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Aliases for COPZ1 Gene

Aliases for COPZ1 Gene

  • Coatomer Protein Complex Subunit Zeta 1 2 3 5
  • Coatomer Protein Complex, Subunit Zeta 1 2 3
  • Zeta-1-Coat Protein 3 4
  • Zeta-1 COP 3 4
  • COPZ 3 4
  • Coatomer Protein Complex, Subunit Zeta 2
  • Zeta1-COP 3
  • Zeta-COP 3
  • CGI-120 3
  • HSPC181 3

External Ids for COPZ1 Gene

Previous HGNC Symbols for COPZ1 Gene

  • COPZ

Previous GeneCards Identifiers for COPZ1 Gene

  • GC12P054846
  • GC12U900056
  • GC12P053005
  • GC12P054718
  • GC12P051758

Summaries for COPZ1 Gene

Entrez Gene Summary for COPZ1 Gene

  • This gene encodes a subunit of the cytoplasmic coatamer protein complex, which is involved in autophagy and intracellular protein trafficking. The coatomer protein complex is comprised of seven subunits and functions as the coat protein of coat protein complex (COP)I-vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for COPZ1 Gene

COPZ1 (Coatomer Protein Complex Subunit Zeta 1) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Golgi-to-ER retrograde transport. An important paralog of this gene is COPZ2.

UniProtKB/Swiss-Prot for COPZ1 Gene

  • The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).

  • The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

Gene Wiki entry for COPZ1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPZ1 Gene

Genomics for COPZ1 Gene

Regulatory Elements for COPZ1 Gene

Enhancers for COPZ1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around COPZ1 on UCSC Golden Path with GeneCards custom track

Promoters for COPZ1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COPZ1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the COPZ1 gene promoter:

Genomic Location for COPZ1 Gene

Chromosome:
12
Start:
54,301,202 bp from pter
End:
54,351,851 bp from pter
Size:
50,650 bases
Orientation:
Plus strand

Genomic View for COPZ1 Gene

Genes around COPZ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COPZ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COPZ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPZ1 Gene

Proteins for COPZ1 Gene

  • Protein details for COPZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61923-COPZ1_HUMAN
    Recommended name:
    Coatomer subunit zeta-1
    Protein Accession:
    P61923
    Secondary Accessions:
    • B4DDX8
    • B4DHZ0
    • F8VS17
    • F8VWL5
    • Q549N6
    • Q9Y3C3

    Protein attributes for COPZ1 Gene

    Size:
    177 amino acids
    Molecular mass:
    20198 Da
    Quaternary structure:
    • Oligomeric complex that consists of at least the alpha, beta, beta, gamma, delta, epsilon and zeta subunits.

    Three dimensional structures from OCA and Proteopedia for COPZ1 Gene

    Alternative splice isoforms for COPZ1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COPZ1 Gene

Proteomics data for COPZ1 Gene at MOPED

Post-translational modifications for COPZ1 Gene

  • Ubiquitination at Lys 29, Lys 39, Lys 46, Lys 51, Lys 168, and Lys 172
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for COPZ1 Gene

Domains & Families for COPZ1 Gene

Protein Domains for COPZ1 Gene

Graphical View of Domain Structure for InterPro Entry

P61923

UniProtKB/Swiss-Prot:

COPZ1_HUMAN :
  • Belongs to the adaptor complexes small subunit family.
Family:
  • Belongs to the adaptor complexes small subunit family.
genes like me logo Genes that share domains with COPZ1: view

No data available for Gene Families for COPZ1 Gene

Function for COPZ1 Gene

Molecular function for COPZ1 Gene

UniProtKB/Swiss-Prot Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
UniProtKB/Swiss-Prot Function:
The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.
genes like me logo Genes that share phenotypes with COPZ1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COPZ1 Gene

Localization for COPZ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPZ1 Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COPZ1 Gene COMPARTMENTS Subcellular localization image for COPZ1 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
cytoskeleton 3
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for COPZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030133 transport vesicle TAS --
genes like me logo Genes that share ontologies with COPZ1: view

Pathways & Interactions for COPZ1 Gene

genes like me logo Genes that share pathways with COPZ1: view

Gene Ontology (GO) - Biological Process for COPZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS 11030615
GO:0015031 protein transport IEA --
GO:0048205 COPI coating of Golgi vesicle TAS --
genes like me logo Genes that share ontologies with COPZ1: view

No data available for SIGNOR curated interactions for COPZ1 Gene

Drugs & Compounds for COPZ1 Gene

(1) Drugs for COPZ1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with COPZ1: view

Transcripts for COPZ1 Gene

Unigene Clusters for COPZ1 Gene

Coatomer protein complex, subunit zeta 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COPZ1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - -
SP7: -
SP8: -

Relevant External Links for COPZ1 Gene

GeneLoc Exon Structure for
COPZ1
ECgene alternative splicing isoforms for
COPZ1

Expression for COPZ1 Gene

mRNA expression in normal human tissues for COPZ1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COPZ1 Gene



SOURCE GeneReport for Unigene cluster for COPZ1 Gene Hs.505652

genes like me logo Genes that share expression patterns with COPZ1: view

Protein tissue co-expression partners for COPZ1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COPZ1 Gene

Orthologs for COPZ1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COPZ1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COPZ1 35
  • 96.88 (n)
  • 99.42 (a)
COPZ1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Copz1 35
  • 92.98 (n)
  • 100 (a)
Copz1 16
Copz1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COPZ1 35
  • 99.81 (n)
  • 100 (a)
COPZ1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Copz1 35
  • 92.01 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia COPZ1 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COPZ1 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75577 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.22784 35
zebrafish
(Danio rerio)
Actinopterygii copz1 35
  • 80.31 (n)
  • 94.15 (a)
copz1 36
  • 83 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9606 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006522 35
  • 66.28 (n)
  • 63.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta zetaCOP 35
  • 64.44 (n)
  • 63.03 (a)
zetaCOP 36
  • 60 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F59E10.3 35
  • 59.02 (n)
  • 56.47 (a)
copz-1 36
  • 53 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL016C 35
  • 51.93 (n)
  • 39.86 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F27313g 35
  • 48.43 (n)
  • 42.77 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RET3 35
  • 50.68 (n)
  • 42.47 (a)
RET3 36
  • 34 (a)
OneToMany
RET3 38
rice
(Oryza sativa)
Liliopsida Os05g0461000 35
  • 54.76 (n)
  • 43.45 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3964 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02538 35
  • 51.31 (n)
  • 43.03 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ret3 35
  • 52.04 (n)
  • 43.88 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5770 36
  • 68 (a)
OneToOne
Species with no ortholog for COPZ1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COPZ1 Gene

ENSEMBL:
Gene Tree for COPZ1 (if available)
TreeFam:
Gene Tree for COPZ1 (if available)

Paralogs for COPZ1 Gene

Paralogs for COPZ1 Gene

genes like me logo Genes that share paralogs with COPZ1: view

Variants for COPZ1 Gene

Sequence variations from dbSNP and Humsavar for COPZ1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs7297265 -- 54,325,905(+) tctcc(A/G)cctcc intron-variant
rs12813620 -- 54,323,692(+) tcctt(C/T)ctttc upstream-variant-2KB
rs12815234 -- 54,326,962(+) TATTC(C/T)TTTTT intron-variant
rs12815255 -- 54,326,997(+) ttttt(C/T)tgaga intron-variant
rs2141587 -- 54,343,917(-) AGGTT(C/T)AAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COPZ1 Gene

Variant ID Type Subtype PubMed ID
nsv520202 CNV Loss 19592680

Variation tolerance for COPZ1 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COPZ1 Gene

HapMap Linkage Disequilibrium report
COPZ1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COPZ1 Gene

Disorders for COPZ1 Gene

Relevant External Links for COPZ1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COPZ1

No disorders were found for COPZ1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COPZ1 Gene

Publications for COPZ1 Gene

  1. Solution structure of human zeta-COP: direct evidences for structural similarity between COP I and clathrin-adaptor coats. (PMID: 19167404) Yu W. … Xia B. (J. Mol. Biol. 2009) 3 4 67
  2. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for COPZ1 Gene

Sources for COPZ1 Gene

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