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COPZ2 Gene

protein-coding   GIFtS: 50
GCID: GC17M046103

Coatomer Protein Complex, Subunit Zeta 2

  Search for COPZ2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Coatomer Protein Complex, Subunit Zeta 21 2     Zeta-2-Coat Protein2 3
Nonclathrin Coat Protein Zeta-COP1 2     Zeta-2 Coat Protein1
zeta2-COP1 2     Coatomer Subunit Zeta-22
Zeta-2 COP2 3     

External Ids:    HGNC: 193561   Entrez Gene: 512262   Ensembl: ENSG000000052437   OMIM: 6155265   UniProtKB: Q9P2993   
ORGUL members:         

Export aliases for COPZ2 gene to outside databases

Previous GC identifers: GC17M045809 GC17M048584 GC17M046445 GC17M046578 GC17M043459 GC17M041472


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COPZ2 Gene:
This gene encodes a member of the adaptor complexes small subunit family. The encoded protein is a subunit of the
coatomer protein complex, a seven-subunit complex that functions in the formation of COPI-type,
non-clathrin-coated vesicles. COPI vesicles function in the retrograde Golgi-to-ER transport of dilysine-tagged
proteins. (provided by RefSeq, Feb 2014)

GeneCards Summary for COPZ2 Gene:
COPZ2 (coatomer protein complex, subunit zeta 2) is a protein-coding gene. An important paralog of this gene is COPZ1.

UniProtKB/Swiss-Prot: COPZ2_HUMAN, Q9P299
Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with
Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the
Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is
essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved
in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its
association-dissociation properties with the coatomer complex (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the COPZ2 gene promoter:
         Bach1   Nkx2-5   CBF-C   AREB6   HEN1   CBF-B   CBF-A   CP1A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOPZ2 promoter sequence
   Search Chromatin IP Primers for COPZ2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COPZ2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.2

COPZ2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COPZ2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M046103:  view genomic region     (about GC identifiers)

Start:
46,103,533 bp from pter      End:
46,115,392 bp from pter
Size:
11,860 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: COPZ2_HUMAN, Q9P299 (See protein sequence)
Recommended Name: Coatomer subunit zeta-2  
Size: 210 amino acids; 23548 Da
Subunit: Oligomeric complex

Explore the universe of human proteins at neXtProt for COPZ2: NX_Q9P299

Explore proteomics data for COPZ2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See COPZ2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057513.1  
    ENSEMBL proteins: 
     ENSP00000463413   ENSP00000463687   ENSP00000462035   ENSP00000464484   ENSP00000463841  
     ENSP00000463581   ENSP00000006101  

    COPZ2 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

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    COPZ2 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR022775 AP_mu_sigma_su
     IPR011012 Longin-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9P299

    ProtoNet protein and cluster: Q9P299

    1 Blocks protein domain: IPB000804 Clathrin adaptor complex

    UniProtKB/Swiss-Prot: COPZ2_HUMAN, Q9P299
    Similarity: Belongs to the adaptor complexes small subunit family


    COPZ2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COPZ2_HUMAN, Q9P299
    Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with
    Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the
    Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is
    essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved
    in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its
    association-dissociation properties with the coatomer complex (By similarity)

    Phenotypes:
         2 GenomeRNAi human phenotypes for COPZ2:

     Decreased viability  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COPZ2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COPZ2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COPZ2

    miRNA
    Products:
        
    miRTarBase miRNAs that target COPZ2:
    hsa-mir-26b-5p (MIRT029575)

    Block miRNA regulation of human, mouse, rat COPZ2 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate COPZ2:
    hsa-miR-4314 hsa-miR-657 hsa-miR-4277
    SwitchGear 3'UTR luciferase reporter plasmidCOPZ2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for COPZ2
    Predesigned siRNA for gene silencing in human, mouse, rat COPZ2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for COPZ2

    Clone
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    OriGene clones in human, mouse for COPZ2 (see all 8)
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    GenScript: all cDNA clones in your preferred vector: COPZ2 (NM_016429)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPZ2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPZ2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COPZ2_HUMAN, Q9P299: Cytoplasm (By similarity). Endoplasmic reticulum-Golgi intermediate compartment membrane;
    Peripheral membrane protein; Cytoplasmic side (By similarity). Golgi apparatus membrane; Peripheral membrane
    protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane
    protein; Cytoplasmic side (By similarity). Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic
    side of the Golgi, as well as on the vesicles/buds originating from it (By similarity). Shows a significant
    preference for ERGIC and cis-Golgi apparatus compared with trans-Golgi network (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol3
    nucleus2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005801cis-Golgi network NAS11056392
    GO:0016020membrane ----
    GO:0030126COPI vesicle coat NAS11056392
    GO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane IEA--

    COPZ2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for COPZ2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Clathrin dependent protein traffic
    Clathrin dependent protein traffic0.66
    wtCFTR and delta508 CFTR traffic Generic schema norm and CF 0.37
    Transport Clathrin coated vesicle cycle0.66
    2ER to Golgi Transport
    Delta508 CFTR traffic ER to Golgi in CF0.36
    Normal wtCFTR traffic ER to Golgi 0.36
    3COPI Mediated Transport
    Cholesterol and Sphingolipids transport Transport from Golgi and ER to the apical membrane normal and CF 0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 GeneGo (Thomson Reuters) Pathways for COPZ2
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / ER-to-Golgi in CF
    Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)
    Normal wtCFTR traffic / ER-to-Golgi
    Transport Clathrin-coated vesicle cycle


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for COPZ2
    Interactions:

        Search GeneGlobe Interaction Network for COPZ2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COPZ2 (Q9P2993 ENSP000000061014) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPG1Q9Y6783, ENSP000003250024I2D: score=2 STRING: ENSP00000325002
    ARCN1P484443, ENSP000002640284I2D: score=1 STRING: ENSP00000264028
    COPG2Q9UBF23, ENSP000003939124I2D: score=1 STRING: ENSP00000393912
    AP2A1ENSP000003519264STRING: ENSP00000351926
    AP2A2ENSP000004132344STRING: ENSP00000413234
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0006886intracellular protein transport NAS11056392
    GO:0015031protein transport ----
    GO:0016192vesicle-mediated transport IEA--

    COPZ2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COPZ2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for COPZ2 gene: 
    NM_016429.3  

    Unigene Cluster for COPZ2:

    Coatomer protein complex, subunit zeta 2
    Hs.408434  [show with all ESTs]
    Unigene Representative Sequence: NM_016429
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000580409 ENST00000583414 ENST00000581637 ENST00000581756 ENST00000585182
    ENST00000584666(uc002imy.3) ENST00000584955 ENST00000582553 ENST00000579263
    ENST00000580174 ENST00000006101
    miRNA
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    Block miRNA regulation of human, mouse, rat COPZ2 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate COPZ2:
    hsa-miR-4314 hsa-miR-657 hsa-miR-4277
    SwitchGear 3'UTR luciferase reporter plasmidCOPZ2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for COPZ2
    Predesigned siRNA for gene silencing in human, mouse, rat COPZ2
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    GenScript: all cDNA clones in your preferred vector: COPZ2 (NM_016429)
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    Primer
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    OriGene qPCR primer pairs and template standards for COPZ2
    OriGene qSTAR qPCR primer pairs in human, mouse for COPZ2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COPZ2
      QuantiTect SYBR Green Assays in human, mouse, rat COPZ2
      QuantiFast Probe-based Assays in human, mouse, rat COPZ2

    Additional mRNA sequence: 

    AB037938.1 AB047849.1 BC015924.1 

    11 DOTS entries:

    DT.75102545  DT.99935130  DT.100023718  DT.100765061  DT.101980890  DT.40111821  DT.40118826  DT.100765062 
    DT.95261049  DT.100023719  DT.97773113 

    Selected AceView cDNA sequences (see all 83):

    AJ346796 BX112761 AI090780 AA889345 AI147785 AI138947 BM714206 CB243204 
    BX108178 CF130270 CF130395 AB037938 AW237276 AK056419 BQ432595 BU741263 
    W65404 CA415465 AA343010 CA426004 BI828129 CA414491 AW269830 BQ002984 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for COPZ2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                                                            
    SP2:                                -                           


    ECgene alternative splicing isoforms for COPZ2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COPZ2 expression in normal human tissues (normalized intensities)      COPZ2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACGGAGCCT
    COPZ2 Expression
    About this image


    COPZ2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             Mature Horizontal Cells Inner Nuclear Layer
     
     Adipose (Muscoskeletal System)
    COPZ2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COPZ2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.408434
        Custom PCR Arrays for COPZ2
    Primer
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    OriGene qPCR primer pairs and template standards for COPZ2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPZ2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for COPZ2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Copz21 , 5 coatomer protein complex, subunit zeta 21, 5 89.76(n)1
    91.22(a)1
      11 (60.13 cM)5
    563581  NM_019877.21  NP_063930.11 
     968498705 
    lizard
    (Anolis carolinensis)
    Reptilia COPZ26
    coatomer protein complex, subunit zeta 2
    71(a)
    1 ↔ 1
    6(74901552-74922123)
    zebrafish
    (Danio rerio)
    Actinopterygii AB040045.22   -- 75.46(n)   57969  AB040045.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RET36
    Zeta subunit of the coatomer complex (COPI), which...
    31(a)
    1 → many
    XVI(535018-535587) YPL010W


    ENSEMBL Gene Tree for COPZ2 (if available)
    TreeFam Gene Tree for COPZ2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for COPZ2 gene
    COPZ12  
    1 SIMAP similar gene for COPZ2 using alignment to 6 protein entries:     COPZ2_HUMAN (see all proteins):
    COPZ1

    COPZ2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COPZ2 (see all 242)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs116568181,2
    C,F,H--47118037(+) GGAATC/ACCCAG 1 -- ds50013Minor allele frequency- A:0.16NA WA 240
    rs789156521,2
    F--47118154(+) ACCCCC/TTCATG 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1422847291,2
    C--47118285(+) TATGA-/ACACACA 1 -- ds50010--------
    rs3691004991,2
    C--47118286(+) ATATG-/ACCACAC 1 -- ds50010--------
    rs1929035111,2
    --47118287(+) ATGAAC/TACACA 1 -- ds50010--------
    rs1470012411,2
    C--47118433(+) TGAGGC/TCAAAC 1 -- ut310--------
    rs120511,2
    C,F,A,H--47118560(-) CCAGAT/CCATTT 1 -- ut3121Minor allele frequency- C:0.31MN NS EA NA WA EU 3306
    rs116577011,2
    C,H--47118677(+) ATTGAG/TAATGT 1 -- int10--------
    rs1381250401,2
    C--47118966(+) CAGGCA/GGAGAC 1 -- int10--------
    rs1435821941,2
    --47119004(+) TCAGAC/TGCCTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for COPZ2 (46103533 - 46115392 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for COPZ2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv469808CNV Complex16826518

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COPZ2
    DNA2.0 Custom Variant and Variant Library Synthesis for COPZ2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615526    OMIM disorders: --


    COPZ2 for disorders           About GeneDecksing


    Export disorders for COPZ2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COPZ2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with COPZ2)
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    1. Identification and characterization of novel isoforms of COP I subunits. (PubMed id 11056392)1, 2, 3 Futatsumori M.... Nakayama K. (J. Biochem. 2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32. (PubMed id 22949513)1  ....Sander T. (Hum. Mol. Genet. 2012)
    4. Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit IP 2 renders tumor cells dependent on its paralogous gene COPZ1. (PubMed id 21746916)1 Shtutman M....Roninson I.B. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    5. Solution structure of human zeta-COP: direct evidences for structural similarity between COP I and clathrin-adaptor coats. (PubMed id 19167404)1 Yu W.... Xia B. (J. Mol. Biol. 2009)
    6. Novel isotypic gamma/zeta subunits reveal three coatomer complexes in mammals. (PubMed id 14729954)1 Wegmann D....Reinhard C. (Mol. Cell. Biol. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP. (PubMed id 10921873)1 Eugster A....Duden R. (EMBO J. 2000)
    9. RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport. (PubMed id 10982407)1 Sullivan B.M....Druey K.M. (Mol. Biol. Cell 2000)
    10. In vivo assembly of coatomer, the COP-I coat precursor. (PubMed id 8940050)1 Lowe M. and Kreis T.E. (J. Biol. Chem. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51226 HGNC: 19356 AceView: COPZ2 Ensembl:ENSG00000005243 euGenes: HUgn51226
    ECgene: COPZ2 H-InvDB: COPZ2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for COPZ2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for COPZ2 gene:
    Search GeneIP for patents involving COPZ2

    GeneCards and IP:
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