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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COQ2 Gene

protein-coding   GIFtS: 57
GCID: GC04M084184

coenzyme Q2 homolog, prenyltransferase (yeast)

 Explore 10 diseases affiliated with
COQ2 via our new
 Human Malady Compendium 
Biological research products
for COQ2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Coenzyme Q2 Homolog, Prenyltransferase (Yeast)1 2     Para-Hydroxybenzoate-Polyprenyltransferase, Mitochondrial2
CL6401 2 3     EC 2.5.1.393
PHB:Polyprenyltransferase1     Para-Hydroxybenzoate--Polyprenyltransferase1
FLJ260721     COQ2 Homolog3
4-Hydroxybenzoate Polyprenyltransferase, Mitochondrial2     HCOQ21
COQ10D12     EC 2.5.18

External Ids:    HGNC: 252231   Entrez Gene: 272352   Ensembl: ENSG000001730857   OMIM: 6098255   UniProtKB: Q96H963   

Export aliases for COQ2 gene to outside databases

Previous GC identifers: GC04M084543 GC04M084404 GC04M079927


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COQ2:
This gene encodes an enzyme that functions in the final steps in the biosynthesis of CoQ (ubiquinone), a redox carrier
in the mitochondrial respiratory chain and a lipid-soluble antioxidant. This enzyme, which is part of the coenzyme Q10
pathway, catalyzes the prenylation of parahydroxybenzoate with an all-trans polyprenyl group. Mutations in this gene
cause coenzyme Q10 deficiency, a mitochondrial encephalomyopathy, and also COQ2 nephropathy, an inherited form of
mitochondriopathy with primary renal involvement. (provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: COQ2_HUMAN, Q96H96
Function: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the
second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the
polyisoprenoid side chain with PHB

Gene Wiki entry for COQ2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COQ2 gene promoter:
         Nkx3-1   Pax-6   Nkx3-1 v1   Tal-1beta   E47   N-Myc   FOXO4   FOXO1a   Msx-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOQ2 promoter sequence
   Search SABiosciences Chromatin IP Primers for COQ2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COQ2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.23   Ensembl cytogenetic band:  4q21.23   HGNC cytogenetic band: 4q21.23

COQ2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COQ2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M084184:  view genomic region     (about GC identifiers)

Start:
84,182,689 bp from pter      End:
84,206,067 bp from pter
Size:
23,379 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: COQ2_HUMAN, Q96H96 (See protein sequence)
Recommended Name: 4-hydroxybenzoate polyprenyltransferase, mitochondrial precursor  
Size: 371 amino acids; 40489 Da
Subcellular location: Mitochondrion membrane; Multi-pass membrane protein (Probable)
Sequence caution: Sequence=AAC72955.1; Type=Frameshift; Positions=172; Sequence=AAH20728.2; Type=Erroneous initiation;
Note=Translation N-terminally shortened; Sequence=CAF18241.1; Type=Erroneous initiation; Note=Translation N-terminally
shortened;
Secondary accessions: O95331 Q1JQ78 Q684R2
Alternative splicing: 2 isoforms:  Q96H96-1   Q96H96-3   

Explore the universe of human proteins at neXtProt for COQ2: NX_Q96H96

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96H96

  • 4/9 DME Specific Peptides for COQ2 (Q96H96) (see all 9)
     RTANRPI  PIGTWLL  FLGIVLG  RLDKPIG 

    COQ2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_056512.5  
    ENSEMBL proteins: 
     ENSP00000426242   ENSP00000427146   ENSP00000310873   ENSP00000311835   ENSP00000409275  
    Reactome Protein details: Q96H96
    Human Recombinant Protein Products: 
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    Uscn Proteins for COQ2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion RCA15153069
    GO:0016021integral to membrane RCA15153069
    GO:0031966mitochondrial membrane IEA--


    COQ2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    COQ2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR006370 HB_polyprenyl-transferase
     IPR000537 UbiA_prenyltransferase

    Graphical View of Domain Structure for InterPro Entry Q96H96

    ProtoNet protein and cluster: Q96H96

    1 Blocks protein family: IPB000537 UbiA prenyltransferase

    UniProtKB/Swiss-Prot: COQ2_HUMAN, Q96H96
    Similarity: Belongs to the UbiA prenyltransferase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: COQ2_HUMAN, Q96H96
    Function: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the
    second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the
    polyisoprenoid side chain with PHB
    Catalytic activity: A polyprenyl diphosphate + 4-hydroxybenzoate = diphosphate + a 4-hydroxy-3-polyprenylbenzoate

    Enzyme Numbers (IUBMB): EC 2.5.1.391 EC 2.5.12

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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00020834-hydroxybenzoate decaprenyltransferase activity IEA--
    GO:0004659prenyltransferase activity ----
    GO:00472934-hydroxybenzoate nonaprenyltransferase activity IEA--


    COQ2 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Metabolism
    Metabolism1.00
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.38
    2Ubiquinone and other terpenoid-quinone biosynthesis
    Ubiquinone and other terpenoid-quinone biosynthesis1.00
    Ubiquinol biosynthesis0.56
    3Mitochondrial Protein Import
    Mitochondrial Protein Import1.00
    4Asparagine N-linked glycosylation
    Metabolism of proteins0.15

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for COQ2
        Metabolism
    Mitochondrial Protein Import
    Ubiquinol biosynthesis
    Metabolism of proteins
    Metabolism of lipids and lipoproteins


    2         Kegg Pathways  (Kegg details for COQ2):
        Ubiquinone and other terpenoid-quinone biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: COQ2_HUMAN, Q96H96
    Pathway: Cofactor biosynthesis; ubiquinone biosynthesis


    COQ2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COQ2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/52 Interacting proteins for COQ2 (Q96H963 ENSP000004092754) via UniProtKB, MINT, STRING, and/or I2D (see all 52)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDAP323203, ENSP000003642124I2D: score=1 STRING: ENSP00000364212
    FHP079543, ENSP000003555184I2D: score=1 STRING: ENSP00000355518
    HSPD1P108093, ENSP000003400194I2D: score=1 STRING: ENSP00000340019
    SACM1LQ9NTJ53, ENSP000003737134I2D: score=1 STRING: ENSP00000373713
    ACO2Q997983, ENSP000002162544I2D: score=1 STRING: ENSP00000216254
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006071glycerol metabolic process IGI15153069
    GO:0006744ubiquinone biosynthetic process IEA--
    GO:0008299isoprenoid biosynthetic process IEA--
    GO:0009058biosynthetic process ----


    COQ2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    COQ2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for COQ2

    2 HMDB Compounds for COQ2    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-hexaprenyl-4-hydroxybenzoic acid3-Hexaprenyl-4-hydroxybenzoate (see all 4)65848-03-5--
    4-Hydroxybenzoic acid4-Carboxyphenol (see all 14)99-96-7--
    3 Novoseek chemical compound relationships for COQ2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    coq1 93.1 2 8405427 (1), 16863505 (1)
    coq10 89.4 4 19096106 (1), 17485248 (1)
    ubiquinone 80.5 4 19096106 (1), 17332895 (1), 15153069 (1)

    3 PharmGKB related drug/compound annotations for COQ2 gene
    Drug/compound PharmGKB Annotation
    atorvastatinCA  
    hmg coa reductase inhibitorsCA  
    rosuvastatinCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about COQ2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for COQ2 gene: 
    NM_015697.7  

    Unigene Clusters for COQ2:

    Coenzyme Q2 homolog, prenyltransferase (yeast)
    Hs.144304  [show with all ESTs], Hs.729069  [show with all ESTs]
    Unigene Representative Sequences: AK023076, AJ621061
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503391(uc011ccp.2) ENST00000503915(uc003hof.3) ENST00000311469(uc003hog.3)
    ENST00000311461 ENST00000514935 ENST00000439031

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    Additional cDNA sequence: 

    AF091086.1 AJ621061.3 AK129583.1 AK300972.1 BC008804.2 BC020728.1 BC116454.1 CR456860.1 

    5 DOTS entries:

    DT.92425603  DT.101977783  DT.412556  DT.70101912  DT.75112790 

    24/113 AceView cDNA sequences (see all 113):

    AA761131 CR597797 BM126596 CD674223 BU784581 CB152084 AI141143 AA825250 
    CB528537 AA027943 N62617 CR604430 CR598020 AI300528 AW103157 BX092802 
    AW074420 CA444596 BM987067 BM126855 AL558750 BC020728 BX387830 BG699931 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for COQ2    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                  -               
    SP2:                                                                  
    SP3:                                                                  


    ECgene alternative splicing isoforms for COQ2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COQ2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTTGGTTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See COQ2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COQ2

    SOURCE GeneReport for Unigene clusters: Hs.144304 Hs.729069

    UniProtKB/Swiss-Prot: COQ2_HUMAN, Q96H96
    Tissue specificity: Widely expressed. Present in all of the tissues tested. Expressed at higher level in skeletal
    muscle, adrenal glands and the heart

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COQ2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for COQ2 gene from 11/36 species (see all 36)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Coq21 , 5 coenzyme Q2 homolog, prenyltransferase (yeast)1, 5 80.33(n)1
    81.72(a)1
      5 (48.50 cM)5
    718831  NM_027978.21  NP_082254.21 
     1006547235 
    chicken
    (Gallus gallus)
    Aves COQ21 coenzyme Q2 homolog, prenyltransferase (yeast) 68.64(n)
    72.49(a)
      422605  XM_420564.3  XP_420564.2 
    lizard
    (Anolis carolinensis)
    Reptilia COQ26
    --
    73(a)
    1 ↔ 1
    5(43275517-43290406)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.165652 Xenopus laevis transcribed sequence with weak similarity more 76.33(n)    BJ059744.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.99052 Transcribed sequence with weak similarity to protein more 75.35(n)    BI326122.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Coq21 Coenzyme Q biosynthesis protein 2 57.88(n)
    64.73(a)
      40988  NM_141532.2  NP_649789.1 
    worm
    (Caenorhabditis elegans)
    Secernentea coq-21 Protein COQ-2 57.01(n)
    57.24(a)
      175969  NM_066112.3  NP_498513.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes COQ2(YNR041C)4
    COQ21
    Para hydroxybenzoate: polyprenyl transferase, catalyzes more4
    Coq2p1
    50.31(n)1
    47.6(a)1
      14(701659-700541)4
    8557781, 4  NP_014439.31  NP_014439.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PPT11 polyprenyltransferase 1 57.36(n)
    60.42(a)
      828466  NM_001203886.1  NP_001190815.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g03226001 hypothetical protein 55.56(n)
    58.25(a)
      4345268  NM_001068074.1  NP_001061539.1 


    ENSEMBL Gene Tree for COQ2 (if available)
    TreeFam Gene Tree for COQ2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): COQ2
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    COQ2 for disorders           About GeneDecksing

    OMIM gene information: 609825   
    OMIM disorders: 607426  
    UniProtKB/Swiss-Prot: COQ2_HUMAN, Q96H96
  • Defects in COQ2 are the cause of coenzyme Q10 deficiency, primary, type 1 (COQ10D1) [MIM:607426]. An autosomal
  • recessive disorder with variable manifestations consistent with 5 major phenotypes. The phenotypes include an
    encephalomyopathic form with seizures and ataxia; a multisystem infantile form with encephalopathy, cardiomyopathy and
    renal failure; a predominantly cerebellar form with ataxia and cerebellar atrophy; Leigh syndrome with growth
    retardation; and an isolated myopathic form

    10 diseases for COQ2:    About MalaCards
    encephalomyopathy    nephropathy    dna topoisomerase ii    mitochondrial encephalomyopathy
    cerebellar ataxia    leigh disease    nephrotic syndrome    ataxia
    pharyngitis    malaria

    2 diseases from the University of Copenhagen DISEASES database for COQ2:
    Cerebellar ataxia     Leigh disease

    1 Novoseek disease relationship for COQ2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    coenzyme q10 deficiency 91.6 1 16400613 (1)

    Human Genome Epidemiology (HuGE) Navigator: COQ2 (2 documents)

    Export disorders for COQ2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COQ2 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with COQ2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ2. (PubMed id 15153069)1, 2, 3, 9 Forsgren M.... Climent I. (2004)
    2. A mutation in para-hydroxybenzoate-polyprenyl transferase (COQ2) causes primary coenzyme Q10 deficiency. (PubMed id 16400613)1, 2, 9 Quinzii C....Hirano M. (2006)
    3. COQ2 nephropathy: a newly described inherited mitochondriopathy with primary renal involvement. (PubMed id 17855635)1, 2 Diomedi-Camassei F....Emma F. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Respiratory chain dysfunction and oxidative stress correlate with severity of primary CoQ10 deficiency. (PubMed id 18230681)1, 9 Quinzii C.M....Hirano M. (2008)
    6. Prenyldiphosphate synthase, subunit 1 (PDSS1) and OH-benzoate polyprenyltransferase (COQ2) mutations in ubiquinone deficiency and oxidative phosphorylation disorders. (PubMed id 17332895)1, 9 Mollet J.... Rotig A. (2007)
    7. Human CoQ10 deficiencies. (PubMed id 19096106)1, 9 Quinzii C.M....Hirano M. (2008)
    8. Clinical, biochemical and molecular aspects of cerebellar ataxia and Coenzyme Q10 deficiency. (PubMed id 17510911)1, 9 Montero R....Artuch R. (2007)
    9. Heterogeneity of coenzyme Q10 deficiency: patient stud y and literature review. (PubMed id 22490322)1 Emmanuele V....Hirano M. (2012)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27235 HGNC: 25223 AceView: CL640 Ensembl:ENSG00000173085 euGenes: HUgn27235
    ECgene: COQ2 Kegg: 27235 H-InvDB: COQ2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COQ2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for COQ2 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/COQ2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for COQ2 gene:
    Search GeneIP for patents involving COQ2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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