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Aliases for COQ10A Gene

Aliases for COQ10A Gene

  • Coenzyme Q10A 2 3 5
  • Coenzyme Q10 Homolog A (S. Cerevisiae) 2
  • Coenzyme Q10 Homolog A (Yeast) 2

External Ids for COQ10A Gene

Previous GeneCards Identifiers for COQ10A Gene

  • GC12P054947
  • GC12P056660
  • GC12P053700

Summaries for COQ10A Gene

GeneCards Summary for COQ10A Gene

COQ10A (Coenzyme Q10A) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. An important paralog of this gene is COQ10B.

UniProtKB/Swiss-Prot for COQ10A Gene

  • Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (Probable).

Additional gene information for COQ10A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COQ10A Gene

Genomics for COQ10A Gene

Regulatory Elements for COQ10A Gene

Enhancers for COQ10A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H056298 1.4 ENCODE dbSUPER 10.8 +34.0 33953 4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 BAZ2A ZC3H10 NEMP1 RN7SL809P CDK2 DNAJC14 RPL41 MMP19 ENSG00000257303 TMEM198B
GH12H056124 1.4 ENCODE dbSUPER 10.2 -138.9 -138863 6 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 ZNF610 NEMP1 BAZ2A SMARCC2 DNAJC14 MYL6 PYM1 ENSG00000258199 RN7SL809P ZBTB39 ZC3H10
GH12H056196 1.1 Ensembl ENCODE 11.6 -69.8 -69809 1 INSM2 KLF17 FEZF1 ZNF2 ZEB1 ZNF366 ZNF362 TSHZ1 ZEB2 ZNF645 SMARCC2 OR10A7 OR6C74 NABP2 RNF41 SLC39A5 ANKRD52 COQ10A ENSG00000258199 ENSG00000257740
GH12H056206 0.8 ENCODE 11.7 -59.4 -59379 1 HDGF CTCF TSC22D4 ARID4B ZNF2 RAD21 ZEB1 CTBP1 POLR2A SCRT2 SLC39A5 ANKRD52 COQ10A CS ZC3H10 RPL41 RPS26 MYL6B RNF41 GC12P056196
GH12H056291 0.7 ENCODE 12.5 +24.8 24752 1 PKNOX1 NFIB CTBP1 GATA3 SCRT2 FOSL2 FOS ZNF600 TCF7L2 SCRT1 COQ10A ANKRD52 SLC39A5 NABP2 RNF41 PAN2 IL23A APOF GC12P056293 GC12M056288
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around COQ10A on UCSC Golden Path with GeneCards custom track

Promoters for COQ10A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052497 342 1201 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143

Genomic Location for COQ10A Gene

Chromosome:
12
Start:
56,266,858 bp from pter
End:
56,270,966 bp from pter
Size:
4,109 bases
Orientation:
Plus strand

Genomic View for COQ10A Gene

Genes around COQ10A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COQ10A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COQ10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COQ10A Gene

Proteins for COQ10A Gene

  • Protein details for COQ10A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MF6-CQ10A_HUMAN
    Recommended name:
    Coenzyme Q-binding protein COQ10 homolog A, mitochondrial
    Protein Accession:
    Q96MF6
    Secondary Accessions:
    • Q6GMR6
    • Q6UWB9
    • Q86X16
    • Q8TAL2
    • Q96MF1
    • Q9BUP4

    Protein attributes for COQ10A Gene

    Size:
    247 amino acids
    Molecular mass:
    27686 Da
    Quaternary structure:
    • Interacts with coenzyme Q.
    SequenceCaution:
    • Sequence=AAH26922.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAQ89220.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for COQ10A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COQ10A Gene

Post-translational modifications for COQ10A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COQ10A Gene

No data available for DME Specific Peptides for COQ10A Gene

Domains & Families for COQ10A Gene

Gene Families for COQ10A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for COQ10A Gene

Suggested Antigen Peptide Sequences for COQ10A Gene

Graphical View of Domain Structure for InterPro Entry

Q96MF6

UniProtKB/Swiss-Prot:

CQ10A_HUMAN :
  • Belongs to the COQ10 family.
Family:
  • Belongs to the COQ10 family.
genes like me logo Genes that share domains with COQ10A: view

Function for COQ10A Gene

Molecular function for COQ10A Gene

UniProtKB/Swiss-Prot Function:
Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (Probable).

Phenotypes From GWAS Catalog for COQ10A Gene

Gene Ontology (GO) - Molecular Function for COQ10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048039 ubiquinone binding IBA --
genes like me logo Genes that share ontologies with COQ10A: view
genes like me logo Genes that share phenotypes with COQ10A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for COQ10A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for COQ10A Gene

Localization for COQ10A Gene

Subcellular locations from UniProtKB/Swiss-Prot for COQ10A Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COQ10A gene
Compartment Confidence
mitochondrion 4
cytosol 2
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Endoplasmic reticulum (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for COQ10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with COQ10A: view

Pathways & Interactions for COQ10A Gene

genes like me logo Genes that share pathways with COQ10A: view

Interacting Proteins for COQ10A Gene

Gene Ontology (GO) - Biological Process for COQ10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006744 ubiquinone biosynthetic process IBA --
GO:0045333 cellular respiration IBA --
genes like me logo Genes that share ontologies with COQ10A: view

No data available for SIGNOR curated interactions for COQ10A Gene

Drugs & Compounds for COQ10A Gene

No Compound Related Data Available

Transcripts for COQ10A Gene

Unigene Clusters for COQ10A Gene

Coenzyme Q10 homolog A (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for COQ10A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for COQ10A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: -
SP7: - - -
SP8: -

Relevant External Links for COQ10A Gene

GeneLoc Exon Structure for
COQ10A
ECgene alternative splicing isoforms for
COQ10A

Expression for COQ10A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COQ10A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COQ10A Gene

This gene is overexpressed in Heart - Left Ventricle (x9.6), Muscle - Skeletal (x6.6), and Heart - Atrial Appendage (x4.5).

Protein differential expression in normal tissues from HIPED for COQ10A Gene

This gene is overexpressed in Heart (34.3) and Tonsil (25.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for COQ10A Gene



Protein tissue co-expression partners for COQ10A Gene

NURSA nuclear receptor signaling pathways regulating expression of COQ10A Gene:

COQ10A

SOURCE GeneReport for Unigene cluster for COQ10A Gene:

Hs.4096

Evidence on tissue expression from TISSUES for COQ10A Gene

  • Muscle(4.5)
  • Nervous system(4.5)
  • Intestine(4.2)
  • Skin(4.1)
  • Blood(3)
genes like me logo Genes that share expression patterns with COQ10A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for COQ10A Gene

Orthologs for COQ10A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COQ10A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COQ10A 33 34
  • 99.73 (n)
rat
(Rattus norvegicus)
Mammalia Coq10a 33
  • 91.58 (n)
dog
(Canis familiaris)
Mammalia COQ10A 33 34
  • 89.96 (n)
cow
(Bos Taurus)
Mammalia COQ10A 33 34
  • 89.81 (n)
mouse
(Mus musculus)
Mammalia Coq10a 33 16 34
  • 88.53 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia COQ10A 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves COQ10A 33
  • 73.54 (n)
lizard
(Anolis carolinensis)
Reptilia COQ10A 34
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3699 33
zebrafish
(Danio rerio)
Actinopterygii COQ10A (2 of 2) 34
  • 71 (a)
OneToMany
LOC100333108 33
  • 62.45 (n)
COQ10A (1 of 2) 34
  • 61 (a)
OneToMany
Dr.12531 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9902 33
fruit fly
(Drosophila melanogaster)
Insecta CG9410 34
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R144.13 33 34
  • 50.46 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G17650 33
  • 48.99 (n)
rice
(Oryza sativa)
Liliopsida Os01g0772400 33
  • 50.41 (n)
Species where no ortholog for COQ10A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COQ10A Gene

ENSEMBL:
Gene Tree for COQ10A (if available)
TreeFam:
Gene Tree for COQ10A (if available)

Paralogs for COQ10A Gene

Paralogs for COQ10A Gene

(1) SIMAP similar genes for COQ10A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with COQ10A: view

Variants for COQ10A Gene

Sequence variations from dbSNP and Humsavar for COQ10A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000240518 -- 56,270,533(+) AGGGT(A/C)AGGCC utr-variant-3-prime
rs1000357140 -- 56,270,861(+) GGAGA(A/G)AAGTA utr-variant-3-prime
rs1000601372 -- 56,266,848(+) GTTGT(C/T)CCCTT upstream-variant-2KB
rs1001542559 -- 56,271,390(+) TAGAC(C/G)AGTTC downstream-variant-500B
rs1001608063 -- 56,270,732(+) TGCCT(-/GAGATTCCTCAG)GAGAA cds-indel

Structural Variations from Database of Genomic Variants (DGV) for COQ10A Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV gain+loss 15286789

Variation tolerance for COQ10A Gene

Residual Variation Intolerance Score: 40.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.62; 56.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COQ10A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COQ10A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COQ10A Gene

Disorders for COQ10A Gene

Relevant External Links for COQ10A

Genetic Association Database (GAD)
COQ10A
Human Genome Epidemiology (HuGE) Navigator
COQ10A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COQ10A

No disorders were found for COQ10A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COQ10A Gene

Publications for COQ10A Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 60

Products for COQ10A Gene

Sources for COQ10A Gene

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