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Aliases for COQ10A Gene

Aliases for COQ10A Gene

  • Coenzyme Q10 Homolog A (S. Cerevisiae) 2 3
  • Coenzyme Q10 Homolog A (Yeast) 2

External Ids for COQ10A Gene

Summaries for COQ10A Gene

GeneCards Summary for COQ10A Gene

COQ10A (Coenzyme Q10 Homolog A (S. Cerevisiae)) is a Protein Coding gene. An important paralog of this gene is COQ10B.

UniProtKB/Swiss-Prot for COQ10A Gene

  • Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (Probable).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COQ10A Gene

Genomics for COQ10A Gene

Genomic Location for COQ10A Gene

Start:
56,266,858 bp from pter
End:
56,270,966 bp from pter
Size:
4,109 bases
Orientation:
Plus strand

Genomic View for COQ10A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COQ10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COQ10A Gene

Regulatory Elements for COQ10A Gene

Proteins for COQ10A Gene

  • Protein details for COQ10A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MF6-CQ10A_HUMAN
    Recommended name:
    Coenzyme Q-binding protein COQ10 homolog A, mitochondrial
    Protein Accession:
    Q96MF6
    Secondary Accessions:
    • Q6GMR6
    • Q6UWB9
    • Q86X16
    • Q8TAL2
    • Q96MF1
    • Q9BUP4

    Protein attributes for COQ10A Gene

    Size:
    247 amino acids
    Molecular mass:
    27686 Da
    Quaternary structure:
    • Interacts with coenzyme Q.
    SequenceCaution:
    • Sequence=AAH26922.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAQ89220.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for COQ10A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COQ10A Gene

Proteomics data for COQ10A Gene at MOPED

Post-translational modifications for COQ10A Gene

No Post-translational modifications

Other Protein References for COQ10A Gene

No data available for DME Specific Peptides for COQ10A Gene

Domains for COQ10A Gene

Protein Domains for COQ10A Gene

UniProtKB/Swiss-Prot:

CQ10A_HUMAN
Family:
  • Belongs to the COQ10 family.:
    • Q96MF6
genes like me logo Genes that share domains with COQ10A: view

No data available for Gene Families for COQ10A Gene

Function for COQ10A Gene

Molecular function for COQ10A Gene

UniProtKB/Swiss-Prot Function: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (Probable).

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for COQ10A Gene

Localization for COQ10A Gene

Subcellular locations from UniProtKB/Swiss-Prot for COQ10A Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COQ10A Gene COMPARTMENTS Subcellular localization image for COQ10A gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for COQ10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
genes like me logo Genes that share ontologies with COQ10A: view

Pathways for COQ10A Gene

SuperPathways for COQ10A Gene

No Data Available

Interacting Proteins for COQ10A Gene

Gene Ontology (GO) - Biological Process for COQ10A Gene

None

No data available for Pathways by source for COQ10A Gene

Transcripts for COQ10A Gene

Unigene Clusters for COQ10A Gene

Coenzyme Q10 homolog A (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COQ10A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: -
SP7: - - -
SP8: -

Relevant External Links for COQ10A Gene

GeneLoc Exon Structure for
COQ10A
ECgene alternative splicing isoforms for
COQ10A

Expression for COQ10A Gene

mRNA expression in normal human tissues for COQ10A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COQ10A Gene

This gene is overexpressed in Heart - Left Ventricle (9.6), Muscle - Skeletal (6.6), and Heart - Atrial Appendage (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for COQ10A Gene

SOURCE GeneReport for Unigene cluster for COQ10A Gene Hs.4096

genes like me logo Genes that share expressions with COQ10A: view

Orthologs for COQ10A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COQ10A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COQ10A 36
  • 99.73 (n)
  • 99.6 (a)
COQ10A 37
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COQ10A 36
  • 89.81 (n)
  • 88.02 (a)
COQ10A 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COQ10A 36
  • 89.96 (n)
  • 90.38 (a)
COQ10A 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Coq10a 36
  • 88.53 (n)
  • 90.28 (a)
Coq10a 16
Coq10a 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COQ10A 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Coq10a 36
  • 91.58 (n)
  • 96.53 (a)
chicken
(Gallus gallus)
Aves COQ10A 36
  • 73.54 (n)
  • 81.87 (a)
lizard
(Anolis carolinensis)
Reptilia COQ10A 37
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3699 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9902 36
zebrafish
(Danio rerio)
Actinopterygii COQ10A (1 of 2) 37
  • 61 (a)
OneToMany
COQ10A (2 of 2) 37
  • 71 (a)
OneToMany
Dr.12531 36
LOC100333108 36
  • 62.45 (n)
  • 66.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9410 37
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R144.13 36
  • 50.46 (n)
  • 45.89 (a)
R144.13 37
  • 42 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G17650 36
  • 48.99 (n)
  • 40.94 (a)
rice
(Oryza sativa)
Liliopsida Os01g0772400 36
  • 50.41 (n)
  • 40.24 (a)
Species with no ortholog for COQ10A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COQ10A Gene

ENSEMBL:
Gene Tree for COQ10A (if available)
TreeFam:
Gene Tree for COQ10A (if available)

Paralogs for COQ10A Gene

Paralogs for COQ10A Gene

Selected SIMAP similar genes for COQ10A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with COQ10A: view

Variants for COQ10A Gene

Sequence variations from dbSNP and Humsavar for COQ10A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs773651 -- 56,271,104(-) AGAAT(A/G)TGCTA downstream-variant-500B
rs1045224 -- 56,270,914(+) TTATT(C/T)TTCCA utr-variant-3-prime
rs1274498 -- 56,266,909(-) CTCGG(C/T)ACCCC upstream-variant-2KB, utr-variant-5-prime
rs1274499 -- 56,266,627(-) ggaca(G/T)agtga upstream-variant-2KB
rs1274500 -- 56,265,075(-) ATAAA(A/C)GTCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for COQ10A Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV Complex 15286789

Relevant External Links for COQ10A Gene

HapMap Linkage Disequilibrium report
COQ10A

Disorders for COQ10A Gene

Relevant External Links for COQ10A

Genetic Association Database (GAD)
COQ10A
Human Genome Epidemiology (HuGE) Navigator
COQ10A
genes like me logo Genes that share disorders with COQ10A: view

No data available for UniProtKB/Swiss-Prot for COQ10A Gene

Publications for COQ10A Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  5. Rosuvastatin combined with regular exercise preserves coenzyme Q10 levels associated with a significant increase in high-density lipoprotein cholesterol in patients with coronary artery disease. (PMID: 21458815) Toyama K. … Ogawa H. (Atherosclerosis 2011) 3

Products for COQ10A Gene

Sources for COQ10A Gene

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