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Aliases for COQ3 Gene

Aliases for COQ3 Gene

  • Coenzyme Q3, Methyltransferase 2 3 5
  • Polyprenyldihydroxybenzoate Methyltransferase 2 3 4
  • 3-Demethylubiquinol 3-O-Methyltransferase 3 4
  • Hexaprenyldihydroxybenzoate Methyltransferase, Mitochondrial 3
  • Ubiquinone Biosynthesis O-Methyltransferase, Mitochondrial 3
  • Coenzyme Q3 Homolog, Methyltransferase (S. Cerevisiae) 2
  • 3,4-Dihydroxy-5-Hexaprenylbenzoate Methyltransferase 3
  • Coenzyme Q3 Homolog, Methyltransferase (Yeast) 2
  • Dihydroxyhexaprenylbenzoate Methyltransferase 3
  • 3-Demethylubiquinone-10 3-Methyltransferase 3
  • 2-Polyprenyl-6-Hydroxyphenol Methylase 3
  • 2-Polyprenyl-6-Hydroxyphenyl Methylase 3
  • Coenzyme Q3 Homolog, Methyltransferase 3
  • DHHB Methyltransferase 3
  • Methyltransferase COQ3 3
  • EC 2.1.1.114 4
  • EC 2.1.1.64 4
  • DHHB-MTase 3
  • DHHBMTASE 3
  • UG0215E05 3
  • BA9819.1 3
  • EC 2.1.1 61
  • DHHB-MT 3
  • DHHBMT 3

External Ids for COQ3 Gene

Previous GeneCards Identifiers for COQ3 Gene

  • GC06M099685
  • GC06M099833
  • GC06M099862
  • GC06M099923
  • GC06M099817
  • GC06M097257

Summaries for COQ3 Gene

Entrez Gene Summary for COQ3 Gene

  • Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.[supplied by OMIM, Mar 2008]

GeneCards Summary for COQ3 Gene

COQ3 (Coenzyme Q3, Methyltransferase) is a Protein Coding gene. Among its related pathways are Ubiquinol biosynthesis and Metabolism. GO annotations related to this gene include methyltransferase activity and S-adenosylmethionine-dependent methyltransferase activity.

UniProtKB/Swiss-Prot for COQ3 Gene

  • O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COQ3 Gene

Genomics for COQ3 Gene

Regulatory Elements for COQ3 Gene

Enhancers for COQ3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around COQ3 on UCSC Golden Path with GeneCards custom track

Promoters for COQ3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COQ3 on UCSC Golden Path with GeneCards custom track

Genomic Location for COQ3 Gene

Chromosome:
6
Start:
99,369,400 bp from pter
End:
99,394,218 bp from pter
Size:
24,819 bases
Orientation:
Minus strand

Genomic View for COQ3 Gene

Genes around COQ3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COQ3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COQ3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COQ3 Gene

Proteins for COQ3 Gene

  • Protein details for COQ3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZJ6-COQ3_HUMAN
    Recommended name:
    Ubiquinone biosynthesis O-methyltransferase, mitochondrial
    Protein Accession:
    Q9NZJ6
    Secondary Accessions:
    • B3KPX0
    • Q5T061
    • Q6P4F0
    • Q8IXG6
    • Q96BG1
    • Q9H0N1

    Protein attributes for COQ3 Gene

    Size:
    369 amino acids
    Molecular mass:
    41054 Da
    Quaternary structure:
    • Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
    SequenceCaution:
    • Sequence=AAF66826.1; Type=Frameshift; Positions=16, 18, 22, 26, 44, 49, 60, 363, 364; Evidence={ECO:0000305};

neXtProt entry for COQ3 Gene

Selected DME Specific Peptides for COQ3 Gene

Post-translational modifications for COQ3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COQ3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for COQ3 Gene

Protein Domains for COQ3 Gene

Suggested Antigen Peptide Sequences for COQ3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZJ6

UniProtKB/Swiss-Prot:

COQ3_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
genes like me logo Genes that share domains with COQ3: view

No data available for Gene Families for COQ3 Gene

Function for COQ3 Gene

Molecular function for COQ3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate.
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n.
UniProtKB/Swiss-Prot Function:
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

Enzyme Numbers (IUBMB) for COQ3 Gene

Gene Ontology (GO) - Molecular Function for COQ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004395 hexaprenyldihydroxybenzoate methyltransferase activity IEA --
GO:0008171 O-methyltransferase activity IGI 10777520
GO:0008425 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity IEA --
GO:0008689 3-demethylubiquinone-9 3-O-methyltransferase activity IEA --
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity IBA --
genes like me logo Genes that share ontologies with COQ3: view
genes like me logo Genes that share phenotypes with COQ3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for COQ3

CRISPR Products

miRNA for COQ3 Gene

miRTarBase miRNAs that target COQ3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COQ3 Gene

Localization for COQ3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COQ3 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COQ3 Gene COMPARTMENTS Subcellular localization image for COQ3 gene
Compartment Confidence
mitochondrion 5
nucleus 2
peroxisome 2
cytosol 1

Gene Ontology (GO) - Cellular Components for COQ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 10777520
GO:0005743 mitochondrial inner membrane IEA --
GO:0005759 mitochondrial matrix TAS --
GO:0031314 extrinsic component of mitochondrial inner membrane IEA --
genes like me logo Genes that share ontologies with COQ3: view

Pathways & Interactions for COQ3 Gene

genes like me logo Genes that share pathways with COQ3: view

Pathways by source for COQ3 Gene

UniProtKB/Swiss-Prot Q9NZJ6-COQ3_HUMAN

  • Pathway: Cofactor biosynthesis; ubiquinone biosynthesis.

Gene Ontology (GO) - Biological Process for COQ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006071 glycerol metabolic process IGI 10777520
GO:0006744 ubiquinone biosynthetic process TAS --
GO:0010795 regulation of ubiquinone biosynthetic process IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with COQ3: view

No data available for SIGNOR curated interactions for COQ3 Gene

Drugs & Compounds for COQ3 Gene

(4) Drugs for COQ3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
Ubiquinone-1 Experimental Pharma 0
Ubiquinone-2 Experimental Pharma 0

(11) Additional Compounds for COQ3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol
  • Demethyl-ubiquinol-6
2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone
2-Polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone
3-Demethylubiquinone-9
3-Hexaprenyl-4,5-Dihydroxybenzoic acid
  • 3,4-Dihydroxy-5-hexaprenylbenzoate
  • 3,4-Dihydroxy-5-hexaprenylbenzoic acid
  • 3-Hexaprenyl-4,5-Dihydroxybenzoate
  • 3-Hexaprenyl-4,5-Dihydroxybenzoic acid
  • Dhhpba
63975-40-6
genes like me logo Genes that share compounds with COQ3: view

Transcripts for COQ3 Gene

Unigene Clusters for COQ3 Gene

Coenzyme Q3 homolog, methyltransferase (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COQ3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: -
SP2:
SP3: - -
SP4: - -
SP5: - - - - - - -

Relevant External Links for COQ3 Gene

GeneLoc Exon Structure for
COQ3
ECgene alternative splicing isoforms for
COQ3

Expression for COQ3 Gene

mRNA expression in normal human tissues for COQ3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COQ3 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.2).

Protein differential expression in normal tissues from HIPED for COQ3 Gene

This gene is overexpressed in Heart (22.2), Breast (11.5), and Tonsil (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for COQ3 Gene



Protein tissue co-expression partners for COQ3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of COQ3 Gene:

COQ3

SOURCE GeneReport for Unigene cluster for COQ3 Gene:

Hs.713623
genes like me logo Genes that share expression patterns with COQ3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for COQ3 Gene

Orthologs for COQ3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COQ3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COQ3 34
  • 85.73 (n)
  • 81.03 (a)
COQ3 35
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COQ3 34
  • 86.21 (n)
  • 81.1 (a)
COQ3 35
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Coq3 34
  • 78.56 (n)
  • 73.02 (a)
Coq3 16
Coq3 35
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COQ3 34
  • 99.46 (n)
  • 98.37 (a)
COQ3 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Coq3 34
  • 83.57 (n)
  • 81.34 (a)
oppossum
(Monodelphis domestica)
Mammalia COQ3 35
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COQ3 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves COQ3 34
  • 70.14 (n)
  • 66.19 (a)
COQ3 35
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COQ3 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia coq3 34
  • 65.54 (n)
  • 61.42 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.22548 34
zebrafish
(Danio rerio)
Actinopterygii coq3 34
  • 61.15 (n)
  • 61.02 (a)
coq3 35
  • 50 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4935 34
fruit fly
(Drosophila melanogaster)
Insecta CG9249 36
  • 40 (a)
CG9249 34
  • 49.47 (n)
  • 42.06 (a)
CG9249 35
  • 35 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010537 34
  • 49.87 (n)
  • 46.4 (a)
worm
(Caenorhabditis elegans)
Secernentea coq-3 34
  • 47.68 (n)
  • 43.03 (a)
coq-3 35
  • 39 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR115W 34
  • 44.12 (n)
  • 36.93 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C03630g 34
  • 46.05 (n)
  • 36.44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COQ3 34
  • 45.49 (n)
  • 34.76 (a)
COQ3 35
  • 26 (a)
OneToOne
COQ3 37
thale cress
(Arabidopsis thaliana)
eudicotyledons COQ3 34
  • 51.42 (n)
  • 41.3 (a)
rice
(Oryza sativa)
Liliopsida Os06g0152300 34
  • 53.14 (n)
  • 46.03 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05982 34
  • 44.07 (n)
  • 36.54 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes coq3 34
  • 47.42 (n)
  • 38.49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToOne
Species where no ortholog for COQ3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COQ3 Gene

ENSEMBL:
Gene Tree for COQ3 (if available)
TreeFam:
Gene Tree for COQ3 (if available)

Paralogs for COQ3 Gene

No data available for Paralogs for COQ3 Gene

Variants for COQ3 Gene

Sequence variations from dbSNP and Humsavar for COQ3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs6925344 - 99,371,503(+) AATAC(C/G/T)TGCAA reference, missense
rs4144164 - 99,369,725(+) AGCAT(A/G)AGCTG reference, missense
rs11548336 - 99,377,472(-) TTCTG(A/G)AAACA reference, missense
rs4840035 -- 99,374,137(+) aaaaa(A/T)aaaaa intron-variant
rs4840036 -- 99,379,161(+) CCCTC(C/G)CCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COQ3 Gene

Variant ID Type Subtype PubMed ID
dgv1819e212 CNV loss 25503493
esv3571319 CNV loss 25503493
esv3890914 CNV loss 25118596
nsv1029536 CNV loss 25217958
nsv1117658 CNV deletion 24896259
nsv527517 CNV loss 19592680

Variation tolerance for COQ3 Gene

Residual Variation Intolerance Score: 87.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.82; 91.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COQ3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COQ3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COQ3 Gene

Disorders for COQ3 Gene

Relevant External Links for COQ3

Genetic Association Database (GAD)
COQ3
Human Genome Epidemiology (HuGE) Navigator
COQ3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COQ3

No disorders were found for COQ3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COQ3 Gene

Publications for COQ3 Gene

  1. Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis. (PMID: 10777520) Jonassen T. … Clarke C.F. (J. Biol. Chem. 2000) 2 3 4 22 65
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 65
  3. An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). (PMID: 19161160) Franke B. … Blom H.J. (Birth Defects Res. Part A Clin. Mol. Teratol. 2009) 3 46 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for COQ3 Gene

Sources for COQ3 Gene

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