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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COQ4 Gene

protein-coding   GIFtS: 52
GCID: GC09P131084

Coenzyme Q4 Homolog (S. Cerevisiae)

(Previous name: coenzyme Q4 homolog (yeast))
  Search for COQ4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coenzyme Q4 Homolog (S. Cerevisiae)1 2
Coenzyme Q Biosynthesis Protein 4 Homolog2 3
Coenzyme Q4 Homolog (Yeast)1
CGI-922
Ubiquinone Biosynthesis Protein COQ4 Homolog, Mitochondrial2

External Ids:    HGNC: 196931   Entrez Gene: 511172   Ensembl: ENSG000001671137   OMIM: 6128985   UniProtKB: Q9Y3A03   

Export aliases for COQ4 gene to outside databases

Previous GC identifers: GC09P122199 GC09P122731 GC09P124538 GC09P126460 GC09P128164 GC09P130124 GC09P100697


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COQ4 Gene:
Coenzyme Q (CoQ) is a small lipophilic molecule that transports electrons between mitochondrial respiratory chain
complexes and functions as a cofactor for mitochondrial enzymes. COQ4 is an enzyme involved in CoQ biosynthesis
(Casarin et al., 2008 (PubMed 18474229)).(supplied by OMIM, Aug 2009)

GeneCards Summary for COQ4 Gene: 
COQ4 (coenzyme Q4 homolog (S. cerevisiae)) is a protein-coding gene.

UniProtKB/Swiss-Prot: COQ4_HUMAN, Q9Y3A0
Function: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ
enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides

Gene Wiki entry for COQ4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COQ4 gene promoter:
         NF-1   NF-1/L   AML1a   GCNF   Olf-1   POU2F1   GCNF-1   POU2F1a   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOQ4 promoter sequence
   Search SABiosciences Chromatin IP Primers for COQ4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COQ4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.2

COQ4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COQ4 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P131084:  view genomic region     (about GC identifiers)

Start:
131,084,791 bp from pter      End:
131,096,351 bp from pter
Size:
11,561 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: COQ4_HUMAN, Q9Y3A0 (See protein sequence)
Recommended Name: Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial precursor  
Size: 265 amino acids; 29657 Da
Subunit: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and
COQ9 (By similarity)
Subcellular location: Isoform 1: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side
Secondary accessions: A8WBK8 B2R958 Q5T4B8 Q96EW4
Alternative splicing: 2 isoforms:  Q9Y3A0-1   Q9Y3A0-2   

Explore the universe of human proteins at neXtProt for COQ4: NX_Q9Y3A0

Explore proteomics data for COQ4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y3A0

  • COQ4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    COQ4 Protein Expression
    REFSEQ proteins: NP_057119.2  
    ENSEMBL proteins: 
     ENSP00000300452   ENSP00000361966  

    Human Recombinant Protein Products for COQ4: 
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    OriGene Protein Over-expression Lysate for COQ4
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    OriGene Custom Protein Services for COQ4
    GenScript Custom Purified and Recombinant Proteins Services for COQ4
    Novus Biologicals COQ4 Protein
    Novus Biologicals COQ4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for COQ4 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane IEA--

    COQ4 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for COQ4 
    Cloud-Clone Corp. CLIAs for COQ4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR007715 Coq4
     IPR027540 Coq4_euk

    Graphical View of Domain Structure for InterPro Entry Q9Y3A0

    ProtoNet protein and cluster: Q9Y3A0

    1 Blocks protein domain: IPB007715 Coenzyme Q biosynthesis Coq4

    UniProtKB/Swiss-Prot: COQ4_HUMAN, Q9Y3A0
    Similarity: Belongs to the COQ4 family


    COQ4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COQ4_HUMAN, Q9Y3A0
    Function: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ
    enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides

    Phenotypes:
         1 GenomeRNAi human phenotype for COQ4:

     Increased S DNA content 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Coq4):
     homeostasis/metabolism  mortality/aging 

    COQ4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for COQ4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for COQ4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COQ4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COQ4 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COQ4
    1 QIAGEN miScript miRNA Assays for microRNA that regulate COQ4:
    hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmidCOQ4 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    GenScript: all cDNA clones in your preferred vector: COQ4 (NM_016035)
    Sino Biological Human cDNA Clone for COQ4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COQ4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COQ4
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                         Customized lentivirus expression plasmids for stable overexpression of COQ4 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COQ4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    UniProtKB/Swiss-Prot: COQ4_HUMAN, Q9Y3A0
    Pathway: Cofactor biosynthesis; ubiquinone biosynthesis

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COQ4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/46 Interacting proteins for COQ4 (Q9Y3A03 ENSP000003004524) via UniProtKB, MINT, STRING, and/or I2D (see all 46)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006744ubiquinone biosynthetic process IEA--

    COQ4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for COQ4

    Search CenterWatch for drugs/clinical trials and news about COQ4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for COQ4 gene: 
    NM_016035.3  

    Unigene Cluster for COQ4:

    Coenzyme Q4 homolog (S. cerevisiae)
    Hs.98541  [show with all ESTs]
    Unigene Representative Sequence: AK128853
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300452(uc004bur.4 uc010mxy.3) ENST00000372875(uc011max.1)
    ENST00000461102
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COQ4
    1 QIAGEN miScript miRNA Assays for microRNA that regulate COQ4:
    hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmidCOQ4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for COQ4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COQ4
    Clone
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    OriGene clones in human, mouse for COQ4 (see all 7)
    OriGene ORF clones in mouse, rat for COQ4
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    GenScript: all cDNA clones in your preferred vector: COQ4 (NM_016035)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COQ4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COQ4
    Sirion Biotech Customized lentivirus for stable overexpression of COQ4 
                         Customized lentivirus expression plasmids for stable overexpression of COQ4 
    Primer
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    OriGene qPCR primer pairs and template standards for COQ4
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COQ4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COQ4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COQ4

    Additional mRNA sequence: 

    AF151850.1 AK025376.1 AK095083.1 AK126646.1 AK128853.1 AK301333.1 AK313650.1 BC011895.2 
    BC036603.1 EU216419.1 EU216420.1 EU216421.1 EU216422.1 EU216423.1 

    15 DOTS entries:

    DT.447450  DT.100823076  DT.91766403  DT.100823077  DT.99952460  DT.87046211  DT.99958266  DT.95150420 
    DT.97768658  DT.121166364  DT.91766402  DT.97855891  DT.100789460  DT.314672  DT.95263226 

    24/258 AceView cDNA sequences (see all 258):

    CR594347 AI424398 AU098700 AI199125 AI679953 BM766876 CD678629 CA306121 
    AI334189 AA443992 BI491484 BM784017 BF431886 AW300806 CR607746 BQ184310 
    BG680957 AA279332 BC011895 AI283627 CR601285 AI658532 BM756360 BQ575020 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for COQ4 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d
    SP1:                                                  -     -                 -     -           -     -     -     -           -                                 
    SP2:                          -     -     -           -     -                 -     -           -     -     -     -                                             
    SP3:                                                  -     -     -     -     -     -           -     -     -     -     -     -     -                           
    SP4:                                                  -     -                 -     -                                                                           
    SP5:                                                                                                                          -                                 


    ECgene alternative splicing isoforms for COQ4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COQ4 expression in normal human tissues (normalized intensities)      COQ4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGGATGTC
    COQ4 Expression
    About this image


    COQ4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   

    See COQ4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COQ4

    SOURCE GeneReport for Unigene cluster: Hs.98541

    UniProtKB/Swiss-Prot: COQ4_HUMAN, Q9Y3A0
    Tissue specificity: Expressed ubiquitously, but at high levels in liver, lung and pancreas

        SABiosciences Custom PCR Arrays for COQ4
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COQ4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COQ4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COQ4 gene from 10/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Coq41 , 5 coenzyme Q4 homolog (yeast)1, 5 81.64(n)1
    81.89(a)1
      2 (20.62 cM)5
    2276831  NM_178693.41  NP_848808.11 
     297874935 
    chicken
    (Gallus gallus)
    Aves COQ41 coenzyme Q4 homolog (S. cerevisiae) 69.14(n)
    69.92(a)
      417219  XM_415503.2  XP_415503.2 
    lizard
    (Anolis carolinensis)
    Reptilia COQ46
    Uncharacterized protein
    48(a)
    1 ↔ 1
    GL343763.1(329-5375)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.159212 Xenopus laevis transcribed sequence with moderate similarity more 74.33(n)    BJ040057.1 
    zebrafish
    (Danio rerio)
    Actinopterygii coq41 coenzyme Q4 homolog (S. cerevisiae) 61.63(n)
    69.33(a)
      100137123  NM_001114720.1  NP_001108192.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG321741 CG32174 53.59(n)
    46.84(a)
      261607  NM_168732.3  NP_730270.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T03F1.23
    coq-41
    Protein COQ-41 43(a)3
    48.2(n)1
    43.69(a)1
      I(3869223-3870888)3
    1719661  NM_058845.41  NP_491246.41 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes COQ4(YDR204W)4
    COQ41
    Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, more4
    Coq4p1
    47.23(n)1
    39.46(a)1
      4(858137-859144)4
    8517851, 4  NP_010490.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G036901 ubiquinone biosynthesis protein COQ4-like protein 46.54(n)
    41.01(a)
      814897  NM_126417.2  NP_178465.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g06742001 hypothetical protein 48.96(n)
    38.28(a)
      4337378  NM_001060772.1  NP_001054237.1 


    ENSEMBL Gene Tree for COQ4 (if available)
    TreeFam Gene Tree for COQ4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/370 SNPs in COQ4 are shown (see all 370)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0548614
    ----see VAR_0548612 G A mis40--------
    rs1411090871,2
    --131095365(+) TTTTAG/TTAGAG 1 -- us2k10--------
    rs1886586021,2
    C--131095404(+) GTCTCA/GAACTC 1 -- us2k10--------
    rs1498389551,2
    C--131095661(+) TTTTGA/GGACGG 1 -- us2k10--------
    rs1410299051,2
    C--131095712(+) TTCGG-/CTC   
       ACTGC
    AACCT
    1 -- us2k10--------
    rs1468497251,2
    --131095726(+) ACCTCC/TGCCTC 1 -- us2k10--------
    rs1811444771,2
    --131095786(+) CAGGCA/GCCTGC 1 -- us2k10--------
    rs1853376851,2
    --131095791(+) GCCTGC/TCACCA 1 -- us2k10--------
    rs1457907871,2
    --131095801(+) ACTCCC/TGGCTA 1 -- us2k10--------
    rs1386186341,2
    --131095891(+) TCCTCA/GGCCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for COQ4 (131084791 - 131096351 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for COQ4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831728CNV Loss17160897
    dgv8294n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): COQ4
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    COQ4 for disorders           About MalaCards
    OMIM gene information: 612898    OMIM disorders: --


    COQ4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): COQ4
    Human Genome Epidemiology (HuGE) Navigator: COQ4 (1 document)

    Export disorders for COQ4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COQ4 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with COQ4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    2. Functional characterization of human COQ4, a gene required for coenzyme Q10 biosynthesis. (PubMed id 18474229)1, 2 Casarin A.... Salviati L. (2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Yeast COQ4 encodes a mitochondrial protein required for coenzyme Q synthesis. (PubMed id 11469793)1, 3 Belogrudov G.I....Clarke C.F. (2001)
    5. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
    6. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    7. Haploinsufficiency of COQ4 causes coenzyme Q10 deficie ncy. (PubMed id 22368301)1 Salviati L....Navas P. (2012)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51117 HGNC: 19693 AceView: COQ4 Ensembl:ENSG00000167113 euGenes: HUgn51117
    ECgene: COQ4 H-InvDB: COQ4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COQ4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for COQ4 gene:
    Search GeneIP for patents involving COQ4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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