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Aliases for COPZ2 Gene

Aliases for COPZ2 Gene

  • Coatomer Protein Complex, Subunit Zeta 2 2 3
  • Nonclathrin Coat Protein Zeta-COP 2 3
  • Zeta-2-Coat Protein 3 4
  • Zeta-2 COP 3 4
  • Zeta2-COP 2 3
  • Coatomer Subunit Zeta-2 3
  • Zeta-2 Coat Protein 2

External Ids for COPZ2 Gene

Previous GeneCards Identifiers for COPZ2 Gene

  • GC17M045809
  • GC17M048584
  • GC17M046445
  • GC17M046578
  • GC17M043459
  • GC17M046103
  • GC17M041472

Summaries for COPZ2 Gene

Entrez Gene Summary for COPZ2 Gene

  • This gene encodes a member of the adaptor complexes small subunit family. The encoded protein is a subunit of the coatomer protein complex, a seven-subunit complex that functions in the formation of COPI-type, non-clathrin-coated vesicles. COPI vesicles function in the retrograde Golgi-to-ER transport of dilysine-tagged proteins. [provided by RefSeq, Feb 2014]

GeneCards Summary for COPZ2 Gene

COPZ2 (Coatomer Protein Complex, Subunit Zeta 2) is a Protein Coding gene. Among its related pathways are COPI Mediated Transport and Delta508-CFTR traffic / ER-to-Golgi in CF. An important paralog of this gene is COPZ1.

UniProtKB/Swiss-Prot for COPZ2 Gene

  • The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPZ2 Gene

Genomics for COPZ2 Gene

Regulatory Elements for COPZ2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COPZ2 Gene

Start:
48,026,167 bp from pter
End:
48,038,030 bp from pter
Size:
11,864 bases
Orientation:
Minus strand

Genomic View for COPZ2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COPZ2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPZ2 Gene

Proteins for COPZ2 Gene

  • Protein details for COPZ2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P299-COPZ2_HUMAN
    Recommended name:
    Coatomer subunit zeta-2
    Protein Accession:
    Q9P299
    Secondary Accessions:

    Protein attributes for COPZ2 Gene

    Size:
    210 amino acids
    Molecular mass:
    23548 Da
    Quaternary structure:
    • Oligomeric complex

neXtProt entry for COPZ2 Gene

Proteomics data for COPZ2 Gene at MOPED

Post-translational modifications for COPZ2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COPZ2 Gene

No data available for DME Specific Peptides for COPZ2 Gene

Domains for COPZ2 Gene

Protein Domains for COPZ2 Gene

Suggested Antigen Peptide Sequences for COPZ2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P299

UniProtKB/Swiss-Prot:

COPZ2_HUMAN :
  • Q9P299
Family:
  • Belongs to the adaptor complexes small subunit family.
genes like me logo Genes that share domains with COPZ2: view

No data available for Gene Families for COPZ2 Gene

Function for COPZ2 Gene

Molecular function for COPZ2 Gene

UniProtKB/Swiss-Prot Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity).

Phenotypes for COPZ2 Gene

GenomeRNAi human phenotypes for COPZ2:
genes like me logo Genes that share phenotypes with COPZ2: view

Animal Model Products

CRISPR Products

miRNA for COPZ2 Gene

miRTarBase miRNAs that target COPZ2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COPZ2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for COPZ2 Gene

Localization for COPZ2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPZ2 Gene

Cytoplasm. Endoplasmic reticulum-Golgi intermediate compartment membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Shows a significant preference for ERGIC and cis-Golgi apparatus compared with trans-Golgi network. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COPZ2 Gene COMPARTMENTS Subcellular localization image for COPZ2 gene
Compartment Confidence
golgi apparatus 5
cytosol 3
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for COPZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005801 cis-Golgi network NAS 11056392
GO:0030126 COPI vesicle coat NAS 11056392
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA --
genes like me logo Genes that share ontologies with COPZ2: view

Pathways for COPZ2 Gene

genes like me logo Genes that share pathways with COPZ2: view

Interacting Proteins for COPZ2 Gene

Selected Interacting proteins: Q9P299-COPZ2_HUMAN for COPZ2 Gene via I2D

Gene Ontology (GO) - Biological Process for COPZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006886 intracellular protein transport NAS 11056392
GO:0015031 protein transport --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with COPZ2: view

Transcripts for COPZ2 Gene

mRNA/cDNA for COPZ2 Gene

Unigene Clusters for COPZ2 Gene

Coatomer protein complex, subunit zeta 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COPZ2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COPZ2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2: -

Relevant External Links for COPZ2 Gene

GeneLoc Exon Structure for
COPZ2
ECgene alternative splicing isoforms for
COPZ2

Expression for COPZ2 Gene

mRNA expression in normal human tissues for COPZ2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for COPZ2 Gene

SOURCE GeneReport for Unigene cluster for COPZ2 Gene Hs.408434

genes like me logo Genes that share expressions with COPZ2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COPZ2 Gene

Orthologs for COPZ2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for COPZ2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COPZ2 35
  • 96.82 (n)
  • 94.38 (a)
COPZ2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COPZ2 35
  • 93.02 (n)
  • 94.76 (a)
COPZ2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COPZ2 35
  • 84.95 (n)
  • 83.01 (a)
COPZ2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Copz2 35
  • 89.76 (n)
  • 91.22 (a)
Copz2 16
Copz2 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COPZ2 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Copz2 35
  • 89.05 (n)
  • 91.79 (a)
lizard
(Anolis carolinensis)
Reptilia COPZ2 36
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii -- 35
copz2 35
  • 71.35 (n)
  • 78.95 (a)
copz2 36
  • 68 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RET3 36
  • 31 (a)
OneToMany
Species with no ortholog for COPZ2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COPZ2 Gene

ENSEMBL:
Gene Tree for COPZ2 (if available)
TreeFam:
Gene Tree for COPZ2 (if available)

Paralogs for COPZ2 Gene

Paralogs for COPZ2 Gene

Selected SIMAP similar genes for COPZ2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with COPZ2: view

Variants for COPZ2 Gene

Sequence variations from dbSNP and Humsavar for COPZ2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs12051 -- 48,026,394(-) CCAGA(C/T)CATTT utr-variant-3-prime
rs2240119 -- 48,033,806(+) CCAGA(C/T)GGAGA intron-variant
rs3169821 -- 48,026,220(-) CATAT(C/T)TTAGG utr-variant-3-prime
rs7209072 -- 48,033,103(+) AAAAG(A/G)AGGGG intron-variant
rs7210041 -- 48,036,456(+) TTAGA(C/T)TAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COPZ2 Gene

Variant ID Type Subtype PubMed ID
nsv469808 CNV Complex 16826518

Relevant External Links for COPZ2 Gene

HapMap Linkage Disequilibrium report
COPZ2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COPZ2 Gene

Disorders for COPZ2 Gene

No disorders were found for COPZ2 Gene.

No data available for UniProtKB/Swiss-Prot for COPZ2 Gene

Publications for COPZ2 Gene

  1. Identification and characterization of novel isoforms of COP I subunits. (PMID: 11056392) Futatsumori M. … Nakayama K. (J. Biochem. 2000) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Solution structure of human zeta-COP: direct evidences for structural similarity between COP I and clathrin-adaptor coats. (PMID: 19167404) Yu W. … Xia B. (J. Mol. Biol. 2009) 3
  4. Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit IP 2 renders tumor cells dependent on its paralogous gene COPZ1. (PMID: 21746916) Shtutman M. … Roninson I.B. (Proc. Natl. Acad. Sci. U.S.A. 2011) 3
  5. Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32. (PMID: 22949513) . … Sander T. (Hum. Mol. Genet. 2012) 3

Products for COPZ2 Gene

Sources for COPZ2 Gene

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