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COQ10A Gene

protein-coding   GIFtS: 44
GCID: GC12P056660

Coenzyme Q10 Homolog A (S. Cerevisiae)

(Previous name: coenzyme Q10 homolog A (yeast))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coenzyme Q10 Homolog A (S. Cerevisiae)1 2
Coenzyme Q10 Homolog A (Yeast)1
Coenzyme Q-Binding Protein COQ10 Homolog A, Mitochondrial2

External Ids:    HGNC: 265151   Entrez Gene: 930582   Ensembl: ENSG000001354697   UniProtKB: Q96MF63   

Export aliases for COQ10A gene to outside databases

Previous GC identifers: GC12P054947 GC12P053700


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for COQ10A Gene:
COQ10A (coenzyme Q10 homolog A (S. cerevisiae)) is a protein-coding gene. Diseases associated with COQ10A include familial hypercholesterolemia, and hypercholesterolemia. An important paralog of this gene is COQ10B.

UniProtKB/Swiss-Prot: CQ10A_HUMAN, Q96MF6
Function: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be
involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes
(Probable)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the COQ10A gene promoter:
         ER-alpha   TBP   GR   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOQ10A promoter sequence
   Search Chromatin IP Primers for COQ10A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COQ10A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.3

COQ10A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COQ10A gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P056660:  view genomic region     (about GC identifiers)

Start:
56,660,642 bp from pter      End:
56,664,750 bp from pter
Size:
4,109 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CQ10A_HUMAN, Q96MF6 (See protein sequence)
Recommended Name: Coenzyme Q-binding protein COQ10 homolog A, mitochondrial precursor  
Size: 247 amino acids; 27686 Da
Subunit: Interacts with coenzyme Q (By similarity)
Sequence caution: Sequence=AAH26922.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAQ89220.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6GMR6 Q6UWB9 Q86X16 Q8TAL2 Q96MF1 Q9BUP4
Alternative splicing: 3 isoforms:  Q96MF6-1   Q96MF6-2   Q96MF6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for COQ10A: NX_Q96MF6

Explore proteomics data for COQ10A at MOPED


See COQ10A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001092807.1  NP_653177.3  

ENSEMBL proteins: 
 ENSP00000312587   ENSP00000407843   ENSP00000446723   ENSP00000446957   ENSP00000447964  

COQ10A Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for COQ10A

COQ10A Antibody Products:

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COQ10A Assay Products:

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GenScript Custom Assay Services for COQ10A
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Cloud-Clone Corp. ELISAs for COQ10A
Cloud-Clone Corp. CLIAs for COQ10A


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR005031 Polyket_cyc
 IPR023393 START-like_dom

Graphical View of Domain Structure for InterPro Entry Q96MF6

ProtoNet protein and cluster: Q96MF6

1 Blocks protein domain: IPB005031 Streptomyces cyclase/dehydrase

UniProtKB/Swiss-Prot: CQ10A_HUMAN, Q96MF6
Similarity: Belongs to the COQ10 family


COQ10A for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CQ10A_HUMAN, Q96MF6
Function: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be
involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes
(Probable)

Animal Models:

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COQ10A
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for COQ10A

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COQ10A
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COQ10A

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat COQ10A using miScript Target Protectors
7 qRT-PCR Assays for microRNAs that regulate COQ10A:
hsa-miR-3163 hsa-miR-548d-3p hsa-miR-548am hsa-miR-377 hsa-miR-548x hsa-miR-590-3p hsa-miR-340
SwitchGear 3'UTR luciferase reporter plasmidCOQ10A 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for COQ10A
Predesigned siRNA for gene silencing in human, mouse, rat COQ10A

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for COQ10A

Clone
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OriGene clones in human, mouse for COQ10A (see all 12)
OriGene ORF clones in mouse, rat for COQ10A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): COQ10A (NM_001099337)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for COQ10A
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COQ10A

Cell Line
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GenScript Custom overexpressing Cell Line Services for COQ10A
Browse ESI BIO Cell Lines and PureStem Progenitors for COQ10A 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COQ10A


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CQ10A_HUMAN, Q96MF6: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
cytosol2
nucleus1
peroxisome1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005743mitochondrial inner membrane IEA--

COQ10A for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for COQ10A
Interactions:

    Search GeneGlobe Interaction Network for COQ10A

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

Selected Interacting proteins for COQ10A (Q96MF62 ENSP000003125874) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
InteractantInteraction Details
GeneCardExternal ID(s)
NHP2ENSP000002746064STRING: ENSP00000274606
COQ2ENSP000004092754STRING: ENSP00000409275
COQ7ENSP000003223164STRING: ENSP00000322316
ADCK3ENSP000003557394STRING: ENSP00000355739
ADCK4ENSP000003151184STRING: ENSP00000315118
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for COQ10A (CQ10A)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for COQ10A gene (2 alternative transcripts): 
NM_001099337.1  NM_144576.3  

Unigene Cluster for COQ10A:

Coenzyme Q10 homolog A (S. cerevisiae)
Hs.4096  [show with all ESTs]
Unigene Representative Sequence: NM_144576
10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000308197(uc001sko.4) ENST00000551566 ENST00000551911 ENST00000433805(uc001skp.4)
ENST00000550071 ENST00000546614 ENST00000546544(uc001skq.4) ENST00000553234
ENST00000549545 ENST00000551814
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat COQ10A using miScript Target Protectors
7 qRT-PCR Assays for microRNAs that regulate COQ10A:
hsa-miR-3163 hsa-miR-548d-3p hsa-miR-548am hsa-miR-377 hsa-miR-548x hsa-miR-590-3p hsa-miR-340
SwitchGear 3'UTR luciferase reporter plasmidCOQ10A 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for COQ10A
Predesigned siRNA for gene silencing in human, mouse, rat COQ10A
Clone
Products:
     
OriGene clones in human, mouse for COQ10A (see all 12)
OriGene ORF clones in mouse, rat for COQ10A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): COQ10A (NM_001099337)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for COQ10A
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COQ10A
Primer
Products:
    
OriGene qPCR primer pairs and template standards for COQ10A
OriGene qSTAR qPCR primer pairs in human, mouse for COQ10A
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COQ10A
  QuantiTect SYBR Green Assays in human, mouse, rat COQ10A
  QuantiFast Probe-based Assays in human, mouse, rat COQ10A

Additional mRNA sequence: 

AK057003.1 AK057014.1 AY358861.1 BC002435.2 BC026922.1 BC047444.1 BC073923.1 

10 DOTS entries:

DT.454513  DT.97838198  DT.87015080  DT.95371798  DT.100711716  DT.91908238  DT.99994396  DT.121203424 
DT.100771658  DT.95371794 

Selected AceView cDNA sequences (see all 163):

BU690048 AI185902 AI083874 CR592454 BC073923 CR594850 AA809993 CR591134 
CA449301 BM903862 AA907400 H79102 AA921965 BQ439789 AW673468 CR600865 
AA490214 AI205529 BC002435 BQ723100 AA063489 BE275272 AI039337 BQ954720 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for COQ10A (see all 8)    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c
SP1:                    -     -     -           -     -     -     -           -                           
SP2:                                -           -     -     -     -           -                           
SP3:                                            -     -     -     -           -                           
SP4:                    -     -     -           -     -     -                                             
SP5:                                -           -     -     -     -                                       


ECgene alternative splicing isoforms for COQ10A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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COQ10A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTGCCTGGCT
COQ10A Expression
About this image


COQ10A expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Adipose (Muscoskeletal System)
         Thoracic Perivascular Adipose
 
 Skeletal Muscle (Muscoskeletal System)
COQ10A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

COQ10A Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.4096
    Custom PCR Arrays for COQ10A
Primer
Products:
OriGene qPCR primer pairs and template standards for COQ10A
OriGene qSTAR qPCR primer pairs in human, mouse for COQ10A
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COQ10A
QuantiTect SYBR Green Assays in human, mouse, rat COQ10A
QuantiFast Probe-based Assays in human, mouse, rat COQ10A
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COQ10A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for COQ10A gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Coq10a1 , 5 coenzyme Q10 homolog A (yeast)1, 5 88.53(n)1
90.28(a)1
  10 (76.53 cM)5
2105821  NM_001081040.11  NP_001074509.11 
 1283630975 
chicken
(Gallus gallus)
Aves COQ10A1 coenzyme Q10 homolog A (S. cerevisiae) 73.54(n)
81.87(a)
  770970  XM_001234287.3  XP_001234288.3 
lizard
(Anolis carolinensis)
Reptilia COQ10A6
coenzyme Q10 homolog A (S. cerevisiae)
68(a)
1 ↔ 1
2(93620758-93636797)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.36992 Transcribed sequence with moderate similarity to protein more 76.56(n)    141998386 
zebrafish
(Danio rerio)
Actinopterygii Dr.125312 Transcribed sequence with moderate similarity to protein more 77.44(n)    AL915277.1 
fruit fly
(Drosophila melanogaster)
Insecta CG94106
--
34(a)
1 → many
2R(2556529-2557581)
worm
(Caenorhabditis elegans)
Secernentea R144.131 R144.13 50.46(n)
45.89(a)
  4363058  NM_001047401.1  NP_001040866.1 
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G176501 AT4G17650 48.99(n)
40.94(a)
  827485  NM_117873.3  NP_193500.1 
rice
(Oryza sativa)
Liliopsida Os01g07724001 Os01g0772400 50.41(n)
40.24(a)
  4324708  NM_001050926.1  NP_001044391.1 


ENSEMBL Gene Tree for COQ10A (if available)
TreeFam Gene Tree for COQ10A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for COQ10A gene
COQ10B2  
1 SIMAP similar gene for COQ10A using alignment to 3 protein entries:     CQ10A_HUMAN (see all proteins):
COQ10B

COQ10A for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for COQ10A (see all 137)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs599173081,2
C--56658708(+) CACCAC/TGCCCG 1 -- us2k10--------
rs1868781081,2
--56658776(+) TCGATC/TTCCTG 1 -- us2k10--------
rs12745001,2
C,F,A,H--56658859(-) ATAAAA/CGTCAG 1 -- us2k114Minor allele frequency- C:0.07NS EA NA 1816
rs1912910971,2
--56659290(+) GGGTTG/TCTGTC 2 -- us2k10--------
rs766745291,2
--56659299(+) TCCATA/GAGGTC 2 -- us2k10--------
rs761511701,2
C--56659320(+) TCAAGC/TGCACA 2 -- us2k14Minor allele frequency- T:0.06CSA WA NA EA 359
rs1903038161,2
--56659593(+) AAAGTA/GTTGTT 2 -- us2k10--------
rs1448087671,2
--56659655(+) GACTGG/TAAGGA 2 -- us2k10--------
rs1821403781,2
--56659662(+) AGGAAA/GTGACC 2 -- us2k10--------
rs1852049821,2
--56659733(+) GCTAGC/GCATGG 2 -- us2k10--------

HapMap Linkage Disequilibrium report for COQ10A (56660642 - 56664750 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for COQ10A:    About this table    
Variant IDTypeSubtypePubMed ID
nsv482992CNV Complex15286789

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing COQ10A
DNA2.0 Custom Variant and Variant Library Synthesis for COQ10A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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3 diseases for COQ10A:    
About MalaCards
familial hypercholesterolemia    hypercholesterolemia    coronary artery disease


COQ10A for disorders           About GeneDecksing

Genetic Association Database (GAD): COQ10A
Human Genome Epidemiology (HuGE) Navigator: COQ10A (1 document)

Export disorders for COQ10A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for COQ10A gene, integrated from 10 sources (see all 13):
(articles sorted by number of sources associating them with COQ10A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
  5. Coenzyme Q10 deficiency in children: frequent type 2C muscle fibers with normal morphology. (PubMed id 23494902)1 Sommerville R.B....Pestronk A. (amp 2013)
  6. The relationship between coenzyme Q10, oxidative stress, and antioxidant enzymes activities and coronary artery disease. (PubMed id 22645453)1 Lee B.J....Lin P.T. (ScientificWorldJournal 2012)
  7. Relationship between plasma coenzyme Q10, asymmetric dimethylarginine and arterial stiffness in patients with phenotypic or genotypic familial hypercholesterolemia on long-term statin therapy. (PubMed id 21640350)1 Young J.M....George P.M. (Atherosclerosis 2011)
  8. Rosuvastatin combined with regular exercise preserves coenzyme Q10 levels associated with a significant increase in high-density lipoprotein cholesterol in patients with coronary artery disease. (PubMed id 21458815)1 Toyama K....Ogawa H. (Atherosclerosis 2011)
  9. Effects of acetylsalicylic acid on serum paraoxonase activity, Ox-LDL, coenzyme Q10 and other oxidative stress markers in healthy volunteers. (PubMed id 19891963)1 Kurban S. and Mehmetoglu I. (Clin. Biochem. 2010)
  10. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 93058 HGNC: 26515 AceView: FLJ32452 Ensembl:ENSG00000135469 euGenes: HUgn93058
ECgene: COQ10A H-InvDB: COQ10A

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for COQ10A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for COQ10A gene:
Search GeneIP for patents involving COQ10A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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