COQ10A Gene
protein-coding GIFtS: 45
GCID: GC12P056660
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coenzyme Q10 homolog A (S. cerevisiae)(Previous name: coenzyme Q10 homolog A (yeast) )
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Aliases
for COQ10A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coenzyme Q10 Homolog A (S. Cerevisiae)1 2 | | FLJ324521 | | Coenzyme Q10 Homolog A (Yeast)1 | | Coenzyme Q-Binding Protein COQ10 Homolog A, Mitochondrial2 |
Export aliases for COQ10A gene to outside databasesPrevious GC identifers: GC12P054947 GC12P053700 |
Summaries
for COQ10A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CQ10A_HUMAN, Q96MF6Function: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involvedin the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (Probable)
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Genomic Views
for COQ10A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the COQ10A gene promoter:
ER-alpha TBP GR GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for COQ10A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COQ10A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.3 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q13.3COQ10A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P056660: view genomic region
(about GC identifiers)
Start:
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56,660,642 bp from pter |
End:
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56,664,750 bp from pter |
Size:
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4,109 bases |
Orientation:
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plus strand |
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Proteins
for COQ10A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CQ10A_HUMAN, Q96MF6 (See
protein sequence)Recommended Name: Coenzyme Q-binding protein COQ10 homolog A, mitochondrial precursor Size: 247 amino acids; 27686 Da
Subunit: Interacts with coenzyme Q (By similarity)
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity)
Sequence caution: Sequence=AAQ89220.1; Type=Erroneous initiation;
Secondary accessions: Q6GMR6 Q6UWB9 Q86X16 Q96MF1 Q9BUP4Alternative splicing: 2 isoforms: Q96MF6-1 Q96MF6-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for COQ10A: NX_Q96MF6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96MF6
COQ10A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001092807.1 NP_653177.3
ENSEMBL proteins: ENSP00000312587 ENSP00000407843 ENSP00000446723 ENSP00000446957 ENSP00000447964
Human Recombinant Protein Products for COQ10A:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005743 | mitochondrial inner membrane |
IEA | -- |
COQ10A for ontologies About GeneDecksing
COQ10A Antibody Products:
Assay Products for COQ10A: |
Protein
Domains /
Families
for COQ10A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
COQ10A for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96MF6ProtoNet protein and cluster: Q96MF6 1 Blocks protein family: IPB005031 Streptomyces cyclase/dehydrase
UniProtKB/Swiss-Prot: CQ10A_HUMAN, Q96MF6Similarity: Belongs to the COQ10 family |
Function
for COQ10A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CQ10A_HUMAN, Q96MF6Function: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involvedin the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (Probable)Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COQ10A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COQ10A (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): COQ10A (NM_001099337) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COQ10A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COQ10A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COQ10A |
|
Pathways & Interactions
for COQ10A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COQ10A
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for COQ10A (Q96MF62 ENSP000003125874) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for COQ10A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for COQ10A
Search CenterWatch for drugs/clinical trials and news about COQ10A / CQ10A
|
Transcripts
for COQ10A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for COQ10A gene (2 alternative transcripts): NM_001099337.1 NM_144576.3 Unigene Cluster for COQ10A: Coenzyme Q10 homolog A (S. cerevisiae) Hs.4096 [show with all ESTs]Unigene Representative Sequence: NM_14457610 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000308197(uc001sko.4) ENST00000551566 ENST00000551911 ENST00000433805(uc001skp.4)
ENST00000550071 ENST00000546614 ENST00000546544(uc001skq.4) ENST00000553234
ENST00000549545 ENST00000551814
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COQ10A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COQ10A (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): COQ10A (NM_001099337) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COQ10A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COQ10A |
Additional cDNA sequence: AK057003.1 AK057014.1 AY358861.1 BC002435.2 BC026922.1 BC047444.1 BC073923.1 10 DOTS entries: DT.454513 DT.97838198 DT.87015080 DT.95371798 DT.100711716 DT.91908238 DT.99994396 DT.121203424 DT.100771658 DT.95371794 24/163 AceView cDNA sequences (see all 163): AY358861 BE275272 BC073923 AA459698 BQ268825 BQ439789 BQ723100 AA063489 BF847942 BQ446304 AA459818 BC026922 BU690048 AA809993 CR594850 CA390205 BC002435 CR626666 AA921965 CA449301 AK057014 AI868424 BQ954720 BM903862
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for COQ10A (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
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| SP1: | | | | | | | - | | - | | - | | | | - | | - | | - | | - | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | - | | - | | - | | - | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for COQ10A
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Expression
for COQ10A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| COQ10A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCCTGGCT
About this image
See COQ10A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COQ10A
SOURCE GeneReport for Unigene cluster: Hs.4096
SABiosciences Custom PCR Arrays for COQ10A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COQ10A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COQ10A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COQ10A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COQ10A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COQ10A |
Orthologs
for COQ10A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for COQ10A gene from 10/26 species (see all 26) About this table
ENSEMBL Gene Tree for COQ10A (if available)
TreeFam Gene Tree for COQ10A (if available) |
Paralogs
for COQ10A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for COQ10A gene
- COQ10B2
1 SIMAP similar gene for COQ10A using alignment to 4 protein entries: CQ10A_HUMAN (see all proteins):COQ10B
COQ10A for paralogs About GeneDecksing
|
Genomic Variants
for COQ10A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for COQ10A (56660642 - 56664750 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for COQ10A
1 CNV: 0164 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COQ10A |
|
Disorders
/ Diseases
for COQ10A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
COQ10A for disorders About GeneDecksing
1  disease for COQ10A: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: COQ10A (1 document)
Export disorders for COQ10A gene to outside databases
|
Publications
for COQ10A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for COQ10A gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with COQ10A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- The relationship between coenzyme Q10, oxidative stres s, and antioxidant enzymes activities and coronary artery disease. (PubMed id 22645453)1 Lee B.J....Lin P.T. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Relationship between plasma coenzyme Q10, asymmetric d imethylarginine and arterial stiffness in patients with phenotypic or genotypic familial hypercholesterolemia on long-term statin therapy. (PubMed id 21640350)1 Young J.M....George P.M. (2011)
- Rosuvastatin combined with regular exercise preserves coenzyme Q10 levels associated with a significant increase in high-density lipop rotein cholesterol in patients with coronary artery disease. (PubMed id 21458815)1 Toyama K....Ogawa H. (2011)
- Effects of acetylsalicylic acid on serum paraoxonase activity, Ox-LDL, coenzyme Q10 and other oxidative stress markers in healthy vo lunteers. (PubMed id 19891963)1 Kurban S. and Mehmetoglu I. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for COQ10A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing COQ10A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing COQ10A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COQ10A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for COQ10A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for COQ10A gene:
Search GeneIP for patents involving COQ10A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for COQ10A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COQ10A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COQ10A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COQ10A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COQ10A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COQ10A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COQ10A |
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| |  |  |  |  | | | | |
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 | | | COQ10A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COQ10A |
|  |  |  |  | | | | Search ThermoFisher Antibodies for COQ10A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COQ10A |
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