5:              -                                                               


    ECgene alternative splicing isoforms for COQ5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COQ5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAATTGTGT
    COQ5 Expression
    About this image


    See COQ5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COQ5

    SOURCE GeneReport for Unigene cluster: Hs.17250
        SABiosciences Custom PCR Arrays for COQ5
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for COQ5
    OriGene qSTAR qPCR primer pairs in human, mouse for COQ5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COQ5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COQ5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COQ5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COQ5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COQ5 gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Coq51 , 5 coenzyme Q5 homolog, methyltransferase (yeast)1, 5 83.69(n)1
    83.79(a)1
      5 (56.03 cM)5
    520641  NM_026504.21  NP_080780.11 
     1152796665 
    chicken
    (Gallus gallus)
    Aves COQ51 coenzyme Q5 homolog, methyltransferase (S. cerevisiae) 71.33(n)
    76.11(a)
      416975  NM_001006194.1  NP_001006194.1 
    lizard
    (Anolis carolinensis)
    Reptilia COQ56
    coenzyme Q5 homolog, methyltransferase (S. cerevis...
    73(a)
    1 ↔ 1
    GL343338.1(92731-96210)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.259972 Xenopus laevis transcribed sequence with weak similarity more 74.31(n)    BJ626741.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:924451 zgc:92445 66.32(n)
    70.1(a)
      447802  NM_001004541.1  NP_001004541.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG24531 CG2453 61.6(n)
    61.2(a)
      32272  NM_132637.1  NP_572865.1 
    worm
    (Caenorhabditis elegans)
    Secernentea coq-51 Protein COQ-5 56.29(n)
    52.7(a)
      176099  NM_066303.5  NP_498704.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes COQ5(YML110C)4
    COQ51
    2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, more4
    Coq5p1
    57.35(n)1
    52.63(a)1
      13(50954-50031)4
    8549301, 4  NP_013597.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G573001 ubiquinone biosynthesis methyltransferase COQ5 60.29(n)
    59.93(a)
      835835  NM_001085291.2  NP_001078760.1 
    rice
    (Oryza sativa)
    Liliopsida NM_189505.12   -- 74.1(n)    NM_189505.1 


    ENSEMBL Gene Tree for COQ5 (if available)
    TreeFam Gene Tree for COQ5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for COQ5 gene
    18/151 SIMAP similar genes for COQ5 using alignment to 6 protein entries:     COQ5_HUMAN (see all proteins) (see all similar genes):
    SIPA1L3    TNNT1    NXPE2    HDGFRP2    IRF5    ARL6IP5
    DCAF17    PPIL6    TM4SF19    UBXN4    EIF3G    NDC80
    SNRPF    TBCB    C12orf76    ETFA    KIAA1651    MAP4K1

    COQ5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/614 SNPs in COQ5 are shown (see all 614)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1830959721,2
    --120940612(+) ATCATA/GCCCAG 1 -- int10--------
    rs1881382561,2
    C--120940657(+) CACCAC/TGCTGG 1 -- int10--------
    rs1914754811,2
    --120940786(+) CTGAAA/CGAATG 1 -- int10--------
    rs1821095421,2
    C--120940818(+) CAGGCA/GCGGCC 1 -- int10--------
    rs17101361,2
    C,F--120940864(+) AAAAAT/ATAGCC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1880848911,2
    --120940865(+) AAAATG/TAGCCG 1 -- int10--------
    rs110651441,2
    C,F,A--120940881(+) GGTGGC/TGCGCA 1 -- int14Minor allele frequency- T:0.50NA 8
    rs1451735091,2
    --120940883(+) TGGCGC/TGCACC 1 -- int10--------
    rs1423141221,2
    C--120940926(+) GAGAAC/TTGCTT 1 -- int10--------
    rs1924854921,2
    --120940967(+) GAGATG/TGCACC 1 -- int10--------

    HapMap Linkage Disequilibrium report for COQ5 (120941077 - 120972237 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for COQ5: --

    Human Gene Mutation Database (HGMD): COQ5
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing COQ5
    DNA2.0 Custom Variant and Variant Library Synthesis for COQ5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for COQ5:    About MalaCards
    tuberculosis    


    COQ5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): COQ5
    Human Genome Epidemiology (HuGE) Navigator: COQ5 (1 document)

    Export disorders for COQ5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COQ5 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with COQ5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Detection of suppressed maturation of the human COQ5 p rotein in the mitochondria following mitochondrial uncoupling by an antibody rec ognizing both precursor and mature forms of COQ5. (PubMed id 23354120)1 Chen S.W....Yen H.C. (2013)
    5. New susceptibility loci associated with kidney disease in type 1 diabetes. (PubMed id 23028342)1 Sandholm N....Maxwell A.P. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    9. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84274 HGNC: 28722 AceView: MGC4767 Ensembl:ENSG00000110871 euGenes: HUgn84274
    ECgene: COQ5 Kegg: 84274 H-InvDB: COQ5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COQ5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for COQ5 gene:
    Search GeneIP for patents involving COQ5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for COQ5  
     OriGene qPCR primer pairs and template standards for COQ5   OriGene Protein Over-expression Lysate for COQ5  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for COQ5  
     OriGene qSTAR qPCR primer pairs in human, mouse for COQ5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for COQ5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for COQ5   OriGene Custom Protein Services for COQ5  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COQ5
     QIAGEN SeqTarget long-range PCR primers for resequencing COQ5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COQ5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COQ5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COQ5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COQ5
     GenScript Custom Purified and Recombinant Proteins Services for COQ5 GenScript cDNA clones with any tag delivered in your preferred vector for COQ5
     GenScript Custom Assay Services for COQ5 GenScript Custom Superior Antibodies Services for COQ5
     GenScript Custom overexpressing Cell Line Services for COQ5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in COQ5 promoter
     Search Chromatin IP Primers for COQ5
     RT2 qPCR Primer Assay in human, mouse, rat COQ5
     Search GNC Networks for COQ5
     SABiosciences Custom PCR Arrays for COQ5
     Search Tocris compounds for COQ5
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     COQ5 antibodies
     COQ5 lysates
     Antibodies for COQ5
     See all of Abcam's Antibodies, Kits and Proteins for COQ5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for COQ5
     Antibodies for COQ5
     ELISAs for COQ5
     CLIAs for COQ5
     Search LifeMap BioReagents cell lines for COQ5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COQ5
     SwitchGear 3'UTR luciferase reporter plasmids for COQ5
     SwitchGear Promoter luciferase reporter plasmids for COQ5
     ThermoFisher Antibodies for COQ5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COQ5
     inGenious Targeting Laboratory - Custom generated mouse model solutions for COQ5
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for COQ5
    Customized:
     lentivirus for stable overexpression of COQ5
     lentivirus expression plasmids for stable overexpression of COQ5
     adenovirus for overexpression of COQ5
     LSBio Antibodies in human, mouse, rat for COQ5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      COQ5 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4