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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

COPZ1 Gene

protein-coding GIFtS: 55
GCID: GC12P054718

coatomer protein complex, subunit zeta 1

(Previous names: coatomer protein complex, subunit zeta )
(Previous symbol: COPZ)

Explore 3 diseases affiliated with
COPZ1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Coatomer Protein Complex, Subunit Zeta 1¹ ²		Coatomer Protein Complex, Subunit Zeta¹
COPZ¹ ² ³		HSPC181²
Zeta-1 COP² ³		Coatomer Subunit Zeta-1²
Zeta-1-Coat Protein² ³		Zeta-COP¹
CGI-120¹		Zeta1-COP¹

External Ids:	HGNC: 2243¹	Entrez Gene: 22818²	Ensembl: ENSG00000111481⁷	UniProtKB: P61923³

Export aliases for COPZ1 gene to outside databases

Previous GC identifers: GC12P054846 GC12U900056 GC12P053005 GC12P051758

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COPZ1:

This gene encodes a subunit of the cytoplasmic coatamer protein complex, which is involved in autophagy and

intracellular protein trafficking. The coatomer protein complex is comprised of seven subunits and functions as the

coat protein of coat protein complex (COP)I-vesicles. Alternative splicing results in multiple transcript variants.

(provided by RefSeq, Nov 2012)

UniProtKB/Swiss-Prot: COPZ1_HUMAN, P61923

Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with

Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up

to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the

retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by

membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also

influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL

receptors (By similarity)

Function: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein

transport due to its association-dissociation properties with the coatomer complex

Gene Wiki entry for COPZ1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the COPZ1 gene promoter:
TBP AML1a TFIID
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: COPZ1 promoter sequence

Search SABiosciences Chromatin IP Primers for COPZ1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COPZ1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2-q13.3 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13.2-q13.3

COPZ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COPZ1 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P054718: view genomic region (about GC identifiers)

Start:	54,694,986 bp from pter	End:	54,745,633 bp from pter
Size:	50,648 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: COPZ1_HUMAN, P61923 (See protein sequence)

Recommended Name: Coatomer subunit zeta-1

Size: 177 amino acids; 20198 Da

Subunit: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits

Subcellular location: Cytoplasm (By similarity). Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic

side (By similarity). Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side

(By similarity). Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on

the vesicles/buds originating from it (By similarity)

1 PDB 3D structure from and Proteopedia for COPZ1:

2HF6 (3D)

Secondary accessions: Q549N6 Q9Y3C3

Explore the universe of human proteins at neXtProt for COPZ1: NX_P61923

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P61923

COPZ1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001258663.1 NP_001258664.1 NP_001258665.1 NP_057141.1

ENSEMBL proteins:

ENSP00000449414 ENSP00000262061 ENSP00000449270 ENSP00000447100 ENSP00000449341

ENSP00000448997 ENSP00000448444 ENSP00000410620 ENSP00000448005 ENSP00000448235

ENSP00000449108 ENSP00000448945 ENSP00000449072 ENSP00000388141

Reactome Protein details: P61923
Human Recombinant Protein Products:

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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: COPZ1 OriGene Protein Over-expression Lysate: COPZ1 OriGene Custom Protein Services for COPZ1
	GenScript Custom Purified and Recombinant Proteins Services for COPZ1
	Novus Biologicals COPZ1 Proteins Novus Biologicals COPZ1 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for COPZ1
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0030117	membrane coat	--	--
GO:0030126	COPI vesicle coat	ISS	--

COPZ1 for ontologies About GeneDecksing

COPZ1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Novus Biologicals COPZ1 Antibodies
	Search for Antibodies for COPZ1 at Abcam
	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for COPZ1

Assay Products for COPZ1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for COPZ1
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

COPZ1 for domains About GeneDecksing

3 InterPro domains/families:

IPR000804 Clathrin_sm-chain_CS

IPR022775 AP_mu_sigma_su

IPR011012 Longin-like_dom

Graphical View of Domain Structure for InterPro Entry P61923

ProtoNet protein and cluster: P61923

1 Blocks protein family: IPB000804 Clathrin adaptor complex

UniProtKB/Swiss-Prot: COPZ1_HUMAN, P61923

Similarity: Belongs to the adaptor complexes small subunit family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: COPZ1_HUMAN, P61923

Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with

Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up

to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the

retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by

membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also

influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL

receptors (By similarity)

Function: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein

transport due to its association-dissociation properties with the coatomer complex

miRNA Products:		OriGene 3'-UTR Clone: COPZ1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COPZ1
		8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate COPZ1 (see all 21):
		hsa-miR-148b* hsa-miR-125a-5p hsa-miR-449a hsa-miR-125b hsa-miR-3148 hsa-miR-2113 hsa-miR-4324 hsa-miR-34c-5p

		SwitchGear 3'UTR luciferase reporter plasmid: COPZ1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COPZ1 (see all 7) OriGene shRNA RFP: COPZ1 OriGene siRNA: COPZ1
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for COPZ1

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		GenScript: all cDNA clones in your preferred vector: COPZ1 (NM_016057)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for COPZ1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPZ1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for COPZ1
		Search LifeMap BioReagents cell lines for COPZ1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPZ1

9 GenomeRNAi human phenotypes for COPZ1:

Decreased Hepatitis C virus re	Decreased Wnt reporter activit	Decreased influenza A virus in	Decreased viability
Decreased viability of wild-ty	G0/1 arrest	Increased G1 DNA content	Increased gamma-H2AX phosphory
Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Coatomer:Arf1-GTP:GAP lattice formation on golgi membrane

Coatomer:Arf1-GTP:GAP lattice formation on golgi membrane	1.00	COPI Mediated Transport	0.90
Hydrolysis of Arf1-GTP to Arf1-GDP	1.00	Golgi vesicle lattice disassociation	0.89
Diffusion of inactive Arf1-GDP from membrane	1.00	Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)	0.32
Golgi to ER Retrograde Transport	0.90

Clathrin-dependent protein traffic

	Clathrin-dependent protein traffic	1.00			wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)	0.37
	Transport_Clathrin-coated vesicle cycle	0.66

COPII (Coat Protein 2) Mediated Vesicle Transport

Normal wtCFTR traffic / ER-to-Golgi

0.36

Delta508-CFTR traffic / ER-to-Golgi in CF

0.36

Membrane Trafficking

Membrane Trafficking

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for COPZ1

Clathrin-dependent protein traffic

5 GeneGo (Thomson Reuters) Pathways for COPZ1

	wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
	Delta508-CFTR traffic / ER-to-Golgi in CF
	Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)
	Normal wtCFTR traffic / ER-to-Golgi
	Transport Clathrin-coated vesicle cycle

5/7 Reactome Pathways for COPZ1 (see all 7)

	Hydrolysis of Arf1-GTP to Arf1-GDP
	Diffusion of inactive Arf1-GDP from membrane
	Membrane Trafficking
	COPI Mediated Transport
	Golgi to ER Retrograde Transport

COPZ1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for COPZ1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/52 Interacting proteins for COPZ1 (P61923³ ENSP00000262061⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 52)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COPG2	Q9UBF2³, ENSP00000393912⁴	I2D: score=7 STRING: ENSP00000393912
ARCN1	P48444³, ENSP00000264028⁴	I2D: score=6 STRING: ENSP00000264028
COPG1	Q9Y678³, ENSP00000325002⁴	I2D: score=3 STRING: ENSP00000325002
COPB1	P53618³, ENSP00000249923⁴	I2D: score=6 STRING: ENSP00000249923
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	--	--
GO:0006886	intracellular protein transport	IEA	--
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	TAS	--
GO:0006891	intra-Golgi vesicle-mediated transport	ISS	--
GO:0016044	cellular membrane organization	TAS	--

COPZ1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for COPZ1

1 HMDB Compound for COPZ1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about COPZ1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for COPZ1 gene (4 alternative transcripts):

NM_001271734.1 NM_001271735.1 NM_001271736.1 NM_016057.2

Unigene Cluster for COPZ1:

Coatomer protein complex, subunit zeta 1

Hs.505652 [show with all ESTs]

Unigene Representative Sequence: NM_001271736

18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):

ENST00000552848 ENST00000548076 ENST00000553009 ENST00000262061(uc001sfs.1 uc001sft.2 uc009znm.1 uc010sot.1)

ENST00000549043 ENST00000551962 ENST00000552218 ENST00000551412 ENST00000550027

ENST00000553231 ENST00000552362 ENST00000455864 ENST00000550171 ENST00000549116

ENST00000551779 ENST00000548281 ENST00000548753 ENST00000550713

miRNA Products:		OriGene 3'-UTR Clone: COPZ1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COPZ1
		8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate COPZ1 (see all 21):
		hsa-miR-148b* hsa-miR-125a-5p hsa-miR-449a hsa-miR-125b hsa-miR-3148 hsa-miR-2113 hsa-miR-4324 hsa-miR-34c-5p

		SwitchGear 3'UTR luciferase reporter plasmid: COPZ1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COPZ1 (see all 7) OriGene shRNA RFP: COPZ1 OriGene siRNA: COPZ1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COPZ1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COPZ1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COPZ1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: COPZ1 (NM_016057)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for COPZ1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPZ1

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COPZ1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COPZ1

Additional cDNA sequence:

AB047848.1 AF086911.1 AF151878.1 AF161529.1 AK025956.1 AK026190.1 AK223188.1 AK293377.1

AK295325.1 AK311027.1 BC002849.2 NR_073424.1

24/26 DOTS entries (see all 26):

DT.97857366 DT.100857164 DT.456280 DT.100857159 DT.100857141 DT.121207167 DT.95261553 DT.95260956

DT.95217757 DT.100857156 DT.100032011 DT.100836521 DT.100857165 DT.121207200 DT.91688702 DT.91812521

DT.95294234 DT.121207149 DT.121207170 DT.121207195 DT.95261534 DT.95261550 DT.95261552 DT.95261554

24/784 AceView cDNA sequences (see all 784):

AW264134 AA558444 BU956546 CR605663 CR619496 BU178245 BQ436081 BQ017620

BU687945 AI368183 CA313100 CD365130 CD365562 BM015839 AA357565 AI261400

BM970044 BM915425 AW188941 CD742624 AA603737 AI301845 BG056867 AW167927

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for COPZ1 (see all 8) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	·	9c	·	9d
SP1:					-						-								-
SP2:					-		-				-								-
SP3:					-						-		-						-
SP4:					-		-				-		-						-
SP5:					-				-		-		-						-

ECgene alternative splicing isoforms for COPZ1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

COPZ1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGTCAGGAG

About this image
See COPZ1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COPZ1

SOURCE GeneReport for Unigene cluster: Hs.505652

SABiosciences Custom PCR Arrays for COPZ1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COPZ1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat COPZ1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COPZ1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COPZ1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPZ1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for COPZ1 gene from 9/33 species (see all 33) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Copz1^{1 , 5}	coatomer protein complex, subunit zeta 1^{1, 5}	93.22(n)¹ 100(a)¹		15 (58.74 cM)⁵ 56447¹ NM_019817.1¹ NP_062791.1¹ 103272918⁵
lizard (Anolis carolinensis)	Reptilia	COPZ1⁶	--	94(a)	1 ↔ 1	2(71191196-71199537)
African clawed frog (Xenopus laevis)	Amphibia	Xl.22784²	Xenopus laevis, Similar to coatomer protein complex, subunit zeta 1, clone IMAGE5569945, mRNA, partial cds less	80.52(n)		BC047988.1
zebrafish (Danio rerio)	Actinopterygii	copz1²	coatomer protein complex, subunit zeta 1	80.14(n)		57970 AB040044.2
fruit fly (Drosophila melanogaster)	Insecta	zetaCOP¹	CG3948-PA	64.04(n) 63.64(a)		39862 NM_140653.3 NP_648910.1
worm (Caenorhabditis elegans)	Secernentea	F59E10.3¹	Protein F59E10.3	58.97(n) 56.8(a)		174675 NM_063937.2 NP_496338.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RET3(YPL010W)⁴ RET3¹	Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER less⁴ Ret3p¹	51.56(n)¹ 43.88(a)¹		16(535018-535587)⁴ 856097^{1, 4} NP_015315.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G60970¹	coatomer subunit zeta-1	53.54(n) 46.67(a)		842388 NM_104777.3 NP_564767.1
rice (Oryza sativa)	Liliopsida	Os02g0317400¹	hypothetical protein	52.61(n) 45.78(a)		4329152 NM_001053207.1 NP_001046672.1

ENSEMBL Gene Tree for COPZ1 (if available)
TreeFam Gene Tree for COPZ1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for COPZ1 gene

COPZ2²

1 SIMAP similar gene for COPZ1 using alignment to 15 protein entries: COPZ1_HUMAN (see all proteins):

COPZ2

COPZ1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190645891^1,2		--	54716913(+)	`GCGGGA/CGGATC`	5	--	us2k¹		0	--	--	--	--
rs183192566^1,2		--	54716987(+)	`CAAAAA/TATCAG`	5	--	us2k¹		0	--	--	--	--
rs73113350^1,2	C,	--	54717230(+)	`TTTAGA/GATAAT`	5	--	us2k¹		0	--	--	--	--
rs12578224^1,2	C,H,	--	54717282(+)	`AGGAAA/GCCAAG`	5	--	us2k¹		5		NA CSA WA EA	362
rs202088368^1,2		--	54717404(+)	`TTCCT-/TCTC TCTCT`	5	--	us2k¹		0	--	--	--	--
rs11170867^1,2		--	54717410(+)	`TCTCTC/TTCTTT`	5	--	us2k¹ trp³		0	--	--	--	--
rs149206188^1,2	C,	--	54717450(+)	`TTTCT-/TTCCT TCCTTCCTTCCT`	5	--	us2k¹		0	--	--	--	--
rs191556836^1,2		--	54717472(+)	`TCCTTC/TCTTTC`	5	--	us2k¹		0	--	--	--	--
rs12813620^1,2		--	54717476(+)	`tccttT/Cctttc`	5	--	us2k¹ trp³		1		NA	2
rs114373285^1,2	F,	--	54717491(+)	`TTTTCT/ATTCTT`	5	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for COPZ1 (54694986 - 54745633 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for COPZ1
1 CNV: 49097

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

COPZ1 for disorders About GeneDecksing

3 diseases for COPZ1: About MalaCards

menkes disease cholesterol malaria

1 disease from the University of Copenhagen DISEASES database for COPZ1:

Menkes disease

Export disorders for COPZ1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for COPZ1 gene, integrated from 9 sources (see all 36):
(articles sorted by number of sources associating them with COPZ1)

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world of online information

Solution structure of human zeta-COP: direct evidences for structural similarity between COP I and clathrin-adaptor coats. (PubMed id 19167404)^{1, 2} Yu W....Xia B. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)^{1, 2} Zhang Q.-H.... Chen Z. (2000)
Identification and characterization of novel isoforms of COP I subunits. (PubMed id 11056392)^{1, 2} Futatsumori M.... Nakayama K. (2000)
Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)^{1, 2} Lai C.H....Lin W. (2000)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)¹ Oshikawa K....Nakayama K.I. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 22818	HGNC: 2243	AceView: COPZ1	Ensembl:ENSG00000111481	euGenes: HUgn22818
ECgene: COPZ1	H-InvDB: COPZ1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for COPZ1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for COPZ1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for COPZ1 gene:
Search GeneIP for patents involving COPZ1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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coatomer protein complex, subunit zeta 1

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coatomer protein complex, subunit zeta 1

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