COQ10B Gene
protein-coding GIFtS: 44
GCID: GC02P198318
|
|
coenzyme Q10 homolog B (S. cerevisiae)(Previous name: coenzyme Q10 homolog B (yeast) )
| |
Aliases
for COQ10B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coenzyme Q10 Homolog B (S. Cerevisiae)1 2 | | FLJ134481 | | Coenzyme Q10 Homolog B (Yeast)1 | | Coenzyme Q-Binding Protein COQ10 Homolog B, Mitochondrial2 |
Export aliases for COQ10B gene to outside databasesPrevious GC identifers: GC02P198144 GC02P198026 GC02P190170 |
Summaries
for COQ10B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CQ10B_HUMAN, Q9H8M1Function: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involvedin the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity)
|
Genomic Views
for COQ10B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the COQ10B gene promoter:
STAT1 AML1a STAT4 Brachyury Bach2 STAT1beta STAT1alpha CREB STAT2 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for COQ10B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COQ10B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q33.1 Ensembl cytogenetic band: 2q33.1 HGNC cytogenetic band: 2q33.1COQ10B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P198318: view genomic region
(about GC identifiers)
Start:
|
198,318,147 bp from pter |
End:
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198,340,032 bp from pter |
Size:
|
21,886 bases |
Orientation:
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plus strand |
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Proteins
for COQ10B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CQ10B_HUMAN, Q9H8M1 (See
protein sequence)Recommended Name: Coenzyme Q-binding protein COQ10 homolog B, mitochondrial precursor Size: 238 amino acids; 27071 Da
Subunit: Interacts with coenzyme Q (By similarity)
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity)Explore the universe of human proteins at neXtProt for COQ10B: NX_Q9H8M1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H8M1
COQ10B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079423.1
ENSEMBL proteins: ENSP00000263960 ENSP00000386785 ENSP00000387223 ENSP00000442520
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
-- | -- | | GO:0005743 | mitochondrial inner membrane |
IEA | -- |
COQ10B for ontologies About GeneDecksing
COQ10B Antibody Products:
Assay Products for COQ10B: |
Protein
Domains /
Families
for COQ10B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
COQ10B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H8M1ProtoNet protein and cluster: Q9H8M1 UniProtKB/Swiss-Prot: CQ10B_HUMAN, Q9H8M1Similarity: Belongs to the COQ10 family |
Function
for COQ10B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CQ10B_HUMAN, Q9H8M1Function: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involvedin the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COQ10B (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COQ10B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COQ10B |
1 GenomeRNAi human phenotype for COQ10B:
|
Pathways & Interactions
for COQ10B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COQ10B
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for COQ10B (ENSP000002639604) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for COQ10B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for COQ10B
Search CenterWatch for drugs/clinical trials and news about COQ10B / CQ10B
|
Transcripts
for COQ10B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for COQ10B gene: NM_025147.3 Unigene Cluster for COQ10B: Coenzyme Q10 homolog B (S. cerevisiae) Hs.606592 [show with all ESTs]Unigene Representative Sequence: AK0963095 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000263960(uc002uuh.1 uc010fsl.1) ENST00000409398 ENST00000488445
ENST00000409010 ENST00000545340
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COQ10B (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COQ10B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: COQ10B (NM_025147) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COQ10B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COQ10B |
Additional cDNA sequence: AK023510.1 AK096309.1 AK294093.1 AK308977.1 BC022453.1 4 DOTS entries: DT.95375605 DT.97842333 DT.75119073 DT.100024460 24/99 AceView cDNA sequences (see all 99): BP375243 BU782617 AK096309 BP343774 BU517346 AI610678 NM_025147 BM479944 AA232326 BU521741 BI835671 BM818285 BQ010248 BM744220 AI948661 AA339812 BM769921 AV660489 BC022453 BI549772 BU173190 BP344877 AA442174 BP343246
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for COQ10B About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for COQ10B
|
Expression
for COQ10B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| COQ10B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTCTTCTGA
About this image
See COQ10B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COQ10B
SOURCE GeneReport for Unigene cluster: Hs.606592
SABiosciences Custom PCR Arrays for COQ10B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COQ10B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COQ10B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COQ10B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COQ10B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COQ10B |
Orthologs
for COQ10B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for COQ10B gene from 9/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
COQ10B1 |
coenzyme Q10 homolog B (S. cerevisiae) |
73.94(n)
76.42(a) |
|
424057 XM_421913.3 XP_421913.1 |
lizard
(Anolis carolinensis) |
Reptilia |
COQ10B6 |
-- |
78(a) |
1 ↔ 1 |
GL343436.1(710088-714514) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.149652 |
Xenopus laevis transcribed sequence with moderate similarity more |
75.54(n) |
|
BU914274.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
coq10b1 |
coenzyme Q10 homolog B (S. cerevisiae) |
64.22(n)
70.69(a) |
|
550442 NM_001017747.1 NP_001017747.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG159081 |
CG15908 |
49.44(n)
52.35(a) |
|
35567 NM_165481.4 NP_724484.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
R144.136 |
Protein R144.13 |
45(a) |
1 → many |
III(5023285-5024031) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT4G176506 |
Polyketide cyclase / dehydrase and lipid transport... |
27(a) |
1 → many |
4(9827515-9829659) |
rice
(Oryza sativa) |
Liliopsida |
-- |
cyclase/dehydrase family protein, expressed |
28(a) |
1 → many |
1(32607637-32610001) |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
ratA6 |
toxic protein, UPF0083 family |
24(a) |
possible ortholog |
Chromosome(2752310-2752786) |
ENSEMBL Gene Tree for COQ10B (if available)
TreeFam Gene Tree for COQ10B (if available) |
Paralogs
for COQ10B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for COQ10B gene
- COQ10A2
1 SIMAP similar gene for COQ10B using alignment to 4 protein entries: CQ10B_HUMAN (see all proteins):COQ10A
COQ10B for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for COQ10B
PGOHUM00000238373 PGOHUM00000235300
|
Genomic Variants
for COQ10B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for COQ10B (198318147 - 198340032 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for COQ10B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COQ10B |
|
Disorders
/ Diseases
for COQ10B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
COQ10B for disorders About GeneDecksing
1  disease for COQ10B: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: COQ10B (1 document)
Export disorders for COQ10B gene to outside databases
|
Publications
for COQ10B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for COQ10B gene integrated from 9 sources:
(articles sorted by number of sources associating them with COQ10B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for COQ10B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing COQ10B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing COQ10B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COQ10B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for COQ10B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for COQ10B gene:
Search GeneIP for patents involving COQ10B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for COQ10B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for COQ10B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COQ10B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COQ10B | | | OriGene Protein Over-expression Lysate for COQ10B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for COQ10B | | OriGene 3'-UTR Clone for COQ10B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COQ10B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COQ10B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for COQ10B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COQ10B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COQ10B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COQ10B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COQ10B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COQ10B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COQ10B |
| |
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| |  |  |  |  | | | | |
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 |
 | | | COQ10B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COQ10B |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COQ10B |
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