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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COPZ2 Gene

protein-coding   GIFtS: 48
GCID: GC17M046103

Coatomer Protein Complex, Subunit Zeta 2

  Search for COPZ2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coatomer Protein Complex, Subunit Zeta 21 2     Zeta-2 COP2 3
Nonclathrin Coat Protein Zeta-COP1 2     Zeta-2-Coat Protein2 3
Zeta-2 Coat Protein1 2     Coatomer Subunit Zeta-22
zeta2-COP1 2     

External Ids:    HGNC: 193561   Entrez Gene: 512262   Ensembl: ENSG000000052437   UniProtKB: Q9P2993   

Export aliases for COPZ2 gene to outside databases

Previous GC identifers: GC17M045809 GC17M048584 GC17M046445 GC17M046578 GC17M043459 GC17M041472


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COPZ2 Gene:
This gene encodes a subunit of the coatomer protein complex, a seven-subunit complex that functions in the
formation of COPI-type, non-clathrin-coated vesicles. COPI vesicles function in the retrograde Golgi-to-ER
transport of dilysine-tagged proteins. This gene is similar to a related family member, and the two encoded
proteins form distinct isotypes of the coatomer protein complex. (provided by RefSeq, Jul 2008)

GeneCards Summary for COPZ2 Gene: 
COPZ2 (coatomer protein complex, subunit zeta 2) is a protein-coding gene. Among its related super-pathways are Clathrin-dependent protein traffic and COPII (Coat Protein 2) Mediated Vesicle Transport. An important paralog of this gene is COPZ1.

UniProtKB/Swiss-Prot: COPZ2_HUMAN, Q9P299
Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with
Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the
Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is
essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved
in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its
association-dissociation properties with the coatomer complex (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COPZ2 gene promoter:
         Bach1   Nkx2-5   CBF-C   AREB6   HEN1   CBF-B   CBF-A   CP1A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOPZ2 promoter sequence
   Search SABiosciences Chromatin IP Primers for COPZ2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COPZ2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.2

COPZ2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COPZ2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M046103:  view genomic region     (about GC identifiers)

Start:
46,103,533 bp from pter      End:
46,115,392 bp from pter
Size:
11,860 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: COPZ2_HUMAN, Q9P299 (See protein sequence)
Recommended Name: Coatomer subunit zeta-2  
Size: 210 amino acids; 23548 Da
Subunit: Oligomeric complex
Subcellular location: Cytoplasm (By similarity). Golgi apparatus membrane; Peripheral membrane protein;
Cytoplasmic side (By similarity). Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein;
Cytoplasmic side (By similarity). Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the
Golgi, as well as on the vesicles/buds originating from it (By similarity)

Explore the universe of human proteins at neXtProt for COPZ2: NX_Q9P299

Explore proteomics data for COPZ2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P299

  • COPZ2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    COPZ2 Protein Expression
    REFSEQ proteins: NP_057513.1  
    ENSEMBL proteins: 
     ENSP00000463413   ENSP00000463687   ENSP00000462035   ENSP00000464484   ENSP00000463841  
     ENSP00000463581   ENSP00000006101  

    Human Recombinant Protein Products for COPZ2: 
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    OriGene MassSpec for COPZ2 
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    GenScript Custom Purified and Recombinant Proteins Services for COPZ2
    Novus Biologicals COPZ2 Protein
    Novus Biologicals COPZ2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005801cis-Golgi network NAS11056392
    GO:0030126COPI vesicle coat NAS11056392

    COPZ2 for ontologies           About GeneDecksing



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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR022775 AP_mu_sigma_su
     IPR011012 Longin-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9P299

    ProtoNet protein and cluster: Q9P299

    1 Blocks protein domain: IPB000804 Clathrin adaptor complex

    UniProtKB/Swiss-Prot: COPZ2_HUMAN, Q9P299
    Similarity: Belongs to the adaptor complexes small subunit family


    COPZ2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COPZ2_HUMAN, Q9P299
    Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with
    Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the
    Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is
    essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved
    in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its
    association-dissociation properties with the coatomer complex (By similarity)

    Phenotypes:
         2 GenomeRNAi human phenotypes for COPZ2:

     Decreased viability  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for COPZ2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for COPZ2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COPZ2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COPZ2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COPZ2
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate COPZ2:
    hsa-miR-4314 hsa-miR-657 hsa-miR-4277
    SwitchGear 3'UTR luciferase reporter plasmidCOPZ2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPZ2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for COPZ2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Clathrin-dependent protein traffic
    Clathrin-dependent protein traffic0.66
    wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)0.37
    Transport Clathrin-coated vesicle cycle0.66
    2COPII (Coat Protein 2) Mediated Vesicle Transport
    Delta508-CFTR traffic / ER-to-Golgi in CF0.36
    Normal wtCFTR traffic / ER-to-Golgi 0.36
    3Golgi to ER Retrograde Transport
    Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for COPZ2
        Clathrin-dependent protein traffic


    5 GeneGo (Thomson Reuters) Pathways for COPZ2
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / ER-to-Golgi in CF
    Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)
    Normal wtCFTR traffic / ER-to-Golgi
    Transport Clathrin-coated vesicle cycle



    COPZ2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COPZ2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/41 Interacting proteins for COPZ2 (Q9P2993 ENSP000000061014) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPG1Q9Y6783, ENSP000003250024I2D: score=2 STRING: ENSP00000325002
    ARCN1P484443, ENSP000002640284I2D: score=1 STRING: ENSP00000264028
    COPG2Q9UBF23, ENSP000003939124I2D: score=1 STRING: ENSP00000393912
    AP2A1ENSP000003519264STRING: ENSP00000351926
    AP2A2ENSP000004132344STRING: ENSP00000413234
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006886intracellular protein transport NAS11056392
    GO:0016192vesicle-mediated transport IEA--

    COPZ2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for COPZ2

    Search CenterWatch for drugs/clinical trials and news about COPZ2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for COPZ2 gene: 
    NM_016429.2  

    Unigene Cluster for COPZ2:

    Coatomer protein complex, subunit zeta 2
    Hs.408434  [show with all ESTs]
    Unigene Representative Sequence: NM_016429
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000580409 ENST00000583414 ENST00000581637 ENST00000581756 ENST00000585182
    ENST00000584666(uc002imy.3) ENST00000584955 ENST00000582553 ENST00000579263
    ENST00000580174 ENST00000006101
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COPZ2
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate COPZ2:
    hsa-miR-4314 hsa-miR-657 hsa-miR-4277
    SwitchGear 3'UTR luciferase reporter plasmidCOPZ2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: COPZ2 (NM_016429)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COPZ2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPZ2
    Sirion Biotech Customized lentivirus for stable overexpression of COPZ2 
                         Customized lentivirus expression plasmids for stable overexpression of COPZ2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for COPZ2
    OriGene qSTAR qPCR primer pairs in human, mouse for COPZ2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COPZ2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COPZ2

    Additional mRNA sequence: 

    AB037938.1 AB047849.1 BC015924.1 

    11 DOTS entries:

    DT.75102545  DT.99935130  DT.100023718  DT.100765061  DT.101980890  DT.40111821  DT.40118826  DT.100765062 
    DT.95261049  DT.100023719  DT.97773113 

    24/83 AceView cDNA sequences (see all 83):

    BM714206 BX112761 AA889345 AJ346796 CB243204 AI090780 AI147785 AI138947 
    BG757060 BX108178 BQ432595 AL709505 AI376738 BQ002984 BM717603 BQ576336 
    BU741263 AW237276 AI277222 BM727007 AI460194 BQ182981 AI093422 BM011090 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for COPZ2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                                                            
    SP2:                                -                           


    ECgene alternative splicing isoforms for COPZ2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COPZ2 expression in normal human tissues (normalized intensities)      COPZ2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACGGAGCCT
    COPZ2 Expression
    About this image


    COPZ2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Horizontal Cells Inner Nuclear Layer
             optic nerve head astrocytes   
     
     Hair
             Human Hair Outer Root Sheath Cells (HHORSC)   
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     Brain (Nervous System)
             optic nerve head astrocytes   
     
     Dermis (Integumentary System)
             Human Hair Outer Root Sheath Cells (HHORSC)   

    See COPZ2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COPZ2

    SOURCE GeneReport for Unigene cluster: Hs.408434
        SABiosciences Custom PCR Arrays for COPZ2
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COPZ2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPZ2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COPZ2 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Copz21 , 5 coatomer protein complex, subunit zeta 21, 5 89.76(n)1
    91.22(a)1
      11 (60.13 cM)5
    563581  NM_019877.21  NP_063930.11 
     968498705 
    lizard
    (Anolis carolinensis)
    Reptilia COPZ26
    Uncharacterized protein
    70(a)
    1 ↔ 1
    6(74901552-74922123)
    zebrafish
    (Danio rerio)
    Actinopterygii AB040045.22   -- 75.46(n)   57969  AB040045.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta zetaCOP6
    zetaCOP
    53(a)
    1 → many
    3L(16664764-16666655)
    worm
    (Caenorhabditis elegans)
    Secernentea F59E10.36
    Probable coatomer subunit zeta
    47(a)
    1 → many
    II(10872877-10873798)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RET36
    Zeta subunit of the coatomer complex (COPI), which...
    31(a)
    1 → many
    XVI(535018-535587)
    rice
    (Oryza sativa)
    Liliopsida Os01g08388001 hypothetical protein 51.42(n)
    43.29(a)
      4327378  NM_001051283.1  NP_001044748.2 


    ENSEMBL Gene Tree for COPZ2 (if available)
    TreeFam Gene Tree for COPZ2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for COPZ2 gene
    COPZ12  
    1 SIMAP similar gene for COPZ2 using alignment to 6 protein entries:     COPZ2_HUMAN (see all proteins):
    COPZ1

    COPZ2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/242 SNPs in COPZ2 are shown (see all 242)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs116568181,2
    C,F,H--47118037(+) GGAATC/ACCCAG 1 -- ds50013Minor allele frequency- A:0.16NA WA 240
    rs789156521,2
    F--47118154(+) ACCCCC/TTCATG 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1422847291,2
    C--47118285(+) TATGA-/ACACACA 1 -- ds50010--------
    rs3691004991,2
    C--47118286(+) ATATG-/ACCACAC 1 -- ds50010--------
    rs1929035111,2
    --47118287(+) ATGAAC/TACACA 1 -- ds50010--------
    rs1470012411,2
    C--47118433(+) TGAGGC/TCAAAC 1 -- ut310--------
    rs120511,2
    C,F,A,H--47118560(-) CCAGAT/CCATTT 1 -- ut3121Minor allele frequency- C:0.31MN NS EA NA WA EU 3306
    rs116577011,2
    C,H--47118677(+) ATTGAG/TAATGT 1 -- int10--------
    rs1381250401,2
    C--47118966(+) CAGGCA/GGAGAC 1 -- int10--------
    rs1435821941,2
    --47119004(+) TCAGAC/TGCCTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for COPZ2 (46103533 - 46115392 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for COPZ2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv469808CNV Complex16826518

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COPZ2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with COPZ2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of novel isoforms of COP I subunits. (PubMed id 11056392)1, 2, 3 Futatsumori M.... Nakayama K. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Genome-wide association analysis of genetic generalize d epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32 . (PubMed id 22949513)1  ....Sander T. (2012)
    4. Tumor-specific silencing of COPZ2 gene encoding coato mer protein complex subunit IP 2 renders tumor cells dependent on its paralogous gene COPZ1. (PubMed id 21746916)1 Shtutman M....Roninson I.B. (2011)
    5. Solution structure of human zeta-COP: direct evidences for structural similarity between COP I and clathrin-adaptor coats. (PubMed id 19167404)1 Yu W....Xia B. (2009)
    6. Novel isotypic gamma/zeta subunits reveal three coatomer complexes in mammals. (PubMed id 14729954)1 Wegmann D....Reinhard C. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP. (PubMed id 10921873)1 Eugster A....Duden R. (2000)
    9. RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport. (PubMed id 10982407)1 Sullivan B.M....Druey K.M. (2000)
    10. In vivo assembly of coatomer, the COP-I coat precursor. (PubMed id 8940050)1 Lowe M. and Kreis T.E. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51226 HGNC: 19356 AceView: COPZ2 Ensembl:ENSG00000005243 euGenes: HUgn51226
    ECgene: COPZ2 H-InvDB: COPZ2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COPZ2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for COPZ2 gene:
    Search GeneIP for patents involving COPZ2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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