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Aliases for COQ10B Gene

Aliases for COQ10B Gene

  • Coenzyme Q10B 2 3 5
  • Coenzyme Q10 Homolog B (S. Cerevisiae) 2
  • Coenzyme Q10 Homolog B (Yeast) 2

External Ids for COQ10B Gene

Previous GeneCards Identifiers for COQ10B Gene

  • GC02P198144
  • GC02P198026
  • GC02P198318
  • GC02P190170

Summaries for COQ10B Gene

GeneCards Summary for COQ10B Gene

COQ10B (Coenzyme Q10B) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. An important paralog of this gene is COQ10A.

UniProtKB/Swiss-Prot for COQ10B Gene

  • Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COQ10B Gene

Genomics for COQ10B Gene

Regulatory Elements for COQ10B Gene

Enhancers for COQ10B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G197203 1.8 FANTOM5 Ensembl ENCODE dbSUPER 8.9 -242.1 -242138 15.7 HDGF PKNOX1 FOXA2 WRNIP1 YY1 TCF12 GATA2 FOS JUNB TBX21 ANKRD44 ANKRD44-IT1 LOC105373824 MOB4 COQ10B SF3B1 MARS2 HSPD1 LOC105373826 LOC101927596
GH02G197292 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.4 -157.8 -157773 6.7 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 BMI1 ZBTB7B CBX5 ZNF207 RELB ANKRD44 LOC101927596 COQ10B SF3B1 MOB4 ANKRD44-IT1 GC02P197264
GH02G197252 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4.8 -197.0 -197017 7.4 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 CBX5 ZNF143 ZNF207 FOS RELB ANKRD44 ANKRD44-IT1 LOC105373824 LOC101927596 COQ10B SF3B1 ATP5G2P3 GC02P197242
GH02G197451 1.4 ENCODE dbSUPER 5.6 0.0 -45 4.2 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 HSPE1 HSPD1 ENSG00000202434 BOLL ANKRD44 PLCL1 COQ10B RNU6-1029P
GH02G197157 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4.4 -293.8 -293839 3.5 ELF3 HDGF FOXA2 ZSCAN4 ZBTB40 RARA YY1 GATA2 FOS IKZF2 ANKRD44 ANKRD44-IT1 LOC105373824 COQ10B SF3B1 GC02P197128 LOC101927596
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around COQ10B on UCSC Golden Path with GeneCards custom track

Promoters for COQ10B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000128439 277 2201 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX CREB3L1 WRNIP1 ARID4B SIN3A FEZF1

Genomic Location for COQ10B Gene

Chromosome:
2
Start:
197,453,423 bp from pter
End:
197,475,308 bp from pter
Size:
21,886 bases
Orientation:
Plus strand

Genomic View for COQ10B Gene

Genes around COQ10B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COQ10B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COQ10B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COQ10B Gene

Proteins for COQ10B Gene

  • Protein details for COQ10B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8M1-CQ10B_HUMAN
    Recommended name:
    Coenzyme Q-binding protein COQ10 homolog B, mitochondrial
    Protein Accession:
    Q9H8M1
    Secondary Accessions:
    • B7Z1Y4

    Protein attributes for COQ10B Gene

    Size:
    238 amino acids
    Molecular mass:
    27071 Da
    Quaternary structure:
    • Interacts with coenzyme Q.

    Alternative splice isoforms for COQ10B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COQ10B Gene

Post-translational modifications for COQ10B Gene

  • Ubiquitination at isoforms=2144
  • Modification sites at PhosphoSitePlus

Other Protein References for COQ10B Gene

No data available for DME Specific Peptides for COQ10B Gene

Domains & Families for COQ10B Gene

Protein Domains for COQ10B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H8M1

UniProtKB/Swiss-Prot:

CQ10B_HUMAN :
  • Belongs to the COQ10 family.
Family:
  • Belongs to the COQ10 family.
genes like me logo Genes that share domains with COQ10B: view

No data available for Gene Families for COQ10B Gene

Function for COQ10B Gene

Molecular function for COQ10B Gene

UniProtKB/Swiss-Prot Function:
Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity).

Gene Ontology (GO) - Molecular Function for COQ10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048039 ubiquinone binding IBA --
genes like me logo Genes that share ontologies with COQ10B: view
genes like me logo Genes that share phenotypes with COQ10B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COQ10B Gene

Localization for COQ10B Gene

Subcellular locations from UniProtKB/Swiss-Prot for COQ10B Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COQ10B gene
Compartment Confidence
mitochondrion 4
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for COQ10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with COQ10B: view

Pathways & Interactions for COQ10B Gene

genes like me logo Genes that share pathways with COQ10B: view

Interacting Proteins for COQ10B Gene

Gene Ontology (GO) - Biological Process for COQ10B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006744 ubiquinone biosynthetic process IBA --
GO:0045333 cellular respiration IBA --
genes like me logo Genes that share ontologies with COQ10B: view

No data available for SIGNOR curated interactions for COQ10B Gene

Drugs & Compounds for COQ10B Gene

No Compound Related Data Available

Transcripts for COQ10B Gene

Unigene Clusters for COQ10B Gene

Coenzyme Q10 homolog B (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for COQ10B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - - -
SP3: - -
SP4:

Relevant External Links for COQ10B Gene

GeneLoc Exon Structure for
COQ10B
ECgene alternative splicing isoforms for
COQ10B

Expression for COQ10B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COQ10B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for COQ10B Gene

This gene is overexpressed in Frontal cortex (12.2), Heart (8.5), and Bone (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for COQ10B Gene



NURSA nuclear receptor signaling pathways regulating expression of COQ10B Gene:

COQ10B

SOURCE GeneReport for Unigene cluster for COQ10B Gene:

Hs.606592

Evidence on tissue expression from TISSUES for COQ10B Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with COQ10B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for COQ10B Gene

Orthologs for COQ10B Gene

This gene was present in the common ancestor of animals.

Orthologs for COQ10B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COQ10B 34 35
  • 99.58 (n)
dog
(Canis familiaris)
Mammalia COQ10B 34
  • 90.62 (n)
cow
(Bos Taurus)
Mammalia COQ10B 34 35
  • 88.94 (n)
oppossum
(Monodelphis domestica)
Mammalia COQ10B 35
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Coq10b 34
  • 84.31 (n)
mouse
(Mus musculus)
Mammalia Coq10b 34 16 35
  • 83.61 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia COQ10B 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves COQ10B 34 35
  • 73.94 (n)
lizard
(Anolis carolinensis)
Reptilia COQ10B 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia coq10a 34
  • 68.63 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14965 34
zebrafish
(Danio rerio)
Actinopterygii coq10b 34 35
  • 64.22 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007391 34
  • 50.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9410 34 35
  • 49.44 (n)
worm
(Caenorhabditis elegans)
Secernentea R144.13 35
  • 45 (a)
OneToMany
Species where no ortholog for COQ10B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COQ10B Gene

ENSEMBL:
Gene Tree for COQ10B (if available)
TreeFam:
Gene Tree for COQ10B (if available)

Paralogs for COQ10B Gene

Paralogs for COQ10B Gene

(1) SIMAP similar genes for COQ10B Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for COQ10B Gene

genes like me logo Genes that share paralogs with COQ10B: view

Variants for COQ10B Gene

Sequence variations from dbSNP and Humsavar for COQ10B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000169732 -- 197,464,876(+) AAATC(C/T)TTTTT intron-variant
rs1000222941 -- 197,461,161(+) GTTAA(C/G)GTAAT intron-variant
rs1000455801 -- 197,468,163(+) AGGCC(-/GG)GTGTG intron-variant
rs1000493945 -- 197,463,417(+) AGTGT(G/T)CCGAG intron-variant
rs1000831245 -- 197,467,882(+) TTTTC(-/AG)AGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COQ10B Gene

Variant ID Type Subtype PubMed ID
nsv1014881 CNV gain 25217958

Variation tolerance for COQ10B Gene

Residual Variation Intolerance Score: 45.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COQ10B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COQ10B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COQ10B Gene

Disorders for COQ10B Gene

Relevant External Links for COQ10B

Genetic Association Database (GAD)
COQ10B
Human Genome Epidemiology (HuGE) Navigator
COQ10B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COQ10B

No disorders were found for COQ10B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COQ10B Gene

Publications for COQ10B Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 64
  5. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3 64

Products for COQ10B Gene

Sources for COQ10B Gene

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