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Aliases for COPZ2 Gene

Aliases for COPZ2 Gene

  • Coatomer Protein Complex Subunit Zeta 2 2 3 5
  • Coatomer Protein Complex, Subunit Zeta 2 2 3
  • Nonclathrin Coat Protein Zeta-COP 2 3
  • Zeta-2-Coat Protein 3 4
  • Zeta-2 COP 3 4
  • Zeta2-COP 2 3
  • Zeta-2 Coat Protein 2

External Ids for COPZ2 Gene

Previous GeneCards Identifiers for COPZ2 Gene

  • GC17M045809
  • GC17M048584
  • GC17M046445
  • GC17M046578
  • GC17M043459
  • GC17M046103
  • GC17M041472

Summaries for COPZ2 Gene

Entrez Gene Summary for COPZ2 Gene

  • This gene encodes a member of the adaptor complexes small subunit family. The encoded protein is a subunit of the coatomer protein complex, a seven-subunit complex that functions in the formation of COPI-type, non-clathrin-coated vesicles. COPI vesicles function in the retrograde Golgi-to-ER transport of dilysine-tagged proteins. [provided by RefSeq, Feb 2014]

GeneCards Summary for COPZ2 Gene

COPZ2 (Coatomer Protein Complex Subunit Zeta 2) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF). An important paralog of this gene is COPZ1.

UniProtKB/Swiss-Prot for COPZ2 Gene

  • The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPZ2 Gene

Genomics for COPZ2 Gene

Regulatory Elements for COPZ2 Gene

Enhancers for COPZ2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around COPZ2 on UCSC Golden Path with GeneCards custom track

Genomic Location for COPZ2 Gene

Chromosome:
17
Start:
48,026,167 bp from pter
End:
48,048,091 bp from pter
Size:
21,925 bases
Orientation:
Minus strand

Genomic View for COPZ2 Gene

Genes around COPZ2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COPZ2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COPZ2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPZ2 Gene

Proteins for COPZ2 Gene

  • Protein details for COPZ2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P299-COPZ2_HUMAN
    Recommended name:
    Coatomer subunit zeta-2
    Protein Accession:
    Q9P299

    Protein attributes for COPZ2 Gene

    Size:
    210 amino acids
    Molecular mass:
    23548 Da
    Quaternary structure:
    • Oligomeric complex.

neXtProt entry for COPZ2 Gene

Proteomics data for COPZ2 Gene at MOPED

Post-translational modifications for COPZ2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COPZ2 Gene

No data available for DME Specific Peptides for COPZ2 Gene

Domains & Families for COPZ2 Gene

Protein Domains for COPZ2 Gene

Suggested Antigen Peptide Sequences for COPZ2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P299

UniProtKB/Swiss-Prot:

COPZ2_HUMAN :
  • Belongs to the adaptor complexes small subunit family.
Family:
  • Belongs to the adaptor complexes small subunit family.
genes like me logo Genes that share domains with COPZ2: view

No data available for Gene Families for COPZ2 Gene

Function for COPZ2 Gene

Molecular function for COPZ2 Gene

UniProtKB/Swiss-Prot Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity).
genes like me logo Genes that share phenotypes with COPZ2: view

Animal Model Products

miRNA for COPZ2 Gene

miRTarBase miRNAs that target COPZ2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COPZ2 Gene

Localization for COPZ2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPZ2 Gene

Cytoplasm. Endoplasmic reticulum-Golgi intermediate compartment membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Shows a significant preference for ERGIC and cis-Golgi apparatus compared with trans-Golgi network. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COPZ2 Gene COMPARTMENTS Subcellular localization image for COPZ2 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for COPZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005801 cis-Golgi network NAS 11056392
GO:0005829 cytosol TAS --
GO:0030133 transport vesicle TAS --
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA --
genes like me logo Genes that share ontologies with COPZ2: view

Pathways & Interactions for COPZ2 Gene

genes like me logo Genes that share pathways with COPZ2: view

Interacting Proteins for COPZ2 Gene

Selected Interacting proteins: Q9P299-COPZ2_HUMAN for COPZ2 Gene via I2D

Gene Ontology (GO) - Biological Process for COPZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with COPZ2: view

No data available for SIGNOR curated interactions for COPZ2 Gene

Drugs & Compounds for COPZ2 Gene

No Compound Related Data Available

Transcripts for COPZ2 Gene

Unigene Clusters for COPZ2 Gene

Coatomer protein complex, subunit zeta 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COPZ2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2: -

Relevant External Links for COPZ2 Gene

GeneLoc Exon Structure for
COPZ2
ECgene alternative splicing isoforms for
COPZ2

Expression for COPZ2 Gene

mRNA expression in normal human tissues for COPZ2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for COPZ2 Gene

This gene is overexpressed in Bone marrow stromal cell (43.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for COPZ2 Gene



SOURCE GeneReport for Unigene cluster for COPZ2 Gene Hs.408434

genes like me logo Genes that share expression patterns with COPZ2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for COPZ2 Gene

Orthologs for COPZ2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for COPZ2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COPZ2 35
  • 93.02 (n)
  • 94.76 (a)
COPZ2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COPZ2 35
  • 84.95 (n)
  • 83.01 (a)
COPZ2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Copz2 35
  • 89.76 (n)
  • 91.22 (a)
Copz2 16
Copz2 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COPZ2 35
  • 96.82 (n)
  • 94.38 (a)
COPZ2 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Copz2 35
  • 89.05 (n)
  • 91.79 (a)
oppossum
(Monodelphis domestica)
Mammalia COPZ2 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COPZ2 36
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii -- 35
copz2 35
  • 71.35 (n)
  • 78.95 (a)
copz2 36
  • 68 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RET3 36
  • 31 (a)
OneToMany
Species with no ortholog for COPZ2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COPZ2 Gene

ENSEMBL:
Gene Tree for COPZ2 (if available)
TreeFam:
Gene Tree for COPZ2 (if available)

Paralogs for COPZ2 Gene

Paralogs for COPZ2 Gene

(1) SIMAP similar genes for COPZ2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with COPZ2: view

Variants for COPZ2 Gene

Sequence variations from dbSNP and Humsavar for COPZ2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs12051 -- 48,026,394(-) CCAGA(C/T)CATTT nc-transcript-variant, utr-variant-3-prime
rs757353 -- 48,044,908(+) GTTAC(A/G)GAGTA intron-variant
rs1317850 -- 48,044,477(-) TATGC(A/G)CAGCC intron-variant
rs2240119 -- 48,033,806(+) CCAGA(C/T)GGAGA intron-variant
rs3048654 -- 48,044,427(+) ttttt(-/TTT)ACCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COPZ2 Gene

Variant ID Type Subtype PubMed ID
nsv469808 CNV Complex 16826518

Variation tolerance for COPZ2 Gene

Gene Damage Index Score: 0.87; 18.13% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for COPZ2 Gene

Disorders for COPZ2 Gene

Relevant External Links for COPZ2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COPZ2

No disorders were found for COPZ2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COPZ2 Gene

Publications for COPZ2 Gene

  1. Identification and characterization of novel isoforms of COP I subunits. (PMID: 11056392) Futatsumori M. … Nakayama K. (J. Biochem. 2000) 2 3 4 67
  2. Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32. (PMID: 22949513) . … Sander T. (Hum. Mol. Genet. 2012) 3
  3. Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit IP 2 renders tumor cells dependent on its paralogous gene COPZ1. (PMID: 21746916) Shtutman M. … Roninson I.B. (Proc. Natl. Acad. Sci. U.S.A. 2011) 3
  4. Solution structure of human zeta-COP: direct evidences for structural similarity between COP I and clathrin-adaptor coats. (PMID: 19167404) Yu W. … Xia B. (J. Mol. Biol. 2009) 3
  5. Novel isotypic gamma/zeta subunits reveal three coatomer complexes in mammals. (PMID: 14729954) Wegmann D. … Reinhard C. (Mol. Cell. Biol. 2004) 3

Products for COPZ2 Gene

Sources for COPZ2 Gene

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