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COQ4 Gene

protein-coding   GIFtS: 53
GCID: GC09P131084

Coenzyme Q4

(Previous names: coenzyme Q4 homolog (yeast), coenzyme Q4 homolog (S. cerevisiae))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coenzyme Q41 2     CGI-922
Coenzyme Q Biosynthesis Protein 4 Homolog2 3     Coenzyme Q4 Homolog2
Coenzyme Q4 Homolog (S. Cerevisiae)1     Ubiquinone Biosynthesis Protein COQ4 Homolog, Mitochondrial2
Coenzyme Q4 Homolog (Yeast)1     

External Ids:    HGNC: 196931   Entrez Gene: 511172   Ensembl: ENSG000001671137   OMIM: 6128985   UniProtKB: Q9Y3A03   

Export aliases for COQ4 gene to outside databases

Previous GC identifers: GC09P122199 GC09P122731 GC09P124538 GC09P126460 GC09P128164 GC09P130124 GC09P100697


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COQ4 Gene:
Coenzyme Q (CoQ) is a small lipophilic molecule that transports electrons between mitochondrial respiratory chain
complexes and functions as a cofactor for mitochondrial enzymes. COQ4 is an enzyme involved in CoQ biosynthesis
(Casarin et al., 2008 (PubMed 18474229)).(supplied by OMIM, Aug 2009)

GeneCards Summary for COQ4 Gene:
COQ4 (coenzyme Q4) is a protein-coding gene.

UniProtKB/Swiss-Prot: COQ4_HUMAN, Q9Y3A0
Function: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ
enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides

Gene Wiki entry for COQ4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the COQ4 gene promoter:
         NF-1   NF-1/L   AML1a   GCNF   Olf-1   POU2F1   GCNF-1   POU2F1a   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOQ4 promoter sequence
   Search Chromatin IP Primers for COQ4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COQ4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.2

COQ4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COQ4 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P131084:  view genomic region     (about GC identifiers)

Start:
131,084,791 bp from pter      End:
131,096,351 bp from pter
Size:
11,561 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: COQ4_HUMAN, Q9Y3A0 (See protein sequence)
Recommended Name: Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial precursor  
Size: 265 amino acids; 29657 Da
Subunit: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and
COQ9 (By similarity)
Secondary accessions: A8WBK8 B2R958 Q5T4B8 Q96EW4
Alternative splicing: 2 isoforms:  Q9Y3A0-1   Q9Y3A0-2   

Explore the universe of human proteins at neXtProt for COQ4: NX_Q9Y3A0

Explore proteomics data for COQ4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See COQ4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057119.2  
    ENSEMBL proteins: 
     ENSP00000300452   ENSP00000477292   ENSP00000476323   ENSP00000361966  

    COQ4 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for COQ4
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    Novus Biologicals COQ4 Protein
    Novus Biologicals COQ4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for COQ4

     
    Search eBioscience for Proteins for COQ4 

     
    antibodies-online proteins for COQ4 (4 products) 

     
    Search antibodies-online for peptides for COQ4

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    Cloud-Clone Corp. ELISAs for COQ4
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    antibodies-online kits for COQ4 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR007715 Coq4
     IPR027540 Coq4_euk

    Graphical View of Domain Structure for InterPro Entry Q9Y3A0

    ProtoNet protein and cluster: Q9Y3A0

    1 Blocks protein domain: IPB007715 Coenzyme Q biosynthesis Coq4

    UniProtKB/Swiss-Prot: COQ4_HUMAN, Q9Y3A0
    Similarity: Belongs to the COQ4 family


    Find genes that share domains with COQ4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COQ4_HUMAN, Q9Y3A0
    Function: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ
    enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides

    Phenotypes:
         1 GenomeRNAi human phenotype for COQ4:

     Increased S DNA content 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Coq4):
     homeostasis/metabolism  mortality/aging 

    Find genes that share phenotypes with COQ4           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for COQ4

    miRNA
    Products:
        
    miRTarBase miRNAs that target COQ4:
    hsa-mir-1908-5p (MIRT035808)

    Block miRNA regulation of human, mouse, rat COQ4 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate COQ4:
    hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmidCOQ4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for COQ4
    Predesigned siRNA for gene silencing in human, mouse, rat COQ4

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: COQ4 (NM_016035)
    Sino Biological Human cDNA Clone for COQ4
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COQ4

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COQ4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COQ4_HUMAN, Q9Y3A0: Isoform 1: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane IEA--

    Find genes that share ontologies with COQ4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: COQ4_HUMAN, Q9Y3A0
    Pathway: Cofactor biosynthesis; ubiquinone biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for COQ4
    Interactions:

        Search GeneGlobe Interaction Network for COQ4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for COQ4 (Q9Y3A03 ENSP000003004524) via UniProtKB, MINT, STRING, and/or I2D (see all 53)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006744ubiquinone biosynthetic process IEA--

    Find genes that share ontologies with COQ4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COQ4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for COQ4 gene: 
    NM_016035.3  

    Unigene Cluster for COQ4:

    Coenzyme Q4 homolog (S. cerevisiae)
    Hs.98541  [show with all ESTs]
    Unigene Representative Sequence: AK128853
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300452(uc004bur.4 uc010mxy.3) ENST00000609948 ENST00000608951
    ENST00000372875(uc011max.1) ENST00000461102
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat COQ4 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate COQ4:
    hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmidCOQ4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for COQ4
    Predesigned siRNA for gene silencing in human, mouse, rat COQ4
    Clone
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    OriGene clones in human, mouse for COQ4 (see all 7)
    OriGene ORF clones in mouse, rat for COQ4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COQ4 (NM_016035)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COQ4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COQ4
    Primer
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    OriGene qPCR primer pairs and template standards for COQ4
    OriGene qSTAR qPCR primer pairs in human, mouse for COQ4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COQ4
      QuantiTect SYBR Green Assays in human, mouse, rat COQ4
      QuantiFast Probe-based Assays in human, mouse, rat COQ4

    Additional mRNA sequence: 

    AF151850.1 AK025376.1 AK095083.1 AK126646.1 AK128853.1 AK301333.1 AK313650.1 BC011895.2 
    BC036603.1 EU216419.1 EU216420.1 EU216421.1 EU216422.1 EU216423.1 

    15 DOTS entries:

    DT.447450  DT.100823076  DT.91766403  DT.100823077  DT.99952460  DT.87046211  DT.99958266  DT.95150420 
    DT.97768658  DT.121166364  DT.91766402  DT.97855891  DT.100789460  DT.314672  DT.95263226 

    Selected AceView cDNA sequences (see all 258):

    AA421811 CR594347 BP871280 CR601285 BM784038 CR607746 BG680957 AI658532 
    BM756360 AA330945 BM784017 BC011895 AU103015 AW300806 BF436365 CR602433 
    AI424398 BQ575020 CA306121 BQ184310 CD678629 BF431886 BM766876 AI334189 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for COQ4 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d
    SP1:                                                  -     -                 -     -           -     -     -     -           -                                 
    SP2:                          -     -     -           -     -                 -     -           -     -     -     -                                             
    SP3:                                                  -     -     -     -     -     -           -     -     -     -     -     -     -                           
    SP4:                                                  -     -                 -     -                                                                           
    SP5:                                                                                                                          -                                 


    ECgene alternative splicing isoforms for COQ4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COQ4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGGATGTC
    COQ4 Expression
    About this image


    COQ4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    COQ4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COQ4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.98541

    UniProtKB/Swiss-Prot: COQ4_HUMAN, Q9Y3A0
    Tissue specificity: Expressed ubiquitously, but at high levels in liver, lung and pancreas

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    QuantiFast Probe-based Assays in human, mouse, rat COQ4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COQ4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COQ4 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Coq41 , 5 coenzyme Q4 homolog (yeast)1, 5 83.33(n)1
    84.96(a)1
      2 (20.62 cM)5
    2276831  NM_178693.41  NP_848808.11 
     297874935 
    chicken
    (Gallus gallus)
    Aves COQ41 coenzyme Q4 homolog (S. cerevisiae) 72.86(n)
    73.45(a)
      417219  XM_415503.3  XP_415503.2 
    lizard
    (Anolis carolinensis)
    Reptilia COQ46
    coenzyme Q4
    50(a)
    1 ↔ 1
    GL343763.1(329-5375)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.159212 Xenopus laevis transcribed sequence with moderate similarity more 74.33(n)    BJ040057.1 
    zebrafish
    (Danio rerio)
    Actinopterygii coq41 coenzyme Q4 homolog (S. cerevisiae) 61.23(n)
    68.72(a)
      100137123  NM_001114720.1  NP_001108192.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG321741 CG32174 55.13(n)
    49.76(a)
      261607  NM_168732.3  NP_730270.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T03F1.23
    coq-41
    coq-41 43(a)3
    48.2(n)1
    43.69(a)1
      I(3869223-3870888)3
    1719661  NM_058845.41  NP_491246.41 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes COQ4(YDR204W)4
    COQ41
    Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, more4
    COQ41
    47.23(n)1
    39.46(a)1
      4(858137-859144)4
    8517851, 4  NP_010490.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G036901 AT2G03690 46.54(n)
    41.01(a)
      814897  NM_126417.2  NP_178465.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g06742001 Os04g0674200 48.96(n)
    38.28(a)
      4337378  NM_001060772.1  NP_001054237.1 


    ENSEMBL Gene Tree for COQ4 (if available)
    TreeFam Gene Tree for COQ4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COQ4 (see all 370)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1411090871,2
    --131095365(+) TTTTAG/TTAGAG 1 -- us2k10--------
    rs1886586021,2
    C--131095404(+) GTCTCA/GAACTC 1 -- us2k10--------
    rs1498389551,2
    C--131095661(+) TTTTGA/GGACGG 1 -- us2k10--------
    rs1410299051,2
    C--131095712(+) TTCGG-/CTC   
       ACTGC
    AACCT
    1 -- us2k10--------
    rs1468497251,2
    --131095726(+) ACCTCC/TGCCTC 1 -- us2k10--------
    rs1811444771,2
    --131095786(+) CAGGCA/GCCTGC 1 -- us2k10--------
    rs1853376851,2
    --131095791(+) GCCTGC/TCACCA 1 -- us2k10--------
    rs1457907871,2
    --131095801(+) ACTCCC/TGGCTA 1 -- us2k10--------
    rs1386186341,2
    --131095891(+) TCCTCA/GGCCTC 1 -- us2k10--------
    rs1120296741,2
    C,F--131095914(+) GATTAC/TAGGCG 1 -- us2k11Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for COQ4 (131084791 - 131096351 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for COQ4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831728CNV Loss17160897
    dgv8294n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): COQ4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COQ4
    DNA2.0 Custom Variant and Variant Library Synthesis for COQ4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612898    OMIM disorders: --


    Find genes that share disorders with COQ4           About GenesLikeMe

    Genetic Association Database (GAD): COQ4
    Human Genome Epidemiology (HuGE) Navigator: COQ4 (1 document)

    Export disorders for COQ4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COQ4 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with COQ4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional characterization of human COQ4, a gene required for coenzyme Q10 biosynthesis. (PubMed id 18474229)1, 2, 3 Casarin A.... Salviati L. (Biochem. Biophys. Res. Commun. 2008)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Yeast COQ4 encodes a mitochondrial protein required for coenzyme Q synthesis. (PubMed id 11469793)1, 3 Belogrudov G.I....Clarke C.F. (Arch. Biochem. Biophys. 2001)
    5. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    6. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    7. Haploinsufficiency of COQ4 causes coenzyme Q10 deficiency. (PubMed id 22368301)1 Salviati L....Navas P. (J. Med. Genet. 2012)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51117 HGNC: 19693 AceView: COQ4 Ensembl:ENSG00000167113 euGenes: HUgn51117
    ECgene: COQ4 H-InvDB: COQ4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for COQ4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for COQ4 gene:
    Search GeneIP for patents involving COQ4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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