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Aliases for COQ10A Gene

Aliases for COQ10A Gene

  • Coenzyme Q10A 2 3
  • Coenzyme Q10 Homolog A (S. Cerevisiae) 2
  • Coenzyme Q10 Homolog A (Yeast) 2

External Ids for COQ10A Gene

Previous GeneCards Identifiers for COQ10A Gene

  • GC12P054947
  • GC12P056660
  • GC12P053700

Summaries for COQ10A Gene

GeneCards Summary for COQ10A Gene

COQ10A (Coenzyme Q10A) is a Protein Coding gene. An important paralog of this gene is COQ10B.

UniProtKB/Swiss-Prot for COQ10A Gene

  • Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (Probable).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COQ10A Gene

Genomics for COQ10A Gene

Regulatory Elements for COQ10A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COQ10A Gene

56,266,858 bp from pter
56,270,966 bp from pter
4,109 bases
Plus strand

Genomic View for COQ10A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COQ10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COQ10A Gene

Proteins for COQ10A Gene

  • Protein details for COQ10A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coenzyme Q-binding protein COQ10 homolog A, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q6GMR6
    • Q6UWB9
    • Q86X16
    • Q8TAL2
    • Q96MF1
    • Q9BUP4

    Protein attributes for COQ10A Gene

    247 amino acids
    Molecular mass:
    27686 Da
    Quaternary structure:
    • Interacts with coenzyme Q.
    • Sequence=AAH26922.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAQ89220.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for COQ10A Gene


neXtProt entry for COQ10A Gene

Proteomics data for COQ10A Gene at MOPED

Post-translational modifications for COQ10A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COQ10A Gene

No data available for DME Specific Peptides for COQ10A Gene

Domains & Families for COQ10A Gene

Protein Domains for COQ10A Gene

Suggested Antigen Peptide Sequences for COQ10A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the COQ10 family.
  • Belongs to the COQ10 family.
genes like me logo Genes that share domains with COQ10A: view

No data available for Gene Families for COQ10A Gene

Function for COQ10A Gene

Molecular function for COQ10A Gene

UniProtKB/Swiss-Prot Function:
Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (Probable).

Phenotypes for COQ10A Gene

genes like me logo Genes that share phenotypes with COQ10A: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for COQ10A Gene

Localization for COQ10A Gene

Subcellular locations from UniProtKB/Swiss-Prot for COQ10A Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

Jensen Localization Image for COQ10A Gene COMPARTMENTS Subcellular localization image for COQ10A gene
Compartment Confidence
mitochondrion 3

Gene Ontology (GO) - Cellular Components for COQ10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
genes like me logo Genes that share ontologies with COQ10A: view

Pathways & Interactions for COQ10A Gene

SuperPathways for COQ10A Gene

No Data Available

Interacting Proteins for COQ10A Gene

Gene Ontology (GO) - Biological Process for COQ10A Gene


No data available for Pathways by source and SIGNOR curated interactions for COQ10A Gene

Drugs & Compounds for COQ10A Gene

No Compound Related Data Available

Transcripts for COQ10A Gene

Unigene Clusters for COQ10A Gene

Coenzyme Q10 homolog A (S. cerevisiae):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COQ10A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COQ10A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: -
SP7: - - -
SP8: -

Relevant External Links for COQ10A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COQ10A Gene

mRNA expression in normal human tissues for COQ10A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COQ10A Gene

This gene is overexpressed in Heart - Left Ventricle (x9.6), Muscle - Skeletal (x6.6), and Heart - Atrial Appendage (x4.5).

Protein differential expression in normal tissues from HIPED for COQ10A Gene

This gene is overexpressed in Heart (34.3) and Tonsil (25.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for COQ10A Gene

SOURCE GeneReport for Unigene cluster for COQ10A Gene Hs.4096

genes like me logo Genes that share expression patterns with COQ10A: view

Protein tissue co-expression partners for COQ10A Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for COQ10A Gene

Orthologs for COQ10A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COQ10A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia COQ10A 35
  • 89.81 (n)
  • 88.02 (a)
COQ10A 36
  • 88 (a)
(Canis familiaris)
Mammalia COQ10A 35
  • 89.96 (n)
  • 90.38 (a)
COQ10A 36
  • 84 (a)
(Mus musculus)
Mammalia Coq10a 35
  • 88.53 (n)
  • 90.28 (a)
Coq10a 16
Coq10a 36
  • 86 (a)
(Pan troglodytes)
Mammalia COQ10A 35
  • 99.73 (n)
  • 99.6 (a)
COQ10A 36
  • 86 (a)
(Rattus norvegicus)
Mammalia Coq10a 35
  • 91.58 (n)
  • 96.53 (a)
(Ornithorhynchus anatinus)
Mammalia COQ10A 36
  • 79 (a)
(Gallus gallus)
Aves COQ10A 35
  • 73.54 (n)
  • 81.87 (a)
(Anolis carolinensis)
Reptilia COQ10A 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3699 35
(Danio rerio)
Actinopterygii Dr.12531 35
LOC100333108 35
  • 62.45 (n)
  • 66.24 (a)
COQ10A (1 of 2) 36
  • 61 (a)
COQ10A (2 of 2) 36
  • 71 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9902 35
fruit fly
(Drosophila melanogaster)
Insecta CG9410 36
  • 34 (a)
(Caenorhabditis elegans)
Secernentea R144.13 35
  • 50.46 (n)
  • 45.89 (a)
R144.13 36
  • 42 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G17650 35
  • 48.99 (n)
  • 40.94 (a)
(Oryza sativa)
Liliopsida Os01g0772400 35
  • 50.41 (n)
  • 40.24 (a)
Species with no ortholog for COQ10A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COQ10A Gene

Gene Tree for COQ10A (if available)
Gene Tree for COQ10A (if available)

Paralogs for COQ10A Gene

Paralogs for COQ10A Gene

(1) SIMAP similar genes for COQ10A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with COQ10A: view

Variants for COQ10A Gene

Sequence variations from dbSNP and Humsavar for COQ10A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs773651 -- 56,271,104(-) AGAAT(A/G)TGCTA downstream-variant-500B
rs1045224 -- 56,270,914(+) TTATT(C/T)TTCCA utr-variant-3-prime
rs1274498 -- 56,266,909(-) CTCGG(C/T)ACCCC upstream-variant-2KB, utr-variant-5-prime
rs1274499 -- 56,266,627(-) ggaca(G/T)agtga upstream-variant-2KB
rs1274500 -- 56,265,075(-) ATAAA(A/C)GTCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for COQ10A Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV Complex 15286789

Variation tolerance for COQ10A Gene

Residual Variation Intolerance Score: 40.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.62; 56.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COQ10A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COQ10A Gene

Disorders for COQ10A Gene

Relevant External Links for COQ10A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with COQ10A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COQ10A Gene

Publications for COQ10A Gene

  1. Serum coenzyme Q10 and risk of disabling dementia: the Circulatory Risk in Communities Study (CIRCS). (PMID: 25463064) Yamagishi K. … Iso H. (Atherosclerosis 2014) 67
  2. Coenzyme Q10 deficiency in children: frequent type 2C muscle fibers with normal morphology. (PMID: 23494902) Sommerville R.B. … Pestronk A. (Muscle Nerve 2013) 67
  3. The relationship between coenzyme Q10, oxidative stress, and antioxidant enzymes activities and coronary artery disease. (PMID: 22645453) Lee B.J. … Lin P.T. (ScientificWorldJournal 2012) 67
  4. Relationship between plasma coenzyme Q10, asymmetric dimethylarginine and arterial stiffness in patients with phenotypic or genotypic familial hypercholesterolemia on long-term statin therapy. (PMID: 21640350) Young J.M. … George P.M. (Atherosclerosis 2011) 67
  5. Rosuvastatin combined with regular exercise preserves coenzyme Q10 levels associated with a significant increase in high-density lipoprotein cholesterol in patients with coronary artery disease. (PMID: 21458815) Toyama K. … Ogawa H. (Atherosclerosis 2011) 67

Products for COQ10A Gene

Sources for COQ10A Gene

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