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Aliases for COQ10B Gene

Aliases for COQ10B Gene

  • Coenzyme Q10B 2 3
  • Coenzyme Q10 Homolog B (S. Cerevisiae) 2
  • Coenzyme Q10 Homolog B (Yeast) 2

External Ids for COQ10B Gene

Previous GeneCards Identifiers for COQ10B Gene

  • GC02P198144
  • GC02P198026
  • GC02P198318
  • GC02P190170

Summaries for COQ10B Gene

GeneCards Summary for COQ10B Gene

COQ10B (Coenzyme Q10B) is a Protein Coding gene. An important paralog of this gene is COQ10A.

UniProtKB/Swiss-Prot for COQ10B Gene

  • Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COQ10B Gene

Genomics for COQ10B Gene

Regulatory Elements for COQ10B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COQ10B Gene

Chromosome:
2
Start:
197,453,423 bp from pter
End:
197,475,308 bp from pter
Size:
21,886 bases
Orientation:
Plus strand

Genomic View for COQ10B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COQ10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COQ10B Gene

Proteins for COQ10B Gene

  • Protein details for COQ10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8M1-CQ10B_HUMAN
    Recommended name:
    Coenzyme Q-binding protein COQ10 homolog B, mitochondrial
    Protein Accession:
    Q9H8M1
    Secondary Accessions:
    • B7Z1Y4

    Protein attributes for COQ10B Gene

    Size:
    238 amino acids
    Molecular mass:
    27071 Da
    Quaternary structure:
    • Interacts with coenzyme Q.

    Alternative splice isoforms for COQ10B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COQ10B Gene

Proteomics data for COQ10B Gene at MOPED

Post-translational modifications for COQ10B Gene

  • Ubiquitination at Lys 144
  • Modification sites at PhosphoSitePlus

Other Protein References for COQ10B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for COQ10B Gene

Domains & Families for COQ10B Gene

Protein Domains for COQ10B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H8M1

UniProtKB/Swiss-Prot:

CQ10B_HUMAN :
  • Belongs to the COQ10 family.
Family:
  • Belongs to the COQ10 family.
genes like me logo Genes that share domains with COQ10B: view

No data available for Gene Families for COQ10B Gene

Function for COQ10B Gene

Molecular function for COQ10B Gene

UniProtKB/Swiss-Prot Function:
Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity).

Phenotypes for COQ10B Gene

genes like me logo Genes that share phenotypes with COQ10B: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COQ10B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for COQ10B Gene

Localization for COQ10B Gene

Subcellular locations from UniProtKB/Swiss-Prot for COQ10B Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COQ10B Gene COMPARTMENTS Subcellular localization image for COQ10B gene
Compartment Confidence
mitochondrion 3
cytosol 2

Gene Ontology (GO) - Cellular Components for COQ10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
genes like me logo Genes that share ontologies with COQ10B: view

Pathways & Interactions for COQ10B Gene

SuperPathways for COQ10B Gene

No Data Available

Interacting Proteins for COQ10B Gene

Gene Ontology (GO) - Biological Process for COQ10B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for COQ10B Gene

Drugs & Compounds for COQ10B Gene

No Compound Related Data Available

Transcripts for COQ10B Gene

Unigene Clusters for COQ10B Gene

Coenzyme Q10 homolog B (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COQ10B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COQ10B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - - -
SP3: - -
SP4:

Relevant External Links for COQ10B Gene

GeneLoc Exon Structure for
COQ10B
ECgene alternative splicing isoforms for
COQ10B

Expression for COQ10B Gene

mRNA expression in normal human tissues for COQ10B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for COQ10B Gene

This gene is overexpressed in Frontal cortex (12.2), Heart (8.5), and Bone (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COQ10B Gene



SOURCE GeneReport for Unigene cluster for COQ10B Gene Hs.606592

genes like me logo Genes that share expression patterns with COQ10B: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for COQ10B Gene

Orthologs for COQ10B Gene

This gene was present in the common ancestor of animals.

Orthologs for COQ10B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COQ10B 35
  • 88.94 (n)
  • 89.5 (a)
COQ10B 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COQ10B 35
  • 90.62 (n)
  • 91.18 (a)
mouse
(Mus musculus)
Mammalia Coq10b 35
  • 83.61 (n)
  • 84.87 (a)
Coq10b 16
Coq10b 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COQ10B 35
  • 99.58 (n)
  • 99.58 (a)
COQ10B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Coq10b 35
  • 84.31 (n)
  • 85.71 (a)
oppossum
(Monodelphis domestica)
Mammalia COQ10B 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COQ10B 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves COQ10B 35
  • 73.94 (n)
  • 76.42 (a)
COQ10B 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COQ10B 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia coq10a 35
  • 68.63 (n)
  • 75.49 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14965 35
zebrafish
(Danio rerio)
Actinopterygii coq10b 35
  • 64.22 (n)
  • 70.69 (a)
coq10b 36
  • 68 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007391 35
  • 50.46 (n)
  • 51.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9410 35
  • 49.44 (n)
  • 52.35 (a)
CG9410 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R144.13 36
  • 45 (a)
OneToMany
Species with no ortholog for COQ10B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COQ10B Gene

ENSEMBL:
Gene Tree for COQ10B (if available)
TreeFam:
Gene Tree for COQ10B (if available)

Paralogs for COQ10B Gene

Paralogs for COQ10B Gene

(1) SIMAP similar genes for COQ10B Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for COQ10B Gene

genes like me logo Genes that share paralogs with COQ10B: view

Variants for COQ10B Gene

Sequence variations from dbSNP and Humsavar for COQ10B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs11070 -- 197,475,052(-) AAAAA(C/T)ACCAG utr-variant-3-prime
rs787990 -- 197,460,266(+) GCGCA(A/G)TCTTG intron-variant
rs787991 -- 197,460,395(+) ACTGT(A/G)TTGGC intron-variant
rs934186 -- 197,464,096(+) ataca(C/T)atata intron-variant
rs1864284 -- 197,463,964(+) AAAAA(A/T)ATATA intron-variant

Variation tolerance for COQ10B Gene

Residual Variation Intolerance Score: 45.71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COQ10B Gene

HapMap Linkage Disequilibrium report
COQ10B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for COQ10B Gene

Disorders for COQ10B Gene

Relevant External Links for COQ10B

Genetic Association Database (GAD)
COQ10B
Human Genome Epidemiology (HuGE) Navigator
COQ10B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COQ10B
genes like me logo Genes that share disorders with COQ10B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COQ10B Gene

Publications for COQ10B Gene

  1. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 67
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 67
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 67
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 67
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 67

Products for COQ10B Gene

Sources for COQ10B Gene

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