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Aliases for COQ5 Gene

Aliases for COQ5 Gene

  • Coenzyme Q5 Homolog, Methyltransferase (S. Cerevisiae) 2 3
  • 2-Methoxy-6-Polyprenyl-1,4-Benzoquinol Methylase 2
  • Coenzyme Q5 Homolog, Methyltransferase (Yeast) 2
  • Ubiquinone Biosynthesis Methyltransferase COQ5 4
  • EC 2.1.1.201 4
  • EC 2.1.1.52 63
  • EC 2.1.1 63

External Ids for COQ5 Gene

Previous GeneCards Identifiers for COQ5 Gene

  • GC12M119404
  • GC12M120941
  • GC12M117950

Summaries for COQ5 Gene

GeneCards Summary for COQ5 Gene

COQ5 (Coenzyme Q5 Homolog, Methyltransferase (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include methyltransferase activity.

UniProtKB/Swiss-Prot for COQ5 Gene

  • Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COQ5 Gene

Genomics for COQ5 Gene

Regulatory Elements for COQ5 Gene

Genomic Location for COQ5 Gene

Start:
120,503,274 bp from pter
End:
120,534,434 bp from pter
Size:
31,161 bases
Orientation:
Minus strand

Genomic View for COQ5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COQ5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COQ5 Gene

Proteins for COQ5 Gene

  • Protein details for COQ5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5HYK3-COQ5_HUMAN
    Recommended name:
    2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
    Protein Accession:
    Q5HYK3
    Secondary Accessions:
    • B4DEJ4
    • Q32Q28
    • Q53HH0
    • Q96LV1
    • Q9BSP8

    Protein attributes for COQ5 Gene

    Size:
    327 amino acids
    Molecular mass:
    37140 Da
    Quaternary structure:
    • Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.

    Alternative splice isoforms for COQ5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COQ5 Gene

Proteomics data for COQ5 Gene at MOPED

Selected DME Specific Peptides for COQ5 Gene

Post-translational modifications for COQ5 Gene

  • Ubiquitination at Lys95
  • Modification sites at PhosphoSitePlus

Other Protein References for COQ5 Gene

Domains for COQ5 Gene

Protein Domains for COQ5 Gene

Graphical View of Domain Structure for InterPro Entry

Q5HYK3

UniProtKB/Swiss-Prot:

COQ5_HUMAN :
  • Q5HYK3
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
genes like me logo Genes that share domains with COQ5: view

No data available for Gene Families for COQ5 Gene

Function for COQ5 Gene

Molecular function for COQ5 Gene

UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.
UniProtKB/Swiss-Prot Function: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

Enzyme Numbers (IUBMB) for COQ5 Gene

Gene Ontology (GO) - Molecular Function for COQ5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity --
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity IBA --
genes like me logo Genes that share ontologies with COQ5: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COQ5

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for COQ5 Gene

Localization for COQ5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COQ5 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COQ5 Gene COMPARTMENTS Subcellular localization image for COQ5 gene
Compartment Confidence
mitochondrion 3
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for COQ5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA --
genes like me logo Genes that share ontologies with COQ5: view

Pathways for COQ5 Gene

genes like me logo Genes that share pathways with COQ5: view

Pathways by source for COQ5 Gene

UniProtKB/Swiss-Prot Q5HYK3-COQ5_HUMAN

  • Pathway: Cofactor biosynthesis; ubiquinone biosynthesis.

Gene Ontology (GO) - Biological Process for COQ5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006744 ubiquinone biosynthetic process TAS --
GO:0008152 metabolic process --
GO:0032259 methylation IBA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with COQ5: view

Compounds for COQ5 Gene

(4) HMDB Compounds for COQ5 Gene

Compound Synonyms Cas Number PubMed IDs
2-Hexaprenyl-3-methyl-6-methoxy-1,4 benzoquinone
Not Available
2-Hexaprenyl-6-methoxy-1,4-benzoquinone
  • 2-polyprenyl-6-methoxy-1,4-benzoquinol
Not Available
Difucosyllactohexaose
  • DFH
115236-57-2
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0
genes like me logo Genes that share compounds with COQ5: view

Transcripts for COQ5 Gene

Unigene Clusters for COQ5 Gene

Coenzyme Q5 homolog, methyltransferase (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COQ5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COQ5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5: -
SP6: -

Relevant External Links for COQ5 Gene

GeneLoc Exon Structure for
COQ5
ECgene alternative splicing isoforms for
COQ5

Expression for COQ5 Gene

mRNA expression in normal human tissues for COQ5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COQ5 Gene

SOURCE GeneReport for Unigene cluster for COQ5 Gene Hs.17250

genes like me logo Genes that share expressions with COQ5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COQ5 Gene

Orthologs for COQ5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COQ5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COQ5 35
  • 99.49 (n)
  • 98.78 (a)
COQ5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COQ5 35
  • 90.42 (n)
  • 89.6 (a)
COQ5 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COQ5 35
  • 89.09 (n)
  • 89.3 (a)
COQ5 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Coq5 35
  • 83.69 (n)
  • 83.79 (a)
Coq5 16
Coq5 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COQ5 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COQ5 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Coq5 35
  • 84.51 (n)
  • 85.63 (a)
chicken
(Gallus gallus)
Aves COQ5 35
  • 71.33 (n)
  • 76.11 (a)
COQ5 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COQ5 36
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25997 35
tropical clawed frog
(Silurana tropicalis)
Amphibia coq5 35
  • 67.86 (n)
  • 73.29 (a)
zebrafish
(Danio rerio)
Actinopterygii COQ5 36
  • 64 (a)
OneToOne
zgc:92445 35
  • 63.98 (n)
  • 66.25 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010488 35
  • 58.66 (n)
  • 58.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2453 35
  • 61.33 (n)
  • 61.2 (a)
CG2453 36
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea coq-5 35
  • 56.78 (n)
  • 54.07 (a)
coq-5 36
  • 45 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL132W 35
  • 53.33 (n)
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COQ5 35
  • 55.35 (n)
  • 49.82 (a)
COQ5 36
  • 44 (a)
OneToOne
COQ5 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D01771g 35
  • 57.12 (n)
  • 52.02 (a)
soybean
(Glycine max)
eudicotyledons Gma.12739 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G57300 35
  • 60.29 (n)
  • 59.93 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.10592 35
rice
(Oryza sativa)
Liliopsida Os01g0976600 35
  • 59.79 (n)
  • 57.73 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.3669 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09862 35
  • 55.73 (n)
  • 55.2 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes coq5 35
  • 55.65 (n)
  • 54.03 (a)
Species with no ortholog for COQ5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for COQ5 Gene

ENSEMBL:
Gene Tree for COQ5 (if available)
TreeFam:
Gene Tree for COQ5 (if available)

Paralogs for COQ5 Gene

genes like me logo Genes that share paralogs with COQ5: view

No data available for Paralogs for COQ5 Gene

Variants for COQ5 Gene

Sequence variations from dbSNP and Humsavar for COQ5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs7471 -- 120,503,412(-) ACCCA(A/G)TGACA utr-variant-3-prime
rs14017 -- 120,503,641(+) CACTT(C/T)GAGAC utr-variant-3-prime
rs15453 -- 120,503,397(+) TTTCT(A/G)GTTAA utr-variant-3-prime
rs496370 -- 120,509,777(-) AGAGA(G/T)AGATA intron-variant
rs500003 -- 120,510,145(-) AGACC(C/T)GGAAC intron-variant

Relevant External Links for COQ5 Gene

HapMap Linkage Disequilibrium report
COQ5
Human Gene Mutation Database (HGMD)
COQ5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for COQ5 Gene

Disorders for COQ5 Gene

Relevant External Links for COQ5

Genetic Association Database (GAD)
COQ5
Human Genome Epidemiology (HuGE) Navigator
COQ5
genes like me logo Genes that share disorders with COQ5: view

No data available for UniProtKB/Swiss-Prot for COQ5 Gene

Publications for COQ5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. Molecular characterization of the human COQ5 C-methyltransferase in coenzyme Q10 biosynthesis. (PMID: 25152161) Nguyen T.P. … Salviati L. (Biochim. Biophys. Acta 2014) 2 3
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4

Products for COQ5 Gene

Sources for COQ5 Gene

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